TWAS hub - NUFIP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0413	0.0200	2.3e-03	0.036	0.019	0.019	0.019	0.025	3.7e-06	6.2e-04	5.5e-04	6.9e-04	1.1e-04
2	NTR	Blood	0.0176	0.0089	1.8e-03	0.006	0.005	0.010	0.007	0.009	4.8e-03	9.1e-03	2.5e-04	1.3e-03	5.8e-04
3	YFS	Blood	0.0735	0.0176	1.2e-14	0.046	0.056	0.058	0.055	0.060	7.7e-15	9.2e-18	1.8e-18	1.7e-17	5.8e-19

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Platelet Count	17.1	198.3	364.8	14.6	19.1	-4.1
Mouth/teeth dental problems	8.1	12.4	17.7	2.1	4.2	-3.9
Fasting Glucose	7.2	8.6	12.5	3.1	3.5	-2.0
Heart disease (siblings)	6.5	8.0	15.6	-0.3	-2.9	4.0
Wheeze or whistling in the chest in last year	6.4	11.4	15.4	-2.5	-3.5	3.9
Qualifications: NVQ or HND or HNC or equivalent	6.3	7.6	10.1	-2.3	-3.2	2.7
Eye problems/disorders: Cataract	5.9	6.9	12.1	3.5	2.9	-0.2
Hypothyroidism (self reported)	5.8	13.3	22.5	-4.7	-3.7	-2.0
Townsend deprivation index at recruitment	5.7	8.1	14.0	-2.3	-3.7	2.2
Alcohol intake versus 10 years previously	5.7	8.5	12.9	-2.5	-3.6	2.5
Risk taking	5.7	8.3	11.0	-3.1	-3.3	2.0
Asthma	5.5	10.8	19.2	-4.4	-3.5	0.8
Hypothyroidism/myxoedema (self-reported)	5.5	10.7	19.0	-4.4	-3.2	-1.6
Current tobacco smoking	5.4	8.9	19.0	-0.7	-2.7	4.4
Smoking status: Current	5.4	8.5	19.2	-0.7	-2.4	4.4
Asthma (self-reported)	5.3	10.6	17.5	-4.2	-3.6	1.2
Medication: Lisinopril	5.2	6.7	14.0	3.7	2.5	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	5.0	6.7	10.4	-2.7	-3.2	1.5
Pain all over the body in last month	5.0	5.3	8.3	-2.9	-2.7	0.5
Wears glasses or contact lenses	5.0	5.7	8.2	2.1	2.9	-2.1
Prostate Cancer	4.9	7.0	14.7	2.0	3.8	-1.4
Eye problems/disorders: None of the above	4.9	5.7	8.8	-3.0	-2.7	0.9
Friendships satisfaction	4.9	6.1	10.3	-2.2	-3.2	1.8
Pack years adult smoking proportion	4.7	7.1	10.8	-1.6	-3.3	2.9
Medication: Gliclazide	4.7	5.3	9.9	2.5	3.1	0.0
Unable to work because of sickness or disability	4.6	5.9	8.9	-3.0	-3.0	0.3
Age at First Birth	4.5	6.5	8.1	2.7	2.8	-2.0
Smoking Status	4.5	10.9	20.7	-1.1	-3.3	4.5
Happiness	4.4	5.3	8.6	-1.5	-2.3	2.9
Number of full sisters	4.4	5.4	9.1	-2.5	-3.0	0.8
Age started oral contraceptive pill	4.4	5.6	7.1	2.7	2.6	1.6
Pack years of smoking	4.4	6.5	9.8	-1.0	-2.9	3.1
Alcohol intake frequency.	4.2	9.7	16.5	-2.9	-4.1	2.0
Diabetes diagnosed by doctor	4.2	6.9	12.5	1.8	3.5	-2.2
Other serious medical condition/disability diagnosed by doctor	4.1	5.4	5.7	-2.3	-2.4	2.3
Medication: Metformin	4.0	5.7	11.4	2.1	3.4	-1.2
Number of full brothers	4.0	5.0	7.7	-1.5	-2.8	2.2
Alcohol drinker status: Previous	4.0	4.6	6.9	-1.7	-2.0	2.6
Headache pain in last month	3.9	6.7	12.4	-1.5	-3.5	2.4
Supplements: Glucosamine	3.8	5.0	8.4	1.8	2.9	-1.8
Pain type(s) experienced in last month: Hip pain	3.8	4.8	6.5	-1.8	-2.5	2.2
