Hub : Genes

NMD3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1100	0.0300	0.0e+00	0.132	0.155	0.154	0.148	0.151	8.5e-16	1.9e-18	2.3e-18	1.2e-17	6.4e-18
2	GTEx	Cells Transformed fibroblasts	0.0850	0.0490	4.6e-03	0.017	NA	-0.003	NA	0.003	1.8e-02	NA	6.3e-01	NA	1.7e-01
3	GTEx	Pancreas	0.0880	0.0450	5.5e-03	0.106	NA	0.055	NA	0.086	3.3e-05	NA	2.3e-03	NA	1.7e-04
4	GTEx	Skin Sun Exposed Lower leg	0.0970	0.0390	1.6e-03	0.017	NA	0.010	NA	0.013	1.4e-02	NA	4.7e-02	NA	2.5e-02
5	METSIM	Adipose	0.0254	0.0141	2.3e-03	0.026	0.014	0.021	0.014	0.028	6.8e-05	3.3e-03	3.7e-04	3.1e-03	4.0e-05
6	TCGA	Thyroid Carcinoma	0.0810	0.0390	2.6e-07	0.082	0.081	0.085	NA	0.079	2.0e-08	2.6e-08	1.3e-08	NA	4.1e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.3	0.5	-0.7	-0.4	-0.7	0.3	0.5	0.3
Bipolar Disorder or Schizophrenia	0.6	1.6	3.3	0.4	1.1	0.8	-1.3	-1.6	-1.8
Depressed Affect (Nagel 2018)	0.1	0.3	0.7	-0.4	0.4	-0.4	0.8	-0.5	-0.2
Depression (Nagel 2018)	0.0	0.0	0.1	0.1	-0.0	-0.1	0.1	-0.3	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.5	1.6	-0.6	-1.3	-0.6	0.4	-0.1	0.5
Neuroticism (Nagel 2018)	0.2	0.6	1.4	-1.0	0.7	-0.7	0.1	-1.2	-0.0
Schizophrenia (2018)	1.9	3.9	6.9	1.0	1.7	1.6	-1.9	-2.6	-2.6
Schizophrenia vs Biploar Disorder	3.8	5.0	7.3	1.6	2.1	2.2	-2.0	-2.6	-2.7
Worry (Nagel 2018)	2.1	4.5	7.3	-2.7	-1.3	-2.7	2.0	0.8	2.5
Alzheimer’s Disease (in mother)	1.6	1.9	2.7	-0.7	-1.6	-1.4	1.5	1.6	1.1
Alzheimer’s Disease (in father)	1.7	1.8	3.0	-0.7	-1.6	-1.1	1.7	1.7	1.0
Alzheimer’s Disease (including proxy)	1.3	1.9	3.9	-0.6	-2.0	-1.3	1.7	1.4	0.9
Crohns Disease (2017)	0.7	1.5	2.9	0.9	1.2	1.3	-0.9	-1.3	-1.7
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	0.5	0.3	0.6	0.5	0.2	-0.8
Ulcerative Colitis (UC)	0.6	1.1	2.9	-0.2	-0.9	-0.4	1.7	1.7	0.3
Major Depression (MDD)	0.0	0.0	0.2	0.0	-0.0	0.4	0.2	-0.1	-0.1
Reaction Time	0.4	0.8	1.7	1.0	0.6	0.9	-0.7	-0.5	-1.3
Verbal and Numeric Reasoning (VNR)	1.4	3.4	6.4	-1.8	-2.5	-1.9	1.7	1.2	1.7
Breast Cancer	0.5	1.2	1.8	1.1	0.9	1.0	-1.2	-0.9	-1.3
Ovarian Cancer	1.4	1.8	4.5	0.1	1.0	1.0	-1.6	-2.1	-1.4
Prostate Cancer	0.6	0.9	2.2	0.7	1.5	0.8	-0.7	0.3	-1.2
Age at First Birth	0.1	0.2	0.6	0.1	0.2	0.2	-0.6	-0.8	-0.1
Bipolar Disorder (2011)	4.1	3.9	5.5	1.7	1.4	2.0	-2.0	-2.3	-2.3
Body Mass Index (BMI) (2010)	2.0	2.8	5.0	2.2	1.5	2.1	-1.4	-0.4	-1.7
Coronary Artery Disease (CAD)	3.8	4.6	6.4	2.5	2.1	2.5	-2.1	-1.8	-1.7
Crohns Disease (2012)	0.9	1.5	1.8	1.2	1.4	1.2	-1.2	-1.3	-1.1
Mean Putamen Volume	1.1	1.3	2.9	0.7	1.7	0.6	-1.3	-1.1	-0.9
Fasting Glucose	0.5	0.6	0.9	-1.0	-0.9	-0.9	0.7	-0.4	0.5
HbA1C	0.3	0.4	1.2	-1.1	-0.0	-0.7	0.5	-0.4	0.2
HDL Cholesterol	0.2	0.3	1.1	-0.0	-0.0	0.3	-0.6	-1.1	-0.6
LDL Cholesterol	1.1	1.7	3.1	-1.5	-1.1	-1.4	1.0	0.9	1.8
Lupus	0.2	0.3	1.0	-0.1	-1.0	-0.5	0.2	0.1	0.6
Neuroticism (2016)	0.2	0.2	0.5	-0.1	-0.1	-0.4	0.5	0.7	0.7
Primary Biliary Cirrhosis	3.5	4.9	8.1	-1.8	-2.8	-2.1	1.6	1.8	2.9
Rheumatoid Arthritis	1.3	1.7	2.5	-1.0	-1.5	-1.0	1.6	1.4	1.4
Schizophrenia (2014)	3.4	7.4	11.7	1.8	2.4	2.2	-2.7	-3.4	-3.4
