Hub : Genes

NOS1AP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.163	0.0560	0.00086	0.045	NA	0.014	NA	0.039	2.0e-03	NA	5.4e-02	NA	3.8e-03
2	GTEx	Testis	0.227	0.0910	0.00700	0.179	NA	0.130	NA	0.021	2.2e-08	NA	2.3e-06	NA	4.0e-02
3	METSIM	Adipose	0.052	0.0196	0.00031	0.048	0.020	0.031	0.026	0.033	9.7e-08	0.00047	1.9e-05	6.7e-05	8.4e-06
4	TCGA	Colon Adenocarcinoma	0.073	0.0360	0.00750	-0.002	0.001	-0.004	NA	-0.005	4.5e-01	0.27000	7.1e-01	NA	8.9e-01
5	TCGA	Thyroid Carcinoma	0.126	0.0540	0.00230	0.034	0.022	0.052	NA	0.060	2.6e-04	0.00270	7.4e-06	NA	1.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.2	5.5	2.3	-0.5	0.4	0.3	-0.5
Bipolar Disorder or Schizophrenia	0.4	1.1	2.3	1.4	0.3	-1.0	-0.1	-1.5
Depressed Affect (Nagel 2018)	0.4	0.9	1.6	1.1	1.2	1.2	0.3	-0.2
Depression (Nagel 2018)	0.3	0.4	1.1	1.1	0.3	0.4	0.7	-0.3
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.9	-0.4	1.5	-1.3	-1.7	-1.0
Neuroticism (Nagel 2018)	0.4	1.0	3.3	0.8	1.8	0.5	-0.3	0.8
Schizophrenia (2018)	0.5	1.1	2.4	-0.1	0.7	-1.5	-0.4	-1.6
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.2	0.4	0.0	0.2	0.4
Worry (Nagel 2018)	0.4	0.8	1.9	0.6	1.4	-0.7	-0.8	0.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.4	-0.2	0.1	0.7	-1.0	-1.2
Alzheimer’s Disease (in father)	1.4	1.5	3.4	1.8	-1.1	0.8	1.5	0.3
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	0.2	0.1	1.0	-0.7	-1.2
Crohns Disease (2017)	1.0	2.2	3.9	-1.2	1.4	-1.4	-2.0	-1.4
Irritable Bowel Disease (IBD)	0.6	1.4	3.6	-0.4	1.1	-1.1	-0.9	-1.9
Ulcerative Colitis (UC)	0.4	0.8	2.9	0.5	0.1	-0.6	0.6	-1.7
Major Depression (MDD)	1.5	1.8	3.6	-1.5	0.5	-1.9	-1.3	1.2
Reaction Time	1.4	2.7	4.5	1.5	-1.2	2.1	1.9	-1.3
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.6	-0.9	1.5	-1.5	-2.1	-0.9
Breast Cancer	0.9	2.2	6.4	-1.0	1.7	-2.5	-0.6	0.3
Ovarian Cancer	1.0	1.3	3.4	-1.9	-0.9	-0.6	-1.3	-0.0
Prostate Cancer	1.2	1.6	2.5	-1.6	-0.3	-1.4	-1.1	1.5
Age at First Birth	0.9	1.3	2.1	1.4	-1.1	1.0	1.4	0.5
Bipolar Disorder (2011)	0.8	0.8	2.5	1.6	0.7	0.0	1.0	0.2
Body Mass Index (BMI) (2010)	4.4	6.0	9.4	2.7	-2.4	3.1	2.7	0.0
Coronary Artery Disease (CAD)	0.3	0.4	1.0	-0.6	-1.0	0.7	-0.1	0.1
Crohns Disease (2012)	0.5	0.9	2.6	-0.3	1.6	-0.5	-0.4	-1.1
Mean Putamen Volume	1.2	1.4	5.3	0.2	0.0	2.3	1.1	-0.7
Fasting Glucose	0.3	0.3	1.3	-0.3	-0.3	1.1	0.1	0.2
HbA1C	0.4	0.5	1.3	-0.0	1.1	-0.8	0.1	0.7
HDL Cholesterol	0.1	0.2	0.5	0.7	0.3	0.3	0.1	0.3
LDL Cholesterol	0.1	0.2	0.4	-0.3	-0.4	-0.6	-0.6	-0.2
Lupus	1.7	2.6	5.8	2.4	-1.7	0.5	2.1	0.2
Neuroticism (2016)	0.4	0.5	2.2	0.1	1.5	-0.0	-0.2	0.7
Primary Biliary Cirrhosis	0.4	0.5	1.3	-0.8	-1.1	-0.6	0.1	0.5
Rheumatoid Arthritis	0.9	1.3	2.2	-1.5	-0.0	-0.8	-1.2	1.5
Schizophrenia (2014)	0.4	0.9	3.0	0.8	-0.1	-1.7	0.3	-1.0
Triglycerides	0.1	0.2	0.7	-0.8	-0.3	0.2	0.1	0.0
Type 2 Diabetes (T2D) (2012)	1.5	1.8	4.7	1.1	-0.3	2.2	1.4	-0.9
