Hub : Genes

NSUN5P1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.1730 0.0680 0.0012 -0.004 NA -0.004 NA -0.003 0.59000 NA 0.5800 NA 0.480
2 GTEx Skin Sun Exposed Lower leg 0.0730 0.0310 0.0023 0.002 NA -0.002 NA -0.002 0.23000 NA 0.5800 NA 0.580
3 GTEx Spleen 0.3110 0.0980 0.0038 -0.011 NA 0.032 NA 0.001 0.86000 NA 0.0510 NA 0.310
4 GTEx Testis 0.1740 0.0700 0.0049 0.019 NA 0.046 NA 0.022 0.04900 NA 0.0042 NA 0.037
5 TCGA Lung Squamous Cell Carcinoma 0.0317 0.0221 0.0055 0.024 0.01 0.007 NA 0.019 0.00085 0.021 0.0420 NA 0.003

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.1 0.2 0.6 -0.6 0.0 -0.8 -0.1 0.0
Bipolar Disorder or Schizophrenia 0.1 0.1 0.5 -0.7 0.0 0.4 0.1 0.0
Depressed Affect (Nagel 2018) 0.3 0.6 1.8 0.1 0.0 -0.6 -1.3 1.0
Depression (Nagel 2018) 0.1 0.2 0.7 0.3 0.0 -0.4 0.3 0.8
Intelligence (Savage-Jansen 2018) 1.7 5.1 12.0 -3.0 0.0 0.7 2.1 3.5
Neuroticism (Nagel 2018) 0.4 0.9 2.6 0.5 0.0 -1.1 -0.8 1.6
Schizophrenia (2018) 0.2 0.3 1.4 -0.3 0.0 1.2 0.3 0.0
Schizophrenia vs Biploar Disorder 0.4 0.6 2.5 -0.6 0.0 1.6 0.0 0.0
Worry (Nagel 2018) 0.2 0.4 1.9 -0.0 0.0 -1.4 0.1 0.5
Alzheimer’s Disease (in mother) 0.4 0.5 1.1 -0.4 0.0 0.7 1.1 0.8
Alzheimer’s Disease (in father) 0.4 0.5 1.7 -1.3 0.0 -0.3 0.7 -0.1
Alzheimer’s Disease (including proxy) 0.4 0.6 1.6 -1.3 0.0 0.8 0.5 0.7
Crohns Disease (2017) 0.7 1.5 2.9 -1.2 0.0 -1.6 0.9 1.7
Irritable Bowel Disease (IBD) 0.8 1.9 3.8 -1.9 0.0 -1.3 1.1 1.7
Ulcerative Colitis (UC) 0.8 1.6 4.7 -2.2 0.0 -0.6 0.9 1.4
Major Depression (MDD) 0.2 0.2 1.1 1.0 0.0 0.3 -0.2 0.0
Reaction Time 1.0 1.9 5.9 2.4 0.0 -1.9 -0.4 0.1
Verbal and Numeric Reasoning (VNR) 1.1 2.7 9.2 -1.8 0.0 -0.1 0.9 3.0
Breast Cancer 1.4 3.3 5.7 -2.3 0.0 2.4 2.3 -0.0
Ovarian Cancer 0.5 0.7 2.7 -1.6 0.0 0.1 -0.7 -0.6
Prostate Cancer 0.4 0.5 1.9 0.1 0.0 -0.4 1.4 0.8
Age at First Birth 1.2 1.8 3.8 -1.0 0.0 -1.9 1.8 0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.2 1.7 5.0 1.8 0.0 0.4 -2.2 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 1.1 1.8 7.5 0.0 0.0 -2.7 1.2 0.0
Mean Putamen Volume 1.5 1.7 5.8 -0.7 0.0 2.4 1.4 0.0
Fasting Glucose 0.1 0.1 0.3 -0.3 0.0 -0.5 0.1 -0.5
HbA1C 1.1 1.2 3.1 -1.8 0.0 -1.6 -0.2 0.6
HDL Cholesterol 0.2 0.4 1.5 -0.4 0.0 0.4 1.2 0.4
LDL Cholesterol 1.0 1.5 5.1 -2.3 0.0 0.2 1.5 -0.4
Lupus 0.2 0.3 1.1 -0.2 0.0 -0.6 0.2 -1.0
Neuroticism (2016) 0.4 0.6 1.4 1.2 0.0 -0.5 -1.1 0.0
Primary Biliary Cirrhosis 0.2 0.3 0.8 -0.5 0.0 0.5 0.9 0.6
Rheumatoid Arthritis 0.0 0.1 0.3 -0.1 0.0 0.5 -0.0 0.0
Schizophrenia (2014) 0.1 0.3 0.8 -0.9 0.0 0.8 0.3 0.0
Triglycerides 0.2 0.3 0.8 0.9 0.0 -0.5 -0.7 -0.4
Type 2 Diabetes (T2D) (2012) 0.2 0.2 1.0 -0.4 0.0 1.0 0.0 0.0
Ulcerative Colitis 0.3 0.5 1.6 -1.3 0.0 -0.2 0.9 0.0
Blood Eosinophil Count 0.3 2.3 10.6 -3.2 0.0 0.9 -0.2 -0.5
