TWAS hub - NR1I2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.096	0.047	0.00066	0.061	0.05	0.047	NA	0.042	0.0002	0.00069	0.0011	NA	0.0018
2	TCGA	Pancreatic Adenocarcinoma	0.114	0.051	0.00140	0.012	0.08	0.021	NA	0.034	0.0960	0.00030	0.0430	NA	0.0150

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Risk taking	7.4	10.9	14.3	-3.8	-2.7
Arm fat mass (right)	5.5	22.5	31.0	3.7	5.6
Mean Putamen Volume	5.4	6.2	9.5	3.1	1.7
Body mass index (BMI)	5.4	23.1	31.9	3.8	5.7
Arm fat mass (left)	5.3	21.8	28.9	3.8	5.4
Trunk fat mass	5.1	22.0	30.0	3.7	5.5
Nervous feelings	5.1	9.6	10.0	3.0	3.2
Weight	5.1	25.0	34.2	4.0	5.8
Whole body fat mass	5.1	21.1	29.8	3.5	5.5
Hip circumference	5.0	21.7	29.7	3.7	5.4
Guilty feelings	5.0	7.5	9.8	3.1	2.3
Lupus	4.9	7.4	8.5	-2.5	-2.9
Neck or shoulder pain in last month	4.8	6.8	10.1	-3.2	-1.9
Trunk fat percentage	4.7	18.8	25.3	3.5	5.0
Medication: Allopurinol	4.7	6.3	7.6	2.2	2.7
Medication: Ramipril	4.6	5.9	9.2	3.0	1.6
Arm fat percentage (right)	4.6	18.0	24.9	3.3	5.0
BMI	4.5	26.1	37.0	3.9	6.1
Body fat percentage	4.5	17.9	24.0	3.4	4.9
Arm fat percentage (left)	4.5	18.1	24.6	3.4	5.0
Illnesses of mother	4.4	5.4	6.7	2.0	2.6
Impedance of leg (right)	4.3	20.8	27.4	-3.8	-5.2
Neuroticism	4.2	10.2	13.1	3.6	2.7
Sensitivity / hurt feelings	4.2	7.1	10.9	3.3	1.8
Gout (self-reported)	4.1	5.7	7.4	2.0	2.7
Leg fat-free mass (right)	4.1	21.9	24.9	4.3	5.0
Leg predicted mass (left)	4.0	21.1	24.8	4.2	5.0
Blood White Count	3.9	28.6	42.9	6.5	3.8
Relative age voice broke	3.9	6.0	9.9	-1.5	-3.1
Leg predicted mass (right)	3.9	21.1	24.1	4.2	4.9
Leg fat mass (left)	3.9	15.0	20.3	3.1	4.5
Leg fat-free mass (left)	3.8	20.1	23.9	4.0	4.9
Time employed in main current job	3.8	4.4	6.4	2.5	1.5
Loneliness, isolation	3.8	5.2	8.5	2.9	1.4
Father’s age at death	3.7	5.0	8.1	-2.8	-1.4
Number of full sisters	3.7	4.5	4.8	-2.0	-2.2
Medication: Bendroflumethiazide	3.7	5.7	7.7	2.8	1.9
Waist circumference	3.6	13.1	17.3	3.0	4.2
Leg fat mass (right)	3.6	14.0	19.7	2.9	4.4
Long-standing illness, disability or infirmity	3.6	5.6	7.5	2.7	1.9
Impedance of leg (left)	3.5	16.8	23.4	-3.2	-4.8
Allergy	3.5	8.1	9.2	3.0	2.6
Neuroticism score	3.5	7.4	10.2	3.2	2.1
Relative age of first facial hair	3.4	7.0	7.7	-2.8	-2.5
Multivitamins +/- minerals	3.3	4.2	6.0	1.6	2.4
Wears glasses or contact lenses	3.3	3.8	6.2	-2.5	-1.2
Neuroticism (Nagel 2018)	3.2	7.5	9.3	3.1	2.4
Mouth/teeth dental problems: Dentures	3.2	5.5	8.2	2.9	1.6
Fed-up feelings	3.0	5.4	8.9	3.0	1.4
Medication: Aspirin	3.0	4.0	4.8	1.8	2.2
Basal metabolic rate	3.0	16.7	21.4	3.5	4.6
Alzheimer’s Disease (in father)	2.9	3.2	4.0	1.5	2.0
Allergy or Eczema	2.9	7.6	12.4	-3.5	-1.7
Hayfever, allergic rhinitis or eczema	2.9	6.3	9.0	-3.0	-1.9
Mouth/teeth dental problems: Bleeding gums	2.9	3.7	6.0	-2.5	-1.2
Medication: Amlodipine	2.9	4.1	5.6	2.4	1.6
Commuting to job workplace: Cycle	2.9	3.5	4.3	-1.6	-2.1
Qualifications: CSEs or equivalent	2.8	3.7	5.4	2.3	1.4
