TWAS hub - NR3C1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.163	0.064	0.00790	0.001	NA	0.011	NA	0.031	2.8e-01	NA	7.8e-02	NA	7.3e-03
2	GTEx	Esophagus Mucosa	0.160	0.052	0.00083	0.105	NA	0.072	NA	0.092	1.8e-07	NA	1.4e-05	NA	1.1e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Trunk fat-free mass	4.6	26.6	53.1	-7.3	-0.4
Trunk predicted mass	4.5	26.0	51.8	-7.2	-0.4
Breast cancer (self-reported)	4.5	5.4	9.6	1.1	3.1
Basal metabolic rate	4.4	24.2	46.9	-6.8	-1.2
Whole body fat-free mass	4.3	24.6	47.9	-6.9	-1.1
Leg fat-free mass (left)	4.1	21.9	40.8	-6.4	-1.8
Leg predicted mass (left)	4.1	21.6	40.4	-6.4	-1.7
Whole body water mass	4.1	23.4	45.8	-6.8	-1.0
Weight	4.0	19.7	35.6	-6.0	-2.0
Leg fat-free mass (right)	4.0	21.5	39.2	-6.3	-1.9
Leg predicted mass (right)	4.0	21.3	38.8	-6.2	-1.9
Mean Putamen Volume	3.9	4.5	8.9	-3.0	0.2
Hypothyroidism (self reported)	3.9	8.9	13.6	-3.7	2.0
Trunk fat mass	3.9	16.5	25.2	-5.0	-2.8
Hip circumference	3.9	16.7	28.5	-5.3	-2.2
Eye problems/disorders: Cataract	3.9	4.6	8.2	-2.9	1.0
Age at last live birth	3.7	5.4	8.5	-1.5	2.9
Arm fat-free mass (left)	3.7	18.8	37.3	-6.1	-0.6
Whole body fat mass	3.6	15.0	22.4	-4.7	-2.8
Comparative height size at age 10	3.6	19.8	39.4	-6.3	-0.4
Arm predicted mass (left)	3.6	18.4	36.0	-6.0	-0.9
Arm fat-free mass (right)	3.5	18.1	35.3	-5.9	-1.0
Lung FVC	3.4	17.2	29.6	5.4	-2.2
Pulse wave reflection index	3.4	4.2	8.3	2.9	-0.2
Waist circumference	3.3	11.9	20.0	-4.5	-2.0
Hypothyroidism/myxoedema (self-reported)	3.3	6.5	10.3	-3.2	1.7
Arm predicted mass (right)	3.3	16.9	32.7	-5.7	-1.0
Age started oral contraceptive pill	3.3	4.1	5.9	1.5	-2.4
Pulse rate, automated reading	3.1	10.2	19.7	-0.8	4.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.6	5.8	-2.4	1.2
Medication: Levothyroxine sodium	3.0	5.0	9.2	-3.0	0.9
Leg fat mass (right)	3.0	11.5	18.1	-4.2	-2.2
Ulcerative Colitis (UC)	2.9	5.4	10.2	3.2	0.8
Arm fat mass (right)	2.9	12.1	19.1	-4.4	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.4	8.8	-3.0	0.1
Arm fat mass (left)	2.9	12.0	18.7	-4.3	-2.3
Leg fat mass (left)	2.9	11.3	16.5	-4.1	-2.5
Height	2.8	54.5	106.5	-10.3	1.6
Hand grip strength (right)	2.8	7.7	7.8	-2.8	-2.7
Hayfever, allergic rhinitis or eczema	2.8	6.1	6.7	-2.3	2.6
Standing height	2.8	27.7	55.1	-7.4	0.5
Allergy	2.7	6.3	8.6	2.0	-2.9
Chronic bronchitis/emphysema (mother)	2.7	3.2	5.6	2.4	-0.9
Asthma (self-reported)	2.7	5.4	6.7	-2.0	2.6
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	5.3	0.9	-2.3
Wears glasses or contact lenses	2.6	2.9	4.2	-1.3	-2.1
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	5.3	2.3	1.1
Major Depression (MDD)	2.4	2.9	3.2	-1.8	-1.6
Coronary Artery Disease (CAD)	2.4	2.9	3.6	1.4	-1.9
BMI	2.4	14.2	22.7	-4.8	-2.4
Supplements: Zinc	2.4	2.6	5.1	-2.3	-0.5
Mood swings	2.4	4.3	8.4	-2.9	0.5
Breast Cancer	2.3	5.5	5.6	-2.4	2.3
Wheeze or whistling in the chest in last year	2.3	4.1	6.5	-2.5	1.4
