TWAS hub - NSUN5P1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1730	0.0680	0.0012	-0.004	NA	-0.004	NA	-0.003	0.59000	NA	0.5800	NA	0.480
2	GTEx	Skin Sun Exposed Lower leg	0.0730	0.0310	0.0023	0.002	NA	-0.002	NA	-0.002	0.23000	NA	0.5800	NA	0.580
3	GTEx	Spleen	0.3110	0.0980	0.0038	-0.011	NA	0.032	NA	0.001	0.86000	NA	0.0510	NA	0.310
4	GTEx	Testis	0.1740	0.0700	0.0049	0.019	NA	0.046	NA	0.022	0.04900	NA	0.0042	NA	0.037
5	TCGA	Lung Squamous Cell Carcinoma	0.0317	0.0221	0.0055	0.024	0.01	0.007	NA	0.019	0.00085	0.021	0.0420	NA	0.003

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5
Medication: Ramipril	2.7	3.5	15.3	3.9	0.5	-1.1	0.9
Average weekly champagne plus white wine intake	2.5	3.4	15.1	-0.4	0.7	-1.1	3.9
Diabetes (mother)	2.4	3.0	9.3	-1.5	-3.0	-1.7	-0.9
Noisy workplace	2.2	2.8	7.9	2.8	-0.1	-1.8	-1.6
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	6.6	-0.4	-1.1	-2.3	-2.6
Qualifications: A levels/AS levels or equivalent	2.1	4.6	10.0	-2.1	-1.9	2.1	3.2
Lung cancer (father)	2.1	2.4	7.4	2.7	1.0	0.3	-1.9
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	7.1	2.7	-1.3	-0.3	-1.4
Medication: Allopurinol	2.0	2.7	8.2	2.9	1.5	-0.4	1.7
BMI	1.9	11.3	40.2	3.8	-0.1	-6.3	-1.5
Angina (self-reported)	1.9	2.5	9.8	0.4	3.1	0.5	1.6
Qualifications: nursing, teaching	1.9	2.9	8.4	-2.9	-0.9	2.1	1.0
Alcohol drinker status: Previous	1.9	2.2	10.0	0.7	-0.4	-0.3	-3.2
Body mass index (BMI)	1.8	7.7	29.1	2.3	-0.1	-5.4	-2.0
Depression (self-reported)	1.8	2.1	6.1	1.7	1.1	-2.5	-0.6
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	6.7	-1.8	-0.1	2.1	2.6
Long-standing illness, disability or infirmity	1.8	2.7	10.0	3.2	0.1	-1.4	-1.2
Intelligence (Savage-Jansen 2018)	1.7	5.1	12.0	-3.0	0.7	2.1	3.5
Relative age voice broke	1.7	2.7	8.7	0.2	1.6	1.4	2.9
Angina	1.6	2.1	8.4	0.6	2.9	0.2	1.4
Arm fat percentage (right)	1.6	6.2	18.3	2.3	0.1	-4.3	-2.7
Ever taken oral contraceptive pill	1.6	1.8	6.1	2.5	1.2	-1.0	0.5
Average weekly beer plus cider intake	1.6	2.3	8.1	1.1	-1.0	-1.1	-2.8
Supplements: Calcium	1.6	1.8	5.1	1.8	-0.4	2.3	-0.4
Mean Putamen Volume	1.5	1.7	5.8	-0.7	2.4	1.4	0.0
Systolic blood pressure, automated reading	1.5	4.3	17.3	1.3	0.8	-4.2	-1.4
Qualifications: CSEs or equivalent	1.5	2.0	4.9	-2.2	-0.3	-0.7	-2.2
Supplements: Glucosamine	1.5	2.0	4.8	-0.8	1.3	1.6	2.2
Pulse rate, automated reading	1.5	4.9	9.8	2.3	-0.8	-3.0	-3.1
Arm fat percentage (left)	1.5	6.1	18.1	2.3	-0.0	-4.3	-2.6
Back pain experienced in last month	1.5	2.2	8.9	-1.0	-1.0	-0.5	-3.0
Medication: Paracetamol	1.5	2.4	6.9	0.1	-0.8	2.1	-2.6
Diastolic blood pressure, automated reading	1.5	4.5	12.2	1.9	1.5	-3.5	-2.2