Medication: Blood pressure	2.6	4.6	6.3	2.5	1.7
Whole body fat-free mass	2.6	14.6	18.4	3.3	4.3
Pain experienced in last month	2.6	4.3	6.8	2.6	1.3
Depressed Affect (Nagel 2018)	2.5	5.3	8.7	3.0	1.3
Chest pain or discomfort	2.5	3.6	5.1	-1.5	-2.2
Medication: Aspirin	2.5	3.2	3.5	1.9	1.7
Whole body water mass	2.5	14.2	18.3	3.2	4.3
Leg fat percentage (left)	2.4	8.8	11.9	2.4	3.5
Ever depressed for a whole week	2.4	2.9	4.5	-1.1	-2.1
Arm predicted mass (left)	2.4	12.2	16.3	2.8	4.0
Bipolar Disorder (2018)	2.3	3.7	3.8	-1.9	-2.0
HDL Cholesterol	2.3	3.9	5.4	-2.3	-1.5
Length of working week for main job	2.3	2.6	3.0	1.7	1.5
Angina (self-reported)	2.3	3.0	4.3	1.3	2.1
Schizophrenia vs Biploar Disorder	2.2	2.9	4.1	1.3	2.0
Angina	2.2	2.9	4.1	1.3	2.0
Heart attack/myocardial infarction (self-reported)	2.2	2.8	4.0	2.0	1.2
High cholesterol (Self-reported)	2.1	3.8	5.8	-2.4	-1.3
Arm fat-free mass (left)	2.1	10.9	15.2	2.6	3.9
Vascular/heart problems diagnosed by doctor	2.1	5.6	6.7	-2.1	-2.6
Supplements: Zinc	2.0	2.2	3.1	1.8	1.1
Medication: Atenolol	2.0	2.6	3.1	1.4	1.8
Arm predicted mass (right)	2.0	10.5	13.8	2.7	3.7
Heart attack	1.9	2.4	3.7	1.9	1.1
Diabetes (self-reported)	1.9	3.0	3.3	1.6	1.8
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	4.2	-2.0	-1.5
Chronic bronchitis/emphysema (mother)	1.9	2.2	2.3	-1.4	-1.5
Arm fat-free mass (right)	1.9	9.9	13.5	2.5	3.7
Comparative body size at age 10	1.9	5.2	8.9	1.2	3.0
Eye problems/disorders: Cataract	1.9	2.2	3.0	1.2	1.7
Rheumatoid Arthritis	1.8	2.5	4.6	2.1	0.7
Number of treatments/medications taken	1.8	3.2	4.6	2.1	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	3.6	1.4	1.9
Leg fat percentage (right)	1.8	6.6	10.1	1.8	3.2
Suffer from ‘nerves’	1.8	2.8	5.6	0.2	2.4
Diabetes diagnosed by doctor	1.8	2.9	3.7	1.4	1.9
Impedance of whole body	1.8	9.1	12.7	-2.4	-3.6
LDL Cholesterol	1.6	2.5	4.9	-2.2	0.1
Medication: Metformin	1.6	2.2	2.6	1.4	1.6
High blood pressure	1.6	4.6	5.9	1.8	2.4
Illnesses of siblings	1.6	2.2	4.4	2.1	0.0
Average weekly red wine intake	1.6	2.4	4.0	-2.0	-0.8
Medication: Atorvastatin	1.6	2.0	2.0	-1.4	-1.4
Irritability	1.6	2.8	5.4	2.3	0.3
Worry (Nagel 2018)	1.5	3.2	5.1	1.1	2.3
Neuroticism (2016)	1.5	2.2	2.3	1.5	1.4
Current tobacco smoking	1.5	2.4	3.9	0.9	-2.0
High blood pressure (mother)	1.5	2.1	3.3	-0.9	-1.8
Breast cancer (self-reported)	1.5	1.8	3.5	0.3	1.9
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.3	-1.8	-0.7
Body Mass Index (BMI) (2010)	1.4	1.9	3.2	0.7	1.8
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	2.0	1.4	1.3
Trunk fat-free mass	1.4	8.1	11.1	2.3	3.3
Trunk predicted mass	1.4	8.0	10.9	2.3	3.3
Birth weight	1.4	2.9	3.7	1.5	1.9
Exposure to tobacco smoke outside home	1.4	1.9	3.4	1.8	0.6
Pulse rate, automated reading	1.4	4.4	4.5	2.1	2.1
Hypertension (Self-reported)	1.4	3.8	4.7	1.7	2.2
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.2	-0.3	1.8
