TWAS hub - NFS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Frontal Cortex BA9	0.2654	0.0995	0.0069	0.199	NA	0.129	NA	0.169	5.6e-06	NA	0.00028	NA	3.1e-05
2	GTEx	Muscle Skeletal	0.0297	0.0166	0.0027	0.019	NA	0.024	NA	0.027	5.0e-03	NA	0.00190	NA	1.0e-03
3	TCGA	Testicular Germ Cell Tumors	0.1090	0.0700	0.0043	0.000	0.037	0.010	NA	0.012	3.1e-01	0.018	0.13000	NA	1.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Sitting height	49.9	353.9	610.1	12.2	24.7	17.4
Standing height	37.9	375.5	658.2	13.3	25.7	17.1
Height	37.0	712.6	1260.2	16.8	35.5	24.4
Trunk predicted mass	36.7	209.6	372.5	8.9	19.3	13.3
Trunk fat-free mass	36.3	208.6	372.5	8.9	19.3	13.2
Whole body fat-free mass	33.2	189.6	342.2	8.1	18.5	12.7
Whole body water mass	32.9	187.9	338.6	8.0	18.4	12.7
Arm fat-free mass (right)	30.4	155.8	275.6	7.4	16.6	11.7
Arm predicted mass (right)	30.3	154.8	274.2	7.4	16.6	11.6
Arm predicted mass (left)	29.2	148.4	265.7	6.9	16.3	11.5
Basal metabolic rate	28.8	159.2	289.0	6.8	17.0	11.9
Arm fat-free mass (left)	28.8	145.9	260.2	7.1	16.1	11.3
Leg predicted mass (right)	28.5	152.2	282.2	6.5	16.8	11.5
Leg fat-free mass (right)	28.3	151.4	282.2	6.5	16.8	11.4
Leg fat-free mass (left)	26.8	142.2	262.4	6.0	16.2	11.3
Leg predicted mass (left)	26.7	141.7	262.4	6.1	16.2	11.2
Comparative height size at age 10	25.3	139.5	262.4	5.9	16.2	11.0
Hand grip strength (right)	18.0	48.9	86.9	5.0	9.3	5.9
Forced expiratory volume in 1-second (FEV1), predicted	14.1	29.4	52.3	3.7	7.2	4.7
Weight	13.9	68.2	125.8	2.9	11.2	8.4
Lung FVC	13.1	66.5	114.5	-3.9	-10.7	-8.3
Hand grip strength (left)	11.4	30.0	52.6	4.4	7.2	4.2
Knee pain experienced in last month	10.7	16.6	31.9	-3.0	-5.7	-3.0
Peak expiratory flow (PEF)	9.4	21.8	39.6	2.3	6.3	4.5
Tanning	8.2	100.6	210.2	6.6	14.5	6.9
Myopia	7.9	11.5	15.8	2.6	4.0	3.5
Hip circumference	7.4	31.7	59.8	1.1	7.7	5.8
Impedance of leg (right)	6.9	33.3	66.6	-2.7	-8.2	-5.1
Impedance of leg (left)	6.7	32.7	64.9	-2.5	-8.1	-5.2
Intelligence (Savage-Jansen 2018)	6.5	19.9	34.1	1.2	4.9	5.8
Commuting to job workplace: Walk	4.9	5.3	7.7	2.4	2.8	1.6
Qualifications: College or University degree	4.7	14.8	21.2	2.9	4.6	3.9
Relative age voice broke	4.6	7.0	10.4	1.1	-3.0	-3.2
Fluid intelligence score	4.6	9.6	15.7	-0.5	3.6	4.0
Length of working week for main job	4.5	4.9	7.3	1.0	2.6	2.7
Leg fat percentage (right)	4.5	16.3	24.9	-4.5	-5.0	-2.0
Alcohol usually taken with meals	4.4	7.1	10.6	1.6	2.8	3.3
Mean time to correctly identify matches	4.4	8.4	10.9	-2.4	-3.3	-2.9
Qualifications: CSEs or equivalent	4.3	5.6	8.0	-1.1	-2.8	-2.8
Reaction Time	4.2	7.9	9.8	-3.0	-3.1	-2.2
Qualifications: None of the above	4.1	8.8	13.8	-1.8	-3.7	-3.0
Hair Pigment	4.0	115.3	233.0	-5.4	-15.3	-9.1
Leg fat percentage (left)	4.0	14.4	21.4	-4.3	-4.6	-1.8