Hypertension (Self-reported)	2.3	6.3	12.5	-0.3	-3.5
Commuting to job workplace: Walk	2.3	2.4	2.5	-1.6	-1.6
Body Mass Index (BMI) (2010)	2.2	3.0	5.9	-2.4	-0.1
Crohns Disease (2012)	2.2	3.5	5.9	1.1	-2.4
HDL Cholesterol	2.2	3.7	4.1	2.0	-1.8
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	4.5	2.1	0.5
High blood pressure	2.2	6.1	12.2	-0.3	-3.5
Asthma	2.2	4.4	6.3	-1.6	2.5
Illnesses of siblings: Diabetes	2.2	2.7	4.7	-0.8	-2.2
Schizophrenia (2018)	2.1	4.4	7.8	-1.0	2.8
Alzheimer’s Disease (in father)	2.1	2.2	3.9	-0.8	2.0
Trunk fat percentage	2.1	8.5	9.7	-3.1	-2.7
Father’s age at death	2.1	2.9	5.7	-0.2	2.4
Length of working week for main job	2.1	2.4	3.9	-0.9	-2.0
Vascular/heart problems diagnosed by doctor	2.1	5.8	11.7	0.1	3.4
Relative age of first facial hair	2.0	4.2	8.0	-2.8	0.6
Townsend deprivation index at recruitment	2.0	2.8	5.5	-2.3	-0.4
Had menopause	2.0	2.5	3.6	1.2	-1.9
Pulse wave peak to peak time	2.0	2.4	4.7	-2.2	0.3
Medication: Omeprazole	2.0	2.4	4.8	-0.1	-2.2
Depressed Affect (Nagel 2018)	1.9	3.9	7.4	-2.7	-0.6
Medication for hormone replacement therapy	1.9	2.1	2.2	1.5	-1.4
Financial difficulties in last 2 years	1.9	2.6	5.2	-2.3	-0.1
Birth weight of first child	1.9	3.4	6.5	-2.5	-0.7
Angina (self-reported)	1.9	2.5	3.1	1.4	-1.8
Family relationship satisfaction	1.9	2.3	4.4	0.4	-2.1
Allergy or Eczema	1.8	4.9	5.0	-2.2	2.2
Respiratory disease	1.8	4.0	7.2	-0.9	2.7
Hair/balding pattern: Pattern 2	1.8	2.2	4.3	0.4	2.1
Body fat percentage	1.8	7.3	7.8	-2.8	-2.6
Miserableness	1.8	3.1	6.2	-2.5	-0.2
Myopia	1.8	2.6	5.3	-2.3	-0.1
HbA1C	1.7	1.9	3.7	-1.9	0.3
Current tobacco smoking	1.7	2.7	5.2	2.3	-0.5
Body mass index (BMI)	1.7	7.4	8.7	-3.0	-2.5
Exposure to tobacco smoke outside home	1.7	2.3	4.6	-0.1	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	6.9	-2.6	0.4
Ever had prostate specific antigen (PSA) test	1.7	2.0	4.0	-2.0	-0.1
Lupus	1.6	2.5	5.0	-2.2	0.1
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	3.5	0.1	-1.9
Arm fat percentage (right)	1.6	6.3	8.1	-2.8	-2.1
Medication: Ventolin 100micrograms inhaler	1.6	2.1	4.1	-2.0	0.4
Comparative body size at age 10	1.6	4.5	7.3	-1.3	-2.7
Number of full brothers	1.6	2.0	3.2	-1.8	-0.9
Mouth/teeth dental problems: Loose teeth	1.6	1.8	3.3	1.8	0.6
Smoking status: Current	1.6	2.5	4.5	2.1	-0.7
Blood Eosinophil Count	1.5	11.9	15.9	-2.8	4.0
Angina	1.5	2.0	2.9	1.1	-1.7
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	3.5	1.9	-0.0
Birth weight	1.5	3.4	6.7	-2.6	0.0
Leg fat percentage (right)	1.5	5.3	7.6	-2.8	-1.8
Arm fat percentage (left)	1.5	6.1	6.3	-2.5	-2.4
Leg fat percentage (left)	1.5	5.5	6.2	-2.5	-2.2
Basal cell carcinoma (self-reported)	1.5	1.8	3.6	1.9	0.1
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.1	1.8	-0.6
Heart attack	1.4	1.7	2.3	1.5	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	3.5	-0.2	1.9
Medication: Amlodipine	1.4	2.0	2.7	1.6	-1.1
Osteoporosis (self-reported)	1.4	1.7	3.1	1.8	-0.5
