Hub : Genes

NRP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.049 0.022 1.3e-02 -0.001 0.015 0.007 0.015 0.008 4.1e-01 0.0048 4.1e-02 0.0058 3.2e-02
2 GTEx Brain Hippocampus 0.398 0.127 2.2e-03 -0.009 NA 0.037 NA -0.007 5.7e-01 NA 4.7e-02 NA 5.1e-01
3 GTEx Breast Mammary Tissue (Female) 0.294 0.107 2.3e-03 0.031 NA 0.049 NA 0.064 4.1e-02 NA 1.4e-02 NA 5.7e-03
4 GTEx Cells Transformed fibroblasts 0.200 0.059 3.9e-04 0.149 NA 0.140 NA 0.154 2.6e-11 NA 1.2e-10 NA 1.2e-11
5 GTEx Esophagus Muscularis 0.309 0.073 5.3e-04 0.140 NA 0.059 NA 0.112 8.2e-09 NA 1.9e-04 NA 2.6e-07
6 GTEx Lung 0.338 0.064 1.6e-05 0.181 NA 0.121 NA 0.164 7.6e-14 NA 1.7e-09 NA 1.5e-12
7 TCGA Colon Adenocarcinoma 0.108 0.054 7.9e-03 -0.003 0.030 0.009 NA 0.005 4.9e-01 0.0071 8.7e-02 NA 1.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.3 2.0 5.1 0.1 -1.7 2.2 1.9 1.0 1.0 0.8
Bipolar Disorder or Schizophrenia 1.4 3.4 10.6 0.6 -2.8 3.2 1.8 0.7 0.7 1.1
Depressed Affect (Nagel 2018) 0.7 1.5 3.3 -1.1 -0.9 0.6 -0.4 -1.6 -1.8 -1.5
Depression (Nagel 2018) 0.5 0.7 2.8 -1.3 -0.3 1.7 -0.1 -0.1 -0.1 -0.7
Intelligence (Savage-Jansen 2018) 0.7 2.0 4.0 -0.6 1.8 -1.0 -1.5 2.0 1.7 -0.8
Neuroticism (Nagel 2018) 1.4 3.4 7.1 -2.3 -1.5 0.9 -1.4 -1.6 -2.0 -2.7
Schizophrenia (2018) 0.7 1.5 5.5 0.6 -1.9 2.3 0.7 0.1 0.1 0.7
Schizophrenia vs Biploar Disorder 0.1 0.1 0.7 0.2 0.2 0.1 0.0 -0.1 -0.0 0.8
Worry (Nagel 2018) 1.9 4.0 10.4 -1.3 -3.2 0.8 -2.0 -0.5 -0.9 -3.2
Alzheimer’s Disease (in mother) 0.7 0.9 2.0 0.6 -1.4 0.0 -1.0 0.7 0.5 -1.4
Alzheimer’s Disease (in father) 0.9 1.0 3.2 -0.2 -0.1 0.2 -0.5 1.8 1.8 -0.5
Alzheimer’s Disease (including proxy) 1.2 1.7 5.2 -0.2 -1.1 0.6 -0.2 2.3 2.1 -0.9
Crohns Disease (2017) 0.3 0.8 3.1 -0.4 1.3 -1.8 -0.2 0.4 0.1 0.2
Irritable Bowel Disease (IBD) 0.3 0.6 3.2 0.2 1.0 -1.8 -0.2 0.3 0.2 -0.1
Ulcerative Colitis (UC) 0.2 0.4 0.8 0.7 0.0 -0.9 -0.4 0.7 0.7 -0.4
Major Depression (MDD) 0.7 0.9 1.4 -1.2 0.6 -1.1 1.1 0.9 0.6 -1.0
Reaction Time 0.3 0.6 1.8 -0.6 -1.0 0.7 -0.9 -0.0 -0.0 -1.4
Verbal and Numeric Reasoning (VNR) 0.6 1.5 6.4 -0.1 2.5 -1.5 -1.1 0.6 0.4 -0.5
Breast Cancer 0.6 1.5 4.9 0.5 0.9 -2.2 -0.8 0.9 0.8 -1.5
Ovarian Cancer 0.1 0.2 0.6 0.3 -0.5 0.0 -0.0 0.4 -0.0 -0.8
Prostate Cancer 1.4 1.9 5.3 0.0 0.7 0.2 -1.3 -2.3 -2.1 -1.3
Age at First Birth 1.3 1.9 3.0 -0.7 -1.7 1.4 -1.6 1.5 1.7 0.4
Bipolar Disorder (2011) 1.7 1.6 7.6 -0.2 -1.9 2.8 -0.3 -0.3 -0.2 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 1.1 -0.5 0.1 -0.9 -1.1 0.7 0.7 -0.5
Coronary Artery Disease (CAD) 2.0 2.4 5.7 2.4 -1.2 1.1 2.2 -0.8 -0.8 1.5
Crohns Disease (2012) 0.1 0.2 1.0 -1.0 0.0 0.3 -0.0 -0.0 -0.1 -0.6
Mean Putamen Volume 0.7 0.8 2.2 -0.6 0.0 1.0 -1.5 -0.5 -0.5 -1.1
Fasting Glucose 0.3 0.3 1.2 0.3 0.0 0.6 1.1 0.2 0.3 0.7
HbA1C 0.9 1.0 3.7 1.9 -0.4 1.7 0.4 -0.5 -0.3 -0.3
HDL Cholesterol 0.4 0.7 1.3 -0.7 -1.1 0.4 -0.8 -0.6 -0.9 -1.1
LDL Cholesterol 0.5 0.8 1.8 0.4 -0.0 -0.5 1.2 1.4 1.2 0.9
Lupus 0.2 0.2 0.6 -0.2 -0.0 0.3 0.8 0.7 0.6 -0.1
Neuroticism (2016) 1.2 1.8 6.4 -0.6 -0.2 0.4 0.1 -2.2 -2.5 -0.9
Primary Biliary Cirrhosis 0.3 0.4 0.9 0.4 -0.7 -0.3 1.0 0.7 0.6 0.2
Rheumatoid Arthritis 0.6 0.8 2.8 -0.6 1.7 -0.6 -0.9 -0.6 -0.7 0.3
Schizophrenia (2014) 1.1 2.4 7.8 1.1 -2.1 2.8 1.2 0.7 0.7 1.1