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.4	-1.8	0.0
Falls in the last year	1.3	1.8	2.1	-1.4	1.2
Number of live births	1.3	1.8	3.7	-1.9	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	4.6	-1.9	-2.1
Blood clot in the leg (DVT)	1.3	1.7	3.0	-1.7	-0.6
Mean time to correctly identify matches	1.3	2.5	3.6	1.1	1.9
Mineral and other dietary supplements	1.3	1.8	3.1	-0.7	-1.8
Smoking status: Current	1.3	2.1	3.6	0.8	-1.9
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.0	-1.7	-0.4
Reaction Time	1.2	2.3	2.6	1.6	1.4
Waist Hip Ratio (WHR)	1.2	5.2	7.7	-1.7	-2.8
Lung FVC	1.2	6.1	6.8	-2.3	-2.6
Heart disease (mother)	1.2	1.4	1.8	-1.0	-1.4
Mood swings	1.2	2.1	4.2	2.0	-0.3
Illnesses of father: High blood pressure	1.2	1.5	1.6	-1.2	-1.2
Intelligence (Savage-Jansen 2018)	1.1	3.3	5.0	-2.2	-1.3
Alzheimer’s Disease (including proxy)	1.1	1.6	2.8	1.7	0.7
Breast Cancer	1.1	2.6	5.1	2.3	0.0
Medication: Co-codamol	1.1	1.2	1.6	-1.3	-0.9
Alcohol usually taken with meals	1.1	1.8	2.2	-1.5	-1.2
Fluid intelligence score	1.1	2.2	2.3	-1.5	-1.5
Noisy workplace	1.1	1.3	2.2	0.7	-1.5
Glaucoma (self-reported)	1.1	1.3	2.4	-1.6	-0.5
Worry too long after embarrassment	1.1	1.8	2.1	1.2	1.5
Qualifications: College or University degree	1.1	3.6	4.0	-2.0	-1.8
Osteoarthritis (self-reported)	1.1	1.4	1.8	1.0	1.4
Pack years of smoking	1.1	1.5	2.1	1.0	1.4
Prostate Cancer	1.0	1.4	2.8	-1.7	-0.2
Age at First Birth	1.0	1.5	3.0	0.1	-1.7
Taking other prescription medications	1.0	1.5	2.5	1.6	0.7
Age when periods started (menarche)	1.0	2.5	2.7	-1.5	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.8	1.7	0.6
Forced vital capacity (FVC), Best measure	1.0	3.7	4.7	-1.7	-2.2
Eye problems/disorders: None of the above	1.0	1.1	1.6	-0.8	-1.3
Illnesses of siblings: Diabetes	1.0	1.2	2.3	-1.5	-0.1
Ever had bowel cancer screening	1.0	1.2	2.3	-1.5	0.2
Osteoporosis (self-reported)	1.0	1.2	1.3	1.1	1.1
Diastolic blood pressure, automated reading	1.0	3.2	6.5	0.1	2.5
Major Depression (MDD)	0.9	1.1	2.2	1.5	0.2
Primary Biliary Cirrhosis	0.9	1.2	2.1	1.4	0.6
Average weekly fortified wine intake	0.9	1.1	2.2	-1.5	0.1
Forced vital capacity (FVC)	0.9	3.4	3.9	-1.7	-2.0
Qualifications: None of the above	0.9	2.0	2.3	1.5	1.2
Medication: Simvastatin	0.9	1.3	2.3	0.5	1.5
Impedance of arm (right)	0.9	4.3	5.6	-1.7	-2.4
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.9	1.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	3.7	-1.9	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.3	-1.5	0.1
Birth weight of first child	0.9	1.7	3.4	0.1	1.9
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	-1.5	-0.3
Number of full brothers	0.9	1.2	2.2	-1.5	-0.3
Back pain experienced in last month	0.9	1.3	2.2	-1.5	-0.6
Medication: Blood pressure	0.9	1.6	1.7	1.3	1.3
Medication for hormone replacement therapy	0.8	0.9	1.5	-0.6	-1.2
Pulse rate	0.8	1.3	2.4	0.5	1.6
Impedance of arm (left)	0.8	3.8	5.4	-1.5	-2.3
