TWAS hub - NRXN3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0794	0.0252	0.00130	0.034	0.022	0.022	0.03	0.036	3.3e-05	0.00068	0.00072	8.4e-05	1.6e-05
2	TCGA	Esophageal Carcinoma	0.2900	0.0980	0.00450	-0.006	0.023	-0.001	NA	0.016	5.7e-01	0.06300	0.36000	NA	9.8e-02
3	TCGA	Prostate Adenocarcinoma	0.0927	0.0318	0.00095	0.051	0.006	0.023	NA	0.039	4.7e-06	0.06800	0.00150	NA	5.6e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Body Mass Index (BMI) (2010)	7.3	10.0	15.7	-0.2	4.0	3.8
BMI	5.7	33.3	60.9	1.2	7.8	6.1
Current tobacco smoking	5.2	8.5	17.7	-1.7	-2.3	-4.2
Smoking status: Current	5.1	8.1	15.4	-2.0	-2.2	-3.9
Smoking Status	4.8	11.4	15.4	-2.3	-3.7	-3.9
Supplements: Fish oil (including cod liver oil)	4.5	5.9	12.5	1.5	-3.5	-1.7
Type 2 Diabetes (T2D) (2018)	4.4	8.3	21.3	-0.7	4.6	1.8
Leg fat mass (right)	4.3	16.6	29.2	0.6	5.4	4.5
Medication for hormone replacement therapy	4.1	4.6	9.8	1.1	-3.1	-1.7
Medication: Lisinopril	4.1	5.3	9.7	-2.4	3.1	0.6
Leg fat mass (left)	4.1	15.9	25.9	0.8	5.1	4.6
Medication: Allopurinol	4.0	5.4	12.2	1.5	1.3	3.5
Whole body fat mass	4.0	16.7	26.4	0.6	5.1	4.8
Trunk fat mass	3.7	16.1	26.6	0.7	5.2	4.6
Arm fat mass (right)	3.7	15.2	23.4	1.4	4.8	4.5
Arm fat percentage (left)	3.7	14.7	24.2	0.8	4.4	4.9
Arm fat mass (left)	3.7	15.0	22.1	1.4	4.7	4.6
Ever highly irritable/argumentative for 2 days	3.6	4.3	8.5	-1.3	-1.7	-2.9
Mouth/teeth dental problems: Bleeding gums	3.6	4.7	8.8	-2.3	0.2	3.0
Number of children fathered	3.6	4.1	8.8	-1.8	-0.6	-3.0
Weight	3.4	16.5	25.4	2.0	5.0	4.5
Arm fat percentage (right)	3.4	13.6	21.3	1.0	4.3	4.6
Body fat percentage	3.4	13.4	22.3	0.3	4.7	4.2
Average weekly red wine intake	3.4	5.0	12.4	0.6	-3.5	1.5
Hearing aid user	3.4	3.9	5.7	1.8	-1.6	-2.4
Diabetes (mother)	3.3	4.2	6.3	-2.5	2.5	-0.3
Trunk fat percentage	3.3	13.2	23.8	0.0	4.9	4.0
Body mass index (BMI)	3.3	14.3	21.6	1.8	4.2	4.6
Leg fat percentage (right)	3.3	12.0	23.7	0.4	4.9	3.5
Qualifications: NVQ or HND or HNC or equivalent	3.3	4.0	8.2	1.7	-0.9	-2.9
Leg fat percentage (left)	3.3	11.8	21.0	0.6	4.6	3.7
Type 2 Diabetes (T2D) (2012)	3.2	3.7	5.4	-1.2	2.3	2.1
Waist circumference	2.9	10.7	16.1	1.4	3.7	4.0
Hair/balding pattern: Pattern 2	2.9	3.7	8.2	-0.8	-1.5	-2.9
Number of live births	2.9	4.1	9.4	-0.2	-1.7	-3.1
Hip circumference	2.7	11.4	18.1	2.2	4.3	3.4
Falls in the last year	2.7	3.6	6.8	1.8	-2.6	-1.0
Emphysema/chronic bronchitis	2.7	3.1	4.4	-1.9	-1.2	-2.1
Serious illness, injury or assault to yourself	2.6	3.2	8.2	-2.9	0.5	-1.1
Mineral and other dietary supplements	2.5	3.4	7.8	-1.1	2.8	1.1
Gout (self-reported)	2.3	3.2	6.2	1.2	1.4	2.5
Leg fat-free mass (left)	2.2	11.6	15.0	2.4	3.9	3.7
Supplements: Glucosamine	2.2	2.9	4.5	2.0	-2.1	0.0
Chronic bronchitis/emphysema (father)	2.2	2.6	3.9	-0.2	-2.0	-2.0
