Hub : Genes

NMD3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1100 0.0300 0.0e+00 0.132 0.155 0.154 0.148 0.151 8.5e-16 1.9e-18 2.3e-18 1.2e-17 6.4e-18
2 GTEx Cells Transformed fibroblasts 0.0850 0.0490 4.6e-03 0.017 NA -0.003 NA 0.003 1.8e-02 NA 6.3e-01 NA 1.7e-01
3 GTEx Pancreas 0.0880 0.0450 5.5e-03 0.106 NA 0.055 NA 0.086 3.3e-05 NA 2.3e-03 NA 1.7e-04
4 GTEx Skin Sun Exposed Lower leg 0.0970 0.0390 1.6e-03 0.017 NA 0.010 NA 0.013 1.4e-02 NA 4.7e-02 NA 2.5e-02
5 METSIM Adipose 0.0254 0.0141 2.3e-03 0.026 0.014 0.021 0.014 0.028 6.8e-05 3.3e-03 3.7e-04 3.1e-03 4.0e-05
6 TCGA Thyroid Carcinoma 0.0810 0.0390 2.6e-07 0.082 0.081 0.085 NA 0.079 2.0e-08 2.6e-08 1.3e-08 NA 4.1e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.3 0.5 -0.7 -0.4 -0.7 0.3 0.5 0.3
Bipolar Disorder or Schizophrenia 0.6 1.6 3.3 0.4 1.1 0.8 -1.3 -1.6 -1.8
Depressed Affect (Nagel 2018) 0.1 0.3 0.7 -0.4 0.4 -0.4 0.8 -0.5 -0.2
Depression (Nagel 2018) 0.0 0.0 0.1 0.1 -0.0 -0.1 0.1 -0.3 0.1
Intelligence (Savage-Jansen 2018) 0.1 0.5 1.6 -0.6 -1.3 -0.6 0.4 -0.1 0.5
Neuroticism (Nagel 2018) 0.2 0.6 1.4 -1.0 0.7 -0.7 0.1 -1.2 -0.0
Schizophrenia (2018) 1.9 3.9 6.9 1.0 1.7 1.6 -1.9 -2.6 -2.6
Schizophrenia vs Biploar Disorder 3.8 5.0 7.3 1.6 2.1 2.2 -2.0 -2.6 -2.7
Worry (Nagel 2018) 2.1 4.5 7.3 -2.7 -1.3 -2.7 2.0 0.8 2.5
Alzheimer’s Disease (in mother) 1.6 1.9 2.7 -0.7 -1.6 -1.4 1.5 1.6 1.1
Alzheimer’s Disease (in father) 1.7 1.8 3.0 -0.7 -1.6 -1.1 1.7 1.7 1.0
Alzheimer’s Disease (including proxy) 1.3 1.9 3.9 -0.6 -2.0 -1.3 1.7 1.4 0.9
Crohns Disease (2017) 0.7 1.5 2.9 0.9 1.2 1.3 -0.9 -1.3 -1.7
Irritable Bowel Disease (IBD) 0.1 0.3 0.7 0.5 0.3 0.6 0.5 0.2 -0.8
Ulcerative Colitis (UC) 0.6 1.1 2.9 -0.2 -0.9 -0.4 1.7 1.7 0.3
Major Depression (MDD) 0.0 0.0 0.2 0.0 -0.0 0.4 0.2 -0.1 -0.1
Reaction Time 0.4 0.8 1.7 1.0 0.6 0.9 -0.7 -0.5 -1.3
Verbal and Numeric Reasoning (VNR) 1.4 3.4 6.4 -1.8 -2.5 -1.9 1.7 1.2 1.7
Breast Cancer 0.5 1.2 1.8 1.1 0.9 1.0 -1.2 -0.9 -1.3
Ovarian Cancer 1.4 1.8 4.5 0.1 1.0 1.0 -1.6 -2.1 -1.4
Prostate Cancer 0.6 0.9 2.2 0.7 1.5 0.8 -0.7 0.3 -1.2
Age at First Birth 0.1 0.2 0.6 0.1 0.2 0.2 -0.6 -0.8 -0.1
Bipolar Disorder (2011) 4.1 3.9 5.5 1.7 1.4 2.0 -2.0 -2.3 -2.3
Body Mass Index (BMI) (2010) 2.0 2.8 5.0 2.2 1.5 2.1 -1.4 -0.4 -1.7
Coronary Artery Disease (CAD) 3.8 4.6 6.4 2.5 2.1 2.5 -2.1 -1.8 -1.7
Crohns Disease (2012) 0.9 1.5 1.8 1.2 1.4 1.2 -1.2 -1.3 -1.1
Mean Putamen Volume 1.1 1.3 2.9 0.7 1.7 0.6 -1.3 -1.1 -0.9
Fasting Glucose 0.5 0.6 0.9 -1.0 -0.9 -0.9 0.7 -0.4 0.5
HbA1C 0.3 0.4 1.2 -1.1 -0.0 -0.7 0.5 -0.4 0.2
HDL Cholesterol 0.2 0.3 1.1 -0.0 -0.0 0.3 -0.6 -1.1 -0.6
LDL Cholesterol 1.1 1.7 3.1 -1.5 -1.1 -1.4 1.0 0.9 1.8
Lupus 0.2 0.3 1.0 -0.1 -1.0 -0.5 0.2 0.1 0.6
Neuroticism (2016) 0.2 0.2 0.5 -0.1 -0.1 -0.4 0.5 0.7 0.7
Primary Biliary Cirrhosis 3.5 4.9 8.1 -1.8 -2.8 -2.1 1.6 1.8 2.9
Rheumatoid Arthritis 1.3 1.7 2.5 -1.0 -1.5 -1.0 1.6 1.4 1.4
Schizophrenia (2014) 3.4 7.4 11.7 1.8 2.4 2.2 -2.7 -3.4 -3.4
Triglycerides 0.0 0.1 0.3 -0.2 0.1 -0.1 -0.1 -0.5 0.0
