Hub : Genes

NOS1AP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Left Ventricle 0.163 0.0560 0.00086 0.045 NA 0.014 NA 0.039 2.0e-03 NA 5.4e-02 NA 3.8e-03
2 GTEx Testis 0.227 0.0910 0.00700 0.179 NA 0.130 NA 0.021 2.2e-08 NA 2.3e-06 NA 4.0e-02
3 METSIM Adipose 0.052 0.0196 0.00031 0.048 0.020 0.031 0.026 0.033 9.7e-08 0.00047 1.9e-05 6.7e-05 8.4e-06
4 TCGA Colon Adenocarcinoma 0.073 0.0360 0.00750 -0.002 0.001 -0.004 NA -0.005 4.5e-01 0.27000 7.1e-01 NA 8.9e-01
5 TCGA Thyroid Carcinoma 0.126 0.0540 0.00230 0.034 0.022 0.052 NA 0.060 2.6e-04 0.00270 7.4e-06 NA 1.6e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.8 1.2 5.5 2.3 -0.5 0.4 0.3 -0.5
Bipolar Disorder or Schizophrenia 0.4 1.1 2.3 1.4 0.3 -1.0 -0.1 -1.5
Depressed Affect (Nagel 2018) 0.4 0.9 1.6 1.1 1.2 1.2 0.3 -0.2
Depression (Nagel 2018) 0.3 0.4 1.1 1.1 0.3 0.4 0.7 -0.3
Intelligence (Savage-Jansen 2018) 0.5 1.6 2.9 -0.4 1.5 -1.3 -1.7 -1.0
Neuroticism (Nagel 2018) 0.4 1.0 3.3 0.8 1.8 0.5 -0.3 0.8
Schizophrenia (2018) 0.5 1.1 2.4 -0.1 0.7 -1.5 -0.4 -1.6
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 -0.2 0.4 0.0 0.2 0.4
Worry (Nagel 2018) 0.4 0.8 1.9 0.6 1.4 -0.7 -0.8 0.7
Alzheimer’s Disease (in mother) 0.5 0.6 1.4 -0.2 0.1 0.7 -1.0 -1.2
Alzheimer’s Disease (in father) 1.4 1.5 3.4 1.8 -1.1 0.8 1.5 0.3
Alzheimer’s Disease (including proxy) 0.4 0.6 1.5 0.2 0.1 1.0 -0.7 -1.2
Crohns Disease (2017) 1.0 2.2 3.9 -1.2 1.4 -1.4 -2.0 -1.4
Irritable Bowel Disease (IBD) 0.6 1.4 3.6 -0.4 1.1 -1.1 -0.9 -1.9
Ulcerative Colitis (UC) 0.4 0.8 2.9 0.5 0.1 -0.6 0.6 -1.7
Major Depression (MDD) 1.5 1.8 3.6 -1.5 0.5 -1.9 -1.3 1.2
Reaction Time 1.4 2.7 4.5 1.5 -1.2 2.1 1.9 -1.3
Verbal and Numeric Reasoning (VNR) 0.9 2.1 4.6 -0.9 1.5 -1.5 -2.1 -0.9
Breast Cancer 0.9 2.2 6.4 -1.0 1.7 -2.5 -0.6 0.3
Ovarian Cancer 1.0 1.3 3.4 -1.9 -0.9 -0.6 -1.3 -0.0
Prostate Cancer 1.2 1.6 2.5 -1.6 -0.3 -1.4 -1.1 1.5
Age at First Birth 0.9 1.3 2.1 1.4 -1.1 1.0 1.4 0.5
Bipolar Disorder (2011) 0.8 0.8 2.5 1.6 0.7 0.0 1.0 0.2
Body Mass Index (BMI) (2010) 4.4 6.0 9.4 2.7 -2.4 3.1 2.7 0.0
Coronary Artery Disease (CAD) 0.3 0.4 1.0 -0.6 -1.0 0.7 -0.1 0.1
Crohns Disease (2012) 0.5 0.9 2.6 -0.3 1.6 -0.5 -0.4 -1.1
Mean Putamen Volume 1.2 1.4 5.3 0.2 0.0 2.3 1.1 -0.7
Fasting Glucose 0.3 0.3 1.3 -0.3 -0.3 1.1 0.1 0.2
HbA1C 0.4 0.5 1.3 -0.0 1.1 -0.8 0.1 0.7
HDL Cholesterol 0.1 0.2 0.5 0.7 0.3 0.3 0.1 0.3
LDL Cholesterol 0.1 0.2 0.4 -0.3 -0.4 -0.6 -0.6 -0.2
Lupus 1.7 2.6 5.8 2.4 -1.7 0.5 2.1 0.2
Neuroticism (2016) 0.4 0.5 2.2 0.1 1.5 -0.0 -0.2 0.7
Primary Biliary Cirrhosis 0.4 0.5 1.3 -0.8 -1.1 -0.6 0.1 0.5
Rheumatoid Arthritis 0.9 1.3 2.2 -1.5 -0.0 -0.8 -1.2 1.5
Schizophrenia (2014) 0.4 0.9 3.0 0.8 -0.1 -1.7 0.3 -1.0
Triglycerides 0.1 0.2 0.7 -0.8 -0.3 0.2 0.1 0.0
Type 2 Diabetes (T2D) (2012) 1.5 1.8 4.7 1.1 -0.3 2.2 1.4 -0.9