Breast Cancer	1.4	3.3	5.7	-2.3	2.4	2.3	-0.0
Age when periods started (menarche)	1.4	3.3	13.2	0.8	1.5	3.6	0.8
Arm fat mass (right)	1.4	5.8	19.4	2.3	-0.2	-4.4	-2.0
Body fat percentage	1.4	5.4	15.4	2.6	0.3	-3.9	-2.1
Pulse wave peak to peak time	1.4	1.6	7.6	-0.4	0.6	-0.1	2.8
Leg fat mass (right)	1.4	5.3	18.6	2.4	0.0	-4.3	-1.5
Leg fat mass (left)	1.4	5.3	18.3	2.5	-0.2	-4.3	-1.3
Waist circumference	1.3	4.7	14.7	1.9	-0.6	-3.8	-2.2
Hip circumference	1.3	5.8	17.4	3.0	-0.3	-4.2	-1.5
Pulse wave Arterial Stiffness index	1.3	1.6	7.1	0.4	-0.7	0.2	-2.7
Arm fat mass (left)	1.3	5.3	18.1	2.3	-0.4	-4.3	-1.7
Wears glasses or contact lenses	1.3	1.5	7.0	-0.0	0.7	-0.2	2.6
Age at First Birth	1.2	1.8	3.8	-1.0	-1.9	1.8	0.9
Body Mass Index (BMI) (2010)	1.2	1.7	5.0	1.8	0.4	-2.2	0.0
Systolic Blood Pressure	1.2	5.8	19.4	2.3	-1.0	-4.4	-1.7
Vitamin and mineral supplements	1.2	1.6	3.4	-1.0	-1.1	-1.9	-1.6
Trunk fat percentage	1.2	4.9	13.7	2.7	0.1	-3.7	-1.8
Maternal smoking around birth	1.2	1.7	6.6	0.1	1.1	-2.6	-0.8
Trunk fat mass	1.2	5.0	15.0	2.8	-0.2	-3.9	-1.6
Fluid intelligence score	1.2	2.5	10.2	-0.3	-0.2	1.4	3.2
Gout (self-reported)	1.2	1.7	5.8	2.4	-0.1	-0.1	1.6
Leg fat percentage (right)	1.2	4.3	14.3	1.9	1.2	-3.8	-1.5
Qualifications: College or University degree	1.2	3.7	12.0	-0.7	-2.2	0.8	3.5
Whole body fat mass	1.2	5.1	15.8	2.6	-0.3	-4.0	-1.6
Mineral and other dietary supplements	1.2	1.6	4.6	-1.1	-2.1	-1.4	-0.4
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.8	-0.3	1.6	2.0	-0.7
Commuting to job workplace: Public transport	1.2	1.4	4.2	1.1	1.3	0.1	2.0
Unable to work because of sickness or disability	1.2	1.6	3.7	1.8	-0.2	-1.9	-1.0
Pack years of smoking	1.2	1.7	4.7	0.5	0.0	-2.2	-1.9
Verbal and Numeric Reasoning (VNR)	1.1	2.7	9.2	-1.8	-0.1	0.9	3.0
Crohns Disease (2012)	1.1	1.8	7.5	0.0	-2.7	1.2	0.0
HbA1C	1.1	1.2	3.1	-1.8	-1.6	-0.2	0.6
Diabetes (father)	1.1	1.3	5.5	-0.3	-0.3	2.3	-1.0
Medication: Levothyroxine sodium	1.1	1.8	3.1	1.8	1.7	0.5	1.7
Hair/balding pattern: Pattern 2	1.1	1.4	4.0	1.2	0.5	-2.0	1.0
Weight	1.1	5.5	18.8	2.6	-1.1	-4.3	-0.9
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.8	-0.4	1.7	0.3	-1.9
Emphysema/chronic bronchitis	1.1	1.2	5.8	2.4	-0.2	-0.4	-0.5
Medication: Blood pressure	1.1	1.9	5.5	2.3	1.9	-0.6	-0.2
Chest pain or discomfort	1.1	1.5	4.9	0.0	0.5	-2.2	1.6
Leg fat percentage (left)	1.1	3.9	13.4	2.0	0.9	-3.7	-1.3
Reaction Time	1.0	1.9	5.9	2.4	-1.9	-0.4	0.1
LDL Cholesterol	1.0	1.5	5.1	-2.3	0.2	1.5	-0.4
Pack years adult smoking proportion	1.0	1.6	4.8	0.2	-0.4	-2.2	-1.7
Number of incorrect matches in round	1.0	1.6	6.3	-1.0	2.5	-0.1	-0.9
