TWAS hub - NFKBIB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0740	0.0300	0.00510	0.038	0.020	0.090	0.081	0.080	1.6e-05	1.3e-03	4.3e-11	4.5e-10	6.0e-10
2	GTEx	Spleen	0.2930	0.1110	0.00570	0.034	NA	0.165	NA	0.153	4.8e-02	NA	5.1e-05	NA	9.6e-05
3	TCGA	Brain Lower Grade Glioma	0.0591	0.0281	0.00043	0.041	0.036	0.035	NA	0.037	1.6e-05	5.1e-05	6.1e-05	NA	4.6e-05
4	TCGA	Prostate Adenocarcinoma	0.0471	0.0236	0.00130	0.038	0.028	0.042	NA	0.041	6.8e-05	5.4e-04	3.3e-05	NA	4.1e-05
5	TCGA	Testicular Germ Cell Tumors	0.1140	0.0590	0.00500	0.013	0.084	0.026	NA	0.034	1.1e-01	6.8e-04	4.2e-02	NA	2.3e-02
6	TCGA	Thyroid Carcinoma	0.0960	0.0430	0.00011	0.063	0.049	0.048	NA	0.054	9.3e-07	1.4e-05	1.7e-05	NA	5.2e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Medication: Ibuprofen (e.g. Nurofen)	5.7	7.3	12.2	-3.5	-1.5	-2.9	-2.7	2.2	-3.1
Medication: Ibuprofen	4.9	5.9	9.9	-3.1	-1.0	-2.5	-2.5	2.3	-2.7
Osteoporosis (self-reported)	4.4	5.5	10.6	-3.3	1.2	-2.0	-2.7	2.6	-1.7
Chronic bronchitis/emphysema (father)	3.7	4.3	10.6	-0.8	-3.3	-1.2	-1.4	3.1	-1.0
Medication for pain relief, constipation, heartburn	3.7	6.3	10.2	2.9	0.3	2.3	2.9	-2.4	3.2
Triglycerides	3.5	5.7	9.2	2.8	1.6	2.2	3.0	-2.4	2.0
Worrier / anxious feelings	3.1	5.8	12.3	-3.5	-0.3	-2.6	-2.8	1.3	-2.4
Illnesses of father: None of the above (group 1)	3.0	3.7	5.9	2.3	2.0	1.7	1.8	-2.4	1.1
Time employed in main current job	2.6	3.0	5.1	-1.7	-0.6	-2.2	-2.2	0.3	-2.2
Medication: Lansoprazole	2.6	3.0	6.4	-2.5	1.0	-2.0	-1.7	0.9	-1.6
Allergy or Eczema	2.4	6.4	8.4	2.7	1.9	2.9	2.9	-2.7	2.0
Average weekly fortified wine intake	2.4	2.8	5.5	1.6	-0.2	1.8	1.9	-2.3	1.4
Hayfever, allergic rhinitis or eczema	2.4	5.1	8.0	2.3	1.5	2.6	2.5	-2.8	1.5
Diabetes (father)	2.2	2.8	6.1	-0.9	-2.1	-1.7	-1.4	2.5	-0.8
Blood clot in the leg (DVT)	2.2	2.8	4.3	-1.8	-0.9	-1.5	-1.8	2.1	-1.6
Medication: Amlodipine	2.2	3.0	7.4	0.9	2.1	1.7	1.6	-2.7	0.7
Medication: Gliclazide	2.2	2.5	5.1	2.3	0.1	1.7	1.8	0.9	1.7
Ever taken oral contraceptive pill	2.2	2.5	4.4	1.1	-0.5	2.1	2.1	-1.6	1.5
Fed-up feelings	2.1	3.8	7.0	-2.0	0.6	-2.6	-2.3	1.6	-1.8
Wears glasses or contact lenses	2.1	2.4	6.5	1.3	1.0	0.8	1.9	-2.5	1.1
Deep venous thrombosis (DVT) (self-reported)	2.0	2.5	3.4	-1.7	-0.5	-1.6	-1.8	1.8	-1.8
Bipolar Disorder or Schizophrenia	1.9	4.7	11.2	-3.4	-2.0	-1.6	-2.3	0.5	-2.2
Breast Cancer	1.9	4.5	8.8	3.0	0.7	2.1	2.5	-2.2	1.4
Medication: Lisinopril	1.9	2.4	7.8	0.8	2.8	1.1	1.2	-1.5	1.0
Blood Platelet Count	1.8	21.0	52.7	4.0	2.8	3.7	4.7	-7.3	3.6
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	3.2	1.5	0.9	1.3	1.4	-1.8	1.2
Glaucoma (self-reported)	1.8	2.2	4.1	0.3	2.0	1.8	1.2	-0.2	2.0
Exposure to tobacco smoke outside home	1.8	2.4	4.6	-2.1	-2.0	-1.2	-1.3	1.1	-1.1
Depressed Affect (Nagel 2018)	1.7	3.5	11.9	-1.4	0.5	-1.5	-1.8	3.5	-1.2
Hip circumference	1.7	7.4	13.6	-2.8	0.1	-3.7	-3.0	2.0	-3.2
Qualifications: nursing, teaching	1.7	2.6	5.4	2.3	1.6	1.7	1.7	-0.5	1.4
Neuroticism (2016)	1.6	2.3	3.3	-1.8	0.4	-1.8	-1.8	1.3	-1.5
Number of children fathered	1.6	1.8	2.8	1.7	0.4	1.5	1.4	-1.2	1.4