Number of children fathered	0.8	0.9	1.6	1.3	-0.3
Supplements: Vitamin C	0.8	1.0	1.9	0.2	-1.4
Miserableness	0.8	1.3	2.2	1.5	-0.7
Heart disease (siblings)	0.8	1.0	1.0	-1.0	1.0
Bipolar Disorder or Schizophrenia	0.7	1.6	2.5	-1.6	-0.8
Ovarian Cancer	0.7	1.0	1.2	0.8	-1.1
Smoking Status	0.7	1.6	3.2	0.1	-1.8
Respiratory disease	0.7	1.6	3.0	-0.4	-1.7
Ever had hysterectomy (womb removed)	0.7	0.7	1.1	-0.6	1.0
Hair/balding pattern: Pattern 2	0.7	0.9	1.5	0.6	1.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	0.9	0.8	-1.0
Qualifications: A levels/AS levels or equivalent	0.7	1.4	1.8	-1.4	-1.0
Asthma	0.7	1.5	2.9	-0.3	-1.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.6	0.5	-1.3
Mouth/teeth dental problems: Loose teeth	0.7	0.8	0.9	0.9	-0.9
Medication for pain relief, constipation, heartburn	0.7	1.2	2.0	-0.7	-1.4
Medication: Seretide 50 evohaler	0.7	0.9	1.2	1.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.1	-0.8	-1.1
Family relationship satisfaction	0.7	0.8	1.7	0.0	-1.3
Leg pain on walking	0.7	0.9	1.2	-1.1	-0.8
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.0	-1.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.7	1.6	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.1	0.8	-1.1
Asthma (self-reported)	0.7	1.3	2.6	-0.2	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.9	-1.7	-0.4
Mother’s age at death	0.7	0.8	1.0	-0.8	-1.0
Basal cell carcinoma (self-reported)	0.7	0.8	1.6	-0.1	1.3
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.3	-1.5	-0.7
Chronotype (morning person)	0.6	1.4	1.7	1.1	1.3
Hearing difficulty/problems: Yes	0.6	0.9	1.5	-1.2	-0.5
Vitamin and mineral supplements	0.6	0.9	1.5	-1.2	-0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.0	0.7	1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	0.9	-0.6	-1.0
Sitting height	0.6	4.3	6.1	1.6	2.5
Financial difficulties in last 2 years	0.6	0.8	1.6	1.3	0.2
Pain all over the body in last month	0.6	0.6	0.7	-0.8	-0.8
Depression (self-reported)	0.6	0.7	1.3	-0.2	1.1
Headache pain in last month	0.6	1.0	1.1	-0.9	-1.1
Age at first live birth	0.6	1.0	1.5	-0.8	-1.2
Medication: Ibuprofen	0.6	0.7	1.4	-1.2	-0.1
Overall health rating	0.6	1.4	2.1	1.4	0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.5	-1.2	0.2
Qualifications: nursing, teaching	0.6	0.9	1.7	-0.2	-1.3
Medication for cholesterol	0.6	0.8	1.5	-1.2	-0.5
Illnesses of father: None of the above (group 1)	0.6	0.7	0.9	0.9	0.8
Supplements: Fish oil (including cod liver oil)	0.6	0.7	0.8	-0.8	0.9
Ulcerative Colitis (UC)	0.5	0.9	1.1	1.1	0.9
Ulcerative Colitis	0.5	0.7	0.9	0.9	0.8
Blood Eosinophil Count	0.5	3.7	4.0	2.0	1.9
Heel T-Score	0.5	3.8	6.5	1.1	2.5
Lung FEV1/FVC ratio	0.5	2.5	3.6	-1.9	1.2
Pack years adult smoking proportion	0.5	0.7	0.8	0.9	0.8
Happiness	0.5	0.6	0.8	0.9	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.9	0.9	-0.3
Eye problems/disorders: Glaucoma	0.5	0.6	0.7	-0.8	-0.7
Average weekly beer plus cider intake	0.5	0.7	1.0	0.6	-1.0
