Hub : Genes

OLFM2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1620	0.0370	1.7e-07	0.089	0.060	0.072	0.071	0.081	5.6e-11	8.8e-08	4.6e-09	5.3e-09	3.9e-10
2	GTEx	Adrenal Gland	0.1492	0.0670	7.7e-03	-0.007	NA	-0.004	NA	0.001	6.8e-01	NA	5.0e-01	NA	3.0e-01
3	GTEx	Thyroid	0.1680	0.0590	3.7e-03	0.089	NA	0.080	NA	0.076	2.5e-07	NA	1.0e-06	NA	1.9e-06
4	ROSMAP	Brain Pre-frontal Cortex	0.2299	0.0479	2.7e-10	0.095	0.091	0.105	0.112	0.088	3.6e-12	8.6e-12	2.1e-13	2.8e-14	2.4e-11
5	TCGA	Breast Invasive Carcinoma	0.0323	0.0126	4.7e-08	0.041	0.041	0.034	NA	0.039	6.2e-09	6.7e-09	1.1e-07	NA	1.6e-08
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1680	0.0600	7.1e-05	0.074	0.077	0.066	NA	0.051	4.9e-05	3.7e-05	1.2e-04	NA	7.1e-04
7	TCGA	Thyroid Carcinoma	0.1380	0.0620	8.5e-03	0.037	0.004	0.019	NA	0.018	1.5e-04	1.2e-01	4.8e-03	NA	6.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.7	1.1	3.5	0.8	-0.6	0.0	-0.3	-1.7	-1.9	0.0
Bipolar Disorder or Schizophrenia	0.4	0.9	2.5	1.4	-0.3	1.6	0.6	-0.5	-0.3	1.0
Depressed Affect (Nagel 2018)	0.3	0.6	1.8	0.8	-0.2	-1.4	0.0	1.1	-0.2	-0.3
Depression (Nagel 2018)	0.6	0.8	4.2	2.0	0.3	-0.8	0.7	0.7	0.3	-0.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.7	-0.3	0.7	1.4	0.8	-1.6	-0.3	-0.3
Neuroticism (Nagel 2018)	0.3	0.8	1.8	1.2	1.2	-0.4	-0.4	1.3	0.8	0.0
Schizophrenia (2018)	0.7	1.5	4.9	1.0	0.3	2.2	1.0	0.9	1.0	1.3
Schizophrenia vs Biploar Disorder	0.2	0.2	0.8	0.9	-0.8	0.0	0.5	0.0	0.0	0.0
Worry (Nagel 2018)	0.6	1.3	3.3	0.5	1.8	0.9	-1.3	0.3	1.6	0.6
Alzheimer’s Disease (in mother)	0.2	0.3	1.0	-0.1	-1.0	0.4	0.5	-0.5	0.0	0.4
Alzheimer’s Disease (in father)	1.1	1.2	3.5	1.5	-0.2	-0.7	-0.2	-1.9	-0.9	1.0
Alzheimer’s Disease (including proxy)	0.5	0.7	1.6	1.1	-0.5	-0.6	0.8	-1.3	-0.6	0.5
Crohns Disease (2017)	1.0	2.1	4.5	-0.9	1.5	1.7	-1.1	2.1	0.9	1.4
Irritable Bowel Disease (IBD)	0.6	1.4	2.7	-1.0	0.4	1.6	-1.2	1.1	1.3	1.3
Ulcerative Colitis (UC)	0.3	0.5	1.1	-0.9	-0.4	0.7	-0.9	-0.5	1.1	0.3
Major Depression (MDD)	0.5	0.6	1.6	0.9	0.7	0.8	0.2	0.7	1.3	0.3
Reaction Time	0.6	1.2	3.1	0.5	-1.0	1.0	1.8	1.7	0.2	0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.7	-0.8	-0.2	0.3	0.6	-0.4	0.0	-0.5
Breast Cancer	0.4	0.9	1.9	1.1	0.9	0.3	0.5	1.4	1.1	1.1
Ovarian Cancer	0.7	0.9	3.2	-0.9	-0.4	-0.5	-0.6	1.8	-1.1	-0.4
Prostate Cancer	0.4	0.5	2.3	0.6	0.3	-1.5	0.2	0.6	0.4	-0.5
Age at First Birth	0.3	0.5	1.5	-0.4	0.3	0.4	-1.2	-0.8	-0.9	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	1.2	-0.3	0.6	-0.3	-0.2	-0.1	-1.1	0.2