Shortness of breath walking on level ground	1.6	1.9	3.6	-1.9	-0.6	-1.7	-1.2	0.3	-1.6
Eye problems/disorders: Glaucoma	1.6	1.9	4.3	0.8	1.4	1.8	1.1	0.3	2.1
Alzheimer’s Disease (in mother)	1.5	1.8	3.0	1.5	0.4	1.7	1.7	-1.1	1.1
Systolic Blood Pressure	1.5	7.5	13.5	2.4	3.2	2.7	2.3	-3.7	1.7
Lung cancer (father)	1.5	1.8	3.5	-1.3	-0.6	-1.9	-1.4	1.2	-1.2
Number of full brothers	1.5	1.8	3.7	-1.2	0.8	-1.6	-1.6	0.3	-1.9
Leg pain on walking	1.5	1.9	6.2	-1.5	-0.2	-0.8	-1.4	2.5	-0.5
High cholesterol (Self-reported)	1.5	2.7	4.0	-1.9	-1.4	-1.3	-2.0	1.7	-1.4
Bipolar Disorder (2018)	1.4	2.2	4.5	-2.1	-0.3	-1.6	-1.5	0.7	-1.9
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	4.0	-0.6	-1.0	-2.0	-1.7	0.6	-1.2
Alcohol usually taken with meals	1.4	2.2	4.0	1.6	-1.5	2.0	1.5	-0.4	1.5
Pain all over the body in last month	1.4	1.5	2.6	1.0	-1.3	0.8	1.6	1.0	1.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	3.2	1.5	0.5	1.6	1.8	-1.4	1.2
Tense / ‘highly strung’	1.4	2.3	3.6	1.6	1.9	1.8	1.5	-0.8	1.2
Mineral and other dietary supplements	1.4	1.9	9.1	0.2	1.2	-0.3	0.6	-3.0	-0.8
Supplements: Fish oil (including cod liver oil)	1.4	1.9	9.5	-0.2	-1.0	0.3	-0.6	3.1	0.5
Schizophrenia (2018)	1.3	2.6	6.5	-2.5	-2.2	-0.7	-1.6	0.2	-1.2
Hearing difficulty/problems: Yes	1.3	1.9	3.1	-1.4	-1.8	-1.2	-1.4	1.6	-0.9
Allergy	1.3	3.0	4.3	-1.8	-1.9	-2.1	-1.8	1.7	-1.0
Whole body fat mass	1.3	5.2	11.4	-2.1	-0.2	-3.4	-2.5	1.4	-2.7
Asthma (self-reported)	1.3	2.6	3.7	1.8	1.9	1.9	1.7	-1.2	0.5
Medication: Blood pressure	1.3	2.4	3.5	1.7	1.9	1.7	1.6	-0.6	1.5
Pain type(s) experienced in last month: Hip pain	1.3	1.7	2.5	-0.7	1.2	-1.6	-1.6	1.1	-1.4
Illnesses of father: High blood pressure	1.3	1.6	5.3	-2.3	-0.3	-1.0	-1.3	0.2	-1.3
Average weekly beer plus cider intake	1.3	1.9	3.3	-1.8	0.8	-1.4	-1.4	1.2	-1.4
Myopia	1.3	1.8	4.2	-2.1	0.7	-1.2	-1.5	0.1	-1.5
Townsend deprivation index at recruitment	1.2	1.7	3.6	-1.9	1.0	-1.4	-1.4	0.2	-1.2
Supplements: Glucosamine	1.2	1.6	3.0	-0.8	-1.7	-0.9	-1.7	1.5	-0.2
Trunk fat mass	1.2	5.2	11.3	-2.1	-0.3	-3.4	-2.5	1.3	-2.7
Waist circumference	1.2	4.5	8.0	-2.5	1.2	-2.8	-2.1	-0.0	-2.7
Had menopause	1.2	1.5	4.2	-0.4	-1.5	-1.0	-1.0	2.1	-0.3
Length of working week for main job	1.2	1.3	3.9	1.0	0.2	0.5	1.6	-2.0	0.4
Loud music exposure frequency	1.2	1.3	3.9	-0.7	-2.0	-1.4	-0.0	0.5	-1.0
Osteoarthritis (self-reported)	1.2	1.6	2.9	-1.0	-1.1	-1.5	-1.3	1.7	-0.8
Smoking status: Current	1.2	2.0	4.4	-1.7	0.2	-2.1	-0.9	-0.6	-1.8
Leg fat mass (left)	1.2	4.7	10.5	-1.8	0.3	-3.2	-2.3	0.9	-2.8
Blood White Count	1.1	7.9	15.1	2.6	1.6	2.7	3.1	-3.9	2.5
Medication: Atenolol	1.1	1.4	2.0	-1.4	-1.0	-1.2	-1.2	0.8	-1.4
Body fat percentage	1.1	4.5	9.9	-2.1	-0.1	-3.1	-2.3	0.4	-2.7
Leg fat mass (right)	1.1	4.2	9.3	-1.6	0.3	-3.0	-2.2	0.9	-2.7
Arm predicted mass (right)	1.1	5.4	10.9	-1.7	-1.1	-2.8	-2.3	3.3	-2.1
Comparative height size at age 10	1.1	6.0	17.9	-1.5	-0.9	-2.6	-2.4	4.2	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	3.7	1.6	0.5	1.9	1.6	-0.1	1.2
