Hub : Genes

NPIPB4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.125	0.0518	4.0e-03	0.029	NA	0.009	NA	0.015	2.3e-03	NA	6.2e-02	NA	2.2e-02
2	GTEx	Cells EBV-transformed lymphocytes	0.399	0.0990	3.6e-04	0.085	NA	0.152	NA	0.141	1.0e-03	NA	1.2e-05	NA	2.4e-05
3	GTEx	Cells Transformed fibroblasts	0.065	0.0390	9.5e-03	-0.001	NA	0.007	NA	0.004	4.4e-01	NA	9.3e-02	NA	1.5e-01
4	GTEx	Esophagus Mucosa	0.119	0.0590	7.4e-03	-0.004	NA	-0.001	NA	-0.002	8.1e-01	NA	3.6e-01	NA	5.0e-01
5	GTEx	Muscle Skeletal	0.142	0.0416	1.5e-06	0.010	NA	0.012	NA	0.024	3.2e-02	NA	2.0e-02	NA	1.7e-03
6	GTEx	Thyroid	0.087	0.0430	7.1e-03	0.008	NA	0.025	NA	0.004	7.1e-02	NA	4.6e-03	NA	1.6e-01
7	METSIM	Adipose	0.121	0.0373	1.3e-11	0.058	0.083	0.089	0.078	0.061	4.1e-09	2.1e-12	2.9e-13	8.3e-12	1.8e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	1.5	0.6	0.1	0.1	-0.8	-0.1	-1.2	-1.2
Bipolar Disorder or Schizophrenia	1.7	4.2	10.3	2.9	-0.9	0.1	-2.2	0.8	-2.0	-3.2
Depressed Affect (Nagel 2018)	0.4	0.8	2.4	-0.1	0.3	-1.0	-0.1	-1.6	-1.1	-0.9
Depression (Nagel 2018)	1.2	1.9	5.8	-0.3	-0.9	-0.7	-2.4	0.5	-2.3	-0.5
Intelligence (Savage-Jansen 2018)	0.9	2.8	8.6	-0.3	-1.2	-2.9	-1.6	-1.9	-1.7	-0.1
Neuroticism (Nagel 2018)	0.2	0.4	1.1	0.2	-0.4	-0.7	-1.1	-0.4	-0.6	-0.6
Schizophrenia (2018)	2.2	4.6	12.1	3.2	-0.7	-0.0	-2.2	1.3	-1.6	-3.5
Schizophrenia vs Biploar Disorder	1.1	1.5	4.2	1.7	0.7	0.9	0.3	2.1	1.4	-0.2
Worry (Nagel 2018)	0.8	1.6	4.3	0.8	-1.3	-0.8	-2.1	0.1	-1.1	-1.7
Alzheimer’s Disease (in mother)	1.2	1.4	5.2	1.5	-0.8	0.9	-0.8	2.3	0.6	0.2
Alzheimer’s Disease (in father)	0.4	0.4	1.8	-0.2	-0.1	-1.3	-0.2	-0.5	-0.6	-0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	2.7	1.6	-0.6	-0.1	-0.7	1.2	0.3	-0.3
Crohns Disease (2017)	0.8	1.7	3.4	-1.6	0.5	-1.3	-0.0	-1.7	-0.9	-1.9
Irritable Bowel Disease (IBD)	0.3	0.7	1.9	-0.9	1.4	-0.5	0.8	-1.1	-0.1	-0.6
Ulcerative Colitis (UC)	0.5	1.0	2.7	0.1	1.3	0.4	1.6	-0.1	0.9	1.3
Major Depression (MDD)	3.6	4.4	9.1	-0.6	-0.5	-1.6	-2.1	-2.2	-3.0	-3.0
Reaction Time	0.8	1.5	3.4	-0.6	-1.7	-1.5	-0.1	-1.2	-1.8	0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.7	-0.8	-0.5	-1.3	-0.7	-1.0	-0.6	1.0
Breast Cancer	0.2	0.4	1.7	0.3	-1.3	-0.3	-0.0	-0.4	-0.3	0.9
Ovarian Cancer	2.2	3.0	8.1	-1.1	-0.7	-2.8	-1.2	-1.5	-2.1	-1.6
Prostate Cancer	0.8	1.1	3.7	0.9	1.1	0.8	1.9	0.8	1.0	0.1
Age at First Birth	1.0	1.4	5.6	2.4	0.0	0.3	0.3	0.8	1.1	-1.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.7	0.3	-0.3	1.6	-0.1	1.4	0.6	0.4
Coronary Artery Disease (CAD)	2.7	3.2	10.4	1.2	0.6	2.3	0.6	3.2	1.5	1.5
Crohns Disease (2012)	0.6	0.9	4.2	-0.8	0.3	-0.1	-0.7	-0.5	-0.9	-2.0
Mean Putamen Volume	1.7	1.9	7.1	1.7	0.8	1.4	0.1	2.7	1.0	-0.2
Fasting Glucose	2.3	2.7	5.8	0.5	-1.4	-1.9	-1.4	-0.7	-2.3	-2.4
HbA1C	1.0	1.1	2.9	0.5	-0.8	-0.3	-1.2	-0.3	-1.6	-1.7
HDL Cholesterol	0.3	0.5	1.5	1.2	0.3	0.5	1.1	0.2	0.7	0.1
LDL Cholesterol	0.8	1.3	3.6	-0.3	-1.9	-0.4	-1.4	-1.1	-1.3	0.9
Lupus	1.4	2.1	3.9	-1.2	-1.8	-1.3	-2.0	-1.6	-1.5	-0.1
Neuroticism (2016)	0.7	0.9	2.7	-0.8	1.6	0.4	1.5	-0.5	0.5	0.5
Primary Biliary Cirrhosis	0.2	0.3	0.7	-0.8	0.6	-0.1	-0.0	-0.8	-0.3	0.1
Rheumatoid Arthritis	0.5	0.6	2.0	1.4	-0.7	0.3	0.3	0.9	1.0	-0.1
Schizophrenia (2014)	2.1	4.7	15.9	3.1	-0.1	0.2	-2.0	1.2	-1.3	-4.0