Neck or shoulder pain in last month	1.0	1.4	3.5	1.7	0.5	0.2	-1.9
Medication: Ibuprofen	1.0	1.2	3.3	-1.4	-1.8	0.3	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.7	-1.9	0.3	1.4	0.2
Alcohol intake frequency.	1.0	2.4	7.3	1.3	0.7	1.6	-2.7
Leg pain on walking	1.0	1.3	3.7	1.3	1.9	-0.2	-1.0
Illnesses of siblings: Diabetes	1.0	1.2	5.9	0.1	-0.6	-0.1	-2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.9	-0.8	-1.3	-1.7	0.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.1	0.4	1.2	-0.5	1.8
Townsend deprivation index at recruitment	0.9	1.2	3.2	0.7	0.2	-1.8	-1.5
Multivitamins +/- minerals	0.9	1.2	2.3	0.7	1.5	1.5	1.0
Prospective memory result	0.9	1.1	4.9	0.3	-0.2	-0.7	-2.2
Breastfed as a baby	0.9	1.1	2.3	-1.5	-0.4	-0.9	1.5
Birth weight of first child	0.9	1.7	8.2	0.1	0.4	2.9	0.4
Loud music exposure frequency	0.9	1.0	2.6	-0.4	1.3	0.8	-1.6
Medication: Amlodipine	0.9	1.3	3.7	1.5	1.9	-0.5	-0.7
High blood pressure (siblings)	0.9	1.2	4.8	0.8	-0.4	-2.2	0.8
Overall health rating	0.9	1.9	7.7	2.8	0.7	-0.8	-0.8
Medication: Lisinopril	0.9	1.2	2.1	1.4	1.2	-1.1	1.0
Cholesterol lowering medication	0.9	1.3	2.7	-1.6	0.8	1.3	-1.1
Irritable Bowel Disease (IBD)	0.8	1.9	3.8	-1.9	-1.3	1.1	1.7
Ulcerative Colitis (UC)	0.8	1.6	4.7	-2.2	-0.6	0.9	1.4
Smoking Status	0.8	2.0	7.0	1.5	0.0	-2.6	-0.9
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.5	1.9	-0.2	-1.7	1.1
Serious illness, injury or assault to yourself	0.8	1.0	4.9	0.2	2.2	-0.0	-0.1
Leg predicted mass (left)	0.8	4.0	12.0	2.0	-1.9	-3.5	-0.4
Had other major operations	0.8	1.0	4.2	2.0	0.6	-0.1	-0.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.6	0.4	-1.2	-1.6	0.9
Qualifications: None of the above	0.8	1.7	8.1	-0.1	0.1	-0.4	-2.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.1	1.1	-0.1	-0.4	1.8
Medication: Paracetamol	0.8	1.4	4.1	0.7	-0.4	1.5	-2.0
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	4.4	-2.1	-0.7	0.5	1.3
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.8	1.1	1.7	-0.4	-0.9
Worry too long after embarrassment	0.8	1.3	4.0	2.0	0.7	-1.4	0.3
Shortness of breath walking on level ground	0.8	0.9	2.3	1.1	-0.2	-1.5	-1.0
Mean time to correctly identify matches	0.8	1.5	4.2	2.0	-1.7	-0.7	-0.1
Illnesses of father: Heart disease	0.8	1.1	4.8	-2.2	-0.0	0.1	0.8
Average weekly red wine intake	0.8	1.3	4.4	0.6	1.1	0.5	2.1
Friendships satisfaction	0.8	1.0	3.2	1.8	-0.3	-1.1	0.8
Breast cancer (self-reported)	0.8	1.0	2.6	1.2	1.6	-0.6	0.7
Hearing aid user	0.8	0.9	2.5	-1.0	-0.7	0.7	-1.6
Financial situation satisfaction	0.8	1.0	4.6	0.3	0.1	0.2	-2.1
Medication: Atorvastatin	0.8	1.0	4.4	-0.4	-0.6	0.2	-2.1
