TWAS hub - NGF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.314	0.067	3.2e-07	0.111	NA	0.113	NA	0.090	1.1e-08	NA	8.5e-09	NA	2.9e-07
2	GTEx	Whole Blood	0.135	0.053	8.7e-03	0.002	NA	0.000	NA	0.003	2.0e-01	NA	2.9e-01	NA	1.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder (2011)	11.0	10.6	12.6	3.6	2.9
Medication for cholesterol, blood pressure or diabetes	8.0	13.2	22.7	-4.8	-2.0
Medication: Blood pressure	7.0	12.4	20.3	4.5	2.1
Type 2 Diabetes (T2D) (2012)	6.3	7.3	12.6	3.6	1.4
Hayfever/allergic rhinitis (self-reported)	5.4	7.1	7.7	2.6	2.8
Medication: Metformin	5.0	7.1	10.4	3.2	1.9
High blood pressure	5.0	14.0	28.0	5.3	0.2
Diabetes (self-reported)	4.7	7.3	9.4	3.1	2.3
Hypertension (Self-reported)	4.5	12.5	24.9	5.0	-0.2
High cholesterol (Self-reported)	4.1	7.2	12.9	3.6	1.2
Diabetes diagnosed by doctor	3.9	6.5	9.2	3.0	1.9
Vascular/heart problems diagnosed by doctor	3.8	10.5	21.0	-4.6	0.1
Bipolar Disorder (2018)	3.4	5.4	9.7	3.1	1.0
Cardiovascular Disease	3.4	11.3	22.7	4.8	-0.1
Medication: Cholesterol lowering	3.1	4.9	8.9	3.0	0.9
Medication: Bendroflumethiazide	3.1	4.8	8.6	2.9	0.9
Back pain experienced in last month	3.0	4.3	4.9	2.2	1.9
Other serious medical condition/disability diagnosed by doctor	2.9	3.7	7.3	-0.4	-2.7
Medication: Ramipril	2.9	3.8	7.5	2.7	-0.3
Loud music exposure frequency	2.9	3.2	3.8	-1.6	-2.0
Breast cancer (self-reported)	2.8	3.3	3.9	2.0	1.7
Medication: Gliclazide	2.8	3.1	3.5	1.7	1.9
Osteoporosis (self-reported)	2.7	3.4	5.0	-2.2	-1.3
Pain type(s) experienced in last month: Hip pain	2.7	3.5	6.9	-0.2	-2.6
Medication: Ventolin 100micrograms inhaler	2.6	3.3	3.7	1.9	-1.7
Heart disease (mother)	2.5	3.0	3.5	-1.6	-1.9
Hand grip strength (left)	2.4	6.2	12.2	-3.5	-0.4
Diabetes (mother)	2.4	3.1	6.0	2.4	0.4
Pulse rate	2.3	3.9	5.0	-1.7	-2.2
Number of self-reported non-cancer illnesses	2.3	4.1	7.7	2.8	0.7
Bipolar Disorder or Schizophrenia	2.2	5.4	10.0	3.2	0.8
Major Depression (MDD)	2.2	2.6	3.1	1.5	1.8
Average weekly champagne plus white wine intake	2.2	3.0	5.7	-0.5	2.4
Lung FVC	2.1	10.6	14.9	-3.9	-2.5
Mouth/teeth dental problems	2.1	3.2	5.8	2.4	0.7
Medication for cholesterol	2.1	3.2	5.0	-1.2	2.2
Medication: Lisinopril	2.1	2.7	3.5	1.9	1.4
Medication for hormone replacement therapy	2.0	2.2	4.4	-0.2	-2.1
Hearing aid user	1.9	2.1	3.8	-0.6	-2.0
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	4.6	-2.1	-0.3
Tinnitus: Yes, now most or all of the time	1.8	2.1	4.0	2.0	-0.6
Depression (Nagel 2018)	1.7	2.6	2.7	1.6	1.6
Ovarian Cancer	1.7	2.3	3.2	1.8	-1.2
Schizophrenia (2014)	1.7	3.9	7.6	2.8	0.4
Average weekly spirits intake	1.7	2.1	3.8	-0.6	-2.0
Hand grip strength (right)	1.7	4.7	9.3	-3.0	-0.2
Relative age voice broke	1.7	2.5	5.0	-0.3	2.2
Medication: Paracetamol	1.7	2.8	5.0	-2.2	-0.8
Gout (self-reported)	1.7	2.3	4.5	2.1	0.1
Supplements: Vitamin C	1.7	2.0	2.7	-1.2	1.6
Irritability	1.7	2.8	5.0	0.8	2.2