Impedance of whole body	4.0	20.5	39.9	-2.1	-6.3	-4.2
HDL Cholesterol	3.9	6.6	10.0	0.5	-3.1	-3.2
LDL Cholesterol	3.8	6.1	10.0	-0.0	-2.9	-3.2
Diverticular disease/diverticulitis (self-reported)	3.8	4.6	5.3	-1.9	-2.3	-2.2
Diabetes (self-reported)	3.8	5.8	9.6	0.1	2.8	3.1
Pulse rate	3.8	6.4	8.0	-2.2	-2.8	-2.5
Forced vital capacity (FVC), Best measure	3.6	13.1	20.3	3.4	4.5	2.8
Forced expiratory volume in 1-second (FEV1)	3.5	11.9	18.6	2.5	4.3	3.3
Forced expiratory volume in 1-second (FEV1), Best measure	3.5	11.2	16.2	3.0	4.0	2.9
Verbal and Numeric Reasoning (VNR)	3.4	8.1	13.2	0.5	3.3	3.6
Trunk fat mass	3.4	14.8	25.6	-0.1	5.1	4.3
Forced vital capacity (FVC)	3.1	12.1	20.2	2.7	4.5	2.9
Tinnitus: Yes, now most or all of the time	3.1	3.6	5.8	0.3	2.2	2.4
Age when periods started (menarche)	3.0	7.2	21.5	4.6	0.5	0.0
Number of full sisters	2.9	3.5	7.1	-2.7	-1.7	-0.8
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	4.0	1.6	2.0	1.7
Average weekly red wine intake	2.8	4.2	5.6	2.4	1.9	1.8
Osteoarthritis (self-reported)	2.8	3.7	5.3	-2.1	-2.3	-1.2
Waist circumference	2.7	9.8	14.9	-0.6	3.9	3.8
Wears glasses or contact lenses	2.7	3.1	4.0	2.0	1.7	1.6
Alzheimer’s Disease (in father)	2.6	2.8	4.0	-1.5	-2.0	-1.4
Alzheimer’s Disease (including proxy)	2.6	3.8	6.2	-0.6	-2.5	-2.2
Medication: Lansoprazole	2.6	3.0	4.8	-0.3	-2.2	-2.0
Relative age of first facial hair	2.5	5.1	8.5	0.5	-2.6	-2.9
Number of incorrect matches in round	2.5	4.1	6.7	-0.6	-2.6	-2.3
Qualifications: A levels/AS levels or equivalent	2.5	5.6	9.3	1.5	3.1	2.3
Chest pain or discomfort	2.5	3.7	6.9	-0.4	2.0	2.6
Age started oral contraceptive pill	2.5	3.1	8.9	3.0	0.5	0.3
Ulcerative Colitis	2.4	3.5	7.5	0.2	2.7	1.7
Sensitivity / hurt feelings	2.4	4.1	6.1	0.3	-2.5	-2.5
Medication: Metformin	2.4	3.4	5.0	0.6	2.2	2.2
Impedance of arm (right)	2.4	11.3	20.1	-1.8	-4.5	-3.2
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	7.7	0.7	2.8	1.8
Whole body fat mass	2.4	10.2	16.4	-0.4	4.1	3.7
Diabetes diagnosed by doctor	2.4	3.9	6.4	0.2	2.3	2.5
Average weekly beer plus cider intake	2.4	3.5	4.8	-1.1	-2.2	-2.1
Mouth/teeth dental problems: Bleeding gums	2.3	3.0	4.4	-2.0	-2.1	-0.7
Medication: Ventolin 100micrograms inhaler	2.3	2.9	5.3	-0.3	2.3	1.8
Number of operations (self-reported)	2.3	3.4	5.1	-1.6	-2.3	-1.6
Lung FEV1/FVC ratio	2.2	11.0	15.4	2.4	3.9	3.4
Medication: Co-codamol	2.2	2.5	6.1	-2.5	-1.2	-0.3
Diabetes (father)	2.2	2.7	4.3	-0.7	2.1	1.8
Past tobacco smoking	2.2	4.1	6.9	-0.0	2.3	2.6
Arm fat mass (left)	2.2	8.9	13.9	-0.9	3.7	3.5
Unable to work because of sickness or disability	2.2	2.8	4.2	-1.0	-1.8	-2.0
Type 2 Diabetes (T2D) (2012)	2.1	2.5	4.7	0.7	2.2	1.5
Diabetes (mother)	2.1	2.7	3.1	-1.6	1.8	1.6
Number of live births	2.1	2.9	3.7	-1.2	-1.9	-1.9
