Hub : Genes

NRP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.049	0.022	1.3e-02	-0.001	0.015	0.007	0.015	0.008	4.1e-01	0.0048	4.1e-02	0.0058	3.2e-02
2	GTEx	Brain Hippocampus	0.398	0.127	2.2e-03	-0.009	NA	0.037	NA	-0.007	5.7e-01	NA	4.7e-02	NA	5.1e-01
3	GTEx	Breast Mammary Tissue (Female)	0.294	0.107	2.3e-03	0.031	NA	0.049	NA	0.064	4.1e-02	NA	1.4e-02	NA	5.7e-03
4	GTEx	Cells Transformed fibroblasts	0.200	0.059	3.9e-04	0.149	NA	0.140	NA	0.154	2.6e-11	NA	1.2e-10	NA	1.2e-11
5	GTEx	Esophagus Muscularis	0.309	0.073	5.3e-04	0.140	NA	0.059	NA	0.112	8.2e-09	NA	1.9e-04	NA	2.6e-07
6	GTEx	Lung	0.338	0.064	1.6e-05	0.181	NA	0.121	NA	0.164	7.6e-14	NA	1.7e-09	NA	1.5e-12
7	TCGA	Colon Adenocarcinoma	0.108	0.054	7.9e-03	-0.003	0.030	0.009	NA	0.005	4.9e-01	0.0071	8.7e-02	NA	1.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.3	2.0	5.1	0.1	-1.7	2.2	1.9	1.0	1.0	0.8
Bipolar Disorder or Schizophrenia	1.4	3.4	10.6	0.6	-2.8	3.2	1.8	0.7	0.7	1.1
Depressed Affect (Nagel 2018)	0.7	1.5	3.3	-1.1	-0.9	0.6	-0.4	-1.6	-1.8	-1.5
Depression (Nagel 2018)	0.5	0.7	2.8	-1.3	-0.3	1.7	-0.1	-0.1	-0.1	-0.7
Intelligence (Savage-Jansen 2018)	0.7	2.0	4.0	-0.6	1.8	-1.0	-1.5	2.0	1.7	-0.8
Neuroticism (Nagel 2018)	1.4	3.4	7.1	-2.3	-1.5	0.9	-1.4	-1.6	-2.0	-2.7
Schizophrenia (2018)	0.7	1.5	5.5	0.6	-1.9	2.3	0.7	0.1	0.1	0.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.7	0.2	0.2	0.1	0.0	-0.1	-0.0	0.8
Worry (Nagel 2018)	1.9	4.0	10.4	-1.3	-3.2	0.8	-2.0	-0.5	-0.9	-3.2
Alzheimer’s Disease (in mother)	0.7	0.9	2.0	0.6	-1.4	0.0	-1.0	0.7	0.5	-1.4
Alzheimer’s Disease (in father)	0.9	1.0	3.2	-0.2	-0.1	0.2	-0.5	1.8	1.8	-0.5
Alzheimer’s Disease (including proxy)	1.2	1.7	5.2	-0.2	-1.1	0.6	-0.2	2.3	2.1	-0.9
Crohns Disease (2017)	0.3	0.8	3.1	-0.4	1.3	-1.8	-0.2	0.4	0.1	0.2
Irritable Bowel Disease (IBD)	0.3	0.6	3.2	0.2	1.0	-1.8	-0.2	0.3	0.2	-0.1
Ulcerative Colitis (UC)	0.2	0.4	0.8	0.7	0.0	-0.9	-0.4	0.7	0.7	-0.4
Major Depression (MDD)	0.7	0.9	1.4	-1.2	0.6	-1.1	1.1	0.9	0.6	-1.0
Reaction Time	0.3	0.6	1.8	-0.6	-1.0	0.7	-0.9	-0.0	-0.0	-1.4
Verbal and Numeric Reasoning (VNR)	0.6	1.5	6.4	-0.1	2.5	-1.5	-1.1	0.6	0.4	-0.5
Breast Cancer	0.6	1.5	4.9	0.5	0.9	-2.2	-0.8	0.9	0.8	-1.5
Ovarian Cancer	0.1	0.2	0.6	0.3	-0.5	0.0	-0.0	0.4	-0.0	-0.8
Prostate Cancer	1.4	1.9	5.3	0.0	0.7	0.2	-1.3	-2.3	-2.1	-1.3
Age at First Birth	1.3	1.9	3.0	-0.7	-1.7	1.4	-1.6	1.5	1.7	0.4
Bipolar Disorder (2011)	1.7	1.6	7.6	-0.2	-1.9	2.8	-0.3	-0.3	-0.2	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.1	-0.5	0.1	-0.9	-1.1	0.7	0.7	-0.5
Coronary Artery Disease (CAD)	2.0	2.4	5.7	2.4	-1.2	1.1	2.2	-0.8	-0.8	1.5
Crohns Disease (2012)	0.1	0.2	1.0	-1.0	0.0	0.3	-0.0	-0.0	-0.1	-0.6
Mean Putamen Volume	0.7	0.8	2.2	-0.6	0.0	1.0	-1.5	-0.5	-0.5	-1.1
Fasting Glucose	0.3	0.3	1.2	0.3	0.0	0.6	1.1	0.2	0.3	0.7
HbA1C	0.9	1.0	3.7	1.9	-0.4	1.7	0.4	-0.5	-0.3	-0.3
HDL Cholesterol	0.4	0.7	1.3	-0.7	-1.1	0.4	-0.8	-0.6	-0.9	-1.1
LDL Cholesterol	0.5	0.8	1.8	0.4	-0.0	-0.5	1.2	1.4	1.2	0.9
Lupus	0.2	0.2	0.6	-0.2	-0.0	0.3	0.8	0.7	0.6	-0.1
Neuroticism (2016)	1.2	1.8	6.4	-0.6	-0.2	0.4	0.1	-2.2	-2.5	-0.9
Primary Biliary Cirrhosis	0.3	0.4	0.9	0.4	-0.7	-0.3	1.0	0.7	0.6	0.2
Rheumatoid Arthritis	0.6	0.8	2.8	-0.6	1.7	-0.6	-0.9	-0.6	-0.7	0.3