Ulcerative Colitis 0.2 0.4 1.3 0.4 0.1 0.5 1.1 0.2
Blood Eosinophil Count 0.2 1.9 3.5 1.5 -1.9 0.1 1.9 -0.5
Blood Platelet Count 0.4 4.9 14.3 3.8 -1.0 0.3 3.0 0.6
Blood Red Count 1.4 13.5 24.9 -4.4 2.6 -5.0 -3.8 1.5
Blood White Count 0.4 3.2 7.3 2.7 0.5 -0.5 1.9 -2.2
Heel T-Score 3.2 25.8 67.7 -8.2 1.1 -3.8 -6.1 2.8
BMI 1.0 6.1 14.4 3.0 -0.1 2.0 1.7 -3.8
Height 0.3 5.2 9.9 -3.1 2.2 -1.5 -3.0 0.1
Waist Hip Ratio (WHR) 0.4 1.9 4.2 2.0 -0.2 1.3 1.8 -0.4
Systolic Blood Pressure 0.1 0.4 0.6 -0.4 0.5 0.8 0.8 0.5
Smoking Status 2.4 5.8 11.2 3.3 0.4 2.1 2.7 -2.4
Allergy or Eczema 0.3 0.9 1.5 -0.6 -0.6 -1.1 -1.0 -1.2
Cardiovascular Disease 0.5 1.8 3.1 1.6 -1.2 0.2 1.8 -1.4
Hypothyroidism (self reported) 0.4 0.8 1.8 -0.4 1.1 -0.9 -1.4 0.3
Respiratory disease 0.0 0.0 0.1 -0.2 0.1 -0.3 -0.3 0.1
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.8 -1.0 0.1 -0.6 -1.3 -0.6
Lung FEV1/FVC ratio 0.7 3.6 12.1 1.4 -0.5 3.5 1.8 0.5
Lung FVC 0.1 0.3 1.0 0.5 0.2 -0.5 -0.2 1.0
Neuroticism 0.2 0.4 0.9 1.0 0.6 0.7 -0.3 0.3
Chronotype (morning person) 0.8 1.8 2.9 -1.7 -1.3 -1.6 -0.4 1.3
Hair Pigment 0.1 1.8 4.2 1.1 -1.0 1.1 2.0 1.1
Tanning 0.1 1.2 2.6 -0.9 -1.5 -1.6 -0.5 0.4
Hand grip strength (left) 0.0 0.1 0.4 -0.2 0.6 0.0 -0.4 0.0
Number of treatments/medications taken 0.9 1.6 7.7 0.3 -0.1 -0.2 -0.3 -2.8
Average weekly spirits intake 0.3 0.4 1.3 0.3 -1.1 0.2 -0.2 -0.7
Sensitivity / hurt feelings 0.5 0.9 3.0 -0.1 1.7 -0.5 -0.5 1.1
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.8 0.4 0.4 -0.9 0.2 0.1
Hearing difficulty/problems: Yes 1.9 2.9 7.6 -2.0 0.8 -0.4 -2.8 -1.4
Relative age of first facial hair 1.1 2.3 5.5 -1.0 0.7 -2.3 -2.1 0.5
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.4 0.2 -0.0 0.7 -0.3 -0.5
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.6 0.1 0.1 -0.8 0.0 -0.2
Ever had hysterectomy (womb removed) 0.4 0.4 0.8 -0.2 0.9 -0.6 -0.6 0.9
Systolic blood pressure, automated reading 0.1 0.3 0.8 -0.2 0.9 0.2 0.1 -0.8
Eye problems/disorders: Diabetes related eye disease 3.6 3.9 7.8 -1.8 1.4 -2.1 -2.8 1.6
Angina 2.5 3.3 8.3 -1.2 2.9 0.4 -2.5 -0.3
Medication for hormone replacement therapy 0.9 1.0 4.1 0.4 0.2 -2.0 -0.2 0.9
Vitamin and mineral supplements 1.1 1.5 4.2 -1.2 0.6 0.1 -1.1 2.0
Supplements: Zinc 0.9 1.0 2.3 -0.6 0.4 -1.5 -0.9 -1.1
Medication: Co-codamol 0.1 0.2 0.5 -0.5 0.1 -0.7 0.1 0.3
Medication: Metformin 0.7 1.0 1.5 -1.0 0.8 -0.4 -1.2 1.2
Diabetes (father) 0.7 0.9 3.7 -0.7 0.2 -1.9 -0.6 -0.1
Diabetes (mother) 1.0 1.2 2.6 0.5 -0.7 1.3 1.6 -1.0
Severe depression (siblings) 0.7 0.8 1.3 -0.4 0.8 -0.8 -1.0 -1.1
Pack years adult smoking proportion 3.3 5.1 9.4 2.6 0.9 3.1 2.1 -2.0
Impedance of leg (right) 0.1 0.5 1.0 -0.5 0.5 -0.9 0.4 1.0
Leg fat-free mass (left) 0.2 1.0 2.5 0.4 1.1 0.5 -0.8 -1.6