Triglycerides	1.1	1.8	3.0	-1.5	-0.5	-1.6	-1.2	-1.7	-1.7	-0.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	0.9	0.5	0.9	0.8	1.3	0.1	-0.2
Ulcerative Colitis	0.8	1.2	3.3	0.6	1.8	1.0	1.2	1.0	0.9	-0.0
Blood Eosinophil Count	0.1	0.7	3.2	0.1	-1.0	-0.3	-1.8	-0.4	-0.8	-0.0
Blood Platelet Count	0.2	1.9	3.8	0.5	1.4	1.7	1.9	0.3	2.0	0.9
Blood Red Count	0.2	1.6	6.3	0.9	0.5	0.8	1.5	-0.0	1.0	2.5
Blood White Count	0.1	0.6	2.0	0.7	-1.4	-0.9	-0.6	-0.2	-0.8	0.4
Heel T-Score	2.8	22.2	43.7	6.6	3.0	4.2	4.0	6.5	5.0	-0.6
BMI	0.2	1.4	3.1	1.6	-1.8	1.0	-0.5	1.1	0.8	1.0
Height	0.1	2.3	10.1	-0.6	1.7	-0.3	1.4	-3.2	0.6	-0.8
Waist Hip Ratio (WHR)	0.1	0.6	1.6	0.4	-0.5	-0.5	-0.5	1.0	-0.8	1.3
Systolic Blood Pressure	0.4	1.8	4.8	1.2	0.0	-0.6	2.0	1.0	0.9	2.2
Smoking Status	0.2	0.6	2.1	-1.2	-0.1	-0.0	-0.0	0.4	-0.4	1.5
Allergy or Eczema	0.6	1.5	3.7	-1.0	-1.3	-1.4	-1.1	-0.8	-1.9	-0.5
Cardiovascular Disease	0.2	0.5	1.9	0.3	0.4	-0.8	0.9	0.0	-1.4	-0.4
Hypothyroidism (self reported)	0.7	1.7	4.6	2.1	-1.6	1.3	-0.1	1.6	0.1	0.6
Respiratory disease	0.6	1.3	5.2	1.1	0.3	1.1	0.6	2.3	0.8	-0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	0.8	-0.5	-0.4	0.2	-0.0	-0.4	-0.4
Lung FEV1/FVC ratio	0.2	1.2	3.2	1.7	-1.8	-0.2	-1.2	0.3	-0.7	-0.5
Lung FVC	0.1	0.6	1.9	-0.2	-0.6	-1.4	0.1	-0.5	-1.2	0.1
Neuroticism	1.0	2.3	3.2	-1.0	-1.4	-1.5	-1.8	-1.8	-1.7	-1.4
Chronotype (morning person)	1.0	2.3	6.6	-2.5	0.6	-0.7	-0.4	-2.6	-0.2	1.5
Hair Pigment	0.0	1.3	3.7	0.7	1.9	0.9	1.2	1.1	0.4	-1.2
Tanning	0.1	1.1	4.0	-0.1	0.1	0.8	0.1	-0.8	2.0	1.5
Hand grip strength (left)	0.2	0.6	1.5	0.2	0.0	-1.1	0.7	-1.2	-0.5	-0.9
Number of treatments/medications taken	0.6	1.1	3.1	0.6	0.4	1.6	0.3	1.8	1.0	-0.3
Average weekly spirits intake	0.6	0.8	1.7	-1.3	-0.7	0.8	-0.9	-0.0	-0.4	1.3
Sensitivity / hurt feelings	0.6	1.0	2.4	-1.6	0.3	-0.6	-1.1	-1.3	-0.9	-0.6
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.8	0.2	0.0	-0.8	-0.9	0.0	-0.2	0.5
Hearing difficulty/problems: Yes	0.8	1.3	5.1	-0.5	-0.3	2.3	-1.2	1.1	0.6	-0.4
Relative age of first facial hair	0.3	0.6	2.3	-0.3	-0.4	-0.7	0.3	-0.7	-1.5	-0.7
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.0	-0.6	0.7	-0.3	-1.7	-0.7	-1.1	-1.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	-1.1	-0.3	0.2	-0.8	0.2	-1.1	0.4
Ever had hysterectomy (womb removed)	3.3	3.7	8.4	-0.1	2.0	2.1	2.7	0.5	2.9	1.3
Systolic blood pressure, automated reading	1.9	5.5	12.9	1.5	1.1	1.5	3.6	1.5	3.2	2.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.5	1.2	-0.8	0.3	0.2	-0.2	0.6	-0.9
Angina	2.3	3.1	7.5	-0.9	-1.8	-1.4	-2.7	-0.1	-2.4	-1.6
Medication for hormone replacement therapy	2.2	2.5	3.8	-1.4	-1.8	-1.2	-2.0	-1.5	-2.0	-1.2
Vitamin and mineral supplements	0.3	0.5	0.9	0.8	1.0	-0.7	0.4	-0.1	0.9	-0.6
Supplements: Zinc	0.3	0.4	0.6	-0.7	0.5	0.8	-0.3	0.8	-0.6	0.4
Medication: Co-codamol	0.8	1.0	3.5	0.1	0.4	0.9	0.8	0.3	1.2	1.9
Medication: Metformin	0.3	0.4	1.2	1.1	-0.0	0.3	0.7	0.4	0.8	-0.1
Diabetes (father)	0.2	0.2	1.0	-0.2	-0.1	0.3	-0.7	-0.1	0.1	-1.0
Diabetes (mother)	0.6	0.7	1.7	0.3	-0.0	-1.3	-0.7	0.2	-1.2	-1.2
Severe depression (siblings)	0.8	0.9	2.3	-0.4	-0.9	-1.1	-1.2	-0.6	-1.5	0.2
Pack years adult smoking proportion	0.4	0.7	2.4	0.4	1.6	-0.0	1.1	0.7	0.1	-0.6
Impedance of leg (right)	0.4	2.0	7.3	-0.3	2.7	1.3	1.2	0.8	1.7	-0.5