Alcohol drinker status: Never	0.8	1.0	2.2	0.5	1.4	1.5	-0.8
Crohns Disease (2017)	0.7	1.5	2.9	-1.2	-1.6	0.9	1.7
Number of treatments/medications taken	0.7	1.2	5.4	0.2	0.6	0.3	-2.3
Relative age of first facial hair	0.7	1.4	3.2	-1.2	-0.2	1.6	1.8
Medication for hormone replacement therapy	0.7	0.8	3.4	1.9	0.1	-0.6	-0.1
Supplements: Zinc	0.7	0.8	2.3	0.3	0.4	1.1	1.5
Leg fat-free mass (left)	0.7	3.7	11.1	2.0	-1.9	-3.3	-0.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.2	1.5	1.1	-0.4	0.7
Impedance of leg (left)	0.7	3.3	13.4	-0.8	0.8	3.7	1.3
Past tobacco smoking	0.7	1.3	2.4	-1.5	0.1	1.3	1.5
Heart attack	0.7	1.0	4.3	-0.0	2.1	0.6	0.3
Number of live births	0.7	1.1	4.7	0.4	2.2	0.6	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.0	-0.9	-1.4	0.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.2	1.8	0.8	-0.2	1.7
Leg fat-free mass (right)	0.7	3.5	9.4	1.8	-2.2	-3.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.6	0.6	0.5	-0.6	1.6
Eye problems/disorders: Cataract	0.7	0.8	2.6	1.1	0.4	0.0	1.6
Leg predicted mass (right)	0.7	3.6	9.4	1.8	-2.3	-3.1	-0.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	-0.7	-1.1	-0.5	1.3
Ever depressed for a whole week	0.7	0.9	2.0	-0.9	-1.4	-1.1	0.6
Heart attack/myocardial infarction (self-reported)	0.7	1.0	3.6	-0.4	1.9	1.0	0.2
Hand grip strength (left)	0.6	1.6	6.8	-2.6	-1.1	0.6	-0.0
Impedance of leg (right)	0.6	3.1	11.7	-0.8	1.5	3.4	1.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.6	-1.9	-0.1	0.5	-0.5
Medication: Lansoprazole	0.6	0.7	1.7	0.6	-0.1	-1.2	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.7	0.9	-0.7	-1.6	-1.0
Pulse wave reflection index	0.6	0.7	1.9	-0.7	-1.0	0.4	-1.4
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.6	-0.2	-0.2	-1.9	-0.1
Headache pain in last month	0.6	1.0	2.5	-1.2	0.4	0.9	-1.6
Medication: Seretide 50 evohaler	0.6	0.7	1.3	-1.2	-0.8	-0.5	-1.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.0	0.8	-0.8	-1.4	0.6
Illnesses of father: None of the above (group 1)	0.6	0.7	1.6	1.3	-0.8	-0.7	-0.9
Eye problems/disorders: Glaucoma	0.6	0.7	3.3	-1.8	0.0	-0.0	0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.9	0.4	2.0	0.0	0.2
High cholesterol (Self-reported)	0.6	1.1	2.5	-1.4	1.6	0.9	-0.4
Illnesses of father: High blood pressure	0.6	0.8	2.1	-1.2	0.1	-0.6	1.5
Ever smoked	0.6	1.0	2.1	1.2	0.2	-1.3	-1.4
Irritability	0.6	1.0	4.0	1.0	-0.2	0.2	2.0
Risk taking	0.6	0.9	3.6	-0.4	0.7	-1.9	0.7
Age started oral contraceptive pill	0.6	0.8	2.7	1.6	-0.5	-0.9	0.4
Commuting to job workplace: Cycle	0.6	0.7	1.7	-0.3	-1.3	1.3	0.6
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.7	-1.9	-1.2	1.6	-0.7