Blood Platelet Count 0.1 1.1 4.3 -1.1 0.0 -0.5 0.3 -2.1
Blood Red Count 0.5 4.6 10.6 2.3 0.0 -2.0 -1.8 -3.3
Blood White Count 0.4 2.7 4.5 2.1 0.0 1.6 -1.9 -1.8
Heel T-Score 0.4 2.9 10.4 0.9 0.0 -1.0 -3.2 1.5
BMI 1.9 11.3 40.2 3.8 0.0 -0.1 -6.3 -1.5
Height 0.2 3.5 8.2 0.9 0.0 -2.2 2.9 1.8
Waist Hip Ratio (WHR) 0.3 1.5 3.0 -1.2 0.0 -0.5 1.7 -1.6
Systolic Blood Pressure 1.2 5.8 19.4 2.3 0.0 -1.0 -4.4 -1.7
Smoking Status 0.8 2.0 7.0 1.5 0.0 0.0 -2.6 -0.9
Allergy or Eczema 0.3 0.8 1.7 -1.3 0.0 -1.3 0.7 0.4
Cardiovascular Disease 0.5 1.8 5.2 2.3 0.0 0.6 -1.8 0.1
Hypothyroidism (self reported) 0.3 0.6 2.1 0.5 0.0 0.7 0.6 1.4
Respiratory disease 0.5 1.0 1.6 1.3 0.0 1.1 -0.9 1.2
Type 2 Diabetes (T2D) (2018) 0.8 1.5 3.5 1.9 0.0 -0.2 -1.7 1.1
Lung FEV1/FVC ratio 0.1 0.4 1.7 -1.3 0.0 0.3 -0.2 -0.0
Lung FVC 0.5 2.7 10.2 1.4 0.0 -0.6 -0.8 -3.2
Neuroticism 0.1 0.2 0.5 0.7 0.0 0.3 0.1 0.5
Chronotype (morning person) 0.1 0.3 1.0 0.4 0.0 0.0 -1.0 0.4
Hair Pigment 0.1 2.7 6.4 -0.3 0.0 -2.5 -2.2 -1.5
Tanning 0.1 1.7 4.5 -0.7 0.0 1.4 1.3 -2.1
Hand grip strength (left) 0.6 1.6 6.8 -2.6 0.0 -1.1 0.6 -0.0
Number of treatments/medications taken 0.7 1.2 5.4 0.2 0.0 0.6 0.3 -2.3
Average weekly spirits intake 0.5 0.6 1.7 -0.3 0.0 -0.4 1.3 -1.1
Sensitivity / hurt feelings 0.2 0.3 0.9 -0.9 0.0 -0.7 -0.3 0.5
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 0.4 0.0 0.2 0.3 -0.3
Hearing difficulty/problems: Yes 0.3 0.5 1.9 -0.5 0.0 0.1 0.3 -1.4
Relative age of first facial hair 0.7 1.4 3.2 -1.2 0.0 -0.2 1.6 1.8
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.4 0.6 0.0 -0.7 0.5 -1.2
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.8 0.9 0.0 0.8 -0.1 0.7
Ever had hysterectomy (womb removed) 0.3 0.4 0.9 -1.0 0.0 -0.7 -0.6 -0.3
Systolic blood pressure, automated reading 1.5 4.3 17.3 1.3 0.0 0.8 -4.2 -1.4
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 3.1 0.4 0.0 1.2 -0.5 1.8
Angina 1.6 2.1 8.4 0.6 0.0 2.9 0.2 1.4
Medication for hormone replacement therapy 0.7 0.8 3.4 1.9 0.0 0.1 -0.6 -0.1
Vitamin and mineral supplements 1.2 1.6 3.4 -1.0 0.0 -1.1 -1.9 -1.6
Supplements: Zinc 0.7 0.8 2.3 0.3 0.0 0.4 1.1 1.5
Medication: Co-codamol 0.4 0.4 1.0 0.1 0.0 0.5 -1.0 -1.0
Medication: Metformin 0.3 0.4 1.8 0.1 0.0 -0.0 -1.4 -0.3
Diabetes (father) 1.1 1.3 5.5 -0.3 0.0 -0.3 2.3 -1.0
Diabetes (mother) 2.4 3.0 9.3 -1.5 0.0 -3.0 -1.7 -0.9
Severe depression (siblings) 0.5 0.5 1.2 0.8 0.0 1.1 -0.2 0.8
Pack years adult smoking proportion 1.0 1.6 4.8 0.2 0.0 -0.4 -2.2 -1.7
Impedance of leg (right) 0.6 3.1 11.7 -0.8 0.0 1.5 3.4 1.1
Leg fat-free mass (left) 0.7 3.7 11.1 2.0 0.0 -1.9 -3.3 -0.4
Trunk fat percentage 1.2 4.9 13.7 2.7 0.0 0.1 -3.7 -1.8
Hand grip strength (right) 0.3 0.8 3.3 -1.8 0.0 -0.6 0.3 0.4
