Hub : Genes

NIM1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.114	0.059	0.00160	0.002	NA	0.017	NA	0.003	0.210	NA	0.0160	NA	0.1700
2	GTEx	Skin Sun Exposed Lower leg	0.088	0.034	0.00051	0.009	NA	0.024	NA	0.028	0.059	NA	0.0038	NA	0.0022
3	GTEx	Thyroid	0.062	0.029	0.00420	0.010	NA	0.020	NA	0.014	0.054	NA	0.0110	NA	0.0260

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.4	0.6	-0.1	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.7	1.2	1.0	0.1	-1.1
Depressed Affect (Nagel 2018)	0.5	1.1	1.5	-1.2	0.9	1.1
Depression (Nagel 2018)	0.9	1.4	2.2	-1.4	1.5	-0.4
Intelligence (Savage-Jansen 2018)	0.7	2.2	3.2	-0.6	-1.7	-1.8
Neuroticism (Nagel 2018)	0.4	0.9	2.2	-1.5	-0.4	0.4
Schizophrenia (2018)	0.2	0.5	1.2	0.5	0.2	-1.1
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.4	-0.7	-0.3
Worry (Nagel 2018)	0.4	0.9	2.3	-0.7	-1.5	0.0
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	0.2	-0.5	1.2
Alzheimer’s Disease (in father)	0.5	0.6	0.8	0.6	0.8	0.9
Alzheimer’s Disease (including proxy)	0.7	1.0	2.4	0.6	-0.5	1.6
Crohns Disease (2017)	0.2	0.5	1.3	-1.2	-0.1	-0.5
Irritable Bowel Disease (IBD)	0.6	1.5	2.4	-1.0	-1.1	-1.6
Ulcerative Colitis (UC)	1.6	3.0	4.9	-0.8	-1.8	-2.2
Major Depression (MDD)	1.8	2.2	3.6	-1.9	-0.6	-1.7
Reaction Time	0.6	1.1	2.6	-1.6	0.4	-0.8
Verbal and Numeric Reasoning (VNR)	2.2	5.4	8.8	-0.5	-2.6	-3.0
Breast Cancer	1.3	3.2	4.7	-2.2	2.1	0.4
Ovarian Cancer	0.8	1.0	2.9	-1.7	-0.0	0.4
Prostate Cancer	1.6	2.2	6.5	-0.1	-0.3	2.5
Age at First Birth	1.0	1.5	4.0	2.0	0.2	0.6
Bipolar Disorder (2011)	2.0	1.9	5.6	-0.1	-0.4	-2.4
Body Mass Index (BMI) (2010)	2.7	3.7	6.6	-0.6	-2.6	-2.1
Coronary Artery Disease (CAD)	0.4	0.5	1.5	0.1	-1.2	-0.1
Crohns Disease (2012)	0.0	0.0	0.1	-0.3	0.0	-0.2
Mean Putamen Volume	0.3	0.3	0.5	-0.3	0.6	-0.7
Fasting Glucose	0.2	0.2	0.6	0.1	-0.2	0.8
HbA1C	0.6	0.7	1.0	-1.0	-0.0	1.0
HDL Cholesterol	1.0	1.6	4.5	2.1	-0.6	-0.3
LDL Cholesterol	0.6	0.9	1.7	0.7	1.3	0.6
Lupus	0.1	0.2	0.5	-0.1	-0.7	-0.0
Neuroticism (2016)	0.4	0.5	1.2	-1.1	0.6	0.3
Primary Biliary Cirrhosis	1.0	1.4	3.3	1.8	0.0	0.9
Rheumatoid Arthritis	0.1	0.2	0.4	0.3	0.7	0.2
Schizophrenia (2014)	0.3	0.6	1.4	1.2	0.6	-0.4
Triglycerides	0.4	0.6	1.0	-1.0	0.8	0.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.3	-0.6	-1.5	0.3
Ulcerative Colitis	2.7	3.9	8.3	-0.8	-1.6	-2.9
Blood Eosinophil Count	0.2	1.9	3.3	-1.0	-1.2	-1.8
Blood Platelet Count	0.0	0.0	0.1	-0.2	0.2	-0.1
Blood Red Count	0.3	2.9	5.5	-2.3	1.8	0.4
Blood White Count	0.2	1.1	3.3	-0.3	1.8	0.0
Heel T-Score	0.4	3.5	7.1	1.8	2.7	0.4
BMI	2.0	11.5	22.1	-3.5	-0.1	-4.7
Height	0.7	12.6	34.3	-1.7	-5.9	-0.7
Waist Hip Ratio (WHR)	1.0	4.4	9.7	-1.6	0.9	3.1
Systolic Blood Pressure	0.6	2.9	4.7	-2.2	-2.0	-0.3
Smoking Status	2.1	4.9	10.1	-3.2	2.2	0.1
