TWAS hub - NTM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.106	0.0350	2.1e-03	0.010	0.038	0.039	0.044	0.042	1.9e-02	1.8e-05	1.5e-05	4.3e-06	6.1e-06
2	GTEx	Lung	0.433	0.0642	2.1e-08	0.319	NA	0.358	NA	0.347	5.8e-25	NA	1.8e-28	NA	1.7e-27
3	GTEx	Nerve Tibial	0.204	0.0538	1.1e-04	0.065	NA	0.112	NA	0.071	2.2e-05	NA	2.6e-08	NA	9.4e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Prostate Cancer	5.9	8.3	19.7	4.4	0.1	-2.2
Exposure to tobacco smoke at home	4.0	4.5	7.1	-1.1	-2.3	2.7
Lung FEV1/FVC ratio	3.7	18.7	45.1	-0.7	-3.2	6.7
Average weekly beer plus cider intake	3.6	5.2	14.8	-3.9	-0.4	0.7
Qualifications: CSEs or equivalent	3.1	4.1	8.1	0.5	-2.9	2.0
Ovarian Cancer	2.9	3.9	7.1	-1.8	1.2	2.7
HbA1C	2.7	3.0	8.0	-2.8	0.8	-0.7
Shortness of breath walking on level ground	2.7	3.3	5.8	2.4	2.0	0.3
Qualifications: College or University degree	2.7	8.5	20.7	-0.7	4.5	2.1
Unable to work because of sickness or disability	2.7	3.5	8.5	-1.5	-2.9	0.1
Maternal smoking around birth	2.6	3.8	6.0	-2.0	2.4	1.2
Knee pain experienced in last month	2.6	4.1	12.0	0.6	-3.5	0.1
Average weekly red wine intake	2.6	3.9	8.9	1.3	3.0	-1.1
Body Mass Index (BMI) (2010)	2.5	3.4	8.0	0.7	1.3	2.8
Ulcerative Colitis	2.5	3.6	6.0	2.5	2.2	-0.1
Glaucoma (self-reported)	2.5	2.9	5.0	-1.5	2.2	1.2
Ever depressed for a whole week	2.4	3.0	6.3	0.3	1.6	2.5
Basal cell carcinoma (self-reported)	2.4	2.9	4.6	1.8	0.7	-2.2
Prospective memory result	2.3	2.9	4.0	1.9	2.0	-1.0
Overall health rating	2.3	4.9	9.8	-1.7	-3.1	1.4
Pain experienced in last month	2.3	3.8	10.7	0.6	3.3	-0.5
Medication: Co-codamol	2.2	2.5	3.2	-1.4	-1.8	-1.5
Number of incorrect matches in round	2.2	3.7	10.8	-0.4	0.3	3.3
Neck or shoulder pain in last month	2.2	3.1	7.7	1.2	-2.8	-0.0
Heart disease (mother)	2.2	2.7	5.7	-1.3	0.9	2.4
Medication for cholesterol	2.2	3.3	8.1	1.3	0.5	-2.9
Mouth/teeth dental problems: Bleeding gums	2.1	2.8	5.4	1.5	-0.8	2.3
Irritable Bowel Disease (IBD)	2.0	4.8	10.1	3.2	1.8	1.1
Medication: Blood pressure	2.0	3.7	11.2	0.2	0.0	3.3
Ever smoked	2.0	3.5	9.9	-3.1	-0.0	0.8
Fasting Glucose	1.9	2.3	4.5	-1.3	0.9	-2.1
Hypothyroidism (self reported)	1.9	4.2	8.8	-1.8	-3.0	0.8
Diabetes (mother)	1.9	2.4	4.5	0.2	1.6	2.1
Hypothyroidism/myxoedema (self-reported)	1.9	3.6	6.3	-1.8	-2.5	1.1
Body fat percentage	1.9	7.5	21.9	0.7	-0.5	4.7
Osteoarthritis (self-reported)	1.9	2.5	3.7	1.8	-0.7	-1.9
Eye problems/disorders: Glaucoma	1.9	2.3	5.2	-1.1	2.3	0.7
Ulcerative Colitis (UC)	1.8	3.4	5.9	2.4	2.1	0.4
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	4.8	-2.2	0.8	0.7
Trunk fat percentage	1.8	7.1	20.3	0.3	-0.9	4.5
Chronic bronchitis/emphysema (father)	1.8	2.1	6.1	-0.1	2.5	0.3
Illnesses of mother	1.8	2.3	3.2	1.0	-1.8	-1.6