Leg fat-free mass (left)	0.3	1.6	6.6	0.8	-2.6	-0.8	-0.9	-1.4	-0.8	-0.4
Trunk fat percentage	0.5	2.2	5.2	1.6	-0.1	2.3	0.8	1.3	2.2	0.5
Hand grip strength (right)	0.6	1.6	5.9	-0.8	-0.1	-1.6	-0.3	-2.4	-1.0	-1.0
Townsend deprivation index at recruitment	2.6	3.6	10.8	-1.2	-1.6	-2.3	-2.0	-1.2	-3.3	-0.2
Current tobacco smoking	0.2	0.4	0.9	-0.6	0.9	0.1	0.2	-0.8	0.0	0.9
Average weekly fortified wine intake	0.3	0.4	1.0	-0.0	-0.1	-0.2	-0.7	0.2	-1.0	-0.9
Maternal smoking around birth	0.3	0.4	1.1	1.1	0.8	-0.3	0.4	0.6	0.2	-0.3
Fed-up feelings	0.4	0.7	2.8	-0.6	0.5	-1.0	0.3	-1.7	0.1	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	6.0	-0.3	-2.0	-1.5	-2.5	-0.4	-2.1	0.4
Relative age voice broke	0.8	1.3	3.4	-0.4	-0.8	-1.4	-0.5	-1.4	-1.8	-0.7
Taking other prescription medications	0.6	0.9	2.5	-0.5	0.2	1.6	0.3	1.3	1.2	0.1
Age when periods started (menarche)	0.9	2.1	4.6	-0.5	-0.8	-2.1	-1.1	-1.6	-2.0	-1.1
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.7	-1.9	0.8	-1.4	0.3	-1.4	-0.9	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	16.5	4.1	0.6	0.9	1.5	2.7	2.1	-0.6
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.5	-0.0	-0.7	-1.0	-2.1	-0.0	-1.4	-2.1
Qualifications: CSEs or equivalent	0.2	0.2	0.7	0.3	0.2	-0.4	0.0	0.4	-0.6	-0.8
Serious illness, injury or assault to yourself	1.1	1.3	4.3	-0.4	-1.0	-0.2	-1.7	0.7	-2.1	-0.6
High blood pressure	0.5	1.5	4.7	0.5	2.2	0.0	2.1	0.6	0.7	-0.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.4	-0.6	-1.0	-0.8	-0.8	0.1	-1.6	-0.6
Multivitamins +/- minerals	0.6	0.8	1.4	-1.0	-1.2	-0.3	-0.6	-0.8	-1.1	0.8
Stomach or abdominal pain in last month	0.5	0.6	1.6	0.6	-0.6	-0.8	-0.9	-0.0	-0.9	-1.3
Supplements: Glucosamine	0.4	0.5	1.8	-0.6	0.1	0.9	0.6	-0.3	1.3	0.5
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	5.0	-0.6	-1.5	-0.2	-2.2	1.1	-1.2	0.8
Medication: Atenolol	0.9	1.1	3.1	0.0	-1.8	-1.2	-1.0	-1.1	-0.9	0.3
Medication: Levothyroxine sodium	0.6	1.0	2.7	0.9	-1.6	-0.1	-1.1	-0.2	-1.4	-0.6
Sitting height	0.5	3.4	12.2	-1.9	-1.4	-1.8	-0.8	-3.5	-1.5	0.4
Chronic bronchitis/emphysema (father)	0.5	0.6	3.2	0.6	0.4	-0.2	-0.5	1.8	-0.1	-0.6
High blood pressure (mother)	0.7	1.0	3.2	-1.4	0.7	-0.9	0.6	-1.8	0.3	0.3
Body mass index (BMI)	0.4	1.8	4.5	2.1	-1.7	1.1	0.2	1.4	1.1	0.9
Impedance of leg (left)	0.6	2.7	10.3	-0.9	3.2	1.3	1.5	0.3	1.9	0.2
Leg predicted mass (left)	0.3	1.7	6.5	0.8	-2.5	-0.8	-1.0	-1.4	-0.9	-0.5
Trunk fat mass	0.3	1.4	3.3	1.6	-0.5	1.6	0.7	0.6	1.8	0.3
Waist circumference	0.2	0.8	2.4	1.4	-1.6	0.3	-0.4	0.7	0.4	0.4
Number of incorrect matches in round	0.6	1.0	2.9	-0.8	1.7	-0.1	1.1	-0.6	0.4	-1.4
Past tobacco smoking	0.1	0.2	0.6	-0.2	-0.3	0.4	-0.8	-0.6	0.6	-0.2
Alcohol usually taken with meals	0.6	1.0	2.9	0.9	1.4	0.6	0.4	0.8	0.0	-1.7
Nervous feelings	0.1	0.3	0.7	0.5	-0.0	-0.6	-0.7	0.1	0.1	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.5	0.5	-0.8	0.3	-1.6	0.8	-0.2	-0.3
Hearing difficulty/problems with background noise	0.5	0.8	1.6	-1.1	-0.6	0.7	-1.2	0.3	-1.3	-0.5
Hair/balding pattern: Pattern 2	0.6	0.7	2.1	-1.4	-0.5	-0.9	-0.3	-1.2	-0.2	0.7
Had menopause	2.0	2.5	6.7	-0.1	2.6	2.4	0.9	1.1	1.6	0.2
Had other major operations	0.4	0.4	2.0	-0.4	0.2	1.4	0.4	0.7	0.1	0.6