Coronary Artery Disease (CAD)	1.3	1.5	5.4	-0.6	0.2	0.0	-0.6	1.2	1.8	2.3
Crohns Disease (2012)	1.2	2.0	5.6	-0.3	2.1	0.4	-1.6	2.4	0.7	0.9
Mean Putamen Volume	0.9	1.0	3.8	2.0	0.7	-1.0	0.6	-0.6	0.5	-1.0
Fasting Glucose	0.4	0.4	1.7	-0.6	-0.0	0.5	-1.3	0.6	0.3	0.5
HbA1C	0.1	0.1	0.2	0.0	-0.5	0.3	-0.4	-0.3	0.3	-0.3
HDL Cholesterol	0.2	0.3	1.2	0.1	-0.4	0.2	1.1	-0.9	0.2	-0.3
LDL Cholesterol	0.6	1.0	2.8	0.4	1.1	-1.7	-1.0	-0.0	0.1	-1.4
Lupus	0.4	0.7	1.5	0.0	0.9	-1.2	-0.3	-0.6	-1.0	-1.0
Neuroticism (2016)	1.1	1.6	3.7	0.3	1.1	0.9	-0.8	1.9	1.0	1.9
Primary Biliary Cirrhosis	0.6	0.8	1.9	0.7	-1.3	1.4	0.7	0.8	0.5	0.6
Rheumatoid Arthritis	0.3	0.5	1.3	0.5	-1.1	1.0	0.6	0.5	-0.0	-0.5
Schizophrenia (2014)	0.6	1.4	3.9	2.0	-0.9	1.7	1.0	0.1	-0.4	1.0
Triglycerides	1.7	2.7	7.2	-0.1	1.9	1.9	0.5	2.7	1.2	1.8
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.5	0.1	-0.9	0.1	-1.2	0.3	0.5	0.2
Ulcerative Colitis	0.3	0.5	1.3	-0.4	0.5	0.9	-0.4	0.0	1.2	0.8
Blood Eosinophil Count	0.1	1.0	4.7	-0.7	0.1	-0.2	-2.2	0.8	1.1	0.4
Blood Platelet Count	0.2	2.6	12.1	-0.5	-0.2	1.5	-3.5	-1.1	-0.1	1.6
Blood Red Count	0.2	1.8	3.5	1.5	-1.9	0.9	1.8	0.5	-0.6	1.5
Blood White Count	0.2	1.3	5.1	-0.0	-2.2	1.2	-0.4	0.2	0.6	1.4
Heel T-Score	0.4	3.0	8.0	1.8	2.5	0.9	-0.1	-2.8	-0.7	1.4
BMI	0.3	2.0	5.5	0.2	1.7	2.3	-0.1	-0.3	1.0	2.1
Height	0.4	6.8	17.6	-4.2	-0.7	1.5	-2.9	4.1	1.4	0.4
Waist Hip Ratio (WHR)	0.8	3.5	7.6	2.0	-1.9	-1.9	1.5	0.5	-2.8	1.8
Systolic Blood Pressure	0.6	2.8	8.6	-2.9	1.6	0.2	-2.3	-0.7	-1.5	-0.6
Smoking Status	0.6	1.3	4.6	2.1	-1.1	1.1	0.8	-0.8	0.3	1.0
Allergy or Eczema	0.2	0.4	1.2	-0.4	-0.1	0.6	-1.1	0.7	0.7	0.3
Cardiovascular Disease	0.5	1.6	4.5	-0.9	0.8	1.6	-2.1	-1.1	1.1	0.4
Hypothyroidism (self reported)	0.7	1.6	6.2	-0.7	0.2	2.5	-0.5	0.2	0.1	2.0
Respiratory disease	0.5	1.2	2.4	-1.6	-0.5	-1.1	-1.4	0.2	-1.3	-0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.0	-0.1	-1.4	0.4	-0.7	-0.0	1.1	-0.1
Lung FEV1/FVC ratio	0.2	1.3	5.2	0.5	-0.0	-2.3	0.6	0.6	0.4	-1.6
Lung FVC	1.1	5.4	28.4	1.5	0.8	0.4	2.2	-5.3	-0.8	-1.2
Neuroticism	0.6	1.4	3.9	0.4	1.3	0.5	-0.6	1.8	0.1	2.0
Chronotype (morning person)	0.6	1.4	3.1	0.4	-1.4	0.3	1.2	-1.8	0.7	-1.6
Hair Pigment	0.0	0.5	1.1	0.3	1.1	1.1	-0.2	-0.9	-0.4	0.4
Tanning	0.2	2.8	6.5	1.7	-2.5	-1.8	1.6	-1.2	0.1	-1.8
Hand grip strength (left)	0.9	2.5	5.0	-1.4	1.7	0.0	-2.2	0.9	-1.3	2.2
Number of treatments/medications taken	0.6	1.2	3.0	-0.7	-0.2	1.6	-1.7	-1.0	0.9	0.5
