Hub : Genes

NGRN

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Pheochromocytoma and Paraganglioma 0.112 0.064 0.0062 0.011 0.058 0.041 NA 0.023 0.11 0.0024 0.0098 NA 0.04
2 TCGA Thyroid Carcinoma 0.067 0.039 0.0099 0.000 0.006 0.001 NA 0.002 0.31 0.0790 0.2500 NA 0.21

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.4 0.7 0.0 0.9
Bipolar Disorder or Schizophrenia 0.3 0.8 1.5 -1.2 0.3
Depressed Affect (Nagel 2018) 0.2 0.5 0.7 -0.5 -0.8
Depression (Nagel 2018) 0.0 0.0 0.1 -0.1 -0.2
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.0 0.8 1.0
Neuroticism (Nagel 2018) 0.1 0.3 0.6 0.0 -0.8
Schizophrenia (2018) 0.6 1.3 2.6 -1.6 -0.3
Schizophrenia vs Biploar Disorder 0.7 0.9 1.5 0.6 -1.2
Worry (Nagel 2018) 0.6 1.2 1.3 1.1 -1.0
Alzheimer’s Disease (in mother) 0.5 0.6 1.2 -0.2 1.1
Alzheimer’s Disease (in father) 0.1 0.1 0.2 -0.4 0.2
Alzheimer’s Disease (including proxy) 1.1 1.6 2.4 -0.8 1.6
Crohns Disease (2017) 0.0 0.1 0.1 0.3 0.2
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 -0.7 -0.2
Ulcerative Colitis (UC) 0.9 1.8 3.5 -1.9 0.0
Major Depression (MDD) 0.8 1.0 1.8 0.3 -1.3
Reaction Time 0.0 0.0 0.0 -0.2 0.0
Verbal and Numeric Reasoning (VNR) 0.4 1.1 1.9 1.4 0.5
Breast Cancer 1.0 2.4 2.7 1.6 -1.4
Ovarian Cancer 0.5 0.7 1.1 0.5 -1.0
Prostate Cancer 0.4 0.5 1.0 1.0 -0.0
Age at First Birth 1.9 2.7 4.5 1.0 2.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.5 3.4 5.0 -2.2 -1.3
Coronary Artery Disease (CAD) 0.5 0.6 1.2 -1.1 -0.2
Crohns Disease (2012) 0.1 0.1 0.2 0.3 0.4
Mean Putamen Volume 0.9 1.1 2.0 1.4 -0.5
Fasting Glucose 0.0 0.1 0.1 0.3 -0.1
HbA1C 0.8 0.9 1.3 -1.1 -0.8
HDL Cholesterol 0.4 0.6 1.0 1.0 -0.4
LDL Cholesterol 0.1 0.2 0.4 0.1 0.6
Lupus 0.1 0.2 0.3 0.5 -0.3
Neuroticism (2016) 0.0 0.0 0.0 0.2 -0.1
Primary Biliary Cirrhosis 0.0 0.0 0.1 0.1 0.2
Rheumatoid Arthritis 2.1 2.9 5.1 -2.3 -0.9
Schizophrenia (2014) 0.1 0.2 0.3 -0.5 0.3
Triglycerides 0.2 0.4 0.6 0.4 0.8
Type 2 Diabetes (T2D) (2012) 0.9 1.1 1.4 -0.9 -1.2
Ulcerative Colitis 1.2 1.8 2.9 -1.7 -0.8
Blood Eosinophil Count 0.2 1.5 2.9 -1.7 0.1
Blood Platelet Count 0.4 4.5 8.6 0.6 2.9
Blood Red Count 0.7 6.8 8.3 2.3 -2.9
Blood White Count 0.1 0.5 0.9 -0.9 -0.4
Heel T-Score 5.8 46.3 80.5 9.0 3.5
BMI 0.6 3.2 4.8 -2.2 1.3
Height 0.3 5.1 10.2 -0.3 -3.2
Waist Hip Ratio (WHR) 0.5 2.0 3.3 0.9 -1.8
Systolic Blood Pressure 1.1 5.5 5.7 2.3 -2.4
Smoking Status 1.2 2.9 5.6 -2.4 0.4
Allergy or Eczema 1.9 5.1 9.4 0.9 3.1
Cardiovascular Disease 0.1 0.2 0.4 0.6 0.1
Hypothyroidism (self reported) 1.3 2.9 5.7 0.4 2.4
Respiratory disease 0.5 1.0 1.6 -1.3 -0.6
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.5 0.6 0.7
Lung FEV1/FVC ratio 0.1 0.6 0.8 0.9 -0.6
Lung FVC 0.4 2.2 3.8 2.0 0.7
Neuroticism 0.5 1.1 2.0 0.4 -1.4
Chronotype (morning person) 1.1 2.6 4.8 0.5 2.2
Hair Pigment 0.0 0.3 0.6 -0.8 0.2
Tanning 0.1 1.2 1.5 -0.9 1.2
Hand grip strength (left) 0.6 1.7 2.3 1.0 -1.5