Townsend deprivation index at recruitment 0.9 1.2 3.2 0.7 0.0 0.2 -1.8 -1.5
Current tobacco smoking 0.5 0.8 2.7 0.4 0.0 0.8 -1.6 -0.6
Average weekly fortified wine intake 0.5 0.6 1.5 -0.8 0.0 -0.6 1.2 0.5
Maternal smoking around birth 1.2 1.7 6.6 0.1 0.0 1.1 -2.6 -0.8
Fed-up feelings 0.4 0.7 1.4 0.7 0.0 -1.1 -1.2 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.2 0.3 0.0 -1.1 0.7 1.1
Relative age voice broke 1.7 2.7 8.7 0.2 0.0 1.6 1.4 2.9
Taking other prescription medications 0.4 0.6 1.9 1.1 0.0 0.3 0.2 -1.4
Age when periods started (menarche) 1.4 3.3 13.2 0.8 0.0 1.5 3.6 0.8
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.2 1.5 0.0 1.1 -0.4 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.3 0.4 0.0 -1.0 -1.5 1.1
Tinnitus: Yes, but not now, but have in the past 2.0 2.2 7.1 2.7 0.0 -1.3 -0.3 -1.4
Qualifications: CSEs or equivalent 1.5 2.0 4.9 -2.2 0.0 -0.3 -0.7 -2.2
Serious illness, injury or assault to yourself 0.8 1.0 4.9 0.2 0.0 2.2 -0.0 -0.1
High blood pressure 0.5 1.5 4.2 2.0 0.0 0.8 -1.6 0.4
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.8 -1.1 0.0 -1.7 -0.0 0.5
Multivitamins +/- minerals 0.9 1.2 2.3 0.7 0.0 1.5 1.5 1.0
Stomach or abdominal pain in last month 0.4 0.5 1.3 0.9 0.0 -0.4 0.5 -1.1
Supplements: Glucosamine 1.5 2.0 4.8 -0.8 0.0 1.3 1.6 2.2
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 -0.2 0.0 1.1 1.3 -0.3
Medication: Atenolol 0.2 0.3 1.0 -0.2 0.0 1.0 0.4 0.4
Medication: Levothyroxine sodium 1.1 1.8 3.1 1.8 0.0 1.7 0.5 1.7
Sitting height 0.2 1.5 4.8 2.2 0.0 -1.2 -0.2 1.1
Chronic bronchitis/emphysema (father) 0.3 0.3 0.7 0.9 0.0 0.3 -0.4 -0.7
High blood pressure (mother) 0.2 0.3 0.7 -0.1 0.0 -0.8 0.7 -0.7
Body mass index (BMI) 1.8 7.7 29.1 2.3 0.0 -0.1 -5.4 -2.0
Impedance of leg (left) 0.7 3.3 13.4 -0.8 0.0 0.8 3.7 1.3
Leg predicted mass (left) 0.8 4.0 12.0 2.0 0.0 -1.9 -3.5 -0.4
Trunk fat mass 1.2 5.0 15.0 2.8 0.0 -0.2 -3.9 -1.6
Waist circumference 1.3 4.7 14.7 1.9 0.0 -0.6 -3.8 -2.2
Number of incorrect matches in round 1.0 1.6 6.3 -1.0 0.0 2.5 -0.1 -0.9
Past tobacco smoking 0.7 1.3 2.4 -1.5 0.0 0.1 1.3 1.5
Alcohol usually taken with meals 0.5 0.8 2.9 -0.3 0.0 0.8 0.6 1.7
Nervous feelings 0.3 0.5 2.0 -0.6 0.0 -1.4 0.3 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.4 -0.6 0.0 -0.1 0.1 -0.2
Hearing difficulty/problems with background noise 0.3 0.5 1.4 -0.6 0.0 -0.1 -1.2 0.9
Hair/balding pattern: Pattern 2 1.1 1.4 4.0 1.2 0.0 0.5 -2.0 1.0
Had menopause 0.3 0.3 0.9 0.1 0.0 0.8 -0.0 -0.9
Had other major operations 0.8 1.0 4.2 2.0 0.0 0.6 -0.1 -0.6
Forced vital capacity (FVC) 0.2 0.9 2.8 1.0 0.0 -1.7 0.4 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.5 -0.2 0.0 -0.9 -1.2 0.8
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.6 0.4 0.0 -1.2 -1.6 0.9