Triglycerides	0.0	0.1	0.3	-0.2	0.1	-0.1	-0.1	-0.5	0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.5	-0.4	-0.5	0.7	0.5	0.1
Ulcerative Colitis	1.2	1.7	2.5	-1.0	-1.1	-1.4	1.5	1.6	1.2
Blood Eosinophil Count	0.6	4.5	7.1	2.0	1.8	2.2	-2.0	-2.7	-2.0
Blood Platelet Count	0.3	3.1	5.1	-1.1	-2.1	-2.3	1.4	1.5	1.9
Blood Red Count	0.3	2.6	6.2	-1.0	-0.6	-1.6	2.5	2.1	1.0
Blood White Count	0.0	0.3	0.8	0.4	-0.9	0.0	0.7	-0.3	-0.2
Heel T-Score	0.5	3.7	8.4	2.1	1.3	2.3	-1.1	-1.1	-2.9
BMI	0.3	1.7	5.7	2.4	0.4	1.7	-0.8	0.6	-0.6
Height	0.0	0.8	2.6	0.4	-0.5	0.2	1.2	1.6	0.6
Waist Hip Ratio (WHR)	0.5	2.3	8.9	-0.4	0.4	-1.1	1.2	3.0	1.4
Systolic Blood Pressure	4.8	23.8	29.9	-5.1	-5.4	-4.9	5.5	3.5	4.6
Smoking Status	2.4	5.6	8.6	2.0	2.2	2.7	-1.8	-2.5	-2.9
Allergy or Eczema	0.1	0.4	0.8	-0.6	-0.9	-0.5	0.6	0.6	0.1
Cardiovascular Disease	1.8	5.9	10.4	-1.5	-3.2	-2.0	2.8	2.3	2.4
Hypothyroidism (self reported)	0.3	0.7	1.2	-1.1	-0.6	-1.1	0.4	0.4	0.9
Respiratory disease	1.3	2.8	4.7	-0.5	-2.0	-1.1	2.1	2.2	1.5
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.6	0.7	0.4	0.9	-0.9	-0.7	-1.3
Lung FEV1/FVC ratio	0.3	1.4	2.8	-1.7	-1.7	-0.9	0.8	-0.5	1.0
Lung FVC	0.1	0.3	0.8	0.5	0.1	0.8	-0.2	-0.5	-0.9
Neuroticism	0.3	0.6	1.6	-1.3	0.3	-0.9	0.1	-1.0	0.4
Chronotype (morning person)	3.3	7.5	18.1	1.3	2.5	2.3	-2.9	-4.2	-2.4
Hair Pigment	0.0	0.7	2.0	0.6	1.4	0.9	-0.5	-0.3	-0.7
Tanning	0.1	0.7	2.1	0.4	0.1	1.1	-0.3	-1.4	-0.9
Hand grip strength (left)	0.2	0.6	3.2	0.3	-0.0	0.4	-0.2	-1.8	-0.3
Number of treatments/medications taken	4.0	7.1	11.0	-2.3	-3.3	-2.6	2.9	1.9	2.8
Average weekly spirits intake	1.2	1.5	3.3	-0.5	0.2	-1.4	-0.3	1.8	1.8
Sensitivity / hurt feelings	1.7	3.0	5.7	1.0	2.4	1.6	-1.6	-1.8	-1.6
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.1	-0.4	-0.3	0.3	0.1	0.4
Hearing difficulty/problems: Yes	2.2	3.4	4.6	-2.2	-1.7	-1.9	1.6	1.8	1.8
Relative age of first facial hair	0.2	0.3	1.0	-0.6	0.5	-0.6	-0.0	-1.0	0.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	3.4	-1.6	-1.6	-1.9	1.0	0.6	1.3
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.1	-0.7	-0.4	0.3	0.1	0.7
Ever had hysterectomy (womb removed)	4.8	5.4	7.7	-2.8	-1.8	-2.7	2.2	1.6	2.7
Systolic blood pressure, automated reading	4.6	13.3	15.9	-4.0	-3.7	-3.9	3.2	3.2	3.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.0	-0.6	0.4	-0.0	-0.7	-1.7	-0.3
Angina	0.4	0.6	1.4	0.5	1.2	0.3	-0.5	-0.3	-1.1
Medication for hormone replacement therapy	0.4	0.5	0.8	0.8	0.7	0.8	-0.9	-0.1	-0.4
Vitamin and mineral supplements	1.4	1.9	6.6	-0.1	1.0	0.7	-1.6	-2.6	-0.9
Supplements: Zinc	0.3	0.4	1.0	0.7	0.6	0.4	0.1	1.0	-0.4
Medication: Co-codamol	1.9	2.2	3.7	-1.3	-1.1	-1.9	1.6	1.3	1.6
Medication: Metformin	0.7	1.0	2.5	-0.9	-1.6	-0.7	1.4	-0.1	0.2
Diabetes (father)	0.3	0.4	1.0	0.9	-0.2	0.4	-0.6	1.0	0.2
Diabetes (mother)	0.1	0.2	0.6	-0.7	-0.2	-0.6	0.2	0.0	0.3
Severe depression (siblings)	0.3	0.3	0.8	-0.7	-0.3	-0.8	0.2	0.1	0.9
Pack years adult smoking proportion	0.2	0.3	0.8	0.1	-0.6	-0.3	0.2	0.9	0.7
Impedance of leg (right)	0.8	3.6	7.7	-2.8	-1.4	-2.3	1.8	1.2	1.6
