TWAS hub - NR1D1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.2510	0.1090	0.0058	0.002	NA	0.027	NA	0.046	0.280	NA	6.1e-02	NA	2.1e-02
2	NTR	Blood	0.0493	0.0168	0.0006	0.007	0.016	0.024	0.015	0.018	0.002	4.3e-06	3.1e-08	7.8e-06	9.5e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood White Count	26.1	193.5	306.2	17.5	9.0
Asthma (self-reported)	15.5	30.9	58.8	7.7	1.7
Asthma	14.5	28.6	54.6	7.4	1.6
Respiratory disease	14.4	32.0	61.3	7.8	1.7
Allergy	9.7	22.4	44.5	-6.7	-0.5
Medication: Ventolin 100micrograms inhaler	9.0	11.6	21.4	4.6	1.3
Financial situation satisfaction	7.5	9.4	17.0	-1.3	4.1
HDL Cholesterol	7.3	12.2	23.8	-4.9	-0.8
Ulcerative Colitis	6.9	10.0	12.7	-3.6	2.7
Irritable Bowel Disease (IBD)	5.7	13.6	24.7	-5.0	1.6
Father’s age at death	5.6	7.5	11.0	-3.3	-2.0
Myopia	5.3	7.7	11.6	3.4	-2.0
Tinnitus: Yes, but not now, but have in the past	4.9	5.2	8.6	-2.9	1.4
Hayfever, allergic rhinitis or eczema	4.7	10.3	20.6	4.5	-0.0
Wheeze or whistling in the chest in last year	4.5	8.1	8.9	2.7	3.0
Gout (self-reported)	4.3	5.9	9.2	-1.6	-3.0
Ulcerative Colitis (UC)	4.2	7.9	13.1	-3.6	1.6
Chronic bronchitis/emphysema (father)	4.2	4.9	9.7	3.1	-0.0
Coronary Artery Disease (CAD)	4.0	4.8	6.5	-1.8	2.5
Current tobacco smoking	4.0	6.6	11.3	1.4	3.4
Taking other prescription medications	4.0	6.1	10.7	3.3	1.2
Hayfever/allergic rhinitis (self-reported)	3.8	5.1	9.8	3.1	-0.6
Crohns Disease (2017)	3.5	7.6	14.6	-3.8	0.9
Illnesses of mother	3.5	4.3	4.3	2.1	-2.0
Ever had bowel cancer screening	3.5	4.1	7.7	-2.8	-0.8
Allergy or Eczema	3.4	9.0	18.0	4.2	0.3
Alcohol usually taken with meals	3.4	5.5	5.9	-2.4	-2.3
Number of self-reported non-cancer illnesses	3.4	5.8	6.5	2.5	2.3
Wears glasses or contact lenses	3.4	3.9	7.6	-2.8	-0.5
Hearing aid user	3.3	3.7	4.4	-2.1	1.7
Emphysema/chronic bronchitis	3.2	3.6	6.3	2.5	0.9
Ever depressed for a whole week	3.2	4.0	5.9	2.4	1.4
Primary Biliary Cirrhosis	3.1	4.5	8.4	-2.9	0.7
Medication: Seretide 50 evohaler	3.1	3.6	5.0	1.5	2.2
Bipolar Disorder (2018)	3.0	4.8	9.5	3.1	-0.1
Major Depression (MDD)	3.0	3.6	3.7	1.9	1.9
Breast Cancer	3.0	7.1	13.4	3.7	-0.9
Knee pain experienced in last month	3.0	4.6	7.8	-1.2	2.8
Smoking status: Current	3.0	4.7	7.7	1.3	2.8
Birth weight	2.9	6.3	12.4	3.5	-0.4
Chest pain or discomfort	2.9	4.2	8.3	-0.1	2.9
Bipolar Disorder or Schizophrenia	2.8	6.7	12.0	3.5	-1.2
Townsend deprivation index at recruitment	2.8	4.0	4.5	2.1	1.8
Eye problems/disorders: None of the above	2.8	3.3	6.3	2.5	-0.5
Number of full brothers	2.7	3.4	6.9	2.6	0.1
Ever had hysterectomy (womb removed)	2.6	2.9	5.6	-2.4	0.5
Mouth/teeth dental problems: Dentures	2.6	4.4	6.9	2.6	1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	5.4	0.6	-2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.3	9.2	-3.0	-1.2
Supplements: Vitamin C	2.4	2.8	5.2	2.3	0.7
Friendships satisfaction	2.4	3.0	5.5	2.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	7.3	-2.7	0.5