Eye problems/disorders: None of the above	1.8	2.1	5.6	0.4	-2.4	-0.6
Mouth/teeth dental problems: Loose teeth	1.8	2.2	6.1	0.5	0.5	2.5
Medication: Ibuprofen	1.8	2.2	4.1	1.4	-2.0	-0.7
Had major operations	1.8	2.2	5.1	1.1	2.3	0.3
Commuting to job workplace: Public transport	1.8	2.2	6.0	-2.4	-0.5	-0.6
Medication: Paracetamol	1.8	2.7	6.0	0.8	-2.4	1.3
Vascular/heart problems diagnosed by doctor	1.8	4.8	13.6	0.5	-0.8	-3.7
Past tobacco smoking	1.7	3.1	6.6	2.6	-1.1	-1.2
Arm fat percentage (right)	1.7	6.7	18.4	1.3	-0.1	4.3
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	4.4	2.1	-1.4	0.1
Medication: Paracetamol	1.7	2.7	4.2	0.8	-1.8	2.1
Arm fat percentage (left)	1.7	6.9	19.0	1.3	-0.0	4.4
Angina	1.6	2.0	4.1	2.0	1.4	0.3
Supplements: Glucosamine	1.6	2.1	5.9	2.4	-0.2	-0.6
Medication: Levothyroxine sodium	1.6	2.6	4.1	-1.9	-2.0	0.7
Alcohol usually taken with meals	1.6	2.6	4.6	1.8	2.1	-0.4
Pulse wave reflection index	1.6	1.9	4.3	0.5	1.1	2.1
Loud music exposure frequency	1.6	1.8	3.3	-1.4	-1.8	0.1
Exposure to tobacco smoke outside home	1.6	2.2	5.2	0.3	-1.1	2.3
Alcohol intake frequency.	1.6	3.7	6.1	1.9	-2.5	1.1
Hypertension (Self-reported)	1.6	4.4	12.2	0.4	0.8	3.5
Eye problems/disorders: Cataract	1.6	1.9	4.3	0.5	2.1	1.1
Leg fat percentage (left)	1.6	6.0	17.5	0.6	-0.2	4.2
Ever had prostate specific antigen (PSA) test	1.6	1.9	4.8	0.7	0.6	-2.2
Crohns Disease (2017)	1.5	3.3	6.0	2.4	0.9	1.8
High blood pressure	1.5	4.2	12.4	-0.0	0.5	3.5
Body mass index (BMI)	1.5	6.4	16.2	1.6	-0.6	4.0
Trunk fat mass	1.5	6.3	18.0	0.5	-0.9	4.2
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.6	0.9	2.1	-0.2
Qualifications: nursing, teaching	1.5	2.3	4.8	-1.3	2.2	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	2.0	1.4	1.3	1.2
Medication: Atorvastatin	1.5	1.9	2.7	-1.1	1.6	1.4
Leg fat mass (left)	1.5	6.0	17.6	0.7	-0.3	4.2
Major Depression (MDD)	1.4	1.7	3.5	1.9	0.0	1.2
BMI	1.4	8.2	17.1	2.7	-0.3	4.1
Systolic blood pressure, automated reading	1.4	4.0	6.7	0.8	2.1	2.6
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	4.3	0.8	-2.1	-0.3
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.1	-0.1	1.3	1.7
Angina (self-reported)	1.4	1.8	3.3	1.8	1.3	0.6
Whole body fat mass	1.4	6.0	17.5	0.6	-0.6	4.2
Arm fat mass (left)	1.4	5.7	15.6	1.1	-0.6	4.0
Age started oral contraceptive pill	1.4	1.7	5.0	-0.4	2.2	-0.1
Hearing difficulty/problems: Yes	1.3	1.9	5.6	0.1	2.4	-0.5
Medication: Metformin	1.3	1.9	4.8	-2.2	0.0	-0.9
Stomach or abdominal pain in last month	1.3	1.7	4.1	-0.5	-0.8	-2.0
Had other major operations	1.3	1.6	4.6	-2.1	0.4	0.3
Pulse wave Arterial Stiffness index	1.3	1.5	3.2	-1.1	0.5	1.8
Arm fat mass (right)	1.3	5.5	15.2	1.1	-0.4	3.9
Medication for pain relief, constipation, heartburn	1.3	2.2	3.3	-1.8	0.9	-1.5