Fractured/broken bones in last 5 years	0.5	0.6	1.1	-1.1	-0.2
Supplements: Calcium	0.5	0.5	1.1	-1.0	0.0
Blood Platelet Count	0.4	4.2	5.2	2.3	1.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.0	0.7	1.0
Hearing difficulty/problems with background noise	0.4	0.7	1.2	-1.1	0.3
Hair/balding pattern: Pattern 4	0.4	0.9	1.3	0.7	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.9	-0.9	0.2
Age at last live birth	0.4	0.6	0.9	-0.9	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	0.1	-1.0
Illnesses of father: Heart disease	0.4	0.6	0.9	-0.9	-0.6
Medication: Gliclazide	0.4	0.5	0.5	0.7	0.7
Depression (Nagel 2018)	0.3	0.4	0.4	-0.6	-0.7
Alzheimer’s Disease (in mother)	0.3	0.4	0.5	0.7	0.6
Hypothyroidism (self reported)	0.3	0.7	1.0	0.7	-1.0
Hand grip strength (left)	0.3	0.7	1.1	0.5	-1.1
Average weekly spirits intake	0.3	0.3	0.4	0.6	0.6
Systolic blood pressure, automated reading	0.3	1.0	1.9	0.3	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	1.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	0.8	0.4
Had other major operations	0.3	0.4	0.7	-0.8	-0.3
Mouth/teeth dental problems	0.3	0.5	0.8	-0.9	0.4
Pulse wave reflection index	0.3	0.4	0.6	-0.8	-0.3
Loud music exposure frequency	0.3	0.3	0.3	-0.6	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.0	1.0	-0.2
High blood pressure (siblings)	0.3	0.4	0.6	-0.8	-0.4
Pulse wave peak to peak time	0.3	0.4	0.6	0.8	0.3
Average weekly champagne plus white wine intake	0.3	0.4	0.7	-0.4	0.8
Financial situation satisfaction	0.3	0.4	0.8	0.1	-0.9
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.3	-0.6	-0.6
Medication: Paracetamol	0.3	0.5	0.7	0.6	0.8
Ever smoked	0.3	0.4	0.7	0.5	-0.8
Number of operations (self-reported)	0.3	0.4	0.8	-0.2	0.9
Cholesterol lowering medication	0.3	0.4	0.7	-0.2	-0.8
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.2	-0.6
Crohns Disease (2012)	0.2	0.4	0.7	-0.2	-0.8
Fasting Glucose	0.2	0.3	0.4	0.5	-0.6
HbA1C	0.2	0.3	0.5	0.2	-0.7
Schizophrenia (2014)	0.2	0.5	0.9	-0.9	-0.2
Diabetes (father)	0.2	0.3	0.5	-0.7	-0.2
Maternal smoking around birth	0.2	0.3	0.6	0.1	-0.8
Serious illness, injury or assault to yourself	0.2	0.2	0.3	0.6	0.3
Supplements: Glucosamine	0.2	0.2	0.3	0.3	0.6
Medication: Levothyroxine sodium	0.2	0.4	0.6	0.8	-0.4
Had menopause	0.2	0.3	0.4	-0.4	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	-0.1	0.9
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.7	0.4
Lung cancer (father)	0.2	0.2	0.4	0.6	0.1
Pulse wave Arterial Stiffness index	0.2	0.3	0.4	-0.6	-0.3
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.4	0.5
Alcohol intake frequency.	0.2	0.6	1.0	0.4	1.0
Had major operations	0.2	0.2	0.3	-0.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.7	0.2
Friendships satisfaction	0.2	0.2	0.3	-0.6	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.7	-0.4
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.3	-0.6
Hearing aid user	0.2	0.2	0.2	-0.5	0.4