Lung FVC	3.7	19.0	46.9	0.2	-3.2	6.8
High cholesterol (Self-reported)	3.6	6.4	13.3	1.1	-2.1	3.7
Ovarian Cancer	3.5	4.6	10.0	3.2	1.3	1.4
Type 2 Diabetes (T2D) (2018)	3.5	6.6	11.1	1.9	3.3	-2.3
Medication: Levothyroxine sodium	3.5	5.9	11.0	-3.3	-2.6	-0.4
Gout (self-reported)	3.5	4.8	11.1	-0.7	1.7	-3.3
Depression (Nagel 2018)	3.4	5.1	7.3	-2.7	-2.7	1.0
Supplements: Vitamin C	3.4	4.1	6.9	2.3	2.6	0.5
Tinnitus: Yes, now most or all of the time	3.4	4.0	5.5	-1.6	-2.3	2.0
Myopia	3.2	4.6	7.1	-2.7	-2.6	0.4
Mother’s age at death	3.1	3.9	6.2	2.5	2.0	-1.2
Frequency of depressed mood in last 2 weeks	3.0	4.2	6.4	-2.5	-2.5	0.1
Medication: Lansoprazole	3.0	3.4	5.3	2.2	2.3	0.6
Supplements: Fish oil (including cod liver oil)	3.0	3.9	6.2	1.8	2.5	-1.6
Maternal smoking around birth	2.9	4.2	8.1	-1.7	-2.8	1.4
Fed-up feelings	2.9	5.3	8.4	-2.6	-2.9	-0.8
Impedance of arm (right)	2.9	13.7	32.8	0.0	2.9	-5.7
Impedance of arm (left)	2.9	13.4	33.2	0.1	2.7	-5.8
Shortness of breath walking on level ground	2.9	3.4	5.1	-1.5	-2.2	1.7
Loneliness, isolation	2.9	4.0	6.4	-2.3	-2.5	0.4
Medication for cholesterol	2.9	4.4	8.8	-2.1	0.1	-3.0
Ulcerative Colitis	2.8	4.0	4.8	2.2	2.1	-1.7
Miserableness	2.8	4.9	8.5	-2.5	-2.9	-0.1
Cholesterol lowering medication	2.8	4.1	8.8	1.6	-1.0	3.0
Basal cell carcinoma (self-reported)	2.8	3.3	4.4	1.7	2.1	1.5
Mean Putamen Volume	2.7	3.1	4.1	1.7	1.6	2.0
Rheumatoid Arthritis	2.7	3.7	6.9	-2.0	-2.6	0.2
Respiratory disease	2.6	5.8	9.1	-3.0	-2.8	0.7
Vitamin and mineral supplements	2.6	3.6	5.9	-2.1	-2.4	-0.5
Mouth/teeth dental problems: Dentures	2.6	4.4	6.2	-1.6	-2.5	2.1
Medication: Aspirin	2.6	3.4	6.0	2.5	1.5	1.4
Hand grip strength (right)	2.5	6.9	9.3	3.1	1.6	3.0
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	6.0	-1.9	-2.4	1.6
Noisy workplace	2.5	3.1	6.5	-0.5	-1.6	2.6
Knee pain experienced in last month	2.5	4.0	5.9	-1.2	-2.4	2.1
Mood swings	2.5	4.5	9.3	-1.9	-3.0	0.9
Mineral and other dietary supplements	2.5	3.4	6.2	-1.9	-2.5	0.7
Pain experienced in last month	2.5	4.1	7.1	0.9	2.7	-2.1
Diabetes (father)	2.4	3.0	7.2	0.9	2.7	-0.9
Age at first live birth	2.4	4.3	6.9	1.3	2.6	-2.1
Mean time to correctly identify matches	2.4	4.6	9.3	3.0	2.0	-0.7
Chest pain or discomfort	2.4	3.5	5.9	-1.6	-2.4	1.4
Ever depressed for a whole week	2.4	3.0	6.4	-2.5	-1.6	0.0
Birth weight of first child	2.3	4.2	8.1	2.8	2.1	0.5
Mouth/teeth dental problems: Loose teeth	2.3	2.7	4.6	-1.1	-2.1	1.6
Overall health rating	2.3	5.0	8.1	-1.6	-2.8	2.1
Medication: Bendroflumethiazide	2.3	3.5	8.7	2.9	1.4	-0.1
Waist Hip Ratio (WHR)	2.2	9.7	17.6	3.3	4.2	-0.9
Financial difficulties in last 2 years	2.2	3.0	4.4	-1.3	-2.1	1.7
Ever had prostate specific antigen (PSA) test	2.2	2.6	4.9	0.7	1.5	-2.2
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	6.1	-0.5	-1.3	2.5