Rheumatoid Arthritis	2.3	3.2	5.6	-2.4	0.8
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	3.0	-1.7	1.4
Number of incorrect matches in round	2.3	3.9	6.1	2.5	-1.3
Average weekly red wine intake	2.3	3.4	6.7	-2.6	-0.4
Loneliness, isolation	2.3	3.1	3.9	1.5	2.0
Time employed in main current job	2.2	2.5	3.3	-1.8	-1.3
Falls in the last year	2.2	3.0	5.2	-2.3	0.9
Medication: Allopurinol	2.2	3.0	5.5	-0.6	-2.4
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	4.6	2.2	-0.8
Commuting to job workplace: Public transport	2.2	2.6	5.0	-2.2	0.5
Had menopause	2.1	2.7	5.3	-0.2	2.3
Qualifications: None of the above	2.1	4.5	6.5	1.6	2.5
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.3	3.6	-1.8	1.9
Average weekly champagne plus white wine intake	2.1	2.9	5.8	-0.1	-2.4
Miserableness	2.1	3.6	6.4	0.8	2.5
Pain type(s) experienced in last month: Hip pain	2.1	2.6	4.4	-2.1	-0.9
HbA1C	1.9	2.1	3.8	-2.0	0.6
Blood Eosinophil Count	1.9	15.0	29.2	-0.9	5.4
Hand grip strength (left)	1.8	4.7	7.0	2.6	-1.6
Hand grip strength (right)	1.8	4.9	5.0	2.2	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.6	6.5	-2.2	-2.5
Alcohol intake frequency.	1.8	4.1	8.0	2.8	0.5
Blood Platelet Count	1.7	20.0	26.6	-5.2	3.6
Number of treatments/medications taken	1.7	3.1	4.1	1.4	2.0
Number of children fathered	1.7	1.9	3.8	0.2	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.1	4.0	2.0	-0.4
Number of operations (self-reported)	1.7	2.5	3.6	-1.9	1.2
Sitting height	1.6	11.5	15.8	2.7	-4.0
Medication: Simvastatin	1.6	2.3	4.6	-0.2	2.1
Forced expiratory volume in 1-second (FEV1)	1.6	5.5	6.9	-2.0	-2.6
Suffer from ‘nerves’	1.6	2.5	2.9	-1.4	1.7
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	3.1	-0.9	1.8
Basal cell carcinoma (self-reported)	1.6	1.9	3.4	1.8	0.6
Schizophrenia (2018)	1.5	3.2	4.0	2.0	-1.6
Vitamin and mineral supplements	1.5	2.0	2.8	-1.7	-1.1
Trunk fat percentage	1.5	5.8	9.8	1.4	3.1
Relative age voice broke	1.5	2.3	4.3	-0.5	-2.1
Exposure to tobacco smoke outside home	1.5	2.0	2.3	1.5	1.3
Medication: Ibuprofen	1.5	1.8	3.2	-0.6	-1.8
Age started oral contraceptive pill	1.5	1.9	3.5	-1.9	-0.6
Multivitamins +/- minerals	1.4	1.8	3.0	1.7	0.8
Tense / ‘highly strung’	1.4	2.4	4.7	-0.3	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	2.8	0.9	1.7
Migraine (self-reported)	1.4	1.7	3.4	0.1	1.9
Medication: Omeprazole	1.4	1.6	1.9	-1.2	1.4
Diabetes diagnosed by doctor	1.4	2.2	4.4	0.2	2.1
Back pain experienced in last month	1.4	2.1	4.1	-2.0	0.3
Breast cancer (self-reported)	1.4	1.7	3.3	0.0	1.8
Ovarian Cancer	1.3	1.7	2.4	1.6	1.0
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	3.0	-1.7	-0.5
High blood pressure (mother)	1.3	1.9	3.0	-1.7	0.9
Arm fat percentage (right)	1.3	5.0	7.2	1.7	2.7
Noisy workplace	1.3	1.7	3.1	-0.4	1.8
Medication for pain relief, constipation, heartburn	1.3	2.2	2.5	1.6	-1.4
Qualifications: nursing, teaching	1.3	2.1	3.9	-0.5	-2.0
Guilty feelings	1.3	1.9	3.8	2.0	0.0