Pain experienced in last month	0.6	1.0	2.9	-1.4	-0.5	-0.1	1.7
Impedance of whole body	0.6	3.0	13.9	-0.2	0.8	3.7	0.5
Ovarian Cancer	0.5	0.7	2.7	-1.6	0.1	-0.7	-0.6
Blood Red Count	0.5	4.6	10.6	2.3	-2.0	-1.8	-3.3
Cardiovascular Disease	0.5	1.8	5.2	2.3	0.6	-1.8	0.1
Respiratory disease	0.5	1.0	1.6	1.3	1.1	-0.9	1.2
Lung FVC	0.5	2.7	10.2	1.4	-0.6	-0.8	-3.2
Average weekly spirits intake	0.5	0.6	1.7	-0.3	-0.4	1.3	-1.1
Severe depression (siblings)	0.5	0.5	1.2	0.8	1.1	-0.2	0.8
Current tobacco smoking	0.5	0.8	2.7	0.4	0.8	-1.6	-0.6
Average weekly fortified wine intake	0.5	0.6	1.5	-0.8	-0.6	1.2	0.5
High blood pressure	0.5	1.5	4.2	2.0	0.8	-1.6	0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	-0.2	1.1	1.3	-0.3
Alcohol usually taken with meals	0.5	0.8	2.9	-0.3	0.8	0.6	1.7
Diabetes (self-reported)	0.5	0.8	2.6	0.5	-1.1	-1.6	-0.5
Worrier / anxious feelings	0.5	0.9	2.5	-0.8	-1.6	-1.1	0.3
Pulse rate	0.5	0.9	3.3	0.9	0.5	-0.4	-1.8
Medication: Cholesterol lowering	0.5	0.7	3.1	0.4	0.5	-0.0	-1.8
Exposure to tobacco smoke at home	0.5	0.6	1.2	-0.1	1.1	1.1	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	-0.7	-0.9	-0.2	-1.1
Number of full sisters	0.5	0.6	2.4	1.5	0.3	0.3	-0.6
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	0.5	0.7	-1.1	-1.1
Hypertension (Self-reported)	0.5	1.4	3.5	1.9	0.6	-1.8	-0.0
Diabetes diagnosed by doctor	0.5	0.8	2.1	1.2	-0.4	-1.4	-0.1
Commuting to job workplace: Walk	0.5	0.5	1.1	-1.1	-1.1	0.4	-0.5
Medication: Gliclazide	0.5	0.6	1.0	-0.9	-0.7	-1.0	0.7
Smoking status: Current	0.5	0.7	1.9	0.9	0.9	-1.4	-0.3
Basal metabolic rate	0.5	2.8	8.2	1.7	-1.7	-2.9	0.2
Fractured/broken bones in last 5 years	0.5	0.7	1.7	0.9	1.3	-0.7	-0.6
Neuroticism (Nagel 2018)	0.4	0.9	2.6	0.5	-1.1	-0.8	1.6
Schizophrenia vs Biploar Disorder	0.4	0.6	2.5	-0.6	1.6	0.0	0.0
Alzheimer’s Disease (in mother)	0.4	0.5	1.1	-0.4	0.7	1.1	0.8
Alzheimer’s Disease (in father)	0.4	0.5	1.7	-1.3	-0.3	0.7	-0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	-1.3	0.8	0.5	0.7
Prostate Cancer	0.4	0.5	1.9	0.1	-0.4	1.4	0.8
Neuroticism (2016)	0.4	0.6	1.4	1.2	-0.5	-1.1	0.0
Blood White Count	0.4	2.7	4.5	2.1	1.6	-1.9	-1.8
Heel T-Score	0.4	2.9	10.4	0.9	-1.0	-3.2	1.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.4	0.6	-0.7	0.5	-1.2
Medication: Co-codamol	0.4	0.4	1.0	0.1	0.5	-1.0	-1.0
Fed-up feelings	0.4	0.7	1.4	0.7	-1.1	-1.2	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	0.3	-1.1	0.7	1.1
Taking other prescription medications	0.4	0.6	1.9	1.1	0.3	0.2	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.3	0.4	-1.0	-1.5	1.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.8	-1.1	-1.7	-0.0	0.5