Leg predicted mass (left)	2.2	11.7	15.2	2.4	3.9	3.8
Financial situation satisfaction	2.2	2.7	8.1	0.3	-2.9	0.0
Fractured/broken bones in last 5 years	2.1	2.8	8.0	-2.8	-0.4	0.3
Schizophrenia (2014)	2.0	4.3	10.6	3.3	0.1	1.6
Medication: Metformin	2.0	2.8	4.9	-0.7	2.2	1.8
Length of working week for main job	2.0	2.3	3.4	-1.5	1.8	1.1
Hair/balding pattern: Pattern 4	2.0	4.8	9.4	1.4	1.7	3.1
Leg fat-free mass (right)	2.0	10.7	13.9	2.5	3.4	3.7
Leg predicted mass (right)	2.0	10.6	13.5	2.6	3.4	3.7
Alzheimer’s Disease (in mother)	1.9	2.2	5.9	2.4	-0.8	-0.1
Diabetes (self-reported)	1.9	3.0	7.3	-0.3	2.7	1.2
Hair/balding pattern: Pattern 3	1.9	2.8	8.2	-0.4	0.2	2.9
Commuting to job workplace: Car/motor vehicle	1.9	2.2	5.5	1.0	-0.3	2.3
Osteoarthritis (self-reported)	1.9	2.4	4.8	1.0	-1.2	-2.2
Basal metabolic rate	1.9	10.4	14.6	2.5	3.8	3.2
Bipolar Disorder (2018)	1.8	2.9	4.3	2.1	-1.8	1.1
HDL Cholesterol	1.8	2.9	4.9	0.6	-1.9	-2.2
Mouth/teeth dental problems: Dentures	1.8	3.0	7.6	-1.1	-0.2	-2.8
Diabetes diagnosed by doctor	1.8	3.0	7.9	0.1	2.8	1.0
Number of operations (self-reported)	1.8	2.7	5.7	-2.4	-0.8	-1.3
Average weekly spirits intake	1.7	2.1	5.0	-1.2	0.2	-2.2
Neck or shoulder pain in last month	1.7	2.5	6.4	-0.2	-2.5	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.1	3.8	-0.7	-1.4	-2.0
Medication: Gliclazide	1.7	1.9	2.8	0.3	1.6	1.7
Supplements: Calcium	1.7	1.9	3.8	-0.9	-1.1	-1.9
Bipolar Disorder or Schizophrenia	1.6	3.9	10.3	3.2	-0.5	1.0
Alzheimer’s Disease (in father)	1.6	1.7	3.9	0.4	1.0	2.0
Impedance of leg (right)	1.6	7.9	13.1	-3.3	-0.3	-3.6
Medication: Cholesterol lowering	1.6	2.5	2.9	-1.6	1.4	1.7
Medication: Lansoprazole	1.6	1.8	3.1	-1.2	1.8	-0.9
Health satisfaction	1.6	2.0	2.8	-1.6	-0.9	1.7
Alcohol intake frequency.	1.6	3.6	6.8	2.6	1.9	-0.8
Eye problems/disorders: Glaucoma	1.6	1.9	3.8	-1.9	1.2	0.7
Lung FEV1/FVC ratio	1.5	7.5	18.8	1.7	1.0	4.3
Illnesses of mother	1.5	1.9	3.5	0.0	-1.5	-1.9
Whole body fat-free mass	1.5	8.5	10.7	2.6	3.3	2.8
Qualifications: nursing, teaching	1.5	2.3	5.0	-0.2	-1.3	-2.2
Major Depression (MDD)	1.4	1.7	4.8	0.1	-0.5	-2.2
Mean Putamen Volume	1.4	1.6	2.0	1.4	-1.4	0.8
Multivitamins +/- minerals	1.4	1.8	4.1	0.9	-2.0	-0.7
Impedance of leg (left)	1.4	6.8	11.3	-3.0	-0.5	-3.4
Fluid intelligence score	1.4	2.8	7.3	1.0	-0.4	2.7
Exposure to tobacco smoke at home	1.4	1.6	2.6	-0.3	1.4	1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.8	-0.3	2.0	1.0
Arm predicted mass (right)	1.4	7.3	10.7	2.4	3.3	2.3
Had major operations	1.4	1.6	4.2	-2.1	-0.4	0.7
Whole body water mass	1.4	8.2	9.7	2.7	3.1	2.8
Alcohol drinker status: Never	1.4	1.7	4.6	2.1	0.1	0.6
Arm fat-free mass (left)	1.4	7.3	10.9	2.5	3.3	2.2
Impedance of whole body	1.4	7.1	11.9	-3.5	-0.6	-3.0