Triglycerides 0.6 1.0 2.4 0.1 0.1 1.3 -0.0 1.6 1.5 0.6
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.8 -0.7 0.9 -0.9 -0.1 -0.5 -0.4 -0.1
Ulcerative Colitis 0.2 0.3 1.1 0.1 0.1 0.3 -0.1 0.9 1.1 -0.5
Blood Eosinophil Count 0.1 1.1 1.6 0.9 -1.2 -0.3 1.1 1.1 1.3 1.0
Blood Platelet Count 0.2 2.6 8.5 0.7 1.2 -0.2 0.5 -2.8 -2.9 0.0
Blood Red Count 0.1 0.8 3.6 0.5 -0.5 -0.2 -0.2 -1.0 -0.5 1.9
Blood White Count 0.3 2.3 5.0 1.9 0.8 1.7 1.1 -1.2 -1.0 2.2
Heel T-Score 0.2 2.0 4.0 -1.9 0.1 -1.3 -1.2 1.8 2.0 0.2
BMI 0.5 3.0 11.5 -0.2 3.4 -1.6 0.9 1.6 1.8 0.5
Height 0.1 2.7 9.2 -1.4 -3.0 0.5 -0.1 2.0 1.8 -0.3
Waist Hip Ratio (WHR) 0.9 4.2 19.3 1.0 -0.8 4.4 2.6 0.8 1.0 0.2
Systolic Blood Pressure 0.4 2.0 5.5 -1.9 -0.2 -0.9 -2.3 1.3 1.5 -0.2
Smoking Status 0.4 1.0 3.2 0.2 1.1 -0.5 1.8 -0.5 -0.4 1.3
Allergy or Eczema 0.6 1.6 7.5 0.0 0.9 -2.7 -1.4 0.5 0.5 0.0
Cardiovascular Disease 0.4 1.2 3.3 0.8 -0.4 0.2 -1.3 -1.8 -1.6 -0.1
Hypothyroidism (self reported) 0.4 0.9 3.8 -1.0 -0.7 1.9 -0.3 -0.7 -0.5 -0.1
Respiratory disease 0.4 1.0 2.4 0.5 1.1 -0.9 -0.1 -1.6 -1.4 -0.2
Type 2 Diabetes (T2D) (2018) 1.3 2.4 7.5 -0.7 0.2 -1.0 -0.4 2.7 2.6 0.5
Lung FEV1/FVC ratio 3.1 15.8 42.4 1.7 0.6 1.3 2.4 6.0 6.5 4.6
Lung FVC 0.3 1.7 6.2 1.6 0.1 0.1 1.7 -0.1 0.3 2.5
Neuroticism 1.4 3.3 6.3 -1.3 -1.6 1.4 -0.8 -2.0 -2.5 -2.4
Chronotype (morning person) 1.0 2.3 6.0 -0.7 1.1 -2.4 -2.4 0.9 0.7 -1.1
Hair Pigment 0.1 3.9 9.7 1.1 1.1 1.8 1.2 2.9 3.1 1.6
Tanning 0.1 1.4 4.2 -0.5 -1.2 -0.9 -2.0 0.3 0.3 -1.6
Hand grip strength (left) 0.4 1.0 6.2 -0.9 -0.1 -2.5 -0.0 -0.1 -0.1 -0.4
Number of treatments/medications taken 1.3 2.3 4.5 2.1 -1.2 1.3 0.4 -2.0 -2.0 -0.2
Average weekly spirits intake 0.4 0.5 0.9 1.0 0.2 0.9 -0.1 -1.0 -0.8 0.6
Sensitivity / hurt feelings 1.2 2.0 4.0 -2.0 0.8 0.2 -1.0 -1.4 -1.6 -1.9
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.4 0.7 -0.6 0.8 1.2 -0.9 -1.0 0.4
Hearing difficulty/problems: Yes 0.8 1.2 3.7 1.9 -0.9 1.9 -0.0 -0.1 -0.1 0.6
Relative age of first facial hair 1.3 2.7 7.8 -2.8 -0.8 0.1 -1.5 0.8 0.7 -2.6
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 8.2 0.1 -1.2 2.9 -1.0 -0.1 -0.1 -0.4
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.2 0.0 -0.3 -0.0 -0.5 1.1 0.8 -0.9
Ever had hysterectomy (womb removed) 0.5 0.6 1.1 1.1 -0.1 0.9 -0.9 0.9 0.8 0.2
Systolic blood pressure, automated reading 0.4 1.1 3.1 -1.2 0.2 -0.9 -1.8 1.0 1.1 -0.4
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.8 -0.9 -0.2 0.6 -0.7 0.1 -0.1 -0.3
Angina 1.5 1.9 4.4 1.4 0.5 -1.3 2.1 1.5 1.6 0.6
Medication for hormone replacement therapy 0.2 0.3 0.5 0.5 -0.7 0.7 0.2 0.3 0.1 -0.6
Vitamin and mineral supplements 1.8 2.5 9.6 -3.1 1.3 -1.1 -1.5 1.2 1.1 -0.3
Supplements: Zinc 0.5 0.6 2.6 0.8 1.6 -0.6 0.6 0.1 -0.1 0.4
Medication: Co-codamol 0.4 0.4 1.2 -0.1 -0.5 0.3 0.6 0.8 0.7 1.1
Medication: Metformin 0.3 0.4 2.2 -1.5 -0.1 -0.3 -0.5 0.4 0.1 0.5
Diabetes (father) 0.2 0.2 0.8 -0.0 0.0 -0.9 0.2 0.3 0.0 -0.6
Diabetes (mother) 0.6 0.8 3.3 -0.6 1.1 0.0 -1.8 -0.4 -0.3 0.6
Severe depression (siblings) 0.3 0.3 0.9 0.3 -0.9 0.1 0.6 0.7 0.5 -0.1
Pack years adult smoking proportion 0.8 1.3 5.2 -2.3 -0.1 1.6 -0.2 0.6 0.5 -0.9
