Hub : Genes

NMT2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0260	7.4e-03	0.023	0.032	0.036	0.033	0.030	6.8e-04	8.0e-05	3.2e-05	6.1e-05	1.4e-04
2	GTEx	Artery Tibial	0.2758	0.0638	1.3e-05	0.074	NA	0.062	NA	0.082	1.8e-06	NA	1.3e-05	NA	5.6e-07
3	GTEx	Nerve Tibial	0.2292	0.0681	7.2e-04	0.137	NA	0.139	NA	0.128	6.0e-10	NA	4.4e-10	NA	2.5e-09
4	GTEx	Skin Not Sun Exposed Suprapubic	0.2660	0.0850	3.0e-03	-0.005	NA	0.003	NA	-0.001	9.4e-01	NA	2.1e-01	NA	3.5e-01
5	METSIM	Adipose	0.1596	0.0384	1.0e-06	0.079	0.062	0.086	0.103	0.104	7.0e-12	1.2e-09	8.5e-13	3.6e-15	2.8e-15
6	NTR	Blood	0.1223	0.0237	1.0e-09	0.057	0.044	0.077	0.060	0.077	6.5e-18	5.6e-14	1.3e-23	8.8e-19	1.1e-23
7	ROSMAP	Brain Pre-frontal Cortex	0.1044	0.0287	2.2e-05	0.032	0.036	0.056	0.036	0.047	5.1e-05	1.8e-05	1.0e-07	1.6e-05	1.1e-06
8	YFS	Blood	0.3767	0.0371	0.0e+00	0.165	0.208	0.245	0.274	0.232	1.8e-51	3.5e-66	3.5e-79	6.0e-90	1.7e-74
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0819	0.0308	1.8e-04	0.035	0.039	0.062	NA	0.058	7.5e-05	3.1e-05	1.5e-07	NA	4.1e-07
10	TCGA	Lung Squamous Cell Carcinoma	0.0696	0.0310	3.3e-03	0.040	0.022	0.015	NA	0.032	2.2e-05	1.5e-03	7.0e-03	NA	1.2e-04
11	TCGA	Pheochromocytoma and Paraganglioma	0.1220	0.0530	1.3e-03	0.134	0.031	0.042	NA	0.074	5.5e-06	2.1e-02	9.1e-03	NA	6.7e-04
12	TCGA	Prostate Adenocarcinoma	0.0907	0.0397	3.0e-03	0.051	0.032	0.034	NA	0.039	4.6e-06	2.6e-04	1.7e-04	NA	5.2e-05
13	TCGA	Thyroid Carcinoma	0.1150	0.0390	3.0e-05	0.031	0.059	0.098	NA	0.089	5.3e-04	1.9e-06	8.3e-10	NA	5.2e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.3	0.4	2.4	-1.5	-0.7	0.3	-0.3	-0.5	0.3	-0.2	0.2	-0.0	-1.1	-0.6	-0.7	-0.1
Bipolar Disorder or Schizophrenia	0.8	2.0	8.5	-2.9	-1.1	-1.2	-0.6	0.6	0.4	-1.2	-0.4	0.3	-2.4	-1.1	-2.1	-0.2
Depressed Affect (Nagel 2018)	0.9	1.9	5.4	-0.3	-1.7	-1.7	0.7	2.2	0.7	-0.8	0.1	0.5	-1.4	-2.1	-2.3	-0.7
Depression (Nagel 2018)	0.3	0.4	2.4	0.4	-1.1	-0.1	0.7	0.5	0.2	-0.1	-0.5	-0.4	0.0	-0.8	-1.5	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.8	-0.2	0.1	0.3	0.4	-1.7	-0.9	0.2	0.5	-1.6	0.6	0.7	0.9	-0.6
Neuroticism (Nagel 2018)	1.7	4.0	10.9	-0.5	-2.9	-2.8	0.3	-0.2	-0.7	-1.9	-1.0	-1.7	-2.0	-2.3	-3.3	-2.6
Schizophrenia (2018)	0.9	1.9	5.6	-2.4	-0.8	-1.8	-0.5	1.1	0.6	-1.4	-0.6	0.4	-2.2	-1.0	-2.1	-0.2
Schizophrenia vs Biploar Disorder	0.9	1.2	3.5	-0.6	-1.1	-1.9	-0.3	0.1	-0.3	-1.4	-1.1	-0.4	-0.9	-1.0	-1.8	-1.3
Worry (Nagel 2018)	1.7	3.5	8.9	-1.2	-2.3	-2.7	-0.3	-0.6	-1.3	-2.1	-0.9	-2.5	-1.9	-1.2	-3.0	-2.2
Alzheimer’s Disease (in mother)	0.3	0.3	1.3	0.4	0.4	0.8	-0.0	0.1	-0.7	0.5	-0.8	-0.3	1.1	0.5	0.2	0.1
Alzheimer’s Disease (in father)	1.6	1.7	5.7	-1.3	-1.4	-0.9	0.4	0.6	1.9	-0.9	2.4	0.2	-1.1	-1.9	-1.4	-1.0
Alzheimer’s Disease (including proxy)	0.3	0.4	1.2	-1.1	-0.8	0.0	-0.1	-0.0	0.1	-0.5	0.7	-0.5	0.0	-1.0	-0.6	-0.9
Crohns Disease (2017)	0.1	0.2	1.0	-0.5	0.1	0.6	-0.3	0.5	0.4	-0.1	1.0	-0.4	0.1	-0.2	0.2	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	1.3	0.1	0.1	0.4	-0.5	-0.5	-0.4	-0.4	0.0	-1.1	-0.3	0.2	-0.0	0.0
Ulcerative Colitis (UC)	0.2	0.3	1.8	0.2	-0.2	-0.1	0.0	-0.8	-0.3	-0.8	-0.3	-1.3	-0.9	-0.0	-0.4	-0.1
Major Depression (MDD)	0.6	0.8	1.9	-1.1	-1.0	-0.8	-0.2	0.2	-0.9	-1.1	-0.7	-0.7	-1.4	-0.8	-1.0	-0.9
Reaction Time	0.5	0.9	6.1	0.8	-0.5	-0.9	0.8	0.4	1.4	-0.4	2.5	0.4	0.4	-0.9	-0.1	0.1
Verbal and Numeric Reasoning (VNR)	0.6	1.5	4.3	1.7	1.0	0.6	-0.3	-1.9	-1.5	0.9	0.2	-1.4	0.8	1.5	2.1	-0.1
Breast Cancer	0.3	0.6	3.6	0.4	0.7	-0.0	0.7	-0.4	0.3	0.1	1.3	-0.5	1.9	0.7	0.8	-0.4
Ovarian Cancer	0.5	0.7	2.1	-0.8	-0.8	-1.0	-0.6	-0.7	0.0	-0.9	-0.2	-0.7	-1.5	-0.6	-1.3	-0.9
Prostate Cancer	0.1	0.2	0.6	0.0	0.1	-0.4	-0.2	0.5	0.6	0.8	0.8	-0.3	-0.1	0.3	-0.3	-0.1
Age at First Birth	0.8	1.1	4.6	-0.3	1.9	0.8	-0.4	0.7	-0.3	-0.0	0.1	0.3	0.1	2.2	1.0	1.8
Bipolar Disorder (2011)	0.3	0.3	1.4	-1.0	-0.9	0.3	0.0	0.8	1.2	-0.2	0.6	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	2.3	0.4	-0.4	0.2	0.4	-1.4	-1.5	0.6	-1.0	-1.5	1.0	0.1	0.4	-1.5
Coronary Artery Disease (CAD)	0.8	0.9	3.7	1.3	-1.4	0.1	1.5	-0.0	-0.1	0.7	-0.2	0.1	0.9	-1.9	-0.5	-0.5
Crohns Disease (2012)	0.2	0.3	1.1	0.8	0.4	1.1	-0.7	-0.1	-0.3	0.9	-0.3	0.0	0.5	0.5	0.6	0.5
Mean Putamen Volume	0.2	0.2	0.8	-0.2	0.0	-0.4	0.6	0.8	-0.4	-0.4	0.4	0.1	0.0	0.1	-0.1	0.9
Fasting Glucose	0.6	0.8	2.2	0.5	0.5	1.3	0.2	1.3	1.5	0.7	1.2	1.1	0.5	-0.1	0.2	0.5
HbA1C	0.9	1.0	3.9	0.7	0.4	0.4	-0.4	1.4	0.8	1.1	0.8	1.9	-0.1	0.0	-0.2	2.0
HDL Cholesterol	0.7	1.1	3.0	0.5	-1.4	-1.0	1.1	-0.1	-0.7	-0.5	-1.5	-0.7	-0.6	-1.6	-0.4	-1.7