Number of treatments/medications taken 0.5 0.8 1.1 -1.0 -0.7
Average weekly spirits intake 0.4 0.5 0.9 -0.1 -1.0
Sensitivity / hurt feelings 1.1 1.9 2.3 1.2 -1.5
Frequency of depressed mood in last 2 weeks 0.5 0.8 1.5 -0.2 -1.2
Hearing difficulty/problems: Yes 0.5 0.7 1.4 -1.2 0.2
Relative age of first facial hair 0.4 0.8 1.6 1.3 0.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.5 0.7 0.3
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.1 -1.0 -0.6
Ever had hysterectomy (womb removed) 0.7 0.8 0.8 0.9 -0.9
Systolic blood pressure, automated reading 1.0 3.0 5.7 0.4 -2.4
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 3.2 1.8 -0.2
Angina 0.2 0.3 0.4 0.4 -0.6
Medication for hormone replacement therapy 0.2 0.2 0.3 -0.4 0.5
Vitamin and mineral supplements 0.6 0.9 1.8 0.0 1.3
Supplements: Zinc 1.3 1.4 1.4 -1.2 -1.2
Medication: Co-codamol 0.3 0.4 0.5 -0.4 0.7
Medication: Metformin 0.1 0.1 0.2 0.4 0.4
Diabetes (father) 0.7 0.9 1.1 -1.1 0.8
Diabetes (mother) 1.4 1.8 1.9 -1.3 -1.4
Severe depression (siblings) 0.3 0.4 0.7 -0.8 0.1
Pack years adult smoking proportion 0.6 0.8 1.3 -1.2 -0.6
Impedance of leg (right) 0.3 1.5 2.2 1.0 -1.5
Leg fat-free mass (left) 0.3 1.6 3.0 -1.7 0.3
Trunk fat percentage 0.4 1.8 3.2 -1.8 0.6
Hand grip strength (right) 0.5 1.3 1.3 1.2 -1.2
Townsend deprivation index at recruitment 1.2 1.7 2.2 -1.1 1.5
Current tobacco smoking 0.9 1.5 2.9 -1.7 0.2
Average weekly fortified wine intake 0.1 0.1 0.2 0.4 0.2
Maternal smoking around birth 0.0 0.0 0.0 0.0 -0.0
Fed-up feelings 0.1 0.2 0.5 -0.7 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.7 0.8 -0.3
Relative age voice broke 0.4 0.5 1.1 1.0 0.2
Taking other prescription medications 0.6 0.9 1.4 -0.7 1.2
Age when periods started (menarche) 0.2 0.5 0.7 0.8 -0.5
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.6 -0.4 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 4.1 9.4 12.2 2.6 3.5
Tinnitus: Yes, but not now, but have in the past 0.1 0.2 0.2 -0.5 -0.3
Qualifications: CSEs or equivalent 0.3 0.3 0.7 -0.8 -0.0
Serious illness, injury or assault to yourself 1.0 1.3 2.5 0.2 -1.6
High blood pressure 0.7 2.0 3.9 2.0 -0.2
Hayfever, allergic rhinitis or eczema 1.3 2.9 5.4 0.6 2.3
Multivitamins +/- minerals 0.9 1.2 2.3 -0.2 -1.5
Stomach or abdominal pain in last month 0.3 0.3 0.6 -0.8 -0.1
Supplements: Glucosamine 0.5 0.6 1.2 1.1 -0.1
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 3.9 2.0 -1.2
Medication: Atenolol 0.1 0.2 0.3 -0.0 -0.6
Medication: Levothyroxine sodium 1.5 2.6 5.2 0.2 2.3
Sitting height 0.1 0.6 0.6 0.8 -0.7
Chronic bronchitis/emphysema (father) 0.3 0.3 0.6 0.2 -0.8
High blood pressure (mother) 3.2 4.5 8.1 0.9 -2.8
Body mass index (BMI) 0.4 1.7 2.0 -1.4 1.2
Impedance of leg (left) 0.3 1.3 2.3 0.6 -1.5
Leg predicted mass (left) 0.3 1.5 2.8 -1.7 0.3
Trunk fat mass 0.4 1.8 3.4 -1.9 0.5
Waist circumference 0.4 1.5 2.9 -1.7 0.1