Average weekly spirits intake	1.1	1.3	5.1	2.2	0.7	-0.6	1.2	0.8	0.8	0.6
Sensitivity / hurt feelings	0.5	0.9	1.7	-0.8	-0.1	-0.8	-1.1	0.9	-1.3	1.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.7	1.6	-0.5	-1.0	0.4	0.5	-0.7	0.1
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.5	-0.4	-0.5	0.8	-0.6	-0.3	-0.5
Relative age of first facial hair	2.2	4.5	12.9	-3.0	-0.5	0.9	-2.3	3.6	1.8	0.2
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	4.0	-0.6	-0.6	1.1	-2.0	-0.4	0.7	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.3	-0.4	-0.6	-0.3	-1.1	-0.7	-0.2	-0.4
Ever had hysterectomy (womb removed)	1.0	1.1	2.7	-0.3	-1.3	0.7	-1.1	1.2	-0.3	1.6
Systolic blood pressure, automated reading	0.9	2.7	6.4	-2.5	2.2	0.3	-2.0	-1.1	-1.4	0.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.7	0.6	-1.6	-0.1	0.3	-0.2	0.7	-1.4
Angina	0.4	0.5	1.6	-0.9	0.6	-0.5	-1.3	0.1	0.6	0.2
Medication for hormone replacement therapy	0.8	0.9	2.2	-1.1	1.3	1.5	-0.3	0.3	-0.3	0.9
Vitamin and mineral supplements	1.3	1.8	6.2	0.2	-0.8	-1.6	1.4	0.7	0.6	-2.5
Supplements: Zinc	1.2	1.3	2.4	1.3	1.2	1.4	1.3	0.1	-0.4	1.6
Medication: Co-codamol	1.2	1.4	3.5	-1.9	-1.1	1.7	-1.0	-0.4	-0.6	0.3
Medication: Metformin	0.3	0.4	1.2	-0.1	-1.1	1.0	-0.8	0.3	0.0	0.4
Diabetes (father)	1.0	1.3	2.5	-1.6	0.1	0.5	-1.5	0.4	-1.2	1.5
Diabetes (mother)	1.4	1.8	5.6	2.4	-2.0	-1.0	1.2	-0.4	0.4	-0.2
Severe depression (siblings)	0.8	0.9	3.2	1.4	0.4	-0.1	-0.2	-0.6	-0.7	1.8
Pack years adult smoking proportion	1.2	1.9	6.2	1.1	-1.9	-0.9	-0.1	2.5	1.2	0.0
Impedance of leg (right)	1.3	6.3	38.0	-0.2	-1.7	-1.7	-0.2	6.2	-0.3	0.5
Leg fat-free mass (left)	0.6	3.1	9.3	-1.5	1.0	3.0	-1.2	0.0	2.4	1.4
Trunk fat percentage	1.9	7.6	24.6	-2.4	1.2	1.9	-2.3	5.0	2.3	2.6
Hand grip strength (right)	0.9	2.4	6.8	-1.3	1.9	-1.2	-1.6	-0.4	-2.6	0.6
Townsend deprivation index at recruitment	0.3	0.4	1.3	-0.4	-0.2	-0.3	0.5	-0.8	-1.1	0.0
Current tobacco smoking	0.7	1.2	3.0	1.7	0.0	-0.7	1.6	1.1	-0.9	0.4
Average weekly fortified wine intake	0.7	0.8	2.6	1.6	1.3	-0.1	0.1	-0.7	0.2	0.8
Maternal smoking around birth	0.5	0.7	2.0	-0.2	1.0	0.1	-0.6	1.2	-0.2	1.4
Fed-up feelings	0.5	0.9	3.6	0.3	-0.9	-1.9	-0.9	0.3	-0.9	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.4	0.8	0.3	0.6	0.2	0.6	-0.0	1.2
Relative age voice broke	1.4	2.2	6.5	-2.2	0.7	-0.1	-1.8	2.5	0.2	0.4
Taking other prescription medications	0.8	1.2	2.7	-0.4	-0.8	1.6	-1.5	-0.1	1.6	0.7
Age when periods started (menarche)	8.0	19.1	99.4	-2.0	-1.1	2.1	1.1	10.0	4.5	1.8