LDL Cholesterol	0.2	0.3	1.6	-0.7	-0.5	-0.5	-0.2	-0.6	-0.2	-0.2	-1.3	-0.0	0.1	-0.3	-0.1	-0.4
Lupus	0.9	1.3	3.2	-0.6	-1.7	-1.2	0.5	-0.8	-1.3	-0.6	-1.7	-0.8	-1.0	-1.0	-1.8	-0.6
Neuroticism (2016)	0.6	0.9	2.7	0.0	-1.5	-1.3	0.9	0.1	0.7	-0.6	-0.4	-0.4	-0.4	-1.6	-1.4	-0.9
Primary Biliary Cirrhosis	0.3	0.4	1.5	-0.1	-0.6	-0.8	-0.5	1.2	0.5	-0.1	0.4	0.6	-0.3	-0.9	-0.9	0.1
Rheumatoid Arthritis	0.4	0.6	2.0	-0.9	0.5	-0.3	-0.9	0.7	1.4	-0.6	1.4	0.5	-0.7	0.4	-0.0	0.4
Schizophrenia (2014)	1.6	3.5	16.5	-3.4	-1.0	-1.7	-1.0	1.7	1.0	-1.3	-0.1	0.7	-4.1	-1.0	-2.4	-0.2
Triglycerides	0.7	1.2	4.4	1.0	0.3	0.6	0.9	-2.1	-1.3	0.6	-1.2	-0.9	1.6	0.7	1.1	0.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.2	0.5	0.3	0.1	-0.2	0.4	1.3	0.5	1.8	1.3	1.3	-0.4	0.0	0.2
Ulcerative Colitis	0.3	0.4	1.9	0.1	-0.6	-0.0	0.6	-0.5	-0.0	-0.6	-0.2	-1.4	-1.1	-0.7	-0.5	-0.6
Blood Eosinophil Count	0.4	2.8	7.9	1.1	1.9	2.1	0.3	1.7	2.0	1.1	2.1	2.0	0.8	1.2	0.7	2.8
Blood Platelet Count	0.2	2.7	5.8	2.3	2.1	2.4	-0.2	-0.5	0.7	2.2	1.6	0.3	0.4	2.1	2.3	1.4
Blood Red Count	0.1	1.2	3.8	0.3	-1.4	-0.8	0.5	-1.7	-1.8	0.1	-0.6	-1.9	1.0	-0.7	0.0	-1.2
Blood White Count	0.2	1.3	6.2	2.0	-0.2	0.1	0.9	-2.5	-0.5	0.4	1.1	-0.5	1.8	0.5	0.3	-0.0
Heel T-Score	0.6	4.4	26.1	-0.9	0.4	-0.9	-2.0	-5.1	-2.8	-1.7	-2.0	-1.9	0.6	2.0	1.0	-1.2
BMI	0.8	4.5	18.6	2.2	-0.4	0.0	2.1	-4.3	-3.2	0.4	-2.7	-1.8	2.6	0.7	1.1	-1.1
Height	0.8	15.8	42.1	-4.2	-5.8	-5.6	2.3	0.6	0.0	-4.9	-0.8	-1.0	-1.7	-6.5	-5.4	-4.1
Waist Hip Ratio (WHR)	0.3	1.2	6.2	0.1	1.1	0.7	-0.5	-2.5	-0.3	-0.1	-0.4	0.1	0.3	1.6	1.3	1.5
Systolic Blood Pressure	0.4	1.9	5.3	-0.6	1.5	1.1	-2.3	-1.1	-1.7	0.2	-1.9	-0.3	-1.4	2.1	1.1	0.3
Smoking Status	0.7	1.7	5.2	-0.9	-1.7	-1.4	0.3	0.5	1.2	-1.5	1.1	-0.1	-1.6	-1.8	-2.3	-0.8
Allergy or Eczema	0.1	0.3	1.2	-0.8	0.4	0.0	-1.1	-0.1	-0.3	-0.5	-0.2	-0.3	-0.7	0.6	-0.4	-0.6
Cardiovascular Disease	0.4	1.5	5.8	-0.9	0.5	-0.0	-0.9	-2.4	-1.6	-1.1	-2.4	-0.0	-0.4	1.4	0.1	0.3
Hypothyroidism (self reported)	2.1	4.9	11.4	0.8	2.4	3.2	0.2	3.0	2.4	1.6	2.6	3.4	0.8	0.6	2.2	2.4
Respiratory disease	0.6	1.3	5.6	1.1	0.6	0.4	0.9	-0.7	1.3	0.3	2.4	-0.2	1.8	0.4	1.7	0.4
Type 2 Diabetes (T2D) (2018)	0.6	1.1	7.6	-0.3	-0.3	0.6	2.8	-0.7	0.3	0.6	0.8	0.1	1.4	-0.7	1.0	0.9
Lung FEV1/FVC ratio	0.2	0.9	4.3	-2.1	-0.9	-0.6	1.1	-1.2	-0.1	-1.8	-0.4	-0.4	-0.2	-0.6	-0.6	-0.1
Lung FVC	0.3	1.5	4.8	-1.8	1.3	0.7	-1.7	2.2	1.1	0.3	1.1	1.2	-0.6	1.0	-0.0	1.1
Neuroticism	2.9	7.0	19.6	-1.4	-3.9	-3.5	0.5	0.2	-0.8	-2.2	-1.3	-2.0	-3.1	-3.3	-4.4	-3.1
Chronotype (morning person)	0.2	0.4	1.0	0.3	-0.7	-0.5	0.3	-0.6	0.8	0.2	0.1	0.7	1.0	-1.0	-0.7	-0.3
Hair Pigment	0.1	1.7	6.6	1.9	1.5	1.5	0.5	-0.5	0.0	1.1	1.5	-0.1	1.4	1.1	2.6	0.6
Tanning	0.1	0.9	2.4	-1.1	-0.9	0.3	-0.5	1.1	-0.2	0.2	-1.3	1.4	-0.8	-1.6	-0.9	-0.2
Hand grip strength (left)	1.2	3.1	7.3	-2.7	-1.8	-2.3	0.1	0.6	-0.4	-2.6	-1.7	-0.2	-1.6	-2.5	-2.0	-1.1
Number of treatments/medications taken	1.3	2.4	5.7	0.1	2.4	1.9	-0.9	1.2	1.4	0.4	1.4	1.5	1.2	2.3	1.1	2.3
Average weekly spirits intake	1.3	1.6	5.5	-0.8	-0.4	-0.7	-0.9	-2.4	-2.0	-0.7	-1.6	-1.6	-1.0	0.6	-0.3	-1.3
Sensitivity / hurt feelings	1.9	3.3	10.5	-0.7	-2.7	-2.8	0.1	0.9	1.0	-1.5	0.3	-0.3	-1.3	-2.7	-3.2	-1.7
Frequency of depressed mood in last 2 weeks	1.0	1.5	4.2	-1.4	-1.8	-0.6	1.8	0.7	1.1	-1.0	0.5	-0.4	-0.3	-1.6	-2.1	-0.1
Hearing difficulty/problems: Yes	0.9	1.3	4.5	-0.4	-1.2	-1.2	-0.5	-1.3	-0.6	-0.3	-1.0	-1.9	-1.1	-0.6	-0.9	-2.1
Relative age of first facial hair	0.4	0.9	5.3	-0.2	0.6	-0.2	-2.3	-1.2	-0.0	-0.1	-0.3	-0.2	-0.6	1.6	-0.8	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	0.5	0.2	0.7	0.3	0.6	0.1	0.2	0.5	0.8	0.4	-0.2	0.8	0.6
Ever used hormone-replacement therapy (HRT)	0.8	1.1	4.7	1.3	1.0	0.6	0.1	0.6	1.5	0.8	2.2	1.0	0.7	0.9	0.5	0.7
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	0.4	0.3	0.6	-0.6	-0.8	0.2	0.4	0.2	-1.1	-0.5	0.7	0.2	-1.1
Systolic blood pressure, automated reading	0.5	1.6	3.2	0.6	0.9	1.0	-0.9	-1.7	-1.8	1.2	-1.4	-1.1	-0.9	1.7	1.6	-0.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.4	-0.2	1.0	0.8	-1.0	-0.4	-0.9	-0.1	-1.5	-0.1	0.0	1.3	0.3	0.3
Angina	0.3	0.4	2.1	-0.2	-0.3	0.2	0.7	0.7	0.3	-0.5	0.4	-0.6	-1.5	-0.4	-0.0	-0.5
Medication for hormone replacement therapy	0.7	0.7	3.2	1.8	0.4	0.7	0.6	0.5	0.9	0.6	1.2	0.4	1.3	0.3	0.1	0.6
Vitamin and mineral supplements	1.2	1.7	10.6	0.3	-0.6	0.3	0.5	-1.7	-2.6	0.2	-3.2	-0.5	0.4	-0.3	0.4	-0.6
Supplements: Zinc	0.4	0.4	2.0	0.9	0.6	-0.1	0.2	0.1	0.4	0.4	1.4	-1.1	0.5	0.6	0.2	-0.3
Medication: Co-codamol	1.8	2.1	8.9	0.7	2.4	0.5	-2.4	-0.2	0.5	0.5	1.0	0.3	-0.0	3.0	1.3	1.6