Forced vital capacity (FVC)	0.4	1.7	4.7	-0.2	-0.8	-2.0	-0.4	-1.1	-2.2	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	14.1	3.8	0.6	0.6	1.4	2.3	1.9	-0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	2.1	-0.8	0.5	-0.2	0.1	-1.5	0.2	0.2
Qualifications: None of the above	0.4	0.8	2.0	-0.6	-0.2	-1.2	-0.4	-1.4	-1.2	0.1
Financial difficulties in last 2 years	0.2	0.3	1.0	-0.5	0.4	-0.3	-0.4	-1.0	0.7	0.3
Mouth/teeth dental problems	1.0	1.6	6.0	0.4	0.8	2.4	0.2	0.1	2.0	-0.5
Heart attack	0.9	1.1	4.6	-0.3	-0.7	-0.2	-2.1	0.2	-1.5	0.4
Allergy	0.3	0.7	1.9	0.3	0.1	-0.3	0.6	-1.1	1.0	1.4
Pain all over the body in last month	0.2	0.2	0.6	0.3	-0.1	-0.7	-0.1	-0.6	-0.5	-0.2
Diabetes (self-reported)	0.1	0.2	0.5	0.7	-0.3	0.3	-0.3	0.7	0.1	-0.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.2	-0.2	0.7	1.1	0.4	1.8	0.4	0.7
Medication: Ramipril	0.5	0.6	2.3	-0.5	1.5	0.9	0.1	0.6	0.2	0.4
Medication: Simvastatin	1.3	1.9	5.5	-1.3	-1.2	-1.6	-1.1	-0.8	-2.3	0.0
Fluid intelligence score	0.1	0.3	0.7	-0.5	0.4	0.1	-0.3	0.9	-0.6	0.5
Illnesses of siblings	0.8	1.2	4.1	-0.9	0.2	-0.2	-1.2	-0.9	-0.8	-2.0
Neuroticism score	0.5	1.0	3.4	-0.8	-0.9	-0.7	-1.8	-0.7	-0.9	-0.8
Weight	0.1	0.7	1.9	1.4	-1.4	0.4	0.3	-0.2	0.8	0.1
Impedance of arm (right)	0.2	1.2	3.0	0.0	1.7	1.2	0.2	1.2	0.5	-1.4
Arm fat percentage (right)	0.7	3.0	6.8	2.6	-1.2	2.0	0.6	2.1	1.8	0.5
Trunk fat-free mass	0.3	1.5	4.6	0.1	-1.8	-1.5	-0.4	-2.1	-0.5	0.0
Hip circumference	0.2	0.9	2.4	1.6	-1.2	0.9	-0.3	0.4	0.7	-1.0
Time employed in main current job	0.4	0.5	1.9	-0.1	0.6	0.5	0.6	0.7	0.3	1.4
Alcohol intake versus 10 years previously	1.0	1.5	3.5	-0.1	-0.5	-1.9	-0.5	-1.9	-1.4	-0.8
Father’s age at death	1.1	1.4	3.4	1.9	0.4	1.4	0.6	1.0	1.5	-0.9
Worrier / anxious feelings	0.3	0.5	1.2	0.0	-1.1	-0.8	-0.9	-0.2	-0.7	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	4.0	-0.2	-1.1	-0.7	-2.0	-0.4	-1.0	-1.0
Falls in the last year	0.6	0.8	2.6	-1.6	0.7	-0.2	-0.4	-0.4	-1.1	-0.9
Hair/balding pattern: Pattern 3	0.9	1.3	4.9	0.1	0.2	0.8	2.2	-0.0	1.6	1.1
Number of live births	1.6	2.2	4.5	-1.3	-1.0	-2.0	-2.1	-0.6	-2.0	-0.2
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	9.3	0.3	-2.0	-2.4	-1.9	-1.1	-3.0	-2.0
Pulse rate	0.5	0.9	3.7	-1.0	1.9	0.1	1.1	-0.3	0.3	0.3
Happiness	1.6	1.9	3.1	-1.8	-1.3	-1.4	-1.2	-1.7	-1.4	0.5
Noisy workplace	0.6	0.7	2.5	0.3	1.6	0.5	0.2	0.8	1.1	-0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	0.9	-1.1	0.0	-0.4	0.6	-0.7	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	4.0	-0.2	-1.3	-1.6	-1.4	-0.6	-2.0	-1.7
Mouth/teeth dental problems: Dentures	0.5	0.9	3.4	-0.5	-0.3	-1.8	0.9	-0.2	-1.1	0.6
Asthma	0.5	1.0	1.8	0.7	0.9	1.2	1.4	1.3	0.9	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.1	-0.8	-1.1	-1.4	-0.2	-1.5	-1.0	-0.8
Medication: Cholesterol lowering	0.3	0.5	1.3	0.6	-0.3	-0.3	-0.6	1.1	-1.0	-0.7
Depression (self-reported)	2.5	3.0	6.8	-0.9	-2.0	-2.6	-1.6	-1.1	-2.1	1.0
Medication: Lansoprazole	1.4	1.6	4.6	0.7	1.6	1.4	0.2	2.1	1.2	0.2
Prospective memory result	1.3	1.6	3.3	-0.9	-0.8	-1.8	-1.2	-1.2	-1.7	-0.6
Lung cancer (father)	0.2	0.2	0.6	-0.8	-0.3	-0.4	-0.3	-0.3	-0.4	-0.6
Illnesses of mother	1.5	1.8	5.8	-1.3	-1.1	-1.3	-0.6	-2.4	-1.4	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	7.6	0.9	-1.8	-2.3	-1.7	-0.8	-2.8	-2.7