Schizophrenia (2014)	1.1	2.4	7.8	1.1	-2.1	2.8	1.2	0.7	0.7	1.1
Triglycerides	0.6	1.0	2.4	0.1	0.1	1.3	-0.0	1.6	1.5	0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.8	-0.7	0.9	-0.9	-0.1	-0.5	-0.4	-0.1
Ulcerative Colitis	0.2	0.3	1.1	0.1	0.1	0.3	-0.1	0.9	1.1	-0.5
Blood Eosinophil Count	0.1	1.1	1.6	0.9	-1.2	-0.3	1.1	1.1	1.3	1.0
Blood Platelet Count	0.2	2.6	8.5	0.7	1.2	-0.2	0.5	-2.8	-2.9	0.0
Blood Red Count	0.1	0.8	3.6	0.5	-0.5	-0.2	-0.2	-1.0	-0.5	1.9
Blood White Count	0.3	2.3	5.0	1.9	0.8	1.7	1.1	-1.2	-1.0	2.2
Heel T-Score	0.2	2.0	4.0	-1.9	0.1	-1.3	-1.2	1.8	2.0	0.2
BMI	0.5	3.0	11.5	-0.2	3.4	-1.6	0.9	1.6	1.8	0.5
Height	0.1	2.7	9.2	-1.4	-3.0	0.5	-0.1	2.0	1.8	-0.3
Waist Hip Ratio (WHR)	0.9	4.2	19.3	1.0	-0.8	4.4	2.6	0.8	1.0	0.2
Systolic Blood Pressure	0.4	2.0	5.5	-1.9	-0.2	-0.9	-2.3	1.3	1.5	-0.2
Smoking Status	0.4	1.0	3.2	0.2	1.1	-0.5	1.8	-0.5	-0.4	1.3
Allergy or Eczema	0.6	1.6	7.5	0.0	0.9	-2.7	-1.4	0.5	0.5	0.0
Cardiovascular Disease	0.4	1.2	3.3	0.8	-0.4	0.2	-1.3	-1.8	-1.6	-0.1
Hypothyroidism (self reported)	0.4	0.9	3.8	-1.0	-0.7	1.9	-0.3	-0.7	-0.5	-0.1
Respiratory disease	0.4	1.0	2.4	0.5	1.1	-0.9	-0.1	-1.6	-1.4	-0.2
Type 2 Diabetes (T2D) (2018)	1.3	2.4	7.5	-0.7	0.2	-1.0	-0.4	2.7	2.6	0.5
Lung FEV1/FVC ratio	3.1	15.8	42.4	1.7	0.6	1.3	2.4	6.0	6.5	4.6
Lung FVC	0.3	1.7	6.2	1.6	0.1	0.1	1.7	-0.1	0.3	2.5
Neuroticism	1.4	3.3	6.3	-1.3	-1.6	1.4	-0.8	-2.0	-2.5	-2.4
Chronotype (morning person)	1.0	2.3	6.0	-0.7	1.1	-2.4	-2.4	0.9	0.7	-1.1
Hair Pigment	0.1	3.9	9.7	1.1	1.1	1.8	1.2	2.9	3.1	1.6
Tanning	0.1	1.4	4.2	-0.5	-1.2	-0.9	-2.0	0.3	0.3	-1.6
Hand grip strength (left)	0.4	1.0	6.2	-0.9	-0.1	-2.5	-0.0	-0.1	-0.1	-0.4
Number of treatments/medications taken	1.3	2.3	4.5	2.1	-1.2	1.3	0.4	-2.0	-2.0	-0.2
Average weekly spirits intake	0.4	0.5	0.9	1.0	0.2	0.9	-0.1	-1.0	-0.8	0.6
Sensitivity / hurt feelings	1.2	2.0	4.0	-2.0	0.8	0.2	-1.0	-1.4	-1.6	-1.9
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.4	0.7	-0.6	0.8	1.2	-0.9	-1.0	0.4
Hearing difficulty/problems: Yes	0.8	1.2	3.7	1.9	-0.9	1.9	-0.0	-0.1	-0.1	0.6
Relative age of first facial hair	1.3	2.7	7.8	-2.8	-0.8	0.1	-1.5	0.8	0.7	-2.6
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	8.2	0.1	-1.2	2.9	-1.0	-0.1	-0.1	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	0.0	-0.3	-0.0	-0.5	1.1	0.8	-0.9
Ever had hysterectomy (womb removed)	0.5	0.6	1.1	1.1	-0.1	0.9	-0.9	0.9	0.8	0.2
Systolic blood pressure, automated reading	0.4	1.1	3.1	-1.2	0.2	-0.9	-1.8	1.0	1.1	-0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.8	-0.9	-0.2	0.6	-0.7	0.1	-0.1	-0.3
Angina	1.5	1.9	4.4	1.4	0.5	-1.3	2.1	1.5	1.6	0.6
Medication for hormone replacement therapy	0.2	0.3	0.5	0.5	-0.7	0.7	0.2	0.3	0.1	-0.6
Vitamin and mineral supplements	1.8	2.5	9.6	-3.1	1.3	-1.1	-1.5	1.2	1.1	-0.3
Supplements: Zinc	0.5	0.6	2.6	0.8	1.6	-0.6	0.6	0.1	-0.1	0.4
Medication: Co-codamol	0.4	0.4	1.2	-0.1	-0.5	0.3	0.6	0.8	0.7	1.1
Medication: Metformin	0.3	0.4	2.2	-1.5	-0.1	-0.3	-0.5	0.4	0.1	0.5
Diabetes (father)	0.2	0.2	0.8	-0.0	0.0	-0.9	0.2	0.3	0.0	-0.6
Diabetes (mother)	0.6	0.8	3.3	-0.6	1.1	0.0	-1.8	-0.4	-0.3	0.6
Severe depression (siblings)	0.3	0.3	0.9	0.3	-0.9	0.1	0.6	0.7	0.5	-0.1
Pack years adult smoking proportion	0.8	1.3	5.2	-2.3	-0.1	1.6	-0.2	0.6	0.5	-0.9