Allergy or Eczema	0.3	0.7	1.9	1.4	0.5	0.1
Cardiovascular Disease	0.2	0.8	1.8	-1.3	-0.7	-0.1
Hypothyroidism (self reported)	0.4	1.0	2.7	-0.5	0.3	-1.6
Respiratory disease	0.1	0.2	0.4	0.5	-0.2	-0.6
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.9	-1.5	-0.4	-2.0
Lung FEV1/FVC ratio	0.6	3.2	5.5	-2.4	2.0	0.4
Lung FVC	0.1	0.4	1.0	-0.4	0.3	1.0
Neuroticism	0.2	0.5	1.5	-1.2	-0.2	-0.0
Chronotype (morning person)	1.8	4.1	8.3	-0.0	2.0	2.9
Hair Pigment	0.0	1.2	2.9	0.7	1.7	0.5
Tanning	0.3	3.3	6.9	2.6	0.1	1.7
Hand grip strength (left)	0.5	1.3	3.3	-1.8	-0.7	0.5
Number of treatments/medications taken	0.2	0.4	0.7	-0.4	-0.6	-0.8
Average weekly spirits intake	0.5	0.6	1.8	-1.3	0.0	-0.0
Sensitivity / hurt feelings	0.5	0.8	2.0	-1.4	-0.5	0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	-0.8	-0.4	-0.6
Hearing difficulty/problems: Yes	1.8	2.8	5.1	0.8	1.7	2.3
Relative age of first facial hair	0.4	0.8	1.9	0.7	-1.4	0.3
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.0	0.7	-1.4	-1.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	0.8	0.0	-0.5
Ever had hysterectomy (womb removed)	0.7	0.8	2.1	0.3	-0.5	-1.4
Systolic blood pressure, automated reading	0.2	0.6	1.1	-1.0	-0.4	-0.6
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	3.5	0.2	-1.9	-1.0
Angina	0.3	0.4	0.8	-0.9	-0.3	-0.4
Medication for hormone replacement therapy	0.6	0.7	1.1	0.6	-1.0	-0.8
Vitamin and mineral supplements	0.2	0.3	0.6	-0.8	-0.6	-0.1
Supplements: Zinc	0.9	1.0	1.8	-1.0	-1.3	-0.3
Medication: Co-codamol	0.8	0.9	1.7	-0.9	-0.5	-1.3
Medication: Metformin	1.1	1.6	2.7	-1.6	-0.8	-1.2
Diabetes (father)	2.5	3.1	4.5	0.8	2.1	2.1
Diabetes (mother)	2.3	2.9	8.1	-2.8	0.6	0.4
Severe depression (siblings)	2.4	2.7	6.8	0.2	-2.6	-1.1
Pack years adult smoking proportion	0.6	0.9	2.4	-1.5	-0.0	-0.4
Impedance of leg (right)	1.7	8.3	17.1	2.0	2.0	4.1
Leg fat-free mass (left)	2.5	13.3	15.3	-3.2	-3.7	-3.9
Trunk fat percentage	2.3	9.3	15.9	-4.0	-0.8	-3.4
Hand grip strength (right)	0.2	0.6	1.5	-1.2	-0.4	-0.0
Townsend deprivation index at recruitment	0.4	0.6	1.6	-0.1	-1.3	-0.2
Current tobacco smoking	2.4	3.9	7.5	-2.7	2.0	0.1
Average weekly fortified wine intake	1.9	2.3	5.4	2.3	-0.3	1.1
Maternal smoking around birth	0.8	1.1	1.7	-1.3	-0.8	-1.0
Fed-up feelings	0.3	0.6	1.8	-1.3	-0.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.7	-0.0	1.6	0.1
Relative age voice broke	0.3	0.5	0.7	0.5	-0.8	-0.8
Taking other prescription medications	1.1	1.7	2.4	-1.4	0.8	-1.6
Age when periods started (menarche)	3.1	7.3	18.1	4.2	0.2	2.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.5	-0.7	-0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	0.6	0.5	0.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	0.9	-1.0	-0.9	-0.9
Qualifications: CSEs or equivalent	1.0	1.3	3.3	-1.8	-0.2	0.7