Trunk fat percentage 0.6 2.4 8.8 1.6 0.4 0.5 0.3 -3.0
Hand grip strength (right) 0.3 0.8 1.8 1.0 0.1 0.9 1.4 -0.1
Townsend deprivation index at recruitment 0.9 1.3 2.6 -1.2 -1.1 -1.1 0.0 1.6
Current tobacco smoking 4.2 6.9 12.2 3.5 1.0 2.5 2.5 -3.0
Average weekly fortified wine intake 0.7 0.8 1.9 -0.8 1.4 -0.1 -1.0 -0.8
Maternal smoking around birth 3.6 5.2 7.5 2.7 -0.7 2.7 2.2 -2.4
Fed-up feelings 0.4 0.8 2.1 1.5 0.4 1.1 0.5 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.1 -0.4 0.1 -0.1 0.2 0.2
Relative age voice broke 0.1 0.2 0.3 0.6 -0.0 -0.1 -0.5 0.5
Taking other prescription medications 1.3 2.0 4.3 -1.0 0.6 -1.2 -2.1 -1.6
Age when periods started (menarche) 0.1 0.2 0.7 -0.9 -0.1 -0.1 -0.2 0.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.0 1.0 -0.4 0.1 0.8 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.3 7.1 -2.5 0.8 -0.5 -1.4 2.7
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 5.3 2.3 -0.1 -0.0 0.8 0.3
Qualifications: CSEs or equivalent 0.8 1.0 3.1 0.1 -1.1 1.8 0.7 -0.6
Serious illness, injury or assault to yourself 0.6 0.7 1.6 -0.5 0.0 0.6 -1.3 -1.2
High blood pressure 0.5 1.4 2.7 1.6 -0.5 0.3 1.6 -1.3
Hayfever, allergic rhinitis or eczema 0.9 2.0 3.4 -1.6 0.0 -1.8 -1.9 -1.1
Multivitamins +/- minerals 0.4 0.5 1.4 0.3 -0.6 -0.4 0.7 -1.2
Stomach or abdominal pain in last month 0.5 0.7 2.7 0.6 1.6 -0.4 -0.0 0.2
Supplements: Glucosamine 1.1 1.5 3.4 1.0 -1.5 0.8 0.4 -1.8
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.6 -0.6 -1.3 -0.1 -0.4 -0.2
Medication: Atenolol 0.9 1.1 3.1 1.8 0.8 0.8 0.6 -0.9
Medication: Levothyroxine sodium 0.4 0.7 1.6 0.8 0.2 -1.3 -0.1 1.1
Sitting height 0.3 2.2 4.9 -1.5 1.9 0.2 -2.2 0.5
Chronic bronchitis/emphysema (father) 1.1 1.3 2.0 1.2 -0.5 1.2 1.4 -1.0
High blood pressure (mother) 0.1 0.2 0.5 -0.3 -0.2 -0.2 0.7 0.4
Body mass index (BMI) 0.7 2.9 8.4 2.0 0.0 1.2 0.8 -2.9
Impedance of leg (left) 0.1 0.4 0.7 -0.5 -0.1 -0.7 0.7 0.8
Leg predicted mass (left) 0.2 1.0 2.5 0.5 1.1 0.6 -0.6 -1.6
Trunk fat mass 0.5 2.3 8.9 1.4 0.4 0.8 0.3 -3.0
Waist circumference 0.8 3.1 6.2 2.2 0.3 1.8 1.1 -2.5
Number of incorrect matches in round 0.9 1.6 3.5 1.5 -1.3 0.2 0.5 -1.9
Past tobacco smoking 1.2 2.2 5.1 -2.3 0.4 -1.5 -1.4 1.2
Alcohol usually taken with meals 0.4 0.7 1.2 0.3 1.1 0.7 -0.8 -1.1
Nervous feelings 0.5 0.9 2.9 -0.9 0.3 -0.7 -1.7 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.3 -0.4 0.5 -0.1 -0.4 -0.0
Hearing difficulty/problems with background noise 0.9 1.4 3.4 0.1 1.8 1.2 -0.9 -1.2
Hair/balding pattern: Pattern 2 1.5 1.9 4.3 0.8 -2.1 2.0 0.5 -0.7
Had menopause 1.1 1.3 4.4 -0.3 1.1 -2.1 -0.8 -0.4
Had other major operations 1.5 1.8 3.2 1.8 0.6 1.6 1.7 -0.0
Forced vital capacity (FVC) 0.1 0.2 1.2 0.1 1.1 -0.0 -0.2 0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 4.1 -2.0 -0.1 -0.4 -0.9 2.0