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.5 -0.5 -0.4 -0.5 0.7 0.5 0.1
Ulcerative Colitis 1.2 1.7 2.5 -1.0 -1.1 -1.4 1.5 1.6 1.2
Blood Eosinophil Count 0.6 4.5 7.1 2.0 1.8 2.2 -2.0 -2.7 -2.0
Blood Platelet Count 0.3 3.1 5.1 -1.1 -2.1 -2.3 1.4 1.5 1.9
Blood Red Count 0.3 2.6 6.2 -1.0 -0.6 -1.6 2.5 2.1 1.0
Blood White Count 0.0 0.3 0.8 0.4 -0.9 0.0 0.7 -0.3 -0.2
Heel T-Score 0.5 3.7 8.4 2.1 1.3 2.3 -1.1 -1.1 -2.9
BMI 0.3 1.7 5.7 2.4 0.4 1.7 -0.8 0.6 -0.6
Height 0.0 0.8 2.6 0.4 -0.5 0.2 1.2 1.6 0.6
Waist Hip Ratio (WHR) 0.5 2.3 8.9 -0.4 0.4 -1.1 1.2 3.0 1.4
Systolic Blood Pressure 4.8 23.8 29.9 -5.1 -5.4 -4.9 5.5 3.5 4.6
Smoking Status 2.4 5.6 8.6 2.0 2.2 2.7 -1.8 -2.5 -2.9
Allergy or Eczema 0.1 0.4 0.8 -0.6 -0.9 -0.5 0.6 0.6 0.1
Cardiovascular Disease 1.8 5.9 10.4 -1.5 -3.2 -2.0 2.8 2.3 2.4
Hypothyroidism (self reported) 0.3 0.7 1.2 -1.1 -0.6 -1.1 0.4 0.4 0.9
Respiratory disease 1.3 2.8 4.7 -0.5 -2.0 -1.1 2.1 2.2 1.5
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.6 0.7 0.4 0.9 -0.9 -0.7 -1.3
Lung FEV1/FVC ratio 0.3 1.4 2.8 -1.7 -1.7 -0.9 0.8 -0.5 1.0
Lung FVC 0.1 0.3 0.8 0.5 0.1 0.8 -0.2 -0.5 -0.9
Neuroticism 0.3 0.6 1.6 -1.3 0.3 -0.9 0.1 -1.0 0.4
Chronotype (morning person) 3.3 7.5 18.1 1.3 2.5 2.3 -2.9 -4.2 -2.4
Hair Pigment 0.0 0.7 2.0 0.6 1.4 0.9 -0.5 -0.3 -0.7
Tanning 0.1 0.7 2.1 0.4 0.1 1.1 -0.3 -1.4 -0.9
Hand grip strength (left) 0.2 0.6 3.2 0.3 -0.0 0.4 -0.2 -1.8 -0.3
Number of treatments/medications taken 4.0 7.1 11.0 -2.3 -3.3 -2.6 2.9 1.9 2.8
Average weekly spirits intake 1.2 1.5 3.3 -0.5 0.2 -1.4 -0.3 1.8 1.8
Sensitivity / hurt feelings 1.7 3.0 5.7 1.0 2.4 1.6 -1.6 -1.8 -1.6
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 0.1 -0.4 -0.3 0.3 0.1 0.4
Hearing difficulty/problems: Yes 2.2 3.4 4.6 -2.2 -1.7 -1.9 1.6 1.8 1.8
Relative age of first facial hair 0.2 0.3 1.0 -0.6 0.5 -0.6 -0.0 -1.0 0.1
Other serious medical condition/disability diagnosed by doctor 1.4 1.9 3.4 -1.6 -1.6 -1.9 1.0 0.6 1.3
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.5 -0.1 -0.7 -0.4 0.3 0.1 0.7
Ever had hysterectomy (womb removed) 4.8 5.4 7.7 -2.8 -1.8 -2.7 2.2 1.6 2.7
Systolic blood pressure, automated reading 4.6 13.3 15.9 -4.0 -3.7 -3.9 3.2 3.2 3.7
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 3.0 -0.6 0.4 -0.0 -0.7 -1.7 -0.3
Angina 0.4 0.6 1.4 0.5 1.2 0.3 -0.5 -0.3 -1.1
Medication for hormone replacement therapy 0.4 0.5 0.8 0.8 0.7 0.8 -0.9 -0.1 -0.4
Vitamin and mineral supplements 1.4 1.9 6.6 -0.1 1.0 0.7 -1.6 -2.6 -0.9
Supplements: Zinc 0.3 0.4 1.0 0.7 0.6 0.4 0.1 1.0 -0.4
Medication: Co-codamol 1.9 2.2 3.7 -1.3 -1.1 -1.9 1.6 1.3 1.6
Medication: Metformin 0.7 1.0 2.5 -0.9 -1.6 -0.7 1.4 -0.1 0.2
Diabetes (father) 0.3 0.4 1.0 0.9 -0.2 0.4 -0.6 1.0 0.2
Diabetes (mother) 0.1 0.2 0.6 -0.7 -0.2 -0.6 0.2 0.0 0.3
Severe depression (siblings) 0.3 0.3 0.8 -0.7 -0.3 -0.8 0.2 0.1 0.9
Pack years adult smoking proportion 0.2 0.3 0.8 0.1 -0.6 -0.3 0.2 0.9 0.7
Impedance of leg (right) 0.8 3.6 7.7 -2.8 -1.4 -2.3 1.8 1.2 1.6