Medication: Metformin	0.6	0.9	3.8	-0.5	-0.8	-0.3	1.9	-1.6	-0.7	0.0	-0.7	-1.0	0.8	-0.6	0.4	-0.7
Diabetes (father)	0.8	0.9	2.7	0.5	-1.0	-1.0	0.3	-1.3	-1.6	-0.0	-1.4	-1.1	-1.0	-0.6	0.1	-0.8
Diabetes (mother)	0.5	0.7	1.7	0.7	1.1	1.2	-0.3	0.4	0.8	0.9	0.5	0.9	-0.0	1.0	0.7	1.3
Severe depression (siblings)	0.9	1.0	3.2	-0.7	-0.5	-0.4	-0.0	-0.7	-1.1	-1.7	-0.7	-1.8	-1.2	0.1	-1.3	-0.7
Pack years adult smoking proportion	0.1	0.2	0.7	0.8	0.2	0.1	-0.3	-0.7	0.5	-0.1	0.5	-0.3	0.1	0.6	-0.8	0.1
Impedance of leg (right)	0.6	2.7	6.3	-1.6	1.0	1.1	-2.2	2.2	2.5	0.4	1.7	2.0	-1.8	0.3	-0.8	1.8
Leg fat-free mass (left)	0.4	2.3	5.3	-0.0	-1.6	-1.8	2.1	-1.5	-2.3	-1.3	-2.3	-1.0	1.0	-1.3	-0.6	-1.0
Trunk fat percentage	1.5	6.2	13.3	3.6	2.5	2.4	0.9	-3.1	-2.1	2.7	-1.3	-0.4	2.9	3.0	3.6	0.9
Hand grip strength (right)	1.3	3.4	8.5	-2.7	-2.1	-2.1	-0.5	0.3	-0.3	-2.4	-1.6	-0.5	-1.8	-2.4	-2.9	-1.3
Townsend deprivation index at recruitment	0.2	0.3	1.3	-0.3	-0.0	-0.5	-0.2	-1.1	-0.4	-0.5	0.3	-1.0	0.1	0.6	0.2	-0.1
Current tobacco smoking	0.7	1.1	4.0	1.4	0.3	0.6	0.3	2.0	1.4	0.1	1.3	1.2	-1.0	-0.3	-0.6	1.0
Average weekly fortified wine intake	1.8	2.1	6.8	-0.6	-1.5	-0.9	0.3	-1.4	-2.6	-2.1	-1.3	-1.9	0.1	-1.1	-0.2	-2.1
Maternal smoking around birth	2.1	3.0	10.4	-2.1	-1.7	-2.3	-0.0	0.7	-0.6	-3.2	-1.5	-0.8	-1.7	-1.4	-2.6	-0.9
Fed-up feelings	1.6	2.9	7.9	-1.9	-2.6	-2.2	0.3	1.2	0.3	-1.3	-0.3	0.3	-1.8	-2.8	-2.7	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	4.5	-1.4	-1.2	-1.1	0.3	0.1	0.5	-1.4	0.2	-0.7	-0.2	-0.6	-2.1	-0.8
Relative age voice broke	0.0	0.0	0.2	0.2	0.0	-0.0	-0.1	-0.1	0.3	0.3	0.4	-0.3	0.1	0.2	-0.1	-0.0
Taking other prescription medications	0.4	0.7	3.1	0.0	0.5	0.1	-0.7	1.3	0.7	-0.7	0.7	0.8	-0.6	0.5	-0.5	1.8
Age when periods started (menarche)	1.0	2.5	6.4	0.8	2.3	1.8	-0.9	0.9	1.8	1.0	1.1	1.9	0.2	1.8	1.6	2.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	5.0	1.2	1.7	1.5	-1.4	-0.5	0.2	1.1	0.7	0.3	0.5	2.2	0.8	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	7.4	0.2	0.6	0.0	-1.6	-2.2	-2.7	-0.6	-2.5	-1.0	0.2	1.2	1.2	-0.3
Tinnitus: Yes, but not now, but have in the past	1.4	1.4	8.5	-1.7	-0.3	-0.5	-1.9	0.7	-0.2	-0.5	-1.1	0.2	-2.9	-0.1	-1.2	0.2
Qualifications: CSEs or equivalent	0.9	1.2	5.3	-2.3	-1.0	-1.2	-0.1	-0.2	-0.6	-1.5	-1.0	-0.9	-0.8	-0.7	-1.4	-0.4
Serious illness, injury or assault to yourself	2.5	3.1	6.5	2.5	1.8	1.7	0.5	1.2	1.4	2.3	1.0	1.8	2.0	1.3	1.2	2.6
High blood pressure	0.5	1.3	3.6	-0.0	1.4	1.0	-0.6	-1.4	-1.6	-0.1	-1.4	-0.5	-0.6	1.9	1.5	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	-0.6	0.3	-0.1	-0.4	0.6	0.1	-0.6	0.4	-0.2	-0.2	0.2	-0.4	0.3
Multivitamins +/- minerals	1.1	1.4	9.6	-0.2	0.5	-0.3	0.2	1.1	2.6	-0.1	3.1	0.1	-0.2	0.3	-0.2	0.7
Stomach or abdominal pain in last month	0.5	0.7	4.7	-1.0	-0.4	0.1	-0.4	-0.1	-1.3	0.2	-2.2	0.8	-0.0	-0.5	0.3	-0.1
Supplements: Glucosamine	1.6	2.1	14.8	-0.3	0.5	0.9	0.1	1.6	2.9	0.2	3.9	0.3	0.7	-0.1	0.4	0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.2	-1.1	0.8	0.2	0.8	-0.1	0.8	-1.1	1.1	-0.4	-0.6	0.6	-0.4	0.5
Medication: Atenolol	0.6	0.8	5.4	0.4	-0.1	0.4	0.2	-1.1	-1.3	0.1	-2.3	-0.7	-0.2	0.4	-0.3	-0.6
Medication: Levothyroxine sodium	0.6	1.0	3.7	0.3	0.6	1.7	0.8	0.8	0.6	1.3	0.4	1.9	0.1	-0.4	1.4	0.7
Sitting height	0.8	6.0	14.4	-2.8	-3.1	-3.5	0.9	1.7	0.3	-3.0	-0.5	-0.5	-1.8	-3.7	-3.8	-1.7
Chronic bronchitis/emphysema (father)	2.0	2.3	6.1	0.5	2.4	1.9	-2.0	0.2	0.9	1.0	1.3	0.7	-0.6	2.5	1.5	1.8
High blood pressure (mother)	0.4	0.5	2.0	-0.1	-0.7	0.0	-0.5	-0.3	-0.3	0.5	-1.4	-0.1	-1.3	-0.7	-0.5	-1.2
Body mass index (BMI)	1.0	4.1	11.1	2.5	1.0	1.2	1.7	-3.3	-2.8	1.4	-1.9	-1.2	2.4	1.8	2.6	0.0
Impedance of leg (left)	0.5	2.5	6.2	-1.3	1.2	1.4	-2.2	2.0	2.5	0.5	1.5	2.1	-1.4	0.3	-0.5	1.6
Leg predicted mass (left)	0.5	2.4	5.7	-0.0	-1.6	-1.9	2.0	-1.6	-2.4	-1.3	-2.4	-1.1	0.9	-1.3	-0.6	-1.1
Trunk fat mass	1.0	4.2	9.1	2.8	1.6	1.5	1.2	-3.0	-2.4	1.8	-1.7	-0.6	2.7	2.1	2.7	0.4
Waist circumference	0.8	3.1	9.3	1.4	-0.2	-0.0	2.0	-3.0	-2.9	0.4	-1.9	-1.6	2.4	0.5	1.9	-0.7
Number of incorrect matches in round	0.2	0.3	0.8	-0.2	0.7	0.6	0.8	-0.2	0.6	0.3	0.9	0.1	0.2	0.8	0.7	-0.2
Past tobacco smoking	1.1	1.9	4.1	1.9	1.8	2.0	-0.5	0.2	-0.9	1.9	-1.1	-0.1	0.7	1.9	1.6	1.1
Alcohol usually taken with meals	0.6	0.9	5.3	1.4	0.8	0.9	0.4	-0.2	0.5	0.8	0.3	0.8	2.3	0.6	0.5	0.7
Nervous feelings	1.9	3.6	9.9	-1.6	-2.4	-2.8	-0.2	-0.1	0.1	-2.8	-0.4	-1.9	-1.5	-1.7	-3.1	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.0	-0.5	-1.4	-0.4	1.3	0.2	0.1	-0.8	-0.5	-0.9	-0.7	-0.9	-1.4	-0.4
Hearing difficulty/problems with background noise	0.5	0.8	3.0	-0.1	-1.3	-0.7	1.3	-0.8	-0.2	0.3	-0.8	-0.9	-0.0	-1.2	-0.5	-1.7