Back pain experienced in last month	1.3	1.9	5.0	0.5	-2.2	-0.6
Crohns Disease (2012)	1.2	1.9	3.3	1.2	1.8	0.9
Lupus	1.2	1.8	2.2	1.1	-1.5	1.4
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.3	-1.5	0.7	-1.3
Current tobacco smoking	1.2	2.0	4.8	-2.2	-0.0	-1.1
High blood pressure (mother)	1.2	1.7	2.2	-1.4	0.8	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	4.7	2.2	1.8	0.5
Peak expiratory flow (PEF)	1.2	2.7	7.5	-0.4	0.6	2.7
Leg fat percentage (right)	1.2	4.4	12.7	0.6	0.5	3.6
Leg fat mass (right)	1.2	4.8	14.1	0.6	0.2	3.8
Smoking status: Current	1.2	1.9	5.1	-2.2	0.0	-0.8
Diastolic blood pressure, automated reading	1.2	3.8	8.4	1.6	0.7	2.9
Bipolar Disorder (2018)	1.1	1.7	4.8	-0.3	2.2	-0.3
Mean Putamen Volume	1.1	1.3	3.5	-1.9	-0.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.4	1.5	-0.5	1.1
Wears glasses or contact lenses	1.1	1.3	2.5	-1.6	1.0	0.7
Bipolar Disorder or Schizophrenia	1.0	2.5	4.9	-1.0	2.2	1.2
Alzheimer’s Disease (in father)	1.0	1.1	1.6	-1.2	1.1	0.8
Neuroticism (2016)	1.0	1.5	3.8	-0.7	0.5	1.9
Cardiovascular Disease	1.0	3.3	9.4	-0.6	0.5	3.1
Townsend deprivation index at recruitment	1.0	1.4	3.1	0.0	-1.8	1.1
Average weekly fortified wine intake	1.0	1.1	1.7	1.1	1.3	-0.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	1.8	1.3	-0.5	1.1
Serious illness, injury or assault to yourself	1.0	1.3	1.7	1.3	-1.3	0.7
Financial difficulties in last 2 years	1.0	1.4	2.6	1.2	-1.6	-0.2
Allergy	1.0	2.3	4.3	-1.3	-0.9	-2.1
Pulse wave peak to peak time	1.0	1.2	2.6	0.9	-0.5	-1.6
Medication: Blood pressure	1.0	1.7	2.3	1.4	1.5	1.0
Osteoporosis (self-reported)	1.0	1.2	1.9	-0.2	1.2	-1.4
Myopia	1.0	1.4	4.1	-0.1	-0.4	2.0
Cholesterol lowering medication	1.0	1.5	2.1	-1.4	-1.0	1.2
Taking other prescription medications	0.9	1.5	4.0	-2.0	0.4	-0.4
Heart attack	0.9	1.1	2.3	0.8	-1.5	0.6
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	7.1	-1.0	-1.1	2.7
Tense / ‘highly strung’	0.9	1.5	2.6	0.8	-1.1	-1.6
Medication: Omeprazole	0.9	1.1	3.1	0.4	-0.4	-1.8
Medication: Aspirin	0.9	1.2	1.7	1.3	0.9	1.0
Mood swings	0.9	1.6	4.1	0.7	2.0	0.4
Ever had bowel cancer screening	0.9	1.0	2.5	0.5	1.6	-0.7
Medication: Lisinopril	0.9	1.2	1.7	1.3	-0.2	1.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.2	3.2	-0.2	-0.5	-1.8
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.2	0.3	-1.8	0.3
Schizophrenia (2018)	0.8	1.7	2.9	-1.1	1.1	1.7
Smoking Status	0.8	1.8	4.7	-2.2	0.4	-0.8
Allergy or Eczema	0.8	2.1	5.1	2.3	0.7	-0.7
Medication for hormone replacement therapy	0.8	0.9	1.1	-0.8	1.0	-1.0
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.4	2.1	0.5	0.8
Medication: Atenolol	0.8	1.0	1.4	0.8	-1.2	0.9
Hair/balding pattern: Pattern 2	0.8	1.0	2.0	1.0	-0.1	-1.4
Weight	0.8	3.8	10.4	0.7	-0.8	3.2
Falls in the last year	0.8	1.1	3.3	1.8	0.2	0.0