Leg fat-free mass (left) 0.1 0.8 2.6 1.6 0.0 1.1 -0.4 0.9 -0.1
Trunk fat percentage 0.1 0.2 0.7 0.6 0.2 0.4 -0.3 0.8 0.1
Hand grip strength (right) 0.1 0.3 0.6 -0.5 -0.8 -0.8 0.4 -0.5 0.5
Townsend deprivation index at recruitment 0.1 0.2 0.8 -0.0 -0.3 -0.3 0.1 0.9 0.1
Current tobacco smoking 1.8 2.9 4.8 2.2 1.4 2.0 -0.9 -1.3 -2.0
Average weekly fortified wine intake 0.4 0.5 1.2 -1.1 0.2 -0.9 -0.2 -0.4 0.7
Maternal smoking around birth 0.5 0.7 1.3 -1.1 -0.6 -0.9 1.1 -0.2 0.8
Fed-up feelings 0.2 0.3 0.8 -0.5 -0.0 -0.8 0.9 -0.2 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.2 1.5 0.6 1.0 -0.1 0.2 -0.6
Relative age voice broke 0.1 0.2 0.7 -0.2 0.3 -0.1 0.2 -0.9 -0.5
Taking other prescription medications 0.8 1.3 1.9 -0.9 -1.3 -1.2 1.1 0.9 1.4
Age when periods started (menarche) 0.3 0.8 2.0 -1.4 0.6 -1.1 0.6 -0.9 0.1
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.1 -0.9 0.2 -1.5 0.5 0.5 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 2.1 1.5 0.5 1.2 -0.7 -0.1 -1.2
Tinnitus: Yes, but not now, but have in the past 2.1 2.2 4.1 1.5 2.0 1.3 -1.6 -0.0 -1.6
Qualifications: CSEs or equivalent 0.2 0.3 1.0 1.0 0.4 0.6 -0.7 0.2 -0.1
Serious illness, injury or assault to yourself 0.7 0.8 2.2 -1.0 -1.5 -0.5 0.6 -1.0 0.0
High blood pressure 1.0 2.7 6.9 -0.9 -2.6 -1.2 1.7 1.5 1.4
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.1 -0.4 -1.0 -0.5 0.7 1.4 0.8
Multivitamins +/- minerals 1.3 1.6 4.2 0.2 -1.4 -0.8 1.4 2.0 0.8
Stomach or abdominal pain in last month 1.2 1.5 2.6 1.4 1.0 1.4 -1.0 -0.4 -1.6
Supplements: Glucosamine 0.1 0.2 0.4 -0.2 0.6 -0.5 0.2 -0.4 -0.3
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.8 -0.6 0.3 -0.4 0.9 -0.6 0.2
Medication: Atenolol 0.2 0.3 0.5 0.7 -0.3 0.2 -0.3 -0.7 -0.7
Medication: Levothyroxine sodium 0.5 0.9 2.7 -0.6 -0.5 -1.0 0.2 1.6 1.0
Sitting height 0.0 0.2 0.8 0.2 -0.0 0.5 0.9 -0.1 -0.4
Chronic bronchitis/emphysema (father) 0.5 0.6 1.4 -1.1 0.3 -1.2 0.2 -0.9 0.5
High blood pressure (mother) 2.0 2.8 6.1 -1.1 -1.8 -1.4 1.2 2.5 1.8
Body mass index (BMI) 0.2 0.9 2.8 1.7 0.2 1.0 -0.5 1.1 -0.0
Impedance of leg (left) 0.7 3.2 7.2 -2.7 -1.4 -2.1 1.7 0.9 1.2
Leg predicted mass (left) 0.2 0.8 2.8 1.7 0.1 1.1 -0.5 0.8 -0.2
Trunk fat mass 0.1 0.4 1.5 0.8 0.0 0.4 -0.1 1.2 0.3
Waist circumference 0.3 1.0 4.4 0.5 -0.3 -0.2 0.3 2.1 0.9
Number of incorrect matches in round 1.0 1.7 3.8 -1.9 -0.7 -1.9 0.1 -0.4 1.5
Past tobacco smoking 1.3 2.5 4.3 -0.8 -1.7 -1.7 0.5 2.1 2.0
Alcohol usually taken with meals 0.0 0.1 0.3 -0.1 0.2 -0.1 -0.2 -0.2 -0.5
Nervous feelings 1.9 3.6 6.4 -2.1 -0.9 -2.4 1.5 1.4 2.5
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.3 3.3 -1.6 -1.8 -1.8 1.4 1.1 1.4
Hearing difficulty/problems with background noise 0.2 0.3 0.9 -0.1 0.9 0.3 -0.9 0.1 -0.4
Hair/balding pattern: Pattern 2 0.0 0.1 0.2 0.1 -0.3 0.4 0.0 -0.2 -0.2
Had menopause 0.3 0.3 0.9 -0.5 -0.3 -0.7 0.9 0.4 0.4
Had other major operations 0.6 0.7 1.4 0.2 1.2 0.5 -0.6 -1.2 -0.7