Stomach or abdominal pain in last month	0.4	0.5	1.3	0.9	-0.4	0.5	-1.1
Financial difficulties in last 2 years	0.4	0.5	1.0	0.6	-0.7	-1.0	-0.9
Medication: Simvastatin	0.4	0.6	1.5	-0.3	0.7	1.2	-1.0
Time employed in main current job	0.4	0.5	1.6	1.3	0.6	0.6	-0.0
Alcohol intake versus 10 years previously	0.4	0.5	2.6	0.1	-0.2	1.6	-0.4
Father’s age at death	0.4	0.5	1.4	0.8	-1.2	-0.1	-0.8
Falls in the last year	0.4	0.5	2.0	-0.1	1.4	0.3	-0.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.2	1.1	-0.2	-1.0	1.0
Mouth/teeth dental problems: Dentures	0.4	0.6	1.7	0.1	-1.1	0.3	-1.3
Impedance of arm (left)	0.4	1.9	9.1	-0.1	0.4	3.0	-0.6
Length of working week for main job	0.4	0.5	0.9	-0.8	-0.8	-0.4	-1.0
Tense / ‘highly strung’	0.4	0.7	2.0	0.5	0.1	1.0	-1.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	0.4	0.4	0.8	1.3
Birth weight	0.4	0.8	1.8	-1.1	-1.0	1.3	-0.0
Exposure to tobacco smoke outside home	0.4	0.5	1.9	0.0	1.4	0.8	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	0.1	1.1	-0.7	-0.9
Number of children fathered	0.4	0.5	0.8	0.1	0.9	0.8	-0.9
Age at first live birth	0.4	0.8	2.4	0.0	-1.0	0.5	1.6
Health satisfaction	0.4	0.6	1.1	0.9	0.9	-0.0	-1.1
Eye problems/disorders: None of the above	0.4	0.5	1.6	-0.5	-0.7	0.4	-1.3
Migraine (self-reported)	0.4	0.5	1.1	0.8	-0.1	-0.9	-1.0
Suffer from ‘nerves’	0.4	0.6	2.6	1.6	-0.0	0.1	-0.7
Supplements: Vitamin C	0.4	0.4	0.9	0.8	-0.2	0.9	0.7
Knee pain experienced in last month	0.4	0.7	2.4	-0.2	1.6	0.0	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.9	-0.2	-1.4	-0.3	0.2
Whole body fat-free mass	0.4	2.3	5.8	1.4	-1.8	-2.4	0.6
Ever had bowel cancer screening	0.4	0.5	1.0	0.7	0.2	1.0	0.9
Osteoporosis (self-reported)	0.4	0.6	2.4	0.3	0.1	-0.5	-1.6
Whole body water mass	0.4	2.3	5.9	1.4	-1.8	-2.4	0.5
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	1.3	1.2	0.1	0.3
Miserableness	0.4	0.7	2.9	-0.1	-0.1	-1.7	-0.9
Arm fat-free mass (left)	0.4	1.8	5.1	1.4	-1.2	-2.2	0.8
Arm predicted mass (left)	0.4	2.0	5.2	1.4	-1.5	-2.3	0.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.8	0.1	-0.6	-1.3	1.0
Ulcerative Colitis	0.3	0.5	1.6	-1.3	-0.2	0.9	0.0
Blood Eosinophil Count	0.3	2.3	10.6	-3.2	0.9	-0.2	-0.5
Waist Hip Ratio (WHR)	0.3	1.5	3.0	-1.2	-0.5	1.7	-1.6
Allergy or Eczema	0.3	0.8	1.7	-1.3	-1.3	0.7	0.4
Hypothyroidism (self reported)	0.3	0.6	2.1	0.5	0.7	0.6	1.4
Hearing difficulty/problems: Yes	0.3	0.5	1.9	-0.5	0.1	0.3	-1.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	0.9	0.8	-0.1	0.7
Ever had hysterectomy (womb removed)	0.3	0.4	0.9	-1.0	-0.7	-0.6	-0.3