Impedance of leg (right)	0.8	4.0	8.5	2.1	-2.1	2.9	1.9	-0.9	-1.0	2.2
Leg fat-free mass (left)	0.3	1.8	3.3	-1.3	1.7	-1.8	-0.1	1.5	1.5	-0.7
Trunk fat percentage	0.6	2.4	7.7	-0.5	1.0	2.8	0.1	1.9	2.0	-0.2
Hand grip strength (right)	0.4	1.0	4.6	0.2	0.7	-2.1	0.4	-0.8	-0.7	0.5
Townsend deprivation index at recruitment	0.2	0.3	0.9	-0.9	-0.2	0.2	-0.4	-0.2	-0.3	-0.8
Current tobacco smoking	0.5	0.9	1.9	-0.8	1.4	0.2	1.2	-0.9	-0.7	0.8
Average weekly fortified wine intake	2.1	2.5	5.0	-1.3	-1.8	-0.8	-1.7	2.2	2.0	-0.3
Maternal smoking around birth	1.3	1.9	4.9	0.8	2.0	1.2	1.6	0.1	0.3	2.2
Fed-up feelings	1.2	2.2	7.7	0.1	0.3	-0.7	0.9	-2.5	-2.8	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	3.0	-0.3	-0.9	1.7	0.5	-1.0	-1.2	-0.5
Relative age voice broke	1.4	2.2	6.5	-2.3	-0.2	0.3	-0.4	1.3	1.2	-2.5
Taking other prescription medications	1.3	1.9	5.4	2.3	0.0	0.1	0.4	-2.0	-1.9	0.8
Age when periods started (menarche)	0.2	0.4	2.0	0.5	-0.3	-1.4	0.6	-0.1	-0.0	0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	0.6	-1.0	0.9	0.2	1.0	0.9	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.1	-0.1	-0.1	0.8	0.1	0.1	0.8
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.7	0.4	-2.2	0.6	-0.2	-1.9	-1.9	-0.9
Qualifications: CSEs or equivalent	0.6	0.8	2.2	-1.5	1.0	-0.8	0.3	0.7	0.5	-1.0
Serious illness, injury or assault to yourself	0.8	0.9	2.9	1.3	-0.5	0.4	1.7	0.2	0.3	1.2
High blood pressure	0.2	0.5	1.3	0.1	-0.2	1.1	-0.7	-1.0	-0.8	-0.6
Hayfever, allergic rhinitis or eczema	0.7	1.5	7.7	0.3	0.5	-2.8	-1.4	0.2	0.2	-0.4
Multivitamins +/- minerals	1.8	2.3	7.7	2.8	-0.7	1.2	1.8	-1.4	-1.3	0.4
Stomach or abdominal pain in last month	0.3	0.4	1.4	0.2	0.1	1.2	0.2	0.4	0.2	-0.9
Supplements: Glucosamine	1.7	2.2	5.7	0.3	-2.1	2.4	-2.2	0.0	0.0	-0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	-0.8	0.3	0.8	-0.5	-1.0	-1.1	-0.8
Medication: Atenolol	0.7	0.9	3.5	-0.5	-0.6	0.7	-1.0	0.7	0.7	-1.9
Medication: Levothyroxine sodium	0.6	1.0	2.4	-1.1	0.2	1.0	-0.5	-1.1	-1.0	-1.6
Sitting height	0.1	1.0	2.9	-0.4	-1.7	1.2	0.6	1.1	0.9	0.4
Chronic bronchitis/emphysema (father)	0.5	0.6	1.4	-1.2	0.2	-0.6	-0.1	-0.9	-1.1	0.5
High blood pressure (mother)	2.3	3.3	7.4	1.2	-0.7	2.5	1.2	-2.4	-2.7	0.4
Body mass index (BMI)	0.6	2.4	9.2	-0.6	3.0	-1.0	0.0	1.6	1.8	0.2
Impedance of leg (left)	0.7	3.5	10.5	1.4	-2.7	3.2	1.2	-0.8	-1.0	1.2
Leg predicted mass (left)	0.3	1.8	3.2	-1.1	1.8	-1.7	0.0	1.5	1.5	-0.5
Trunk fat mass	0.5	2.1	4.3	-1.0	1.6	1.7	0.1	2.0	2.1	-0.2
Waist circumference	0.6	2.1	5.6	-0.9	1.6	1.1	0.4	2.1	2.4	0.1
Number of incorrect matches in round	0.9	1.5	3.9	-2.0	-1.9	0.5	-0.6	-0.3	-0.3	-1.6
Past tobacco smoking	0.6	1.2	3.7	-0.8	-0.4	1.2	-1.9	-1.0	-1.0	-0.6
Alcohol usually taken with meals	0.2	0.3	1.2	0.4	-0.9	-0.2	1.1	-0.1	0.0	0.2
Nervous feelings	2.0	3.7	8.2	-2.0	-2.8	-0.2	-2.0	-0.9	-1.0	-2.9
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	6.2	-0.3	-2.5	0.7	-0.1	-1.2	-1.3	-0.6
Hearing difficulty/problems with background noise	1.1	1.8	5.0	0.3	-2.2	2.2	-1.0	-0.9	-0.7	-0.6
Hair/balding pattern: Pattern 2	1.4	1.8	5.5	2.3	-2.2	1.1	-0.9	-0.1	-0.1	-0.2
Had menopause	1.6	2.0	5.8	-2.4	-0.1	1.0	-1.5	0.9	0.8	-1.8
Had other major operations	0.3	0.4	0.9	0.7	0.7	0.9	0.3	-0.3	-0.1	0.9