Ulcerative Colitis	0.2	0.4	1.3	0.4	0.1	0.5	1.1	0.2
Blood Eosinophil Count	0.2	1.9	3.5	1.5	-1.9	0.1	1.9	-0.5
Blood Platelet Count	0.4	4.9	14.3	3.8	-1.0	0.3	3.0	0.6
Blood Red Count	1.4	13.5	24.9	-4.4	2.6	-5.0	-3.8	1.5
Blood White Count	0.4	3.2	7.3	2.7	0.5	-0.5	1.9	-2.2
Heel T-Score	3.2	25.8	67.7	-8.2	1.1	-3.8	-6.1	2.8
BMI	1.0	6.1	14.4	3.0	-0.1	2.0	1.7	-3.8
Height	0.3	5.2	9.9	-3.1	2.2	-1.5	-3.0	0.1
Waist Hip Ratio (WHR)	0.4	1.9	4.2	2.0	-0.2	1.3	1.8	-0.4
Systolic Blood Pressure	0.1	0.4	0.6	-0.4	0.5	0.8	0.8	0.5
Smoking Status	2.4	5.8	11.2	3.3	0.4	2.1	2.7	-2.4
Allergy or Eczema	0.3	0.9	1.5	-0.6	-0.6	-1.1	-1.0	-1.2
Cardiovascular Disease	0.5	1.8	3.1	1.6	-1.2	0.2	1.8	-1.4
Hypothyroidism (self reported)	0.4	0.8	1.8	-0.4	1.1	-0.9	-1.4	0.3
Respiratory disease	0.0	0.0	0.1	-0.2	0.1	-0.3	-0.3	0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.8	-1.0	0.1	-0.6	-1.3	-0.6
Lung FEV1/FVC ratio	0.7	3.6	12.1	1.4	-0.5	3.5	1.8	0.5
Lung FVC	0.1	0.3	1.0	0.5	0.2	-0.5	-0.2	1.0
Neuroticism	0.2	0.4	0.9	1.0	0.6	0.7	-0.3	0.3
Chronotype (morning person)	0.8	1.8	2.9	-1.7	-1.3	-1.6	-0.4	1.3
Hair Pigment	0.1	1.8	4.2	1.1	-1.0	1.1	2.0	1.1
Tanning	0.1	1.2	2.6	-0.9	-1.5	-1.6	-0.5	0.4
Hand grip strength (left)	0.0	0.1	0.4	-0.2	0.6	0.0	-0.4	0.0
Number of treatments/medications taken	0.9	1.6	7.7	0.3	-0.1	-0.2	-0.3	-2.8
Average weekly spirits intake	0.3	0.4	1.3	0.3	-1.1	0.2	-0.2	-0.7
Sensitivity / hurt feelings	0.5	0.9	3.0	-0.1	1.7	-0.5	-0.5	1.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.8	0.4	0.4	-0.9	0.2	0.1
Hearing difficulty/problems: Yes	1.9	2.9	7.6	-2.0	0.8	-0.4	-2.8	-1.4
Relative age of first facial hair	1.1	2.3	5.5	-1.0	0.7	-2.3	-2.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.2	-0.0	0.7	-0.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.6	0.1	0.1	-0.8	0.0	-0.2
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	-0.2	0.9	-0.6	-0.6	0.9
Systolic blood pressure, automated reading	0.1	0.3	0.8	-0.2	0.9	0.2	0.1	-0.8
Eye problems/disorders: Diabetes related eye disease	3.6	3.9	7.8	-1.8	1.4	-2.1	-2.8	1.6
Angina	2.5	3.3	8.3	-1.2	2.9	0.4	-2.5	-0.3
Medication for hormone replacement therapy	0.9	1.0	4.1	0.4	0.2	-2.0	-0.2	0.9
Vitamin and mineral supplements	1.1	1.5	4.2	-1.2	0.6	0.1	-1.1	2.0
Supplements: Zinc	0.9	1.0	2.3	-0.6	0.4	-1.5	-0.9	-1.1
Medication: Co-codamol	0.1	0.2	0.5	-0.5	0.1	-0.7	0.1	0.3
Medication: Metformin	0.7	1.0	1.5	-1.0	0.8	-0.4	-1.2	1.2
Diabetes (father)	0.7	0.9	3.7	-0.7	0.2	-1.9	-0.6	-0.1
Diabetes (mother)	1.0	1.2	2.6	0.5	-0.7	1.3	1.6	-1.0
Severe depression (siblings)	0.7	0.8	1.3	-0.4	0.8	-0.8	-1.0	-1.1
Pack years adult smoking proportion	3.3	5.1	9.4	2.6	0.9	3.1	2.1	-2.0
Impedance of leg (right)	0.1	0.5	1.0	-0.5	0.5	-0.9	0.4	1.0
Leg fat-free mass (left)	0.2	1.0	2.5	0.4	1.1	0.5	-0.8	-1.6