Medication: Metformin	0.3	0.4	1.8	0.1	-0.0	-1.4	-0.3
Hand grip strength (right)	0.3	0.8	3.3	-1.8	-0.6	0.3	0.4
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	0.9	0.3	-0.4	-0.7
Nervous feelings	0.3	0.5	2.0	-0.6	-1.4	0.3	0.2
Hearing difficulty/problems with background noise	0.3	0.5	1.4	-0.6	-0.1	-1.2	0.9
Had menopause	0.3	0.3	0.9	0.1	0.8	-0.0	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.5	-0.2	-0.9	-1.2	0.8
Mouth/teeth dental problems	0.3	0.5	1.1	0.0	0.4	-1.1	1.0
Pain all over the body in last month	0.3	0.4	1.3	1.1	0.4	0.4	0.4
Impedance of arm (right)	0.3	1.2	5.5	-0.2	0.3	2.3	-0.8
Standing height	0.3	2.6	4.8	1.0	-2.0	1.9	2.2
Forced vital capacity (FVC), Best measure	0.3	1.1	3.8	0.8	-2.0	1.0	-0.5
Arm fat-free mass (right)	0.3	1.4	2.9	1.1	-1.4	-1.7	0.9
Comparative body size at age 10	0.3	0.9	2.3	-0.3	1.5	1.1	0.8
Number of full brothers	0.3	0.4	1.4	-0.6	-0.6	-1.2	-0.2
Wheeze or whistling in the chest in last year	0.3	0.6	1.5	0.4	0.0	-1.1	-1.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.1	-0.7	0.1	-0.9	1.0
Arm predicted mass (right)	0.3	1.7	3.8	1.4	-1.6	-1.9	0.6
Family relationship satisfaction	0.3	0.3	1.4	0.2	0.4	1.2	-0.3
Medication: Aspirin	0.3	0.4	2.1	0.3	1.4	-0.0	-0.2
Smoking status: Previous	0.3	0.4	0.8	0.4	-0.5	-0.9	-0.9
Loneliness, isolation	0.3	0.4	1.0	0.2	-0.1	-1.0	0.9
Medication: Aspirin	0.3	0.4	2.1	-0.1	1.5	0.3	-0.1
Mother’s age at death	0.3	0.3	1.2	-0.4	1.1	0.4	0.4
Medication: Blood pressure	0.3	0.6	2.7	1.6	0.4	-0.3	0.5
Number of operations (self-reported)	0.3	0.5	1.0	0.9	0.6	-0.5	-1.0
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	-0.8	-0.5	0.1	0.9
Heart disease (siblings)	0.3	0.4	0.9	0.1	0.9	-0.4	0.9
Schizophrenia (2018)	0.2	0.3	1.4	-0.3	1.2	0.3	0.0
Worry (Nagel 2018)	0.2	0.4	1.9	-0.0	-1.4	0.1	0.5
Major Depression (MDD)	0.2	0.2	1.1	1.0	0.3	-0.2	0.0
HDL Cholesterol	0.2	0.4	1.5	-0.4	0.4	1.2	0.4
Lupus	0.2	0.3	1.1	-0.2	-0.6	0.2	-1.0
Primary Biliary Cirrhosis	0.2	0.3	0.8	-0.5	0.5	0.9	0.6
Triglycerides	0.2	0.3	0.8	0.9	-0.5	-0.7	-0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.0	-0.4	1.0	0.0	0.0
Height	0.2	3.5	8.2	0.9	-2.2	2.9	1.8
Sensitivity / hurt feelings	0.2	0.3	0.9	-0.9	-0.7	-0.3	0.5
Medication: Atenolol	0.2	0.3	1.0	-0.2	1.0	0.4	0.4
Sitting height	0.2	1.5	4.8	2.2	-1.2	-0.2	1.1
High blood pressure (mother)	0.2	0.3	0.7	-0.1	-0.8	0.7	-0.7
Forced vital capacity (FVC)	0.2	0.9	2.8	1.0	-1.7	0.4	-0.8
Allergy	0.2	0.4	0.9	0.7	1.0	0.1	0.6
Illnesses of siblings	0.2	0.3	1.2	-0.4	0.1	1.1	0.2
Trunk fat-free mass	0.2	1.3	2.5	1.0	-1.5	-1.6	0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.4	0.4	-1.5	0.5	-0.1