Forced vital capacity (FVC)	0.4	1.4	5.2	1.2	0.5	0.1	1.7	-0.4	-0.3	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	-1.0	0.0	-0.4	0.9	0.7	0.8	-0.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	1.3	-0.5	1.5	1.3	-0.5	-0.6	1.0
Qualifications: None of the above	0.1	0.3	0.9	-0.1	-1.0	-0.2	-0.2	-0.5	-0.6	-0.4
Financial difficulties in last 2 years	1.1	1.5	4.2	2.0	0.5	0.6	1.1	-0.2	-0.3	2.1
Mouth/teeth dental problems	0.4	0.6	1.3	-0.5	-0.8	-1.0	-1.1	0.5	0.7	-0.0
Heart attack	0.2	0.2	1.2	0.1	0.2	-1.1	0.5	0.2	0.1	-0.4
Allergy	0.6	1.3	6.0	-1.3	-1.1	2.5	0.4	0.1	-0.0	0.0
Pain all over the body in last month	0.8	0.9	4.2	-0.0	-2.1	0.3	0.6	0.9	0.7	-0.0
Diabetes (self-reported)	0.7	1.1	2.4	-0.2	-0.5	-1.3	0.2	1.5	1.3	1.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.4	0.2	1.0	-1.5	-1.3	0.1	0.1	-0.1
Medication: Ramipril	0.1	0.1	0.8	0.2	-0.2	-0.9	0.2	-0.2	-0.2	0.3
Medication: Simvastatin	0.1	0.2	0.5	0.3	0.2	-0.7	-0.7	0.2	0.0	-0.4
Fluid intelligence score	0.7	1.5	2.7	0.5	1.5	-1.6	-0.3	-1.4	-1.6	-0.9
Illnesses of siblings	0.6	0.8	2.1	0.0	0.2	0.7	0.4	1.4	1.3	1.0
Neuroticism score	1.4	3.0	8.5	-0.7	-1.1	0.4	-0.3	-2.5	-2.9	-2.1
Weight	0.5	2.3	5.5	-0.8	2.0	-0.7	0.3	2.2	2.3	0.1
Impedance of arm (right)	1.2	5.6	27.5	0.8	-3.3	5.2	-0.7	-0.0	-0.3	-0.3
Arm fat percentage (right)	0.5	2.1	4.2	-0.9	2.0	1.6	-0.4	1.8	2.0	-0.2
Trunk fat-free mass	0.7	3.9	13.5	-1.9	2.1	-3.7	-0.2	1.6	1.7	-0.4
Hip circumference	0.5	2.3	5.2	-1.7	2.3	-0.7	-1.0	1.7	1.8	-0.4
Time employed in main current job	1.1	1.3	4.0	-0.2	-0.9	1.1	0.6	-1.2	-1.0	-2.0
Alcohol intake versus 10 years previously	0.3	0.5	1.6	-1.3	1.1	-0.1	-0.7	0.2	0.3	0.0
Father’s age at death	0.1	0.1	0.7	-0.2	0.4	-0.1	-0.4	-0.1	-0.2	-0.8
Worrier / anxious feelings	1.7	3.1	6.9	-0.8	-1.3	0.8	-1.0	-2.3	-2.6	-2.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.1	0.4	-0.3	0.2	0.7	-1.4	-1.8	-0.1
Falls in the last year	0.2	0.3	1.0	0.1	-0.7	1.0	0.2	0.7	0.6	0.1
Hair/balding pattern: Pattern 3	1.9	2.8	6.7	-0.4	2.6	-2.0	2.3	-1.2	-1.3	0.5
Number of live births	0.2	0.2	1.3	0.5	-0.2	0.2	-1.2	-0.2	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	10.3	1.9	-0.1	0.4	1.8	1.3	1.5	3.2
Pulse rate	0.8	1.3	2.7	-1.4	0.1	0.5	-0.8	1.3	1.3	1.6
Happiness	1.8	2.2	6.6	1.2	0.6	-0.8	-0.3	-2.6	-2.5	0.2
Noisy workplace	1.4	1.7	6.0	2.5	-1.4	-0.7	-0.8	-1.1	-0.8	0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.3	5.6	2.4	-0.6	1.1	0.2	0.2	0.5	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.3	1.4	-1.0	-1.4	-0.9	-1.5	-1.5	0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.5	-0.0	-0.7	-1.2	0.1	0.1	-0.1	-0.0
Asthma	0.6	1.2	3.9	0.5	2.0	-1.8	0.2	-0.9	-0.7	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	5.9	-0.7	0.6	1.2	-0.3	-2.1	-2.4	-0.4
Medication: Cholesterol lowering	0.4	0.6	2.5	0.5	-1.6	-0.5	0.7	-0.7	-0.8	-0.0
Depression (self-reported)	0.2	0.3	1.1	0.1	1.1	0.5	-0.3	0.3	0.1	0.4
Medication: Lansoprazole	3.0	3.4	8.9	2.3	-0.4	1.1	0.6	-3.0	-2.8	0.5
Prospective memory result	0.4	0.5	1.4	-0.2	0.3	0.5	1.1	0.2	0.4	1.2
Lung cancer (father)	0.4	0.5	1.5	0.1	0.2	0.4	1.2	0.5	0.5	1.0
Illnesses of mother	1.5	1.8	6.3	-0.6	0.3	-0.3	0.1	2.4	2.5	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	4.7	1.0	-0.6	1.0	0.9	1.6	1.8	2.2