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.6	-0.5	-0.2	0.1	-1.6	-0.4	-0.4	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	5.5	1.8	0.7	0.3	0.8	-2.3	-1.0	1.0
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	5.2	0.3	1.9	-0.7	2.3	-0.1	-0.9	0.8
Qualifications: CSEs or equivalent	0.6	0.8	1.9	-0.6	1.4	-1.2	0.1	1.4	-0.5	-0.1
Serious illness, injury or assault to yourself	1.2	1.5	4.5	-1.5	2.1	-0.1	-1.3	-0.9	-1.2	-0.1
High blood pressure	1.5	4.3	13.6	-3.2	1.4	1.5	-3.7	-1.4	0.3	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.5	0.4	-0.4	0.4	-0.3	1.2	0.9	0.3
Multivitamins +/- minerals	1.1	1.4	2.8	-1.5	0.9	0.3	-1.3	0.0	-1.7	1.6
Stomach or abdominal pain in last month	0.6	0.8	1.9	-1.1	1.4	0.4	-1.2	-0.1	-0.9	0.2
Supplements: Glucosamine	1.8	2.3	8.1	-1.0	-0.2	-0.2	-2.2	-2.8	-1.4	0.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.6	-0.8	-1.2	-0.8	-1.3	-1.2	1.0	-1.6
Medication: Atenolol	0.8	1.0	2.2	-0.3	-0.2	-1.1	-0.9	-0.9	1.3	-1.5
Medication: Levothyroxine sodium	0.3	0.4	1.3	-0.4	0.4	1.1	0.1	0.8	0.4	0.8
Sitting height	0.3	2.0	4.0	-1.3	-1.5	1.4	-1.4	2.0	1.4	0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	0.3	-0.4	0.3	-0.3	0.1	0.8	0.4
High blood pressure (mother)	3.8	5.4	8.6	-2.2	1.5	-2.2	-2.7	-2.6	-2.9	-1.7
Body mass index (BMI)	0.7	2.8	6.3	-0.4	2.2	2.5	-0.7	-0.8	1.0	2.4
Impedance of leg (left)	1.0	4.7	26.0	-0.3	-1.3	-1.9	-0.7	5.1	-1.1	0.5
Leg predicted mass (left)	0.6	3.2	9.7	-1.5	1.0	3.1	-1.2	0.1	2.4	1.5
Trunk fat mass	1.4	6.0	15.5	-2.0	1.2	2.1	-2.1	3.9	2.5	2.5
Waist circumference	0.5	2.0	6.1	-0.3	1.5	1.8	-0.6	0.7	1.1	2.5
Number of incorrect matches in round	1.5	2.5	12.5	0.1	3.5	0.0	-0.1	0.5	-1.3	1.8
Past tobacco smoking	0.8	1.5	9.2	-0.8	-0.7	-0.3	0.0	3.0	0.1	-0.2
Alcohol usually taken with meals	1.0	1.6	5.0	1.3	0.1	-0.8	0.9	-1.7	0.0	-2.2
Nervous feelings	0.9	1.7	4.5	-0.8	1.0	1.6	-1.1	1.2	0.9	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	4.3	0.3	-0.2	1.3	-0.3	-0.6	-1.1	2.1
Hearing difficulty/problems with background noise	0.2	0.3	0.9	-0.0	-1.0	-0.4	-0.8	0.3	-0.1	-0.1
Hair/balding pattern: Pattern 2	0.7	0.8	2.4	1.1	0.6	-0.5	1.5	-0.6	-1.1	0.1
Had menopause	0.5	0.7	1.9	0.9	-1.1	0.0	0.2	-1.4	-0.7	-0.3
Had other major operations	1.4	1.7	4.4	0.9	-1.0	-0.7	1.6	-2.1	-1.3	-1.1
Forced vital capacity (FVC)	0.2	0.7	2.1	-0.3	0.6	0.6	0.7	-1.4	0.8	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	6.4	1.2	1.6	0.2	0.6	-2.5	-1.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	2.1	1.1	-0.3	-1.4	0.8	0.8	0.7	-1.5