Trunk fat percentage	0.6	2.4	8.8	1.6	0.4	0.5	0.3	-3.0
Hand grip strength (right)	0.3	0.8	1.8	1.0	0.1	0.9	1.4	-0.1
Townsend deprivation index at recruitment	0.9	1.3	2.6	-1.2	-1.1	-1.1	0.0	1.6
Current tobacco smoking	4.2	6.9	12.2	3.5	1.0	2.5	2.5	-3.0
Average weekly fortified wine intake	0.7	0.8	1.9	-0.8	1.4	-0.1	-1.0	-0.8
Maternal smoking around birth	3.6	5.2	7.5	2.7	-0.7	2.7	2.2	-2.4
Fed-up feelings	0.4	0.8	2.1	1.5	0.4	1.1	0.5	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	-0.4	0.1	-0.1	0.2	0.2
Relative age voice broke	0.1	0.2	0.3	0.6	-0.0	-0.1	-0.5	0.5
Taking other prescription medications	1.3	2.0	4.3	-1.0	0.6	-1.2	-2.1	-1.6
Age when periods started (menarche)	0.1	0.2	0.7	-0.9	-0.1	-0.1	-0.2	0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.0	1.0	-0.4	0.1	0.8	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.3	7.1	-2.5	0.8	-0.5	-1.4	2.7
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	5.3	2.3	-0.1	-0.0	0.8	0.3
Qualifications: CSEs or equivalent	0.8	1.0	3.1	0.1	-1.1	1.8	0.7	-0.6
Serious illness, injury or assault to yourself	0.6	0.7	1.6	-0.5	0.0	0.6	-1.3	-1.2
High blood pressure	0.5	1.4	2.7	1.6	-0.5	0.3	1.6	-1.3
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.4	-1.6	0.0	-1.8	-1.9	-1.1
Multivitamins +/- minerals	0.4	0.5	1.4	0.3	-0.6	-0.4	0.7	-1.2
Stomach or abdominal pain in last month	0.5	0.7	2.7	0.6	1.6	-0.4	-0.0	0.2
Supplements: Glucosamine	1.1	1.5	3.4	1.0	-1.5	0.8	0.4	-1.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.6	-0.6	-1.3	-0.1	-0.4	-0.2
Medication: Atenolol	0.9	1.1	3.1	1.8	0.8	0.8	0.6	-0.9
Medication: Levothyroxine sodium	0.4	0.7	1.6	0.8	0.2	-1.3	-0.1	1.1
Sitting height	0.3	2.2	4.9	-1.5	1.9	0.2	-2.2	0.5
Chronic bronchitis/emphysema (father)	1.1	1.3	2.0	1.2	-0.5	1.2	1.4	-1.0
High blood pressure (mother)	0.1	0.2	0.5	-0.3	-0.2	-0.2	0.7	0.4
Body mass index (BMI)	0.7	2.9	8.4	2.0	0.0	1.2	0.8	-2.9
Impedance of leg (left)	0.1	0.4	0.7	-0.5	-0.1	-0.7	0.7	0.8
Leg predicted mass (left)	0.2	1.0	2.5	0.5	1.1	0.6	-0.6	-1.6
Trunk fat mass	0.5	2.3	8.9	1.4	0.4	0.8	0.3	-3.0
Waist circumference	0.8	3.1	6.2	2.2	0.3	1.8	1.1	-2.5
Number of incorrect matches in round	0.9	1.6	3.5	1.5	-1.3	0.2	0.5	-1.9
Past tobacco smoking	1.2	2.2	5.1	-2.3	0.4	-1.5	-1.4	1.2
Alcohol usually taken with meals	0.4	0.7	1.2	0.3	1.1	0.7	-0.8	-1.1
Nervous feelings	0.5	0.9	2.9	-0.9	0.3	-0.7	-1.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	-0.4	0.5	-0.1	-0.4	-0.0
Hearing difficulty/problems with background noise	0.9	1.4	3.4	0.1	1.8	1.2	-0.9	-1.2
Hair/balding pattern: Pattern 2	1.5	1.9	4.3	0.8	-2.1	2.0	0.5	-0.7
Had menopause	1.1	1.3	4.4	-0.3	1.1	-2.1	-0.8	-0.4
Had other major operations	1.5	1.8	3.2	1.8	0.6	1.6	1.7	-0.0
Forced vital capacity (FVC)	0.1	0.2	1.2	0.1	1.1	-0.0	-0.2	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.1	-2.0	-0.1	-0.4	-0.9	2.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.3	0.1	-1.8	0.0	0.3	-1.6