Pulse wave Arterial Stiffness index	0.8	0.9	2.8	-0.9	1.7	0.2	1.7	0.2	0.2	0.4
Impedance of arm (left)	1.5	6.9	34.6	0.8	-3.6	5.9	-0.3	-0.0	-0.3	0.0
Arm fat mass (right)	0.5	2.1	5.6	-0.9	2.4	0.3	0.0	1.9	2.1	0.1
Trunk predicted mass	0.7	3.8	14.0	-1.9	2.1	-3.7	-0.2	1.5	1.6	-0.4
Standing height	0.1	1.2	2.7	-0.9	-1.6	0.3	0.6	1.6	1.4	-0.4
Length of working week for main job	0.3	0.3	1.3	-0.8	0.1	0.5	0.0	-0.2	-0.2	-1.1
Exposure to tobacco smoke at home	2.5	2.8	5.8	1.2	1.8	0.7	1.3	-2.4	-2.1	1.8
Breastfed as a baby	1.0	1.3	3.5	-1.9	0.5	1.1	-1.5	0.5	0.4	-1.3
Tense / ‘highly strung’	1.6	2.6	4.8	0.1	-2.2	1.7	-0.7	-1.5	-1.9	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	5.4	-1.0	1.2	1.8	-0.8	-2.3	-2.3	-1.2
Hair/balding pattern: Pattern 4	1.2	3.0	6.2	2.2	1.2	0.7	2.5	-2.1	-1.9	0.2
Birth weight of first child	0.2	0.3	0.9	-0.8	-0.5	-0.9	0.3	-0.1	0.1	-0.6
Peak expiratory flow (PEF)	0.7	1.6	5.7	1.3	-0.6	-0.1	0.8	1.1	1.2	2.4
Pulse wave reflection index	0.7	0.9	3.3	0.1	1.5	0.3	1.8	0.3	0.6	0.3
Ever highly irritable/argumentative for 2 days	2.1	2.5	8.1	-0.6	0.7	0.6	-0.4	-2.5	-2.8	-1.3
Loud music exposure frequency	0.7	0.7	1.4	0.3	-1.2	-0.9	0.3	-1.0	-1.2	-0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.7	1.1	0.5	-0.3	0.3	1.3	1.0	0.5
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	5.9	0.9	-0.3	2.4	1.2	-1.6	-1.7	1.0
Blood clot in the leg (DVT)	1.2	1.5	4.6	2.1	1.4	-0.5	1.7	0.4	0.7	0.8
Medication: Paracetamol	0.2	0.4	1.4	-0.1	0.6	-1.2	0.5	-0.6	-0.4	-0.4
Headache pain in last month	0.2	0.3	1.3	0.2	-0.0	-0.2	-0.5	-1.1	-0.9	0.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.5	-0.1	0.9	-0.1	-0.8	-1.2	-1.1	0.7
Glaucoma (self-reported)	0.8	1.0	3.4	0.1	-0.7	1.7	-0.4	-0.1	0.0	1.8
Gout (self-reported)	0.5	0.6	1.5	-0.4	0.5	-0.5	0.9	1.0	1.2	0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.4	-0.5	-0.5	1.6	-0.1	-0.8	-0.5	-0.5
Medication: Amlodipine	0.5	0.7	2.0	-0.4	1.2	-0.8	-0.8	-0.3	0.0	-1.4
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.4	0.0	0.4	-1.5	1.3	0.0	0.1	0.6
Birth weight	1.2	2.6	6.8	-2.6	0.3	-1.6	-2.3	0.3	0.2	-1.9
Chronic bronchitis/emphysema (mother)	0.8	1.0	4.3	0.5	-0.9	2.1	0.1	-0.2	-0.1	1.2
High blood pressure (siblings)	1.5	2.2	6.7	0.1	1.1	-0.1	0.1	-2.6	-2.5	-1.0
Forced vital capacity (FVC), Best measure	0.1	0.2	1.1	-0.0	-0.2	0.6	0.3	-0.1	-0.1	1.1
Body fat percentage	0.4	1.7	5.0	-0.2	1.4	2.2	0.3	1.5	1.6	0.2
Leg fat percentage (right)	0.5	1.7	4.3	0.6	2.1	1.1	1.1	0.9	1.1	1.6
Arm fat-free mass (right)	0.6	3.2	11.0	-1.4	2.0	-3.3	0.2	1.6	1.7	-0.1
Exposure to tobacco smoke outside home	1.9	2.5	6.6	0.5	1.7	-0.5	0.7	-2.6	-2.5	1.0
Comparative body size at age 10	1.4	3.8	11.0	-1.8	3.3	1.6	-1.5	-1.3	-1.6	-1.9
Number of full brothers	1.2	1.6	3.8	1.8	-0.8	-0.9	1.6	-0.1	0.1	2.0
Worry too long after embarrassment	1.4	2.4	5.6	-1.8	-0.6	2.3	-0.8	-0.7	-1.3	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	6.0	-0.2	0.5	1.4	-0.8	-2.5	-2.4	-0.1
Wheeze or whistling in the chest in last year	1.5	2.8	7.2	1.0	0.4	1.2	1.2	-2.7	-2.4	1.4
Number of children fathered	1.5	1.7	3.0	0.9	-0.8	-1.3	1.5	1.6	1.7	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.2	-0.4	0.0	-0.4	0.1	0.5	-0.2
Age at first live birth	0.3	0.5	2.2	0.3	0.5	0.8	0.1	0.5	0.5	1.5