Guilty feelings	2.1	3.2	6.3	-2.5	-1.3	-1.3
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.9	-0.6	-0.8	2.4
High blood pressure	2.0	5.6	12.7	3.6	1.7	1.2
Peak expiratory flow (PEF)	2.0	4.6	8.6	2.9	2.3	-0.1
Birth weight	2.0	4.4	8.2	1.6	2.9	-1.5
Comparative height size at age 10	2.0	11.2	21.6	2.4	4.7	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	4.2	2.0	1.5	0.7
Body Mass Index (BMI) (2010)	1.9	2.5	5.1	1.5	2.3	-0.6
Had other major operations	1.9	2.4	5.6	0.1	-1.2	2.4
Allergy	1.9	4.3	6.4	2.5	2.1	-1.4
Qualifications: A levels/AS levels or equivalent	1.9	4.1	6.5	0.7	2.5	-2.3
Medication: Allopurinol	1.9	2.5	6.7	-0.6	0.6	-2.6
Commuting to job workplace: Cycle	1.9	2.3	4.1	-1.2	-1.2	2.0
Medication: Aspirin	1.8	2.4	3.9	2.0	1.3	1.3
Alzheimer’s Disease (in mother)	1.7	2.0	4.8	-2.2	-1.2	-0.0
Hand grip strength (left)	1.7	4.4	8.2	2.2	0.4	2.9
Medication for hormone replacement therapy	1.7	1.9	2.0	1.3	1.4	1.4
Medication: Co-codamol	1.7	2.0	4.0	0.2	-1.4	2.0
Serious illness, injury or assault to yourself	1.7	2.0	4.2	-1.2	-0.7	2.0
Falls in the last year	1.7	2.3	4.1	-0.7	-1.5	2.0
Ever highly irritable/argumentative for 2 days	1.7	2.1	5.1	-2.3	-1.1	-0.1
Medication: Blood pressure	1.7	3.1	6.9	2.6	1.4	-0.5
Hypertension (Self-reported)	1.7	4.7	10.9	3.3	1.4	1.1
Handedness (chirality/laterality): Left-handed	1.7	2.1	3.5	0.4	1.6	-1.9
Long-standing illness, disability or infirmity	1.7	2.6	4.5	-0.4	-1.8	2.1
HbA1C	1.6	1.7	2.2	0.9	1.5	-1.5
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.5	-1.9	-1.4	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	4.0	-0.1	1.1	-2.0
Medication: Atorvastatin	1.6	2.0	3.9	2.0	1.4	-0.3
Impedance of whole body	1.6	8.3	20.9	-0.4	2.0	-4.6
Heel T-Score	1.5	11.8	22.5	3.5	4.7	0.8
Diabetes (self-reported)	1.5	2.2	3.8	0.8	1.9	-1.5
Leg pain on walking	1.5	1.9	5.4	0.5	0.1	2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	4.7	-0.2	-0.3	2.2
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	3.3	-1.2	-1.8	1.5
Diabetes (mother)	1.4	1.8	1.9	1.4	1.3	-1.3
Severe depression (siblings)	1.4	1.6	4.1	-0.2	-0.8	2.0
Alcohol usually taken with meals	1.4	2.2	4.0	0.6	1.5	-2.0
Hearing difficulty/problems with background noise	1.4	2.3	3.3	-1.3	-1.4	1.8
Exposure to tobacco smoke at home	1.4	1.6	4.1	-0.8	-2.0	-0.1
Comparative body size at age 10	1.4	3.8	6.9	2.6	1.6	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	2.6	0.5	1.4	-1.6
Health satisfaction	1.4	1.8	3.4	-0.8	-1.9	1.1
Medication: Paracetamol	1.4	2.2	4.4	-0.6	-2.1	1.4
Alcohol drinker status: Never	1.4	1.7	3.1	-1.3	-1.8	0.4
Depressed Affect (Nagel 2018)	1.3	2.8	5.8	-1.6	-2.4	-0.0
Cardiovascular Disease	1.3	4.1	9.5	3.1	0.9	1.5
Waist circumference	1.3	4.6	9.0	3.0	2.1	0.8
Nervous feelings	1.3	2.4	6.2	1.0	2.5	-0.2