Ever had prostate specific antigen (PSA) test	1.7	1.9	3.7	1.9	0.4
Alcohol drinker status: Previous	1.7	2.0	3.2	-0.9	-1.8
Overall health rating	1.6	3.4	5.5	1.1	-2.3
Average weekly beer plus cider intake	1.6	2.4	4.6	0.4	-2.1
Systolic Blood Pressure	1.5	7.6	15.2	3.9	-0.0
Leg pain on walking	1.5	1.8	3.3	1.8	0.6
Illnesses of father: None of the above (group 1)	1.5	1.8	3.6	-1.9	-0.3
Miserableness	1.5	2.6	3.7	1.2	1.9
Lung FEV1/FVC ratio	1.4	7.3	7.8	2.8	2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.1	1.8	0.5
Pulse rate, automated reading	1.4	4.6	4.9	-2.2	-2.1
Neuroticism (Nagel 2018)	1.3	3.0	4.6	1.1	2.2
Primary Biliary Cirrhosis	1.3	1.9	1.9	1.4	1.3
Type 2 Diabetes (T2D) (2018)	1.3	2.5	3.2	1.8	1.4
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.7	-0.6	-1.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	3.0	0.3	-1.7
Hair/balding pattern: Pattern 3	1.3	1.9	3.7	-1.9	-0.1
Medication: Amlodipine	1.3	1.9	3.5	1.9	-0.5
Number of children fathered	1.3	1.4	1.5	1.2	1.2
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.1	-0.2	1.8
Friendships satisfaction	1.3	1.6	1.6	-1.3	-1.3
Mineral and other dietary supplements	1.3	1.8	2.4	1.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	3.1	-1.6	-1.8
Eye problems/disorders: Glaucoma	1.3	1.6	2.2	-1.0	-1.5
Taking other prescription medications	1.2	1.8	1.8	1.3	-1.4
Illnesses of siblings	1.2	1.7	3.5	-1.9	-0.0
Forced vital capacity (FVC), Best measure	1.2	4.5	6.9	-2.6	-1.5
Worry too long after embarrassment	1.2	2.0	3.0	1.7	1.0
Medication: Blood pressure	1.2	2.2	3.4	1.8	-1.0
Chronotype (morning person)	1.1	2.5	5.0	2.2	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.0	0.7	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	5.9	-2.4	-0.9
Medication for pain relief, constipation, heartburn	1.1	1.8	2.3	1.5	1.2
Migraine (self-reported)	1.1	1.4	2.5	-1.6	-0.4
Illnesses of father: High blood pressure	1.1	1.3	1.9	1.4	0.9
Heart disease (siblings)	1.1	1.4	2.3	1.5	0.6
Number of treatments/medications taken	1.0	1.8	3.5	1.9	-0.3
Relative age of first facial hair	1.0	2.0	3.7	0.6	1.9
Systolic blood pressure, automated reading	1.0	2.9	5.7	2.4	-0.2
Vitamin and mineral supplements	1.0	1.3	2.3	1.5	0.5
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.0	-1.4	-0.4
Hayfever, allergic rhinitis or eczema	1.0	2.2	2.9	1.2	1.7
High blood pressure (mother)	1.0	1.4	1.7	1.3	-1.1
Father’s age at death	1.0	1.3	2.6	0.0	1.6
Blood clot in the leg (DVT)	1.0	1.3	2.3	1.5	-0.6
Headache pain in last month	1.0	1.8	3.4	-1.9	-0.3
Wheeze or whistling in the chest in last year	1.0	1.7	3.5	1.9	0.0
Angina (self-reported)	1.0	1.3	2.6	-0.2	-1.6
Age at last live birth	1.0	1.4	2.8	-1.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.6	-0.9	-1.3
Smoking status: Current	1.0	1.7	1.7	1.3	1.3
Medication: Paracetamol	1.0	1.6	2.9	-1.7	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.5	1.6	-0.5
Coronary Artery Disease (CAD)	0.9	1.0	2.0	-0.3	1.4