Irritability	1.3	2.2	2.8	-1.2	-1.7
Alcohol drinker status: Previous	1.3	1.5	2.3	1.5	-0.9
Lupus	1.2	1.8	3.6	-1.9	-0.1
Schizophrenia (2014)	1.2	2.6	4.9	2.2	-0.6
Maternal smoking around birth	1.2	1.7	3.3	-0.3	1.8
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.6	-1.6	0.8
Arm fat percentage (left)	1.2	5.0	7.8	1.5	2.8
Commuting to job workplace: Cycle	1.2	1.4	1.9	-0.9	-1.4
Pain experienced in last month	1.2	1.9	2.9	1.0	-1.7
Serious illness, injury or assault to yourself	1.1	1.3	2.5	1.6	0.4
Mouth/teeth dental problems	1.1	1.6	3.1	0.4	-1.8
Body fat percentage	1.1	4.4	8.0	1.0	2.8
Shortness of breath walking on level ground	1.1	1.3	2.2	-0.6	1.5
Overall health rating	1.1	2.4	4.7	0.2	2.2
Osteoarthritis (self-reported)	1.1	1.4	2.7	-0.3	1.6
Medication: Bendroflumethiazide	1.1	1.6	3.1	-0.2	1.8
Alcohol drinker status: Never	1.1	1.4	2.7	1.6	-0.1
Schizophrenia vs Biploar Disorder	1.0	1.3	2.5	-1.6	-0.3
Body Mass Index (BMI) (2010)	1.0	1.3	2.6	0.2	-1.6
Lung FEV1/FVC ratio	1.0	4.9	8.6	-2.9	-1.1
Had other major operations	1.0	1.2	2.2	-0.5	1.5
Forced vital capacity (FVC)	1.0	3.7	5.5	-1.4	-2.4
Heart attack	1.0	1.3	1.7	1.3	1.0
Impedance of arm (right)	1.0	4.8	4.9	2.2	2.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.1	-0.5	1.5
Impedance of arm (left)	1.0	4.8	6.4	1.8	2.5
Pulse wave reflection index	1.0	1.2	1.9	0.7	1.4
Forced vital capacity (FVC), Best measure	1.0	3.7	5.7	-1.3	-2.4
Qualifications: College or University degree	1.0	3.1	3.4	-1.7	-1.8
Commuting to job workplace: Car/motor vehicle	1.0	1.2	1.8	0.7	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	1.4	-1.0	1.2
Eye problems/disorders: Cataract	1.0	1.1	1.7	-1.3	0.8
Risk taking	1.0	1.5	3.0	-1.7	0.3
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.2	1.5	0.6
Depressed Affect (Nagel 2018)	0.9	1.9	3.3	0.8	1.8
Prostate Cancer	0.9	1.3	1.5	1.1	-1.2
Mean Putamen Volume	0.9	1.0	1.4	1.2	0.8
Average weekly fortified wine intake	0.9	1.0	1.5	0.7	-1.2
Alcohol intake versus 10 years previously	0.9	1.4	2.7	0.4	1.6
Medication: Lansoprazole	0.9	1.0	1.7	-0.5	1.3
Medication: Amlodipine	0.9	1.3	1.9	-0.8	-1.4
Angina (self-reported)	0.9	1.2	1.2	-1.1	1.1
Family relationship satisfaction	0.9	1.2	1.8	1.3	0.7
Medication: Aspirin	0.9	1.2	1.6	-1.3	0.9
Illnesses of father: Heart disease	0.9	1.2	1.4	1.2	1.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.9	1.4	0.5
Illnesses of father: High blood pressure	0.9	1.2	2.3	-1.5	0.0
Average weekly beer plus cider intake	0.9	1.2	2.4	-0.4	1.5
Blood Red Count	0.8	7.9	15.8	4.0	0.1
Height	0.8	15.2	23.9	4.9	-2.5
Supplements: Zinc	0.8	0.8	1.2	-0.7	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.5	-0.7	-1.2
Supplements: Glucosamine	0.8	1.0	2.0	0.0	1.4
Trunk fat mass	0.8	3.4	4.5	1.5	2.1
Diabetes (self-reported)	0.8	1.2	1.4	1.0	1.2
Medication: Ramipril	0.8	1.0	1.4	0.8	1.2
Loud music exposure frequency	0.8	0.9	1.0	-0.9	1.0
Medication: Paracetamol	0.8	1.3	1.8	-0.9	1.4