Leg fat-free mass (left)	0.1	0.8	2.6	1.6	0.0	1.1	-0.4	0.9	-0.1
Trunk fat percentage	0.1	0.2	0.7	0.6	0.2	0.4	-0.3	0.8	0.1
Hand grip strength (right)	0.1	0.3	0.6	-0.5	-0.8	-0.8	0.4	-0.5	0.5
Townsend deprivation index at recruitment	0.1	0.2	0.8	-0.0	-0.3	-0.3	0.1	0.9	0.1
Current tobacco smoking	1.8	2.9	4.8	2.2	1.4	2.0	-0.9	-1.3	-2.0
Average weekly fortified wine intake	0.4	0.5	1.2	-1.1	0.2	-0.9	-0.2	-0.4	0.7
Maternal smoking around birth	0.5	0.7	1.3	-1.1	-0.6	-0.9	1.1	-0.2	0.8
Fed-up feelings	0.2	0.3	0.8	-0.5	-0.0	-0.8	0.9	-0.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.2	1.5	0.6	1.0	-0.1	0.2	-0.6
Relative age voice broke	0.1	0.2	0.7	-0.2	0.3	-0.1	0.2	-0.9	-0.5
Taking other prescription medications	0.8	1.3	1.9	-0.9	-1.3	-1.2	1.1	0.9	1.4
Age when periods started (menarche)	0.3	0.8	2.0	-1.4	0.6	-1.1	0.6	-0.9	0.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	-0.9	0.2	-1.5	0.5	0.5	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.1	1.5	0.5	1.2	-0.7	-0.1	-1.2
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	4.1	1.5	2.0	1.3	-1.6	-0.0	-1.6
Qualifications: CSEs or equivalent	0.2	0.3	1.0	1.0	0.4	0.6	-0.7	0.2	-0.1
Serious illness, injury or assault to yourself	0.7	0.8	2.2	-1.0	-1.5	-0.5	0.6	-1.0	0.0
High blood pressure	1.0	2.7	6.9	-0.9	-2.6	-1.2	1.7	1.5	1.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.1	-0.4	-1.0	-0.5	0.7	1.4	0.8
Multivitamins +/- minerals	1.3	1.6	4.2	0.2	-1.4	-0.8	1.4	2.0	0.8
Stomach or abdominal pain in last month	1.2	1.5	2.6	1.4	1.0	1.4	-1.0	-0.4	-1.6
Supplements: Glucosamine	0.1	0.2	0.4	-0.2	0.6	-0.5	0.2	-0.4	-0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.8	-0.6	0.3	-0.4	0.9	-0.6	0.2
Medication: Atenolol	0.2	0.3	0.5	0.7	-0.3	0.2	-0.3	-0.7	-0.7
Medication: Levothyroxine sodium	0.5	0.9	2.7	-0.6	-0.5	-1.0	0.2	1.6	1.0
Sitting height	0.0	0.2	0.8	0.2	-0.0	0.5	0.9	-0.1	-0.4
Chronic bronchitis/emphysema (father)	0.5	0.6	1.4	-1.1	0.3	-1.2	0.2	-0.9	0.5
High blood pressure (mother)	2.0	2.8	6.1	-1.1	-1.8	-1.4	1.2	2.5	1.8
Body mass index (BMI)	0.2	0.9	2.8	1.7	0.2	1.0	-0.5	1.1	-0.0
Impedance of leg (left)	0.7	3.2	7.2	-2.7	-1.4	-2.1	1.7	0.9	1.2
Leg predicted mass (left)	0.2	0.8	2.8	1.7	0.1	1.1	-0.5	0.8	-0.2
Trunk fat mass	0.1	0.4	1.5	0.8	0.0	0.4	-0.1	1.2	0.3
Waist circumference	0.3	1.0	4.4	0.5	-0.3	-0.2	0.3	2.1	0.9
Number of incorrect matches in round	1.0	1.7	3.8	-1.9	-0.7	-1.9	0.1	-0.4	1.5
Past tobacco smoking	1.3	2.5	4.3	-0.8	-1.7	-1.7	0.5	2.1	2.0
Alcohol usually taken with meals	0.0	0.1	0.3	-0.1	0.2	-0.1	-0.2	-0.2	-0.5
Nervous feelings	1.9	3.6	6.4	-2.1	-0.9	-2.4	1.5	1.4	2.5
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	3.3	-1.6	-1.8	-1.8	1.4	1.1	1.4
Hearing difficulty/problems with background noise	0.2	0.3	0.9	-0.1	0.9	0.3	-0.9	0.1	-0.4
Hair/balding pattern: Pattern 2	0.0	0.1	0.2	0.1	-0.3	0.4	0.0	-0.2	-0.2
Had menopause	0.3	0.3	0.9	-0.5	-0.3	-0.7	0.9	0.4	0.4
Had other major operations	0.6	0.7	1.4	0.2	1.2	0.5	-0.6	-1.2	-0.7