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	-0.3	0.6	0.2	0.9	0.3	0.8	0.3
Impedance of arm (left)	0.3	1.3	6.0	-0.8	2.4	0.8	0.0	0.6	0.1	-1.3
Arm fat mass (right)	0.4	1.6	4.4	2.1	-1.6	1.2	0.2	1.0	1.2	0.5
Trunk predicted mass	0.3	1.5	4.7	0.1	-1.8	-1.5	-0.4	-2.2	-0.5	0.0
Standing height	0.3	2.7	11.7	-1.5	0.7	-1.4	0.0	-3.4	-0.5	-1.5
Length of working week for main job	0.3	0.3	0.7	0.3	-0.7	-0.3	-0.5	-0.1	-0.8	0.6
Exposure to tobacco smoke at home	0.7	0.8	2.9	1.7	-0.3	0.9	0.3	1.2	0.5	-0.3
Breastfed as a baby	0.9	1.1	2.3	-0.0	0.9	1.5	1.3	1.0	1.3	0.7
Tense / ‘highly strung’	0.4	0.7	1.4	0.9	-1.2	0.0	-1.1	0.2	0.1	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.7	-0.1	-0.7	-0.4	-1.6	-0.3	-1.5	-0.1
Hair/balding pattern: Pattern 4	0.6	1.4	4.1	0.9	1.3	-0.1	1.3	-1.0	2.0	-0.1
Birth weight of first child	0.5	0.8	2.9	0.5	0.1	0.0	1.7	-0.2	1.4	0.7
Peak expiratory flow (PEF)	1.0	2.3	3.5	1.2	-1.8	-1.5	-1.9	-0.4	-1.6	-1.7
Pulse wave reflection index	0.3	0.4	1.1	-0.6	-1.1	-0.3	-0.2	0.3	0.2	1.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.8	0.2	-0.6	-1.7	-1.2	-0.8	-0.9	-1.2
Loud music exposure frequency	0.8	0.9	1.9	-0.8	-0.6	-0.7	-1.2	-1.4	-1.1	-0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.2	-0.2	-1.5	-1.4	-0.6	-1.3	-1.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.2	0.8	-1.5	-1.1	-1.0	0.5	-0.6	0.7
Blood clot in the leg (DVT)	0.7	0.9	3.2	-1.1	0.9	-0.2	-0.8	-0.6	-0.5	-1.8
Medication: Paracetamol	0.8	1.4	3.1	1.8	0.3	1.7	0.9	1.5	0.6	-0.5
Headache pain in last month	0.4	0.6	1.5	-0.9	-0.2	1.2	-0.8	1.0	0.0	-0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.9	-1.1	0.6	0.8	0.4	-0.6	1.1	1.4
Glaucoma (self-reported)	0.7	0.9	1.8	1.0	-1.2	-0.4	-1.0	0.7	-1.3	-0.3
Gout (self-reported)	1.0	1.4	4.4	0.8	-2.1	-0.3	-1.4	0.8	-1.3	-0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.6	0.9	-1.9	0.5	-0.8	-0.0	-0.4	-0.1
Medication: Amlodipine	1.2	1.7	6.2	-1.3	0.9	-1.4	1.1	-2.5	-0.1	-0.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.0	-0.7	1.4	1.2	1.2	0.8	0.5	-0.3
Birth weight	0.6	1.3	3.7	1.1	1.2	1.0	-0.2	0.7	1.0	-1.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.6	-1.0	-0.4	-0.1	-1.3	-0.1	-0.8	-0.3
High blood pressure (siblings)	0.3	0.5	1.3	0.7	0.0	0.1	0.5	1.1	0.4	1.1
Forced vital capacity (FVC), Best measure	0.5	1.9	4.6	1.0	-0.7	-1.9	-0.4	-0.5	-1.8	-2.1
Body fat percentage	0.8	3.2	6.6	2.1	-0.0	2.5	1.2	1.9	2.6	0.5
Leg fat percentage (right)	1.0	3.8	7.8	2.8	-0.2	2.3	1.4	2.3	2.5	0.4
Arm fat-free mass (right)	0.3	1.5	5.8	-0.1	-1.7	-1.3	-0.3	-2.4	-0.3	0.5
Exposure to tobacco smoke outside home	0.5	0.6	1.5	-0.3	0.4	1.2	0.2	0.5	1.1	1.0
Comparative body size at age 10	0.4	1.0	1.9	1.4	1.4	0.3	-0.3	0.6	1.0	-1.3
Number of full brothers	0.6	0.7	2.6	0.4	-0.3	-1.1	0.3	-0.1	-1.0	-1.6
Worry too long after embarrassment	0.9	1.4	3.7	-0.7	-1.7	-1.0	-1.9	-0.6	-1.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.1	0.0	0.1	-0.4	0.5	0.5	0.1
Wheeze or whistling in the chest in last year	0.8	1.4	4.3	0.3	1.1	2.1	0.1	1.4	1.6	-0.2
Number of children fathered	0.7	0.8	1.6	-0.9	1.3	0.3	1.1	-0.2	1.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.4	-0.3	1.2	0.1	0.1	-0.0	-0.7	-0.9
Age at first live birth	0.5	0.8	2.5	1.5	0.2	0.5	0.5	0.3	1.6	-0.5