Arm fat mass (left)	1.1	4.6	11.0	-2.0	0.2	-3.3	-2.3	0.8	-2.6
Average weekly champagne plus white wine intake	1.1	1.6	4.1	2.0	-0.9	1.3	1.4	-0.5	0.8
Leg fat percentage (left)	1.1	4.0	8.8	-1.9	-0.1	-3.0	-2.1	0.3	-2.7
Coronary Artery Disease (CAD)	1.0	1.2	4.5	1.6	-2.1	0.0	0.0	0.0	0.0
Schizophrenia (2014)	1.0	2.3	4.7	-2.2	-2.2	-0.8	-1.3	-0.2	-1.4
Medication: Co-codamol	1.0	1.2	2.6	1.6	0.9	0.8	1.1	-1.1	0.7
Trunk fat percentage	1.0	3.8	8.9	-1.9	-0.3	-3.0	-2.2	0.4	-2.4
Current tobacco smoking	1.0	1.7	3.6	-1.6	0.4	-1.9	-0.8	-0.8	-1.6
Relative age voice broke	1.0	1.5	2.1	-1.4	-1.2	-1.3	-1.3	-0.2	-1.5
High blood pressure	1.0	2.7	6.6	1.1	2.6	1.5	1.4	-1.9	0.8
Body mass index (BMI)	1.0	4.4	10.1	-1.9	0.2	-3.2	-2.2	0.3	-2.8
Weight	1.0	5.1	10.6	-1.9	-0.0	-3.3	-2.4	2.0	-2.5
Noisy workplace	1.0	1.2	2.0	-1.3	-1.4	-1.0	-1.2	0.8	-0.5
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.8	1.0	0.4	1.9	1.6	-1.9	1.5
Depression (self-reported)	1.0	1.2	2.2	-1.1	0.8	-1.4	-1.5	0.6	-0.9
Arm fat mass (right)	1.0	4.3	10.5	-1.8	0.3	-3.2	-2.1	0.7	-2.6
Arm fat-free mass (right)	1.0	4.9	11.8	-1.4	-1.2	-2.6	-2.1	3.4	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.8	-0.9	-0.7	0.0	-1.2	2.0	-0.6
Medication: Blood pressure	1.0	1.7	5.8	0.4	2.4	-0.0	0.3	-2.0	-0.6
Hypertension (Self-reported)	1.0	2.7	7.1	1.3	2.7	1.6	1.3	-1.7	0.8
Arm fat percentage (left)	1.0	4.0	9.3	-1.9	0.3	-3.0	-2.1	-0.2	-2.6
Loneliness, isolation	1.0	1.4	4.5	-0.7	2.1	-1.1	-0.7	-0.7	-1.1
Diabetes diagnosed by doctor	1.0	1.7	3.3	1.6	-0.2	1.8	1.7	-0.2	1.1
Eye problems/disorders: Cataract	1.0	1.2	2.8	-0.5	1.7	-0.6	-0.7	-1.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	1.6	-1.2	1.0	-1.3	-1.3	0.5	-1.0
Back pain experienced in last month	1.0	1.4	4.2	-0.9	2.0	-0.7	-0.7	1.4	-0.6
Commuting to job workplace: Cycle	1.0	1.2	1.9	-1.4	-0.7	-0.9	-1.2	1.3	-0.8
Ovarian Cancer	0.9	1.2	3.4	0.4	1.3	0.9	0.9	-1.8	0.4
HDL Cholesterol	0.9	1.5	3.7	-1.9	-0.1	-1.1	-1.3	-0.3	-1.6
Neuroticism	0.9	2.3	3.3	-1.8	1.2	-1.5	-1.5	1.2	-1.6
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	1.5	-1.2	-0.9	-1.0	-0.8	0.4	-1.2
Qualifications: CSEs or equivalent	0.9	1.2	2.6	-0.2	1.6	0.8	1.1	-1.3	1.0
Arm fat percentage (right)	0.9	3.4	7.6	-1.7	0.6	-2.8	-1.8	-0.6	-2.4
Asthma	0.9	1.8	4.0	1.3	2.0	1.4	1.3	-1.1	0.1
Leg fat percentage (right)	0.9	3.4	7.4	-1.6	0.0	-2.7	-2.0	0.4	-2.5
Medication: Allopurinol	0.9	1.2	2.4	1.6	-0.3	1.3	1.5	-0.1	0.8
Average weekly red wine intake	0.9	1.3	4.0	-1.2	-0.8	-0.4	-1.1	2.0	-0.8
Friendships satisfaction	0.9	1.2	2.4	-1.6	0.3	-0.9	-1.1	-0.1	-1.5
Commuting to job workplace: Walk	0.9	1.0	4.6	-0.5	-2.1	-0.6	-0.6	0.4	-0.5
Miserableness	0.9	1.6	3.3	-1.5	1.8	-1.2	-1.1	0.3	-1.1
Risk taking	0.9	1.3	2.5	-1.1	-0.4	-1.6	-0.7	-1.1	-1.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.6	-1.1	1.2	-0.7	-1.1	1.6	-0.2
Vitamin and mineral supplements	0.8	1.1	1.9	-0.4	0.9	-1.2	-0.6	-1.3	-1.4
Diabetes (mother)	0.8	1.0	4.5	0.9	0.2	0.4	0.6	2.1	0.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.8	1.3	-0.8	0.6	1.3	-0.1	0.9