Pulse wave peak to peak time	0.9	1.0	3.1	0.9	-1.8	-0.2	-1.6	-0.4	-0.5	-0.5
Health satisfaction	0.7	1.0	2.0	1.0	1.3	0.5	0.1	-1.4	-1.4	-0.3
Shortness of breath walking on level ground	2.0	2.3	7.6	2.8	0.6	0.5	1.4	-1.6	-1.2	1.6
Qualifications: College or University degree	0.3	1.1	2.5	0.4	0.9	0.7	-1.6	1.1	1.3	1.0
Eye problems/disorders: None of the above	0.9	1.0	2.4	-0.5	-0.7	-1.2	-0.3	1.0	1.1	-1.5
Mouth/teeth dental problems: Loose teeth	0.7	0.9	3.2	-0.3	0.4	1.8	0.9	-0.9	-1.0	-0.1
Emphysema/chronic bronchitis	1.9	2.2	5.2	0.9	-2.3	1.9	1.7	1.4	1.0	0.4
Medication for pain relief, constipation, heartburn	0.6	1.1	3.2	-0.9	0.1	-0.5	-0.5	1.7	1.8	0.6
Neck or shoulder pain in last month	0.9	1.3	3.0	-0.6	1.7	-0.5	0.1	-1.6	-1.5	-0.5
Medication: Blood pressure	0.8	1.4	3.7	0.1	-0.5	0.6	0.3	1.9	1.9	-1.2
Angina (self-reported)	1.3	1.7	3.2	1.4	0.6	-1.4	1.8	1.4	1.5	0.3
Migraine (self-reported)	0.5	0.6	3.0	-1.7	0.0	-0.9	-0.5	-0.1	-0.3	-0.5
Medication: Ibuprofen	1.4	1.7	5.7	-0.3	0.1	1.0	-0.4	-2.1	-2.4	-0.8
Medication: Allopurinol	0.4	0.6	2.4	0.3	-1.6	0.4	1.0	0.2	0.4	-0.2
Medication: Omeprazole	0.8	1.0	4.8	2.2	0.0	0.1	1.3	0.0	0.2	0.4
Medication: Seretide 50 evohaler	0.9	1.0	2.2	1.4	0.8	-0.0	-0.0	-1.5	-1.4	-0.8
Mean time to correctly identify matches	0.3	0.6	1.7	-0.8	-0.6	0.5	-0.5	0.7	0.8	-1.3
Heart disease (mother)	0.5	0.6	1.2	1.1	-0.4	-0.6	0.9	-0.8	-0.9	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	6.1	-0.8	-1.9	-2.5	-1.5	0.0	-0.0	-0.4
Whole body fat mass	0.4	1.8	3.8	-0.8	1.9	1.1	0.3	1.8	1.9	0.0
Leg fat mass (right)	0.5	1.9	5.4	-0.2	2.3	0.3	1.1	1.6	1.8	0.9
Arm predicted mass (right)	0.7	3.7	10.8	-1.7	2.1	-3.3	0.2	1.9	2.0	-0.1
Pulse rate, automated reading	1.0	3.2	6.2	-2.5	0.5	1.3	-1.9	2.3	2.4	0.1
Alcohol intake frequency.	0.4	0.9	3.3	-0.2	1.8	-1.1	0.7	-0.8	-0.5	0.7
Comparative height size at age 10	0.2	1.2	3.2	-0.3	-0.7	1.0	0.8	1.7	1.8	0.2
Number of full sisters	0.4	0.5	1.6	-0.4	0.6	-0.5	1.3	-0.3	-0.3	-0.9
Suffer from ‘nerves’	1.3	2.0	7.7	-0.5	-2.3	0.3	-0.3	-0.5	-0.7	-2.8
Overall health rating	0.4	0.9	2.6	-0.3	1.6	0.5	0.1	-0.9	-1.2	-1.0
Chest pain or discomfort	0.4	0.6	1.8	0.2	-0.3	1.3	-0.0	-1.2	-1.0	-0.5
Had major operations	0.4	0.5	1.1	0.6	-0.2	1.0	0.3	-1.1	-0.9	-0.3
Age at last live birth	0.9	1.4	6.8	0.7	-0.7	2.6	0.5	-0.3	-0.3	1.1
Family relationship satisfaction	0.2	0.3	1.3	0.4	0.3	-0.4	-0.1	-0.4	-0.5	1.1
Leg pain on walking	0.3	0.4	2.0	1.4	0.3	-0.1	0.5	0.1	0.1	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.5	1.4	1.0	0.6	1.6	-0.4	-0.5	0.2
Commuting to job workplace: Car/motor vehicle	2.8	3.3	6.7	1.7	1.3	1.1	1.1	-2.5	-2.6	1.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.6	-0.9	0.2	1.6	0.3	-0.1	0.1	-0.6
Medication: Aspirin	0.3	0.4	1.2	0.4	-0.6	0.4	-0.9	-0.1	-0.3	-1.1
Supplements: Vitamin C	0.5	0.6	2.9	1.7	-0.1	-0.2	0.9	-0.4	-0.5	-0.1
Knee pain experienced in last month	0.4	0.6	1.4	0.5	-0.8	-1.0	0.6	-1.2	-0.9	0.1
Hypertension (Self-reported)	0.2	0.6	1.1	0.4	-0.4	1.1	-0.6	-0.9	-0.7	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	6.9	1.5	1.1	1.5	1.1	-2.6	-2.2	0.3
Illnesses of father: Heart disease	0.5	0.7	2.2	0.8	0.4	-0.4	0.2	-1.2	-1.5	0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.3	-0.5	0.2	0.1	-0.1	0.1	-0.6