Heart attack	1.3	1.7	3.3	-0.4	-1.8	1.3
Medication: Simvastatin	1.3	2.0	4.0	0.4	-1.3	2.0
Family relationship satisfaction	1.3	1.6	4.3	0.8	-0.0	2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	4.3	1.6	2.1	-1.2
Average weekly red wine intake	1.3	1.9	4.0	-1.0	0.8	-2.0
Fractured/broken bones in last 5 years	1.3	1.6	2.0	-1.3	-1.4	1.1
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.5	1.9	0.9	0.7
Lupus	1.2	1.9	3.7	-1.9	-1.4	-0.0
Neuroticism (2016)	1.2	1.7	3.9	-2.0	-0.8	-0.7
Systolic blood pressure, automated reading	1.2	3.5	5.7	2.1	2.4	-0.5
Angina	1.2	1.5	3.0	-1.2	-1.7	0.3
Supplements: Zinc	1.2	1.3	2.2	0.4	1.3	1.5
Average weekly fortified wine intake	1.2	1.4	2.2	0.9	1.5	-1.0
Taking other prescription medications	1.2	1.8	2.5	-0.8	-1.5	1.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.4	1.8	0.3	0.7
Depression (self-reported)	1.2	1.4	4.0	-0.5	0.0	2.0
Standing height	1.2	11.9	18.2	2.2	4.3	-3.6
Angina (self-reported)	1.2	1.5	2.7	-1.4	-1.6	0.0
Ulcerative Colitis (UC)	1.1	2.0	3.2	1.4	1.8	-1.0
LDL Cholesterol	1.1	1.7	3.5	-0.1	-1.9	1.3
Blood White Count	1.1	7.9	22.8	-0.9	0.5	-4.8
Stomach or abdominal pain in last month	1.1	1.4	2.3	-0.4	-1.3	1.5
Prospective memory result	1.1	1.4	1.6	-1.0	-1.3	1.3
Lung cancer (father)	1.1	1.3	3.0	1.0	1.7	0.1
Loud music exposure frequency	1.1	1.2	2.4	1.0	0.1	1.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.0	-0.3	-0.9	1.7
Medication: Seretide 50 evohaler	1.1	1.3	2.1	-1.5	-1.2	0.4
Back pain experienced in last month	1.1	1.6	3.3	0.3	-1.1	1.8
Financial situation satisfaction	1.1	1.3	2.9	-0.8	-1.7	0.6
Eye problems/disorders: Glaucoma	1.1	1.3	2.7	1.7	0.7	0.8
Vascular/heart problems diagnosed by doctor	1.1	3.1	7.7	-2.8	-1.1	-0.7
Supplements: Calcium	1.1	1.3	2.5	-0.7	-0.9	1.6
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.1	-0.6	-1.8	0.9
Multivitamins +/- minerals	1.0	1.2	2.6	0.8	1.6	-0.6
Chronic bronchitis/emphysema (father)	1.0	1.2	1.8	-0.1	-1.3	-1.3
Number of incorrect matches in round	1.0	1.6	2.7	1.2	1.6	0.8
Number of live births	1.0	1.4	2.7	-1.6	-1.2	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.3	-1.5	-1.0	0.7
Pulse wave peak to peak time	1.0	1.1	2.5	0.8	0.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	5.3	1.0	0.2	2.3
Average weekly champagne plus white wine intake	1.0	1.4	2.0	1.3	1.4	-0.7
Ever taken oral contraceptive pill	1.0	1.2	2.6	-0.9	-0.2	-1.6
Hearing aid user	1.0	1.2	1.8	-1.3	-0.4	-1.3
Medication: Blood pressure	1.0	2.0	5.0	2.2	0.7	0.5
Irritable Bowel Disease (IBD)	0.9	2.2	4.1	1.3	2.0	-0.8
Type 2 Diabetes (T2D) (2012)	0.9	1.1	3.1	0.3	1.8	-0.0
Past tobacco smoking	0.9	1.6	4.0	-0.0	0.8	-2.0
Qualifications: College or University degree	0.9	2.7	4.2	1.0	2.1	-1.7