Qualifications: None of the above	1.0	2.1	5.7	0.9	-1.9	0.1	2.4	0.5
Financial difficulties in last 2 years	1.2	1.6	3.1	1.6	1.8	1.0	0.6	-0.8
Mouth/teeth dental problems	0.6	0.9	1.9	0.5	-0.8	0.5	1.4	-1.2
Heart attack	0.8	1.0	1.9	1.4	1.3	0.5	0.2	-1.0
Allergy	0.4	1.0	2.7	0.3	0.1	1.6	1.2	0.9
Pain all over the body in last month	0.9	1.0	3.2	-0.5	1.8	-0.8	-0.9	-0.4
Diabetes (self-reported)	0.6	0.8	1.6	-1.2	-0.2	-0.7	-1.0	1.1
Hayfever/allergic rhinitis (self-reported)	1.5	1.9	4.3	-1.8	-0.2	-2.1	-1.5	0.2
Medication: Ramipril	0.7	0.9	1.7	1.3	0.3	1.1	0.4	-1.3
Medication: Simvastatin	0.9	1.3	2.7	1.6	0.2	0.9	0.4	-1.6
Fluid intelligence score	2.2	4.5	9.2	-1.6	2.3	-2.3	-3.0	-0.4
Illnesses of siblings	1.8	2.5	5.1	-2.2	-0.7	-1.2	-2.2	0.9
Neuroticism score	0.1	0.3	1.0	1.0	0.2	0.4	-0.2	-0.1
Weight	0.4	2.0	6.4	1.3	0.7	1.2	0.3	-2.5
Impedance of arm (right)	0.0	0.1	0.4	0.2	-0.6	-0.3	0.1	0.4
Arm fat percentage (right)	0.7	2.9	9.1	2.1	-0.4	0.7	0.6	-3.0
Trunk fat-free mass	0.1	0.5	1.0	0.0	0.9	0.6	-0.5	-1.0
Hip circumference	0.3	1.3	4.2	1.0	1.0	0.7	-0.1	-2.1
Time employed in main current job	0.1	0.1	0.2	-0.1	0.4	0.1	0.1	0.3
Alcohol intake versus 10 years previously	0.0	0.0	0.1	-0.1	0.3	-0.0	-0.1	0.3
Father’s age at death	0.8	1.0	2.2	-0.9	1.5	-0.4	-1.3	0.3
Worrier / anxious feelings	0.3	0.6	2.0	0.5	-0.8	-0.1	0.2	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.0	-0.1	-0.9	1.7	0.3	-2.0
Falls in the last year	0.8	1.1	1.8	0.7	-1.1	1.3	1.3	0.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.2	-1.1	1.0	-0.6	-0.4	-1.0
Number of live births	0.2	0.3	1.3	-0.2	1.1	0.3	0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.7	0.3	0.2	0.9	0.5	0.5
Pulse rate	0.9	1.4	5.8	-0.3	2.4	0.4	-0.1	-1.1
Happiness	2.5	3.0	8.7	0.5	-3.0	1.5	0.3	-1.9
Noisy workplace	1.1	1.3	2.7	1.6	-0.2	0.2	1.6	-1.1
Qualifications: A levels/AS levels or equivalent	0.8	1.8	5.3	0.9	2.3	1.2	-0.7	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.7	-1.3	-0.0	0.5	-0.5	1.2
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	-0.5	1.1	-1.1	-0.7	0.4
Asthma	0.1	0.2	0.3	0.5	-0.2	-0.6	-0.4	-0.4
Medication: Ibuprofen (e.g. Nurofen)	4.6	5.8	11.6	2.9	-0.8	3.4	2.7	-1.2
Medication: Cholesterol lowering	0.9	1.3	4.0	1.1	-0.5	0.6	0.9	-2.0
Depression (self-reported)	0.8	1.0	1.7	-1.1	-0.0	-1.3	-1.2	-0.7
Medication: Lansoprazole	1.1	1.3	2.8	0.4	-1.7	1.0	1.4	0.9
Prospective memory result	0.5	0.6	1.4	-0.2	-1.2	-0.3	1.0	-0.6
Lung cancer (father)	1.4	1.6	3.9	1.3	-0.9	2.0	1.3	-0.1
Illnesses of mother	0.4	0.5	1.7	0.5	-1.3	-0.7	-0.3	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.1	0.1	-0.0	1.0	0.2	0.8
Pulse wave Arterial Stiffness index	0.6	0.7	2.4	0.1	1.5	-1.1	0.0	-0.2
Impedance of arm (left)	0.1	0.3	0.7	-0.6	0.4	-0.8	-0.6	0.1