Crohns Disease (2012)	0.9	1.5	1.9	-1.1	1.4
Rheumatoid Arthritis	0.9	1.2	2.3	-1.5	0.3
Angina	0.9	1.2	2.3	-0.3	-1.5
Diabetes (father)	0.9	1.2	2.0	0.6	1.4
Maternal smoking around birth	0.9	1.3	1.9	-0.8	1.4
Forced vital capacity (FVC)	0.9	3.4	4.5	-2.1	-1.5
Medication: Simvastatin	0.9	1.4	2.8	1.7	-0.1
Illnesses of mother	0.9	1.2	2.3	-1.5	0.0
Pulse wave Arterial Stiffness index	0.9	1.1	2.0	0.4	-1.4
Leg fat percentage (right)	0.9	3.4	3.5	1.9	-1.8
Medication: Allopurinol	0.9	1.2	2.5	1.6	0.0
Average weekly red wine intake	0.9	1.3	2.4	-1.6	-0.4
Ever had bowel cancer screening	0.9	1.1	1.7	0.6	1.3
Qualifications: nursing, teaching	0.9	1.5	2.9	0.3	1.7
Severe depression (siblings)	0.8	0.9	1.8	1.4	0.0
Chronic bronchitis/emphysema (father)	0.8	1.0	2.0	1.4	0.0
Hair/balding pattern: Pattern 2	0.8	1.0	1.4	1.2	-0.7
Allergy	0.8	1.9	3.6	-1.9	-0.4
Asthma	0.8	1.5	1.6	1.2	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.8	0.5	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.5	1.2	0.7
Leg fat percentage (left)	0.8	3.0	3.2	1.8	-1.7
Number of operations (self-reported)	0.8	1.1	1.2	1.1	-1.0
Diastolic blood pressure, automated reading	0.8	2.6	5.0	-0.3	-2.2
Crohns Disease (2017)	0.7	1.5	2.2	-0.9	1.5
Body Mass Index (BMI) (2010)	0.7	1.0	1.6	-1.3	0.6
Blood Eosinophil Count	0.7	5.5	8.0	2.8	1.8
Blood White Count	0.7	5.5	10.6	3.2	0.6
Medication: Co-codamol	0.7	0.8	1.2	0.5	1.1
Pulse wave peak to peak time	0.7	0.9	1.6	-0.4	1.3
Mean time to correctly identify matches	0.7	1.4	1.9	1.4	0.9
Number of full sisters	0.7	0.8	1.4	0.5	1.2
Long-standing illness, disability or infirmity	0.7	1.0	1.9	1.4	0.3
Asthma (self-reported)	0.7	1.4	2.2	1.5	-0.8
Wears glasses or contact lenses	0.7	0.9	1.7	-0.2	-1.3
Supplements: Fish oil (including cod liver oil)	0.7	1.0	1.7	-1.3	-0.4
Medication: Atorvastatin	0.7	0.9	1.2	1.1	0.8
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.1	-0.7	-1.1
Serious illness, injury or assault to yourself	0.6	0.7	1.4	1.2	0.1
Multivitamins +/- minerals	0.6	0.7	1.1	-0.6	-1.1
Stomach or abdominal pain in last month	0.6	0.8	1.5	0.3	1.2
Had other major operations	0.6	0.7	1.3	0.4	-1.1
Glaucoma (self-reported)	0.6	0.7	0.9	-0.9	-0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.0	-0.6	1.0
Eye problems/disorders: None of the above	0.6	0.7	0.8	0.9	0.7
Illnesses of siblings: Diabetes	0.6	0.7	1.4	1.2	-0.2
Ever smoked	0.6	1.1	1.8	-0.6	1.4
Schizophrenia (2018)	0.5	1.1	2.1	1.4	0.2
Worry (Nagel 2018)	0.5	1.1	1.8	0.5	1.4
Irritable Bowel Disease (IBD)	0.5	1.1	1.2	-1.1	1.0
Mean Putamen Volume	0.5	0.5	0.6	-0.7	0.7
HDL Cholesterol	0.5	0.8	1.0	-0.8	-1.0
Ulcerative Colitis	0.5	0.8	1.1	1.1	0.6
Blood Red Count	0.5	5.0	9.1	3.0	0.9
Respiratory disease	0.5	1.1	1.2	1.0	-1.1
Hearing difficulty/problems: Yes	0.5	0.8	1.1	-0.7	-1.1
Impedance of leg (right)	0.5	2.3	4.7	-0.1	-2.2
Impedance of leg (left)	0.5	2.4	4.7	-0.4	-2.2