Qualifications: None of the above	2.2	4.7	11.2	-1.9	-2.0	1.9	-1.0	3.3	1.2	2.8
Financial difficulties in last 2 years	0.4	0.6	2.6	1.6	0.6	-0.4	0.7	0.5	-0.3	-0.5
Mouth/teeth dental problems	1.7	2.7	8.5	1.9	-0.3	-2.9	1.0	0.3	-0.8	-2.2
Heart attack	0.4	0.5	1.1	-0.4	-0.8	-0.7	-0.2	0.5	1.0	-1.0
Allergy	0.3	0.6	1.3	0.8	1.1	0.2	1.0	-1.1	0.4	0.1
Pain all over the body in last month	1.6	1.7	5.6	0.2	-1.2	2.4	0.5	-0.1	1.1	1.9
Diabetes (self-reported)	0.6	0.9	2.7	0.7	-1.1	-1.0	-0.6	-0.7	0.5	-1.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.9	-0.5	-0.5	0.8	1.3	1.7	-0.1	0.1
Medication: Ramipril	2.2	2.8	8.4	0.8	-1.2	1.9	0.2	2.9	2.1	0.8
Medication: Simvastatin	0.7	1.1	2.2	1.0	0.0	1.3	0.5	-0.9	1.2	1.5
Fluid intelligence score	0.2	0.5	1.5	-1.0	1.2	-0.0	0.7	-0.2	0.3	-0.6
Illnesses of siblings	1.2	1.7	4.7	0.5	2.2	-0.8	1.4	1.2	-1.3	-1.0
Neuroticism score	0.7	1.5	5.9	-0.2	0.9	0.1	-1.3	1.0	-1.0	2.4
Weight	0.8	3.9	8.3	-1.4	1.4	2.9	-1.8	1.1	2.0	2.5
Impedance of arm (right)	2.0	9.2	56.1	-1.5	-0.8	-1.3	-0.4	7.5	1.9	-0.7
Arm fat percentage (right)	1.1	4.2	7.4	-1.1	2.1	2.0	-1.1	2.7	2.3	2.4
Trunk fat-free mass	0.4	2.2	6.9	-0.4	0.8	2.6	-0.6	-1.9	1.2	1.4
Hip circumference	1.1	4.7	12.7	-0.8	1.0	3.5	-0.7	1.9	3.6	1.6
Time employed in main current job	0.9	1.1	3.4	-0.3	0.7	-1.4	0.7	-0.9	-0.6	-1.9
Alcohol intake versus 10 years previously	1.1	1.6	6.7	0.8	-2.6	0.7	0.6	1.1	0.9	1.0
Father’s age at death	1.1	1.5	3.6	1.1	-0.3	-1.9	-0.9	-1.4	-1.1	-1.4
Worrier / anxious feelings	1.0	1.9	6.0	1.1	2.5	-0.5	-0.9	-2.1	-0.6	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.2	0.7	0.4	0.2	0.6	0.2	0.6	-0.9	0.2
Falls in the last year	0.1	0.2	0.5	0.6	-0.7	0.4	0.2	-0.4	0.0	-0.0
Hair/balding pattern: Pattern 3	1.0	1.5	5.9	-0.3	-0.5	1.9	-0.9	0.0	0.3	2.4
Number of live births	0.4	0.5	1.3	0.8	0.1	1.1	-0.1	0.6	0.0	1.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.2	0.2	1.3	0.6	1.5	-0.8	0.9	-0.3
Pulse rate	1.2	2.0	5.9	-0.9	1.7	2.4	0.3	0.4	0.4	2.0
Happiness	0.1	0.1	0.2	0.5	0.4	0.1	-0.4	0.4	-0.1	0.2
Noisy workplace	1.1	1.4	4.8	1.3	-0.3	-0.4	1.3	-2.2	-0.9	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.2	0.5	1.5	0.5	0.9	-0.6	0.8	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.2	-0.7	0.6	0.3	-1.0	-1.8	-1.1	0.9
Mouth/teeth dental problems: Dentures	0.3	0.5	1.2	-0.3	-1.1	0.9	-0.2	-0.5	0.7	0.7