Arm fat mass (right)	0.6	2.7	9.0	1.9	-0.0	0.8	0.5	-3.0
Trunk predicted mass	0.1	0.5	1.1	0.1	1.0	0.6	-0.5	-1.0
Standing height	0.2	1.7	2.9	-1.7	1.7	0.1	-1.5	0.5
Length of working week for main job	1.7	1.9	3.9	2.0	0.6	1.4	1.6	0.9
Exposure to tobacco smoke at home	0.2	0.2	0.7	-0.8	0.1	-0.3	0.3	0.2
Breastfed as a baby	2.6	3.3	10.3	0.4	-1.5	-1.0	1.5	3.2
Tense / ‘highly strung’	1.2	2.0	4.5	-0.4	2.1	-1.8	-1.5	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	5.8	-2.3	0.3	-1.6	-2.4	-0.5
Hair/balding pattern: Pattern 4	0.4	1.1	2.0	-1.4	0.8	-1.0	-1.0	0.9
Birth weight of first child	0.1	0.2	0.6	-0.5	0.7	0.4	-0.4	-0.2
Peak expiratory flow (PEF)	0.1	0.3	1.0	-0.1	-0.3	1.0	0.7	-0.0
Pulse wave reflection index	0.5	0.7	2.1	1.0	-0.1	-1.4	0.3	0.5
Ever highly irritable/argumentative for 2 days	0.5	0.5	2.6	0.2	-1.6	0.0	0.2	0.3
Loud music exposure frequency	0.7	0.8	1.7	1.3	-1.3	-0.6	0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	6.8	-1.3	2.6	-0.2	-2.5	-0.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.3	-0.8	-0.2	0.2	-1.1	2.1
Blood clot in the leg (DVT)	0.7	0.9	2.4	0.8	-1.6	-1.0	0.5	-0.6
Medication: Paracetamol	1.6	2.7	6.3	1.1	-0.7	2.5	2.2	-0.9
Headache pain in last month	0.2	0.3	0.8	0.9	-0.5	0.2	0.7	-0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.5	-0.3	1.0	-0.5	-0.9	1.2
Glaucoma (self-reported)	0.5	0.6	1.2	-0.6	0.6	-0.0	-1.1	-0.9
Gout (self-reported)	0.3	0.4	1.6	0.4	0.2	0.1	-0.3	-1.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	1.7	-0.7	0.5	-1.3	-1.2	1.1
Medication: Amlodipine	0.9	1.2	3.9	-0.5	0.5	-2.0	-0.2	1.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.1	-0.1	0.1	-0.4	0.4
Birth weight	0.4	0.8	1.3	0.9	-0.9	1.1	1.1	0.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.6	-0.6	-0.3	0.8	-0.4
High blood pressure (siblings)	1.3	1.8	5.4	1.4	-0.6	1.2	2.3	0.0
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	0.2	0.3	0.4	-0.2	0.5
Body fat percentage	0.7	2.9	9.8	1.9	0.4	0.7	0.6	-3.1
Leg fat percentage (right)	0.7	2.6	8.1	1.9	0.4	0.6	0.7	-2.9
Arm fat-free mass (right)	0.2	0.8	2.5	-0.1	1.6	0.4	-0.6	-1.1
Exposure to tobacco smoke outside home	0.4	0.6	1.2	0.5	1.0	-0.7	0.2	-1.1
Comparative body size at age 10	0.4	1.0	2.8	0.1	-1.2	1.7	0.6	-0.7
Number of full brothers	0.9	1.2	3.6	-0.5	0.9	-1.1	-0.1	1.9
Worry too long after embarrassment	0.9	1.5	4.9	0.4	1.0	2.2	0.8	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.6	-1.6	0.0	-0.5	-1.3	-0.9
Wheeze or whistling in the chest in last year	2.5	4.5	9.6	3.1	0.5	1.4	1.0	-3.1
Number of children fathered	2.3	2.6	6.0	-1.0	2.1	-0.1	-2.4	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.7	1.9	6.1	-0.6	-2.5	0.3	0.5	1.7
Age at first live birth	1.1	1.9	3.5	1.7	-1.0	0.6	1.9	1.3
Pulse wave peak to peak time	0.6	0.7	1.9	-0.2	-1.4	1.2	-0.1	0.4