Arm predicted mass (left)	1.4	7.3	10.5	2.5	3.2	2.2
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.6	-1.2	-0.1	-1.9
Average weekly fortified wine intake	1.3	1.5	2.2	1.5	-1.0	-1.1
Stomach or abdominal pain in last month	1.3	1.6	3.6	1.0	0.4	1.9
Alcohol usually taken with meals	1.3	2.1	5.1	1.0	0.2	2.3
Hearing difficulty/problems with background noise	1.3	2.2	6.3	-0.4	-0.2	2.5
Arm fat-free mass (right)	1.3	6.5	8.9	2.3	3.0	2.4
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.1	-1.2	0.9	1.5
Schizophrenia vs Biploar Disorder	1.2	1.6	3.5	1.9	0.9	0.5
Pack years adult smoking proportion	1.2	1.8	2.6	1.4	-1.6	-0.9
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	3.5	0.1	-1.9	-0.9
Trunk fat-free mass	1.2	6.8	8.6	2.7	2.9	2.1
Alcohol intake versus 10 years previously	1.2	1.8	4.9	0.6	2.2	0.0
Trunk predicted mass	1.2	7.0	8.8	2.8	3.0	2.2
Birth weight of first child	1.2	2.2	3.2	1.8	0.7	1.7
Glaucoma (self-reported)	1.2	1.4	2.2	-1.5	0.4	1.3
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.2	0.6	-0.8	-1.8
Alcohol drinker status: Previous	1.2	1.4	3.7	1.9	0.5	-0.4
Schizophrenia (2018)	1.1	2.3	6.0	2.4	0.8	0.5
Pulse wave reflection index	1.1	1.4	2.9	-1.1	0.3	-1.7
Medication: Ibuprofen	1.1	1.3	1.9	0.5	-1.4	-1.4
Ever taken oral contraceptive pill	1.1	1.2	2.3	0.7	1.5	-0.9
Pack years of smoking	1.1	1.6	2.4	1.5	-1.5	-0.3
Prostate Cancer	1.0	1.4	2.2	-1.5	1.2	-0.8
Neuroticism (2016)	1.0	1.5	3.3	1.0	-1.8	0.4
Maternal smoking around birth	1.0	1.5	2.6	-0.5	-1.2	-1.6
Financial difficulties in last 2 years	1.0	1.4	3.6	0.5	-1.9	-0.4
Prospective memory result	1.0	1.2	3.2	0.2	-0.6	-1.8
Peak expiratory flow (PEF)	1.0	2.3	5.0	-0.1	2.2	1.4
Angina (self-reported)	1.0	1.3	2.9	1.7	-0.1	1.0
Age at last live birth	1.0	1.5	2.5	-1.1	0.8	1.6
Illnesses of father: Heart disease	1.0	1.4	2.8	1.7	-0.7	1.0
Medication: Blood pressure	1.0	1.9	4.1	1.3	2.0	0.3
Pain experienced in last month	1.0	1.7	3.6	-1.9	1.3	-0.2
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.2	-0.7	1.2	2.0
Age at First Birth	0.9	1.3	2.8	0.3	1.0	1.7
Angina	0.9	1.2	2.4	1.5	0.1	1.1
Age when periods started (menarche)	0.9	2.1	5.6	-2.4	0.8	0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	1.7	-1.0	-0.7	-1.3
Lung cancer (father)	0.9	1.0	1.4	0.7	-1.0	-1.2
Medication: Paracetamol	0.9	1.4	2.9	-0.3	-1.2	-1.7
Headache pain in last month	0.9	1.5	3.8	1.9	-0.6	0.6
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	2.3	1.5	-0.8	-1.2
High blood pressure (siblings)	0.9	1.3	2.9	-0.1	1.1	1.7
Age at first live birth	0.9	1.6	3.8	-0.7	0.7	1.9
Mean time to correctly identify matches	0.9	1.7	4.1	-2.0	0.6	0.7
Heart disease (mother)	0.9	1.1	2.7	-0.3	0.7	1.6
Pulse rate, automated reading	0.9	3.0	6.8	-1.4	2.6	0.5