Asthma	0.9	1.8	4.4	-1.7	-0.8	-1.4	-2.1	0.8	-1.3	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	-0.4	0.3	0.3	0.4	0.4	-0.3	0.1
Medication: Cholesterol lowering	0.3	0.5	1.2	0.6	0.9	0.3	0.5	0.4	1.1	0.5
Depression (self-reported)	0.5	0.6	2.7	0.2	1.6	0.8	-0.7	-0.5	-0.3	0.4
Medication: Lansoprazole	1.2	1.4	4.4	0.6	-0.0	1.8	-1.2	-0.5	0.4	2.1
Prospective memory result	1.3	1.6	3.3	1.7	-1.8	0.1	-0.3	-1.7	-1.3	0.6
Lung cancer (father)	0.2	0.2	0.6	-0.3	-0.8	0.4	0.7	-0.0	-0.2	0.1
Illnesses of mother	3.4	4.2	10.6	-0.3	0.7	3.3	1.2	2.6	1.7	2.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.7	-0.0	1.5	1.3	1.6	-0.2	0.9	0.5
Pulse wave Arterial Stiffness index	1.2	1.4	3.9	-2.0	0.9	-0.1	-1.9	0.8	-0.1	-0.9
Impedance of arm (left)	2.2	10.0	58.8	-2.1	-1.1	-1.0	-0.7	7.7	2.0	-0.7
Arm fat mass (right)	1.1	4.4	7.6	-1.1	1.9	2.7	-1.3	2.1	2.2	2.8
Trunk predicted mass	0.4	2.1	6.7	-0.4	0.7	2.6	-0.6	-1.8	1.2	1.4
Standing height	0.5	4.7	14.0	-2.3	-1.6	0.8	-2.5	3.7	2.1	0.1
Length of working week for main job	0.6	0.7	2.9	-1.7	-0.4	0.3	-1.1	0.3	0.4	-0.4
Exposure to tobacco smoke at home	0.5	0.5	1.3	1.1	-0.8	-0.9	0.8	-0.0	-0.3	-0.4
Breastfed as a baby	3.6	4.4	16.2	-0.7	0.3	-1.5	-0.8	-4.0	-2.8	-1.9
Tense / ‘highly strung’	1.0	1.7	4.3	-0.5	2.0	1.1	-0.9	-0.7	-0.9	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	4.7	2.2	-0.4	-1.7	0.5	-1.3	0.9	-1.8
Hair/balding pattern: Pattern 4	0.3	0.8	4.2	0.3	-0.2	0.5	-0.2	-2.1	0.4	-1.0
Birth weight of first child	1.4	2.5	10.3	1.9	0.6	1.0	1.6	0.0	3.2	0.1
Peak expiratory flow (PEF)	0.3	0.7	3.9	0.2	2.0	0.1	0.7	-0.1	0.3	0.0
Pulse wave reflection index	1.7	2.1	5.5	-2.2	1.1	-1.2	-1.3	-0.1	-0.7	-2.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	0.5	0.0	0.6	-0.7	-0.8	-0.8	1.1
Loud music exposure frequency	0.6	0.7	2.1	1.4	0.6	-0.4	1.1	0.2	-0.8	0.3
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	6.2	2.0	-0.4	-0.8	1.4	-2.5	-0.5	-1.2
Mouth/teeth dental problems: Bleeding gums	3.2	4.1	9.1	-2.2	0.7	3.0	-0.2	2.6	1.5	2.4
Blood clot in the leg (DVT)	1.3	1.7	7.5	-2.7	-0.7	0.4	-1.5	1.0	0.6	-0.5
Medication: Paracetamol	0.6	1.1	2.6	-1.6	1.6	1.2	-0.3	0.1	0.2	0.8
Headache pain in last month	1.2	2.1	4.9	-0.7	1.0	1.4	-1.0	2.2	0.5	2.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.5	-0.1	-0.9	-0.2	-0.3	0.1	-1.9	0.4
Glaucoma (self-reported)	0.9	1.1	2.5	0.9	-0.7	-0.6	1.3	-1.2	-1.6	-0.1
Gout (self-reported)	0.1	0.2	1.0	-0.3	0.3	-1.0	-0.3	0.1	-0.2	-0.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	5.7	0.0	0.3	2.4	-0.6	0.2	0.9	2.2