Illnesses of father: None of the above (group 1)	2.1	2.6	6.4	2.5	-0.1	-1.2
Lupus	2.0	3.0	5.5	2.4	1.6	0.9
Supplements: Zinc	2.0	2.1	5.1	0.1	2.3	1.1
Hair/balding pattern: Pattern 3	2.0	3.1	5.1	1.6	2.3	1.2
Noisy workplace	2.0	2.4	4.0	-1.1	-1.4	-2.0
Impedance of arm (left)	2.0	9.4	17.4	-1.7	-4.2	-2.8
Arm fat mass (right)	2.0	8.4	12.2	-1.3	3.5	3.4
Age at last live birth	2.0	2.8	3.9	1.9	2.0	1.1
Smoking status: Previous	2.0	3.1	4.6	0.1	-2.2	-2.1
Happiness	1.9	2.3	5.6	-0.7	0.9	2.4
Asthma	1.9	3.7	6.3	-0.3	2.5	2.2
Medication: Aspirin	1.9	2.6	4.7	-2.2	-1.7	-0.1
Hair/balding pattern: Pattern 2	1.8	2.3	3.7	-1.7	-1.9	-0.6
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	3.9	2.0	1.5	0.9
Medication: Ramipril	1.8	2.3	3.7	1.2	1.3	1.9
Alcohol intake versus 10 years previously	1.8	2.7	5.7	0.4	2.4	1.5
Arm fat percentage (left)	1.8	7.1	16.3	-4.0	-2.2	-0.4
Asthma (self-reported)	1.8	3.7	6.4	-0.4	2.5	2.1
Medication: Aspirin	1.8	2.4	5.0	-2.2	-1.4	-0.2
Coronary Artery Disease (CAD)	1.7	2.0	2.1	-1.4	1.4	1.4
Type 2 Diabetes (T2D) (2018)	1.7	3.1	4.4	1.1	1.9	2.1
Arm fat percentage (right)	1.7	6.8	15.8	-4.0	-2.1	-0.5
Comparative body size at age 10	1.7	4.6	9.3	-3.0	-2.0	-0.8
Pain type(s) experienced in last month: Hip pain	1.7	2.1	6.2	-2.5	-0.4	0.3
Depression (Nagel 2018)	1.6	2.4	4.5	-0.0	1.7	2.1
Townsend deprivation index at recruitment	1.6	2.2	3.8	-0.4	-1.6	-1.9
Commuting to job workplace: Public transport	1.6	1.9	3.3	0.5	1.8	1.4
Commuting to job workplace: Cycle	1.6	2.0	3.2	0.4	1.8	1.6
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	3.2	1.8	1.6	0.5
Respiratory disease	1.5	3.4	6.8	0.5	2.6	1.7
Age at first live birth	1.5	2.6	5.9	2.4	1.3	0.5
Pulse rate, automated reading	1.5	4.9	6.0	-2.5	-2.1	-2.1
Illnesses of father: Heart disease	1.5	2.1	5.4	-2.3	-0.8	0.5
Loneliness, isolation	1.5	2.0	5.2	-2.3	-0.9	-0.1
Osteoporosis (self-reported)	1.5	1.9	2.4	-1.6	-1.2	-1.3
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	2.2	-1.5	-1.4	-1.1
Had menopause	1.4	1.7	3.3	0.4	1.8	1.3
Allergy	1.4	3.3	4.3	-1.6	-2.1	-1.8
Pulse wave reflection index	1.4	1.7	3.6	0.6	1.9	1.1
Body fat percentage	1.4	5.4	11.8	-3.4	-2.0	-0.3
Wheeze or whistling in the chest in last year	1.4	2.6	4.7	0.6	2.2	1.6
Emphysema/chronic bronchitis	1.4	1.6	2.6	0.8	-1.3	-1.6
Major Depression (MDD)	1.3	1.6	2.4	-1.6	-1.3	-0.8
Blood Eosinophil Count	1.3	10.2	16.8	-2.7	2.5	4.1
Waist Hip Ratio (WHR)	1.3	6.0	13.5	-1.0	-3.7	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	6.1	-1.5	0.8	2.5
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	5.0	-2.2	-0.1	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.1	3.7	-0.9	1.3	1.9
Blood clot in the leg (DVT)	1.3	1.6	2.8	1.7	1.4	0.3
Birth weight	1.3	2.9	4.8	2.2	1.9	-0.4
Shortness of breath walking on level ground	1.3	1.5	4.2	-2.1	-0.4	-0.4