Leg fat percentage (right)	0.8	2.8	5.6	0.2	2.4
Neck or shoulder pain in last month	0.8	1.1	2.2	-0.3	1.5
Crohns Disease (2012)	0.7	1.1	2.2	-1.5	-0.1
Lung FVC	0.7	3.3	6.6	-2.6	-0.3
Chronotype (morning person)	0.7	1.6	2.8	-1.7	-0.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.6	1.3	0.5
Medication: Co-codamol	0.7	0.8	1.2	-0.6	1.1
Fed-up feelings	0.7	1.2	1.9	-0.7	1.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	0.9	0.9	0.9
Exposure to tobacco smoke at home	0.7	0.8	1.6	0.0	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.8	1.4	0.5
Mother’s age at death	0.7	0.9	1.8	-1.3	-0.3
Medication: Paracetamol	0.7	1.1	1.9	-1.4	0.6
Alzheimer’s Disease (including proxy)	0.6	0.8	1.5	-1.2	0.4
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.0	-0.2	-1.7
Triglycerides	0.6	1.0	1.4	0.7	1.2
Average weekly spirits intake	0.6	0.7	1.2	-0.5	1.1
Angina	0.6	0.8	1.1	-1.1	0.7
Medication: Levothyroxine sodium	0.6	1.0	1.1	1.0	1.0
Waist circumference	0.6	2.1	4.1	-0.1	2.0
Pain all over the body in last month	0.6	0.7	1.0	1.0	0.5
Happiness	0.6	0.7	1.1	0.6	1.0
Medication: Cholesterol lowering	0.6	1.0	1.3	-0.8	1.1
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	1.1	0.3
Arm fat mass (right)	0.6	2.3	2.9	1.3	1.7
Health satisfaction	0.6	0.7	0.8	-0.8	0.9
Heart disease (mother)	0.6	0.7	0.8	0.9	-0.8
Whole body fat mass	0.6	2.5	3.8	1.1	2.0
Leg fat mass (right)	0.6	2.3	4.3	0.5	2.1
Medication: Lisinopril	0.6	0.8	1.6	-1.3	0.1
Leg fat percentage (left)	0.6	2.0	4.1	-0.0	2.0
Pack years adult smoking proportion	0.5	0.7	1.3	0.4	1.1
Trunk fat-free mass	0.5	3.1	5.0	1.1	-2.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	-0.1	-1.1
Lung cancer (father)	0.5	0.5	0.6	0.7	0.7
Trunk predicted mass	0.5	2.9	4.8	1.1	-2.2
Length of working week for main job	0.5	0.5	1.0	-1.0	0.2
Blood clot in the leg (DVT)	0.5	0.6	0.6	0.8	0.8
Headache pain in last month	0.5	0.8	1.4	-0.4	1.2
Pulse wave peak to peak time	0.5	0.6	0.7	-0.8	-0.8
Comparative height size at age 10	0.5	2.8	5.5	2.4	0.0
Illnesses of siblings: Diabetes	0.5	0.6	0.7	-0.8	0.8
Arm fat mass (left)	0.5	2.1	3.0	1.1	1.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.9	1.0	0.6
Leg fat mass (left)	0.5	1.8	3.4	0.4	1.9
Smoking Status	0.4	1.0	1.3	0.9	1.1
Hearing difficulty/problems: Yes	0.4	0.6	1.1	-0.4	1.0
Diabetes (father)	0.4	0.5	0.8	-0.9	-0.3
Severe depression (siblings)	0.4	0.4	0.8	0.9	-0.1
Age when periods started (menarche)	0.4	0.9	1.6	0.5	-1.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-1.0	0.2
Qualifications: CSEs or equivalent	0.4	0.6	1.1	0.1	1.1
Financial difficulties in last 2 years	0.4	0.5	0.7	0.9	0.5
Fluid intelligence score	0.4	0.9	1.3	-0.7	-1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.2	0.1	-1.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.3	0.1	-1.2
Number of full sisters	0.4	0.5	1.0	1.0	-0.0
Long-standing illness, disability or infirmity	0.4	0.7	0.8	0.8	0.9