Medication: Amlodipine	1.9	2.7	6.3	-2.5	1.1	0.4	-2.0	-2.1	-1.6	0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.1	-0.3	-0.1	-1.0	-0.5	0.3	0.3	-0.8
Birth weight	0.4	0.8	3.7	1.9	0.1	-0.0	1.0	0.2	1.0	0.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.7	-0.7	0.4	-0.5	-1.3	0.1	0.2	-0.3
High blood pressure (siblings)	0.8	1.1	2.8	-1.6	-0.4	0.0	-1.7	-1.5	0.1	0.5
Forced vital capacity (FVC), Best measure	0.2	0.7	1.4	-0.6	0.8	1.2	0.9	-1.1	0.7	-0.1
Body fat percentage	1.5	5.9	16.9	-1.7	1.4	2.0	-1.8	4.1	2.1	2.9
Leg fat percentage (right)	0.7	2.7	7.7	-0.2	1.0	1.4	-0.8	2.6	1.0	2.8
Arm fat-free mass (right)	0.5	2.4	7.8	-0.7	0.7	2.8	-1.1	-1.7	0.9	1.9
Exposure to tobacco smoke outside home	0.5	0.6	1.5	0.2	0.3	1.2	0.0	-1.0	-0.3	1.2
Comparative body size at age 10	1.3	3.7	12.9	2.6	1.2	0.5	1.6	-3.6	-0.5	1.2
Number of full brothers	1.0	1.3	3.5	0.7	0.2	1.7	1.2	-0.3	-1.0	1.9
Worry too long after embarrassment	1.5	2.5	6.4	-0.3	0.7	1.4	-1.5	2.5	0.3	2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	0.3	1.0	1.1	0.4	0.4	0.4	0.1
Wheeze or whistling in the chest in last year	1.1	1.9	5.1	-1.9	0.0	-1.0	-2.3	1.1	-1.5	0.5
Number of children fathered	1.8	2.0	6.3	1.5	-1.7	-2.5	0.4	0.1	0.1	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	4.0	-0.2	2.0	-0.1	-0.7	-0.0	-1.5	0.6
Age at first live birth	1.4	2.5	12.1	0.4	-0.9	-1.6	0.4	-1.2	0.7	-3.5
Pulse wave peak to peak time	1.0	1.1	3.0	1.7	-0.9	0.2	1.6	-0.6	0.1	1.1
Health satisfaction	0.6	0.7	2.0	-0.5	1.1	1.4	-0.2	0.5	0.6	1.0
Shortness of breath walking on level ground	0.4	0.5	1.3	-0.3	-0.9	0.8	-0.5	-1.1	0.1	0.4
Qualifications: College or University degree	0.7	2.1	7.9	2.1	0.4	1.1	2.8	-0.8	0.1	0.5
Eye problems/disorders: None of the above	1.9	2.2	8.9	-0.5	0.0	3.0	0.2	1.3	0.8	1.9
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.0	-0.4	-0.1	-1.0	0.2	-0.9	-0.3	-0.1
Emphysema/chronic bronchitis	0.2	0.2	0.4	-0.2	0.5	0.1	-0.7	0.2	-0.7	0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	1.6	0.4	-0.7	-1.2	0.4	0.3	-0.8	-0.8
Neck or shoulder pain in last month	0.5	0.7	2.8	-0.6	0.0	-0.9	-1.1	-0.1	-1.7	-0.2
Medication: Blood pressure	0.4	0.7	3.1	-1.0	-0.3	0.6	-0.5	0.1	1.8	-0.5
Angina (self-reported)	0.4	0.5	1.6	-1.0	0.2	-0.2	-1.3	0.3	0.6	0.5
Migraine (self-reported)	0.3	0.4	1.9	0.4	-1.4	-0.2	0.8	0.4	-0.0	-0.3
Medication: Ibuprofen	0.3	0.4	1.0	0.4	0.1	-0.6	0.9	0.3	0.3	-1.0
Medication: Allopurinol	0.5	0.6	1.5	-1.1	0.7	-0.9	-0.4	-0.1	-0.5	-1.2