Number of incorrect matches in round 1.7 2.9 3.5 -1.9 -1.5
Past tobacco smoking 0.3 0.5 1.1 1.0 0.1
Alcohol usually taken with meals 1.9 3.0 5.8 2.4 -0.4
Nervous feelings 0.3 0.6 0.8 0.5 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.9 -0.3 -1.4
Hearing difficulty/problems with background noise 0.4 0.7 0.7 -0.8 -0.9
Hair/balding pattern: Pattern 2 0.3 0.4 0.7 0.3 -0.8
Had menopause 0.5 0.6 0.9 -0.5 1.0
Had other major operations 2.3 2.9 5.5 0.5 -2.3
Forced vital capacity (FVC) 0.2 0.7 1.1 -0.6 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 3.6 8.3 8.7 2.9 2.8
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 2.2 -1.1 1.5
Qualifications: None of the above 0.3 0.7 0.8 -0.9 -0.8
Financial difficulties in last 2 years 0.7 1.0 1.8 -0.3 1.3
Mouth/teeth dental problems 0.5 0.7 1.3 -0.3 -1.1
Heart attack 2.6 3.3 3.6 -1.8 -1.9
Allergy 0.3 0.6 1.1 -0.4 -1.0
Pain all over the body in last month 0.9 1.0 1.7 -1.3 -0.5
Diabetes (self-reported) 0.1 0.2 0.2 0.4 0.4
Hayfever/allergic rhinitis (self-reported) 2.5 3.3 6.1 0.7 2.5
Medication: Ramipril 0.1 0.1 0.3 0.5 0.0
Medication: Simvastatin 0.2 0.3 0.5 -0.7 0.4
Fluid intelligence score 0.3 0.7 1.4 1.2 0.1
Illnesses of siblings 0.8 1.1 2.1 -1.4 0.4
Neuroticism score 0.7 1.5 2.9 0.3 -1.7
Weight 0.3 1.7 3.2 -1.8 0.2
Impedance of arm (right) 0.1 0.3 0.5 -0.7 0.3
Arm fat percentage (right) 0.8 3.3 4.3 -2.1 1.5
Trunk fat-free mass 0.2 0.9 1.0 -1.0 -0.9
Hip circumference 0.9 3.8 7.0 -2.6 0.7
Time employed in main current job 0.2 0.3 0.3 0.5 0.6
Alcohol intake versus 10 years previously 0.0 0.0 0.1 -0.3 0.1
Father’s age at death 0.1 0.1 0.2 -0.2 0.4
Worrier / anxious feelings 1.0 1.9 3.0 1.7 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.6 -0.2 -1.3
Falls in the last year 1.9 2.6 3.6 1.9 1.2
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 0.1 0.8
Number of live births 0.5 0.7 1.0 -1.0 0.6
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 2.9 -0.6 -1.7
Pulse rate 0.7 1.1 2.3 -0.0 -1.5
Happiness 0.1 0.1 0.1 -0.3 -0.3
Noisy workplace 0.9 1.1 1.7 -0.6 1.3
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.5 -0.0 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 0.1 -0.7
Mouth/teeth dental problems: Dentures 1.6 2.7 3.3 -1.5 1.8
Asthma 0.2 0.3 0.5 -0.7 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.4 0.6 0.8 0.5
Medication: Cholesterol lowering 0.0 0.0 0.1 0.3 -0.0
Depression (self-reported) 0.2 0.3 0.5 0.0 0.7
Medication: Lansoprazole 2.0 2.3 3.8 -1.9 0.9
Prospective memory result 1.4 1.7 2.1 1.1 -1.4
Lung cancer (father) 0.7 0.8 1.1 1.1 0.6
Illnesses of mother 2.7 3.4 6.6 -0.3 2.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.7 -0.4 -0.8
Pulse wave Arterial Stiffness index 2.1 2.5 4.8 2.2 0.3
Impedance of arm (left) 0.0 0.0 0.0 -0.0 -0.1
Arm fat mass (right) 0.6 2.5 4.2 -2.1 0.9
Trunk predicted mass 0.2 1.0 1.0 -1.0 -1.0
Standing height 0.3 2.8 4.7 -0.9 -2.2
Length of working week for main job 0.3 0.4 0.4 -0.6 -0.6