Smoking status: Previous	0.9	1.4	3.3	1.4	-0.3	-1.8	1.6	0.9	0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.8	0.2	-1.0	2.2	2.0	0.6	0.4	0.2
Whole body fat-free mass	0.5	3.0	9.4	-1.7	1.9	-3.1	-0.2	1.6	1.6	-0.6
Leg fat-free mass (right)	0.4	2.2	3.3	-1.8	1.3	-1.7	-0.5	1.6	1.6	-1.3
Arm fat percentage (left)	0.5	2.0	4.5	-0.7	2.1	1.9	-0.1	1.6	1.7	0.0
Average weekly red wine intake	2.6	3.8	5.1	2.1	2.2	0.7	2.2	-2.2	-2.0	1.8
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.4	-0.9	-0.7	-1.0	-1.6	1.5	1.4	-1.2
Mood swings	1.0	1.7	3.9	-1.3	1.4	-0.7	-0.0	-1.7	-2.0	-1.1
Loneliness, isolation	0.4	0.5	1.6	0.2	0.0	1.1	0.4	-0.8	-1.2	0.2
Long-standing illness, disability or infirmity	0.4	0.6	1.8	-0.0	-0.0	1.0	0.0	-1.3	-1.3	-0.1
Ever had bowel cancer screening	0.9	1.0	2.2	-1.1	-0.3	1.4	-1.2	0.3	0.4	-1.5
Diabetes diagnosed by doctor	0.6	1.0	3.0	-0.7	-1.0	-0.6	-0.4	1.7	1.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.2	-1.0	0.8	-0.6	-1.1	0.4	0.5	0.8
Friendships satisfaction	0.3	0.4	1.6	-0.3	0.0	1.3	-0.5	0.6	0.4	0.1
Qualifications: nursing, teaching	0.7	1.1	3.8	1.7	0.8	-0.4	-0.4	0.4	0.5	1.9
Commuting to job workplace: Walk	2.4	2.5	5.3	-1.6	0.4	-0.1	-2.3	2.1	1.8	-1.4
Eye problems/disorders: Cataract	1.6	1.9	3.7	1.2	1.9	1.1	1.5	-1.4	-1.2	1.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.8	0.5	0.7	0.9	0.9	0.0	0.1	0.7
Medication for cholesterol	0.5	0.7	3.1	-1.8	-0.6	-0.0	-0.4	0.7	0.7	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.6	1.3	0.4	0.7	1.2	-0.9	-1.0	0.2
Back pain experienced in last month	0.7	1.0	1.8	-1.0	0.2	0.8	-1.2	-1.3	-1.3	-0.7
Mineral and other dietary supplements	0.8	1.1	2.9	-0.6	1.5	-1.7	1.0	0.6	0.5	0.7
Breast cancer (self-reported)	1.0	1.2	6.1	-0.1	1.2	0.1	2.5	-0.1	0.4	0.9
Asthma (self-reported)	0.6	1.1	3.7	0.5	1.9	-1.7	-0.1	-0.8	-0.5	0.0
Osteoporosis (self-reported)	1.0	1.2	4.0	-1.4	-2.0	1.2	-0.8	0.5	0.4	-0.5
Osteoarthritis (self-reported)	0.6	0.8	1.7	-0.7	-1.2	0.2	0.3	1.2	1.3	-0.2
Medication: Aspirin	0.7	0.8	1.2	1.1	-1.1	1.0	-0.4	-0.7	-0.9	-1.0
Medication: Gliclazide	1.0	1.2	2.2	0.8	1.2	-0.9	0.7	-1.1	-1.2	1.5
Illnesses of father: None of the above (group 1)	0.3	0.3	0.9	-0.2	0.0	0.9	-0.2	0.7	0.9	-0.4
Smoking status: Current	0.5	0.7	1.9	-1.1	1.4	0.2	0.9	-0.7	-0.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.8	0.3	-0.7	0.4	-0.8	1.5	1.7	0.8
Whole body water mass	0.6	3.2	9.1	-1.8	2.1	-3.0	-0.2	1.6	1.6	-0.6
Leg predicted mass (right)	0.4	2.1	3.1	-1.8	1.4	-1.7	-0.5	1.6	1.6	-1.2
Arm fat mass (left)	0.5	2.1	6.0	-0.9	2.4	0.0	0.3	1.9	2.1	0.2
Number of self-reported non-cancer illnesses	1.1	1.8	5.7	1.3	0.6	0.1	-0.1	-2.4	-2.2	-0.3
Average weekly champagne plus white wine intake	0.9	1.2	3.5	-0.3	-0.7	1.9	-1.0	1.1	1.0	-1.0
Miserableness	0.8	1.4	4.6	-0.5	-0.7	0.7	-0.0	-1.6	-2.1	-1.2
Guilty feelings	2.0	3.0	6.8	-1.6	1.7	-0.6	0.3	-2.4	-2.6	-1.6
Wears glasses or contact lenses	0.1	0.1	0.3	-0.4	0.1	0.6	-0.2	0.3	0.5	-0.4
Ever taken oral contraceptive pill	0.9	1.0	4.0	0.7	-0.3	-1.0	2.0	0.1	0.1	1.1
Hearing aid user	1.4	1.5	3.3	1.8	-0.6	0.6	1.8	-0.5	-0.3	1.8
Mother’s age at death	2.1	2.6	10.2	-1.6	-3.2	0.1	-1.1	1.3	1.1	-1.3
Financial situation satisfaction	0.4	0.5	1.8	0.6	0.9	1.4	-0.1	-0.7	-0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.0	0.1	1.4	-1.3	0.1	-1.2	-0.9	0.3