Qualifications: None of the above 0.8 1.7 8.1 -0.1 0.0 0.1 -0.4 -2.9
Financial difficulties in last 2 years 0.4 0.5 1.0 0.6 0.0 -0.7 -1.0 -0.9
Mouth/teeth dental problems 0.3 0.5 1.1 0.0 0.0 0.4 -1.1 1.0
Heart attack 0.7 1.0 4.3 -0.0 0.0 2.1 0.6 0.3
Allergy 0.2 0.4 0.9 0.7 0.0 1.0 0.1 0.6
Pain all over the body in last month 0.3 0.4 1.3 1.1 0.0 0.4 0.4 0.4
Diabetes (self-reported) 0.5 0.8 2.6 0.5 0.0 -1.1 -1.6 -0.5
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 3.6 -1.9 0.0 -0.1 0.5 -0.5
Medication: Ramipril 2.7 3.5 15.3 3.9 0.0 0.5 -1.1 0.9
Medication: Simvastatin 0.4 0.6 1.5 -0.3 0.0 0.7 1.2 -1.0
Fluid intelligence score 1.2 2.5 10.2 -0.3 0.0 -0.2 1.4 3.2
Illnesses of siblings 0.2 0.3 1.2 -0.4 0.0 0.1 1.1 0.2
Neuroticism score 0.1 0.2 0.7 0.3 0.0 -0.6 -0.8 -0.0
Weight 1.1 5.5 18.8 2.6 0.0 -1.1 -4.3 -0.9
Impedance of arm (right) 0.3 1.2 5.5 -0.2 0.0 0.3 2.3 -0.8
Arm fat percentage (right) 1.6 6.2 18.3 2.3 0.0 0.1 -4.3 -2.7
Trunk fat-free mass 0.2 1.3 2.5 1.0 0.0 -1.5 -1.6 0.8
Hip circumference 1.3 5.8 17.4 3.0 0.0 -0.3 -4.2 -1.5
Time employed in main current job 0.4 0.5 1.6 1.3 0.0 0.6 0.6 -0.0
Alcohol intake versus 10 years previously 0.4 0.5 2.6 0.1 0.0 -0.2 1.6 -0.4
Father’s age at death 0.4 0.5 1.4 0.8 0.0 -1.2 -0.1 -0.8
Worrier / anxious feelings 0.5 0.9 2.5 -0.8 0.0 -1.6 -1.1 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.7 0.4 0.0 0.3 -0.8 0.3
Falls in the last year 0.4 0.5 2.0 -0.1 0.0 1.4 0.3 -0.6
Hair/balding pattern: Pattern 3 0.4 0.6 1.2 1.1 0.0 -0.2 -1.0 1.0
Number of live births 0.7 1.1 4.7 0.4 0.0 2.2 0.6 -0.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 2.4 0.4 0.0 -1.5 0.5 -0.1
Pulse rate 0.5 0.9 3.3 0.9 0.0 0.5 -0.4 -1.8
Happiness 0.1 0.1 0.3 0.5 0.0 -0.1 0.4 0.5
Noisy workplace 2.2 2.8 7.9 2.8 0.0 -0.1 -1.8 -1.6
Qualifications: A levels/AS levels or equivalent 2.1 4.6 10.0 -2.1 0.0 -1.9 2.1 3.2
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 3.1 1.1 0.0 -0.1 -0.4 1.8
Mouth/teeth dental problems: Dentures 0.4 0.6 1.7 0.1 0.0 -1.1 0.3 -1.3
Asthma 0.1 0.3 0.6 0.1 0.0 0.6 -0.8 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 2.0 -0.9 0.0 -1.4 0.5 -1.0
Medication: Cholesterol lowering 0.5 0.7 3.1 0.4 0.0 0.5 -0.0 -1.8
Depression (self-reported) 1.8 2.1 6.1 1.7 0.0 1.1 -2.5 -0.6
Medication: Lansoprazole 0.6 0.7 1.7 0.6 0.0 -0.1 -1.2 1.3
Prospective memory result 0.9 1.1 4.9 0.3 0.0 -0.2 -0.7 -2.2
Lung cancer (father) 2.1 2.4 7.4 2.7 0.0 1.0 0.3 -1.9
Illnesses of mother 0.2 0.3 0.9 0.4 0.0 -0.5 -0.9 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 2.7 0.0 0.0 -1.6 1.1 -0.2
Pulse wave Arterial Stiffness index 1.3 1.6 7.1 0.4 0.0 -0.7 0.2 -2.7
Impedance of arm (left) 0.4 1.9 9.1 -0.1 0.0 0.4 3.0 -0.6
Arm fat mass (right) 1.4 5.8 19.4 2.3 0.0 -0.2 -4.4 -2.0