Exposure to tobacco smoke at home 2.9 3.2 5.6 -2.4 0.9
Breastfed as a baby 0.3 0.4 0.7 0.9 -0.0
Tense / ‘highly strung’ 2.6 4.4 8.2 -0.7 -2.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.2 0.5 0.5
Hair/balding pattern: Pattern 4 1.7 4.0 5.3 1.7 2.3
Birth weight of first child 1.4 2.6 5.1 2.2 0.4
Peak expiratory flow (PEF) 1.0 2.2 3.1 -1.2 -1.8
Pulse wave reflection index 1.4 1.8 3.5 1.9 0.3
Ever highly irritable/argumentative for 2 days 0.9 1.1 1.2 1.1 0.9
Loud music exposure frequency 0.6 0.6 1.1 0.3 -1.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.2 0.5 0.5
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.4 -0.5 -0.6
Blood clot in the leg (DVT) 0.1 0.1 0.2 -0.5 0.0
Medication: Paracetamol 0.1 0.2 0.4 -0.6 -0.0
Headache pain in last month 0.3 0.5 0.7 -0.5 -0.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 0.7 -0.8 0.8
Glaucoma (self-reported) 0.0 0.0 0.0 0.2 -0.1
Gout (self-reported) 0.7 0.9 1.2 1.1 0.8
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 2.8 -0.6 1.7
Medication: Amlodipine 0.5 0.7 1.2 1.1 -0.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.5 -0.7 0.4
Birth weight 1.9 4.0 8.1 2.8 0.1
Chronic bronchitis/emphysema (mother) 1.3 1.5 3.0 -1.7 0.1
High blood pressure (siblings) 1.1 1.5 2.9 1.7 -0.4
Forced vital capacity (FVC), Best measure 0.1 0.5 0.8 -0.9 -0.4
Body fat percentage 0.5 1.9 3.2 -1.8 0.7
Leg fat percentage (right) 0.4 1.3 1.9 -1.4 0.9
Arm fat-free mass (right) 0.1 0.7 0.8 -0.9 -0.9
Exposure to tobacco smoke outside home 0.2 0.2 0.3 -0.6 0.3
Comparative body size at age 10 1.0 2.9 5.6 -0.4 2.4
Number of full brothers 0.2 0.2 0.3 0.6 -0.4
Worry too long after embarrassment 0.2 0.3 0.4 -0.6 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.9 -0.1 -1.0
Wheeze or whistling in the chest in last year 0.5 0.8 1.4 0.5 -1.2
Number of children fathered 0.2 0.3 0.4 0.6 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 2.5 -1.6 -0.9
Age at first live birth 0.2 0.3 0.4 -0.5 0.6
Pulse wave peak to peak time 2.5 3.0 5.6 -2.4 -0.5
Health satisfaction 1.2 1.6 3.0 -0.4 -1.7
Shortness of breath walking on level ground 0.5 0.6 1.2 0.1 -1.1
Qualifications: College or University degree 0.0 0.1 0.2 0.4 -0.0
Eye problems/disorders: None of the above 0.1 0.2 0.3 -0.2 0.5
Mouth/teeth dental problems: Loose teeth 3.6 4.3 4.7 2.0 2.2
Emphysema/chronic bronchitis 0.1 0.1 0.1 -0.3 0.3
Medication for pain relief, constipation, heartburn 0.3 0.5 0.9 0.9 0.3
Neck or shoulder pain in last month 0.7 1.0 1.8 -1.3 0.4
Medication: Blood pressure 0.9 1.6 2.5 1.6 -0.9
Angina (self-reported) 0.2 0.2 0.4 0.2 -0.6
Migraine (self-reported) 0.0 0.0 0.1 -0.2 -0.2
Medication: Ibuprofen 0.3 0.3 0.6 0.8 0.1
Medication: Allopurinol 1.0 1.3 2.5 0.3 1.6
Medication: Omeprazole 0.2 0.2 0.3 -0.5 -0.5
Medication: Seretide 50 evohaler 2.3 2.6 3.9 1.1 -2.0
Mean time to correctly identify matches 0.1 0.2 0.3 0.5 0.3