Happiness	0.8	1.0	2.5	1.6	-0.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.3	0.7	0.8	1.2
Mouth/teeth dental problems: Dentures	0.8	1.4	2.6	-0.8	-1.0	-1.6
Medication: Cholesterol lowering	0.8	1.3	3.7	0.3	1.9	0.4
Blood clot in the leg (DVT)	0.8	1.0	1.8	1.4	-1.0	-0.4
Gout (self-reported)	0.8	1.1	2.9	1.7	-0.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.6	-0.1	0.3	-1.6
Medication: Allopurinol	0.8	1.1	2.8	1.7	-0.3	-0.6
Suffer from ‘nerves’	0.8	1.2	2.6	-0.6	-0.8	-1.6
Tinnitus: Yes, now most or all of the time	0.8	1.0	1.9	-1.4	0.8	0.6
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.0	1.4	-0.9	-0.5
Intelligence (Savage-Jansen 2018)	0.7	2.2	6.3	-0.5	0.4	2.5
Worry (Nagel 2018)	0.7	1.4	3.9	-0.3	0.5	-2.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.7	-0.9	-0.0	1.3
Alzheimer’s Disease (including proxy)	0.7	1.0	1.8	-1.3	1.0	0.2
Bipolar Disorder (2011)	0.7	0.7	1.5	0.2	1.2	0.8
Coronary Artery Disease (CAD)	0.7	0.8	2.3	-0.1	-0.2	1.5
Schizophrenia (2014)	0.7	1.6	1.7	-1.3	1.3	1.3
Triglycerides	0.7	1.1	2.4	-0.0	1.5	1.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.4	-0.7	-0.6	1.2
Respiratory disease	0.7	1.6	4.4	0.4	2.1	0.6
Number of treatments/medications taken	0.7	1.2	2.4	-0.1	-1.6	1.0
Frequency of depressed mood in last 2 weeks	0.7	0.9	1.5	0.0	-1.2	1.1
Relative age of first facial hair	0.7	1.4	3.0	-1.7	0.9	0.5
Impedance of leg (right)	0.7	3.4	9.3	-3.0	0.6	-0.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.1	-0.8	-0.8	1.1
Impedance of leg (left)	0.7	3.6	10.6	-3.3	-0.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.5	0.8	-1.6	0.3
Pulse rate	0.7	1.1	2.3	0.9	-1.5	0.4
Number of full brothers	0.7	0.9	1.3	0.9	-0.7	1.2
Age at first live birth	0.7	1.2	3.0	1.7	0.2	-0.7
Emphysema/chronic bronchitis	0.7	0.8	1.7	0.7	-1.3	-0.1
Mean time to correctly identify matches	0.7	1.3	2.8	0.8	0.8	1.7
Chest pain or discomfort	0.7	1.1	2.3	0.9	-0.2	1.5
Leg pain on walking	0.7	0.9	2.2	-0.7	-1.5	-0.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.3	-1.2	1.1	-0.3
Breast cancer (self-reported)	0.7	0.9	1.3	1.1	-1.2	-0.2
Medication: Aspirin	0.7	0.9	1.3	1.2	0.6	1.1
Illnesses of father: None of the above (group 1)	0.7	0.9	1.8	-0.6	0.7	-1.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.3	-0.1	0.6	1.5
Illnesses of father: High blood pressure	0.7	0.9	1.4	1.1	-1.2	0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.5	4.4	-0.1	0.1	2.1
Chronotype (morning person)	0.6	1.4	3.6	1.9	0.5	-0.7
Pack years adult smoking proportion	0.6	0.9	2.4	-1.5	-0.5	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.7	1.1	1.6	-0.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.6	0.4	1.3	0.6
Qualifications: None of the above	0.6	1.4	3.5	0.3	-1.9	-0.7