Impedance of leg (right) 0.8 4.0 8.5 2.1 -2.1 2.9 1.9 -0.9 -1.0 2.2
Leg fat-free mass (left) 0.3 1.8 3.3 -1.3 1.7 -1.8 -0.1 1.5 1.5 -0.7
Trunk fat percentage 0.6 2.4 7.7 -0.5 1.0 2.8 0.1 1.9 2.0 -0.2
Hand grip strength (right) 0.4 1.0 4.6 0.2 0.7 -2.1 0.4 -0.8 -0.7 0.5
Townsend deprivation index at recruitment 0.2 0.3 0.9 -0.9 -0.2 0.2 -0.4 -0.2 -0.3 -0.8
Current tobacco smoking 0.5 0.9 1.9 -0.8 1.4 0.2 1.2 -0.9 -0.7 0.8
Average weekly fortified wine intake 2.1 2.5 5.0 -1.3 -1.8 -0.8 -1.7 2.2 2.0 -0.3
Maternal smoking around birth 1.3 1.9 4.9 0.8 2.0 1.2 1.6 0.1 0.3 2.2
Fed-up feelings 1.2 2.2 7.7 0.1 0.3 -0.7 0.9 -2.5 -2.8 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 3.0 -0.3 -0.9 1.7 0.5 -1.0 -1.2 -0.5
Relative age voice broke 1.4 2.2 6.5 -2.3 -0.2 0.3 -0.4 1.3 1.2 -2.5
Taking other prescription medications 1.3 1.9 5.4 2.3 0.0 0.1 0.4 -2.0 -1.9 0.8
Age when periods started (menarche) 0.2 0.4 2.0 0.5 -0.3 -1.4 0.6 -0.1 -0.0 0.2
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.1 0.6 -1.0 0.9 0.2 1.0 0.9 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.7 0.1 -0.1 -0.1 0.8 0.1 0.1 0.8
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 4.7 0.4 -2.2 0.6 -0.2 -1.9 -1.9 -0.9
Qualifications: CSEs or equivalent 0.6 0.8 2.2 -1.5 1.0 -0.8 0.3 0.7 0.5 -1.0
Serious illness, injury or assault to yourself 0.8 0.9 2.9 1.3 -0.5 0.4 1.7 0.2 0.3 1.2
High blood pressure 0.2 0.5 1.3 0.1 -0.2 1.1 -0.7 -1.0 -0.8 -0.6
Hayfever, allergic rhinitis or eczema 0.7 1.5 7.7 0.3 0.5 -2.8 -1.4 0.2 0.2 -0.4
Multivitamins +/- minerals 1.8 2.3 7.7 2.8 -0.7 1.2 1.8 -1.4 -1.3 0.4
Stomach or abdominal pain in last month 0.3 0.4 1.4 0.2 0.1 1.2 0.2 0.4 0.2 -0.9
Supplements: Glucosamine 1.7 2.2 5.7 0.3 -2.1 2.4 -2.2 0.0 0.0 -0.4
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.1 -0.8 0.3 0.8 -0.5 -1.0 -1.1 -0.8
Medication: Atenolol 0.7 0.9 3.5 -0.5 -0.6 0.7 -1.0 0.7 0.7 -1.9
Medication: Levothyroxine sodium 0.6 1.0 2.4 -1.1 0.2 1.0 -0.5 -1.1 -1.0 -1.6
Sitting height 0.1 1.0 2.9 -0.4 -1.7 1.2 0.6 1.1 0.9 0.4
Chronic bronchitis/emphysema (father) 0.5 0.6 1.4 -1.2 0.2 -0.6 -0.1 -0.9 -1.1 0.5
High blood pressure (mother) 2.3 3.3 7.4 1.2 -0.7 2.5 1.2 -2.4 -2.7 0.4
Body mass index (BMI) 0.6 2.4 9.2 -0.6 3.0 -1.0 0.0 1.6 1.8 0.2
Impedance of leg (left) 0.7 3.5 10.5 1.4 -2.7 3.2 1.2 -0.8 -1.0 1.2
Leg predicted mass (left) 0.3 1.8 3.2 -1.1 1.8 -1.7 0.0 1.5 1.5 -0.5
Trunk fat mass 0.5 2.1 4.3 -1.0 1.6 1.7 0.1 2.0 2.1 -0.2
Waist circumference 0.6 2.1 5.6 -0.9 1.6 1.1 0.4 2.1 2.4 0.1
Number of incorrect matches in round 0.9 1.5 3.9 -2.0 -1.9 0.5 -0.6 -0.3 -0.3 -1.6
Past tobacco smoking 0.6 1.2 3.7 -0.8 -0.4 1.2 -1.9 -1.0 -1.0 -0.6
Alcohol usually taken with meals 0.2 0.3 1.2 0.4 -0.9 -0.2 1.1 -0.1 0.0 0.2
Nervous feelings 2.0 3.7 8.2 -2.0 -2.8 -0.2 -2.0 -0.9 -1.0 -2.9
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 6.2 -0.3 -2.5 0.7 -0.1 -1.2 -1.3 -0.6
Hearing difficulty/problems with background noise 1.1 1.8 5.0 0.3 -2.2 2.2 -1.0 -0.9 -0.7 -0.6
Hair/balding pattern: Pattern 2 1.4 1.8 5.5 2.3 -2.2 1.1 -0.9 -0.1 -0.1 -0.2
Had menopause 1.6 2.0 5.8 -2.4 -0.1 1.0 -1.5 0.9 0.8 -1.8
Had other major operations 0.3 0.4 0.9 0.7 0.7 0.9 0.3 -0.3 -0.1 0.9