Health satisfaction	2.0	2.6	6.0	1.1	-2.4	1.4	1.0	-1.7
Shortness of breath walking on level ground	0.6	0.7	1.6	0.0	-1.1	1.3	0.3	-0.8
Qualifications: College or University degree	0.1	0.5	1.4	1.2	0.9	-0.0	0.1	-0.3
Eye problems/disorders: None of the above	1.5	1.8	4.4	0.8	-0.7	1.2	2.1	1.4
Mouth/teeth dental problems: Loose teeth	1.7	2.1	5.2	-0.1	2.3	-0.9	-1.3	-1.7
Emphysema/chronic bronchitis	0.2	0.2	0.3	-0.4	0.6	0.2	0.3	-0.5
Medication for pain relief, constipation, heartburn	2.2	3.7	7.6	-2.0	-0.4	-2.8	-1.5	2.2
Neck or shoulder pain in last month	0.5	0.8	1.7	-1.2	0.1	-0.8	-1.3	0.1
Medication: Blood pressure	0.1	0.2	0.8	0.2	0.3	0.5	0.2	-0.9
Angina (self-reported)	2.1	2.8	6.7	-1.1	2.6	0.2	-2.4	-0.4
Migraine (self-reported)	0.6	0.7	2.5	-0.1	0.4	0.1	-0.9	-1.6
Medication: Ibuprofen	3.7	4.4	7.4	2.5	-1.0	2.7	2.5	-1.1
Medication: Allopurinol	0.3	0.4	0.9	-0.3	0.7	-0.3	-0.7	-0.9
Medication: Omeprazole	0.2	0.3	0.9	0.5	0.2	0.3	-0.5	-0.9
Medication: Seretide 50 evohaler	0.8	0.9	2.2	0.5	-0.1	1.4	0.4	-1.5
Mean time to correctly identify matches	0.3	0.6	1.1	0.8	-0.3	1.1	1.0	-0.1
Heart disease (mother)	2.0	2.4	7.7	0.0	2.8	-0.9	-0.7	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.7	1.3	-0.5	1.6	0.8	-1.3
Whole body fat mass	0.6	2.6	8.8	1.7	0.5	0.9	0.5	-3.0
Leg fat mass (right)	0.8	2.9	9.2	1.8	0.5	1.1	0.7	-3.0
Arm predicted mass (right)	0.2	0.8	2.4	-0.4	1.5	0.2	-0.8	-1.0
Pulse rate, automated reading	0.3	0.9	2.1	-0.1	1.0	1.1	0.4	-1.5
Alcohol intake frequency.	0.5	1.3	3.4	-0.8	-0.8	-1.2	-0.4	1.9
Comparative height size at age 10	0.1	0.6	1.9	0.4	1.4	0.4	0.4	0.7
Number of full sisters	0.6	0.7	1.4	0.3	-1.2	0.8	1.1	-0.5
Suffer from ‘nerves’	0.8	1.3	3.8	-0.5	-0.2	-2.0	-1.2	0.9
Overall health rating	0.8	1.8	4.6	1.0	-0.2	1.7	0.8	-2.1
Chest pain or discomfort	0.4	0.6	1.8	0.4	1.4	0.2	-0.8	0.1
Had major operations	0.9	1.1	2.1	1.2	1.1	0.5	-0.7	-1.4
Age at last live birth	2.3	3.3	6.9	2.4	-0.8	1.8	2.6	0.5
Family relationship satisfaction	0.6	0.7	3.5	-0.1	-1.9	-0.2	-0.2	-0.0
Leg pain on walking	0.3	0.4	1.0	-0.2	-0.5	-0.9	0.2	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	0.1	-0.9	0.8	0.5	-1.2
Commuting to job workplace: Car/motor vehicle	1.9	2.2	5.8	0.8	0.9	1.6	1.1	-2.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.9	-0.2	0.3	-0.2	-0.2	-0.9
Medication: Aspirin	0.4	0.5	1.1	0.7	1.0	0.5	0.1	-1.0
Supplements: Vitamin C	0.3	0.4	1.3	1.1	-0.5	0.3	0.3	-0.4
Knee pain experienced in last month	1.6	2.5	7.6	2.8	0.4	1.4	1.6	-0.7
Hypertension (Self-reported)	0.5	1.5	2.8	1.7	-0.5	0.1	1.7	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.3	0.4	-1.0	1.2	0.4	-0.2
Illnesses of father: Heart disease	0.6	0.9	2.4	-0.3	0.3	1.5	0.4	-1.3
Illnesses of siblings: Diabetes	0.9	1.1	4.4	-0.0	0.9	0.7	-0.3	-2.1
Smoking status: Previous	0.4	0.6	2.1	0.5	-1.4	0.7	0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.7	-0.3	-0.6	1.3	-0.1	0.4