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	4.4	-1.3	-2.1	-0.5
Irritability	1.3	2.2	3.0	1.7	1.1	1.5
Diastolic blood pressure, automated reading	1.3	4.0	11.5	-3.4	-0.1	0.7
Prostate Cancer	1.2	1.7	3.6	0.1	-1.9	-1.3
Systolic Blood Pressure	1.2	6.1	13.6	0.7	3.7	2.0
Number of treatments/medications taken	1.2	2.2	6.4	-2.5	-0.5	0.0
Hayfever, allergic rhinitis or eczema	1.2	2.6	4.6	2.1	1.3	1.3
Stomach or abdominal pain in last month	1.2	1.5	2.8	-1.7	-1.2	-0.5
Illnesses of mother	1.2	1.5	2.5	0.7	1.6	1.3
Chronic bronchitis/emphysema (mother)	1.2	1.5	2.9	0.7	-1.7	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.3	-0.1	1.2	1.8
Friendships satisfaction	1.2	1.5	4.0	-2.0	-0.7	-0.1
Number of self-reported non-cancer illnesses	1.2	2.1	5.6	-2.4	-0.6	-0.5
Bipolar Disorder (2018)	1.1	1.8	5.3	-2.3	0.1	0.4
Ulcerative Colitis (UC)	1.1	2.1	3.8	1.0	1.9	1.2
Age at First Birth	1.1	1.7	4.6	2.1	0.4	-0.5
Average weekly spirits intake	1.1	1.3	2.1	-0.7	-1.2	-1.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.2	-1.8	-1.0	-0.2
Medication: Atenolol	1.1	1.4	2.0	1.2	1.4	0.8
Mouth/teeth dental problems	1.1	1.7	3.5	1.0	1.9	0.9
Lung cancer (father)	1.1	1.3	2.6	1.0	0.4	-1.6
Overall health rating	1.1	2.4	6.1	-2.5	-1.0	0.0
Family relationship satisfaction	1.1	1.4	2.2	-0.1	1.5	1.4
Ever taken oral contraceptive pill	1.1	1.2	1.9	0.5	-1.4	-1.3
Alzheimer’s Disease (in mother)	1.0	1.2	1.8	0.5	-1.2	-1.4
Chronotype (morning person)	1.0	2.3	5.9	0.8	2.4	0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	3.7	-1.5	1.1	1.9
Illnesses of siblings	1.0	1.4	3.8	1.9	0.5	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	2.4	-1.4	0.9	1.6
Breastfed as a baby	1.0	1.2	3.2	1.8	0.4	0.5
Migraine (self-reported)	1.0	1.2	2.0	-0.5	1.2	1.4
Back pain experienced in last month	1.0	1.4	2.0	1.1	-1.0	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	5.5	-0.3	-2.3	-0.8
High cholesterol (Self-reported)	1.0	1.7	3.7	-0.5	-1.9	-1.1
Ever depressed for a whole week	1.0	1.2	1.5	-1.2	-0.9	-1.1
Pain experienced in last month	1.0	1.6	2.3	1.0	1.5	1.2
Leg fat mass (left)	1.0	4.1	6.2	-1.3	2.1	2.5
Schizophrenia vs Biploar Disorder	0.9	1.1	2.4	0.4	-0.9	-1.5
Rheumatoid Arthritis	0.9	1.3	2.3	1.5	1.2	0.2
Smoking Status	0.9	2.2	4.0	-0.6	-1.5	-2.0
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.1	-0.8	0.9	1.5
Fed-up feelings	0.9	1.6	3.0	-1.3	0.1	1.7
Body mass index (BMI)	0.9	3.7	10.1	-3.2	0.0	0.9
Prospective memory result	0.9	1.2	2.5	0.7	-0.7	-1.6
Exposure to tobacco smoke at home	0.9	1.0	2.6	-1.6	0.1	0.7
Leg fat mass (right)	0.9	3.5	5.2	-1.6	1.7	2.3
Had major operations	0.9	1.0	1.7	-0.9	-1.3	-0.7
Illnesses of siblings: Diabetes	0.9	1.1	2.7	-1.6	0.7	0.2
Medication: Gliclazide	0.9	1.0	1.5	-0.4	1.2	1.2
Hearing aid user	0.9	1.0	1.5	1.1	-0.4	-1.2