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.6	0.0
Age started oral contraceptive pill	0.2	0.3	0.6	0.7	-0.1
Schizophrenia (2018)	0.1	0.3	0.3	-0.5	0.5
Crohns Disease (2017)	0.1	0.3	0.5	-0.3	-0.7
Irritable Bowel Disease (IBD)	0.1	0.4	0.7	0.8	0.2
Coronary Artery Disease (CAD)	0.1	0.2	0.3	0.2	0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.4	0.2
Blood Red Count	0.1	0.5	0.9	-1.0	-0.2
Height	0.1	2.7	5.2	0.4	2.3
Cardiovascular Disease	0.1	0.2	0.2	-0.4	0.5
Hair Pigment	0.1	4.1	4.7	-1.9	-2.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	0.5	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.1	0.5
Diabetes (mother)	0.1	0.1	0.2	-0.1	-0.5
Severe depression (siblings)	0.1	0.2	0.3	0.6	-0.1
Hand grip strength (right)	0.1	0.4	0.5	-0.7	-0.5
Townsend deprivation index at recruitment	0.1	0.1	0.1	-0.4	-0.1
Number of incorrect matches in round	0.1	0.2	0.2	-0.4	-0.4
Past tobacco smoking	0.1	0.1	0.2	-0.0	0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	-0.3	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	0.4	0.2
Medication: Lansoprazole	0.1	0.1	0.2	-0.2	-0.4
Prospective memory result	0.1	0.1	0.3	-0.1	-0.5
Standing height	0.1	1.4	1.9	1.0	1.4
Breastfed as a baby	0.1	0.1	0.2	0.1	-0.4
Peak expiratory flow (PEF)	0.1	0.2	0.3	0.5	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.3	0.5
Medication: Paracetamol	0.1	0.2	0.4	0.6	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.1	-0.6
Health satisfaction	0.1	0.2	0.4	0.6	-0.1
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.4	0.1
Migraine (self-reported)	0.1	0.2	0.3	-0.2	0.6
Smoking status: Previous	0.1	0.1	0.1	0.4	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.2	0.4	0.4
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.5	-0.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	-0.6	0.4
Medication: Lisinopril	0.1	0.1	0.1	-0.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	-0.3	0.3
Triglycerides	0.0	0.1	0.1	-0.4	0.1
Systolic Blood Pressure	0.0	0.1	0.2	0.4	-0.3
Tanning	0.0	0.4	0.5	0.7	0.5
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.1	-0.0
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.2	-0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.2	-0.3
Alcohol intake versus 10 years previously	0.0	0.0	0.1	0.0	0.3
Worrier / anxious feelings	0.0	0.0	0.0	0.2	0.0
Tense / ‘highly strung’	0.0	0.0	0.0	0.2	-0.2
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	0.1	0.1
Shortness of breath walking on level ground	0.0	0.0	0.0	0.1	-0.1
Medication: Omeprazole	0.0	0.0	0.0	-0.1	0.0
Comparative height size at age 10	0.0	0.2	0.4	0.2	0.6
Knee pain experienced in last month	0.0	0.1	0.1	-0.3	-0.2
Alcohol drinker status: Never	0.0	0.0	0.1	-0.0	0.2
Unable to work because of sickness or disability	0.0	0.1	0.1	0.3	0.1
Myopia	0.0	0.0	0.0	0.2	0.2
Alcohol drinker status: Previous	0.0	0.1	0.1	0.1	0.3

Hub : Genes

NR1I2

Models

Trait associations