Serious illness, injury or assault to yourself	0.3	0.4	0.5	-0.5	-0.7	0.6
High blood pressure	1.3	3.5	3.8	-1.9	-1.9	-1.8
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.7	1.3	0.7	0.4
Multivitamins +/- minerals	0.3	0.4	0.9	0.5	-0.3	-0.9
Stomach or abdominal pain in last month	2.5	3.1	5.5	-2.3	-1.1	-1.6
Supplements: Glucosamine	1.7	2.2	5.8	2.4	0.5	0.7
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.6	-0.8	-1.9	-1.3
Medication: Atenolol	0.3	0.4	1.3	-1.1	0.2	0.0
Medication: Levothyroxine sodium	0.6	1.0	1.5	-0.8	1.2	-0.9
Sitting height	0.7	5.0	12.8	-1.1	-3.6	-1.0
Chronic bronchitis/emphysema (father)	1.7	2.0	3.4	-1.8	0.2	-1.6
High blood pressure (mother)	0.2	0.3	0.8	-0.9	0.1	0.5
Body mass index (BMI)	2.8	11.9	22.8	-3.5	-0.9	-4.8
Impedance of leg (left)	2.1	10.4	21.0	1.8	2.6	4.6
Leg predicted mass (left)	2.6	13.6	15.6	-3.2	-3.9	-4.0
Trunk fat mass	3.1	13.2	20.2	-4.5	-1.7	-4.1
Waist circumference	2.4	8.7	12.3	-3.5	-1.4	-3.5
Number of incorrect matches in round	0.5	0.8	1.3	-1.1	0.9	-0.6
Past tobacco smoking	0.7	1.2	1.9	1.4	-1.2	-0.4
Alcohol usually taken with meals	1.0	1.6	3.7	1.0	0.1	1.9
Nervous feelings	1.0	1.8	3.8	-0.1	-1.9	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.8	-1.0	1.3	0.1
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.0	1.0	0.3
Hair/balding pattern: Pattern 2	1.0	1.2	2.8	0.8	-0.5	-1.7
Had menopause	0.4	0.5	1.2	1.1	-0.2	-0.5
Had other major operations	0.3	0.3	0.7	-0.3	-0.4	0.8
Forced vital capacity (FVC)	0.3	1.0	2.8	-0.4	-1.7	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.5	0.6	-0.7	-0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	0.9	0.0	-0.5
Qualifications: None of the above	0.6	1.4	3.5	0.2	1.9	0.7
Financial difficulties in last 2 years	0.5	0.6	1.4	-1.2	-0.5	0.5
Mouth/teeth dental problems	5.8	8.9	15.8	4.0	-2.9	-1.6
Heart attack	1.6	2.0	6.0	2.4	0.2	0.3
Allergy	0.2	0.4	0.9	-0.9	-0.5	0.0
Pain all over the body in last month	0.4	0.4	1.0	0.2	0.6	1.0
Diabetes (self-reported)	0.6	0.9	2.5	-0.3	0.1	-1.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.3	1.1	0.2	-0.3
Medication: Ramipril	2.3	3.0	7.4	0.8	-2.7	-0.9
Medication: Simvastatin	0.7	1.1	3.2	-0.2	-1.8	0.1
Fluid intelligence score	2.6	5.4	8.1	-2.0	-2.0	-2.9
Illnesses of siblings	1.1	1.5	2.4	-0.6	1.5	1.4
Neuroticism score	0.2	0.4	0.9	-0.9	-0.3	0.6
Weight	3.1	15.3	20.8	-4.2	-2.8	-4.6
Impedance of arm (right)	1.3	5.9	13.6	1.3	1.5	3.7
Arm fat percentage (right)	2.4	9.5	14.3	-3.7	-0.1	-3.8
Trunk fat-free mass	1.9	11.0	17.3	-2.4	-4.2	-3.1
Hip circumference	3.2	13.8	22.9	-2.9	-3.2	-4.8
Time employed in main current job	2.2	2.6	4.0	-2.0	-1.0	-1.6
Alcohol intake versus 10 years previously	0.5	0.7	1.2	-1.1	0.7	-0.8
Father’s age at death	0.6	0.8	1.3	1.1	1.1	0.0