Heart disease (mother) 1.7 2.1 3.9 2.0 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.4 -0.3
Whole body fat mass 0.4 1.8 3.3 -1.8 0.6
Leg fat mass (right) 0.4 1.5 2.3 -1.5 0.8
Arm predicted mass (right) 0.1 0.7 0.8 -0.9 -0.8
Pulse rate, automated reading 0.1 0.2 0.4 0.6 -0.2
Alcohol intake frequency. 0.2 0.5 0.8 -0.4 -0.9
Comparative height size at age 10 1.1 6.0 6.8 -2.6 -2.3
Number of full sisters 0.2 0.3 0.6 0.0 0.8
Suffer from ‘nerves’ 0.1 0.1 0.2 0.4 -0.2
Overall health rating 0.7 1.5 2.9 -0.3 -1.7
Chest pain or discomfort 0.4 0.5 0.7 0.8 0.6
Had major operations 0.7 0.8 1.0 -0.8 -1.0
Age at last live birth 1.1 1.6 3.3 -1.8 0.1
Family relationship satisfaction 0.2 0.3 0.6 -0.7 -0.0
Leg pain on walking 0.2 0.2 0.5 0.7 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.1 0.1 0.3
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 -0.1 0.1
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 3.1 -0.7 1.8
Medication: Aspirin 0.0 0.0 0.0 -0.2 -0.2
Supplements: Vitamin C 1.0 1.2 2.1 0.5 -1.5
Knee pain experienced in last month 0.1 0.2 0.4 -0.0 0.7
Hypertension (Self-reported) 0.6 1.6 3.1 1.8 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.4 -0.5 0.6
Illnesses of father: Heart disease 1.6 2.3 4.4 -0.4 -2.1
Illnesses of siblings: Diabetes 2.8 3.5 3.6 -1.9 -1.8
Smoking status: Previous 0.2 0.3 0.6 -0.8 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.4 -0.6 0.3
Whole body fat-free mass 0.2 0.9 1.5 -1.2 -0.6
Leg fat-free mass (right) 0.3 1.7 3.3 -1.8 0.3
Arm fat percentage (left) 0.8 3.0 3.2 -1.8 1.7
Average weekly red wine intake 1.3 1.9 3.8 1.9 -0.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.8 -0.3 -0.9
Mood swings 1.2 2.2 3.1 -1.2 -1.8
Loneliness, isolation 0.3 0.4 0.7 0.8 -0.3
Long-standing illness, disability or infirmity 0.2 0.4 0.7 -0.8 0.3
Ever had bowel cancer screening 2.1 2.5 3.5 1.9 -1.2
Diabetes diagnosed by doctor 0.0 0.1 0.1 0.3 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 2.8 -1.7 -0.6
Friendships satisfaction 0.3 0.4 0.5 -0.5 -0.7
Qualifications: nursing, teaching 0.4 0.6 1.2 -0.1 -1.1
Commuting to job workplace: Walk 0.7 0.7 1.4 -0.2 1.2
Eye problems/disorders: Cataract 0.8 1.0 1.8 -1.4 -0.3
Mouth/teeth dental problems: Mouth ulcers 2.9 4.6 8.5 2.9 0.9
Medication for cholesterol 0.6 0.9 1.8 1.3 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.5 -0.7 -0.5
Back pain experienced in last month 0.1 0.2 0.3 0.6 0.2
Mineral and other dietary supplements 0.5 0.6 1.2 0.1 1.1
Breast cancer (self-reported) 0.1 0.1 0.2 -0.5 -0.1
Asthma (self-reported) 0.2 0.5 0.8 -0.9 -0.4
Osteoporosis (self-reported) 1.3 1.6 1.7 -1.3 -1.2
Osteoarthritis (self-reported) 2.3 3.0 5.2 -2.3 1.0
Medication: Aspirin 0.1 0.2 0.2 -0.4 -0.4
Medication: Gliclazide 1.0 1.1 1.2 1.0 1.1
Illnesses of father: None of the above (group 1) 0.5 0.6 1.3 0.1 -1.1
Smoking status: Current 0.6 1.0 2.0 -1.4 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 0.8 0.6 -0.9