Hair/balding pattern: Pattern 2	0.5	0.6	2.1	-0.0	-1.0	-1.5	-0.5	-0.7	-0.9	-1.3	-0.1	-0.5	0.8	-0.7	-0.4	-0.4
Had menopause	0.5	0.6	1.5	1.0	-1.0	-0.3	1.1	-0.1	0.4	0.8	0.9	-0.1	0.2	-1.2	-0.2	-1.2
Had other major operations	0.2	0.3	1.2	1.1	0.3	-0.3	-1.0	0.7	0.1	0.8	0.2	0.1	-0.2	0.2	0.2	0.1
Forced vital capacity (FVC)	1.4	5.6	19.7	-4.4	-2.0	-2.7	0.1	2.5	1.1	-3.4	-0.4	0.6	-2.1	-2.6	-3.2	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	6.0	0.9	1.5	0.9	-1.6	-2.4	-2.4	0.0	-1.5	-1.1	0.8	2.1	2.2	0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-0.5	-0.6	-0.3	0.1	0.9	0.3	-0.7	-0.9	0.9	-0.8	-0.8	-1.1	0.2
Qualifications: None of the above	0.2	0.5	1.8	-0.3	-1.0	-0.4	1.0	-0.3	0.2	0.1	-0.4	1.3	-0.1	-1.2	-0.5	0.4
Financial difficulties in last 2 years	0.4	0.6	1.8	-1.1	-1.0	-1.3	0.4	0.1	-0.4	-1.1	-0.4	-0.6	-0.3	-0.6	-1.1	-0.2
Mouth/teeth dental problems	0.3	0.4	1.6	-0.5	-0.1	-0.4	0.8	0.5	-0.1	-1.2	-0.5	0.2	0.5	-0.3	-0.8	1.0
Heart attack	0.8	1.0	3.4	-0.8	-1.0	-0.4	-0.3	1.6	0.8	-0.5	0.8	0.3	-1.9	-1.5	-1.2	-0.5
Allergy	0.4	0.9	2.8	-0.9	-0.9	-0.9	-0.5	-0.5	-0.9	-0.4	-1.4	-0.5	-1.7	-0.6	-0.9	-1.2
Pain all over the body in last month	0.6	0.7	2.6	0.6	1.2	0.5	-0.4	0.9	0.3	-0.0	-0.2	1.1	-0.6	1.1	0.5	1.6
Diabetes (self-reported)	0.4	0.6	3.7	-0.3	-0.3	0.5	1.9	-0.9	-0.0	1.0	0.2	-0.0	0.6	-0.5	1.1	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	3.7	0.2	0.7	0.6	0.6	0.4	1.0	0.2	0.5	1.1	-0.4	0.5	0.2	1.9
Medication: Ramipril	0.6	0.8	2.9	-0.3	1.0	1.7	0.3	1.5	1.2	0.8	1.1	0.7	-0.1	0.1	0.5	0.1
Medication: Simvastatin	0.1	0.1	0.5	0.0	0.2	0.3	0.3	-0.4	0.0	0.3	0.5	-0.4	0.3	0.5	0.7	-0.1
Fluid intelligence score	0.7	1.5	4.4	1.8	1.4	1.1	-1.1	-0.6	-0.5	1.2	1.3	-0.9	0.9	1.4	2.1	0.5
Illnesses of siblings	0.2	0.3	1.5	-0.2	0.3	-0.2	-1.0	0.5	0.5	-0.5	0.1	1.2	-0.5	-0.3	0.2	0.6
Neuroticism score	3.8	7.9	24.2	-2.9	-4.1	-3.8	0.6	1.0	0.1	-2.8	-0.8	-0.9	-3.2	-3.7	-4.9	-2.3
Weight	0.5	2.5	8.0	1.0	-0.8	-0.7	2.0	-2.8	-2.7	-0.2	-2.3	-1.2	1.7	-0.2	0.6	-0.9
Impedance of arm (right)	0.3	1.3	2.7	0.5	1.6	0.7	-1.0	0.9	1.5	0.9	1.4	1.1	0.1	1.4	0.5	1.7
Arm fat percentage (right)	1.7	6.7	14.7	3.8	2.2	2.2	1.3	-3.3	-2.5	2.7	-1.5	-0.9	3.2	2.9	3.8	0.8
Trunk fat-free mass	0.9	5.0	11.2	-2.0	-3.4	-3.0	1.5	-0.8	-1.7	-2.7	-2.3	-1.0	-0.5	-3.3	-2.5	-2.0
Hip circumference	0.7	2.9	8.8	1.0	-1.2	-0.8	2.5	-1.8	-3.0	-0.2	-1.8	-2.1	1.9	-0.8	0.9	-1.9
Time employed in main current job	0.8	0.9	3.0	1.7	-0.5	0.1	-0.6	-1.2	-0.5	0.5	0.0	-1.3	1.5	-0.4	0.1	-1.6
Alcohol intake versus 10 years previously	0.7	1.1	4.8	-0.2	0.7	0.1	1.0	0.1	1.9	-0.4	2.2	1.3	0.2	0.2	0.2	1.5
Father’s age at death	1.1	1.5	3.6	1.3	1.7	1.5	0.5	0.5	0.2	1.9	0.8	0.4	0.5	1.3	1.9	1.4
Worrier / anxious feelings	4.0	7.5	16.6	-2.7	-4.0	-3.7	0.6	-0.9	-0.8	-2.9	-0.1	-3.0	-1.7	-3.0	-4.1	-3.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.4	-0.1	0.1	0.3	0.7	0.7	1.5	-0.3	0.8	1.2	-0.3	-0.0	-1.0	1.0
Falls in the last year	0.6	0.8	1.7	0.7	-1.2	-0.6	1.0	-1.0	-0.6	-0.4	-1.1	-0.4	-1.1	-1.3	-0.5	-0.9
Hair/balding pattern: Pattern 3	0.3	0.5	3.1	-1.1	0.1	-0.4	-0.6	-0.1	-0.1	0.3	0.1	-0.5	-1.8	0.6	-0.9	-0.3
Number of live births	1.1	1.5	5.2	-0.1	-1.0	-0.5	0.9	2.3	1.7	-0.2	1.1	0.6	-1.6	-2.2	-0.7	-0.7
Forced expiratory volume in 1-second (FEV1)	1.8	5.9	25.0	-5.0	-1.9	-2.6	0.4	2.5	1.3	-3.6	0.2	0.1	-2.3	-2.4	-3.0	-0.2
Pulse rate	1.2	2.1	5.0	1.2	0.9	1.6	0.8	-2.1	-0.4	2.2	-0.8	0.3	2.2	1.7	1.8	0.8
Happiness	0.7	0.8	2.4	-1.3	-0.6	-1.0	0.7	1.1	1.0	-1.0	-0.3	0.7	-0.6	-0.7	-1.5	-0.3
Noisy workplace	0.6	0.7	2.4	-1.3	-1.0	-0.8	-0.4	-0.2	-0.2	-1.5	0.2	-0.4	-1.1	-0.8	-1.0	-0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.5	-0.7	0.0	-0.5	-0.1	0.1	0.2	0.2	1.2	-0.5	-0.5	0.0	0.1	-0.0
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	5.8	1.7	2.3	1.5	0.4	0.2	0.7	1.0	1.7	1.2	1.5	1.9	2.4	2.1
Mouth/teeth dental problems: Dentures	0.3	0.5	2.4	0.4	0.8	0.5	-1.6	0.2	0.1	0.5	0.4	0.5	-1.1	0.9	0.8	-0.0
Asthma	0.9	1.9	5.2	1.2	1.6	1.5	-0.0	0.5	1.5	0.8	2.1	0.9	1.2	1.0	2.3	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.7	-0.2	0.7	0.1	-0.4	0.2	0.1	-0.3	-0.4	0.3	0.7	0.8	-0.1	0.7
Medication: Cholesterol lowering	0.3	0.5	3.1	-0.8	-0.5	0.4	1.8	-0.3	-0.4	-0.5	0.2	-0.8	0.5	-0.4	0.1	-0.3
Depression (self-reported)	1.2	1.5	3.8	-0.6	-1.0	-1.5	0.9	0.5	2.0	-1.3	1.5	0.6	-1.1	-1.3	-1.9	-0.3
Medication: Lansoprazole	0.5	0.5	2.4	-0.2	0.9	1.6	0.3	-0.5	0.1	0.6	0.3	0.3	0.6	0.9	1.0	0.4
Prospective memory result	0.9	1.1	5.6	-2.2	-0.6	-0.9	0.3	-0.1	0.1	-2.4	0.3	-0.1	-0.9	-0.4	-1.1	0.1