Worrier / anxious feelings	1.4	2.6	6.0	-2.5	-0.5	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.4	-1.8	0.2	-0.4
Falls in the last year	0.1	0.1	0.4	-0.0	-0.2	0.6
Hair/balding pattern: Pattern 3	0.8	1.2	3.4	-1.8	0.5	0.3
Number of live births	1.0	1.4	2.2	1.5	1.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.3	-0.6	-0.4	0.6
Pulse rate	0.1	0.2	0.6	-0.3	0.8	0.1
Happiness	1.3	1.6	4.6	2.2	0.4	-0.0
Noisy workplace	1.5	1.8	3.6	0.9	1.0	1.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.5	-0.2	-1.2	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.3	-0.1	0.4
Mouth/teeth dental problems: Dentures	1.8	3.1	6.7	-2.6	1.6	0.1
Asthma	0.3	0.6	1.5	0.4	-0.0	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	-1.1	0.4	0.5
Medication: Cholesterol lowering	1.0	1.6	2.9	0.2	-1.7	-1.3
Depression (self-reported)	1.0	1.1	1.6	-1.1	-1.2	-0.8
Medication: Lansoprazole	0.2	0.2	0.4	0.5	-0.6	0.2
Prospective memory result	0.9	1.1	2.5	-0.7	-1.6	-0.6
Lung cancer (father)	0.9	1.1	1.6	0.7	1.0	1.3
Illnesses of mother	0.7	0.9	2.3	1.5	-0.4	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	-0.7	-0.3	0.4
Pulse wave Arterial Stiffness index	0.5	0.6	1.6	0.5	-0.1	-1.3
Impedance of arm (left)	0.9	4.1	10.0	1.0	1.1	3.2
Arm fat mass (right)	2.9	11.8	18.1	-4.0	-1.3	-4.3
Trunk predicted mass	2.0	11.2	17.4	-2.4	-4.2	-3.2
Standing height	0.8	7.7	17.9	-2.2	-4.2	-0.2
Length of working week for main job	0.5	0.6	0.8	-0.9	0.8	-0.5
Exposure to tobacco smoke at home	0.7	0.8	1.7	0.1	-1.3	0.8
Breastfed as a baby	1.1	1.3	1.9	1.4	-0.6	-1.3
Tense / ‘highly strung’	0.6	1.0	2.3	-1.5	-0.7	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.8	-0.0	-0.4
Hair/balding pattern: Pattern 4	0.2	0.6	1.7	-0.0	0.0	-1.3
Birth weight of first child	0.2	0.4	0.9	-0.4	0.9	-0.1
Peak expiratory flow (PEF)	0.6	1.5	3.0	-1.7	0.8	0.9
Pulse wave reflection index	1.2	1.4	3.9	0.6	0.1	-2.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.7	0.4	0.1	-1.3
Loud music exposure frequency	0.2	0.2	0.4	0.1	-0.3	0.6
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	5.3	-0.0	-1.4	2.3
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	6.0	-2.5	0.5	1.1
Blood clot in the leg (DVT)	0.9	1.2	2.5	-0.2	1.6	1.1
Medication: Paracetamol	0.1	0.2	0.6	-0.2	-0.8	0.0
Headache pain in last month	0.9	1.5	2.4	-0.9	1.5	1.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	2.1	1.2	1.5	0.9
Glaucoma (self-reported)	0.8	0.9	1.3	-1.1	-0.6	-1.1
Gout (self-reported)	1.8	2.4	3.9	0.6	-1.7	-2.0
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.0	-0.2	0.2	-1.7
Medication: Amlodipine	2.3	3.2	5.2	-2.3	1.8	0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	0.5	-0.8	-0.7
Birth weight	0.7	1.4	2.4	0.5	1.3	1.6
Chronic bronchitis/emphysema (mother)	1.1	1.2	3.3	1.8	-0.3	0.6