Pulse wave peak to peak time	0.3	0.3	0.9	0.2	-0.3	-0.1	-0.9	-0.4	-0.8	-0.6
Health satisfaction	0.6	0.8	1.8	-1.1	-0.6	-0.7	-0.0	-1.4	0.0	1.2
Shortness of breath walking on level ground	0.2	0.2	0.8	0.9	-0.9	-0.0	-0.1	0.1	-0.1	-0.3
Qualifications: College or University degree	0.4	1.3	3.9	1.2	0.8	1.3	-0.2	1.2	-0.2	-2.0
Eye problems/disorders: None of the above	0.4	0.4	0.9	0.9	0.8	-0.1	0.9	-0.5	0.6	-0.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.6	1.6	-0.0	-0.4	0.4	1.5	-0.3	-0.1
Emphysema/chronic bronchitis	2.1	2.3	6.4	-0.7	-1.1	0.0	-2.0	1.5	-2.5	-1.4
Medication for pain relief, constipation, heartburn	0.1	0.3	0.5	-0.1	0.6	-0.2	0.7	-0.3	0.7	0.6
Neck or shoulder pain in last month	1.3	1.8	5.1	-1.3	-0.9	-1.3	-1.7	-0.7	-2.3	0.4
Medication: Blood pressure	0.7	1.1	2.9	0.8	-0.5	-1.2	-0.4	-0.1	-1.6	-1.7
Angina (self-reported)	2.8	3.6	8.8	-1.0	-1.8	-1.5	-3.0	-0.1	-2.6	-1.8
Migraine (self-reported)	0.4	0.5	1.8	0.5	-1.3	0.0	0.4	-0.7	0.6	-0.5
Medication: Ibuprofen	0.8	1.0	2.0	-0.9	-1.4	-0.8	-0.8	-0.9	-1.0	-1.0
Medication: Allopurinol	0.2	0.3	1.2	0.3	-1.1	0.1	-0.5	0.7	-0.1	0.2
Medication: Omeprazole	0.1	0.2	0.5	-0.1	0.5	-0.2	0.5	-0.1	-0.1	-0.7
Medication: Seretide 50 evohaler	0.6	0.7	3.2	-0.9	-0.6	0.2	0.1	-0.1	0.4	1.8
Mean time to correctly identify matches	0.2	0.4	1.0	-0.3	0.0	-0.9	1.0	-0.8	-0.7	0.2
Heart disease (mother)	3.0	3.7	10.5	2.8	-0.6	1.9	-0.7	3.2	0.3	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.3	6.7	-0.7	-1.6	-2.1	-2.1	-1.5	-2.6	-1.6
Whole body fat mass	0.4	1.5	3.4	1.8	-0.8	1.5	0.6	0.8	1.8	0.3
Leg fat mass (right)	0.5	1.8	5.3	2.3	-1.0	1.4	0.8	1.0	1.6	0.1
Arm predicted mass (right)	0.3	1.6	6.2	-0.4	-1.5	-1.3	-0.5	-2.5	-0.3	0.5
Pulse rate, automated reading	0.0	0.1	0.2	-0.5	0.4	-0.2	0.3	-0.5	-0.3	-0.0
Alcohol intake frequency.	0.9	2.0	7.1	-1.9	-0.1	-1.5	-0.2	-2.7	-0.9	0.6
Comparative height size at age 10	0.4	2.0	6.5	-1.3	1.5	-0.3	0.9	-2.5	0.4	-1.6
Number of full sisters	0.8	0.9	3.3	-0.7	-0.2	1.1	-1.8	1.0	-0.5	0.4
Suffer from ‘nerves’	0.6	1.0	3.1	-0.2	-0.6	-1.3	-1.8	-0.5	-0.2	-1.2
Overall health rating	0.6	1.3	3.0	-1.4	-0.5	-0.9	-1.7	-0.3	-1.7	0.6
Chest pain or discomfort	1.2	1.7	5.3	0.1	0.7	1.9	-1.3	2.3	0.7	0.0
Had major operations	0.6	0.7	1.9	-0.8	0.4	1.4	-0.3	0.7	0.3	-1.1
Age at last live birth	0.2	0.3	0.8	0.9	0.1	-0.8	-0.3	0.6	-0.4	-0.5
Family relationship satisfaction	0.4	0.5	1.1	-0.4	-0.7	-0.4	-0.8	-1.1	-0.8	-0.8
Leg pain on walking	0.5	0.6	2.4	1.2	-0.3	0.3	-0.0	-0.5	-0.4	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.7	-0.1	-1.3	-0.3	-1.1	0.2	0.1	0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	-0.2	0.8	0.6	-0.3	-0.2	0.8	0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.8	-0.2	-0.3	0.2	0.6	0.2	0.1	0.9
Medication: Aspirin	0.5	0.6	1.6	-1.3	0.1	-0.2	-1.3	-0.3	-0.8	-0.3
Supplements: Vitamin C	0.5	0.6	1.9	0.1	-1.0	-0.5	-0.3	-0.2	-1.4	-0.9
Knee pain experienced in last month	0.9	1.4	4.4	-0.5	1.5	-0.3	2.1	-1.0	1.2	0.5
Hypertension (Self-reported)	0.5	1.4	4.4	0.4	2.1	0.0	2.1	0.5	0.7	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.5	0.3	-0.1	0.4	-0.3	0.7	-0.1	-0.3
Illnesses of father: Heart disease	1.1	1.6	4.8	-0.7	-0.3	-1.1	-1.2	-1.0	-2.2	-1.4
Illnesses of siblings: Diabetes	0.2	0.2	0.7	0.4	0.0	-0.5	0.8	-0.4	0.1	-0.4