Trunk predicted mass 0.2 1.4 2.6 1.0 0.0 -1.5 -1.6 0.9
Standing height 0.3 2.6 4.8 1.0 0.0 -2.0 1.9 2.2
Length of working week for main job 0.4 0.5 0.9 -0.8 0.0 -0.8 -0.4 -1.0
Exposure to tobacco smoke at home 0.5 0.6 1.2 -0.1 0.0 1.1 1.1 -0.7
Breastfed as a baby 0.9 1.1 2.3 -1.5 0.0 -0.4 -0.9 1.5
Tense / ‘highly strung’ 0.4 0.7 2.0 0.5 0.0 0.1 1.0 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 2.7 0.9 0.0 -0.7 -1.6 -1.0
Hair/balding pattern: Pattern 4 0.2 0.4 1.1 -0.4 0.0 0.7 0.0 -1.0
Birth weight of first child 0.9 1.7 8.2 0.1 0.0 0.4 2.9 0.4
Peak expiratory flow (PEF) 0.2 0.5 2.1 -0.3 0.0 -0.5 0.5 1.4
Pulse wave reflection index 0.6 0.7 1.9 -0.7 0.0 -1.0 0.4 -1.4
Ever highly irritable/argumentative for 2 days 0.6 0.7 3.6 -0.2 0.0 -0.2 -1.9 -0.1
Loud music exposure frequency 0.9 1.0 2.6 -0.4 0.0 1.3 0.8 -1.6
Qualifications: O levels/GCSEs or equivalent 1.8 2.8 6.7 -1.8 0.0 -0.1 2.1 2.6
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 3.8 -0.4 0.0 1.7 0.3 -1.9
Blood clot in the leg (DVT) 0.2 0.2 0.8 0.2 0.0 0.4 -0.4 -0.9
Medication: Paracetamol 0.8 1.4 4.1 0.7 0.0 -0.4 1.5 -2.0
Headache pain in last month 0.6 1.0 2.5 -1.2 0.0 0.4 0.9 -1.6
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 4.4 -2.1 0.0 -0.7 0.5 1.3
Glaucoma (self-reported) 0.2 0.2 0.5 -0.7 0.0 0.0 -0.6 0.3
Gout (self-reported) 1.2 1.7 5.8 2.4 0.0 -0.1 -0.1 1.6
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 3.2 1.8 0.0 0.8 -0.2 1.7
Medication: Amlodipine 0.9 1.3 3.7 1.5 0.0 1.9 -0.5 -0.7
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.7 0.4 0.0 0.4 0.8 1.3
Birth weight 0.4 0.8 1.8 -1.1 0.0 -1.0 1.3 -0.0
Chronic bronchitis/emphysema (mother) 0.8 1.0 2.8 1.1 0.0 1.7 -0.4 -0.9
High blood pressure (siblings) 0.9 1.2 4.8 0.8 0.0 -0.4 -2.2 0.8
Forced vital capacity (FVC), Best measure 0.3 1.1 3.8 0.8 0.0 -2.0 1.0 -0.5
Body fat percentage 1.4 5.4 15.4 2.6 0.0 0.3 -3.9 -2.1
Leg fat percentage (right) 1.2 4.3 14.3 1.9 0.0 1.2 -3.8 -1.5
Arm fat-free mass (right) 0.3 1.4 2.9 1.1 0.0 -1.4 -1.7 0.9
Exposure to tobacco smoke outside home 0.4 0.5 1.9 0.0 0.0 1.4 0.8 -0.2
Comparative body size at age 10 0.3 0.9 2.3 -0.3 0.0 1.5 1.1 0.8
Number of full brothers 0.3 0.4 1.4 -0.6 0.0 -0.6 -1.2 -0.2
Worry too long after embarrassment 0.8 1.3 4.0 2.0 0.0 0.7 -1.4 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.2 0.1 0.0 1.1 -0.7 -0.9
Wheeze or whistling in the chest in last year 0.3 0.6 1.5 0.4 0.0 0.0 -1.1 -1.2
Number of children fathered 0.4 0.5 0.8 0.1 0.0 0.9 0.8 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.3 -0.7 0.0 -0.9 -0.2 -1.1
Age at first live birth 0.4 0.8 2.4 0.0 0.0 -1.0 0.5 1.6
Pulse wave peak to peak time 1.4 1.6 7.6 -0.4 0.0 0.6 -0.1 2.8
Health satisfaction 0.4 0.6 1.1 0.9 0.0 0.9 -0.0 -1.1