High blood pressure (siblings)	5.4	7.7	15.7	-1.2	-4.0	-2.5
Forced vital capacity (FVC), Best measure	0.2	0.9	2.1	-0.6	-1.5	-0.3
Body fat percentage	2.2	8.8	14.5	-3.8	-0.2	-3.4
Leg fat percentage (right)	1.9	6.9	12.9	-2.7	0.6	-3.6
Arm fat-free mass (right)	2.0	10.0	11.6	-2.8	-3.4	-3.3
Exposure to tobacco smoke outside home	3.1	4.1	8.9	-0.3	1.8	3.0
Comparative body size at age 10	0.8	2.3	5.0	0.3	-1.3	-2.2
Number of full brothers	2.7	3.4	5.8	2.4	1.1	1.8
Worry too long after embarrassment	0.1	0.2	0.4	-0.6	-0.5	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.2	-0.6	-0.7
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	-0.6	0.8	-0.3
Number of children fathered	1.1	1.2	1.7	1.0	1.0	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	-0.3	-0.8	-0.6
Age at first live birth	0.5	0.9	1.2	1.0	-1.1	-0.8
Pulse wave peak to peak time	0.5	0.6	1.5	-0.5	-0.3	1.2
Health satisfaction	1.2	1.6	3.6	1.0	-1.9	0.2
Shortness of breath walking on level ground	0.5	0.5	1.3	0.2	-1.1	-0.5
Qualifications: College or University degree	0.6	1.8	3.1	1.3	-1.8	-0.7
Eye problems/disorders: None of the above	0.2	0.3	0.5	0.7	-0.5	-0.1
Mouth/teeth dental problems: Loose teeth	5.8	6.9	17.6	-4.2	0.3	-1.7
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.4	0.2	-0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.4	1.2	-0.2	-0.3
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.3	0.3	0.5
Medication: Blood pressure	1.3	2.3	4.2	-2.0	-1.3	-1.0
Angina (self-reported)	0.1	0.2	0.4	-0.6	-0.0	-0.3
Migraine (self-reported)	1.5	1.8	3.0	-1.7	1.4	0.6
Medication: Ibuprofen	0.6	0.7	1.5	-1.2	0.3	0.8
Medication: Allopurinol	0.8	1.0	2.0	0.5	-0.9	-1.4
Medication: Omeprazole	1.5	1.8	4.9	-2.2	-0.5	0.5
Medication: Seretide 50 evohaler	1.0	1.1	1.9	-1.1	-0.4	-1.4
Mean time to correctly identify matches	0.9	1.8	3.2	-1.4	0.1	-1.8
Heart disease (mother)	1.4	1.7	3.9	-0.4	-0.9	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	0.1	1.2	0.8
Whole body fat mass	3.1	12.7	19.6	-4.4	-1.5	-4.0
Leg fat mass (right)	2.7	10.6	18.0	-3.6	-0.8	-4.2
Arm predicted mass (right)	1.8	9.1	9.4	-3.0	-3.1	-3.0
Pulse rate, automated reading	0.6	1.9	4.8	-1.0	2.2	-0.1
Alcohol intake frequency.	0.2	0.5	1.3	1.1	0.2	0.2
Comparative height size at age 10	1.7	9.2	20.8	-4.6	-2.4	-1.1
Number of full sisters	1.3	1.6	2.8	0.5	-1.7	-1.4
Suffer from ‘nerves’	0.9	1.4	2.2	1.4	-1.5	-0.2
Overall health rating	1.0	2.1	2.8	-1.7	-1.5	-1.2
Chest pain or discomfort	1.3	1.9	3.0	-1.7	-1.4	-0.9
Had major operations	0.1	0.1	0.3	0.3	-0.6	0.1
Age at last live birth	0.6	0.8	2.0	1.4	-0.6	0.1
Family relationship satisfaction	0.3	0.4	0.7	0.4	-0.8	-0.6
Leg pain on walking	0.0	0.0	0.0	-0.1	0.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	1.0	0.4	0.1