Whole body water mass 0.2 1.1 1.8 -1.3 -0.6
Leg predicted mass (right) 0.3 1.8 3.4 -1.8 0.4
Arm fat mass (left) 0.5 2.2 3.4 -1.8 1.0
Number of self-reported non-cancer illnesses 0.4 0.6 1.0 -0.5 -1.0
Average weekly champagne plus white wine intake 0.4 0.5 0.6 0.8 -0.6
Miserableness 0.1 0.2 0.3 -0.6 -0.4
Guilty feelings 0.1 0.1 0.1 -0.3 -0.3
Wears glasses or contact lenses 1.4 1.6 2.0 1.1 -1.4
Ever taken oral contraceptive pill 0.6 0.7 1.0 1.0 -0.5
Hearing aid user 0.0 0.0 0.1 -0.1 -0.2
Mother’s age at death 0.4 0.5 0.9 -0.3 -0.9
Financial situation satisfaction 4.1 5.1 9.5 -3.1 0.9
Tinnitus: Yes, now most or all of the time 1.8 2.0 3.1 -1.8 -1.0
Commuting to job workplace: Public transport 0.2 0.2 0.3 0.6 -0.2
Eye problems/disorders: Glaucoma 0.3 0.3 0.4 -0.5 -0.6
Medication: Blood pressure 0.5 1.0 1.7 -1.3 -0.5
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.4 -0.3
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.3 -0.3 -1.1
High cholesterol (Self-reported) 0.2 0.3 0.5 -0.4 -0.7
Medication: Bendroflumethiazide 0.2 0.3 0.6 -0.8 -0.1
Medication: Paracetamol 0.0 0.0 0.1 -0.2 0.2
Medication: Lisinopril 0.0 0.0 0.0 0.0 0.1
Medication: Atorvastatin 0.0 0.1 0.1 -0.3 -0.1
Illnesses of father: High blood pressure 0.4 0.6 0.7 0.7 0.8
Alcohol drinker status: Never 0.5 0.6 0.7 0.8 -0.8
Ever smoked 0.7 1.3 2.2 -1.5 -0.5
Basal metabolic rate 0.2 1.2 2.3 -1.5 -0.4
Leg fat percentage (left) 0.4 1.5 2.3 -1.5 0.9
Arm fat-free mass (left) 0.3 1.7 2.2 -1.5 -1.0
Number of operations (self-reported) 3.7 5.5 9.8 1.1 -3.1
Average weekly beer plus cider intake 0.3 0.5 0.9 -0.9 0.3
Irritability 0.0 0.1 0.1 -0.2 0.2
Risk taking 0.2 0.3 0.5 0.7 -0.2
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.9 -0.9 -0.4
Fractured/broken bones in last 5 years 1.0 1.3 1.8 -0.9 -1.3
Age started oral contraceptive pill 0.5 0.6 0.9 0.9 -0.6
Diastolic blood pressure, automated reading 1.0 3.1 4.3 1.4 -2.1
Ever depressed for a whole week 0.5 0.6 0.9 -0.6 0.9
Unable to work because of sickness or disability 0.3 0.4 0.7 -0.8 -0.2
Commuting to job workplace: Cycle 2.0 2.4 2.6 -1.6 1.5
Myopia 0.6 0.9 1.7 1.3 0.4
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.1 -1.4 0.4
Cholesterol lowering medication 1.0 1.5 2.9 -1.7 0.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 -0.6 -0.2
Pain experienced in last month 0.5 0.8 1.4 1.2 -0.4
Supplements: Calcium 1.0 1.1 1.5 -0.8 -1.2
Basal cell carcinoma (self-reported) 1.6 2.0 2.6 -1.2 -1.6
Heart attack/myocardial infarction (self-reported) 1.9 2.4 2.5 -1.6 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.4 -0.6 -0.0
Heart disease (siblings) 0.2 0.2 0.4 0.7 -0.1
Alcohol drinker status: Previous 0.1 0.1 0.1 0.2 -0.3
Pack years of smoking 0.8 1.2 2.1 -1.4 -0.6
Impedance of whole body 0.1 0.6 0.7 0.7 -0.8
Leg fat mass (left) 0.5 1.9 3.0 -1.7 0.9
Arm predicted mass (left) 0.3 1.3 1.5 -1.2 -1.0