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 3.3 0.1 -1.8 0.0 0.3 -1.6
Qualifications: None of the above 1.0 2.1 5.7 0.9 -1.9 0.1 2.4 0.5
Financial difficulties in last 2 years 1.2 1.6 3.1 1.6 1.8 1.0 0.6 -0.8
Mouth/teeth dental problems 0.6 0.9 1.9 0.5 -0.8 0.5 1.4 -1.2
Heart attack 0.8 1.0 1.9 1.4 1.3 0.5 0.2 -1.0
Allergy 0.4 1.0 2.7 0.3 0.1 1.6 1.2 0.9
Pain all over the body in last month 0.9 1.0 3.2 -0.5 1.8 -0.8 -0.9 -0.4
Diabetes (self-reported) 0.6 0.8 1.6 -1.2 -0.2 -0.7 -1.0 1.1
Hayfever/allergic rhinitis (self-reported) 1.5 1.9 4.3 -1.8 -0.2 -2.1 -1.5 0.2
Medication: Ramipril 0.7 0.9 1.7 1.3 0.3 1.1 0.4 -1.3
Medication: Simvastatin 0.9 1.3 2.7 1.6 0.2 0.9 0.4 -1.6
Fluid intelligence score 2.2 4.5 9.2 -1.6 2.3 -2.3 -3.0 -0.4
Illnesses of siblings 1.8 2.5 5.1 -2.2 -0.7 -1.2 -2.2 0.9
Neuroticism score 0.1 0.3 1.0 1.0 0.2 0.4 -0.2 -0.1
Weight 0.4 2.0 6.4 1.3 0.7 1.2 0.3 -2.5
Impedance of arm (right) 0.0 0.1 0.4 0.2 -0.6 -0.3 0.1 0.4
Arm fat percentage (right) 0.7 2.9 9.1 2.1 -0.4 0.7 0.6 -3.0
Trunk fat-free mass 0.1 0.5 1.0 0.0 0.9 0.6 -0.5 -1.0
Hip circumference 0.3 1.3 4.2 1.0 1.0 0.7 -0.1 -2.1
Time employed in main current job 0.1 0.1 0.2 -0.1 0.4 0.1 0.1 0.3
Alcohol intake versus 10 years previously 0.0 0.0 0.1 -0.1 0.3 -0.0 -0.1 0.3
Father’s age at death 0.8 1.0 2.2 -0.9 1.5 -0.4 -1.3 0.3
Worrier / anxious feelings 0.3 0.6 2.0 0.5 -0.8 -0.1 0.2 1.4
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 4.0 -0.1 -0.9 1.7 0.3 -2.0
Falls in the last year 0.8 1.1 1.8 0.7 -1.1 1.3 1.3 0.2
Hair/balding pattern: Pattern 3 0.5 0.7 1.2 -1.1 1.0 -0.6 -0.4 -1.0
Number of live births 0.2 0.3 1.3 -0.2 1.1 0.3 0.1 -0.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.7 0.3 0.2 0.9 0.5 0.5
Pulse rate 0.9 1.4 5.8 -0.3 2.4 0.4 -0.1 -1.1
Happiness 2.5 3.0 8.7 0.5 -3.0 1.5 0.3 -1.9
Noisy workplace 1.1 1.3 2.7 1.6 -0.2 0.2 1.6 -1.1
Qualifications: A levels/AS levels or equivalent 0.8 1.8 5.3 0.9 2.3 1.2 -0.7 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.7 -1.3 -0.0 0.5 -0.5 1.2
Mouth/teeth dental problems: Dentures 0.4 0.7 1.3 -0.5 1.1 -1.1 -0.7 0.4
Asthma 0.1 0.2 0.3 0.5 -0.2 -0.6 -0.4 -0.4
Medication: Ibuprofen (e.g. Nurofen) 4.6 5.8 11.6 2.9 -0.8 3.4 2.7 -1.2
Medication: Cholesterol lowering 0.9 1.3 4.0 1.1 -0.5 0.6 0.9 -2.0
Depression (self-reported) 0.8 1.0 1.7 -1.1 -0.0 -1.3 -1.2 -0.7
Medication: Lansoprazole 1.1 1.3 2.8 0.4 -1.7 1.0 1.4 0.9
Prospective memory result 0.5 0.6 1.4 -0.2 -1.2 -0.3 1.0 -0.6
Lung cancer (father) 1.4 1.6 3.9 1.3 -0.9 2.0 1.3 -0.1
Illnesses of mother 0.4 0.5 1.7 0.5 -1.3 -0.7 -0.3 0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.1 0.1 -0.0 1.0 0.2 0.8
Pulse wave Arterial Stiffness index 0.6 0.7 2.4 0.1 1.5 -1.1 0.0 -0.2
Impedance of arm (left) 0.1 0.3 0.7 -0.6 0.4 -0.8 -0.6 0.1