Father’s age at death	0.8	1.1	3.2	-0.3	0.1	-0.5	-1.4	1.8	-1.0
Health satisfaction	0.8	1.1	2.4	-1.6	0.7	-1.2	-0.9	0.4	-1.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.6	0.1	-1.9	-0.0	-0.4	1.3	-0.5
Mean time to correctly identify matches	0.8	1.6	2.3	1.4	-0.2	1.4	1.0	1.5	1.5
Pulse rate, automated reading	0.8	2.5	7.8	-0.5	2.0	-0.1	1.6	-2.8	-0.3
Knee pain experienced in last month	0.8	1.3	2.5	-1.0	0.2	-1.0	-1.4	1.6	-1.1
Whole body water mass	0.8	4.3	10.3	-1.5	-0.3	-2.5	-2.1	3.2	-1.7
Commuting to job workplace: Public transport	0.8	0.9	4.1	-0.2	-2.0	-0.4	-0.7	0.7	-0.5
Basal metabolic rate	0.8	4.4	8.6	-1.6	-0.2	-2.7	-2.1	2.9	-1.9
Age started oral contraceptive pill	0.8	1.0	2.0	1.4	0.3	0.9	1.2	-0.3	1.2
Unable to work because of sickness or disability	0.8	1.1	4.1	-1.1	0.6	0.0	-0.7	2.0	-0.5
Cholesterol lowering medication	0.8	1.2	2.6	-0.8	-1.4	-0.5	-1.1	1.6	-0.6
Arm predicted mass (left)	0.8	3.8	9.7	-1.2	-0.7	-2.4	-1.8	3.1	-1.5
Irritable Bowel Disease (IBD)	0.7	1.7	2.9	1.7	1.5	0.9	0.9	-1.4	1.2
Rheumatoid Arthritis	0.7	0.9	3.2	0.5	1.3	-0.3	-0.3	-1.8	-0.2
BMI	0.7	4.0	8.8	-1.7	1.0	-2.6	-2.1	0.1	-3.0
Waist Hip Ratio (WHR)	0.7	3.1	9.5	-0.4	3.1	1.3	1.2	-2.2	1.0
Relative age of first facial hair	0.7	1.5	2.9	-1.6	-0.2	-1.7	-1.5	0.3	-1.1
Supplements: Zinc	0.7	0.7	1.7	-0.7	0.1	-0.7	-1.1	1.3	-0.6
Leg fat-free mass (left)	0.7	3.8	6.5	-1.5	0.2	-2.5	-2.1	2.4	-2.0
Maternal smoking around birth	0.7	1.1	1.6	-1.1	-0.8	-1.3	-1.2	0.8	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.6	-0.7	1.2	-0.6	-1.1	1.1	-0.7
Leg predicted mass (left)	0.7	3.9	6.2	-1.5	0.1	-2.5	-2.1	2.5	-2.0
Fluid intelligence score	0.7	1.5	2.9	0.9	1.2	1.5	1.0	0.7	1.7
Trunk fat-free mass	0.7	3.7	11.7	-1.1	-0.3	-2.2	-1.7	3.4	-1.3
Suffer from ‘nerves’	0.7	1.1	2.0	-0.8	1.2	-1.0	-1.4	0.3	-1.2
Whole body fat-free mass	0.7	4.2	9.8	-1.4	-0.3	-2.5	-2.0	3.1	-1.7
Leg fat-free mass (right)	0.7	3.9	6.4	-1.6	0.1	-2.5	-2.1	2.4	-2.1
Mood swings	0.7	1.2	3.6	-1.2	1.1	-0.3	-1.0	1.9	-0.4
Medication: Aspirin	0.7	0.9	1.8	-0.9	-0.0	-0.7	-1.3	0.9	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.7	-1.1	0.6	-1.9	-1.3	1.0	-0.6
Leg predicted mass (right)	0.7	3.8	6.2	-1.5	0.1	-2.5	-2.1	2.3	-2.0
Medication: Bendroflumethiazide	0.7	1.1	1.9	-0.8	1.4	-1.0	-1.2	0.2	-1.1
Ulcerative Colitis (UC)	0.6	1.1	2.5	1.6	1.1	1.1	0.7	-0.6	1.1
Crohns Disease (2012)	0.6	0.9	2.6	1.3	1.0	0.1	0.4	-1.6	0.4
Smoking Status	0.6	1.4	2.8	-1.1	0.2	-1.7	-1.1	0.8	-1.5
Severe depression (siblings)	0.6	0.7	1.4	-1.1	0.3	-0.8	-1.2	0.6	-0.8
Taking other prescription medications	0.6	0.9	2.7	1.1	1.6	0.9	0.4	-0.4	0.4
Age when periods started (menarche)	0.6	1.5	2.5	0.8	-0.0	1.1	1.6	-1.6	1.4
Hearing difficulty/problems with background noise	0.6	0.9	1.9	-1.1	-1.4	-0.7	-0.5	1.2	-0.3
Illnesses of siblings	0.6	0.8	1.6	1.2	-1.1	0.2	0.8	-0.9	0.5
Falls in the last year	0.6	0.9	1.9	0.2	-1.4	1.0	1.1	0.4	0.9
Medication: Cholesterol lowering	0.6	0.9	1.7	1.1	1.0	1.3	1.0	0.1	0.7
Trunk predicted mass	0.6	3.6	11.8	-1.0	-0.4	-2.1	-1.7	3.4	-1.2
Exposure to tobacco smoke at home	0.6	0.7	1.9	-1.0	-0.3	-0.4	-0.5	1.4	-0.9