Forced vital capacity (FVC)	0.5	1.8	3.8	-1.0	-1.9	-1.2	1.5	1.2	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.1	1.8	0.7	1.6	-0.6	-0.1	-1.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.2	-0.0	-0.1	-0.0	0.4	1.1	-0.0
Qualifications: None of the above	1.6	3.4	4.8	-1.8	-1.6	-1.9	2.0	1.5	2.2
Financial difficulties in last 2 years	0.3	0.4	0.8	0.1	-0.9	-0.5	0.3	0.7	0.8
Mouth/teeth dental problems	0.5	0.8	2.2	0.4	0.4	0.4	-1.5	-1.3	-0.4
Heart attack	0.1	0.1	0.2	-0.2	0.2	-0.2	0.2	-0.4	-0.4
Allergy	1.7	3.9	6.0	1.4	2.5	1.6	-1.9	-2.4	-1.9
Pain all over the body in last month	0.3	0.3	0.8	-0.6	-0.8	-0.2	0.9	0.3	-0.0
Diabetes (self-reported)	0.4	0.6	1.5	-1.2	-0.1	-1.1	0.1	-0.9	0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	0.0	-0.8	0.1	0.7	0.8	0.2
Medication: Ramipril	0.2	0.3	0.9	0.3	-0.6	0.2	0.4	0.9	-0.1
Medication: Simvastatin	0.1	0.1	0.4	-0.1	-0.6	-0.1	0.5	0.1	0.2
Fluid intelligence score	1.3	2.7	5.7	-1.1	-2.4	-1.3	1.5	1.7	1.5
Illnesses of siblings	1.9	2.7	4.9	1.1	2.2	1.0	-2.2	-1.7	-1.2
Neuroticism score	0.3	0.6	1.4	-1.2	-0.1	-1.0	0.6	-0.1	0.8
Weight	0.1	0.7	2.3	1.1	-0.4	0.5	0.2	1.5	0.4
Impedance of arm (right)	0.2	0.7	2.5	-1.6	-0.2	-0.9	0.3	-0.9	0.2
Arm fat percentage (right)	0.1	0.4	1.1	1.1	0.1	0.8	-0.4	0.6	0.0
Trunk fat-free mass	0.1	0.8	2.0	1.0	-1.0	0.3	0.6	1.4	0.5
Hip circumference	0.1	0.5	1.3	1.1	-0.4	0.6	0.1	1.1	0.1
Time employed in main current job	1.9	2.2	3.9	0.7	1.6	1.1	-1.2	-1.8	-2.0
Alcohol intake versus 10 years previously	0.2	0.4	1.1	-0.1	-1.1	0.3	0.7	-0.2	-0.7
Father’s age at death	0.7	0.9	1.9	-0.6	-0.4	-1.1	0.7	1.1	1.4
Worrier / anxious feelings	0.3	0.5	1.8	-0.2	1.3	-0.7	-0.4	0.1	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	5.2	0.5	-1.5	-0.4	1.3	2.3	0.6
Falls in the last year	0.2	0.2	0.4	0.6	0.4	0.6	-0.6	0.4	-0.4
Hair/balding pattern: Pattern 3	0.6	0.8	1.6	0.8	0.8	0.7	-0.4	-1.3	-1.2
Number of live births	1.1	1.5	3.1	1.3	0.8	1.7	-0.7	-1.0	-1.5
Forced expiratory volume in 1-second (FEV1)	1.4	4.9	9.0	-1.5	-3.0	-1.8	2.4	2.1	2.0
Pulse rate	0.4	0.6	1.9	-0.4	-0.6	-0.6	-0.0	1.4	0.9
Happiness	0.6	0.7	1.3	-1.1	-0.4	-1.1	0.9	-0.3	0.8
Noisy workplace	0.1	0.2	0.7	0.2	-0.2	0.3	0.2	0.1	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	1.0	0.8	0.5	-0.9	-0.4	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.9	0.0	-1.0	-0.1	0.2	-0.1	0.4
Mouth/teeth dental problems: Dentures	1.0	1.7	2.6	-1.3	-1.3	-1.4	1.6	1.0	1.2
Asthma	4.0	7.9	12.5	-2.1	-3.5	-2.5	2.9	2.8	2.9
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.6	1.7	-0.3	1.9	-0.1	-0.8	-1.7
Medication: Cholesterol lowering	0.4	0.7	1.1	-0.5	-0.7	-1.1	0.6	1.0	0.9
Depression (self-reported)	0.3	0.3	0.7	0.6	-0.1	0.8	0.1	0.7	-0.5
Medication: Lansoprazole	0.2	0.2	0.4	0.2	0.6	0.2	-0.6	-0.5	-0.4
Prospective memory result	1.7	2.1	4.2	1.0	1.9	1.2	-1.1	-1.0	-2.0
Lung cancer (father)	1.4	1.6	4.3	-2.1	-0.3	-1.6	0.9	-0.3	1.4
Illnesses of mother	3.8	4.7	6.3	1.8	2.2	2.3	-1.6	-2.4	-2.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.3	-0.5	-1.5	-0.5	1.1	1.0	0.7