Illnesses of mother	0.2	0.3	0.9	0.4	-0.5	-0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.7	0.0	-1.6	1.1	-0.2
Trunk predicted mass	0.2	1.4	2.6	1.0	-1.5	-1.6	0.9
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	-0.4	0.7	0.0	-1.0
Peak expiratory flow (PEF)	0.2	0.5	2.1	-0.3	-0.5	0.5	1.4
Blood clot in the leg (DVT)	0.2	0.2	0.8	0.2	0.4	-0.4	-0.9
Glaucoma (self-reported)	0.2	0.2	0.5	-0.7	0.0	-0.6	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	0.3	-0.5	0.4	-0.9
Heart disease (mother)	0.2	0.2	0.5	0.0	-0.7	-0.7	-0.1
Comparative height size at age 10	0.2	1.0	2.8	0.5	-1.7	-0.8	1.1
Had major operations	0.2	0.2	0.7	-0.2	-0.2	0.8	0.4
Age at last live birth	0.2	0.3	0.9	-0.1	0.4	0.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.9	0.1	-1.4	0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.6	0.8	0.4	0.7	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.7	0.8	-0.7	-0.7	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.9	0.3	0.3	-0.4	-0.9
Bipolar Disorder (2018)	0.1	0.2	0.6	-0.6	-0.8	-0.1	0.0
Bipolar Disorder or Schizophrenia	0.1	0.1	0.5	-0.7	0.4	0.1	0.0
Depression (Nagel 2018)	0.1	0.2	0.7	0.3	-0.4	0.3	0.8
Fasting Glucose	0.1	0.1	0.3	-0.3	-0.5	0.1	-0.5
Schizophrenia (2014)	0.1	0.3	0.8	-0.9	0.8	0.3	0.0
Blood Platelet Count	0.1	1.1	4.3	-1.1	-0.5	0.3	-2.1
Lung FEV1/FVC ratio	0.1	0.4	1.7	-1.3	0.3	-0.2	-0.0
Neuroticism	0.1	0.2	0.5	0.7	0.3	0.1	0.5
Chronotype (morning person)	0.1	0.3	1.0	0.4	0.0	-1.0	0.4
Hair Pigment	0.1	2.7	6.4	-0.3	-2.5	-2.2	-1.5
Tanning	0.1	1.7	4.5	-0.7	1.4	1.3	-2.1
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.4	0.2	0.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	-0.6	-0.1	0.1	-0.2
Neuroticism score	0.1	0.2	0.7	0.3	-0.6	-0.8	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	0.4	0.3	-0.8	0.3
Happiness	0.1	0.1	0.3	0.5	-0.1	0.4	0.5
Asthma	0.1	0.3	0.6	0.1	0.6	-0.8	0.6
Medication: Omeprazole	0.1	0.1	0.3	-0.4	-0.6	0.2	0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.5	0.5	-0.3	-0.1	0.7
Mood swings	0.1	0.2	0.7	-0.5	0.2	-0.4	0.8
Medication for cholesterol	0.1	0.1	0.3	-0.6	-0.2	0.2	-0.4
Asthma (self-reported)	0.1	0.2	0.5	0.1	0.7	-0.6	0.5
Osteoarthritis (self-reported)	0.1	0.2	0.5	0.3	-0.7	-0.4	0.1
Guilty feelings	0.1	0.1	0.2	0.4	-0.5	-0.2	0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.5	0.0	-0.7	-0.4	-0.2
Myopia	0.1	0.1	0.3	0.1	0.6	0.3	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.1	0.3	-0.1	0.5	-0.0	0.0
Medication: Bendroflumethiazide	0.0	0.1	0.3	0.1	0.1	0.5	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	-0.3	-0.0	0.3	0.2

Hub : Genes

NSUN5P1

Models

Trait associations