Suffer from ‘nerves’	0.9	1.4	3.6	1.9	-0.6	0.6
Knee pain experienced in last month	0.9	1.4	2.1	1.4	-1.4	-0.4
Commuting to job workplace: Walk	0.9	1.0	1.6	-0.2	-1.3	-1.2
Back pain experienced in last month	0.9	1.3	3.0	-0.5	-0.9	-1.7
Osteoporosis (self-reported)	0.9	1.1	2.0	0.2	-1.1	-1.4
Medication: Aspirin	0.9	1.2	2.4	-1.6	0.8	0.7
Illnesses of father: High blood pressure	0.9	1.1	2.4	0.9	-0.0	1.6
HbA1C	0.8	0.8	2.2	-1.5	0.2	-0.6
Triglycerides	0.8	1.3	1.9	-1.0	1.4	0.9
Systolic blood pressure, automated reading	0.8	2.2	4.0	-1.5	2.0	-0.6
Fed-up feelings	0.8	1.5	4.2	0.0	0.6	-2.0
Relative age voice broke	0.8	1.2	2.5	0.1	-1.1	-1.6
Qualifications: CSEs or equivalent	0.8	1.1	1.5	-1.2	1.2	-0.5
Medication: Levothyroxine sodium	0.8	1.4	3.6	0.8	-0.2	-1.9
Medication: Ramipril	0.8	1.1	2.0	-0.5	1.4	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.3	1.0	0.6	1.5
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.1	0.9	-1.8	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.8	0.6	-0.9	-1.4
Family relationship satisfaction	0.8	1.0	2.0	0.5	-1.4	0.9
Leg pain on walking	0.8	1.1	3.0	0.1	-1.7	-0.4
Eye problems/disorders: Cataract	0.8	0.9	2.4	0.6	0.1	-1.5
Breast cancer (self-reported)	0.8	0.9	1.5	1.0	-0.4	-1.2
Illnesses of father: None of the above (group 1)	0.8	1.0	1.7	-0.9	-0.7	-1.3
Medication: Atorvastatin	0.8	1.0	1.3	-1.2	1.2	0.5
Depressed Affect (Nagel 2018)	0.7	1.4	3.7	0.6	-0.5	-1.9
Reaction Time	0.7	1.4	3.7	-1.9	0.6	0.1
Ovarian Cancer	0.7	0.9	1.4	0.8	0.8	1.2
LDL Cholesterol	0.7	1.2	2.4	-0.6	-0.9	-1.6
Systolic Blood Pressure	0.7	3.4	5.1	-2.1	0.6	-2.3
Lung FVC	0.7	3.4	6.5	-2.5	0.0	-1.9
Neuroticism	0.7	1.6	3.0	0.5	-1.2	-1.7
Chronotype (morning person)	0.7	1.7	4.4	0.2	0.7	-2.1
Sensitivity / hurt feelings	0.7	1.2	2.3	-0.4	-1.1	-1.5
Diabetes (father)	0.7	0.9	2.5	0.4	0.2	1.6
Past tobacco smoking	0.7	1.2	2.9	-0.3	1.7	0.8
Had other major operations	0.7	0.9	2.2	-0.7	0.1	-1.5
Allergy	0.7	1.6	3.1	0.1	-1.8	-1.3
Impedance of arm (right)	0.7	3.0	5.9	-2.4	-0.5	-1.7
Impedance of arm (left)	0.7	3.5	7.9	-2.8	-0.6	-1.5
Loud music exposure frequency	0.7	0.7	1.8	-0.2	-1.3	0.6
Comparative body size at age 10	0.7	2.0	4.9	0.5	0.9	2.2
Number of full sisters	0.7	0.8	1.6	-0.5	-0.8	-1.3
Medication: Aspirin	0.7	1.0	1.5	-1.2	0.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.1	1.5	1.4	-0.4
Ever had bowel cancer screening	0.7	0.9	2.3	-1.5	-0.3	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.2	0.8	-0.6	1.5
Mother’s age at death	0.7	0.9	2.3	-0.3	-1.5	-0.6
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.3	-0.1	-1.5	-0.4
Medication: Paracetamol	0.7	1.0	1.4	-0.7	-1.1	-1.2
Risk taking	0.7	1.0	2.1	1.5	-0.5	0.8
Diastolic blood pressure, automated reading	0.7	2.0	4.0	-1.4	2.0	0.2
Commuting to job workplace: Cycle	0.7	0.8	2.0	0.5	0.3	1.4