Osteoporosis (self-reported)	0.4	0.5	0.8	-0.4	0.9
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.6	0.8	-0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	0.3	0.9
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.0	-0.5	-1.4
Cholesterol lowering medication	0.4	0.6	1.3	0.2	1.1
Heart disease (siblings)	0.4	0.5	0.7	0.6	-0.8
Pack years of smoking	0.4	0.6	0.9	0.4	1.0
Impedance of whole body	0.4	1.9	3.1	0.9	1.7
Alzheimer’s Disease (in father)	0.3	0.3	0.4	-0.6	-0.5
Reaction Time	0.3	0.6	1.0	1.0	-0.4
LDL Cholesterol	0.3	0.5	1.1	-1.0	0.0
Neuroticism (2016)	0.3	0.5	1.0	1.0	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	0.8	-0.4
Waist Hip Ratio (WHR)	0.3	1.6	2.2	-0.9	1.5
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.4	-0.5	0.6
High blood pressure	0.3	0.9	1.5	0.5	1.2
Medication: Atenolol	0.3	0.4	0.8	0.0	0.9
Body mass index (BMI)	0.3	1.2	2.4	0.2	1.6
Nervous feelings	0.3	0.6	0.7	0.9	0.6
Standing height	0.3	3.1	3.3	1.8	-1.7
Birth weight of first child	0.3	0.5	0.8	0.9	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.8	0.9	-0.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	0.4	0.7
Medication: Blood pressure	0.3	0.5	0.9	-0.2	0.9
Mean time to correctly identify matches	0.3	0.6	0.8	0.6	-0.9
Had major operations	0.3	0.3	0.7	0.8	0.1
Smoking status: Previous	0.3	0.5	0.8	-0.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	0.9	0.9	-0.7
Whole body fat-free mass	0.3	1.6	1.8	1.2	-1.3
Mood swings	0.3	0.6	1.0	1.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.4	0.6	0.5
Medication: Aspirin	0.3	0.3	0.6	-0.3	0.8
Illnesses of father: None of the above (group 1)	0.3	0.3	0.6	-0.8	0.0
Whole body water mass	0.3	1.5	1.8	1.1	-1.3
Ever smoked	0.3	0.6	0.8	0.6	0.9
Neuroticism (Nagel 2018)	0.2	0.5	1.0	0.3	1.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.7	-0.2
Heel T-Score	0.2	1.3	2.5	-0.3	1.6
Systolic Blood Pressure	0.2	1.2	1.9	1.4	0.7
Tanning	0.2	2.1	3.3	1.0	1.8
Sensitivity / hurt feelings	0.2	0.3	0.3	0.5	0.6
Relative age of first facial hair	0.2	0.4	0.9	-0.1	-0.9
Medication for hormone replacement therapy	0.2	0.2	0.3	0.5	-0.4
Leg fat-free mass (left)	0.2	1.0	1.8	1.3	0.4
Stomach or abdominal pain in last month	0.2	0.3	0.5	-0.4	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.3	-0.5	-0.5
Leg predicted mass (left)	0.2	0.9	1.6	1.3	0.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	0.7	-0.2
Illnesses of siblings	0.2	0.3	0.4	-0.6	0.6
Weight	0.2	0.8	1.0	1.0	0.8
Depression (self-reported)	0.2	0.2	0.3	0.6	-0.2
Prospective memory result	0.2	0.2	0.2	0.4	-0.5
Breastfed as a baby	0.2	0.2	0.3	0.4	-0.6
Peak expiratory flow (PEF)	0.2	0.4	0.7	-0.4	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.9	0.1
Arm fat-free mass (right)	0.2	1.1	2.2	0.0	-1.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.2	-0.5	0.4
Arm predicted mass (right)	0.2	1.2	2.3	-0.1	-1.5
Pulse rate, automated reading	0.2	0.8	1.4	1.2	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	-0.5	-0.3