Arm fat mass (right) 0.6 2.7 9.0 1.9 -0.0 0.8 0.5 -3.0
Trunk predicted mass 0.1 0.5 1.1 0.1 1.0 0.6 -0.5 -1.0
Standing height 0.2 1.7 2.9 -1.7 1.7 0.1 -1.5 0.5
Length of working week for main job 1.7 1.9 3.9 2.0 0.6 1.4 1.6 0.9
Exposure to tobacco smoke at home 0.2 0.2 0.7 -0.8 0.1 -0.3 0.3 0.2
Breastfed as a baby 2.6 3.3 10.3 0.4 -1.5 -1.0 1.5 3.2
Tense / ‘highly strung’ 1.2 2.0 4.5 -0.4 2.1 -1.8 -1.5 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 5.8 -2.3 0.3 -1.6 -2.4 -0.5
Hair/balding pattern: Pattern 4 0.4 1.1 2.0 -1.4 0.8 -1.0 -1.0 0.9
Birth weight of first child 0.1 0.2 0.6 -0.5 0.7 0.4 -0.4 -0.2
Peak expiratory flow (PEF) 0.1 0.3 1.0 -0.1 -0.3 1.0 0.7 -0.0
Pulse wave reflection index 0.5 0.7 2.1 1.0 -0.1 -1.4 0.3 0.5
Ever highly irritable/argumentative for 2 days 0.5 0.5 2.6 0.2 -1.6 0.0 0.2 0.3
Loud music exposure frequency 0.7 0.8 1.7 1.3 -1.3 -0.6 0.1 -0.1
Qualifications: O levels/GCSEs or equivalent 1.9 3.0 6.8 -1.3 2.6 -0.2 -2.5 -0.1
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 4.3 -0.8 -0.2 0.2 -1.1 2.1
Blood clot in the leg (DVT) 0.7 0.9 2.4 0.8 -1.6 -1.0 0.5 -0.6
Medication: Paracetamol 1.6 2.7 6.3 1.1 -0.7 2.5 2.2 -0.9
Headache pain in last month 0.2 0.3 0.8 0.9 -0.5 0.2 0.7 -0.1
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.5 -0.3 1.0 -0.5 -0.9 1.2
Glaucoma (self-reported) 0.5 0.6 1.2 -0.6 0.6 -0.0 -1.1 -0.9
Gout (self-reported) 0.3 0.4 1.6 0.4 0.2 0.1 -0.3 -1.3
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 1.7 -0.7 0.5 -1.3 -1.2 1.1
Medication: Amlodipine 0.9 1.2 3.9 -0.5 0.5 -2.0 -0.2 1.2
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.1 -0.1 0.1 -0.4 0.4
Birth weight 0.4 0.8 1.3 0.9 -0.9 1.1 1.1 0.4
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.6 0.6 -0.6 -0.3 0.8 -0.4
High blood pressure (siblings) 1.3 1.8 5.4 1.4 -0.6 1.2 2.3 0.0
Forced vital capacity (FVC), Best measure 0.0 0.1 0.2 0.2 0.3 0.4 -0.2 0.5
Body fat percentage 0.7 2.9 9.8 1.9 0.4 0.7 0.6 -3.1
Leg fat percentage (right) 0.7 2.6 8.1 1.9 0.4 0.6 0.7 -2.9
Arm fat-free mass (right) 0.2 0.8 2.5 -0.1 1.6 0.4 -0.6 -1.1
Exposure to tobacco smoke outside home 0.4 0.6 1.2 0.5 1.0 -0.7 0.2 -1.1
Comparative body size at age 10 0.4 1.0 2.8 0.1 -1.2 1.7 0.6 -0.7
Number of full brothers 0.9 1.2 3.6 -0.5 0.9 -1.1 -0.1 1.9
Worry too long after embarrassment 0.9 1.5 4.9 0.4 1.0 2.2 0.8 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.6 -1.6 0.0 -0.5 -1.3 -0.9
Wheeze or whistling in the chest in last year 2.5 4.5 9.6 3.1 0.5 1.4 1.0 -3.1
Number of children fathered 2.3 2.6 6.0 -1.0 2.1 -0.1 -2.4 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 1.7 1.9 6.1 -0.6 -2.5 0.3 0.5 1.7
Age at first live birth 1.1 1.9 3.5 1.7 -1.0 0.6 1.9 1.3
Pulse wave peak to peak time 0.6 0.7 1.9 -0.2 -1.4 1.2 -0.1 0.4