Forced vital capacity (FVC) 0.5 1.8 3.8 -1.0 -1.9 -1.2 1.5 1.2 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 3.1 1.8 0.7 1.6 -0.6 -0.1 -1.6
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 1.2 -0.0 -0.1 -0.0 0.4 1.1 -0.0
Qualifications: None of the above 1.6 3.4 4.8 -1.8 -1.6 -1.9 2.0 1.5 2.2
Financial difficulties in last 2 years 0.3 0.4 0.8 0.1 -0.9 -0.5 0.3 0.7 0.8
Mouth/teeth dental problems 0.5 0.8 2.2 0.4 0.4 0.4 -1.5 -1.3 -0.4
Heart attack 0.1 0.1 0.2 -0.2 0.2 -0.2 0.2 -0.4 -0.4
Allergy 1.7 3.9 6.0 1.4 2.5 1.6 -1.9 -2.4 -1.9
Pain all over the body in last month 0.3 0.3 0.8 -0.6 -0.8 -0.2 0.9 0.3 -0.0
Diabetes (self-reported) 0.4 0.6 1.5 -1.2 -0.1 -1.1 0.1 -0.9 0.4
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.7 0.0 -0.8 0.1 0.7 0.8 0.2
Medication: Ramipril 0.2 0.3 0.9 0.3 -0.6 0.2 0.4 0.9 -0.1
Medication: Simvastatin 0.1 0.1 0.4 -0.1 -0.6 -0.1 0.5 0.1 0.2
Fluid intelligence score 1.3 2.7 5.7 -1.1 -2.4 -1.3 1.5 1.7 1.5
Illnesses of siblings 1.9 2.7 4.9 1.1 2.2 1.0 -2.2 -1.7 -1.2
Neuroticism score 0.3 0.6 1.4 -1.2 -0.1 -1.0 0.6 -0.1 0.8
Weight 0.1 0.7 2.3 1.1 -0.4 0.5 0.2 1.5 0.4
Impedance of arm (right) 0.2 0.7 2.5 -1.6 -0.2 -0.9 0.3 -0.9 0.2
Arm fat percentage (right) 0.1 0.4 1.1 1.1 0.1 0.8 -0.4 0.6 0.0
Trunk fat-free mass 0.1 0.8 2.0 1.0 -1.0 0.3 0.6 1.4 0.5
Hip circumference 0.1 0.5 1.3 1.1 -0.4 0.6 0.1 1.1 0.1
Time employed in main current job 1.9 2.2 3.9 0.7 1.6 1.1 -1.2 -1.8 -2.0
Alcohol intake versus 10 years previously 0.2 0.4 1.1 -0.1 -1.1 0.3 0.7 -0.2 -0.7
Father’s age at death 0.7 0.9 1.9 -0.6 -0.4 -1.1 0.7 1.1 1.4
Worrier / anxious feelings 0.3 0.5 1.8 -0.2 1.3 -0.7 -0.4 0.1 0.7
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 5.2 0.5 -1.5 -0.4 1.3 2.3 0.6
Falls in the last year 0.2 0.2 0.4 0.6 0.4 0.6 -0.6 0.4 -0.4
Hair/balding pattern: Pattern 3 0.6 0.8 1.6 0.8 0.8 0.7 -0.4 -1.3 -1.2
Number of live births 1.1 1.5 3.1 1.3 0.8 1.7 -0.7 -1.0 -1.5
Forced expiratory volume in 1-second (FEV1) 1.4 4.9 9.0 -1.5 -3.0 -1.8 2.4 2.1 2.0
Pulse rate 0.4 0.6 1.9 -0.4 -0.6 -0.6 -0.0 1.4 0.9
Happiness 0.6 0.7 1.3 -1.1 -0.4 -1.1 0.9 -0.3 0.8
Noisy workplace 0.1 0.2 0.7 0.2 -0.2 0.3 0.2 0.1 -0.8
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.0 1.0 0.8 0.5 -0.9 -0.4 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.9 0.0 -1.0 -0.1 0.2 -0.1 0.4
Mouth/teeth dental problems: Dentures 1.0 1.7 2.6 -1.3 -1.3 -1.4 1.6 1.0 1.2
Asthma 4.0 7.9 12.5 -2.1 -3.5 -2.5 2.9 2.8 2.9
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 3.6 1.7 -0.3 1.9 -0.1 -0.8 -1.7
Medication: Cholesterol lowering 0.4 0.7 1.1 -0.5 -0.7 -1.1 0.6 1.0 0.9
Depression (self-reported) 0.3 0.3 0.7 0.6 -0.1 0.8 0.1 0.7 -0.5
Medication: Lansoprazole 0.2 0.2 0.4 0.2 0.6 0.2 -0.6 -0.5 -0.4
Prospective memory result 1.7 2.1 4.2 1.0 1.9 1.2 -1.1 -1.0 -2.0
Lung cancer (father) 1.4 1.6 4.3 -2.1 -0.3 -1.6 0.9 -0.3 1.4
Illnesses of mother 3.8 4.7 6.3 1.8 2.2 2.3 -1.6 -2.4 -2.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.3 -0.5 -1.5 -0.5 1.1 1.0 0.7
Pulse wave Arterial Stiffness index 0.8 1.0 1.8 1.3 0.4 1.2 -1.0 -0.4 -1.1