Medication: Ramipril	0.6	0.7	2.1	-1.5	-0.2	0.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.2	0.3	2.0	0.3
Length of working week for main job	0.6	0.7	1.2	0.7	-0.7	1.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.7	1.3	0.7	-0.9
Headache pain in last month	0.6	1.1	2.7	-0.7	-1.6	0.0
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.2	-1.0	0.0	1.1
Smoking status: Previous	0.6	0.8	1.1	-0.8	0.9	1.1
Loneliness, isolation	0.6	0.9	1.9	0.6	-1.4	0.6
Asthma (self-reported)	0.6	1.2	1.4	-1.2	1.1	1.0
Mother’s age at death	0.6	0.7	1.9	1.4	0.2	0.4
Supplements: Calcium	0.6	0.6	1.8	-0.3	1.4	-0.2
Alcohol drinker status: Previous	0.6	0.7	1.0	-0.6	-1.0	0.8
Age at First Birth	0.5	0.7	1.5	0.7	1.2	0.2
HDL Cholesterol	0.5	0.9	1.6	-0.5	-1.2	0.9
LDL Cholesterol	0.5	0.8	1.2	1.1	0.5	0.9
Blood Red Count	0.5	5.0	14.3	0.7	-0.4	3.8
Heel T-Score	0.5	3.8	8.8	3.0	1.4	0.9
Systolic Blood Pressure	0.5	2.7	7.3	0.0	0.8	2.7
Severe depression (siblings)	0.5	0.6	1.0	-0.9	-0.2	1.0
Fed-up feelings	0.5	0.8	2.2	-0.1	0.6	1.5
Multivitamins +/- minerals	0.5	0.6	1.7	0.3	-0.1	-1.3
Waist circumference	0.5	1.8	5.2	0.0	-0.4	2.3
Fluid intelligence score	0.5	1.0	1.5	-1.2	-0.2	1.2
Illnesses of siblings	0.5	0.6	1.8	-1.4	-0.2	0.1
Time employed in main current job	0.5	0.6	1.7	-1.3	-0.2	0.2
Worrier / anxious feelings	0.5	1.0	2.6	-0.4	1.6	-0.5
Asthma	0.5	1.0	1.1	-1.0	1.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	2.8	-1.7	-0.6	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.8	0.2	-0.4	1.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.8	-0.7	-1.3	-0.6
Migraine (self-reported)	0.5	0.6	1.7	-0.4	-0.2	1.3
Medication: Seretide 50 evohaler	0.5	0.6	1.4	-0.5	-1.2	0.3
Number of full sisters	0.5	0.6	1.2	-0.7	0.5	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.3	-0.4	0.4	-1.5
Medication: Gliclazide	0.5	0.5	1.0	-0.7	1.0	-0.3
Number of self-reported non-cancer illnesses	0.5	0.9	1.3	-1.1	-0.6	1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.0	-0.1	-1.0	1.0
High cholesterol (Self-reported)	0.5	1.0	2.3	-0.7	0.4	1.5
Medication: Bendroflumethiazide	0.5	0.7	1.4	1.2	-0.3	0.8
Fractured/broken bones in last 5 years	0.5	0.6	1.5	0.4	-0.5	-1.2
Pack years of smoking	0.5	0.7	2.2	-1.5	-0.0	0.1
Impedance of whole body	0.5	2.5	7.0	-2.6	0.4	-0.7
Schizophrenia vs Biploar Disorder	0.4	0.6	1.1	-0.8	-0.1	1.1
Breast Cancer	0.4	0.9	2.7	0.1	1.6	0.2
Lung FVC	0.4	2.0	4.8	-0.4	2.2	1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.0	-1.0	0.2	0.6
Ever had hysterectomy (womb removed)	0.4	0.5	0.8	0.9	0.8	0.2
Hand grip strength (right)	0.4	1.0	2.5	1.6	0.4	-0.7
Relative age voice broke	0.4	0.6	1.6	-0.3	1.2	-0.3
Hearing difficulty/problems with background noise	0.4	0.6	1.7	0.1	1.3	0.0
Had menopause	0.4	0.5	1.0	-0.1	1.0	-0.6