Forced vital capacity (FVC) 0.4 1.4 5.2 1.2 0.5 0.1 1.7 -0.4 -0.3 2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.1 -1.0 0.0 -0.4 0.9 0.7 0.8 -0.2
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.2 1.3 -0.5 1.5 1.3 -0.5 -0.6 1.0
Qualifications: None of the above 0.1 0.3 0.9 -0.1 -1.0 -0.2 -0.2 -0.5 -0.6 -0.4
Financial difficulties in last 2 years 1.1 1.5 4.2 2.0 0.5 0.6 1.1 -0.2 -0.3 2.1
Mouth/teeth dental problems 0.4 0.6 1.3 -0.5 -0.8 -1.0 -1.1 0.5 0.7 -0.0
Heart attack 0.2 0.2 1.2 0.1 0.2 -1.1 0.5 0.2 0.1 -0.4
Allergy 0.6 1.3 6.0 -1.3 -1.1 2.5 0.4 0.1 -0.0 0.0
Pain all over the body in last month 0.8 0.9 4.2 -0.0 -2.1 0.3 0.6 0.9 0.7 -0.0
Diabetes (self-reported) 0.7 1.1 2.4 -0.2 -0.5 -1.3 0.2 1.5 1.3 1.3
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 2.4 0.2 1.0 -1.5 -1.3 0.1 0.1 -0.1
Medication: Ramipril 0.1 0.1 0.8 0.2 -0.2 -0.9 0.2 -0.2 -0.2 0.3
Medication: Simvastatin 0.1 0.2 0.5 0.3 0.2 -0.7 -0.7 0.2 0.0 -0.4
Fluid intelligence score 0.7 1.5 2.7 0.5 1.5 -1.6 -0.3 -1.4 -1.6 -0.9
Illnesses of siblings 0.6 0.8 2.1 0.0 0.2 0.7 0.4 1.4 1.3 1.0
Neuroticism score 1.4 3.0 8.5 -0.7 -1.1 0.4 -0.3 -2.5 -2.9 -2.1
Weight 0.5 2.3 5.5 -0.8 2.0 -0.7 0.3 2.2 2.3 0.1
Impedance of arm (right) 1.2 5.6 27.5 0.8 -3.3 5.2 -0.7 -0.0 -0.3 -0.3
Arm fat percentage (right) 0.5 2.1 4.2 -0.9 2.0 1.6 -0.4 1.8 2.0 -0.2
Trunk fat-free mass 0.7 3.9 13.5 -1.9 2.1 -3.7 -0.2 1.6 1.7 -0.4
Hip circumference 0.5 2.3 5.2 -1.7 2.3 -0.7 -1.0 1.7 1.8 -0.4
Time employed in main current job 1.1 1.3 4.0 -0.2 -0.9 1.1 0.6 -1.2 -1.0 -2.0
Alcohol intake versus 10 years previously 0.3 0.5 1.6 -1.3 1.1 -0.1 -0.7 0.2 0.3 0.0
Father’s age at death 0.1 0.1 0.7 -0.2 0.4 -0.1 -0.4 -0.1 -0.2 -0.8
Worrier / anxious feelings 1.7 3.1 6.9 -0.8 -1.3 0.8 -1.0 -2.3 -2.6 -2.4
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 3.1 0.4 -0.3 0.2 0.7 -1.4 -1.8 -0.1
Falls in the last year 0.2 0.3 1.0 0.1 -0.7 1.0 0.2 0.7 0.6 0.1
Hair/balding pattern: Pattern 3 1.9 2.8 6.7 -0.4 2.6 -2.0 2.3 -1.2 -1.3 0.5
Number of live births 0.2 0.2 1.3 0.5 -0.2 0.2 -1.2 -0.2 -0.2 -0.1
Forced expiratory volume in 1-second (FEV1) 0.9 3.0 10.3 1.9 -0.1 0.4 1.8 1.3 1.5 3.2
Pulse rate 0.8 1.3 2.7 -1.4 0.1 0.5 -0.8 1.3 1.3 1.6
Happiness 1.8 2.2 6.6 1.2 0.6 -0.8 -0.3 -2.6 -2.5 0.2
Noisy workplace 1.4 1.7 6.0 2.5 -1.4 -0.7 -0.8 -1.1 -0.8 0.8
Qualifications: A levels/AS levels or equivalent 0.6 1.3 5.6 2.4 -0.6 1.1 0.2 0.2 0.5 1.1
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.3 1.4 -1.0 -1.4 -0.9 -1.5 -1.5 0.7
Mouth/teeth dental problems: Dentures 0.2 0.3 1.5 -0.0 -0.7 -1.2 0.1 0.1 -0.1 -0.0
Asthma 0.6 1.2 3.9 0.5 2.0 -1.8 0.2 -0.9 -0.7 0.1
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 5.9 -0.7 0.6 1.2 -0.3 -2.1 -2.4 -0.4
Medication: Cholesterol lowering 0.4 0.6 2.5 0.5 -1.6 -0.5 0.7 -0.7 -0.8 -0.0
Depression (self-reported) 0.2 0.3 1.1 0.1 1.1 0.5 -0.3 0.3 0.1 0.4
Medication: Lansoprazole 3.0 3.4 8.9 2.3 -0.4 1.1 0.6 -3.0 -2.8 0.5
Prospective memory result 0.4 0.5 1.4 -0.2 0.3 0.5 1.1 0.2 0.4 1.2
Lung cancer (father) 0.4 0.5 1.5 0.1 0.2 0.4 1.2 0.5 0.5 1.0
Illnesses of mother 1.5 1.8 6.3 -0.6 0.3 -0.3 0.1 2.4 2.5 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 4.7 1.0 -0.6 1.0 0.9 1.6 1.8 2.2