Impedance of arm (left) 0.1 0.7 2.6 -1.6 0.0 -0.8 0.1 -1.0 -0.0
Arm fat mass (right) 0.1 0.6 1.5 1.2 -0.2 0.6 -0.2 1.2 0.3
Trunk predicted mass 0.1 0.8 2.1 1.0 -1.0 0.3 0.6 1.4 0.5
Standing height 0.1 1.5 2.1 -1.2 -1.3 -1.1 1.5 1.1 1.0
Length of working week for main job 0.7 0.8 1.6 1.3 0.7 1.2 -0.4 0.9 -0.5
Exposure to tobacco smoke at home 0.4 0.4 1.6 0.1 0.2 0.3 0.1 -1.3 -0.9
Breastfed as a baby 0.4 0.5 1.6 0.9 0.0 0.3 -0.3 1.2 -0.4
Tense / ‘highly strung’ 1.7 2.8 4.1 -1.8 -1.9 -1.9 1.4 0.5 2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 2.3 -1.2 -1.4 -1.4 1.0 1.2 1.5
Hair/balding pattern: Pattern 4 0.7 1.7 2.6 -1.1 -1.2 -1.1 1.6 1.6 1.2
Birth weight of first child 0.4 0.6 1.4 -1.2 -0.5 -1.1 0.6 0.6 0.6
Peak expiratory flow (PEF) 3.7 8.7 15.8 -1.6 -4.0 -2.0 3.0 3.8 2.4
Pulse wave reflection index 3.4 4.2 5.5 2.2 1.7 2.2 -1.8 -1.9 -2.4
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.4 -1.2 -1.1 -0.9 0.8 1.0 0.6
Loud music exposure frequency 0.6 0.7 2.0 -0.4 -0.8 -0.6 1.4 0.6 0.8
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 0.7 0.2 0.5 -0.7 -0.5 -0.7
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.5 -0.1 -0.2 0.0 0.7 0.4 -0.2
Blood clot in the leg (DVT) 0.1 0.1 0.6 -0.0 0.3 -0.2 0.1 -0.8 -0.2
Medication: Paracetamol 3.3 5.4 6.6 -2.4 -2.5 -2.1 2.6 2.0 2.4
Headache pain in last month 0.1 0.2 0.6 0.7 -0.2 0.4 0.2 0.8 0.0
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 5.3 1.6 2.3 2.1 -1.6 -1.2 -1.7
Glaucoma (self-reported) 0.4 0.5 1.7 -0.2 1.1 0.1 -0.4 -1.3 0.1
Gout (self-reported) 0.4 0.6 1.1 -0.6 -1.0 -0.7 0.6 0.7 1.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.2 -0.4 0.2 -0.4 -0.4 0.4 0.2
Medication: Amlodipine 0.4 0.6 1.4 -0.6 -1.2 -0.6 0.7 0.4 0.8
Medication: Ventolin 100micrograms inhaler 1.2 1.5 2.6 -0.6 -0.6 -1.3 1.3 1.6 1.5
Birth weight 0.3 0.8 2.5 1.6 0.3 0.8 -0.9 0.6 -0.4
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.6 0.6 -0.0 0.6 0.1 -0.1 -0.8
High blood pressure (siblings) 1.8 2.7 5.5 -0.9 -2.4 -0.9 1.7 2.1 1.3
Forced vital capacity (FVC), Best measure 0.0 0.1 0.5 0.2 -0.7 0.3 0.3 0.3 -0.1
Body fat percentage 0.1 0.2 0.9 0.6 0.2 0.4 -0.2 0.9 0.1
Leg fat percentage (right) 0.2 0.8 3.5 0.1 -0.3 -0.4 0.5 1.9 1.1
Arm fat-free mass (right) 0.2 0.8 3.0 0.9 -0.7 0.2 0.4 1.7 0.5
Exposure to tobacco smoke outside home 0.9 1.3 4.0 -0.2 -0.8 -0.5 1.5 2.0 0.5
Comparative body size at age 10 0.3 1.0 2.2 1.0 1.5 0.7 -1.1 0.7 -0.5
Number of full brothers 0.2 0.2 0.7 -0.7 -0.0 -0.2 0.8 -0.0 0.1
Worry too long after embarrassment 1.4 2.4 5.3 0.4 1.9 1.2 -1.3 -2.3 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 2.9 0.1 -0.5 -0.5 0.3 1.7 0.3
Wheeze or whistling in the chest in last year 1.0 1.8 4.6 -0.3 -1.5 -0.8 1.6 2.1 0.7
Number of children fathered 0.5 0.5 1.1 -1.0 -0.4 -1.0 -0.2 0.0 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.5 -0.8 0.2 -0.0 -0.1 -1.2 -0.3
Age at first live birth 1.1 2.0 2.8 1.3 1.6 1.5 -1.0 -1.3 -1.7