Pulse wave Arterial Stiffness index	0.8	1.0	1.8	1.3	0.4	1.2	-1.0	-0.4	-1.1
Impedance of arm (left)	0.1	0.7	2.6	-1.6	0.0	-0.8	0.1	-1.0	-0.0
Arm fat mass (right)	0.1	0.6	1.5	1.2	-0.2	0.6	-0.2	1.2	0.3
Trunk predicted mass	0.1	0.8	2.1	1.0	-1.0	0.3	0.6	1.4	0.5
Standing height	0.1	1.5	2.1	-1.2	-1.3	-1.1	1.5	1.1	1.0
Length of working week for main job	0.7	0.8	1.6	1.3	0.7	1.2	-0.4	0.9	-0.5
Exposure to tobacco smoke at home	0.4	0.4	1.6	0.1	0.2	0.3	0.1	-1.3	-0.9
Breastfed as a baby	0.4	0.5	1.6	0.9	0.0	0.3	-0.3	1.2	-0.4
Tense / ‘highly strung’	1.7	2.8	4.1	-1.8	-1.9	-1.9	1.4	0.5	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.3	-1.2	-1.4	-1.4	1.0	1.2	1.5
Hair/balding pattern: Pattern 4	0.7	1.7	2.6	-1.1	-1.2	-1.1	1.6	1.6	1.2
Birth weight of first child	0.4	0.6	1.4	-1.2	-0.5	-1.1	0.6	0.6	0.6
Peak expiratory flow (PEF)	3.7	8.7	15.8	-1.6	-4.0	-2.0	3.0	3.8	2.4
Pulse wave reflection index	3.4	4.2	5.5	2.2	1.7	2.2	-1.8	-1.9	-2.4
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.4	-1.2	-1.1	-0.9	0.8	1.0	0.6
Loud music exposure frequency	0.6	0.7	2.0	-0.4	-0.8	-0.6	1.4	0.6	0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.7	0.2	0.5	-0.7	-0.5	-0.7
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.5	-0.1	-0.2	0.0	0.7	0.4	-0.2
Blood clot in the leg (DVT)	0.1	0.1	0.6	-0.0	0.3	-0.2	0.1	-0.8	-0.2
Medication: Paracetamol	3.3	5.4	6.6	-2.4	-2.5	-2.1	2.6	2.0	2.4
Headache pain in last month	0.1	0.2	0.6	0.7	-0.2	0.4	0.2	0.8	0.0
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	5.3	1.6	2.3	2.1	-1.6	-1.2	-1.7
Glaucoma (self-reported)	0.4	0.5	1.7	-0.2	1.1	0.1	-0.4	-1.3	0.1
Gout (self-reported)	0.4	0.6	1.1	-0.6	-1.0	-0.7	0.6	0.7	1.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.4	0.4	0.2
Medication: Amlodipine	0.4	0.6	1.4	-0.6	-1.2	-0.6	0.7	0.4	0.8
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.6	-0.6	-0.6	-1.3	1.3	1.6	1.5
Birth weight	0.3	0.8	2.5	1.6	0.3	0.8	-0.9	0.6	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.6	-0.0	0.6	0.1	-0.1	-0.8
High blood pressure (siblings)	1.8	2.7	5.5	-0.9	-2.4	-0.9	1.7	2.1	1.3
Forced vital capacity (FVC), Best measure	0.0	0.1	0.5	0.2	-0.7	0.3	0.3	0.3	-0.1
Body fat percentage	0.1	0.2	0.9	0.6	0.2	0.4	-0.2	0.9	0.1
Leg fat percentage (right)	0.2	0.8	3.5	0.1	-0.3	-0.4	0.5	1.9	1.1
Arm fat-free mass (right)	0.2	0.8	3.0	0.9	-0.7	0.2	0.4	1.7	0.5
Exposure to tobacco smoke outside home	0.9	1.3	4.0	-0.2	-0.8	-0.5	1.5	2.0	0.5
Comparative body size at age 10	0.3	1.0	2.2	1.0	1.5	0.7	-1.1	0.7	-0.5
Number of full brothers	0.2	0.2	0.7	-0.7	-0.0	-0.2	0.8	-0.0	0.1
Worry too long after embarrassment	1.4	2.4	5.3	0.4	1.9	1.2	-1.3	-2.3	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.9	0.1	-0.5	-0.5	0.3	1.7	0.3
Wheeze or whistling in the chest in last year	1.0	1.8	4.6	-0.3	-1.5	-0.8	1.6	2.1	0.7
Number of children fathered	0.5	0.5	1.1	-1.0	-0.4	-1.0	-0.2	0.0	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.5	-0.8	0.2	-0.0	-0.1	-1.2	-0.3
Age at first live birth	1.1	2.0	2.8	1.3	1.6	1.5	-1.0	-1.3	-1.7