Alcohol drinker status: Never	1.4	1.7	2.3	1.5	-1.0
Ulcerative Colitis	1.3	1.9	3.6	1.9	-0.4
Pain all over the body in last month	1.3	1.4	1.7	-1.0	1.3
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.3	-1.8	0.4
Pulse wave Arterial Stiffness index	1.3	1.6	3.1	1.8	-0.0
Number of children fathered	1.3	1.5	1.9	-1.0	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.9	-0.2	-1.7
Heart attack/myocardial infarction (self-reported)	1.3	1.7	2.5	1.6	-1.0
Irritable Bowel Disease (IBD)	1.2	2.9	5.7	2.4	0.4
Ovarian Cancer	1.2	1.5	2.9	1.7	-0.4
LDL Cholesterol	1.2	1.9	2.8	-1.7	-0.9
Hand grip strength (left)	1.2	3.2	4.9	-2.2	-1.2
Average weekly spirits intake	1.2	1.5	2.8	-0.4	-1.7
Systolic blood pressure, automated reading	1.2	3.6	7.2	-0.1	-2.7
Diabetes (father)	1.2	1.4	2.7	-1.6	0.4
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.8	1.7	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.2	1.5	-0.7
Knee pain experienced in last month	1.2	1.8	3.2	0.6	-1.8
Friendships satisfaction	1.2	1.5	2.5	1.6	-0.8
Ever taken oral contraceptive pill	1.2	1.3	2.3	1.5	-0.6
Alzheimer’s Disease (in mother)	1.1	1.3	2.7	1.6	-0.1
Lung FEV1/FVC ratio	1.1	5.8	7.8	-2.8	1.9
Impedance of leg (right)	1.1	5.3	6.4	2.1	2.5
Multivitamins +/- minerals	1.1	1.3	1.4	-1.1	1.2
Number of live births	1.1	1.6	3.1	0.3	1.8
Happiness	1.1	1.3	2.5	1.6	-0.4
Illnesses of mother	1.1	1.3	2.2	-1.5	0.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.5	-0.3	-1.6
Heart disease (siblings)	1.1	1.3	1.5	-1.2	-1.1
Pack years of smoking	1.1	1.6	2.4	0.9	-1.6
Cardiovascular Disease	1.0	3.3	6.3	-0.6	-2.5
Medication: Atenolol	1.0	1.3	2.3	0.6	-1.5
Impedance of leg (left)	1.0	4.6	5.6	2.4	1.9
Mouth/teeth dental problems	1.0	1.5	1.7	-1.3	1.1
Alcohol intake versus 10 years previously	1.0	1.5	2.2	-0.9	-1.5
Prospective memory result	1.0	1.2	2.3	1.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.2	2.1	-0.2
Mother’s age at death	1.0	1.2	2.3	-1.5	0.3
Diabetes (self-reported)	0.9	1.4	1.4	-1.1	-1.2
Tense / ‘highly strung’	0.9	1.6	2.9	0.5	1.7
Peak expiratory flow (PEF)	0.9	2.1	3.9	2.0	-0.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.9	-0.0	1.7
High cholesterol (Self-reported)	0.9	1.6	3.1	0.3	-1.8
Alzheimer’s Disease (including proxy)	0.8	1.1	1.9	0.6	1.4
Systolic Blood Pressure	0.8	4.1	8.2	0.2	-2.9
Neuroticism	0.8	1.8	1.8	-1.4	1.3
Fed-up feelings	0.8	1.5	2.6	-1.6	0.7
Breastfed as a baby	0.8	0.9	1.2	1.1	0.8
Medication: Blood pressure	0.8	1.4	2.7	-0.2	-1.7
Overall health rating	0.8	1.7	2.2	-1.5	1.1
Had major operations	0.8	1.0	1.4	-1.2	-0.7
Ever had bowel cancer screening	0.8	0.9	1.4	-0.6	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.7	1.3	-0.0
Osteoarthritis (self-reported)	0.8	1.0	2.0	0.1	-1.4
Medication: Gliclazide	0.8	0.9	1.6	-1.3	-0.5
Ever depressed for a whole week	0.8	0.9	1.9	0.0	-1.4
Bipolar Disorder or Schizophrenia	0.7	1.7	2.0	-1.2	1.4
Prostate Cancer	0.7	1.0	1.5	1.2	0.7
Age at First Birth	0.7	1.0	1.2	1.1	-0.9