Medication: Atorvastatin	0.9	1.1	1.5	-1.2	-1.1	-0.7
Basal cell carcinoma (self-reported)	0.9	1.0	2.4	-1.6	-0.8	-0.2
Irritable Bowel Disease (IBD)	0.8	1.9	3.3	1.3	1.8	0.8
Ovarian Cancer	0.8	1.1	1.9	-0.2	-1.4	-1.2
BMI	0.8	4.7	9.1	-3.0	1.2	1.9
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.8	-0.5	-0.9	-1.3
Supplements: Glucosamine	0.8	1.0	1.6	0.2	-1.2	-1.3
Chronic bronchitis/emphysema (father)	0.8	0.9	2.1	-1.4	-0.8	-0.4
Financial difficulties in last 2 years	0.8	1.1	2.6	-1.6	0.5	0.6
Time employed in main current job	0.8	1.0	1.5	-0.2	-1.2	-1.1
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.8	-2.0	1.0	0.1
Medication for pain relief, constipation, heartburn	0.8	1.3	2.2	1.5	1.4	-0.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.3	1.1	-0.7	-1.1
HbA1C	0.7	0.8	1.5	-1.2	-0.9	-0.2
Allergy or Eczema	0.7	1.8	2.7	1.2	1.1	1.7
Neuroticism	0.7	1.7	3.6	-0.7	1.0	1.9
Hearing difficulty/problems: Yes	0.7	1.1	2.4	1.5	-0.5	-0.8
Medication for hormone replacement therapy	0.7	0.8	1.0	-0.9	-1.0	-0.8
Multivitamins +/- minerals	0.7	0.9	2.0	0.4	1.4	0.8
Headache pain in last month	0.7	1.3	1.5	1.0	1.2	1.2
Exposure to tobacco smoke outside home	0.7	0.9	1.3	-0.6	1.0	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.1	-0.1	-0.3	-1.5
Medication: Seretide 50 evohaler	0.7	0.8	1.4	-0.8	1.2	0.7
Heart disease (mother)	0.7	0.9	1.7	-1.3	-0.9	-0.3
Eye problems/disorders: Glaucoma	0.7	0.9	2.1	-0.5	-1.5	-0.5
Vascular/heart problems diagnosed by doctor	0.7	1.9	5.2	2.3	0.6	-0.1
Breast Cancer	0.6	1.6	2.3	0.6	-1.5	-1.4
Blood Platelet Count	0.6	7.5	11.1	0.6	3.3	3.3
Trunk fat percentage	0.6	2.5	6.7	-2.6	-0.1	0.9
Maternal smoking around birth	0.6	0.8	1.3	-1.2	-1.0	-0.3
Medication: Cholesterol lowering	0.6	0.9	1.8	-0.4	-1.3	-0.8
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	0.0	1.2	0.9
Birth weight of first child	0.6	1.1	2.3	-0.2	-1.0	-1.5
Health satisfaction	0.6	0.7	1.2	-0.9	0.4	1.1
Mineral and other dietary supplements	0.6	0.8	1.6	0.1	1.3	0.9
Miserableness	0.6	1.1	1.8	-1.3	0.3	1.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.7	0.2	0.7	1.3
Heart disease (siblings)	0.6	0.7	1.6	-1.3	-0.5	-0.5
Body Mass Index (BMI) (2010)	0.5	0.7	1.5	-1.2	0.3	0.7
Mean Putamen Volume	0.5	0.6	1.2	1.1	0.6	0.4
Heel T-Score	0.5	3.6	6.7	-2.6	-0.8	1.8
Cardiovascular Disease	0.5	1.8	4.8	-2.2	-0.8	0.2
Hypothyroidism (self reported)	0.5	1.2	2.8	-1.7	0.7	-0.6
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-0.2	-0.4	-1.2
Systolic blood pressure, automated reading	0.5	1.3	3.3	0.1	1.8	0.9
Current tobacco smoking	0.5	0.8	1.1	-1.1	-0.5	-1.0
High blood pressure	0.5	1.4	3.7	-1.9	-0.6	-0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	-0.7	1.0	0.5
Number of children fathered	0.5	0.6	1.8	1.3	0.1	0.1
Hypertension (Self-reported)	0.5	1.5	3.6	-1.9	-0.7	-0.6