Pulse wave Arterial Stiffness index 0.8 0.9 2.8 -0.9 1.7 0.2 1.7 0.2 0.2 0.4
Impedance of arm (left) 1.5 6.9 34.6 0.8 -3.6 5.9 -0.3 -0.0 -0.3 0.0
Arm fat mass (right) 0.5 2.1 5.6 -0.9 2.4 0.3 0.0 1.9 2.1 0.1
Trunk predicted mass 0.7 3.8 14.0 -1.9 2.1 -3.7 -0.2 1.5 1.6 -0.4
Standing height 0.1 1.2 2.7 -0.9 -1.6 0.3 0.6 1.6 1.4 -0.4
Length of working week for main job 0.3 0.3 1.3 -0.8 0.1 0.5 0.0 -0.2 -0.2 -1.1
Exposure to tobacco smoke at home 2.5 2.8 5.8 1.2 1.8 0.7 1.3 -2.4 -2.1 1.8
Breastfed as a baby 1.0 1.3 3.5 -1.9 0.5 1.1 -1.5 0.5 0.4 -1.3
Tense / ‘highly strung’ 1.6 2.6 4.8 0.1 -2.2 1.7 -0.7 -1.5 -1.9 -2.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.6 5.4 -1.0 1.2 1.8 -0.8 -2.3 -2.3 -1.2
Hair/balding pattern: Pattern 4 1.2 3.0 6.2 2.2 1.2 0.7 2.5 -2.1 -1.9 0.2
Birth weight of first child 0.2 0.3 0.9 -0.8 -0.5 -0.9 0.3 -0.1 0.1 -0.6
Peak expiratory flow (PEF) 0.7 1.6 5.7 1.3 -0.6 -0.1 0.8 1.1 1.2 2.4
Pulse wave reflection index 0.7 0.9 3.3 0.1 1.5 0.3 1.8 0.3 0.6 0.3
Ever highly irritable/argumentative for 2 days 2.1 2.5 8.1 -0.6 0.7 0.6 -0.4 -2.5 -2.8 -1.3
Loud music exposure frequency 0.7 0.7 1.4 0.3 -1.2 -0.9 0.3 -1.0 -1.2 -0.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.7 1.1 0.5 -0.3 0.3 1.3 1.0 0.5
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 5.9 0.9 -0.3 2.4 1.2 -1.6 -1.7 1.0
Blood clot in the leg (DVT) 1.2 1.5 4.6 2.1 1.4 -0.5 1.7 0.4 0.7 0.8
Medication: Paracetamol 0.2 0.4 1.4 -0.1 0.6 -1.2 0.5 -0.6 -0.4 -0.4
Headache pain in last month 0.2 0.3 1.3 0.2 -0.0 -0.2 -0.5 -1.1 -0.9 0.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.5 -0.1 0.9 -0.1 -0.8 -1.2 -1.1 0.7
Glaucoma (self-reported) 0.8 1.0 3.4 0.1 -0.7 1.7 -0.4 -0.1 0.0 1.8
Gout (self-reported) 0.5 0.6 1.5 -0.4 0.5 -0.5 0.9 1.0 1.2 0.6
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.4 -0.5 -0.5 1.6 -0.1 -0.8 -0.5 -0.5
Medication: Amlodipine 0.5 0.7 2.0 -0.4 1.2 -0.8 -0.8 -0.3 0.0 -1.4
Medication: Ventolin 100micrograms inhaler 0.5 0.7 2.4 0.0 0.4 -1.5 1.3 0.0 0.1 0.6
Birth weight 1.2 2.6 6.8 -2.6 0.3 -1.6 -2.3 0.3 0.2 -1.9
Chronic bronchitis/emphysema (mother) 0.8 1.0 4.3 0.5 -0.9 2.1 0.1 -0.2 -0.1 1.2
High blood pressure (siblings) 1.5 2.2 6.7 0.1 1.1 -0.1 0.1 -2.6 -2.5 -1.0
Forced vital capacity (FVC), Best measure 0.1 0.2 1.1 -0.0 -0.2 0.6 0.3 -0.1 -0.1 1.1
Body fat percentage 0.4 1.7 5.0 -0.2 1.4 2.2 0.3 1.5 1.6 0.2
Leg fat percentage (right) 0.5 1.7 4.3 0.6 2.1 1.1 1.1 0.9 1.1 1.6
Arm fat-free mass (right) 0.6 3.2 11.0 -1.4 2.0 -3.3 0.2 1.6 1.7 -0.1
Exposure to tobacco smoke outside home 1.9 2.5 6.6 0.5 1.7 -0.5 0.7 -2.6 -2.5 1.0
Comparative body size at age 10 1.4 3.8 11.0 -1.8 3.3 1.6 -1.5 -1.3 -1.6 -1.9
Number of full brothers 1.2 1.6 3.8 1.8 -0.8 -0.9 1.6 -0.1 0.1 2.0
Worry too long after embarrassment 1.4 2.4 5.6 -1.8 -0.6 2.3 -0.8 -0.7 -1.3 -2.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 6.0 -0.2 0.5 1.4 -0.8 -2.5 -2.4 -0.1
Wheeze or whistling in the chest in last year 1.5 2.8 7.2 1.0 0.4 1.2 1.2 -2.7 -2.4 1.4
Number of children fathered 1.5 1.7 3.0 0.9 -0.8 -1.3 1.5 1.6 1.7 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.2 -0.2 -0.4 0.0 -0.4 0.1 0.5 -0.2
Age at first live birth 0.3 0.5 2.2 0.3 0.5 0.8 0.1 0.5 0.5 1.5