Bipolar Disorder (2011)	0.7	0.7	1.4	-0.2	1.2
Schizophrenia (2014)	0.7	1.6	2.9	-0.5	1.7
Vitamin and mineral supplements	0.7	1.0	2.0	0.1	-1.4
Pack years adult smoking proportion	0.7	1.1	1.2	1.0	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.3	-0.9	-1.5
Serious illness, injury or assault to yourself	0.7	0.8	0.9	0.9	0.8
Number of incorrect matches in round	0.7	1.2	2.0	-1.4	-0.7
Qualifications: None of the above	0.7	1.4	2.2	-1.5	0.8
Medication: Ramipril	0.7	1.0	1.6	1.2	0.6
Illnesses of siblings	0.7	0.9	1.8	-0.3	1.3
Neuroticism score	0.7	1.4	1.7	-1.3	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.1	-1.0	1.1
Pulse rate	0.7	1.1	1.7	-1.3	0.7
Mouth/teeth dental problems: Dentures	0.7	1.2	1.8	0.8	-1.4
Medication: Cholesterol lowering	0.7	1.1	1.8	-0.7	-1.3
Depression (self-reported)	0.7	0.8	1.6	-1.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.4	-1.2	-0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.6	1.3	0.2
Average weekly red wine intake	0.7	1.0	2.1	-1.4	0.0
Mineral and other dietary supplements	0.7	1.0	1.2	-0.9	-1.1
Guilty feelings	0.7	1.1	1.5	-1.2	0.8
Hearing aid user	0.7	0.8	0.8	-0.8	0.9
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.2	-0.7	-1.1
Supplements: Calcium	0.7	0.8	0.9	1.0	0.8
Impedance of whole body	0.7	3.7	6.4	2.5	1.0
Intelligence (Savage-Jansen 2018)	0.6	2.0	2.3	-1.5	-1.3
Neuroticism (Nagel 2018)	0.6	1.4	2.3	-1.5	0.7
Primary Biliary Cirrhosis	0.6	0.8	1.6	-0.3	-1.3
Heel T-Score	0.6	4.9	9.7	0.1	-3.1
Medication: Co-codamol	0.6	0.7	1.4	0.1	-1.2
Qualifications: CSEs or equivalent	0.6	0.8	1.4	0.3	1.2
Stomach or abdominal pain in last month	0.6	0.8	1.2	0.6	1.1
Fluid intelligence score	0.6	1.3	2.6	-0.2	-1.6
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.5	1.2	0.7
Headache pain in last month	0.6	1.1	1.7	-1.3	0.7
Worry too long after embarrassment	0.6	1.0	1.6	0.6	1.3
Heart disease (mother)	0.6	0.8	0.8	0.9	0.9
Loneliness, isolation	0.6	0.8	1.0	0.8	-1.0
Number of self-reported non-cancer illnesses	0.6	1.0	1.8	-1.4	-0.3
Medication: Blood pressure	0.6	1.2	2.0	0.6	-1.4
Alcohol drinker status: Previous	0.6	0.6	1.2	1.1	-0.3
Bipolar Disorder (2018)	0.5	0.7	1.1	-0.6	-1.0
Worry (Nagel 2018)	0.5	1.0	2.0	0.2	1.4
Taking other prescription medications	0.5	0.7	1.4	-0.3	1.2
Sitting height	0.5	3.7	4.4	-2.1	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	0.9	-1.0	-0.9
Time employed in main current job	0.5	0.5	0.9	0.5	-0.9
Falls in the last year	0.5	0.6	1.1	-1.0	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.6	-0.7	0.8
Gout (self-reported)	0.5	0.7	1.0	0.7	-1.0
Health satisfaction	0.5	0.6	0.8	0.7	-0.9
Medication: Aspirin	0.5	0.6	0.8	-0.6	-0.9
Supplements: Vitamin C	0.5	0.6	0.8	-0.7	0.9
Illnesses of father: Heart disease	0.5	0.7	1.1	0.5	-1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	-0.9	0.6
Medication for cholesterol	0.5	0.8	1.5	-0.4	1.2
Medication: Aspirin	0.5	0.7	0.7	-0.8	-0.8