Lung cancer (father)	0.4	0.5	1.5	-0.9	-0.5	-0.3	-0.7	-1.2	0.0	-0.8	0.6	-1.0	-0.4	0.2	-0.8	-0.9
Illnesses of mother	0.6	0.7	3.2	-1.8	-0.6	-0.7	-0.3	0.8	0.5	-1.3	0.1	0.4	-1.0	-0.7	-1.2	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	19.7	-4.4	-1.7	-2.5	0.1	1.6	0.6	-3.5	0.1	-0.7	-1.7	-1.9	-2.7	-0.5
Pulse wave Arterial Stiffness index	1.9	2.2	5.3	-0.2	-1.9	-1.3	1.1	-1.9	-2.1	-0.8	-1.2	-2.3	0.2	-1.3	-0.5	-2.0
Impedance of arm (left)	0.4	1.9	4.3	0.6	2.0	1.2	-0.7	1.3	1.8	1.1	1.6	1.3	0.4	1.6	0.8	2.1
Arm fat mass (right)	0.9	3.5	8.1	2.6	1.0	1.0	1.7	-2.9	-2.5	1.4	-1.8	-1.0	2.3	1.5	2.5	0.1
Trunk predicted mass	0.9	5.3	11.6	-2.2	-3.4	-3.1	1.4	-0.8	-1.8	-2.8	-2.4	-1.1	-0.7	-3.3	-2.6	-2.1
Standing height	0.8	8.0	18.8	-3.2	-3.9	-4.2	0.6	0.9	-0.1	-3.8	-1.4	-0.2	-1.5	-4.3	-4.3	-2.1
Length of working week for main job	0.9	1.0	3.0	0.8	1.6	1.7	-1.2	-0.4	0.3	0.5	0.8	0.3	0.2	1.4	1.1	1.1
Exposure to tobacco smoke at home	0.8	0.9	2.0	-1.1	-1.1	-0.9	0.4	-0.8	-0.6	-1.2	-0.8	-1.1	-1.4	-0.9	-0.4	-1.1
Breastfed as a baby	0.4	0.5	1.6	0.4	-1.0	-1.3	0.3	-1.3	-0.5	0.2	-0.6	-0.3	0.6	-0.4	-0.5	-0.8
Tense / ‘highly strung’	1.5	2.4	6.9	-1.9	-2.1	-1.8	0.4	-0.4	-0.5	-1.7	-1.6	-0.6	-1.7	-1.5	-2.6	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	4.0	0.6	0.9	1.1	-0.2	2.0	1.1	0.7	1.0	0.8	-1.6	0.4	0.6	0.9
Hair/balding pattern: Pattern 4	0.8	1.9	6.7	-0.7	-1.5	-0.1	2.6	-0.7	-0.8	-0.7	-0.5	-1.8	1.0	-1.6	0.5	-2.3
Birth weight of first child	0.4	0.6	1.5	-0.6	0.9	0.9	1.0	0.8	-0.1	-0.3	-0.7	1.2	0.5	0.3	1.0	1.2
Peak expiratory flow (PEF)	1.7	4.0	11.8	-2.7	-0.2	-1.0	0.3	3.3	3.4	-2.4	2.8	1.1	-0.8	-1.5	-1.4	0.5
Pulse wave reflection index	0.6	0.7	3.1	-0.5	-0.4	-0.7	0.5	-0.7	-0.9	-1.8	0.8	-1.5	0.4	-0.2	-0.3	-0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.7	-1.1	-0.9	-1.2	0.1	-0.6	0.9	-1.7	0.9	-0.3	-0.0	-0.8	-1.0	-1.0
Loud music exposure frequency	0.6	0.7	2.6	-0.5	1.3	1.2	-1.3	0.3	0.6	0.1	-0.1	-0.4	-0.6	1.6	0.2	0.7
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	8.0	0.6	2.0	1.3	-0.7	2.0	1.8	1.5	2.8	1.1	0.5	1.6	1.1	2.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.6	0.6	-0.1	-0.1	0.1	-1.0	-0.9	0.7	-1.3	-1.3	0.3	0.1	0.6	-1.0
Blood clot in the leg (DVT)	0.9	1.2	3.6	0.4	-1.6	-0.6	1.0	-1.9	-1.1	-0.7	-0.8	-1.2	1.0	-1.0	-0.6	-1.2
Medication: Paracetamol	0.3	0.5	3.7	-0.9	-0.2	-0.7	0.0	0.3	-0.2	-1.9	-0.7	0.0	-0.2	-0.4	-0.3	-0.0
Headache pain in last month	0.6	1.0	3.0	-0.3	-1.7	-1.2	1.7	-0.9	0.5	-1.1	-0.2	-0.0	0.5	-1.6	-0.8	-0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.8	0.5	-0.5	-1.2	-1.4	0.2	0.3	-0.0	-0.2	0.2	-1.0	-0.5	-0.8	-0.0
Glaucoma (self-reported)	1.1	1.3	3.9	2.0	0.4	1.1	1.7	1.7	0.6	1.2	0.4	0.4	1.9	-0.3	0.7	0.0
Gout (self-reported)	0.4	0.5	1.8	-1.3	-0.3	-0.1	-0.2	-0.5	-1.0	-0.4	-1.3	-0.7	-1.2	0.2	-0.2	-0.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	6.2	0.7	1.3	2.0	-0.2	1.6	1.0	1.2	1.1	2.5	0.6	0.2	1.3	1.3
Medication: Amlodipine	0.2	0.3	2.8	-0.2	0.1	0.1	1.7	0.5	0.4	-0.2	0.1	0.2	-0.8	-0.2	0.4	0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	3.2	-0.1	-0.2	-0.1	1.0	-0.3	0.1	-0.8	1.8	-0.1	0.9	-0.5	0.9	0.1
Birth weight	0.4	0.9	2.8	-1.6	-1.2	-0.6	0.1	0.2	0.1	-0.6	0.1	-1.1	-0.8	-1.2	-1.1	-1.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.8	1.7	0.2	0.5	0.5	0.2	-0.1	0.5	-1.6	1.3	0.2	0.0	0.1	1.1
High blood pressure (siblings)	0.4	0.5	2.6	-0.7	-0.5	-0.3	-0.4	-0.3	-1.1	-0.4	-0.2	-1.6	0.6	0.3	-0.7	-1.0
Forced vital capacity (FVC), Best measure	0.9	3.4	13.5	-3.7	-1.2	-1.9	-0.4	2.1	1.0	-3.0	0.2	0.4	-1.6	-1.7	-2.4	0.0
Body fat percentage	1.6	6.5	14.4	3.8	2.4	2.5	0.8	-3.2	-2.2	2.9	-1.2	-0.5	3.0	3.0	3.6	0.9
Leg fat percentage (right)	1.1	3.9	7.8	2.6	1.6	2.2	0.8	-2.7	-1.7	2.4	-0.6	-0.4	2.5	2.1	2.8	0.7
Arm fat-free mass (right)	0.5	2.5	4.9	-1.3	-2.1	-1.8	1.4	-0.9	-1.8	-2.0	-2.2	-0.7	-0.2	-2.0	-1.6	-1.3
Exposure to tobacco smoke outside home	0.4	0.6	4.1	0.4	-0.0	-0.4	2.0	-0.5	-0.1	0.4	-0.4	0.5	1.3	-0.1	0.4	0.6
Comparative body size at age 10	0.7	1.8	5.2	-2.2	-0.9	-1.5	-0.1	-1.9	-1.1	-2.3	-0.7	-1.4	-1.5	-0.1	-0.9	-0.6
Number of full brothers	0.1	0.1	0.4	0.2	0.4	-0.3	-0.6	-0.3	0.2	-0.3	0.2	0.4	-0.2	0.6	0.1	0.1
Worry too long after embarrassment	1.6	2.7	7.3	-0.8	-2.7	-2.6	-0.2	-0.6	-0.6	-0.7	-0.9	-0.7	-1.6	-2.2	-2.7	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.9	0.2	-0.3	-0.6	0.2	0.6	1.4	-0.8	0.9	1.3	-0.7	-0.7	-0.6	0.5
Wheeze or whistling in the chest in last year	0.3	0.6	1.6	0.3	0.6	0.9	-0.4	-0.3	-1.3	-0.2	-1.1	0.1	1.0	0.9	1.0	0.8