Shortness of breath walking on level ground 0.8 0.9 2.3 1.1 0.0 -0.2 -1.5 -1.0
Qualifications: College or University degree 1.2 3.7 12.0 -0.7 0.0 -2.2 0.8 3.5
Eye problems/disorders: None of the above 0.4 0.5 1.6 -0.5 0.0 -0.7 0.4 -1.3
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.7 0.3 0.0 -0.5 0.4 -0.9
Emphysema/chronic bronchitis 1.1 1.2 5.8 2.4 0.0 -0.2 -0.4 -0.5
Medication for pain relief, constipation, heartburn 0.3 0.5 1.1 -0.7 0.0 0.1 -0.9 1.0
Neck or shoulder pain in last month 1.0 1.4 3.5 1.7 0.0 0.5 0.2 -1.9
Medication: Blood pressure 1.1 1.9 5.5 2.3 0.0 1.9 -0.6 -0.2
Angina (self-reported) 1.9 2.5 9.8 0.4 0.0 3.1 0.5 1.6
Migraine (self-reported) 0.4 0.5 1.1 0.8 0.0 -0.1 -0.9 -1.0
Medication: Ibuprofen 1.0 1.2 3.3 -1.4 0.0 -1.8 0.3 -0.9
Medication: Allopurinol 2.0 2.7 8.2 2.9 0.0 1.5 -0.4 1.7
Medication: Omeprazole 0.1 0.1 0.3 -0.4 0.0 -0.6 0.2 0.0
Medication: Seretide 50 evohaler 0.6 0.7 1.3 -1.2 0.0 -0.8 -0.5 -1.1
Mean time to correctly identify matches 0.8 1.5 4.2 2.0 0.0 -1.7 -0.7 -0.1
Heart disease (mother) 0.2 0.2 0.5 0.0 0.0 -0.7 -0.7 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.7 -1.9 0.0 0.3 1.4 0.2
Whole body fat mass 1.2 5.1 15.8 2.6 0.0 -0.3 -4.0 -1.6
Leg fat mass (right) 1.4 5.3 18.6 2.4 0.0 0.0 -4.3 -1.5
Arm predicted mass (right) 0.3 1.7 3.8 1.4 0.0 -1.6 -1.9 0.6
Pulse rate, automated reading 1.5 4.9 9.8 2.3 0.0 -0.8 -3.0 -3.1
Alcohol intake frequency. 1.0 2.4 7.3 1.3 0.0 0.7 1.6 -2.7
Comparative height size at age 10 0.2 1.0 2.8 0.5 0.0 -1.7 -0.8 1.1
Number of full sisters 0.5 0.6 2.4 1.5 0.0 0.3 0.3 -0.6
Suffer from ‘nerves’ 0.4 0.6 2.6 1.6 0.0 -0.0 0.1 -0.7
Overall health rating 0.9 1.9 7.7 2.8 0.0 0.7 -0.8 -0.8
Chest pain or discomfort 1.1 1.5 4.9 0.0 0.0 0.5 -2.2 1.6
Had major operations 0.2 0.2 0.7 -0.2 0.0 -0.2 0.8 0.4
Age at last live birth 0.2 0.3 0.9 -0.1 0.0 0.4 0.9 0.5
Family relationship satisfaction 0.3 0.3 1.4 0.2 0.0 0.4 1.2 -0.3
Leg pain on walking 1.0 1.3 3.7 1.3 0.0 1.9 -0.2 -1.0
Qualifications: NVQ or HND or HNC or equivalent 2.2 2.6 6.6 -0.4 0.0 -1.1 -2.3 -2.6
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.1 0.5 0.0 0.7 -1.1 -1.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.5 0.5 0.0 -0.3 -0.1 0.7
Medication: Aspirin 0.3 0.4 2.1 0.3 0.0 1.4 -0.0 -0.2
Supplements: Vitamin C 0.4 0.4 0.9 0.8 0.0 -0.2 0.9 0.7
Knee pain experienced in last month 0.4 0.7 2.4 -0.2 0.0 1.6 0.0 -1.0
Hypertension (Self-reported) 0.5 1.4 3.5 1.9 0.0 0.6 -1.8 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.9 -0.2 0.0 -1.4 -0.3 0.2
Illnesses of father: Heart disease 0.8 1.1 4.8 -2.2 0.0 -0.0 0.1 0.8
Illnesses of siblings: Diabetes 1.0 1.2 5.9 0.1 0.0 -0.6 -0.1 -2.4
Smoking status: Previous 0.3 0.4 0.8 0.4 0.0 -0.5 -0.9 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.9 0.1 0.0 -1.4 0.1 0.6