Pulse wave peak to peak time	1.4	1.6	2.7	-1.7	-0.8	-1.5	1.3	0.5	1.4
Health satisfaction	0.2	0.2	0.4	-0.6	0.1	-0.6	0.4	0.3	0.5
Shortness of breath walking on level ground	0.2	0.3	0.8	0.5	-0.0	0.9	-0.1	-0.4	-0.6
Qualifications: College or University degree	1.8	5.6	9.0	2.2	1.7	2.7	-1.9	-2.5	-3.0
Eye problems/disorders: None of the above	0.2	0.3	1.2	0.0	-0.3	0.1	0.4	1.1	0.4
Mouth/teeth dental problems: Loose teeth	4.6	5.5	7.1	2.0	2.6	2.6	-2.0	-2.0	-2.7
Emphysema/chronic bronchitis	0.3	0.4	0.8	-0.6	-0.4	-0.7	0.6	0.9	0.5
Medication for pain relief, constipation, heartburn	0.6	1.1	1.9	1.0	1.4	0.7	-1.3	-0.2	-1.1
Neck or shoulder pain in last month	1.4	2.0	4.3	-1.2	-1.0	-1.5	1.3	2.1	1.2
Medication: Blood pressure	2.0	3.5	6.9	-1.8	-2.6	-2.2	1.6	0.8	1.7
Angina (self-reported)	0.3	0.4	1.0	0.4	1.0	0.1	-0.5	-0.2	-0.9
Migraine (self-reported)	0.3	0.3	0.8	-0.2	-0.3	-0.6	0.1	0.8	0.9
Medication: Ibuprofen	0.7	0.8	1.9	1.2	-0.5	1.4	0.2	-0.1	-1.0
Medication: Allopurinol	0.9	1.1	2.1	-1.4	-0.9	-1.4	0.4	0.5	1.3
Medication: Omeprazole	0.6	0.7	2.0	-1.4	-0.1	-1.0	0.4	-0.9	-0.0
Medication: Seretide 50 evohaler	2.1	2.4	5.3	-1.7	-0.8	-1.9	1.0	1.3	2.3
Mean time to correctly identify matches	0.4	0.8	1.1	0.9	0.9	0.7	-1.0	-0.8	-1.1
Heart disease (mother)	1.7	2.1	3.2	-1.4	-0.8	-1.5	1.4	1.8	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	-0.8	-1.1	-0.8	0.5	0.3	0.7
Whole body fat mass	0.1	0.5	1.8	0.9	-0.0	0.5	-0.0	1.4	0.3
Leg fat mass (right)	0.2	0.7	2.9	0.7	-0.1	0.2	0.2	1.7	0.7
Arm predicted mass (right)	0.1	0.6	1.7	1.1	-0.4	0.4	0.1	1.3	0.2
Pulse rate, automated reading	1.3	4.1	10.1	-1.4	-1.9	-1.6	1.6	3.2	1.9
Alcohol intake frequency.	2.6	6.1	13.6	-1.8	-3.7	-1.7	2.7	2.6	1.8
Comparative height size at age 10	0.1	0.3	0.5	-0.7	-0.3	-0.6	0.4	0.6	0.7
Number of full sisters	0.2	0.3	0.5	0.7	0.4	0.7	-0.4	0.3	-0.5
Suffer from ‘nerves’	5.9	9.2	14.5	-2.5	-3.0	-3.1	2.4	3.2	3.8
Overall health rating	2.8	5.9	7.9	-1.5	-2.7	-2.4	2.2	2.8	2.8
Chest pain or discomfort	0.4	0.6	1.3	-0.1	-0.9	-0.4	1.1	1.0	0.4
Had major operations	0.0	0.1	0.2	0.0	-0.1	0.2	0.3	0.5	-0.2
Age at last live birth	3.2	4.7	6.1	2.2	2.3	2.5	-1.6	-1.9	-2.4
Family relationship satisfaction	0.2	0.3	0.8	-0.2	-0.1	-0.1	0.7	-0.9	-0.6
Leg pain on walking	0.2	0.2	0.8	-0.2	-0.0	0.0	0.9	0.7	-0.0
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	4.2	-1.3	-2.1	-1.6	1.7	1.7	1.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.0	-0.2	-0.5	-0.7	0.3	1.7	1.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.5	0.8	1.2	1.2	-1.0	-1.0	-1.2
Medication: Aspirin	0.3	0.4	0.9	0.2	0.8	0.0	-0.8	-1.0	-0.1
Supplements: Vitamin C	0.2	0.3	0.8	0.1	0.6	0.2	0.7	0.9	-0.1
Knee pain experienced in last month	0.1	0.2	0.5	0.7	-0.5	-0.0	0.4	0.3	-0.1
Hypertension (Self-reported)	1.0	2.8	6.7	-0.9	-2.6	-1.3	1.7	1.4	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	1.9	1.1	1.3	1.3	-1.2	-0.8	-1.4
Illnesses of father: Heart disease	0.3	0.4	1.3	-0.1	-0.7	-0.3	1.1	0.7	0.0
Illnesses of siblings: Diabetes	4.0	4.9	7.3	-1.7	-2.4	-2.0	2.0	2.7	2.4