Health satisfaction 2.0 2.6 6.0 1.1 -2.4 1.4 1.0 -1.7
Shortness of breath walking on level ground 0.6 0.7 1.6 0.0 -1.1 1.3 0.3 -0.8
Qualifications: College or University degree 0.1 0.5 1.4 1.2 0.9 -0.0 0.1 -0.3
Eye problems/disorders: None of the above 1.5 1.8 4.4 0.8 -0.7 1.2 2.1 1.4
Mouth/teeth dental problems: Loose teeth 1.7 2.1 5.2 -0.1 2.3 -0.9 -1.3 -1.7
Emphysema/chronic bronchitis 0.2 0.2 0.3 -0.4 0.6 0.2 0.3 -0.5
Medication for pain relief, constipation, heartburn 2.2 3.7 7.6 -2.0 -0.4 -2.8 -1.5 2.2
Neck or shoulder pain in last month 0.5 0.8 1.7 -1.2 0.1 -0.8 -1.3 0.1
Medication: Blood pressure 0.1 0.2 0.8 0.2 0.3 0.5 0.2 -0.9
Angina (self-reported) 2.1 2.8 6.7 -1.1 2.6 0.2 -2.4 -0.4
Migraine (self-reported) 0.6 0.7 2.5 -0.1 0.4 0.1 -0.9 -1.6
Medication: Ibuprofen 3.7 4.4 7.4 2.5 -1.0 2.7 2.5 -1.1
Medication: Allopurinol 0.3 0.4 0.9 -0.3 0.7 -0.3 -0.7 -0.9
Medication: Omeprazole 0.2 0.3 0.9 0.5 0.2 0.3 -0.5 -0.9
Medication: Seretide 50 evohaler 0.8 0.9 2.2 0.5 -0.1 1.4 0.4 -1.5
Mean time to correctly identify matches 0.3 0.6 1.1 0.8 -0.3 1.1 1.0 -0.1
Heart disease (mother) 2.0 2.4 7.7 0.0 2.8 -0.9 -0.7 -1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 2.7 1.3 -0.5 1.6 0.8 -1.3
Whole body fat mass 0.6 2.6 8.8 1.7 0.5 0.9 0.5 -3.0
Leg fat mass (right) 0.8 2.9 9.2 1.8 0.5 1.1 0.7 -3.0
Arm predicted mass (right) 0.2 0.8 2.4 -0.4 1.5 0.2 -0.8 -1.0
Pulse rate, automated reading 0.3 0.9 2.1 -0.1 1.0 1.1 0.4 -1.5
Alcohol intake frequency. 0.5 1.3 3.4 -0.8 -0.8 -1.2 -0.4 1.9
Comparative height size at age 10 0.1 0.6 1.9 0.4 1.4 0.4 0.4 0.7
Number of full sisters 0.6 0.7 1.4 0.3 -1.2 0.8 1.1 -0.5
Suffer from ‘nerves’ 0.8 1.3 3.8 -0.5 -0.2 -2.0 -1.2 0.9
Overall health rating 0.8 1.8 4.6 1.0 -0.2 1.7 0.8 -2.1
Chest pain or discomfort 0.4 0.6 1.8 0.4 1.4 0.2 -0.8 0.1
Had major operations 0.9 1.1 2.1 1.2 1.1 0.5 -0.7 -1.4
Age at last live birth 2.3 3.3 6.9 2.4 -0.8 1.8 2.6 0.5
Family relationship satisfaction 0.6 0.7 3.5 -0.1 -1.9 -0.2 -0.2 -0.0
Leg pain on walking 0.3 0.4 1.0 -0.2 -0.5 -0.9 0.2 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.6 0.1 -0.9 0.8 0.5 -1.2
Commuting to job workplace: Car/motor vehicle 1.9 2.2 5.8 0.8 0.9 1.6 1.1 -2.4
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.9 -0.2 0.3 -0.2 -0.2 -0.9
Medication: Aspirin 0.4 0.5 1.1 0.7 1.0 0.5 0.1 -1.0
Supplements: Vitamin C 0.3 0.4 1.3 1.1 -0.5 0.3 0.3 -0.4
Knee pain experienced in last month 1.6 2.5 7.6 2.8 0.4 1.4 1.6 -0.7
Hypertension (Self-reported) 0.5 1.5 2.8 1.7 -0.5 0.1 1.7 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.3 0.4 -1.0 1.2 0.4 -0.2
Illnesses of father: Heart disease 0.6 0.9 2.4 -0.3 0.3 1.5 0.4 -1.3
Illnesses of siblings: Diabetes 0.9 1.1 4.4 -0.0 0.9 0.7 -0.3 -2.1
Smoking status: Previous 0.4 0.6 2.1 0.5 -1.4 0.7 0.4 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.7 -0.3 -0.6 1.3 -0.1 0.4