Pulse wave peak to peak time 1.4 1.6 2.7 -1.7 -0.8 -1.5 1.3 0.5 1.4
Health satisfaction 0.2 0.2 0.4 -0.6 0.1 -0.6 0.4 0.3 0.5
Shortness of breath walking on level ground 0.2 0.3 0.8 0.5 -0.0 0.9 -0.1 -0.4 -0.6
Qualifications: College or University degree 1.8 5.6 9.0 2.2 1.7 2.7 -1.9 -2.5 -3.0
Eye problems/disorders: None of the above 0.2 0.3 1.2 0.0 -0.3 0.1 0.4 1.1 0.4
Mouth/teeth dental problems: Loose teeth 4.6 5.5 7.1 2.0 2.6 2.6 -2.0 -2.0 -2.7
Emphysema/chronic bronchitis 0.3 0.4 0.8 -0.6 -0.4 -0.7 0.6 0.9 0.5
Medication for pain relief, constipation, heartburn 0.6 1.1 1.9 1.0 1.4 0.7 -1.3 -0.2 -1.1
Neck or shoulder pain in last month 1.4 2.0 4.3 -1.2 -1.0 -1.5 1.3 2.1 1.2
Medication: Blood pressure 2.0 3.5 6.9 -1.8 -2.6 -2.2 1.6 0.8 1.7
Angina (self-reported) 0.3 0.4 1.0 0.4 1.0 0.1 -0.5 -0.2 -0.9
Migraine (self-reported) 0.3 0.3 0.8 -0.2 -0.3 -0.6 0.1 0.8 0.9
Medication: Ibuprofen 0.7 0.8 1.9 1.2 -0.5 1.4 0.2 -0.1 -1.0
Medication: Allopurinol 0.9 1.1 2.1 -1.4 -0.9 -1.4 0.4 0.5 1.3
Medication: Omeprazole 0.6 0.7 2.0 -1.4 -0.1 -1.0 0.4 -0.9 -0.0
Medication: Seretide 50 evohaler 2.1 2.4 5.3 -1.7 -0.8 -1.9 1.0 1.3 2.3
Mean time to correctly identify matches 0.4 0.8 1.1 0.9 0.9 0.7 -1.0 -0.8 -1.1
Heart disease (mother) 1.7 2.1 3.2 -1.4 -0.8 -1.5 1.4 1.8 1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.3 -0.8 -1.1 -0.8 0.5 0.3 0.7
Whole body fat mass 0.1 0.5 1.8 0.9 -0.0 0.5 -0.0 1.4 0.3
Leg fat mass (right) 0.2 0.7 2.9 0.7 -0.1 0.2 0.2 1.7 0.7
Arm predicted mass (right) 0.1 0.6 1.7 1.1 -0.4 0.4 0.1 1.3 0.2
Pulse rate, automated reading 1.3 4.1 10.1 -1.4 -1.9 -1.6 1.6 3.2 1.9
Alcohol intake frequency. 2.6 6.1 13.6 -1.8 -3.7 -1.7 2.7 2.6 1.8
Comparative height size at age 10 0.1 0.3 0.5 -0.7 -0.3 -0.6 0.4 0.6 0.7
Number of full sisters 0.2 0.3 0.5 0.7 0.4 0.7 -0.4 0.3 -0.5
Suffer from ‘nerves’ 5.9 9.2 14.5 -2.5 -3.0 -3.1 2.4 3.2 3.8
Overall health rating 2.8 5.9 7.9 -1.5 -2.7 -2.4 2.2 2.8 2.8
Chest pain or discomfort 0.4 0.6 1.3 -0.1 -0.9 -0.4 1.1 1.0 0.4
Had major operations 0.0 0.1 0.2 0.0 -0.1 0.2 0.3 0.5 -0.2
Age at last live birth 3.2 4.7 6.1 2.2 2.3 2.5 -1.6 -1.9 -2.4
Family relationship satisfaction 0.2 0.3 0.8 -0.2 -0.1 -0.1 0.7 -0.9 -0.6
Leg pain on walking 0.2 0.2 0.8 -0.2 -0.0 0.0 0.9 0.7 -0.0
Qualifications: NVQ or HND or HNC or equivalent 2.3 2.8 4.2 -1.3 -2.1 -1.6 1.7 1.7 1.6
Commuting to job workplace: Car/motor vehicle 0.9 1.0 3.0 -0.2 -0.5 -0.7 0.3 1.7 1.4
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 1.5 0.8 1.2 1.2 -1.0 -1.0 -1.2
Medication: Aspirin 0.3 0.4 0.9 0.2 0.8 0.0 -0.8 -1.0 -0.1
Supplements: Vitamin C 0.2 0.3 0.8 0.1 0.6 0.2 0.7 0.9 -0.1
Knee pain experienced in last month 0.1 0.2 0.5 0.7 -0.5 -0.0 0.4 0.3 -0.1
Hypertension (Self-reported) 1.0 2.8 6.7 -0.9 -2.6 -1.3 1.7 1.4 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.5 1.9 1.1 1.3 1.3 -1.2 -0.8 -1.4
Illnesses of father: Heart disease 0.3 0.4 1.3 -0.1 -0.7 -0.3 1.1 0.7 0.0
Illnesses of siblings: Diabetes 4.0 4.9 7.3 -1.7 -2.4 -2.0 2.0 2.7 2.4