Commuting to job workplace: Public transport	0.7	0.8	3.1	-0.7	-1.8	0.4	0.6	1.0	0.9	0.3
Eye problems/disorders: Glaucoma	0.7	0.8	2.5	-1.0	-0.7	0.3	-1.6	0.6	0.7	1.0
Medication: Blood pressure	1.1	2.2	5.8	1.6	0.4	0.7	-1.0	-2.4	-2.3	0.0
Pain type(s) experienced in last month: Hip pain	0.8	0.9	2.9	-1.7	1.6	-0.8	-0.5	-0.1	0.1	-0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.9	1.1	-1.3	1.7	-0.7	-0.9	-0.9	-0.6
High cholesterol (Self-reported)	0.4	0.6	1.2	0.8	-0.5	-1.1	1.0	-0.1	-0.3	1.1
Medication: Bendroflumethiazide	0.7	1.1	6.3	0.4	2.5	0.3	0.7	-0.3	-0.0	-0.6
Medication: Paracetamol	0.3	0.4	0.9	0.6	0.4	-0.6	0.5	-0.7	-0.6	-0.9
Medication: Lisinopril	0.5	0.6	2.5	0.1	1.6	0.9	-0.5	0.2	0.3	-0.7
Medication: Atorvastatin	2.4	3.0	11.2	2.0	-0.1	-0.0	3.3	0.1	0.0	2.4
Illnesses of father: High blood pressure	0.8	1.0	3.1	-0.6	0.5	0.0	-1.8	-1.3	-1.3	-0.4
Alcohol drinker status: Never	0.3	0.4	1.0	0.6	0.2	-0.2	1.0	0.6	0.8	0.6
Ever smoked	0.3	0.5	1.7	0.6	0.4	0.2	1.3	0.6	0.8	0.1
Basal metabolic rate	0.5	2.8	6.4	-1.5	2.1	-2.5	0.1	1.7	1.8	-0.4
Leg fat percentage (left)	0.3	1.0	3.2	0.2	1.8	1.2	0.6	0.8	1.0	0.7
Arm fat-free mass (left)	0.7	3.6	10.3	-1.4	2.4	-3.2	-0.0	1.9	1.9	-0.2
Number of operations (self-reported)	0.4	0.5	1.7	1.3	1.1	0.1	0.6	-0.6	-0.4	0.1
Average weekly beer plus cider intake	1.6	2.3	4.9	-2.1	-1.5	-0.0	-2.0	-0.1	-0.5	-2.2
Irritability	0.4	0.6	2.1	-0.7	-0.6	-1.4	-0.4	-0.6	-0.9	0.5
Risk taking	0.7	1.0	3.6	-0.8	1.9	0.1	1.1	-0.6	-0.9	0.6
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.6	1.2	-1.1	-0.3	-0.1	-0.6	-0.4	-1.1
Fractured/broken bones in last 5 years	0.4	0.5	1.4	-0.4	-0.4	1.2	-0.0	-0.4	-0.3	1.1
Age started oral contraceptive pill	0.3	0.4	1.0	0.2	-0.8	-0.4	0.0	1.0	1.0	-0.3
Diastolic blood pressure, automated reading	0.5	1.7	6.5	-2.1	0.6	0.4	-2.6	-0.0	0.1	-0.4
Ever depressed for a whole week	1.0	1.3	6.5	-0.9	-0.6	2.5	0.6	-0.5	-0.7	0.0
Unable to work because of sickness or disability	0.3	0.3	1.2	0.6	-1.1	0.1	-0.3	-0.4	-0.3	0.7
Commuting to job workplace: Cycle	1.6	1.9	4.3	-0.7	0.9	-1.2	-0.4	2.0	2.1	1.5
Myopia	1.3	1.9	3.6	0.7	-0.4	1.5	1.6	1.9	1.8	1.1
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.7	-0.2	-0.1	-0.7	0.8	0.8	0.7	0.8
Cholesterol lowering medication	1.0	1.5	5.0	2.2	0.5	-0.6	0.9	0.6	0.6	1.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	3.0	1.7	-0.4	-0.4	1.2	0.6	0.7	0.1
Pain experienced in last month	1.4	2.3	7.2	1.0	0.3	0.9	1.2	1.7	1.7	2.7
Supplements: Calcium	0.6	0.6	2.6	0.4	0.3	0.8	0.9	-0.1	0.1	1.6
Basal cell carcinoma (self-reported)	1.3	1.5	2.8	1.7	-0.4	0.8	0.9	-1.4	-1.6	1.1
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.9	0.5	-0.1	-1.0	0.8	0.3	0.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	4.2	2.0	1.0	-0.7	1.6	0.2	0.5	0.7
Heart disease (siblings)	0.3	0.3	1.4	-0.7	-1.2	-0.2	-0.4	-0.0	0.1	0.1
Alcohol drinker status: Previous	0.7	0.8	1.5	-1.1	1.0	-0.9	-0.2	-1.2	-1.2	0.2
Pack years of smoking	1.1	1.7	6.9	-2.6	-0.2	1.4	-0.4	0.7	0.6	-1.2
Impedance of whole body	1.2	6.0	26.9	1.5	-3.3	5.2	0.7	-0.6	-0.8	0.9
Leg fat mass (left)	0.4	1.5	4.2	-0.5	2.1	0.4	0.7	1.5	1.6	0.4
Arm predicted mass (left)	0.7	3.7	12.0	-1.6	2.3	-3.5	-0.2	1.7	1.8	-0.4