Number of incorrect matches in round	0.5	0.9	1.5	-0.5	-1.2
Past tobacco smoking	0.5	0.9	1.5	0.5	-1.2
Arm fat percentage (right)	0.5	1.9	3.4	1.9	-0.6
Happiness	0.5	0.6	1.0	1.0	0.5
Prospective memory result	0.5	0.6	1.2	-1.1	0.3
Lung cancer (father)	0.5	0.6	0.8	-0.6	-0.9
Birth weight of first child	0.5	0.9	1.5	-1.2	0.5
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.0	0.2	1.0
Body fat percentage	0.5	2.0	2.9	1.7	-1.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.1	0.4	-1.0
Leg fat mass (right)	0.5	2.0	2.5	1.6	-1.2
Mood swings	0.5	1.0	1.8	-1.3	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	0.7	-0.7	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.3	-1.1	0.4
Fractured/broken bones in last 5 years	0.5	0.7	1.3	1.1	-0.2
Depressed Affect (Nagel 2018)	0.4	0.9	1.5	0.5	1.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	0.2	1.0
Reaction Time	0.4	0.7	1.3	1.2	0.3
BMI	0.4	2.6	3.3	1.8	1.3
Allergy or Eczema	0.4	1.1	1.3	0.9	1.1
Trunk fat percentage	0.4	1.6	2.9	1.7	-0.6
Current tobacco smoking	0.4	0.7	0.8	0.9	0.8
Medication: Atenolol	0.4	0.5	0.9	-0.9	-0.3
Sitting height	0.4	3.2	3.8	2.0	1.6
Waist circumference	0.4	1.6	2.9	1.7	-0.6
Heart attack	0.4	0.6	0.9	-0.4	-1.0
Time employed in main current job	0.4	0.5	0.8	-0.9	0.5
Medication: Lansoprazole	0.4	0.5	0.9	-0.3	1.0
Arm fat mass (right)	0.4	1.5	2.7	1.6	-0.5
Birth weight	0.4	0.8	1.5	0.3	1.2
High blood pressure (siblings)	0.4	0.5	0.7	0.9	-0.6
Number of full brothers	0.4	0.6	0.9	-0.5	-1.0
Health satisfaction	0.4	0.5	0.8	0.9	-0.5
Chest pain or discomfort	0.4	0.5	0.8	0.5	0.9
Had major operations	0.4	0.5	0.5	0.7	0.7
Arm fat percentage (left)	0.4	1.6	2.9	1.7	-0.6
Financial situation satisfaction	0.4	0.5	0.9	1.0	-0.2
Age started oral contraceptive pill	0.4	0.5	1.0	-0.2	1.0
Myopia	0.4	0.5	0.6	-0.8	-0.6
Supplements: Calcium	0.4	0.4	0.8	-0.9	-0.1
Leg fat mass (left)	0.4	1.6	2.1	1.4	-1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	0.9	-0.0
Ulcerative Colitis (UC)	0.3	0.5	0.8	-0.9	0.5
Breast Cancer	0.3	0.7	1.3	-0.2	-1.2
LDL Cholesterol	0.3	0.4	0.5	0.5	-0.7
Lupus	0.3	0.4	0.7	-0.2	0.9
Heel T-Score	0.3	2.1	2.7	1.6	-1.2
Tanning	0.3	3.4	5.5	-1.1	-2.4
Supplements: Zinc	0.3	0.3	0.6	-0.8	0.2
Fed-up feelings	0.3	0.5	0.7	0.8	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	0.9	0.1
Supplements: Glucosamine	0.3	0.4	0.6	-0.3	-0.8
Trunk fat mass	0.3	1.2	2.1	1.4	-0.6
Alcohol usually taken with meals	0.3	0.6	1.1	0.2	1.0
Hearing difficulty/problems with background noise	0.3	0.5	0.8	0.5	0.9
Had menopause	0.3	0.4	0.7	0.4	-0.8
Fluid intelligence score	0.3	0.7	1.3	-0.0	-1.2
Worrier / anxious feelings	0.3	0.5	1.0	0.3	1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.6	-1.3	-0.8
Depression (self-reported)	0.3	0.4	0.7	0.2	0.8
Length of working week for main job	0.3	0.3	0.3	-0.6	-0.5
Hair/balding pattern: Pattern 4	0.3	0.7	1.3	-0.1	-1.1
Pulse wave reflection index	0.3	0.3	0.5	-0.4	0.7
Age at first live birth	0.3	0.5	0.8	-0.9	0.4