Number of children fathered	0.2	0.2	0.7	0.2	-0.0	-0.4	-0.2	0.0	0.4	-0.8	-0.4	0.1	-0.0	-0.1	-0.9	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	6.2	-2.5	-0.3	0.1	0.1	-0.0	-0.1	-0.0	-0.3	-0.8	-2.4	-0.3	0.0	-0.2
Age at first live birth	0.6	1.0	2.9	-0.3	-0.0	-0.4	-1.1	-1.6	-1.7	-0.6	-1.4	-1.1	0.7	0.8	-0.6	-1.2
Pulse wave peak to peak time	1.9	2.3	6.5	-0.0	1.7	1.2	-0.9	2.2	2.3	0.8	1.2	2.5	-0.4	1.0	0.3	2.1
Health satisfaction	1.6	2.0	6.1	0.4	2.1	2.5	-0.4	0.0	0.2	1.3	-0.2	1.3	0.5	2.2	1.3	2.2
Shortness of breath walking on level ground	0.4	0.4	2.1	-0.2	-0.7	-0.4	0.2	-0.7	0.4	-0.6	0.2	-0.6	-1.4	-0.4	-1.0	-0.5
Qualifications: College or University degree	0.3	0.9	4.1	-0.3	-0.1	0.0	1.0	-1.0	-1.2	-0.2	-0.3	-2.0	1.6	0.4	0.5	-0.7
Eye problems/disorders: None of the above	0.5	0.5	2.5	-0.7	-0.1	-0.6	-1.6	-0.2	-0.1	0.1	-1.2	0.0	-1.3	-0.0	-0.5	0.0
Mouth/teeth dental problems: Loose teeth	2.0	2.3	5.8	-1.4	-1.7	-2.2	-0.7	-0.6	-0.1	-2.4	0.4	-2.0	-0.7	-1.2	-2.0	-1.9
Emphysema/chronic bronchitis	1.9	2.1	10.7	2.1	0.6	1.3	1.4	-1.2	-0.7	1.1	-0.5	0.4	3.3	0.6	2.0	-0.0
Medication for pain relief, constipation, heartburn	0.3	0.4	3.1	0.7	-0.0	0.3	-0.1	-0.3	-0.0	1.8	1.0	-0.4	-0.2	0.1	0.8	-0.4
Neck or shoulder pain in last month	1.2	1.8	4.3	-2.1	-2.0	-1.3	0.1	-0.1	-0.5	-1.4	-0.9	-0.1	-1.7	-1.6	-1.9	-0.7
Medication: Blood pressure	0.2	0.4	1.5	-0.7	0.9	1.2	0.3	0.3	0.0	0.5	0.1	0.5	0.1	0.8	0.7	0.4
Angina (self-reported)	0.4	0.5	2.7	-0.6	-0.5	0.2	0.8	0.6	0.3	-0.5	0.4	-0.7	-1.6	-0.6	-0.1	-0.8
Migraine (self-reported)	2.9	3.7	6.3	-1.1	-2.5	-2.1	-0.7	-1.5	-2.3	-2.5	-2.0	-1.9	-0.7	-1.7	-2.1	-2.3
Medication: Ibuprofen	0.4	0.4	1.5	-0.1	0.8	-0.0	-0.8	-0.3	-0.5	-0.9	-0.7	-0.1	0.9	1.2	-0.2	0.8
Medication: Allopurinol	1.2	1.7	4.5	0.2	1.7	1.8	-1.6	-0.5	-1.0	1.0	-1.3	0.5	-0.5	2.1	1.3	1.5
Medication: Omeprazole	0.6	0.7	2.1	0.2	-0.7	-1.5	-1.3	0.3	0.4	-1.2	0.2	0.1	-0.9	-0.5	-1.4	-0.7
Medication: Seretide 50 evohaler	0.6	0.7	3.1	-0.8	-0.7	-0.3	0.2	-1.7	-1.4	-0.4	-0.9	-0.7	0.3	-0.3	0.0	-0.8
Mean time to correctly identify matches	0.6	1.2	4.2	2.0	-0.3	-0.0	1.1	0.1	1.2	1.2	2.0	1.2	1.0	-0.7	0.6	0.3
Heart disease (mother)	1.2	1.4	5.1	-1.5	-1.1	-2.0	0.1	-0.2	0.2	-1.5	0.4	-0.9	-2.3	-0.8	-1.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	4.2	0.0	1.2	0.4	-0.6	2.1	0.3	-0.1	-0.2	0.7	-0.5	0.9	-0.0	1.4
Whole body fat mass	0.9	3.6	9.8	2.4	1.0	1.1	1.5	-3.1	-2.5	1.5	-1.8	-1.0	2.5	1.6	2.2	-0.0
Leg fat mass (right)	0.6	2.5	6.5	1.9	0.8	1.2	1.2	-2.6	-2.1	1.4	-1.5	-0.6	2.1	1.3	2.0	0.3
Arm predicted mass (right)	0.5	2.6	5.8	-1.3	-2.0	-1.9	1.3	-0.8	-1.9	-1.9	-2.4	-0.6	-0.2	-1.9	-1.5	-1.3
Pulse rate, automated reading	1.1	3.7	7.1	2.2	2.3	2.4	-0.7	-0.5	0.2	2.5	0.8	1.3	1.9	2.7	2.3	2.5
Alcohol intake frequency.	0.5	1.2	4.9	2.2	0.9	0.9	0.4	-0.8	0.6	1.3	0.1	1.5	1.3	0.8	0.8	1.0
Comparative height size at age 10	0.4	1.9	5.0	-1.8	-2.0	-2.2	-0.1	-0.5	-0.5	-1.1	-0.9	-0.1	-0.8	-1.9	-1.8	-1.7
Number of full sisters	1.2	1.5	4.2	-1.0	-1.6	-1.4	1.0	1.2	1.3	-0.6	0.7	0.7	-1.0	-2.1	-1.8	-0.2
Suffer from ‘nerves’	2.3	3.6	8.5	-2.6	-2.2	-2.2	1.1	-0.7	-1.5	-2.8	-1.4	-1.5	-1.6	-1.2	-2.9	-1.0
Overall health rating	0.7	1.5	4.1	1.3	1.1	1.3	1.1	0.1	0.9	0.8	0.7	1.9	1.4	1.0	1.1	2.0
Chest pain or discomfort	0.4	0.5	2.3	1.3	-0.0	0.2	1.5	-0.6	-0.5	0.4	-0.4	-0.6	0.5	0.0	1.0	0.3
Had major operations	0.9	1.0	3.1	1.3	1.3	0.9	-0.4	-1.1	-0.6	0.7	0.0	-0.7	1.2	1.8	1.3	0.1
Age at last live birth	0.1	0.1	0.6	-0.7	0.4	0.3	0.4	0.1	-0.2	-0.3	0.3	-0.4	-0.1	0.4	-0.1	0.1
Family relationship satisfaction	1.1	1.3	4.4	-1.8	-1.2	-1.1	0.0	0.4	-0.5	-2.1	-0.3	-0.9	-1.2	-0.7	-1.9	-0.5
Leg pain on walking	0.3	0.3	1.2	0.8	0.6	0.8	-0.1	-1.1	-0.2	-0.1	-0.9	0.1	-0.2	0.8	0.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.5	0.3	1.4	0.8	-1.9	-0.5	-0.5	0.5	0.9	-0.4	-0.6	1.7	0.8	0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.5	1.2	0.2	0.9	-1.0	0.4	-0.1	0.9	0.2	0.5	0.5	-0.1	0.3	0.0
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	3.7	-1.7	-1.7	-1.2	-1.2	0.7	0.3	-1.0	-0.3	-0.4	-1.9	-1.7	-1.9	-1.8
Medication: Aspirin	0.3	0.4	2.1	0.2	-0.0	0.3	1.5	0.9	0.5	0.1	0.4	0.8	0.3	-0.7	-0.3	0.9
Supplements: Vitamin C	0.9	1.1	3.1	-1.8	0.1	-1.2	-1.3	0.4	0.4	-1.2	1.6	-0.4	-1.7	0.1	-0.5	-0.2
Knee pain experienced in last month	0.7	1.1	2.7	0.6	1.3	1.7	-0.9	0.5	0.0	1.3	1.1	0.4	-0.1	1.3	1.5	1.0
Hypertension (Self-reported)	0.6	1.8	5.8	0.2	1.9	1.5	-0.6	-1.4	-1.6	0.3	-1.4	-0.4	-0.4	2.4	1.9	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	5.0	-0.1	0.3	0.5	-1.1	2.2	1.4	0.3	1.3	1.4	-0.1	-0.3	0.2	0.7