Mood swings	0.5	0.9	1.7	-0.8	0.7	1.3
Average weekly champagne plus white wine intake	0.5	0.6	1.5	-0.1	1.2	0.6
Mother’s age at death	0.5	0.7	1.2	0.7	-0.5	-1.1
Medication: Paracetamol	0.5	0.7	2.0	-1.4	-0.1	0.4
Pack years of smoking	0.5	0.7	1.0	-0.5	0.8	1.0
Bipolar Disorder or Schizophrenia	0.4	0.9	2.1	-1.5	0.5	0.5
Depressed Affect (Nagel 2018)	0.4	0.8	2.0	-0.6	0.1	1.4
Pack years adult smoking proportion	0.4	0.6	1.0	-0.6	0.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.9	-0.6	0.6	0.9
Medication: Levothyroxine sodium	0.4	0.7	1.4	-1.2	0.8	-0.1
High blood pressure (mother)	0.4	0.5	1.5	0.2	1.2	0.1
Hearing difficulty/problems with background noise	0.4	0.7	1.8	1.3	-0.2	-0.4
Medication: Simvastatin	0.4	0.6	0.7	0.8	-0.8	-0.7
Neuroticism score	0.4	0.8	2.2	-0.5	0.4	1.5
Worrier / anxious feelings	0.4	0.7	1.1	0.4	0.9	1.1
Medication: Paracetamol	0.4	0.6	1.6	-1.2	-0.6	0.2
Eye problems/disorders: None of the above	0.4	0.4	0.8	0.6	0.9	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.7	-0.1	-0.9	-0.7
Leg pain on walking	0.4	0.4	0.8	-0.9	-0.7	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.6	-0.8	-0.8	-0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.6	-0.7	-0.8	-0.5
Smoking status: Current	0.4	0.7	1.0	-0.8	-0.5	-1.0
Medication: Blood pressure	0.4	0.8	1.4	-0.1	1.0	1.2
Ever smoked	0.4	0.7	1.6	0.5	-0.6	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.2	-1.1	-0.4	0.0
Alcohol drinker status: Previous	0.4	0.4	0.6	0.6	0.6	-0.8
Worry (Nagel 2018)	0.3	0.7	1.4	0.6	0.6	1.2
Crohns Disease (2017)	0.3	0.6	1.3	1.1	0.6	-0.2
Crohns Disease (2012)	0.3	0.5	1.0	0.5	1.0	0.6
Fasting Glucose	0.3	0.3	0.6	0.8	0.5	0.4
Triglycerides	0.3	0.5	0.8	-0.3	-0.9	-0.8
Taking other prescription medications	0.3	0.5	1.4	-1.2	0.2	0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	0.1	-0.7	-0.6
Father’s age at death	0.3	0.4	0.7	0.8	0.6	-0.2
Loud music exposure frequency	0.3	0.4	0.8	-0.3	-0.9	-0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	0.7	0.6	0.8	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	-0.8	-0.5	-0.1
Eye problems/disorders: Cataract	0.3	0.4	0.6	-0.5	0.5	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	-0.6	0.1	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	0.2	-1.0	-0.4
Neuroticism (Nagel 2018)	0.2	0.4	0.9	0.5	0.1	0.9
Neuroticism (2016)	0.2	0.3	0.6	-0.4	0.3	0.8
Primary Biliary Cirrhosis	0.2	0.3	0.5	-0.6	0.3	0.7
Blood Red Count	0.2	2.0	3.2	-1.8	-1.6	-0.7
Serious illness, injury or assault to yourself	0.2	0.3	0.4	-0.4	-0.5	-0.6
Had other major operations	0.2	0.2	0.5	0.2	-0.7	-0.4
Heart attack	0.2	0.3	0.5	-0.7	-0.5	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.8	0.4	-0.4
Tense / ‘highly strung’	0.2	0.4	0.7	-0.7	0.1	0.8
Medication: Allopurinol	0.2	0.3	0.6	-0.3	-0.8	0.2