Smoking status: Previous 0.1 0.2 0.4 -0.3 0.6 0.4 -0.0 -0.6 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.7 -0.4 -1.0 -0.3 0.6 1.3 0.9
Whole body fat-free mass 0.1 0.7 2.0 1.4 -0.5 0.7 0.1 1.2 0.1
Leg fat-free mass (right) 0.2 0.9 3.0 1.7 0.1 1.3 -0.5 0.5 -0.5
Arm fat percentage (left) 0.1 0.5 1.3 1.2 0.4 0.8 -0.6 0.5 -0.2
Average weekly red wine intake 0.9 1.3 4.5 0.1 0.9 0.6 -0.8 -2.1 -1.3
Handedness (chirality/laterality): Left-handed 1.2 1.4 2.6 -0.7 -0.7 -0.9 1.4 1.5 1.6
Mood swings 0.1 0.2 0.4 -0.2 0.1 -0.4 0.6 -0.5 0.2
Loneliness, isolation 0.2 0.2 0.4 -0.2 0.6 -0.7 0.3 0.2 0.6
Long-standing illness, disability or infirmity 2.0 3.0 5.1 -1.1 -2.1 -1.6 1.7 2.3 1.6
Ever had bowel cancer screening 0.7 0.8 1.7 -1.3 -0.7 -0.8 1.0 0.6 0.8
Diabetes diagnosed by doctor 0.1 0.2 0.4 -0.6 0.0 -0.6 0.0 -0.4 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 0.7 0.7 0.9 0.7 -0.6 0.4 -0.8
Friendships satisfaction 0.3 0.4 1.0 -1.0 0.6 -0.6 0.5 -0.6 0.1
Qualifications: nursing, teaching 0.7 1.1 2.9 1.7 -0.3 1.5 -0.6 0.2 -1.0
Commuting to job workplace: Walk 3.3 3.5 4.5 -1.4 -1.9 -2.1 1.9 2.1 1.8
Eye problems/disorders: Cataract 0.0 0.0 0.1 0.1 -0.0 -0.2 0.0 0.1 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 5.1 2.1 2.3 1.9 -1.0 0.2 -1.3
Medication for cholesterol 0.1 0.2 0.9 -0.2 0.9 -0.3 -0.3 0.4 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.6 0.4 0.7 0.6 -0.6 -0.5 -0.8
Back pain experienced in last month 5.2 7.6 13.9 -2.4 -3.7 -2.4 2.6 2.6 2.4
Mineral and other dietary supplements 0.1 0.1 0.3 -0.1 -0.3 0.4 -0.5 0.5 0.1
Breast cancer (self-reported) 0.1 0.1 0.2 -0.5 0.3 -0.2 -0.2 -0.4 -0.0
Asthma (self-reported) 3.4 6.8 10.8 -1.9 -3.3 -2.2 2.7 2.6 2.7
Osteoporosis (self-reported) 2.3 2.8 4.1 -1.7 -0.8 -1.6 1.8 1.9 2.0
Osteoarthritis (self-reported) 1.6 2.0 4.3 0.9 1.4 1.3 -1.2 -2.1 -1.4
Medication: Aspirin 0.2 0.2 0.8 -0.0 0.5 -0.1 -0.6 -0.9 0.1
Medication: Gliclazide 0.1 0.1 0.2 -0.2 0.2 -0.2 -0.2 0.5 0.3
Illnesses of father: None of the above (group 1) 0.5 0.7 1.3 0.2 1.1 0.7 -1.0 -0.9 -0.5
Smoking status: Current 2.8 4.5 6.7 2.3 1.9 2.3 -1.1 -2.0 -2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.1 -1.1 -0.9 -0.9 0.6 0.7 0.8
Whole body water mass 0.1 0.7 1.8 1.3 -0.6 0.7 0.1 1.2 0.1
Leg predicted mass (right) 0.2 0.9 2.9 1.7 0.1 1.2 -0.5 0.5 -0.4
Arm fat mass (left) 0.2 0.7 1.9 1.4 0.2 0.8 -0.4 1.1 0.1
Number of self-reported non-cancer illnesses 2.0 3.4 7.9 -1.0 -2.8 -1.2 2.2 1.7 1.5
Average weekly champagne plus white wine intake 1.9 2.6 4.2 1.0 1.9 1.3 -1.3 -1.9 -2.1
Miserableness 0.1 0.2 0.6 0.2 -0.0 0.2 0.5 0.8 -0.5
Guilty feelings 1.2 1.8 6.7 -0.4 1.1 0.2 -1.2 -2.6 -1.1
Wears glasses or contact lenses 1.6 1.8 4.4 -2.1 -0.7 -2.0 1.0 -0.0 1.1
Ever taken oral contraceptive pill 0.3 0.4 0.9 0.9 0.9 0.4 -0.5 -0.5 -0.0
Hearing aid user 2.6 2.9 6.4 -2.5 -1.4 -2.1 1.2 0.4 1.8
Mother’s age at death 0.2 0.3 0.9 0.7 -0.1 0.2 -0.0 0.9 -0.1
Financial situation satisfaction 0.2 0.3 0.7 -0.5 -0.4 -0.5 0.4 0.8 0.2