Smoking status: Previous	0.4	0.6	1.7	0.7	-0.4	-0.7	0.3	1.3	-0.9	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.3	-0.8	0.0	-1.8	-0.5	-2.1	-1.2	-1.1
Whole body fat-free mass	0.3	1.6	4.6	0.3	-2.1	-1.3	-0.6	-2.0	-0.6	-0.1
Leg fat-free mass (right)	0.3	1.6	5.7	0.5	-2.4	-0.9	-0.9	-1.7	-0.9	-0.3
Arm fat percentage (left)	0.6	2.4	5.8	2.4	-0.9	1.8	0.5	1.9	1.6	0.5
Average weekly red wine intake	0.8	1.2	4.8	-0.3	-0.1	-0.3	-1.5	0.0	-0.9	-2.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	0.7	-1.1	-1.1	0.6	-0.7	-0.8	-0.3
Mood swings	0.1	0.1	0.4	0.3	-0.6	-0.3	-0.2	-0.4	-0.3	-0.3
Loneliness, isolation	0.8	1.2	2.7	-1.3	1.6	0.6	-0.1	-1.1	1.0	1.1
Long-standing illness, disability or infirmity	0.5	0.8	1.6	-0.3	1.3	0.7	0.9	1.2	0.7	0.8
Ever had bowel cancer screening	0.4	0.4	0.8	-0.8	0.5	0.0	-0.9	0.8	-0.3	-0.7
Diabetes diagnosed by doctor	0.2	0.2	0.7	0.8	-0.3	0.4	0.2	0.8	0.3	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.2	-1.0	-0.2	0.4	-0.8	0.5	-1.5	-0.9
Friendships satisfaction	0.1	0.1	0.5	-0.2	-0.7	0.4	-0.4	-0.3	0.2	0.2
Qualifications: nursing, teaching	1.1	1.7	3.4	1.4	0.2	1.6	1.3	1.8	1.5	0.0
Commuting to job workplace: Walk	0.7	0.8	2.1	0.1	-1.4	0.5	-0.3	0.6	0.9	1.5
Eye problems/disorders: Cataract	0.3	0.4	1.1	-0.6	-1.0	0.2	-0.9	-0.2	-0.0	0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.4	-1.5	1.6	-1.0	-0.5	-0.2	-0.6	-0.2
Medication for cholesterol	0.1	0.2	0.6	0.8	0.2	0.1	-0.4	0.5	0.0	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.0	0.3	-0.3	-0.6	-0.9	-1.0	-0.5	-1.0
Back pain experienced in last month	0.4	0.6	1.6	0.5	0.6	0.6	1.3	0.9	0.8	-0.0
Mineral and other dietary supplements	0.3	0.4	1.4	1.2	0.4	-0.8	-0.2	-0.1	0.3	-0.4
Breast cancer (self-reported)	0.6	0.8	2.6	-0.4	1.0	-0.8	0.9	-1.6	0.3	-0.3
Asthma (self-reported)	0.8	1.7	4.1	1.2	0.9	1.5	1.4	2.0	1.0	-0.4
Osteoporosis (self-reported)	1.0	1.3	3.3	-0.7	0.5	-0.7	-1.5	-0.6	-1.8	-1.3
Osteoarthritis (self-reported)	0.4	0.5	1.1	-0.5	0.6	-0.0	1.1	-0.6	-0.3	1.0
Medication: Aspirin	0.5	0.7	1.9	-1.3	-0.4	-0.1	-1.4	-0.2	-1.0	0.3
Medication: Gliclazide	1.6	1.8	4.6	0.7	2.0	0.5	1.7	0.3	2.1	0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	0.2	-1.2	0.8	-0.3	-0.5	1.0	1.2
Smoking status: Current	0.3	0.4	1.5	-0.6	0.7	0.2	0.3	-0.7	0.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.1	1.0	-0.7	-1.5	0.0	-0.2	-0.8	-1.4
Whole body water mass	0.3	1.5	4.5	0.3	-2.1	-1.2	-0.5	-1.9	-0.5	0.1
Leg predicted mass (right)	0.3	1.6	5.6	0.5	-2.4	-0.9	-1.0	-1.7	-0.9	-0.3
Arm fat mass (left)	0.3	1.3	4.0	2.0	-1.4	1.0	0.1	0.9	1.1	0.4
Number of self-reported non-cancer illnesses	0.4	0.7	2.6	-0.2	0.4	1.6	0.9	1.2	0.3	-0.1
Average weekly champagne plus white wine intake	0.8	1.1	3.3	-0.5	1.6	-0.1	1.0	-0.5	1.8	0.2
Miserableness	1.0	1.7	4.7	-0.2	-1.1	-1.6	-1.7	-0.6	-2.2	-0.3
Guilty feelings	0.4	0.6	1.5	-0.2	1.2	0.7	-0.7	0.6	0.3	-1.0
Wears glasses or contact lenses	1.1	1.2	3.3	-1.2	0.7	0.6	-1.6	-0.6	-0.3	-1.8
Ever taken oral contraceptive pill	0.5	0.6	2.1	0.2	0.0	-0.8	-0.1	-0.7	-1.5	-0.8
Hearing aid user	1.6	1.8	4.6	-1.6	-0.8	-0.2	-2.1	-0.8	-1.6	-1.3
Mother’s age at death	2.6	3.3	6.3	1.1	-0.3	2.2	1.5	2.1	2.5	2.0
Financial situation satisfaction	0.1	0.1	0.2	-0.4	0.4	0.1	0.2	-0.2	0.2	-0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.7	-0.8	0.1	0.2	-0.2	-0.4	-0.0	0.0