Birth weight of first child	0.6	1.1	6.0	0.6	0.2	0.5	-0.2	2.5	0.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	4.1	-0.5	-2.0	-0.6	-0.5	0.8	-0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.8	-0.6	-0.8	-0.6	-0.1	-1.2	-1.3
Illnesses of siblings: Diabetes	0.6	0.8	2.0	1.1	-0.2	0.6	0.4	1.4	0.9
Ever had bowel cancer screening	0.6	0.7	2.5	-0.4	1.6	-0.1	-1.0	0.4	-0.4
Financial situation satisfaction	0.6	0.7	1.8	0.4	-1.4	0.5	0.6	-1.3	0.2
Arm fat-free mass (left)	0.6	3.0	7.5	-1.1	-0.4	-2.2	-1.7	2.7	-1.4
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.1	-0.8	-1.8	-1.6	-1.2	1.2	-0.9
Heart disease (siblings)	0.6	0.8	1.9	0.3	-0.7	1.2	1.4	-0.3	0.8
Depression (Nagel 2018)	0.5	0.8	4.4	-0.3	0.0	-0.0	-0.5	2.1	0.2
Neuroticism (Nagel 2018)	0.5	1.1	2.8	-1.1	0.1	-0.6	-1.0	1.7	-1.1
Lupus	0.5	0.7	2.7	0.7	-1.0	0.3	0.1	1.7	0.3
Respiratory disease	0.5	1.0	2.2	1.5	0.7	1.2	1.0	-1.1	-0.1
Lung FVC	0.5	2.6	4.4	-2.0	-0.0	-2.0	-2.1	0.6	-1.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.1	0.4	0.7	1.1	0.7	0.7	0.9
Ever had hysterectomy (womb removed)	0.5	0.6	2.7	-0.0	-1.6	0.0	0.3	-0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.0	1.3	-1.4	1.1	1.0	-0.0	1.1
Multivitamins +/- minerals	0.5	0.6	2.8	-0.4	-1.7	-0.2	-0.3	0.7	0.3
Stomach or abdominal pain in last month	0.5	0.7	1.9	0.3	1.4	0.4	0.3	-1.3	-0.1
Past tobacco smoking	0.5	0.9	1.9	0.6	-0.0	1.1	1.2	-0.5	1.4
Hair/balding pattern: Pattern 2	0.5	0.6	1.4	-0.2	-0.7	-0.6	-1.1	-0.1	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.9	1.2	-0.9	1.4	1.0	0.5	1.1
Medication: Ramipril	0.5	0.7	2.3	-0.2	1.5	0.5	0.6	-1.1	0.3
Neuroticism score	0.5	1.1	2.8	-1.1	1.7	-1.0	-0.8	0.1	-1.0
Impedance of arm (right)	0.5	2.4	3.6	1.2	0.9	1.8	1.5	-1.9	1.6
Number of live births	0.5	0.7	1.8	-1.1	0.5	-0.8	-0.6	-0.7	-1.3
Hair/balding pattern: Pattern 4	0.5	1.2	4.5	0.2	-2.1	0.5	0.3	1.5	0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.7	-0.3	1.6	0.8	0.5	-0.9	0.3
Gout (self-reported)	0.5	0.7	1.8	0.8	0.4	0.9	1.4	-0.7	0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	-0.7	0.3	-1.0	-0.2	-0.8	-1.1
High blood pressure (siblings)	0.5	0.8	3.0	-1.0	1.7	0.5	-0.4	0.5	-0.2
Eye problems/disorders: None of the above	0.5	0.6	1.5	1.2	0.5	0.3	0.7	-1.0	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	0.3	-0.3	1.1	0.7	-1.1	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.5	0.5	-0.8	0.3	0.4	-1.6	-0.1
Medication: Aspirin	0.5	0.7	1.2	-0.7	-0.4	-0.6	-1.1	0.8	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	2.1	-0.6	1.4	-0.1	-0.4	-0.7	-0.4
Long-standing illness, disability or infirmity	0.5	0.7	3.6	-0.0	0.7	0.1	-0.4	1.9	-0.3
Number of self-reported non-cancer illnesses	0.5	0.9	2.8	0.7	1.7	1.0	0.8	-0.4	0.5
Hearing aid user	0.5	0.6	0.8	0.6	0.8	0.9	0.9	-0.8	0.5
Alcohol drinker status: Never	0.5	0.6	1.3	-0.1	0.3	-0.9	-0.3	-1.2	-1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.9	-0.8	-1.4	-0.1	-0.4	-0.1	-0.4
Alzheimer’s Disease (including proxy)	0.4	0.5	1.1	1.0	-0.2	1.0	0.9	-0.5	0.4