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.2	1.4	-0.4	1.8
Allergy or Eczema	0.6	1.5	3.4	0.6	0.8	1.8
Hypothyroidism (self reported)	0.6	1.3	2.6	1.6	-0.5	-1.0
Ever had hysterectomy (womb removed)	0.6	0.7	0.9	-1.0	0.8	-0.6
Vitamin and mineral supplements	0.6	0.8	2.1	-0.5	1.4	0.0
Medication: Co-codamol	0.6	0.7	1.7	-0.2	0.7	-1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.2	-0.7	0.5	1.1
High blood pressure	0.6	1.6	4.7	0.1	2.2	0.4
Number of incorrect matches in round	0.6	0.9	1.8	1.3	-1.0	-0.1
Forced vital capacity (FVC)	0.6	2.1	4.0	-0.6	2.0	-1.4
Neuroticism score	0.6	1.3	2.6	0.7	-0.9	-1.6
Time employed in main current job	0.6	0.7	1.1	-0.6	1.1	0.9
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	5.9	0.2	2.4	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.0	0.0	-1.0	1.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.7	1.3	-0.5	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.1	-0.7	-0.8	-1.1
Qualifications: College or University degree	0.6	1.8	4.1	1.1	0.0	2.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	-0.1	-1.4	0.4
Supplements: Vitamin C	0.6	0.7	1.1	-0.3	-0.9	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.6	1.2	1.1	0.3	-0.8
Asthma (self-reported)	0.6	1.1	2.8	-0.4	1.7	0.7
Number of self-reported non-cancer illnesses	0.6	1.0	2.3	1.5	0.8	0.3
Average weekly champagne plus white wine intake	0.6	0.8	1.8	0.7	-0.2	1.3
Guilty feelings	0.6	0.9	1.4	0.6	-1.2	0.9
Wears glasses or contact lenses	0.6	0.7	1.2	0.6	-0.7	-1.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.9	-0.0	0.2	1.4
Bipolar Disorder (2011)	0.5	0.5	1.2	0.4	-1.1	0.0
Rheumatoid Arthritis	0.5	0.7	2.0	0.5	1.4	-0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.9	1.4	0.1	-0.2
Severe depression (siblings)	0.5	0.5	1.4	1.2	0.4	-0.3
Taking other prescription medications	0.5	0.8	2.4	0.1	0.3	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.7	-0.4	1.3	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.7	-0.1	1.3	1.3
Pulse rate	0.5	0.9	1.8	-0.5	0.8	1.3
Noisy workplace	0.5	0.6	1.1	0.0	-1.0	-0.8
Asthma	0.5	1.0	2.6	-0.2	1.6	0.5
Tense / ‘highly strung’	0.5	0.8	1.6	0.9	0.3	-1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.7	-0.3	-0.5	-1.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.9	-1.4	0.2	-0.0
Pulse wave peak to peak time	0.5	0.6	0.6	0.7	0.8	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.8	1.8	0.2	1.3	0.8
Chest pain or discomfort	0.5	0.7	1.2	0.9	-1.1	0.2
Mood swings	0.5	1.0	2.7	0.5	0.1	-1.6
Loneliness, isolation	0.5	0.7	1.0	1.0	-0.8	0.7
Medication for cholesterol	0.5	0.8	2.1	-1.5	-0.5	0.1
Miserableness	0.5	0.8	1.2	1.1	-1.1	0.1
Irritability	0.5	0.8	1.0	-0.7	-1.0	-0.9
Alzheimer’s Disease (including proxy)	0.4	0.6	1.7	1.3	0.0	0.1