Whole body fat-free mass 0.4 2.3 5.8 1.4 0.0 -1.8 -2.4 0.6
Leg fat-free mass (right) 0.7 3.5 9.4 1.8 0.0 -2.2 -3.1 -0.2
Arm fat percentage (left) 1.5 6.1 18.1 2.3 0.0 -0.0 -4.3 -2.6
Average weekly red wine intake 0.8 1.3 4.4 0.6 0.0 1.1 0.5 2.1
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.0 0.8 0.0 -0.8 -1.4 0.6
Mood swings 0.1 0.2 0.7 -0.5 0.0 0.2 -0.4 0.8
Loneliness, isolation 0.3 0.4 1.0 0.2 0.0 -0.1 -1.0 0.9
Long-standing illness, disability or infirmity 1.8 2.7 10.0 3.2 0.0 0.1 -1.4 -1.2
Ever had bowel cancer screening 0.4 0.5 1.0 0.7 0.0 0.2 1.0 0.9
Diabetes diagnosed by doctor 0.5 0.8 2.1 1.2 0.0 -0.4 -1.4 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 2.6 0.6 0.0 0.5 -0.6 1.6
Friendships satisfaction 0.8 1.0 3.2 1.8 0.0 -0.3 -1.1 0.8
Qualifications: nursing, teaching 1.9 2.9 8.4 -2.9 0.0 -0.9 2.1 1.0
Commuting to job workplace: Walk 0.5 0.5 1.1 -1.1 0.0 -1.1 0.4 -0.5
Eye problems/disorders: Cataract 0.7 0.8 2.6 1.1 0.0 0.4 0.0 1.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.2 0.6 0.8 0.0 0.4 0.7 -0.0
Medication for cholesterol 0.1 0.1 0.3 -0.6 0.0 -0.2 0.2 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.9 -0.8 0.0 -1.3 -1.7 0.9
Back pain experienced in last month 1.5 2.2 8.9 -1.0 0.0 -1.0 -0.5 -3.0
Mineral and other dietary supplements 1.2 1.6 4.6 -1.1 0.0 -2.1 -1.4 -0.4
Breast cancer (self-reported) 0.8 1.0 2.6 1.2 0.0 1.6 -0.6 0.7
Asthma (self-reported) 0.1 0.2 0.5 0.1 0.0 0.7 -0.6 0.5
Osteoporosis (self-reported) 0.4 0.6 2.4 0.3 0.0 0.1 -0.5 -1.6
Osteoarthritis (self-reported) 0.1 0.2 0.5 0.3 0.0 -0.7 -0.4 0.1
Medication: Aspirin 0.3 0.4 2.1 -0.1 0.0 1.5 0.3 -0.1
Medication: Gliclazide 0.5 0.6 1.0 -0.9 0.0 -0.7 -1.0 0.7
Illnesses of father: None of the above (group 1) 0.6 0.7 1.6 1.3 0.0 -0.8 -0.7 -0.9
Smoking status: Current 0.5 0.7 1.9 0.9 0.0 0.9 -1.4 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.7 0.8 0.0 -0.7 -0.7 -0.0
Whole body water mass 0.4 2.3 5.9 1.4 0.0 -1.8 -2.4 0.5
Leg predicted mass (right) 0.7 3.6 9.4 1.8 0.0 -2.3 -3.1 -0.2
Arm fat mass (left) 1.3 5.3 18.1 2.3 0.0 -0.4 -4.3 -1.7
Number of self-reported non-cancer illnesses 0.4 0.7 1.6 1.3 0.0 1.2 0.1 0.3
Average weekly champagne plus white wine intake 2.5 3.4 15.1 -0.4 0.0 0.7 -1.1 3.9
Miserableness 0.4 0.7 2.9 -0.1 0.0 -0.1 -1.7 -0.9
Guilty feelings 0.1 0.1 0.2 0.4 0.0 -0.5 -0.2 0.3
Wears glasses or contact lenses 1.3 1.5 7.0 -0.0 0.0 0.7 -0.2 2.6
Ever taken oral contraceptive pill 1.6 1.8 6.1 2.5 0.0 1.2 -1.0 0.5
Hearing aid user 0.8 0.9 2.5 -1.0 0.0 -0.7 0.7 -1.6
Mother’s age at death 0.3 0.3 1.2 -0.4 0.0 1.1 0.4 0.4
Financial situation satisfaction 0.8 1.0 4.6 0.3 0.0 0.1 0.2 -2.1
Tinnitus: Yes, now most or all of the time 1.2 1.4 3.8 -0.3 0.0 1.6 2.0 -0.7