Average weekly champagne plus white wine intake	0.5	0.6	1.0	-1.0	0.5
Illnesses of father: High blood pressure	0.5	0.7	1.3	-0.2	-1.1
Average weekly beer plus cider intake	0.5	0.7	1.4	-0.1	-1.2
Fractured/broken bones in last 5 years	0.5	0.7	0.7	0.8	0.8
Blood Red Count	0.4	3.5	4.2	1.6	2.1
Smoking Status	0.4	0.8	1.6	1.3	0.3
Chronotype (morning person)	0.4	0.8	1.4	-1.2	-0.5
Severe depression (siblings)	0.4	0.5	0.7	-0.8	0.5
Average weekly fortified wine intake	0.4	0.4	0.7	-0.8	0.3
Relative age voice broke	0.4	0.7	1.2	-1.1	0.5
Nervous feelings	0.4	0.7	1.3	-0.3	1.1
Hearing difficulty/problems with background noise	0.4	0.7	1.3	-0.4	1.1
Had other major operations	0.4	0.5	0.7	-0.5	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.2	-1.1	-0.8
Hair/balding pattern: Pattern 3	0.4	0.7	0.7	0.8	-0.8
Medication: Lansoprazole	0.4	0.5	0.9	0.9	-0.3
Impedance of arm (left)	0.4	1.7	3.2	1.8	0.4
Medication: Ibuprofen	0.4	0.5	0.9	-0.2	1.0
Medication: Allopurinol	0.4	0.5	0.5	0.7	-0.7
Diabetes diagnosed by doctor	0.4	0.7	0.7	-0.9	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	0.8	0.9	0.6
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.4	-0.6	-0.6
Commuting to job workplace: Public transport	0.4	0.4	0.9	0.2	-0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	0.0	1.0
Depression (Nagel 2018)	0.3	0.5	0.7	-0.8	0.5
Neuroticism (2016)	0.3	0.4	0.6	0.4	0.8
Triglycerides	0.3	0.5	0.7	-0.8	-0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.7	-0.7	-0.8
Ever had hysterectomy (womb removed)	0.3	0.4	0.5	0.5	-0.7
Medication: Metformin	0.3	0.4	0.5	-0.7	-0.5
Supplements: Glucosamine	0.3	0.4	0.7	0.9	-0.1
High blood pressure (mother)	0.3	0.5	0.9	0.2	0.9
Alcohol usually taken with meals	0.3	0.4	0.8	0.3	0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	0.1	-0.8
Medication: Simvastatin	0.3	0.4	0.5	0.6	-0.7
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	0.2	-0.8
Loud music exposure frequency	0.3	0.4	0.7	-0.8	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.8	0.9	-0.2
Shortness of breath walking on level ground	0.3	0.4	0.6	0.8	-0.2
Qualifications: College or University degree	0.3	0.9	1.8	-0.2	-1.4
Emphysema/chronic bronchitis	0.3	0.4	0.7	0.8	0.3
Medication: Seretide 50 evohaler	0.3	0.4	0.7	-0.9	-0.1
Mean time to correctly identify matches	0.3	0.5	1.0	-1.0	0.2
Number of full sisters	0.3	0.4	0.7	-0.4	0.8
Qualifications: nursing, teaching	0.3	0.4	0.6	-0.8	-0.5
Financial situation satisfaction	0.3	0.3	0.6	-0.2	-0.8
Medication: Atorvastatin	0.3	0.3	0.3	0.6	-0.5
Irritability	0.3	0.6	1.0	0.3	1.0
Risk taking	0.3	0.5	0.8	0.9	0.4
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	0.5	0.4
Reaction Time	0.2	0.4	0.5	-0.6	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	-0.2	-0.8
Sensitivity / hurt feelings	0.2	0.4	0.7	-0.4	0.8
Hearing difficulty/problems: Yes	0.2	0.2	0.5	-0.0	0.7
Diabetes (mother)	0.2	0.2	0.3	0.6	0.3
Maternal smoking around birth	0.2	0.3	0.6	-0.2	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.2	-0.5	-0.5