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.3	-1.8	0.4	0.2
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.3	-0.5	-1.1	-1.2
Medication: Aspirin	0.2	0.2	0.4	-0.4	0.7	0.1
Supplements: Vitamin C	1.2	1.5	3.2	-1.8	0.5	1.0
Knee pain experienced in last month	1.0	1.6	4.8	-2.2	-0.1	0.1
Hypertension (Self-reported)	1.2	3.4	3.8	-1.9	-1.7	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	4.9	-2.2	-0.2	-0.8
Illnesses of father: Heart disease	1.5	2.0	4.8	-0.3	-1.1	-2.2
Illnesses of siblings: Diabetes	0.4	0.4	1.1	1.1	0.3	0.4
Smoking status: Previous	0.0	0.0	0.1	0.1	0.3	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.6	0.3	-1.6	1.1
Whole body fat-free mass	2.1	12.1	16.0	-2.8	-4.0	-3.5
Leg fat-free mass (right)	2.2	11.8	13.0	-3.2	-3.5	-3.6
Arm fat percentage (left)	2.5	10.1	16.0	-3.8	-0.3	-4.0
Average weekly red wine intake	0.5	0.7	1.9	-0.3	-1.4	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.4	-0.0	0.5
Mood swings	0.3	0.6	1.5	-0.5	-0.3	1.2
Loneliness, isolation	0.5	0.7	1.1	-0.2	1.1	0.9
Long-standing illness, disability or infirmity	0.5	0.8	1.5	0.1	-0.9	-1.2
Ever had bowel cancer screening	0.1	0.1	0.1	-0.1	-0.4	-0.2
Diabetes diagnosed by doctor	0.5	0.8	2.1	0.3	0.3	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.0	0.3	-0.0	1.4
Friendships satisfaction	0.5	0.7	1.1	0.7	-1.1	-0.6
Qualifications: nursing, teaching	0.4	0.7	2.0	-0.2	-1.4	0.1
Commuting to job workplace: Walk	1.7	1.8	2.7	-1.2	1.2	1.6
Eye problems/disorders: Cataract	0.7	0.8	1.2	0.7	1.1	0.9
Mouth/teeth dental problems: Mouth ulcers	2.9	4.7	7.2	-0.8	2.5	2.7
Medication for cholesterol	0.2	0.3	0.8	-0.0	0.9	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.8	-0.1	0.9	1.3
Back pain experienced in last month	0.9	1.3	2.4	-0.7	-1.0	-1.5
Mineral and other dietary supplements	0.4	0.6	1.6	-1.2	-0.5	-0.0
Breast cancer (self-reported)	1.6	1.9	3.9	2.0	-0.0	1.3
Asthma (self-reported)	0.2	0.3	1.0	0.0	-0.0	-1.0
Osteoporosis (self-reported)	0.1	0.2	0.3	-0.3	-0.3	0.6
Osteoarthritis (self-reported)	0.3	0.4	0.9	-1.0	-0.6	-0.1
Medication: Aspirin	0.1	0.1	0.4	0.2	0.6	-0.1
Medication: Gliclazide	1.0	1.1	3.3	-1.8	-0.2	0.0
Illnesses of father: None of the above (group 1)	0.5	0.6	1.0	-1.0	0.0	1.0
Smoking status: Current	2.8	4.5	8.7	-3.0	2.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.5	0.7	0.7	0.2
Whole body water mass	2.2	12.5	16.1	-2.9	-4.0	-3.6
Leg predicted mass (right)	2.2	11.5	12.4	-3.2	-3.4	-3.5
Arm fat mass (left)	2.9	12.0	19.5	-3.9	-1.1	-4.4
Number of self-reported non-cancer illnesses	1.0	1.7	3.1	-1.8	-1.1	-0.9
Average weekly champagne plus white wine intake	0.2	0.2	0.6	0.3	-0.8	0.0
Miserableness	0.3	0.5	1.1	-1.0	-0.6	0.4
Guilty feelings	0.3	0.4	0.7	-0.5	-0.8	-0.7
Wears glasses or contact lenses	0.1	0.1	0.1	0.4	0.3	0.4