Impedance of arm (right)	0.4	1.8	3.8	-2.0	0.9	-0.9
Hip circumference	0.4	1.5	4.3	0.2	-0.5	2.1
Father’s age at death	0.4	0.5	0.6	0.8	0.7	-0.6
Number of live births	0.4	0.6	0.7	-0.8	-0.8	-0.6
Depression (self-reported)	0.4	0.4	0.8	-0.6	0.9	0.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.7	0.8	0.6	0.6
Medication: Amlodipine	0.4	0.6	1.1	1.0	-0.8	0.2
High blood pressure (siblings)	0.4	0.6	1.6	1.3	0.4	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.4	1.2	-0.2	0.0
Friendships satisfaction	0.4	0.5	1.1	1.1	0.6	0.0
Mineral and other dietary supplements	0.4	0.5	0.7	-0.0	-0.8	-0.9
Financial situation satisfaction	0.4	0.5	0.8	0.5	-0.8	-0.9
Alcohol drinker status: Never	0.4	0.5	0.7	0.8	-0.7	0.5
Number of operations (self-reported)	0.4	0.6	1.3	0.4	1.1	0.5
Irritability	0.4	0.6	1.0	-0.0	1.0	0.9
Risk taking	0.4	0.5	0.9	0.6	-0.6	-0.9
Commuting to job workplace: Cycle	0.4	0.5	1.0	0.2	0.7	-1.0
Reaction Time	0.3	0.7	1.7	0.5	-0.3	1.3
Primary Biliary Cirrhosis	0.3	0.5	1.1	0.3	1.0	-0.5
Neuroticism	0.3	0.8	1.9	-0.6	1.4	-0.3
Hand grip strength (left)	0.3	0.9	1.3	1.1	-0.3	-1.1
Sensitivity / hurt feelings	0.3	0.4	1.2	0.3	-1.1	-0.1
Vitamin and mineral supplements	0.3	0.4	0.8	-0.6	0.1	0.9
Supplements: Zinc	0.3	0.3	0.4	0.6	0.6	-0.4
Nervous feelings	0.3	0.5	1.0	-1.0	-0.4	-0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.9	0.6	-0.3
Alcohol intake versus 10 years previously	0.3	0.4	0.5	-0.7	-0.6	-0.5
Noisy workplace	0.3	0.4	0.7	-0.5	-0.5	0.8
Medication: Lansoprazole	0.3	0.3	0.6	0.3	0.5	0.8
Impedance of arm (left)	0.3	1.5	3.8	-2.0	0.5	-0.6
Birth weight	0.3	0.7	1.1	-1.1	0.9	0.4
Forced vital capacity (FVC), Best measure	0.3	1.1	3.2	-1.8	0.1	-0.1
Comparative body size at age 10	0.3	0.8	1.3	1.1	0.4	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.7	0.6	0.8	0.0
Number of children fathered	0.3	0.4	1.1	-1.0	0.2	-0.3
Health satisfaction	0.3	0.5	1.0	1.0	-0.3	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	0.8	-0.5	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.9	0.1	0.3	-0.9
Illnesses of siblings: Diabetes	0.3	0.4	0.9	-1.0	0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.2	-0.6	-0.1	-1.1
Long-standing illness, disability or infirmity	0.3	0.4	1.1	-0.3	-1.0	-0.3
Guilty feelings	0.3	0.5	0.6	0.6	0.8	0.6
Ever taken oral contraceptive pill	0.3	0.3	0.7	0.9	0.4	0.3
Arm fat-free mass (left)	0.3	1.4	1.6	1.2	-1.2	1.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.1	0.4	1.0	-0.2
Neuroticism (Nagel 2018)	0.2	0.4	0.7	0.0	0.7	-0.8
Blood White Count	0.2	1.4	2.9	-1.1	0.1	1.7
Average weekly spirits intake	0.2	0.3	0.6	0.8	-0.4	0.1
Leg fat-free mass (left)	0.2	1.1	1.5	1.2	-0.5	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	0.7	-0.6	-0.1