Commuting to job workplace: Public transport 1.2 1.4 4.2 1.1 0.0 1.3 0.1 2.0
Eye problems/disorders: Glaucoma 0.6 0.7 3.3 -1.8 0.0 0.0 -0.0 0.6
Medication: Blood pressure 0.3 0.6 2.7 1.6 0.0 0.4 -0.3 0.5
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.5 0.0 0.0 -0.7 -0.4 -0.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.9 0.4 0.0 2.0 0.0 0.2
High cholesterol (Self-reported) 0.6 1.1 2.5 -1.4 0.0 1.6 0.9 -0.4
Medication: Bendroflumethiazide 0.0 0.1 0.3 0.1 0.0 0.1 0.5 -0.1
Medication: Paracetamol 1.5 2.4 6.9 0.1 0.0 -0.8 2.1 -2.6
Medication: Lisinopril 0.9 1.2 2.1 1.4 0.0 1.2 -1.1 1.0
Medication: Atorvastatin 0.8 1.0 4.4 -0.4 0.0 -0.6 0.2 -2.1
Illnesses of father: High blood pressure 0.6 0.8 2.1 -1.2 0.0 0.1 -0.6 1.5
Alcohol drinker status: Never 0.8 1.0 2.2 0.5 0.0 1.4 1.5 -0.8
Ever smoked 0.6 1.0 2.1 1.2 0.0 0.2 -1.3 -1.4
Basal metabolic rate 0.5 2.8 8.2 1.7 0.0 -1.7 -2.9 0.2
Leg fat percentage (left) 1.1 3.9 13.4 2.0 0.0 0.9 -3.7 -1.3
Arm fat-free mass (left) 0.4 1.8 5.1 1.4 0.0 -1.2 -2.2 0.8
Number of operations (self-reported) 0.3 0.5 1.0 0.9 0.0 0.6 -0.5 -1.0
Average weekly beer plus cider intake 1.6 2.3 8.1 1.1 0.0 -1.0 -1.1 -2.8
Irritability 0.6 1.0 4.0 1.0 0.0 -0.2 0.2 2.0
Risk taking 0.6 0.9 3.6 -0.4 0.0 0.7 -1.9 0.7
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.8 -0.7 0.0 -1.1 -0.5 1.3
Fractured/broken bones in last 5 years 0.5 0.7 1.7 0.9 0.0 1.3 -0.7 -0.6
Age started oral contraceptive pill 0.6 0.8 2.7 1.6 0.0 -0.5 -0.9 0.4
Diastolic blood pressure, automated reading 1.5 4.5 12.2 1.9 0.0 1.5 -3.5 -2.2
Ever depressed for a whole week 0.7 0.9 2.0 -0.9 0.0 -1.4 -1.1 0.6
Unable to work because of sickness or disability 1.2 1.6 3.7 1.8 0.0 -0.2 -1.9 -1.0
Commuting to job workplace: Cycle 0.6 0.7 1.7 -0.3 0.0 -1.3 1.3 0.6
Myopia 0.1 0.1 0.3 0.1 0.0 0.6 0.3 0.2
Vascular/heart problems diagnosed by doctor 0.6 1.6 3.7 -1.9 0.0 -1.2 1.6 -0.7
Cholesterol lowering medication 0.9 1.3 2.7 -1.6 0.0 0.8 1.3 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.1 -0.3 0.0 -0.0 0.3 0.2
Pain experienced in last month 0.6 1.0 2.9 -1.4 0.0 -0.5 -0.1 1.7
Supplements: Calcium 1.6 1.8 5.1 1.8 0.0 -0.4 2.3 -0.4
Basal cell carcinoma (self-reported) 0.3 0.4 0.8 -0.8 0.0 -0.5 0.1 0.9
Heart attack/myocardial infarction (self-reported) 0.7 1.0 3.6 -0.4 0.0 1.9 1.0 0.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.9 0.3 0.0 0.3 -0.4 -0.9
Heart disease (siblings) 0.3 0.4 0.9 0.1 0.0 0.9 -0.4 0.9
Alcohol drinker status: Previous 1.9 2.2 10.0 0.7 0.0 -0.4 -0.3 -3.2
Pack years of smoking 1.2 1.7 4.7 0.5 0.0 0.0 -2.2 -1.9
Impedance of whole body 0.6 3.0 13.9 -0.2 0.0 0.8 3.7 0.5
Leg fat mass (left) 1.4 5.3 18.3 2.5 0.0 -0.2 -4.3 -1.3
Arm predicted mass (left) 0.4 2.0 5.2 1.4 0.0 -1.5 -2.3 0.7