Neck or shoulder pain in last month	0.3	0.5	0.9	-0.9	-0.3
Medication: Ibuprofen	0.3	0.3	0.5	-0.7	0.3
Whole body fat mass	0.3	1.4	2.5	1.6	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	0.2	0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	-0.8	0.2
Knee pain experienced in last month	0.3	0.4	0.9	0.1	-0.9
Smoking status: Previous	0.3	0.4	0.7	-0.8	0.4
Eye problems/disorders: Cataract	0.3	0.4	0.5	-0.7	-0.4
Commuting to job workplace: Public transport	0.3	0.3	0.7	-0.8	-0.2
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	-0.1	0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.6	-0.2	-0.8
Pack years of smoking	0.3	0.5	0.8	-0.4	-0.9
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	0.7	-0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.5	-0.4
Smoking Status	0.2	0.5	1.0	-0.2	1.0
Hypothyroidism (self reported)	0.2	0.5	1.1	-1.0	0.1
Sensitivity / hurt feelings	0.2	0.4	0.5	-0.7	-0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	0.5	0.6
Pack years adult smoking proportion	0.2	0.3	0.6	-0.2	-0.7
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.3	-0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	0.6	-0.2
Medication: Levothyroxine sodium	0.2	0.3	0.3	-0.6	-0.4
Body mass index (BMI)	0.2	0.7	1.3	1.1	-0.2
Pain all over the body in last month	0.2	0.2	0.3	0.5	-0.2
Impedance of arm (right)	0.2	1.0	2.0	1.4	0.3
Noisy workplace	0.2	0.3	0.4	0.6	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	-0.7	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.6	-0.2
Breastfed as a baby	0.2	0.2	0.4	0.6	0.1
Tense / ‘highly strung’	0.2	0.3	0.5	0.4	0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.5	-0.7	-0.3
Comparative body size at age 10	0.2	0.6	0.7	0.7	0.8
Shortness of breath walking on level ground	0.2	0.3	0.4	-0.4	0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.1	-0.7
Comparative height size at age 10	0.2	1.1	1.3	-1.1	-0.9
Medication: Aspirin	0.2	0.3	0.3	0.6	-0.4
Illnesses of father: Heart disease	0.2	0.2	0.5	0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.6	-0.5	-0.8
Arm fat mass (left)	0.2	0.9	1.7	1.3	-0.4
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.6	0.0
Alcohol drinker status: Never	0.2	0.2	0.4	0.6	0.1
Risk taking	0.2	0.3	0.5	0.7	0.3
Ever depressed for a whole week	0.2	0.2	0.2	0.4	-0.5
Cholesterol lowering medication	0.2	0.4	0.4	0.5	-0.6
Pain experienced in last month	0.2	0.4	0.7	-0.9	-0.0
Prostate Cancer	0.1	0.1	0.1	0.4	-0.3
Age at First Birth	0.1	0.1	0.2	-0.5	-0.1
Fasting Glucose	0.1	0.1	0.1	0.4	-0.2
Neuroticism (2016)	0.1	0.1	0.2	-0.4	0.0
Triglycerides	0.1	0.1	0.2	0.4	-0.2
Blood Platelet Count	0.1	0.8	1.0	0.7	1.0
Waist Hip Ratio (WHR)	0.1	0.4	0.7	-0.2	-0.9
Hair Pigment	0.1	2.9	3.4	-1.9	-1.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	-0.0	-0.4
Leg fat-free mass (left)	0.1	0.7	1.3	0.4	1.1
Age when periods started (menarche)	0.1	0.1	0.2	-0.3	-0.4