Pulse wave peak to peak time 0.9 1.0 3.1 0.9 -1.8 -0.2 -1.6 -0.4 -0.5 -0.5
Health satisfaction 0.7 1.0 2.0 1.0 1.3 0.5 0.1 -1.4 -1.4 -0.3
Shortness of breath walking on level ground 2.0 2.3 7.6 2.8 0.6 0.5 1.4 -1.6 -1.2 1.6
Qualifications: College or University degree 0.3 1.1 2.5 0.4 0.9 0.7 -1.6 1.1 1.3 1.0
Eye problems/disorders: None of the above 0.9 1.0 2.4 -0.5 -0.7 -1.2 -0.3 1.0 1.1 -1.5
Mouth/teeth dental problems: Loose teeth 0.7 0.9 3.2 -0.3 0.4 1.8 0.9 -0.9 -1.0 -0.1
Emphysema/chronic bronchitis 1.9 2.2 5.2 0.9 -2.3 1.9 1.7 1.4 1.0 0.4
Medication for pain relief, constipation, heartburn 0.6 1.1 3.2 -0.9 0.1 -0.5 -0.5 1.7 1.8 0.6
Neck or shoulder pain in last month 0.9 1.3 3.0 -0.6 1.7 -0.5 0.1 -1.6 -1.5 -0.5
Medication: Blood pressure 0.8 1.4 3.7 0.1 -0.5 0.6 0.3 1.9 1.9 -1.2
Angina (self-reported) 1.3 1.7 3.2 1.4 0.6 -1.4 1.8 1.4 1.5 0.3
Migraine (self-reported) 0.5 0.6 3.0 -1.7 0.0 -0.9 -0.5 -0.1 -0.3 -0.5
Medication: Ibuprofen 1.4 1.7 5.7 -0.3 0.1 1.0 -0.4 -2.1 -2.4 -0.8
Medication: Allopurinol 0.4 0.6 2.4 0.3 -1.6 0.4 1.0 0.2 0.4 -0.2
Medication: Omeprazole 0.8 1.0 4.8 2.2 0.0 0.1 1.3 0.0 0.2 0.4
Medication: Seretide 50 evohaler 0.9 1.0 2.2 1.4 0.8 -0.0 -0.0 -1.5 -1.4 -0.8
Mean time to correctly identify matches 0.3 0.6 1.7 -0.8 -0.6 0.5 -0.5 0.7 0.8 -1.3
Heart disease (mother) 0.5 0.6 1.2 1.1 -0.4 -0.6 0.9 -0.8 -0.9 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.8 6.1 -0.8 -1.9 -2.5 -1.5 0.0 -0.0 -0.4
Whole body fat mass 0.4 1.8 3.8 -0.8 1.9 1.1 0.3 1.8 1.9 0.0
Leg fat mass (right) 0.5 1.9 5.4 -0.2 2.3 0.3 1.1 1.6 1.8 0.9
Arm predicted mass (right) 0.7 3.7 10.8 -1.7 2.1 -3.3 0.2 1.9 2.0 -0.1
Pulse rate, automated reading 1.0 3.2 6.2 -2.5 0.5 1.3 -1.9 2.3 2.4 0.1
Alcohol intake frequency. 0.4 0.9 3.3 -0.2 1.8 -1.1 0.7 -0.8 -0.5 0.7
Comparative height size at age 10 0.2 1.2 3.2 -0.3 -0.7 1.0 0.8 1.7 1.8 0.2
Number of full sisters 0.4 0.5 1.6 -0.4 0.6 -0.5 1.3 -0.3 -0.3 -0.9
Suffer from ‘nerves’ 1.3 2.0 7.7 -0.5 -2.3 0.3 -0.3 -0.5 -0.7 -2.8
Overall health rating 0.4 0.9 2.6 -0.3 1.6 0.5 0.1 -0.9 -1.2 -1.0
Chest pain or discomfort 0.4 0.6 1.8 0.2 -0.3 1.3 -0.0 -1.2 -1.0 -0.5
Had major operations 0.4 0.5 1.1 0.6 -0.2 1.0 0.3 -1.1 -0.9 -0.3
Age at last live birth 0.9 1.4 6.8 0.7 -0.7 2.6 0.5 -0.3 -0.3 1.1
Family relationship satisfaction 0.2 0.3 1.3 0.4 0.3 -0.4 -0.1 -0.4 -0.5 1.1
Leg pain on walking 0.3 0.4 2.0 1.4 0.3 -0.1 0.5 0.1 0.1 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.5 1.4 1.0 0.6 1.6 -0.4 -0.5 0.2
Commuting to job workplace: Car/motor vehicle 2.8 3.3 6.7 1.7 1.3 1.1 1.1 -2.5 -2.6 1.6
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.6 -0.9 0.2 1.6 0.3 -0.1 0.1 -0.6
Medication: Aspirin 0.3 0.4 1.2 0.4 -0.6 0.4 -0.9 -0.1 -0.3 -1.1
Supplements: Vitamin C 0.5 0.6 2.9 1.7 -0.1 -0.2 0.9 -0.4 -0.5 -0.1
Knee pain experienced in last month 0.4 0.6 1.4 0.5 -0.8 -1.0 0.6 -1.2 -0.9 0.1
Hypertension (Self-reported) 0.2 0.6 1.1 0.4 -0.4 1.1 -0.6 -0.9 -0.7 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 6.9 1.5 1.1 1.5 1.1 -2.6 -2.2 0.3
Illnesses of father: Heart disease 0.5 0.7 2.2 0.8 0.4 -0.4 0.2 -1.2 -1.5 0.1
Illnesses of siblings: Diabetes 0.1 0.1 0.3 -0.3 -0.5 0.2 0.1 -0.1 0.1 -0.6