Age when periods started (menarche)	0.2	0.6	1.1	-0.4	-0.6	-1.1
Leg predicted mass (left)	0.2	1.1	1.6	1.2	-0.4	1.2
Medication: Simvastatin	0.2	0.3	0.7	-0.3	-0.1	-0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	-0.6	0.6	-0.2
Lung cancer (father)	0.2	0.3	0.3	-0.5	0.6	0.5
Birth weight of first child	0.2	0.4	0.6	-0.6	0.8	0.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	-0.7	0.8	0.1
Arm predicted mass (right)	0.2	0.9	1.2	0.8	-1.0	1.1
Pulse rate, automated reading	0.2	0.5	0.6	0.8	-0.8	0.6
Age at last live birth	0.2	0.4	0.6	0.6	-0.8	-0.3
Supplements: Vitamin C	0.2	0.2	0.7	-0.2	0.2	0.8
Leg fat-free mass (right)	0.2	1.3	1.6	1.2	-0.9	1.3
Leg predicted mass (right)	0.2	1.2	1.6	1.1	-0.9	1.3
Basal metabolic rate	0.2	1.2	1.5	1.1	-0.9	1.2
Heart disease (siblings)	0.2	0.2	0.4	0.1	-0.6	0.6
Arm predicted mass (left)	0.2	1.1	1.3	1.0	-1.0	1.1
Depression (Nagel 2018)	0.1	0.2	0.5	0.3	-0.7	-0.0
Rheumatoid Arthritis	0.1	0.2	0.3	0.1	-0.5	-0.5
Blood Platelet Count	0.1	0.6	0.7	-0.8	0.8	-0.7
Height	0.1	2.5	7.1	-2.7	0.7	-0.1
Waist Hip Ratio (WHR)	0.1	0.2	0.5	-0.7	0.3	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.4	-0.1	-0.4
Tanning	0.1	0.8	1.5	0.8	1.2	-0.4
Diabetes (father)	0.1	0.1	0.2	0.3	-0.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.1	-0.7	0.4
Forced vital capacity (FVC)	0.1	0.5	0.8	-0.9	0.1	0.8
Pain all over the body in last month	0.1	0.1	0.2	0.4	0.1	-0.1
Diabetes (self-reported)	0.1	0.2	0.4	-0.3	0.1	-0.6
Neuroticism score	0.1	0.1	0.2	-0.2	0.5	0.4
Trunk fat-free mass	0.1	0.5	1.2	1.1	-0.6	0.2
Trunk predicted mass	0.1	0.6	1.3	1.2	-0.6	0.1
Standing height	0.1	1.4	3.0	-1.7	-0.4	-1.0
Breastfed as a baby	0.1	0.2	0.5	0.2	0.0	0.7
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	0.1	-0.8	0.0
Arm fat-free mass (right)	0.1	0.7	0.8	0.9	-0.7	0.9
Comparative height size at age 10	0.1	0.3	0.5	-0.7	0.5	-0.3
Illnesses of father: Heart disease	0.1	0.2	0.2	-0.4	-0.3	0.5
Whole body fat-free mass	0.1	0.7	1.3	1.1	-0.6	0.6
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.6	-0.0	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.2	0.0	0.5	0.4
Whole body water mass	0.1	0.8	1.7	1.3	-0.7	0.6
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.1	-0.4	-0.6
Miserableness	0.1	0.2	0.5	-0.7	0.5	0.1
Hearing aid user	0.1	0.1	0.2	0.4	0.2	-0.1
Blood Eosinophil Count	0.0	0.3	0.7	-0.4	-0.9	0.0
Hair Pigment	0.0	0.7	0.9	-0.9	0.6	-1.0
Sitting height	0.0	0.1	0.2	-0.3	-0.4	-0.0
Mouth/teeth dental problems	0.0	0.0	0.1	0.4	0.0	-0.1
Worry too long after embarrassment	0.0	0.1	0.2	-0.0	-0.0	0.4
Family relationship satisfaction	0.0	0.1	0.1	0.4	-0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.1	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.0	0.0	0.2	0.2

Hub : Genes

NTM

Models

Trait associations