Whole body fat-free mass	0.1	0.7	1.6	0.1	1.1	0.6	-0.6	-1.3
Leg fat-free mass (right)	0.1	0.8	2.1	0.3	0.9	0.6	-0.6	-1.4
Arm fat percentage (left)	0.8	3.0	11.2	1.8	0.1	0.6	0.3	-3.4
Average weekly red wine intake	0.2	0.3	0.5	-0.5	0.6	0.7	0.1	-0.7
Handedness (chirality/laterality): Left-handed	5.9	7.1	12.3	-3.3	2.8	-1.9	-3.5	1.0
Mood swings	0.4	0.7	1.9	1.0	0.2	1.4	0.3	0.5
Loneliness, isolation	0.2	0.3	0.7	-0.4	-0.6	-0.3	-0.5	0.9
Long-standing illness, disability or infirmity	0.3	0.5	1.1	-0.5	0.0	0.7	-1.1	-0.7
Ever had bowel cancer screening	0.4	0.4	1.6	0.4	1.3	-0.2	-0.7	-0.2
Diabetes diagnosed by doctor	0.5	0.8	1.3	-1.0	-0.7	-0.7	-0.8	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.8	-0.5	-0.1	0.5	0.9	1.3
Friendships satisfaction	1.8	2.3	9.6	-0.8	-3.1	0.3	0.8	-0.5
Qualifications: nursing, teaching	1.3	2.1	7.7	-0.0	2.8	0.7	-1.1	-1.0
Commuting to job workplace: Walk	0.1	0.1	0.3	0.3	-0.3	-0.5	0.1	0.2
Eye problems/disorders: Cataract	0.7	0.9	2.2	-0.4	1.5	-0.2	-1.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.3	0.2	0.7	0.3	-0.8	-1.5
Medication for cholesterol	0.6	0.9	3.9	-0.2	-0.2	2.0	0.7	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	1.0	0.8	0.5	0.3	-0.1
Back pain experienced in last month	0.1	0.1	0.2	-0.2	-0.3	0.1	-0.5	0.2
Mineral and other dietary supplements	1.8	2.4	6.4	-2.1	0.0	-0.5	-0.7	2.5
Breast cancer (self-reported)	2.2	2.6	7.6	1.4	-0.7	2.8	1.7	0.2
Asthma (self-reported)	0.1	0.2	0.6	0.4	0.0	-0.8	-0.5	-0.1
Osteoporosis (self-reported)	0.8	1.0	3.0	0.7	0.7	0.9	0.5	-1.7
Osteoarthritis (self-reported)	0.7	1.0	3.2	0.2	1.0	-0.4	-0.7	-1.8
Medication: Aspirin	0.4	0.6	1.2	1.1	0.7	0.5	0.3	-0.9
Medication: Gliclazide	0.7	0.8	1.8	1.4	-1.3	-0.1	0.6	-0.4
Illnesses of father: None of the above (group 1)	0.6	0.7	2.0	-0.5	-0.5	-1.4	-0.7	0.8
Smoking status: Current	3.7	5.8	9.8	3.1	1.4	1.9	2.3	-2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.7	0.2	-0.9	1.2	0.8	-1.3
Whole body water mass	0.1	0.6	1.5	0.1	1.0	0.6	-0.6	-1.2
Leg predicted mass (right)	0.1	0.8	2.3	0.4	0.8	0.6	-0.6	-1.5
Arm fat mass (left)	0.6	2.4	8.6	1.7	0.3	0.7	0.3	-2.9
Number of self-reported non-cancer illnesses	1.0	1.8	7.6	1.0	-0.5	-0.2	0.0	-2.8
Average weekly champagne plus white wine intake	0.4	0.5	0.9	0.7	0.5	-1.0	-0.8	-0.5
Miserableness	1.2	2.0	7.0	1.1	0.4	2.6	0.4	-1.2
Guilty feelings	0.6	0.9	2.6	-0.4	1.6	-0.8	-1.0	0.6
Wears glasses or contact lenses	0.7	0.8	2.0	0.5	0.8	-0.9	-0.1	-1.4
Ever taken oral contraceptive pill	1.2	1.4	3.7	0.8	-0.6	1.4	0.4	-1.9
Hearing aid user	0.3	0.3	0.9	-0.2	-1.0	-0.5	-0.7	0.0
Mother’s age at death	2.3	2.9	6.1	-2.5	-0.1	-0.9	-2.0	1.9
Financial situation satisfaction	0.8	1.0	2.1	0.5	-0.3	1.5	-1.2	-1.0
Tinnitus: Yes, now most or all of the time	1.6	1.9	4.5	-2.1	0.6	-1.7	-0.9	-0.9