Illnesses of father: Heart disease	0.4	0.5	2.6	-0.9	-0.8	0.0	0.7	-0.9	0.2	-0.6	-0.5	-0.2	-0.1	-1.0	-0.0	-1.6
Illnesses of siblings: Diabetes	0.9	1.0	4.2	-1.0	-0.5	-0.9	-2.1	-1.0	-0.5	-0.5	-0.3	-0.7	-1.8	0.2	-0.8	-1.1
Smoking status: Previous	1.3	2.0	4.8	-2.1	-2.0	-2.2	0.3	-1.2	-0.1	-1.9	0.0	-0.6	-0.4	-1.6	-1.1	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	5.6	-2.0	-0.8	-1.6	0.5	0.0	0.5	-2.4	-0.4	-0.0	-1.1	-0.7	-2.1	0.4
Whole body fat-free mass	0.6	3.7	7.3	-1.3	-2.7	-2.6	1.8	-1.1	-2.0	-2.1	-2.4	-1.0	0.1	-2.6	-1.8	-1.7
Leg fat-free mass (right)	0.5	2.6	6.2	0.1	-1.7	-1.9	2.1	-1.6	-2.4	-1.4	-2.5	-1.1	1.1	-1.4	-0.5	-1.3
Arm fat percentage (left)	1.7	6.6	14.1	3.7	2.4	2.4	1.6	-3.0	-2.2	2.6	-1.1	-0.6	3.4	3.0	3.8	1.1
Average weekly red wine intake	0.6	0.9	2.5	0.4	1.0	0.7	-0.9	-0.2	1.3	1.0	1.6	0.7	-0.6	0.9	0.7	1.3
Handedness (chirality/laterality): Left-handed	0.6	0.8	4.1	0.0	0.2	0.8	0.6	-1.1	-0.9	0.3	-0.4	0.8	1.1	-0.1	2.0	0.7
Mood swings	2.2	4.0	11.9	-2.1	-2.1	-2.0	0.9	2.3	2.1	-2.2	1.3	0.8	-1.6	-2.7	-3.4	-0.3
Loneliness, isolation	0.7	1.0	3.2	0.3	-1.5	-0.6	1.8	0.6	0.1	-0.4	-0.8	0.0	0.1	-1.6	-1.6	-0.9
Long-standing illness, disability or infirmity	1.3	2.0	5.1	1.3	2.1	1.9	-1.2	0.3	0.2	0.3	0.9	1.0	0.9	2.0	1.4	2.3
Ever had bowel cancer screening	0.8	0.9	3.5	0.8	-0.9	0.4	1.1	1.3	0.6	0.5	1.1	0.9	-0.0	-1.9	-0.2	-1.1
Diabetes diagnosed by doctor	0.3	0.5	2.6	-1.1	-0.0	0.7	1.6	-0.4	0.1	0.5	0.3	0.0	-0.2	-0.3	0.9	0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	4.2	-1.5	-1.5	-1.3	1.0	-2.0	-1.6	-1.9	-2.0	-1.8	-1.1	-0.8	-1.2	-1.3
Friendships satisfaction	0.4	0.5	1.2	-0.3	0.9	0.7	-1.1	1.0	0.4	-0.4	0.2	0.4	-0.3	1.0	-0.8	1.0
Qualifications: nursing, teaching	0.5	0.8	3.0	1.0	-0.1	0.3	-0.9	-1.0	-1.7	0.2	-0.8	-1.7	0.3	0.5	0.3	-0.9
Commuting to job workplace: Walk	0.5	0.5	2.1	-0.1	-0.5	-0.3	1.0	-1.4	-0.9	-0.4	0.1	-1.0	0.8	-0.1	0.7	-0.6
Eye problems/disorders: Cataract	0.3	0.3	1.3	-0.2	-0.4	0.0	0.5	-1.1	0.1	-0.6	1.1	-0.6	0.4	-0.1	0.2	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.1	0.9	-0.3	1.0	0.6	0.0	0.5	1.4	0.9	0.2	0.5	-0.4	0.5	-0.6
Medication for cholesterol	1.0	1.5	3.7	-1.9	-1.8	-1.9	0.6	0.1	-0.2	-1.2	-0.4	-0.7	-1.2	-1.8	-1.4	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.2	-0.2	0.1	0.2	-0.6	1.1	1.1	0.1	0.2	0.4	-0.3	-0.0	-0.4	0.2
Back pain experienced in last month	1.1	1.6	5.1	-1.4	0.6	0.2	-0.4	2.3	1.7	-0.2	1.5	1.9	-0.8	0.0	-0.6	1.8
Mineral and other dietary supplements	1.7	2.3	10.1	-0.5	-1.7	-1.4	0.8	-1.3	-2.6	-0.7	-3.2	-0.8	-0.1	-1.3	-0.9	-1.2
Breast cancer (self-reported)	1.7	2.0	4.4	2.0	1.9	2.1	-0.3	0.3	0.2	2.1	-0.2	1.4	1.1	1.7	1.3	1.4
Asthma (self-reported)	0.8	1.5	4.7	1.0	1.6	1.2	0.0	0.3	1.3	0.5	1.9	0.8	1.2	1.1	2.2	1.2
Osteoporosis (self-reported)	0.8	0.9	2.4	1.6	1.2	1.4	-0.6	1.0	-0.3	0.7	0.2	0.9	1.0	0.9	1.2	0.9
Osteoarthritis (self-reported)	3.2	4.1	8.0	2.8	2.5	2.8	-0.2	-0.4	-0.0	2.7	1.4	1.0	1.7	2.5	2.5	2.3
Medication: Aspirin	0.3	0.4	1.1	0.7	-0.0	0.2	1.1	0.7	0.4	0.3	0.6	0.7	0.9	-0.7	-0.1	0.8
Medication: Gliclazide	0.8	0.9	2.8	-1.2	-0.6	-1.3	-1.0	-1.0	-1.3	-1.7	-0.7	-0.8	-0.2	-0.1	-0.8	-0.5
Illnesses of father: None of the above (group 1)	0.8	1.0	3.4	-0.2	-1.1	-0.6	1.8	0.4	0.6	-0.8	0.7	0.3	1.8	-1.6	-0.7	-0.4
Smoking status: Current	0.9	1.4	5.6	0.9	0.1	0.5	0.6	2.4	1.8	-0.2	1.5	1.3	-1.2	-0.7	-1.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	10.2	-3.2	-0.1	0.2	-0.1	1.4	-0.1	-0.6	-0.4	0.4	-0.4	-0.1	-1.3	0.7
Whole body water mass	0.7	3.8	7.3	-1.2	-2.7	-2.7	1.7	-1.1	-2.1	-2.2	-2.4	-1.1	0.1	-2.5	-1.8	-1.8
Leg predicted mass (right)	0.5	2.5	6.0	0.1	-1.7	-1.9	2.2	-1.5	-2.3	-1.3	-2.5	-1.0	1.1	-1.5	-0.5	-1.2
Arm fat mass (left)	0.8	3.3	8.8	2.2	0.8	0.8	1.8	-3.0	-2.6	1.0	-2.0	-1.1	2.2	1.4	2.2	0.1
Number of self-reported non-cancer illnesses	1.4	2.5	7.2	1.7	2.4	2.1	-0.6	-0.5	-0.5	1.4	0.2	0.6	0.9	2.7	2.2	1.6
Average weekly champagne plus white wine intake	0.4	0.5	1.6	-0.7	0.8	0.1	-0.6	-0.1	-0.2	-0.0	-1.3	1.1	-0.5	0.7	0.2	1.2
Miserableness	1.8	3.2	12.6	-0.6	-1.6	-0.7	2.0	3.5	2.1	-0.5	1.4	1.7	-0.5	-2.9	-1.7	0.5
Guilty feelings	1.1	1.7	4.8	-0.8	-1.8	-1.4	0.8	1.1	1.3	-0.7	0.8	0.0	-1.3	-2.2	-1.6	-1.3
Wears glasses or contact lenses	1.6	1.8	5.0	1.4	0.5	1.2	2.0	-0.7	-0.3	1.5	1.3	-1.2	2.2	0.8	2.0	-0.5
Ever taken oral contraceptive pill	0.7	0.8	2.2	-0.7	-1.5	-1.2	0.3	-0.8	-0.7	-0.7	-0.8	-1.1	0.0	-1.0	-0.8	-0.9
Hearing aid user	0.3	0.4	1.8	-1.3	0.3	0.4	-1.0	0.2	0.8	0.0	0.7	0.6	0.1	0.3	0.2	0.2
Mother’s age at death	1.1	1.4	4.5	0.6	-1.2	-0.6	1.7	-0.6	-0.6	-0.7	1.1	-1.6	1.3	-1.2	-0.0	-2.1