Smoking status: Previous	0.1	0.2	0.4	-0.3	0.6	0.4	-0.0	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.7	-0.4	-1.0	-0.3	0.6	1.3	0.9
Whole body fat-free mass	0.1	0.7	2.0	1.4	-0.5	0.7	0.1	1.2	0.1
Leg fat-free mass (right)	0.2	0.9	3.0	1.7	0.1	1.3	-0.5	0.5	-0.5
Arm fat percentage (left)	0.1	0.5	1.3	1.2	0.4	0.8	-0.6	0.5	-0.2
Average weekly red wine intake	0.9	1.3	4.5	0.1	0.9	0.6	-0.8	-2.1	-1.3
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.6	-0.7	-0.7	-0.9	1.4	1.5	1.6
Mood swings	0.1	0.2	0.4	-0.2	0.1	-0.4	0.6	-0.5	0.2
Loneliness, isolation	0.2	0.2	0.4	-0.2	0.6	-0.7	0.3	0.2	0.6
Long-standing illness, disability or infirmity	2.0	3.0	5.1	-1.1	-2.1	-1.6	1.7	2.3	1.6
Ever had bowel cancer screening	0.7	0.8	1.7	-1.3	-0.7	-0.8	1.0	0.6	0.8
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.6	0.0	-0.6	0.0	-0.4	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.7	0.7	0.9	0.7	-0.6	0.4	-0.8
Friendships satisfaction	0.3	0.4	1.0	-1.0	0.6	-0.6	0.5	-0.6	0.1
Qualifications: nursing, teaching	0.7	1.1	2.9	1.7	-0.3	1.5	-0.6	0.2	-1.0
Commuting to job workplace: Walk	3.3	3.5	4.5	-1.4	-1.9	-2.1	1.9	2.1	1.8
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.1	-0.0	-0.2	0.0	0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	5.1	2.1	2.3	1.9	-1.0	0.2	-1.3
Medication for cholesterol	0.1	0.2	0.9	-0.2	0.9	-0.3	-0.3	0.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	0.4	0.7	0.6	-0.6	-0.5	-0.8
Back pain experienced in last month	5.2	7.6	13.9	-2.4	-3.7	-2.4	2.6	2.6	2.4
Mineral and other dietary supplements	0.1	0.1	0.3	-0.1	-0.3	0.4	-0.5	0.5	0.1
Breast cancer (self-reported)	0.1	0.1	0.2	-0.5	0.3	-0.2	-0.2	-0.4	-0.0
Asthma (self-reported)	3.4	6.8	10.8	-1.9	-3.3	-2.2	2.7	2.6	2.7
Osteoporosis (self-reported)	2.3	2.8	4.1	-1.7	-0.8	-1.6	1.8	1.9	2.0
Osteoarthritis (self-reported)	1.6	2.0	4.3	0.9	1.4	1.3	-1.2	-2.1	-1.4
Medication: Aspirin	0.2	0.2	0.8	-0.0	0.5	-0.1	-0.6	-0.9	0.1
Medication: Gliclazide	0.1	0.1	0.2	-0.2	0.2	-0.2	-0.2	0.5	0.3
Illnesses of father: None of the above (group 1)	0.5	0.7	1.3	0.2	1.1	0.7	-1.0	-0.9	-0.5
Smoking status: Current	2.8	4.5	6.7	2.3	1.9	2.3	-1.1	-2.0	-2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.1	-1.1	-0.9	-0.9	0.6	0.7	0.8
Whole body water mass	0.1	0.7	1.8	1.3	-0.6	0.7	0.1	1.2	0.1
Leg predicted mass (right)	0.2	0.9	2.9	1.7	0.1	1.2	-0.5	0.5	-0.4
Arm fat mass (left)	0.2	0.7	1.9	1.4	0.2	0.8	-0.4	1.1	0.1
Number of self-reported non-cancer illnesses	2.0	3.4	7.9	-1.0	-2.8	-1.2	2.2	1.7	1.5
Average weekly champagne plus white wine intake	1.9	2.6	4.2	1.0	1.9	1.3	-1.3	-1.9	-2.1
Miserableness	0.1	0.2	0.6	0.2	-0.0	0.2	0.5	0.8	-0.5
Guilty feelings	1.2	1.8	6.7	-0.4	1.1	0.2	-1.2	-2.6	-1.1
Wears glasses or contact lenses	1.6	1.8	4.4	-2.1	-0.7	-2.0	1.0	-0.0	1.1
Ever taken oral contraceptive pill	0.3	0.4	0.9	0.9	0.9	0.4	-0.5	-0.5	-0.0
Hearing aid user	2.6	2.9	6.4	-2.5	-1.4	-2.1	1.2	0.4	1.8
Mother’s age at death	0.2	0.3	0.9	0.7	-0.1	0.2	-0.0	0.9	-0.1
Financial situation satisfaction	0.2	0.3	0.7	-0.5	-0.4	-0.5	0.4	0.8	0.2