Commuting to job workplace: Public transport	1.0	1.1	3.0	-1.0	-0.2	-1.1	-1.7	0.7
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	0.3	0.7	-0.7	-0.6	-1.0
Medication: Blood pressure	0.2	0.5	1.9	0.3	0.3	-1.4	-0.3	-0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.1	0.3	0.1	-0.4	-0.2
Supplements: Fish oil (including cod liver oil)	2.8	3.7	8.7	3.0	1.5	0.4	1.2	-2.4
High cholesterol (Self-reported)	0.9	1.7	2.5	1.6	-1.4	1.2	1.6	0.4
Medication: Bendroflumethiazide	0.9	1.4	4.1	-1.2	0.1	-0.9	-2.0	-0.9
Medication: Paracetamol	1.9	3.0	7.7	1.1	-0.2	2.8	2.3	-0.8
Medication: Lisinopril	2.1	2.7	6.9	-0.4	-2.6	1.1	2.0	-1.1
Medication: Atorvastatin	0.6	0.8	2.6	-0.2	-1.6	0.1	0.7	-0.8
Illnesses of father: High blood pressure	0.7	0.8	1.9	1.1	1.1	-0.0	1.4	-0.1
Alcohol drinker status: Never	0.6	0.8	2.5	0.4	-0.6	-0.7	0.5	1.6
Ever smoked	1.7	2.9	6.3	2.5	0.8	1.9	1.4	-1.3
Basal metabolic rate	0.2	1.0	2.9	0.5	1.0	0.8	-0.4	-1.7
Leg fat percentage (left)	0.8	2.8	8.6	2.0	0.1	0.8	0.9	-2.9
Arm fat-free mass (left)	0.1	0.5	1.1	0.4	1.0	0.6	-0.2	-1.0
Number of operations (self-reported)	0.2	0.3	0.6	0.8	0.6	-0.6	-0.1	-0.3
Average weekly beer plus cider intake	1.3	1.8	5.1	1.0	-2.3	1.1	1.2	-0.7
Irritability	0.8	1.4	3.3	0.8	-1.8	1.4	0.7	-0.8
Risk taking	1.2	1.7	4.6	-0.4	1.0	-1.2	-2.1	-1.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.3	-1.1	-0.8	0.6	-0.4	-0.5
Fractured/broken bones in last 5 years	0.8	1.1	1.7	-0.8	-1.1	-1.0	-1.3	-0.9
Age started oral contraceptive pill	1.4	1.7	4.5	-0.6	2.1	-1.3	-1.2	0.9
Diastolic blood pressure, automated reading	0.6	1.8	4.4	2.1	0.6	1.1	1.6	-0.8
Ever depressed for a whole week	0.4	0.5	1.9	-0.1	-1.4	-0.5	0.1	0.5
Unable to work because of sickness or disability	2.1	2.7	6.5	1.4	-1.1	2.5	1.0	-1.8
Commuting to job workplace: Cycle	0.6	0.8	2.9	1.7	-0.1	-0.2	1.0	0.0
Myopia	5.3	7.6	16.1	-1.6	2.4	-3.7	-4.0	-0.3
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.2	-1.8	0.3	-0.5	-1.5	1.6
Cholesterol lowering medication	0.1	0.2	0.5	0.7	0.4	0.5	0.1	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.4	1.3	-0.3	1.4	0.5	-1.8
Pain experienced in last month	0.5	0.8	2.2	0.2	-1.1	0.5	1.5	0.1
Supplements: Calcium	0.5	0.6	2.2	1.5	-0.7	-0.0	0.4	0.3
Basal cell carcinoma (self-reported)	1.0	1.2	3.5	-1.0	-0.8	-1.9	-0.9	0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.8	1.1	1.7	0.3	-0.1	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.1	0.8	-1.4	-1.1	0.7	-0.0
Heart disease (siblings)	0.4	0.5	1.0	0.5	1.0	0.3	0.9	-0.5
Alcohol drinker status: Previous	3.0	3.4	7.1	-2.0	2.3	-0.7	-2.7	-0.7
Pack years of smoking	2.6	3.8	7.3	2.1	1.2	2.7	1.7	-1.7
Impedance of whole body	0.1	0.3	0.9	-0.6	0.1	-1.0	-0.1	0.5
Leg fat mass (left)	0.8	2.9	9.2	1.8	0.5	1.2	0.7	-3.0
Arm predicted mass (left)	0.1	0.6	1.4	0.3	1.2	0.6	-0.3	-0.9