Irritable Bowel Disease (IBD)	0.4	1.0	2.4	-0.5	1.6	-0.4
Coronary Artery Disease (CAD)	0.4	0.5	1.3	0.2	-0.0	1.2
Fasting Glucose	0.4	0.5	1.1	0.6	1.0	-0.3
Blood Red Count	0.4	3.9	10.3	0.8	3.2	0.9
Cardiovascular Disease	0.4	1.2	3.6	0.3	1.9	-0.0
Respiratory disease	0.4	0.8	2.3	0.0	1.5	0.1
Number of treatments/medications taken	0.4	0.8	1.4	0.2	-1.2	-1.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.3	1.2	0.2	1.1
Medication: Atenolol	0.4	0.5	0.6	0.8	0.8	-0.6
Sitting height	0.4	2.9	5.9	1.1	2.4	1.3
Worrier / anxious feelings	0.4	0.7	1.0	0.5	-1.0	-0.9
Depression (self-reported)	0.4	0.4	0.9	-0.1	-0.6	-0.9
Pulse wave Arterial Stiffness index	0.4	0.5	0.8	-0.7	-0.9	0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.1	1.0	-1.1	0.1
Medication: Amlodipine	0.4	0.5	1.2	-1.1	-0.5	-0.1
Forced vital capacity (FVC), Best measure	0.4	1.5	2.5	-0.7	1.6	-1.3
Shortness of breath walking on level ground	0.4	0.4	0.9	-0.9	-0.5	0.5
Hypertension (Self-reported)	0.4	1.1	3.3	0.2	1.8	0.3
Illnesses of siblings: Diabetes	0.4	0.4	1.1	0.3	1.1	-0.3
Long-standing illness, disability or infirmity	0.4	0.6	1.8	1.3	0.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.0	0.3	-0.5	-1.0
Average weekly beer plus cider intake	0.4	0.7	1.0	-1.0	-0.4	-0.9
Ever depressed for a whole week	0.4	0.5	0.9	0.1	-0.7	-0.9
Myopia	0.4	0.6	1.6	-0.4	0.2	1.2
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.0	-0.3	-1.7	-0.7
Neuroticism (Nagel 2018)	0.3	0.6	1.5	0.5	-0.2	-1.2
Worry (Nagel 2018)	0.3	0.6	1.2	0.7	-0.0	-1.1
Crohns Disease (2017)	0.3	0.6	1.7	0.0	1.3	0.3
Ulcerative Colitis (UC)	0.3	0.6	1.5	-0.4	1.2	-0.2
Breast Cancer	0.3	0.8	1.1	-1.1	-1.0	-0.4
Hearing difficulty/problems: Yes	0.3	0.4	1.0	0.4	0.2	1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.5	0.8	-0.2
Townsend deprivation index at recruitment	0.3	0.4	0.8	-0.3	-0.9	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.9	-0.5	-0.2
Had menopause	0.3	0.4	0.9	0.2	-0.9	0.6
Qualifications: None of the above	0.3	0.6	1.7	-0.4	-0.3	-1.3
Pain all over the body in last month	0.3	0.4	0.6	0.2	0.6	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.7	0.1	1.6	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	0.1	-0.1	-1.2
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.0	-0.6	1.0
Wheeze or whistling in the chest in last year	0.3	0.5	1.4	0.1	0.1	-1.2
Medication: Blood pressure	0.3	0.6	0.7	-0.8	0.7	0.7
Medication: Omeprazole	0.3	0.4	0.6	-0.2	0.8	-0.8
Medication: Seretide 50 evohaler	0.3	0.3	0.6	-0.2	-0.5	-0.8
Comparative height size at age 10	0.3	1.4	3.9	2.0	0.6	-0.1
Overall health rating	0.3	0.5	0.8	0.2	0.9	0.9
Crohns Disease (2012)	0.2	0.3	0.4	0.6	0.5	0.5
Lupus	0.2	0.3	0.4	0.6	0.4	-0.7
Heel T-Score	0.2	1.8	3.7	0.8	1.9	1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	0.1	0.5	0.7