Leg predicted mass (left)	0.1	0.6	1.0	0.4	1.0
Nervous feelings	0.1	0.2	0.3	0.5	0.5
Qualifications: None of the above	0.1	0.1	0.3	-0.0	0.5
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.4	0.2
Neuroticism score	0.1	0.1	0.1	0.4	0.4
Weight	0.1	0.4	0.8	0.9	-0.1
Trunk fat-free mass	0.1	0.4	0.7	-0.8	0.2
Hip circumference	0.1	0.2	0.3	0.5	-0.4
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.1	-0.5
Falls in the last year	0.1	0.1	0.1	-0.3	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	-0.8	-0.1
Impedance of arm (left)	0.1	0.3	0.6	0.8	0.2
Trunk predicted mass	0.1	0.4	0.7	-0.8	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.2	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.5	-0.2
Arm fat-free mass (right)	0.1	0.6	1.1	-1.0	-0.3
Exposure to tobacco smoke outside home	0.1	0.1	0.1	-0.1	-0.4
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.1	-0.3
Medication: Omeprazole	0.1	0.1	0.2	-0.4	0.2
Arm predicted mass (right)	0.1	0.4	0.6	-0.8	-0.4
Family relationship satisfaction	0.1	0.1	0.1	-0.3	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.5	-0.1
Leg fat-free mass (right)	0.1	0.8	1.5	0.2	1.2
Loneliness, isolation	0.1	0.1	0.2	-0.4	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.5	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	0.3	0.3
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.1	-0.4
Medication: Aspirin	0.1	0.1	0.2	0.1	-0.5
Leg predicted mass (right)	0.1	0.8	1.5	0.2	1.2
Guilty feelings	0.1	0.1	0.2	0.4	-0.0
Commuting to job workplace: Cycle	0.1	0.2	0.3	-0.2	0.5
Impedance of whole body	0.1	0.7	1.5	0.1	-1.2
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	-0.4	-0.3
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.1	-0.2	-0.2
HbA1C	0.0	0.0	0.0	-0.2	0.1
Height	0.0	0.3	0.4	-0.6	-0.4
Neuroticism	0.0	0.1	0.2	0.1	0.4
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.2	-0.1
Average weekly fortified wine intake	0.0	0.0	0.1	0.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	0.4	-0.2
Qualifications: CSEs or equivalent	0.0	0.0	0.0	0.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	-0.4	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	0.2	-0.0
Number of live births	0.0	0.0	0.0	0.2	-0.2
Standing height	0.0	0.1	0.3	-0.5	0.1
Peak expiratory flow (PEF)	0.0	0.0	0.1	0.3	-0.0
Qualifications: College or University degree	0.0	0.1	0.1	0.3	0.3
Alcohol intake frequency.	0.0	0.0	0.1	-0.3	-0.1
Suffer from ‘nerves’	0.0	0.1	0.1	0.2	-0.3
Whole body fat-free mass	0.0	0.2	0.3	-0.4	0.6
Whole body water mass	0.0	0.2	0.2	-0.4	0.5
Mother’s age at death	0.0	0.0	0.0	0.0	0.0
Basal metabolic rate	0.0	0.1	0.2	-0.0	0.4
Arm fat-free mass (left)	0.0	0.2	0.3	-0.5	-0.5
Unable to work because of sickness or disability	0.0	0.0	0.0	-0.0	0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.1	-0.3	-0.1
Arm predicted mass (left)	0.0	0.2	0.3	-0.5	-0.4

Hub : Genes

NGF

Models

Trait associations