Pulse rate, automated reading	0.9	2.9	7.0	-1.3	0.1	2.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.1	1.5	0.9	0.2
Blood Eosinophil Count	0.8	6.4	11.2	-2.8	-3.3	-0.5
Height	0.8	16.0	32.7	1.3	3.7	-5.7
Allergy or Eczema	0.8	2.2	3.9	-2.0	-1.6	0.2
Relative age of first facial hair	0.8	1.7	2.8	1.7	0.0	1.5
Ever had hysterectomy (womb removed)	0.8	0.9	2.1	-0.7	-0.1	1.5
Medication: Atenolol	0.8	1.0	1.9	1.4	1.0	-0.4
Medication: Paracetamol	0.8	1.3	2.2	0.1	-1.3	1.5
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	3.3	-1.8	-0.9	0.1
Neck or shoulder pain in last month	0.8	1.2	2.5	0.0	-1.0	1.6
Bipolar Disorder (2018)	0.7	1.0	2.1	-1.5	-0.8	-0.6
Worry (Nagel 2018)	0.7	1.5	4.3	0.5	2.1	0.1
Alzheimer’s Disease (including proxy)	0.7	1.0	1.7	-1.3	-1.1	-0.1
Major Depression (MDD)	0.7	0.9	1.8	-1.4	-0.7	0.5
Breast Cancer	0.7	1.7	3.3	1.8	1.3	0.1
Systolic Blood Pressure	0.7	3.6	5.0	2.0	2.2	-1.3
Hearing difficulty/problems: Yes	0.7	1.1	2.7	-1.6	-0.6	-0.5
Time employed in main current job	0.7	0.8	2.0	1.4	0.7	0.1
Pulse wave Arterial Stiffness index	0.7	0.8	1.8	-0.8	-0.2	1.3
Length of working week for main job	0.7	0.8	1.5	-1.2	-0.7	-0.6
Pulse wave reflection index	0.7	0.9	1.4	0.3	-1.0	1.2
Exposure to tobacco smoke outside home	0.7	0.9	2.5	-0.4	-1.6	0.3
Number of children fathered	0.7	0.8	2.1	0.1	-0.4	-1.4
Osteoporosis (self-reported)	0.7	0.9	1.9	0.6	0.7	1.4
Chronotype (morning person)	0.6	1.4	1.8	1.1	1.3	-1.1
Sensitivity / hurt feelings	0.6	0.9	2.6	-1.6	-0.2	0.5
Impedance of leg (right)	0.6	3.1	7.7	-1.2	0.3	-2.8
Body mass index (BMI)	0.6	2.7	6.0	1.3	-0.8	2.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.5	-0.9	-0.5	1.2
Medication: Ramipril	0.6	0.7	1.2	1.0	0.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.0	1.4	0.5	-0.4
Medication for pain relief, constipation, heartburn	0.6	1.1	2.0	-1.4	0.5	-1.0
Medication: Omeprazole	0.6	0.7	1.3	0.6	-0.5	1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.1	1.1	0.9	-0.3
Qualifications: nursing, teaching	0.6	1.0	2.4	0.7	1.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.5	1.2	-0.0	0.7
Breast cancer (self-reported)	0.6	0.7	1.7	-0.2	-0.6	1.3
Average weekly beer plus cider intake	0.6	0.9	1.6	-1.0	-1.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.1	-0.5	-1.0	1.0
Reaction Time	0.5	1.0	1.9	1.4	0.6	-0.8
Bipolar Disorder (2011)	0.5	0.5	1.2	-1.1	0.0	-0.5
Schizophrenia (2014)	0.5	1.0	2.5	0.4	0.6	1.6
Number of treatments/medications taken	0.5	1.0	1.9	0.2	-1.0	1.4
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.2	-1.5	-0.8	0.3
Impedance of leg (left)	0.5	2.5	5.9	-0.5	1.1	-2.4
Trunk fat mass	0.5	2.4	5.2	2.3	1.3	-0.3
Had menopause	0.5	0.6	1.6	1.3	0.4	-0.2
Forced vital capacity (FVC)	0.5	1.9	4.9	0.9	-0.2	2.2
Qualifications: None of the above	0.5	1.0	1.5	0.1	-1.2	1.2
Fluid intelligence score	0.5	1.0	1.3	1.1	0.7	-1.2