Tinnitus: Yes, now most or all of the time 2.8 3.3 5.5 -1.6 -1.8 -2.4 0.8 1.7 2.2
Commuting to job workplace: Public transport 1.0 1.1 1.4 1.1 1.0 1.1 -0.9 -1.2 -1.1
Eye problems/disorders: Glaucoma 0.6 0.7 1.1 -1.0 -0.5 -0.9 0.8 -0.6 1.0
Medication: Blood pressure 0.2 0.3 0.5 0.6 -0.7 0.5 0.7 -0.2 -0.2
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.1 0.5 0.2 1.1 0.3 -0.0 -0.9
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.4 -0.9 -0.8 -1.5 1.6 0.3 1.2
High cholesterol (Self-reported) 0.8 1.4 2.3 -0.7 -1.5 -0.9 1.4 1.3 1.0
Medication: Bendroflumethiazide 0.2 0.3 1.0 -0.1 -1.0 -0.1 0.5 0.6 0.1
Medication: Paracetamol 5.4 8.3 10.2 -3.1 -2.7 -2.9 3.2 2.3 3.0
Medication: Lisinopril 0.1 0.1 0.2 0.3 -0.5 0.1 -0.3 -0.5 -0.4
Medication: Atorvastatin 1.3 1.7 3.1 -1.4 -1.3 -1.8 1.0 0.8 1.2
Illnesses of father: High blood pressure 0.3 0.4 0.8 0.7 0.0 0.8 -0.6 -0.9 -0.4
Alcohol drinker status: Never 0.3 0.3 0.6 0.6 -0.8 0.7 0.4 0.1 -0.6
Ever smoked 3.1 5.4 8.9 1.7 2.6 2.5 -0.9 -3.0 -2.7
Basal metabolic rate 0.1 0.7 1.8 1.3 -0.5 0.6 0.1 1.4 0.2
Leg fat percentage (left) 0.2 0.6 2.7 0.5 -0.0 0.0 0.2 1.6 0.6
Arm fat-free mass (left) 0.2 1.0 3.0 1.3 -0.7 0.5 0.4 1.7 0.4
Number of operations (self-reported) 0.6 0.9 2.0 0.5 1.4 0.8 -0.7 -1.0 -0.8
Average weekly beer plus cider intake 2.8 4.1 8.7 3.0 1.4 2.4 -1.7 -0.8 -2.1
Irritability 0.7 1.1 1.9 -1.2 -0.3 -1.4 1.2 0.1 1.3
Risk taking 0.8 1.1 5.2 0.6 0.6 0.7 -0.1 -2.3 -0.8
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 -0.4 0.8 -0.3 0.6 -0.3 0.0
Fractured/broken bones in last 5 years 0.3 0.4 1.0 -1.0 0.4 0.3 0.5 -0.9 -0.5
Age started oral contraceptive pill 0.2 0.3 1.0 -0.3 0.6 -0.2 -0.5 -1.0 0.2
Diastolic blood pressure, automated reading 2.3 7.1 8.0 -2.6 -2.8 -2.7 2.4 2.7 2.7
Ever depressed for a whole week 0.6 0.7 1.3 -1.2 -0.1 -1.1 1.1 0.7 0.7
Unable to work because of sickness or disability 0.1 0.1 0.3 -0.0 -0.4 0.1 0.2 0.2 -0.5
Commuting to job workplace: Cycle 4.0 4.9 12.2 0.8 2.0 1.6 -1.7 -3.5 -2.6
Myopia 1.0 1.4 1.9 1.1 0.9 1.2 -1.4 -1.2 -1.3
Vascular/heart problems diagnosed by doctor 0.5 1.4 4.1 0.5 2.0 0.8 -1.3 -1.1 -0.8
Cholesterol lowering medication 0.5 0.7 2.4 -0.7 -1.6 -0.6 0.8 -0.0 0.4
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.1 -0.9 -0.1 -0.6 0.0 -1.1 -0.1
Pain experienced in last month 0.3 0.6 1.3 0.8 1.1 0.6 -0.9 -0.6 -0.2
Supplements: Calcium 0.4 0.4 1.1 1.1 0.1 0.7 -0.5 0.7 -0.2
Basal cell carcinoma (self-reported) 0.5 0.5 1.4 1.2 0.8 0.8 0.4 0.4 -0.5
Heart attack/myocardial infarction (self-reported) 0.0 0.1 0.1 -0.1 0.1 -0.2 0.3 -0.3 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 -0.1 0.1 -0.4 0.3 -0.4 0.0
Heart disease (siblings) 0.3 0.4 0.9 0.5 0.2 1.0 -0.1 -0.5 -0.8
Alcohol drinker status: Previous 1.0 1.1 1.9 -0.7 -1.2 -0.7 1.0 1.4 1.1
Pack years of smoking 0.3 0.4 0.8 -0.2 -0.6 -0.5 0.3 0.8 0.9
Impedance of whole body 0.2 1.2 4.6 -2.1 -0.4 -1.3 0.8 -0.2 0.5
Leg fat mass (left) 0.2 0.7 2.6 1.0 0.1 0.4 -0.0 1.6 0.4
Arm predicted mass (left) 0.2 0.9 2.7 1.3 -0.7 0.6 0.2 1.6 0.3