Crohns Disease (2017)	0.4	0.8	1.4	1.1	0.6	0.6	0.8	-1.1	1.2
Reaction Time	0.4	0.7	1.3	1.1	0.1	0.9	0.6	0.9	0.9
Fasting Glucose	0.4	0.4	1.0	0.8	0.2	0.7	0.3	1.0	0.5
LDL Cholesterol	0.4	0.7	1.6	-1.3	0.2	-1.0	-0.5	0.0	-1.0
Primary Biliary Cirrhosis	0.4	0.5	2.8	0.3	1.7	0.3	-0.1	-0.4	0.1
Ulcerative Colitis	0.4	0.6	1.4	1.2	0.9	0.8	0.5	-0.5	0.8
Blood Eosinophil Count	0.4	3.2	13.1	1.6	1.0	-0.2	1.6	-3.6	-0.2
Blood Red Count	0.4	4.0	6.7	2.6	1.3	1.8	2.0	-1.9	2.2
Height	0.4	7.9	39.3	-0.1	-2.5	-0.8	-1.0	6.3	0.6
Lung FEV1/FVC ratio	0.4	2.2	5.4	0.7	2.3	0.5	1.6	-1.8	1.1
Sensitivity / hurt feelings	0.4	0.8	1.6	-1.2	1.1	-0.8	-1.0	-0.1	-0.4
Systolic blood pressure, automated reading	0.4	1.1	4.3	0.5	2.1	0.6	0.1	-1.2	0.6
Impedance of leg (right)	0.4	2.1	3.8	1.1	-0.8	1.9	1.6	-0.8	1.9
Serious illness, injury or assault to yourself	0.4	0.5	1.3	-0.8	1.2	0.3	0.1	-0.8	0.0
Had other major operations	0.4	0.5	2.0	-0.2	-1.4	-0.9	-0.4	0.3	-0.3
Forced vital capacity (FVC)	0.4	1.6	3.1	-1.3	-0.0	-1.5	-1.4	1.8	-0.7
Pulse rate	0.4	0.6	1.3	-0.8	0.8	-0.3	0.6	-1.1	-0.9
Illnesses of mother	0.4	0.5	2.2	0.2	0.3	-0.6	0.1	-1.5	-0.2
Breastfed as a baby	0.4	0.6	1.5	0.7	-0.4	0.8	0.6	-0.3	1.2
Worry too long after embarrassment	0.4	0.7	1.5	0.5	1.2	0.5	0.9	-0.1	1.1
Age at first live birth	0.4	0.8	1.5	1.1	1.2	0.1	0.5	-1.2	0.1
Heart disease (mother)	0.4	0.5	2.2	-0.1	-0.2	0.7	0.3	1.5	0.7
Overall health rating	0.4	0.9	2.2	-1.5	1.1	-0.8	-0.7	0.3	-1.0
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.1	-0.4	0.9	-0.4	-0.6	-0.2	-1.0
Illnesses of father: Heart disease	0.4	0.5	1.1	-0.7	-0.6	-0.9	-0.4	1.0	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.3	0.8	0.6	0.6	-0.7	0.6
Medication: Atorvastatin	0.4	0.4	1.5	0.3	-1.2	0.8	0.4	0.4	0.4
Ever smoked	0.4	0.8	1.4	-0.9	0.6	-1.0	-1.1	-0.2	-1.2
Pack years of smoking	0.4	0.6	1.5	-1.2	-0.3	-0.6	-0.8	0.4	-0.8
Worry (Nagel 2018)	0.3	0.6	1.6	-1.0	0.6	-0.4	-0.7	-0.2	-1.2
Prostate Cancer	0.3	0.4	1.1	-0.5	0.3	-0.1	-1.0	1.1	0.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	0.7	0.2	1.2	0.8	0.5	0.6
Hair Pigment	0.3	8.3	13.6	-3.7	-1.0	-3.4	-3.6	1.5	-3.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	0.9	-1.0	0.2	0.3	0.3	0.5
Angina	0.3	0.4	1.1	-1.0	-0.0	-0.4	-0.8	-0.1	-0.7
Pack years adult smoking proportion	0.3	0.5	1.2	-1.1	-0.3	-0.6	-0.6	-0.0	-0.9
Sitting height	0.3	1.8	3.6	1.9	-0.7	0.8	1.4	1.6	1.3
High blood pressure (mother)	0.3	0.4	1.4	0.1	1.2	0.7	-0.1	0.8	0.3
Impedance of leg (left)	0.3	1.5	2.5	0.7	-1.2	1.6	1.3	-0.8	1.5
Number of incorrect matches in round	0.3	0.5	2.5	0.3	0.5	-0.2	-0.6	1.6	-0.0
Nervous feelings	0.3	0.5	1.8	0.2	0.8	0.4	0.7	-1.4	-0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.5	-0.6	0.6	-0.7	-0.6	0.5	-0.4
Alcohol intake versus 10 years previously	0.3	0.4	0.7	-0.5	0.4	-0.8	-0.8	-0.2	-0.7
Happiness	0.3	0.4	2.0	0.0	-0.3	-0.5	0.1	-1.4	-0.2
Standing height	0.3	3.1	16.8	-0.3	-0.7	-0.7	-0.8	4.1	0.3
Pulse wave reflection index	0.3	0.3	1.0	-0.1	-0.2	0.6	0.0	0.8	1.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	-0.2	0.4	0.5	0.9	0.9	0.5