Smoking status: Previous 0.9 1.4 3.3 1.4 -0.3 -1.8 1.6 0.9 0.8 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 4.8 0.2 -1.0 2.2 2.0 0.6 0.4 0.2
Whole body fat-free mass 0.5 3.0 9.4 -1.7 1.9 -3.1 -0.2 1.6 1.6 -0.6
Leg fat-free mass (right) 0.4 2.2 3.3 -1.8 1.3 -1.7 -0.5 1.6 1.6 -1.3
Arm fat percentage (left) 0.5 2.0 4.5 -0.7 2.1 1.9 -0.1 1.6 1.7 0.0
Average weekly red wine intake 2.6 3.8 5.1 2.1 2.2 0.7 2.2 -2.2 -2.0 1.8
Handedness (chirality/laterality): Left-handed 1.2 1.5 2.4 -0.9 -0.7 -1.0 -1.6 1.5 1.4 -1.2
Mood swings 1.0 1.7 3.9 -1.3 1.4 -0.7 -0.0 -1.7 -2.0 -1.1
Loneliness, isolation 0.4 0.5 1.6 0.2 0.0 1.1 0.4 -0.8 -1.2 0.2
Long-standing illness, disability or infirmity 0.4 0.6 1.8 -0.0 -0.0 1.0 0.0 -1.3 -1.3 -0.1
Ever had bowel cancer screening 0.9 1.0 2.2 -1.1 -0.3 1.4 -1.2 0.3 0.4 -1.5
Diabetes diagnosed by doctor 0.6 1.0 3.0 -0.7 -1.0 -0.6 -0.4 1.7 1.5 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.2 -1.0 0.8 -0.6 -1.1 0.4 0.5 0.8
Friendships satisfaction 0.3 0.4 1.6 -0.3 0.0 1.3 -0.5 0.6 0.4 0.1
Qualifications: nursing, teaching 0.7 1.1 3.8 1.7 0.8 -0.4 -0.4 0.4 0.5 1.9
Commuting to job workplace: Walk 2.4 2.5 5.3 -1.6 0.4 -0.1 -2.3 2.1 1.8 -1.4
Eye problems/disorders: Cataract 1.6 1.9 3.7 1.2 1.9 1.1 1.5 -1.4 -1.2 1.1
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.8 0.5 0.7 0.9 0.9 0.0 0.1 0.7
Medication for cholesterol 0.5 0.7 3.1 -1.8 -0.6 -0.0 -0.4 0.7 0.7 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.6 1.3 0.4 0.7 1.2 -0.9 -1.0 0.2
Back pain experienced in last month 0.7 1.0 1.8 -1.0 0.2 0.8 -1.2 -1.3 -1.3 -0.7
Mineral and other dietary supplements 0.8 1.1 2.9 -0.6 1.5 -1.7 1.0 0.6 0.5 0.7
Breast cancer (self-reported) 1.0 1.2 6.1 -0.1 1.2 0.1 2.5 -0.1 0.4 0.9
Asthma (self-reported) 0.6 1.1 3.7 0.5 1.9 -1.7 -0.1 -0.8 -0.5 0.0
Osteoporosis (self-reported) 1.0 1.2 4.0 -1.4 -2.0 1.2 -0.8 0.5 0.4 -0.5
Osteoarthritis (self-reported) 0.6 0.8 1.7 -0.7 -1.2 0.2 0.3 1.2 1.3 -0.2
Medication: Aspirin 0.7 0.8 1.2 1.1 -1.1 1.0 -0.4 -0.7 -0.9 -1.0
Medication: Gliclazide 1.0 1.2 2.2 0.8 1.2 -0.9 0.7 -1.1 -1.2 1.5
Illnesses of father: None of the above (group 1) 0.3 0.3 0.9 -0.2 0.0 0.9 -0.2 0.7 0.9 -0.4
Smoking status: Current 0.5 0.7 1.9 -1.1 1.4 0.2 0.9 -0.7 -0.6 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.8 0.3 -0.7 0.4 -0.8 1.5 1.7 0.8
Whole body water mass 0.6 3.2 9.1 -1.8 2.1 -3.0 -0.2 1.6 1.6 -0.6
Leg predicted mass (right) 0.4 2.1 3.1 -1.8 1.4 -1.7 -0.5 1.6 1.6 -1.2
Arm fat mass (left) 0.5 2.1 6.0 -0.9 2.4 0.0 0.3 1.9 2.1 0.2
Number of self-reported non-cancer illnesses 1.1 1.8 5.7 1.3 0.6 0.1 -0.1 -2.4 -2.2 -0.3
Average weekly champagne plus white wine intake 0.9 1.2 3.5 -0.3 -0.7 1.9 -1.0 1.1 1.0 -1.0
Miserableness 0.8 1.4 4.6 -0.5 -0.7 0.7 -0.0 -1.6 -2.1 -1.2
Guilty feelings 2.0 3.0 6.8 -1.6 1.7 -0.6 0.3 -2.4 -2.6 -1.6
Wears glasses or contact lenses 0.1 0.1 0.3 -0.4 0.1 0.6 -0.2 0.3 0.5 -0.4
Ever taken oral contraceptive pill 0.9 1.0 4.0 0.7 -0.3 -1.0 2.0 0.1 0.1 1.1
Hearing aid user 1.4 1.5 3.3 1.8 -0.6 0.6 1.8 -0.5 -0.3 1.8
Mother’s age at death 2.1 2.6 10.2 -1.6 -3.2 0.1 -1.1 1.3 1.1 -1.3
Financial situation satisfaction 0.4 0.5 1.8 0.6 0.9 1.4 -0.1 -0.7 -0.5 -0.2