Whole body fat-free mass 0.1 0.7 1.6 0.1 1.1 0.6 -0.6 -1.3
Leg fat-free mass (right) 0.1 0.8 2.1 0.3 0.9 0.6 -0.6 -1.4
Arm fat percentage (left) 0.8 3.0 11.2 1.8 0.1 0.6 0.3 -3.4
Average weekly red wine intake 0.2 0.3 0.5 -0.5 0.6 0.7 0.1 -0.7
Handedness (chirality/laterality): Left-handed 5.9 7.1 12.3 -3.3 2.8 -1.9 -3.5 1.0
Mood swings 0.4 0.7 1.9 1.0 0.2 1.4 0.3 0.5
Loneliness, isolation 0.2 0.3 0.7 -0.4 -0.6 -0.3 -0.5 0.9
Long-standing illness, disability or infirmity 0.3 0.5 1.1 -0.5 0.0 0.7 -1.1 -0.7
Ever had bowel cancer screening 0.4 0.4 1.6 0.4 1.3 -0.2 -0.7 -0.2
Diabetes diagnosed by doctor 0.5 0.8 1.3 -1.0 -0.7 -0.7 -0.8 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.8 -0.5 -0.1 0.5 0.9 1.3
Friendships satisfaction 1.8 2.3 9.6 -0.8 -3.1 0.3 0.8 -0.5
Qualifications: nursing, teaching 1.3 2.1 7.7 -0.0 2.8 0.7 -1.1 -1.0
Commuting to job workplace: Walk 0.1 0.1 0.3 0.3 -0.3 -0.5 0.1 0.2
Eye problems/disorders: Cataract 0.7 0.9 2.2 -0.4 1.5 -0.2 -1.3 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.3 0.2 0.7 0.3 -0.8 -1.5
Medication for cholesterol 0.6 0.9 3.9 -0.2 -0.2 2.0 0.7 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.0 1.0 0.8 0.5 0.3 -0.1
Back pain experienced in last month 0.1 0.1 0.2 -0.2 -0.3 0.1 -0.5 0.2
Mineral and other dietary supplements 1.8 2.4 6.4 -2.1 0.0 -0.5 -0.7 2.5
Breast cancer (self-reported) 2.2 2.6 7.6 1.4 -0.7 2.8 1.7 0.2
Asthma (self-reported) 0.1 0.2 0.6 0.4 0.0 -0.8 -0.5 -0.1
Osteoporosis (self-reported) 0.8 1.0 3.0 0.7 0.7 0.9 0.5 -1.7
Osteoarthritis (self-reported) 0.7 1.0 3.2 0.2 1.0 -0.4 -0.7 -1.8
Medication: Aspirin 0.4 0.6 1.2 1.1 0.7 0.5 0.3 -0.9
Medication: Gliclazide 0.7 0.8 1.8 1.4 -1.3 -0.1 0.6 -0.4
Illnesses of father: None of the above (group 1) 0.6 0.7 2.0 -0.5 -0.5 -1.4 -0.7 0.8
Smoking status: Current 3.7 5.8 9.8 3.1 1.4 1.9 2.3 -2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.7 0.2 -0.9 1.2 0.8 -1.3
Whole body water mass 0.1 0.6 1.5 0.1 1.0 0.6 -0.6 -1.2
Leg predicted mass (right) 0.1 0.8 2.3 0.4 0.8 0.6 -0.6 -1.5
Arm fat mass (left) 0.6 2.4 8.6 1.7 0.3 0.7 0.3 -2.9
Number of self-reported non-cancer illnesses 1.0 1.8 7.6 1.0 -0.5 -0.2 0.0 -2.8
Average weekly champagne plus white wine intake 0.4 0.5 0.9 0.7 0.5 -1.0 -0.8 -0.5
Miserableness 1.2 2.0 7.0 1.1 0.4 2.6 0.4 -1.2
Guilty feelings 0.6 0.9 2.6 -0.4 1.6 -0.8 -1.0 0.6
Wears glasses or contact lenses 0.7 0.8 2.0 0.5 0.8 -0.9 -0.1 -1.4
Ever taken oral contraceptive pill 1.2 1.4 3.7 0.8 -0.6 1.4 0.4 -1.9
Hearing aid user 0.3 0.3 0.9 -0.2 -1.0 -0.5 -0.7 0.0
Mother’s age at death 2.3 2.9 6.1 -2.5 -0.1 -0.9 -2.0 1.9
Financial situation satisfaction 0.8 1.0 2.1 0.5 -0.3 1.5 -1.2 -1.0
Tinnitus: Yes, now most or all of the time 1.6 1.9 4.5 -2.1 0.6 -1.7 -0.9 -0.9