Relative age of first facial hair	0.2	0.4	1.2	0.2	-0.1	-1.1
Supplements: Zinc	0.2	0.2	0.3	-0.5	-0.4	0.3
Hand grip strength (right)	0.2	0.5	1.2	-0.4	1.1	0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	-0.5	0.5	0.4
Nervous feelings	0.2	0.4	1.1	0.2	-0.1	1.1
Mouth/teeth dental problems	0.2	0.4	0.9	0.4	-0.2	-1.0
Medication: Simvastatin	0.2	0.4	0.5	0.7	0.5	0.5
Happiness	0.2	0.2	0.4	-0.1	-0.5	0.6
Standing height	0.2	2.0	5.6	0.5	2.4	-0.2
Blood clot in the leg (DVT)	0.2	0.3	0.8	0.2	0.2	0.9
Number of full brothers	0.2	0.2	0.6	-0.3	-0.1	-0.7
Eye problems/disorders: None of the above	0.2	0.3	0.3	0.5	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	0.1	0.7	0.2
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.7	0.3	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.2	0.4	0.6
Friendships satisfaction	0.2	0.2	0.5	0.7	-0.3	-0.4
Medication: Bendroflumethiazide	0.2	0.2	0.5	0.5	0.1	-0.7
Ever smoked	0.2	0.4	1.0	-0.3	-1.0	-0.5
Unable to work because of sickness or disability	0.2	0.2	0.3	0.5	-0.5	-0.4
Heart disease (siblings)	0.2	0.2	0.5	-0.5	0.7	0.0
Depression (Nagel 2018)	0.1	0.1	0.4	-0.6	0.1	0.1
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.1	0.5	-0.0
Ulcerative Colitis	0.1	0.1	0.2	0.0	0.5	0.5
Blood Platelet Count	0.1	1.5	3.5	0.4	-1.0	-1.9
Height	0.1	2.9	8.5	-0.2	2.9	-0.3
Waist Hip Ratio (WHR)	0.1	0.4	1.1	-1.0	-0.3	-0.1
Hair Pigment	0.1	1.5	3.5	-1.9	0.9	-0.4
Tanning	0.1	0.9	2.0	-0.4	-0.7	-1.4
Hand grip strength (left)	0.1	0.2	0.5	-0.1	0.7	0.1
High blood pressure (mother)	0.1	0.2	0.5	0.2	0.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.0	-0.2	0.5
Heart attack	0.1	0.1	0.2	0.2	-0.4	-0.3
Illnesses of siblings	0.1	0.1	0.3	-0.3	-0.5	-0.2
Father’s age at death	0.1	0.1	0.2	0.1	0.0	-0.5
Breastfed as a baby	0.1	0.1	0.2	-0.5	0.2	-0.2
Worry too long after embarrassment	0.1	0.2	0.2	0.5	0.5	0.3
Migraine (self-reported)	0.1	0.1	0.2	0.2	-0.2	0.4
Smoking status: Previous	0.1	0.2	0.5	-0.1	-0.7	-0.3
Commuting to job workplace: Public transport	0.1	0.2	0.5	-0.7	-0.1	-0.2
High cholesterol (Self-reported)	0.1	0.3	0.8	-0.0	0.9	-0.1
Age started oral contraceptive pill	0.1	0.1	0.2	-0.0	-0.2	0.4
Cholesterol lowering medication	0.1	0.2	0.4	0.6	-0.1	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	0.1	0.3	-0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.2	0.0	-0.5	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	0.3	-0.1	0.7
Blood Eosinophil Count	0.0	0.3	0.7	0.5	-0.8	-0.1
Blood White Count	0.0	0.0	0.0	-0.0	-0.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.3	0.2	0.1
Birth weight	0.0	0.1	0.1	0.2	-0.4	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	0.0	0.4	-0.4

Hub : Genes

NRXN3

Models

Trait associations