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.6	0.3	-0.1
Hearing aid user	1.2	1.3	2.4	-1.1	0.5	1.6
Mother’s age at death	0.3	0.4	0.7	0.1	0.8	-0.6
Financial situation satisfaction	0.1	0.1	0.4	-0.6	0.1	-0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.4	0.4	-0.3
Commuting to job workplace: Public transport	1.5	1.8	3.5	-0.7	-1.9	-1.2
Eye problems/disorders: Glaucoma	0.4	0.4	0.5	-0.7	-0.6	-0.6
Medication: Blood pressure	0.0	0.1	0.1	-0.3	-0.1	0.4
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.6	0.4	-1.6	-0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	1.0	0.4	0.6
High cholesterol (Self-reported)	0.7	1.2	2.7	1.6	-0.3	0.9
Medication: Bendroflumethiazide	0.3	0.5	0.6	-0.7	0.7	0.8
Medication: Paracetamol	0.0	0.1	0.2	-0.0	-0.1	0.4
Medication: Lisinopril	0.8	1.0	2.2	-0.6	-1.5	-0.5
Medication: Atorvastatin	0.6	0.7	1.4	0.5	1.2	-0.7
Illnesses of father: High blood pressure	2.4	3.0	8.8	-0.2	-3.0	-0.4
Alcohol drinker status: Never	0.8	1.0	1.2	1.0	-0.8	-1.1
Ever smoked	0.8	1.5	2.6	-0.9	1.6	1.0
Basal metabolic rate	2.4	13.2	14.7	-3.4	-3.7	-3.8
Leg fat percentage (left)	1.9	7.0	12.0	-2.9	0.9	-3.5
Arm fat-free mass (left)	2.1	10.9	13.5	-2.8	-3.4	-3.7
Number of operations (self-reported)	0.3	0.4	1.3	0.1	0.1	1.1
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.4	-0.5	-0.8
Irritability	0.5	0.8	2.0	-0.6	-0.2	1.4
Risk taking	2.1	3.0	4.8	0.5	2.0	2.2
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.7	-1.9	-0.6	0.4
Fractured/broken bones in last 5 years	1.4	1.8	4.6	-0.5	-2.2	-0.6
Age started oral contraceptive pill	1.3	1.6	2.9	1.7	-1.1	-0.9
Diastolic blood pressure, automated reading	0.7	2.1	4.0	-2.0	-1.0	-1.1
Ever depressed for a whole week	0.4	0.4	0.6	0.8	-0.7	-0.4
Unable to work because of sickness or disability	1.1	1.4	2.5	-1.3	-0.0	1.6
Commuting to job workplace: Cycle	0.4	0.5	1.0	0.3	-1.0	-0.7
Myopia	1.3	2.0	2.9	0.6	-1.6	-1.7
Vascular/heart problems diagnosed by doctor	0.6	1.5	2.1	1.4	1.5	0.7
Cholesterol lowering medication	0.6	0.8	1.1	1.0	0.7	1.0
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	4.1	-2.0	-0.5	0.8
Pain experienced in last month	0.2	0.3	0.9	-0.0	-0.3	-1.0
Supplements: Calcium	0.9	1.0	1.5	1.2	-1.2	0.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	-0.1	0.7	0.4
Heart attack/myocardial infarction (self-reported)	1.5	2.0	5.5	2.4	0.4	0.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.8	-0.3	1.7	0.9
Heart disease (siblings)	0.2	0.2	0.3	0.6	0.3	0.5
Alcohol drinker status: Previous	0.3	0.3	0.7	-0.3	-0.2	0.9
Pack years of smoking	0.6	0.9	1.9	-1.4	-0.4	-0.8
Impedance of whole body	1.6	7.9	17.5	1.5	2.0	4.2
Leg fat mass (left)	2.7	10.7	17.9	-3.7	-0.8	-4.2
Arm predicted mass (left)	1.9	9.8	11.5	-2.9	-3.1	-3.4