Commuting to job workplace: Public transport 1.0 1.1 3.0 -1.0 -0.2 -1.1 -1.7 0.7
Eye problems/disorders: Glaucoma 0.4 0.5 1.0 0.3 0.7 -0.7 -0.6 -1.0
Medication: Blood pressure 0.2 0.5 1.9 0.3 0.3 -1.4 -0.3 -0.2
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 -0.1 0.3 0.1 -0.4 -0.2
Supplements: Fish oil (including cod liver oil) 2.8 3.7 8.7 3.0 1.5 0.4 1.2 -2.4
High cholesterol (Self-reported) 0.9 1.7 2.5 1.6 -1.4 1.2 1.6 0.4
Medication: Bendroflumethiazide 0.9 1.4 4.1 -1.2 0.1 -0.9 -2.0 -0.9
Medication: Paracetamol 1.9 3.0 7.7 1.1 -0.2 2.8 2.3 -0.8
Medication: Lisinopril 2.1 2.7 6.9 -0.4 -2.6 1.1 2.0 -1.1
Medication: Atorvastatin 0.6 0.8 2.6 -0.2 -1.6 0.1 0.7 -0.8
Illnesses of father: High blood pressure 0.7 0.8 1.9 1.1 1.1 -0.0 1.4 -0.1
Alcohol drinker status: Never 0.6 0.8 2.5 0.4 -0.6 -0.7 0.5 1.6
Ever smoked 1.7 2.9 6.3 2.5 0.8 1.9 1.4 -1.3
Basal metabolic rate 0.2 1.0 2.9 0.5 1.0 0.8 -0.4 -1.7
Leg fat percentage (left) 0.8 2.8 8.6 2.0 0.1 0.8 0.9 -2.9
Arm fat-free mass (left) 0.1 0.5 1.1 0.4 1.0 0.6 -0.2 -1.0
Number of operations (self-reported) 0.2 0.3 0.6 0.8 0.6 -0.6 -0.1 -0.3
Average weekly beer plus cider intake 1.3 1.8 5.1 1.0 -2.3 1.1 1.2 -0.7
Irritability 0.8 1.4 3.3 0.8 -1.8 1.4 0.7 -0.8
Risk taking 1.2 1.7 4.6 -0.4 1.0 -1.2 -2.1 -1.1
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.3 -1.1 -0.8 0.6 -0.4 -0.5
Fractured/broken bones in last 5 years 0.8 1.1 1.7 -0.8 -1.1 -1.0 -1.3 -0.9
Age started oral contraceptive pill 1.4 1.7 4.5 -0.6 2.1 -1.3 -1.2 0.9
Diastolic blood pressure, automated reading 0.6 1.8 4.4 2.1 0.6 1.1 1.6 -0.8
Ever depressed for a whole week 0.4 0.5 1.9 -0.1 -1.4 -0.5 0.1 0.5
Unable to work because of sickness or disability 2.1 2.7 6.5 1.4 -1.1 2.5 1.0 -1.8
Commuting to job workplace: Cycle 0.6 0.8 2.9 1.7 -0.1 -0.2 1.0 0.0
Myopia 5.3 7.6 16.1 -1.6 2.4 -3.7 -4.0 -0.3
Vascular/heart problems diagnosed by doctor 0.6 1.7 3.2 -1.8 0.3 -0.5 -1.5 1.6
Cholesterol lowering medication 0.1 0.2 0.5 0.7 0.4 0.5 0.1 -0.4
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 3.4 1.3 -0.3 1.4 0.5 -1.8
Pain experienced in last month 0.5 0.8 2.2 0.2 -1.1 0.5 1.5 0.1
Supplements: Calcium 0.5 0.6 2.2 1.5 -0.7 -0.0 0.4 0.3
Basal cell carcinoma (self-reported) 1.0 1.2 3.5 -1.0 -0.8 -1.9 -0.9 0.4
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.8 1.1 1.7 0.3 -0.1 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.1 0.8 -1.4 -1.1 0.7 -0.0
Heart disease (siblings) 0.4 0.5 1.0 0.5 1.0 0.3 0.9 -0.5
Alcohol drinker status: Previous 3.0 3.4 7.1 -2.0 2.3 -0.7 -2.7 -0.7
Pack years of smoking 2.6 3.8 7.3 2.1 1.2 2.7 1.7 -1.7
Impedance of whole body 0.1 0.3 0.9 -0.6 0.1 -1.0 -0.1 0.5
Leg fat mass (left) 0.8 2.9 9.2 1.8 0.5 1.2 0.7 -3.0
Arm predicted mass (left) 0.1 0.6 1.4 0.3 1.2 0.6 -0.3 -0.9