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.0 0.1 1.4 -1.3 0.1 -1.2 -0.9 0.3
Commuting to job workplace: Public transport 0.7 0.8 3.1 -0.7 -1.8 0.4 0.6 1.0 0.9 0.3
Eye problems/disorders: Glaucoma 0.7 0.8 2.5 -1.0 -0.7 0.3 -1.6 0.6 0.7 1.0
Medication: Blood pressure 1.1 2.2 5.8 1.6 0.4 0.7 -1.0 -2.4 -2.3 0.0
Pain type(s) experienced in last month: Hip pain 0.8 0.9 2.9 -1.7 1.6 -0.8 -0.5 -0.1 0.1 -0.7
Supplements: Fish oil (including cod liver oil) 0.9 1.2 2.9 1.1 -1.3 1.7 -0.7 -0.9 -0.9 -0.6
High cholesterol (Self-reported) 0.4 0.6 1.2 0.8 -0.5 -1.1 1.0 -0.1 -0.3 1.1
Medication: Bendroflumethiazide 0.7 1.1 6.3 0.4 2.5 0.3 0.7 -0.3 -0.0 -0.6
Medication: Paracetamol 0.3 0.4 0.9 0.6 0.4 -0.6 0.5 -0.7 -0.6 -0.9
Medication: Lisinopril 0.5 0.6 2.5 0.1 1.6 0.9 -0.5 0.2 0.3 -0.7
Medication: Atorvastatin 2.4 3.0 11.2 2.0 -0.1 -0.0 3.3 0.1 0.0 2.4
Illnesses of father: High blood pressure 0.8 1.0 3.1 -0.6 0.5 0.0 -1.8 -1.3 -1.3 -0.4
Alcohol drinker status: Never 0.3 0.4 1.0 0.6 0.2 -0.2 1.0 0.6 0.8 0.6
Ever smoked 0.3 0.5 1.7 0.6 0.4 0.2 1.3 0.6 0.8 0.1
Basal metabolic rate 0.5 2.8 6.4 -1.5 2.1 -2.5 0.1 1.7 1.8 -0.4
Leg fat percentage (left) 0.3 1.0 3.2 0.2 1.8 1.2 0.6 0.8 1.0 0.7
Arm fat-free mass (left) 0.7 3.6 10.3 -1.4 2.4 -3.2 -0.0 1.9 1.9 -0.2
Number of operations (self-reported) 0.4 0.5 1.7 1.3 1.1 0.1 0.6 -0.6 -0.4 0.1
Average weekly beer plus cider intake 1.6 2.3 4.9 -2.1 -1.5 -0.0 -2.0 -0.1 -0.5 -2.2
Irritability 0.4 0.6 2.1 -0.7 -0.6 -1.4 -0.4 -0.6 -0.9 0.5
Risk taking 0.7 1.0 3.6 -0.8 1.9 0.1 1.1 -0.6 -0.9 0.6
Ever had prostate specific antigen (PSA) test 0.6 0.6 1.6 1.2 -1.1 -0.3 -0.1 -0.6 -0.4 -1.1
Fractured/broken bones in last 5 years 0.4 0.5 1.4 -0.4 -0.4 1.2 -0.0 -0.4 -0.3 1.1
Age started oral contraceptive pill 0.3 0.4 1.0 0.2 -0.8 -0.4 0.0 1.0 1.0 -0.3
Diastolic blood pressure, automated reading 0.5 1.7 6.5 -2.1 0.6 0.4 -2.6 -0.0 0.1 -0.4
Ever depressed for a whole week 1.0 1.3 6.5 -0.9 -0.6 2.5 0.6 -0.5 -0.7 0.0
Unable to work because of sickness or disability 0.3 0.3 1.2 0.6 -1.1 0.1 -0.3 -0.4 -0.3 0.7
Commuting to job workplace: Cycle 1.6 1.9 4.3 -0.7 0.9 -1.2 -0.4 2.0 2.1 1.5
Myopia 1.3 1.9 3.6 0.7 -0.4 1.5 1.6 1.9 1.8 1.1
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.7 -0.2 -0.1 -0.7 0.8 0.8 0.7 0.8
Cholesterol lowering medication 1.0 1.5 5.0 2.2 0.5 -0.6 0.9 0.6 0.6 1.9
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 3.0 1.7 -0.4 -0.4 1.2 0.6 0.7 0.1
Pain experienced in last month 1.4 2.3 7.2 1.0 0.3 0.9 1.2 1.7 1.7 2.7
Supplements: Calcium 0.6 0.6 2.6 0.4 0.3 0.8 0.9 -0.1 0.1 1.6
Basal cell carcinoma (self-reported) 1.3 1.5 2.8 1.7 -0.4 0.8 0.9 -1.4 -1.6 1.1
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.9 0.5 -0.1 -1.0 0.8 0.3 0.3 -0.3
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 4.2 2.0 1.0 -0.7 1.6 0.2 0.5 0.7
Heart disease (siblings) 0.3 0.3 1.4 -0.7 -1.2 -0.2 -0.4 -0.0 0.1 0.1
Alcohol drinker status: Previous 0.7 0.8 1.5 -1.1 1.0 -0.9 -0.2 -1.2 -1.2 0.2
Pack years of smoking 1.1 1.7 6.9 -2.6 -0.2 1.4 -0.4 0.7 0.6 -1.2
Impedance of whole body 1.2 6.0 26.9 1.5 -3.3 5.2 0.7 -0.6 -0.8 0.9
Leg fat mass (left) 0.4 1.5 4.2 -0.5 2.1 0.4 0.7 1.5 1.6 0.4
Arm predicted mass (left) 0.7 3.7 12.0 -1.6 2.3 -3.5 -0.2 1.7 1.8 -0.4