Medication: Omeprazole	0.2	0.2	0.5	-0.7	-0.4	-0.1
Suffer from ‘nerves’	0.2	0.4	0.9	-0.3	0.2	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	-0.5	-0.5	-0.3
Qualifications: nursing, teaching	0.2	0.3	0.5	0.0	0.7	0.7
Medication for cholesterol	0.2	0.3	0.5	0.7	0.4	-0.4
Breast cancer (self-reported)	0.2	0.3	0.5	0.3	0.7	0.5
Guilty feelings	0.2	0.3	0.6	0.8	0.3	0.3
Medication: Bendroflumethiazide	0.2	0.3	0.4	-0.5	0.6	0.4
Medication: Lisinopril	0.2	0.3	0.7	-0.8	0.1	0.5
Illnesses of father: High blood pressure	0.2	0.3	0.8	-0.9	0.1	0.1
Risk taking	0.2	0.3	0.5	-0.2	0.7	0.6
Cholesterol lowering medication	0.2	0.3	0.9	0.0	-0.9	-0.1
Supplements: Calcium	0.2	0.3	0.6	-0.8	-0.2	-0.4
Schizophrenia (2018)	0.1	0.1	0.3	-0.1	0.5	0.3
Bipolar Disorder (2011)	0.1	0.1	0.2	0.0	0.4	0.0
Schizophrenia (2014)	0.1	0.2	0.3	-0.4	0.6	0.4
Blood White Count	0.1	1.1	2.8	-1.7	-0.4	-0.5
Vitamin and mineral supplements	0.1	0.1	0.1	-0.2	-0.3	0.2
Average weekly fortified wine intake	0.1	0.1	0.4	0.6	0.1	-0.1
Nervous feelings	0.1	0.2	0.2	0.4	-0.4	0.3
Pain all over the body in last month	0.1	0.1	0.4	-0.6	-0.1	-0.0
Falls in the last year	0.1	0.1	0.3	-0.3	-0.5	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.6	0.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	0.6	-0.4	-0.0
Depression (self-reported)	0.1	0.1	0.3	0.0	-0.6	-0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	0.9	-0.0	-0.4
Gout (self-reported)	0.1	0.1	0.4	0.2	-0.6	-0.1
Medication: Amlodipine	0.1	0.2	0.6	-0.8	0.0	-0.1
High blood pressure (siblings)	0.1	0.1	0.2	-0.4	0.2	0.4
Worry too long after embarrassment	0.1	0.2	0.5	0.2	-0.2	0.7
Pulse wave peak to peak time	0.1	0.2	0.3	0.6	0.4	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.3	0.3	-0.5
Neck or shoulder pain in last month	0.1	0.2	0.3	-0.4	0.5	0.4
Medication: Blood pressure	0.1	0.2	0.7	-0.8	0.0	0.2
Angina (self-reported)	0.1	0.2	0.4	-0.0	0.6	0.4
Medication: Ibuprofen	0.1	0.1	0.1	0.4	0.0	0.3
Alcohol intake frequency.	0.1	0.3	0.7	-0.8	-0.5	0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.3	-0.4	0.1
Supplements: Vitamin C	0.1	0.1	0.1	-0.4	0.3	-0.1
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.4	0.4	-0.1
Ever had bowel cancer screening	0.1	0.1	0.2	-0.4	0.1	0.5
Alcohol drinker status: Never	0.1	0.1	0.3	-0.4	-0.5	0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.2	-0.5	-0.3	-0.4
Angina	0.0	0.0	0.0	-0.0	0.2	0.2
Severe depression (siblings)	0.0	0.0	0.1	-0.2	0.0	-0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.3	0.0	0.1
Glaucoma (self-reported)	0.0	0.0	0.1	-0.0	-0.2	0.1
Number of full brothers	0.0	0.0	0.0	-0.2	0.0	0.2
Financial situation satisfaction	0.0	0.1	0.1	-0.4	0.0	0.1
Fractured/broken bones in last 5 years	0.0	0.0	0.1	-0.2	-0.1	0.2

Hub : Genes

NFS1

Models

Trait associations