Tinnitus: Yes, now most or all of the time	2.8	3.3	5.5	-1.6	-1.8	-2.4	0.8	1.7	2.2
Commuting to job workplace: Public transport	1.0	1.1	1.4	1.1	1.0	1.1	-0.9	-1.2	-1.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.1	-1.0	-0.5	-0.9	0.8	-0.6	1.0
Medication: Blood pressure	0.2	0.3	0.5	0.6	-0.7	0.5	0.7	-0.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	0.5	0.2	1.1	0.3	-0.0	-0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.4	-0.9	-0.8	-1.5	1.6	0.3	1.2
High cholesterol (Self-reported)	0.8	1.4	2.3	-0.7	-1.5	-0.9	1.4	1.3	1.0
Medication: Bendroflumethiazide	0.2	0.3	1.0	-0.1	-1.0	-0.1	0.5	0.6	0.1
Medication: Paracetamol	5.4	8.3	10.2	-3.1	-2.7	-2.9	3.2	2.3	3.0
Medication: Lisinopril	0.1	0.1	0.2	0.3	-0.5	0.1	-0.3	-0.5	-0.4
Medication: Atorvastatin	1.3	1.7	3.1	-1.4	-1.3	-1.8	1.0	0.8	1.2
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.7	0.0	0.8	-0.6	-0.9	-0.4
Alcohol drinker status: Never	0.3	0.3	0.6	0.6	-0.8	0.7	0.4	0.1	-0.6
Ever smoked	3.1	5.4	8.9	1.7	2.6	2.5	-0.9	-3.0	-2.7
Basal metabolic rate	0.1	0.7	1.8	1.3	-0.5	0.6	0.1	1.4	0.2
Leg fat percentage (left)	0.2	0.6	2.7	0.5	-0.0	0.0	0.2	1.6	0.6
Arm fat-free mass (left)	0.2	1.0	3.0	1.3	-0.7	0.5	0.4	1.7	0.4
Number of operations (self-reported)	0.6	0.9	2.0	0.5	1.4	0.8	-0.7	-1.0	-0.8
Average weekly beer plus cider intake	2.8	4.1	8.7	3.0	1.4	2.4	-1.7	-0.8	-2.1
Irritability	0.7	1.1	1.9	-1.2	-0.3	-1.4	1.2	0.1	1.3
Risk taking	0.8	1.1	5.2	0.6	0.6	0.7	-0.1	-2.3	-0.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.4	0.8	-0.3	0.6	-0.3	0.0
Fractured/broken bones in last 5 years	0.3	0.4	1.0	-1.0	0.4	0.3	0.5	-0.9	-0.5
Age started oral contraceptive pill	0.2	0.3	1.0	-0.3	0.6	-0.2	-0.5	-1.0	0.2
Diastolic blood pressure, automated reading	2.3	7.1	8.0	-2.6	-2.8	-2.7	2.4	2.7	2.7
Ever depressed for a whole week	0.6	0.7	1.3	-1.2	-0.1	-1.1	1.1	0.7	0.7
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.0	-0.4	0.1	0.2	0.2	-0.5
Commuting to job workplace: Cycle	4.0	4.9	12.2	0.8	2.0	1.6	-1.7	-3.5	-2.6
Myopia	1.0	1.4	1.9	1.1	0.9	1.2	-1.4	-1.2	-1.3
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.1	0.5	2.0	0.8	-1.3	-1.1	-0.8
Cholesterol lowering medication	0.5	0.7	2.4	-0.7	-1.6	-0.6	0.8	-0.0	0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	-0.9	-0.1	-0.6	0.0	-1.1	-0.1
Pain experienced in last month	0.3	0.6	1.3	0.8	1.1	0.6	-0.9	-0.6	-0.2
Supplements: Calcium	0.4	0.4	1.1	1.1	0.1	0.7	-0.5	0.7	-0.2
Basal cell carcinoma (self-reported)	0.5	0.5	1.4	1.2	0.8	0.8	0.4	0.4	-0.5
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	-0.1	0.1	-0.2	0.3	-0.3	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.1	0.1	-0.4	0.3	-0.4	0.0
Heart disease (siblings)	0.3	0.4	0.9	0.5	0.2	1.0	-0.1	-0.5	-0.8
Alcohol drinker status: Previous	1.0	1.1	1.9	-0.7	-1.2	-0.7	1.0	1.4	1.1
Pack years of smoking	0.3	0.4	0.8	-0.2	-0.6	-0.5	0.3	0.8	0.9
Impedance of whole body	0.2	1.2	4.6	-2.1	-0.4	-1.3	0.8	-0.2	0.5
Leg fat mass (left)	0.2	0.7	2.6	1.0	0.1	0.4	-0.0	1.6	0.4
Arm predicted mass (left)	0.2	0.9	2.7	1.3	-0.7	0.6	0.2	1.6	0.3