Pulse rate	0.5	0.8	1.2	-1.1	-0.5	1.0
Arm fat mass (right)	0.5	1.9	4.4	2.1	0.6	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.4	-1.2	-0.3	1.0
Blood clot in the leg (DVT)	0.5	0.6	0.9	-0.6	-0.8	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.4	0.5	0.4	-1.2
Age at last live birth	0.5	0.7	1.7	0.0	1.3	-0.6
Ever had bowel cancer screening	0.5	0.6	1.0	0.8	0.5	-1.0
Number of self-reported non-cancer illnesses	0.5	1.0	1.1	-0.8	-1.1	1.1
Commuting to job workplace: Public transport	0.5	0.6	1.3	-0.7	-1.2	-0.2
Ever smoked	0.5	0.9	2.0	0.3	-0.8	1.4
Leg fat percentage (left)	0.5	1.9	2.9	1.7	-0.3	1.7
Arm fat-free mass (left)	0.5	2.4	5.8	1.2	-0.1	2.4
Number of operations (self-reported)	0.5	0.7	1.2	0.9	-0.3	1.1
Diastolic blood pressure, automated reading	0.5	1.7	4.9	0.3	0.1	2.2
Arm predicted mass (left)	0.5	2.3	5.2	1.3	0.1	2.3
Neuroticism (Nagel 2018)	0.4	0.9	1.8	-1.3	-0.7	-0.7
Schizophrenia (2018)	0.4	0.8	2.0	-0.4	0.2	1.4
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	0.6	0.9	0.6
Primary Biliary Cirrhosis	0.4	0.6	0.7	-0.8	-0.9	-0.7
Blood Red Count	0.4	4.0	6.1	-1.1	-2.5	2.2
BMI	0.4	2.3	5.2	0.5	-1.2	2.3
Neuroticism	0.4	0.9	1.9	-1.4	-1.0	0.0
Trunk fat percentage	0.4	1.8	3.9	2.0	1.0	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.8	1.1	1.3	-0.1
Qualifications: CSEs or equivalent	0.4	0.5	1.0	0.1	1.0	0.6
Sitting height	0.4	2.6	5.9	-1.2	0.6	-2.4
Neuroticism score	0.4	0.9	2.3	-1.5	-0.6	-0.1
Weight	0.4	2.0	4.3	2.1	1.1	0.7
Hair/balding pattern: Pattern 3	0.4	0.5	1.2	0.5	-0.5	1.1
Tense / ‘highly strung’	0.4	0.6	1.1	0.2	0.8	1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.1	-0.1	1.0	1.0
High blood pressure (siblings)	0.4	0.6	0.7	-0.8	0.7	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.4	3.6	0.6	-0.5	1.9
Leg fat percentage (right)	0.4	1.4	2.0	1.2	-0.8	1.4
Heart disease (mother)	0.4	0.4	0.7	0.1	-0.9	0.7
Whole body fat mass	0.4	1.8	4.2	2.1	1.0	0.3
Arm predicted mass (right)	0.4	2.1	5.4	0.9	-0.2	2.3
Suffer from ‘nerves’	0.4	0.6	0.9	0.8	0.9	-0.5
Had major operations	0.4	0.5	0.8	0.9	0.0	-0.9
Smoking status: Previous	0.4	0.6	1.1	0.7	-0.2	1.1
Arm fat mass (left)	0.4	1.7	3.8	1.9	0.3	1.2
Leg fat mass (left)	0.4	1.4	2.7	1.6	0.1	1.2
Bipolar Disorder or Schizophrenia	0.3	0.7	1.6	-1.3	-0.3	0.7
Crohns Disease (2017)	0.3	0.8	1.5	0.5	1.2	-0.7
Lung FEV1/FVC ratio	0.3	1.3	2.0	1.4	1.3	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	-0.3	-1.0	0.4
Arm fat percentage (right)	0.3	1.1	3.0	1.7	0.5	0.3
Trunk fat-free mass	0.3	1.8	2.4	1.6	1.2	1.3
Hip circumference	0.3	1.3	3.0	1.7	0.9	0.1
Father’s age at death	0.3	0.4	0.7	0.5	0.6	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.9	1.2	0.1	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.6	0.9	-0.3	1.2