Commuting to job workplace: Public transport	0.7	0.8	1.5	1.2	0.3	0.7	1.2	1.0	1.0	-0.4
Eye problems/disorders: Glaucoma	0.8	1.0	3.0	0.9	-0.8	1.7	0.6	1.2	0.6	-0.0
Medication: Blood pressure	0.7	1.3	4.2	0.5	1.6	0.4	2.1	0.3	1.2	0.3
Pain type(s) experienced in last month: Hip pain	1.6	2.0	5.2	0.0	2.3	1.3	1.9	0.9	1.5	0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.7	3.7	-1.9	-0.6	0.7	-0.4	-0.6	-0.5	0.1
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.1	-0.5	-0.5	0.1	-0.2	-0.8	0.2
Medication: Bendroflumethiazide	0.9	1.4	3.5	1.0	0.7	0.8	1.9	0.5	1.5	1.4
Medication: Paracetamol	0.7	1.2	3.2	1.3	0.6	1.8	0.9	1.0	0.7	-0.7
Medication: Lisinopril	1.0	1.3	3.6	-0.2	1.7	0.1	1.9	-1.1	1.2	-0.3
Medication: Atorvastatin	0.6	0.7	1.2	1.1	-0.5	-0.9	-0.7	0.7	-1.0	-0.7
Illnesses of father: High blood pressure	0.4	0.5	0.8	0.2	0.8	-0.3	0.7	0.9	-0.7	-0.8
Alcohol drinker status: Never	1.9	2.2	6.7	-2.6	-0.8	-0.9	-1.7	-1.7	-1.4	0.3
Ever smoked	0.4	0.7	1.9	0.5	1.0	0.5	1.4	0.7	0.6	0.8
Basal metabolic rate	0.2	1.2	4.6	0.6	-2.1	-0.9	-0.5	-1.6	-0.3	-0.0
Leg fat percentage (left)	0.9	3.4	6.2	2.4	0.0	2.2	1.5	2.0	2.5	0.8
Arm fat-free mass (left)	0.3	1.6	5.0	0.2	-2.2	-1.1	-0.3	-2.1	0.0	0.7
Number of operations (self-reported)	0.6	0.9	3.9	-2.0	0.6	1.0	-0.5	0.1	-0.8	0.6
Average weekly beer plus cider intake	1.7	2.5	5.0	-0.9	-2.2	-1.7	-1.3	-0.9	-2.2	1.3
Irritability	0.7	1.2	2.7	0.3	-1.6	-1.0	-1.4	-0.5	-1.4	0.3
Risk taking	1.1	1.6	3.7	0.1	1.7	1.8	0.5	0.8	0.9	-1.9
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.1	-0.5	1.4	0.3	1.4	-0.7	1.2	-0.6
Fractured/broken bones in last 5 years	2.0	2.6	6.6	-1.9	-0.0	-1.4	-1.5	-2.6	-1.9	-0.2
Age started oral contraceptive pill	0.8	1.0	3.3	-1.8	-0.2	-0.2	0.1	-1.7	-0.4	0.5
Diastolic blood pressure, automated reading	1.2	3.6	6.8	1.2	0.1	1.6	2.6	1.2	2.6	2.6
Ever depressed for a whole week	0.9	1.1	5.6	-0.4	-0.4	-1.3	0.3	-2.4	-0.0	0.2
Unable to work because of sickness or disability	0.4	0.5	1.1	-0.7	0.8	-0.6	0.1	1.0	-1.0	0.6
Commuting to job workplace: Cycle	0.9	1.1	4.7	0.6	0.2	2.2	0.6	1.1	0.9	-0.3
Myopia	2.3	3.3	7.4	-0.1	-1.2	-2.2	-2.5	-0.2	-2.7	-1.8
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.4	-0.1	-1.8	-0.0	-1.3	-0.7	-0.2	0.1
Cholesterol lowering medication	0.5	0.8	1.9	-1.2	-0.7	-0.8	0.3	-0.6	-1.4	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.7	0.8	0.4	0.9	0.6	0.2	-0.4
Pain experienced in last month	0.6	0.9	2.2	0.6	-0.7	-1.2	-1.3	-0.3	-1.5	-0.5
Supplements: Calcium	0.3	0.4	1.2	-1.1	-0.1	0.9	-0.4	0.4	-0.1	-0.4
Basal cell carcinoma (self-reported)	0.3	0.3	1.1	-0.8	0.7	-0.2	-1.0	0.2	0.5	0.0
Heart attack/myocardial infarction (self-reported)	0.9	1.1	4.6	-0.1	-0.8	-0.2	-2.1	0.2	-1.6	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.3	-1.3	0.9	-0.4	-0.5	-0.9	-0.3	-1.5
Heart disease (siblings)	0.2	0.2	0.4	0.5	-0.6	0.1	-0.4	0.5	0.0	0.6
Alcohol drinker status: Previous	1.1	1.3	3.1	-1.8	0.6	-1.5	-0.7	-1.1	-1.1	0.4
Pack years of smoking	0.5	0.7	2.0	0.5	1.4	0.3	1.4	0.8	0.5	-0.3
Impedance of whole body	0.4	1.8	8.3	-1.1	2.9	1.1	0.4	0.5	0.9	-0.8
Leg fat mass (left)	0.4	1.6	4.3	2.1	-1.0	1.4	0.8	0.9	1.6	0.5
Arm predicted mass (left)	0.3	1.3	3.8	0.3	-1.9	-0.8	-0.0	-2.0	0.3	0.6