Age when periods started (menarche)	0.2	0.4	0.8	0.9	0.0
Chronic bronchitis/emphysema (father)	0.2	0.2	0.2	-0.5	0.3
Past tobacco smoking	0.2	0.4	0.7	-0.8	-0.2
Forced vital capacity (FVC)	0.2	0.7	1.1	1.1	-0.5
Impedance of arm (right)	0.2	1.0	1.2	1.1	0.8
Worrier / anxious feelings	0.2	0.4	0.5	0.4	0.7
Lung cancer (father)	0.2	0.2	0.4	0.6	-0.1
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.2	-0.5
Medication: Paracetamol	0.2	0.3	0.5	-0.7	0.1
High blood pressure (siblings)	0.2	0.3	0.5	0.7	0.2
Forced vital capacity (FVC), Best measure	0.2	0.7	1.3	1.1	-0.4
Age at first live birth	0.2	0.4	0.8	-0.0	0.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	0.6	-0.1
Smoking status: Previous	0.2	0.3	0.3	0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.5	0.7	-0.5
Medication: Lisinopril	0.2	0.3	0.4	0.3	-0.7
Ever smoked	0.2	0.4	0.7	0.9	-0.2
Number of operations (self-reported)	0.2	0.3	0.5	0.7	-0.0
Diastolic blood pressure, automated reading	0.2	0.6	0.7	-0.8	-0.8
Cholesterol lowering medication	0.2	0.3	0.6	0.7	-0.3
Rheumatoid Arthritis	0.1	0.2	0.2	-0.4	0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	-0.2	-0.3
Blood Platelet Count	0.1	1.2	2.2	1.5	0.5
Tanning	0.1	1.6	1.8	1.2	1.3
Number of treatments/medications taken	0.1	0.1	0.1	0.4	0.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.3	0.4
Noisy workplace	0.1	0.1	0.2	-0.5	-0.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.4	-0.2
Glaucoma (self-reported)	0.1	0.1	0.1	0.3	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.6	0.2
Neck or shoulder pain in last month	0.1	0.2	0.2	0.4	0.4
Migraine (self-reported)	0.1	0.1	0.2	-0.5	0.2
Alcohol intake frequency.	0.1	0.2	0.3	0.6	0.3
Chest pain or discomfort	0.1	0.2	0.4	-0.6	-0.1
Leg pain on walking	0.1	0.1	0.1	-0.4	0.4
Long-standing illness, disability or infirmity	0.1	0.2	0.3	-0.6	0.1
Back pain experienced in last month	0.1	0.2	0.2	0.4	-0.4
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	0.6	0.1
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.6	0.1
Medication: Paracetamol	0.1	0.2	0.3	-0.5	-0.3
Unable to work because of sickness or disability	0.1	0.1	0.2	0.2	0.5
Pain experienced in last month	0.1	0.1	0.2	-0.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.1	-0.5
Crohns Disease (2017)	0.0	0.1	0.1	0.3	-0.2
Fasting Glucose	0.0	0.0	0.0	0.0	0.1
Blood White Count	0.0	0.1	0.1	-0.2	0.3
Waist Hip Ratio (WHR)	0.0	0.2	0.2	0.3	0.5
Hair Pigment	0.0	0.4	0.5	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	0.4	0.0
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.0	0.2	0.1
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	-0.2	0.2
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.2	-0.2
Eye problems/disorders: None of the above	0.0	0.1	0.1	0.0	-0.3
Suffer from ‘nerves’	0.0	0.0	0.1	-0.1	0.3
Commuting to job workplace: Cycle	0.0	0.0	0.0	0.2	0.1

Hub : Genes

NR3C1

Models

Trait associations