Financial situation satisfaction	0.5	0.6	2.9	-0.6	0.6	-0.3	-1.7	-0.1	0.1	-0.7	0.5	-0.4	-0.6	1.3	-0.7	0.9
Tinnitus: Yes, now most or all of the time	0.7	0.9	4.7	-0.4	-1.5	-0.8	1.0	-0.1	0.1	-0.4	-0.8	0.8	0.2	-2.2	-0.5	-0.8
Commuting to job workplace: Public transport	1.1	1.3	6.0	0.5	1.4	1.0	0.9	0.8	-0.7	0.9	-0.8	1.0	0.6	1.2	1.3	2.4
Eye problems/disorders: Glaucoma	0.8	1.0	4.1	1.3	0.5	0.9	1.0	2.0	0.9	1.1	0.8	1.0	0.9	-0.3	0.7	0.4
Medication: Blood pressure	0.5	1.0	2.7	0.7	1.1	0.5	-1.6	-1.1	-1.3	-0.4	-1.1	-0.2	-0.6	1.6	0.7	0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.7	0.5	-0.9	-0.3	-0.2	-0.5	-0.7	-0.1	-1.3	0.3	-0.5	-0.9	-0.5	-0.7
Supplements: Fish oil (including cod liver oil)	2.1	2.8	9.6	0.3	1.9	1.5	-0.5	1.8	2.9	0.8	3.1	1.6	0.2	1.3	0.7	1.8
High cholesterol (Self-reported)	0.2	0.3	1.1	-0.8	-0.3	0.1	0.6	-0.8	-0.4	-0.3	-0.3	-0.2	1.0	-0.0	0.6	-0.7
Medication: Bendroflumethiazide	0.8	1.2	4.1	0.4	1.7	1.5	-1.9	0.1	0.1	0.2	-0.4	0.4	-0.1	2.0	0.3	1.3
Medication: Paracetamol	0.3	0.5	4.7	-0.8	0.1	-0.6	0.2	-0.0	-0.4	-2.2	-0.7	-0.5	-0.2	0.1	-0.1	-0.1
Medication: Lisinopril	0.3	0.4	1.8	-1.4	-0.1	-0.7	-0.9	-0.5	0.0	-0.3	0.1	0.5	-1.3	0.2	-0.0	-0.0
Medication: Atorvastatin	0.3	0.4	1.9	-1.4	-0.1	0.8	0.5	0.5	0.0	-0.7	-0.1	0.8	-0.7	-0.4	-0.0	-0.1
Illnesses of father: High blood pressure	0.5	0.6	2.6	-0.4	0.2	0.1	-1.1	1.0	-0.6	0.3	-1.4	0.0	-1.6	0.3	-0.6	-0.0
Alcohol drinker status: Never	1.6	1.9	4.9	0.6	2.2	1.5	-0.3	0.7	1.1	1.0	0.5	1.7	0.6	2.0	1.5	2.1
Ever smoked	1.1	1.9	4.1	-0.6	-2.0	-2.0	1.6	-0.3	1.0	-1.3	1.2	-0.2	-0.6	-2.0	-1.9	-1.1
Basal metabolic rate	0.5	2.8	5.9	-0.8	-2.2	-2.1	1.8	-1.4	-2.2	-1.7	-2.4	-1.0	0.4	-2.0	-1.2	-1.4
Leg fat percentage (left)	1.3	4.8	9.5	2.9	1.9	2.5	0.7	-2.9	-1.8	2.7	-0.9	-0.3	2.8	2.4	3.1	0.8
Arm fat-free mass (left)	0.6	3.0	5.9	-1.2	-2.4	-2.1	1.4	-1.1	-1.9	-1.9	-2.4	-0.7	-0.5	-2.4	-1.5	-1.7
Number of operations (self-reported)	0.5	0.7	1.8	1.3	0.8	0.4	0.6	-0.2	-0.7	0.8	0.6	-0.6	1.3	1.1	1.2	-0.2
Average weekly beer plus cider intake	0.5	0.7	3.1	-0.8	0.1	0.3	1.0	-0.1	1.8	0.5	1.7	0.9	0.3	-0.5	0.6	0.1
Irritability	0.7	1.3	3.7	-1.7	-1.2	-1.4	0.6	-0.7	-0.1	-1.9	-0.8	-0.3	-1.1	-0.8	-1.7	-0.6
Risk taking	0.5	0.7	2.9	-0.8	-1.0	0.3	1.7	-0.9	-1.1	-0.2	-0.9	-1.2	-0.0	-0.6	-0.5	-0.3
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.1	1.7	1.0	1.3	0.4	1.2	1.1	1.4	1.4	1.8	1.4	0.2	1.4	1.2
Fractured/broken bones in last 5 years	0.8	1.1	3.7	-0.7	-1.3	-1.9	0.3	1.3	0.2	-0.8	0.7	0.4	-0.6	-1.9	-0.9	-0.6
Age started oral contraceptive pill	0.7	0.8	2.9	0.3	-0.6	0.2	1.1	-1.4	-0.8	0.6	-0.3	-1.5	1.0	0.0	-0.0	-1.7
Diastolic blood pressure, automated reading	2.0	6.3	15.6	1.9	3.2	3.2	-0.9	-2.0	-1.8	3.0	-1.5	0.3	1.2	4.0	3.9	2.3
Ever depressed for a whole week	0.5	0.7	2.2	0.4	-0.8	-0.9	0.8	-0.5	-0.7	-0.6	-1.5	-0.6	0.1	-0.8	-0.7	-1.3
Unable to work because of sickness or disability	0.2	0.3	1.1	0.8	-0.7	-0.0	1.0	-0.1	0.4	-0.2	0.3	-0.0	0.2	-0.6	-0.7	0.0
Commuting to job workplace: Cycle	0.4	0.5	1.4	0.5	-0.3	-0.9	0.5	0.9	1.2	-0.3	0.8	0.2	1.0	-0.9	0.3	-0.8
Myopia	0.6	0.9	3.8	-0.3	0.4	-0.0	0.5	1.5	1.5	0.8	1.9	1.4	0.2	-0.1	0.4	0.7
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.4	0.1	-1.5	-0.9	0.9	0.8	1.2	0.2	1.1	0.2	1.0	-1.9	-1.1	-0.6
Cholesterol lowering medication	0.4	0.5	1.2	0.4	0.6	0.7	-0.3	0.2	0.5	1.1	1.0	0.8	0.9	0.6	1.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.2	1.1	-0.1	-0.3	-1.1	0.1	0.7	-0.6	0.5	0.3	0.2	-0.1	-0.7	-0.1
Pain experienced in last month	0.3	0.4	1.8	1.4	0.1	-0.0	-0.1	-0.1	-0.4	0.9	-0.9	-1.0	0.4	-0.1	0.3	-0.9
Supplements: Calcium	0.3	0.3	1.1	1.0	0.3	0.4	-0.6	-0.4	-0.2	0.5	-0.1	-1.0	0.0	0.8	0.3	-0.7
Basal cell carcinoma (self-reported)	0.7	0.8	3.0	0.2	-1.4	-1.1	1.7	-1.1	-0.5	-0.3	-0.5	-0.1	0.6	-1.5	-0.2	-0.3
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.4	-0.8	-1.1	-0.4	-0.2	1.5	0.6	-0.4	0.8	0.2	-1.8	-1.5	-1.2	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	3.7	0.1	-1.9	-0.9	1.3	-1.8	-0.9	-1.1	-0.4	-1.5	1.2	-1.4	-0.8	-1.5
Heart disease (siblings)	2.6	3.2	10.0	2.5	1.0	1.5	3.2	-0.3	0.8	2.5	0.7	1.2	2.5	0.5	2.2	1.4
Alcohol drinker status: Previous	0.4	0.4	1.4	0.9	-0.9	-1.1	0.7	0.7	0.0	0.1	-0.3	0.4	-0.4	-1.2	-0.4	-0.3
Pack years of smoking	0.2	0.3	1.5	1.2	0.1	0.1	-0.2	-1.0	0.3	0.1	0.5	-0.5	0.3	0.6	-0.6	-0.3
Impedance of whole body	0.3	1.7	3.7	-0.3	1.5	1.0	-1.8	1.4	1.9	0.7	1.4	1.4	-0.8	1.1	-0.1	1.7
Leg fat mass (left)	0.7	2.8	7.3	2.1	0.9	1.2	1.3	-2.7	-2.2	1.4	-1.7	-0.6	2.3	1.3	2.1	0.2
Arm predicted mass (left)	0.7	3.7	7.7	-1.3	-2.6	-2.4	1.1	-1.3	-2.3	-1.9	-2.8	-1.1	-0.5	-2.4	-1.7	-2.0