Trunk predicted mass	0.3	1.8	2.5	1.6	1.2	1.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	-0.7	0.8	0.2
Body fat percentage	0.3	1.2	3.1	1.8	0.6	-0.1
Arm fat-free mass (right)	0.3	1.8	4.3	1.0	-0.0	2.1
Emphysema/chronic bronchitis	0.3	0.4	0.7	-0.1	-0.7	0.8
Leg fat mass (right)	0.3	1.1	2.3	1.5	-0.1	1.0
Arm fat percentage (left)	0.3	1.1	3.0	1.7	0.5	0.2
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.1	1.0	0.7	0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.2	-0.7	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.4	0.3	-0.0	-1.2
HDL Cholesterol	0.2	0.4	1.0	0.4	1.0	-0.1
Hair Pigment	0.2	6.9	15.6	-0.5	-2.2	4.0
Tanning	0.2	1.9	3.1	-1.6	-1.8	-0.1
Relative age voice broke	0.2	0.3	0.6	0.5	-0.4	0.8
Age when periods started (menarche)	0.2	0.6	1.2	-0.0	-0.8	-1.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.2	-0.7	-0.4
High blood pressure (mother)	0.2	0.3	0.5	0.7	-0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	0.3	0.6	1.1
Illnesses of siblings	0.2	0.3	0.4	0.7	0.2	-0.6
Worrier / anxious feelings	0.2	0.5	1.3	0.1	1.2	-0.2
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.6	-0.7	-0.3
Illnesses of mother	0.2	0.3	0.7	0.3	0.8	-0.2
Breastfed as a baby	0.2	0.2	0.6	-0.1	-0.0	0.8
Glaucoma (self-reported)	0.2	0.3	0.5	0.7	0.3	-0.4
Medication: Amlodipine	0.2	0.2	0.5	0.2	-0.4	-0.7
Worry too long after embarrassment	0.2	0.3	0.8	-0.9	-0.4	-0.1
Medication: Ibuprofen	0.2	0.2	0.5	0.0	-0.7	-0.4
Illnesses of siblings: Diabetes	0.2	0.3	0.8	-0.1	0.9	-0.1
Whole body fat-free mass	0.2	1.2	1.9	1.4	0.8	1.0
Leg fat-free mass (right)	0.2	1.0	2.2	1.5	0.9	0.3
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.4	0.5	-0.3
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.1	-0.6	0.6
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	-0.3	-0.1	0.9
Whole body water mass	0.2	1.2	1.7	1.3	0.6	1.2
Leg predicted mass (right)	0.2	0.9	2.0	1.4	0.8	0.4
Basal metabolic rate	0.2	1.3	2.4	1.6	0.7	1.0
Crohns Disease (2012)	0.1	0.2	0.6	-0.1	0.2	-0.8
Triglycerides	0.1	0.1	0.1	0.3	-0.3	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.0	-0.5	0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.2	-0.3	-0.3	0.5
Leg fat-free mass (left)	0.1	0.5	1.3	1.1	0.4	0.1
Leg predicted mass (left)	0.1	0.5	1.3	1.2	0.5	0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	0.6	0.2	-0.7
Migraine (self-reported)	0.1	0.1	0.2	-0.2	-0.4	-0.3
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.5	-0.1	-0.4
Irritability	0.1	0.2	0.3	0.4	0.1	-0.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.1	0.2	0.0
Average weekly spirits intake	0.0	0.0	0.1	0.3	-0.2	0.0
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.2	0.1	-0.0
Illnesses of father: Heart disease	0.0	0.0	0.1	0.3	0.1	0.0

Hub : Genes

NUFIP2

Models

Trait associations