Hypertension (Self-reported)	0.2	0.4	0.8	0.9	0.3
Mineral and other dietary supplements	0.2	0.2	0.4	0.3	-0.6
Medication: Gliclazide	0.2	0.2	0.4	-0.1	-0.6
Medication: Blood pressure	0.2	0.3	0.7	0.8	0.0
Medication: Atorvastatin	0.2	0.2	0.4	-0.6	0.0
Basal metabolic rate	0.2	1.1	1.5	1.2	-0.8
Arm fat-free mass (left)	0.2	1.3	2.1	0.7	-1.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.2	0.4	-0.4
Fractured/broken bones in last 5 years	0.2	0.3	0.4	-0.7	-0.3
Arm predicted mass (left)	0.2	1.3	2.2	0.5	-1.5
Depression (Nagel 2018)	0.1	0.2	0.2	0.4	-0.5
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	-0.2	0.8
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.0	0.6
Neuroticism	0.1	0.1	0.1	0.3	0.4
Systolic blood pressure, automated reading	0.1	0.3	0.3	0.6	0.6
Medication: Metformin	0.1	0.1	0.1	-0.2	0.4
Diabetes (mother)	0.1	0.1	0.2	-0.4	0.1
Impedance of leg (right)	0.1	0.3	0.7	0.0	0.8
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.4	-0.5
Neuroticism score	0.1	0.2	0.4	0.6	0.1
Hip circumference	0.1	0.4	0.5	0.5	0.7
Worrier / anxious feelings	0.1	0.2	0.3	0.5	0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.2	-0.4
Pulse rate	0.1	0.2	0.3	0.6	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	0.5	0.0
Hair/balding pattern: Pattern 4	0.1	0.3	0.3	0.5	-0.5
Worry too long after embarrassment	0.1	0.2	0.4	0.6	-0.0
Age at last live birth	0.1	0.2	0.3	-0.6	-0.2
Leg pain on walking	0.1	0.1	0.2	-0.2	0.5
Leg fat-free mass (right)	0.1	0.7	1.4	1.2	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.0	-0.4
Medication for cholesterol	0.1	0.1	0.2	-0.4	0.1
Leg predicted mass (right)	0.1	0.7	1.4	1.2	-0.0
High cholesterol (Self-reported)	0.1	0.3	0.4	-0.3	0.6
Diastolic blood pressure, automated reading	0.1	0.4	0.8	0.2	0.9
Unable to work because of sickness or disability	0.1	0.2	0.3	-0.2	0.5
Worry (Nagel 2018)	0.0	0.0	0.1	-0.3	-0.0
Age at First Birth	0.0	0.0	0.0	0.0	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.0	0.1	-0.1
BMI	0.0	0.2	0.2	-0.5	0.4
Cardiovascular Disease	0.0	0.0	0.0	0.1	0.1
Hypothyroidism (self reported)	0.0	0.0	0.1	-0.2	0.2
Hair Pigment	0.0	0.2	0.4	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	-0.3	0.1
Impedance of leg (left)	0.0	0.1	0.1	-0.3	0.2
Past tobacco smoking	0.0	0.0	0.0	0.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	-0.1	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	-0.1	0.2
Number of live births	0.0	0.1	0.1	-0.3	0.0
Glaucoma (self-reported)	0.0	0.0	0.1	-0.0	0.2
High blood pressure (siblings)	0.0	0.1	0.1	-0.2	0.3
Comparative body size at age 10	0.0	0.1	0.2	-0.5	0.1
Age at first live birth	0.0	0.0	0.0	-0.1	-0.2
Commuting to job workplace: Walk	0.0	0.0	0.1	0.0	0.2
Ever taken oral contraceptive pill	0.0	0.0	0.0	-0.2	-0.2
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.3	0.1
Supplements: Calcium	0.0	0.1	0.1	0.3	0.1

Hub : Genes

NR1D1

Models

Trait associations