Wheeze or whistling in the chest in last year	0.3	0.6	1.3	1.0	1.1	0.3	0.3	-1.0	-0.1
Migraine (self-reported)	0.3	0.4	1.2	-0.1	1.1	-0.5	-0.5	0.1	-0.9
Medication: Seretide 50 evohaler	0.3	0.3	1.0	-0.5	1.0	0.3	0.3	-0.7	0.1
Supplements: Vitamin C	0.3	0.4	1.0	0.7	-0.5	1.0	0.5	0.0	0.5
Smoking status: Previous	0.3	0.5	1.2	-0.2	-0.6	-0.4	-1.0	1.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.7	-0.5	1.1	-0.6	-0.5	1.3	-0.5
Irritability	0.3	0.5	1.1	0.6	0.7	0.7	1.0	-0.6	0.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	0.0	-0.8	0.1	0.8	-1.0	0.3
Diastolic blood pressure, automated reading	0.3	0.9	3.1	-0.3	1.2	0.6	0.3	-1.8	0.5
Ever depressed for a whole week	0.3	0.3	1.1	0.2	-0.6	0.1	-0.1	1.0	0.7
Supplements: Calcium	0.3	0.3	0.9	0.9	-0.1	0.4	0.3	0.5	0.6
Alcohol drinker status: Previous	0.3	0.3	1.2	-0.3	-1.1	0.0	-0.5	0.5	0.0
Impedance of whole body	0.3	1.7	3.2	0.9	-0.5	1.8	1.4	-1.2	1.6
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.2	0.4	1.1	0.2	-0.0	1.5	0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.5	-0.2	-0.4	-0.5	0.3	-0.5
Major Depression (MDD)	0.2	0.3	0.7	0.3	0.0	0.8	0.7	0.1	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.7	0.2	0.7	0.1	0.3	1.3	0.9
Age at First Birth	0.2	0.3	1.2	0.3	-1.1	0.3	0.1	-0.5	0.3
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	0.4	0.6	0.3	0.4	-0.6	0.4
Mean Putamen Volume	0.2	0.2	0.6	0.4	0.8	-0.5	-0.3	-0.4	-0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.9	0.4	-0.9	0.0	0.0	0.0	0.0
Heel T-Score	0.2	1.6	2.8	1.5	-0.9	1.7	1.5	-0.9	0.9
Cardiovascular Disease	0.2	0.6	1.0	-1.0	1.0	-0.2	-0.9	0.2	-1.0
Hypothyroidism (self reported)	0.2	0.6	1.0	-1.0	-0.6	-0.8	-0.4	0.7	-0.8
Medication for hormone replacement therapy	0.2	0.2	0.7	-0.3	-0.2	0.1	0.5	-0.8	0.3
Medication: Metformin	0.2	0.3	0.6	0.5	0.4	0.5	0.8	0.7	0.2
Hand grip strength (right)	0.2	0.4	1.7	0.5	-1.3	0.3	0.2	0.6	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.2	-0.2	0.4	0.4	0.0	1.1	0.3
Mouth/teeth dental problems	0.2	0.2	1.0	-0.0	-1.0	-0.3	-0.6	0.1	-0.1
Diabetes (self-reported)	0.2	0.4	0.8	0.9	-0.1	0.8	0.9	0.0	0.3
Medication: Simvastatin	0.2	0.3	1.0	-0.1	0.5	-0.0	-0.5	1.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	0.0	1.0	-0.0	0.1	0.9	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.6	-0.9	0.5	-1.3	-0.8	0.8	-0.3
Prospective memory result	0.2	0.3	0.7	0.8	0.2	0.1	-0.2	0.8	0.4
Impedance of arm (left)	0.2	0.8	1.7	0.6	-0.2	1.3	0.8	-1.0	1.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	0.4	0.5	0.3	0.7	-0.3	0.1
Forced vital capacity (FVC), Best measure	0.2	0.7	1.1	-1.0	0.3	-1.1	-0.9	1.0	-0.4
Comparative body size at age 10	0.2	0.5	1.4	0.3	-1.2	-0.6	-0.3	1.0	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.9	0.8	0.2	0.0	0.7	0.2
Emphysema/chronic bronchitis	0.2	0.2	0.7	-0.3	-0.7	-0.0	-0.3	0.8	0.0
Neck or shoulder pain in last month	0.2	0.2	1.1	-0.4	1.0	0.2	-0.1	0.1	-0.1
Angina (self-reported)	0.2	0.3	0.8	-0.9	-0.3	-0.3	-0.6	0.2	-0.5
Medication: Omeprazole	0.2	0.2	0.9	-0.4	1.0	-0.3	0.1	0.0	0.0
Number of full sisters	0.2	0.3	1.4	-1.2	0.4	-0.2	-0.3	-0.0	-0.0
Had major operations	0.2	0.2	0.5	-0.7	0.3	0.5	-0.4	-0.1	-0.3
Family relationship satisfaction	0.2	0.2	0.6	-0.4	0.2	-0.6	0.4	-0.8	-0.2
Mother’s age at death	0.2	0.3	1.1	-0.1	-0.5	0.5	0.1	1.0	0.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.7	-0.7	0.4	-0.3	0.5	-0.0
Number of operations (self-reported)	0.2	0.3	0.7	-0.3	-0.4	0.8	0.2	0.7	0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.7	-0.5	-0.6	-0.5	-0.1	0.8	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	-0.4	1.0	-0.4	0.0	-0.1	-0.2
HbA1C	0.1	0.1	0.3	0.6	0.5	-0.1	0.1	-0.0	0.2
Chronotype (morning person)	0.1	0.3	0.7	0.6	-0.8	-0.4	0.1	-0.8	-0.2
Tanning	0.1	1.2	3.9	2.0	0.4	1.0	1.2	-0.0	0.8
Hand grip strength (left)	0.1	0.3	0.9	0.4	-0.7	0.6	-0.1	1.0	0.1
Number of treatments/medications taken	0.1	0.2	1.0	-0.0	1.0	0.3	0.4	0.2	0.2
Average weekly spirits intake	0.1	0.1	0.3	0.3	0.3	-0.6	0.3	-0.2	-0.4
Medication: Levothyroxine sodium	0.1	0.1	0.3	0.6	0.5	0.0	0.3	-0.1	0.0
Qualifications: None of the above	0.1	0.1	0.4	-0.3	0.4	-0.6	-0.4	-0.0	-0.2
Financial difficulties in last 2 years	0.1	0.2	0.3	-0.5	0.1	-0.4	-0.4	0.5	-0.1
Heart attack	0.1	0.1	0.2	0.5	0.1	0.0	0.1	0.4	0.3
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.5	0.4	-0.2	0.1	0.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.1	0.0	0.4	0.2	-0.2	0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	-0.6	0.8	-0.5	-0.4	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	-1.0	0.8	-0.7	-0.6	0.1	-0.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.3	-0.0	0.4	0.2	-0.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.2	-0.6	-0.5	-0.0	-0.1	0.2
Peak expiratory flow (PEF)	0.1	0.3	1.3	-0.4	1.1	0.0	0.0	-0.2	0.5
Medication: Paracetamol	0.1	0.1	0.4	-0.1	0.4	-0.2	0.0	0.2	-0.6
Headache pain in last month	0.1	0.2	1.1	-0.5	1.1	0.1	-0.3	0.1	-0.1
Pulse wave peak to peak time	0.1	0.1	0.1	0.3	0.2	-0.4	-0.3	0.4	-0.1
Alcohol intake frequency.	0.1	0.2	0.7	0.8	0.1	-0.2	0.5	-0.7	0.0
Chest pain or discomfort	0.1	0.1	0.3	-0.3	-0.2	0.0	-0.1	0.6	0.4
Age at last live birth	0.1	0.2	0.3	0.6	0.5	0.5	0.2	0.2	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.6	0.3	0.2	0.0	0.1	-0.8	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.5	0.3	0.1	-0.0	-0.4	-0.3
Medication for cholesterol	0.1	0.2	0.8	0.1	-0.9	-0.2	-0.0	0.5	-0.1
Breast cancer (self-reported)	0.1	0.1	0.5	-0.1	0.2	0.1	0.2	-0.1	0.7
Guilty feelings	0.1	0.1	0.3	-0.6	0.3	0.2	0.3	-0.4	0.3
Medication: Paracetamol	0.1	0.1	0.2	0.4	0.5	0.4	0.2	0.4	-0.1
Pain experienced in last month	0.1	0.2	0.7	-0.1	-0.9	-0.5	-0.2	-0.5	-0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.4	0.1	0.4	0.3	0.0	0.7	0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.3	0.1	-0.2	-0.1	0.6	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	-0.4	-0.3	-0.2	-0.2	0.2	-0.3
Birth weight	0.0	0.1	0.4	-0.4	-0.3	-0.0	-0.0	0.6	0.2
Qualifications: College or University degree	0.0	0.1	0.4	0.4	-0.6	-0.1	0.0	0.0	-0.5

Hub : Genes

NFKBIB

Models

Trait associations