Medication: Omeprazole	0.4	0.4	2.4	0.2	-0.3	0.4	-0.6	-1.5	-0.1	0.3
Medication: Seretide 50 evohaler	0.2	0.3	0.7	-0.8	0.1	-0.7	-0.5	0.5	-0.5	0.1
Mean time to correctly identify matches	0.6	1.2	3.9	1.2	-2.0	-0.4	1.5	0.4	-0.1	-0.6
Heart disease (mother)	0.6	0.8	3.0	1.7	0.2	-0.8	0.8	-0.8	0.4	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	0.6	-0.4	-1.2	0.2	1.1	-0.3	0.0
Whole body fat mass	1.3	5.4	9.9	-1.6	1.5	2.4	-1.8	3.1	2.2	2.9
Leg fat mass (right)	1.0	4.0	9.3	-0.6	1.5	2.6	-1.0	2.3	1.8	3.1
Arm predicted mass (right)	0.5	2.7	8.2	-0.7	0.9	2.9	-1.2	-1.7	0.6	2.1
Pulse rate, automated reading	1.0	3.1	16.1	-0.4	4.0	1.4	-0.1	-0.3	-0.8	1.8
Alcohol intake frequency.	0.6	1.3	3.0	-1.1	-0.1	1.3	-1.7	0.5	0.8	1.5
Comparative height size at age 10	0.3	1.6	5.0	-0.1	-1.5	-1.0	-1.6	-2.2	-0.8	-0.5
Number of full sisters	1.0	1.2	2.5	1.6	-0.7	0.2	1.2	1.4	0.7	1.1
Suffer from ‘nerves’	1.9	3.0	10.5	-0.2	0.9	2.1	-1.4	1.4	1.3	3.2
Overall health rating	0.3	0.6	1.7	-0.9	0.4	0.8	-1.3	0.9	0.3	0.1
Chest pain or discomfort	1.0	1.4	5.0	0.4	0.9	-1.8	0.8	2.2	-0.3	-0.3
Had major operations	1.3	1.6	5.6	0.1	0.9	-0.3	-0.6	-2.4	-1.9	-0.7
Age at last live birth	1.3	1.9	8.8	0.8	-0.6	-1.6	0.1	-1.0	0.3	-3.0
Family relationship satisfaction	2.7	3.3	6.8	1.4	1.1	2.2	1.0	2.1	1.6	2.6
Leg pain on walking	0.9	1.2	4.9	-0.1	-0.2	2.2	0.6	0.0	0.0	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	5.4	-1.3	2.3	-0.5	-1.0	-0.9	-0.6	-0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.9	1.2	-0.6	0.3	1.4	0.2	-0.2	0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	-1.0	-0.2	0.4	-0.4	-0.2	0.6	-0.3
Medication: Aspirin	0.7	0.9	3.7	0.5	-1.0	0.9	-0.6	-0.3	1.9	-0.1
Supplements: Vitamin C	0.2	0.3	1.0	0.6	0.3	0.4	-0.6	0.2	-0.2	1.0
Knee pain experienced in last month	1.5	2.4	5.2	-2.2	-0.8	-1.7	-2.3	0.1	-1.5	-0.8
Hypertension (Self-reported)	1.2	3.4	11.9	-2.5	1.1	1.4	-3.4	-1.5	0.5	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.7	-0.0	0.6	0.7	-0.7	-1.1	-0.4	1.3
Illnesses of father: Heart disease	0.1	0.2	0.6	0.6	-0.5	-0.3	0.8	-0.0	0.4	0.0
Illnesses of siblings: Diabetes	0.5	0.7	2.0	0.1	-1.1	0.6	-0.8	-0.7	0.1	1.4
Smoking status: Previous	1.0	1.5	7.8	0.7	0.4	0.8	-0.5	-2.8	0.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.8	-1.7	1.3	1.6	-0.5	1.2	1.5	0.9
Whole body fat-free mass	0.5	2.8	9.2	-1.0	1.0	3.0	-1.0	-1.3	1.6	1.7
Leg fat-free mass (right)	0.5	2.8	8.5	-1.4	1.1	2.9	-1.2	-0.8	2.1	1.2
Arm fat percentage (left)	1.1	4.3	7.3	-1.4	2.0	2.2	-1.2	2.7	2.2	2.4
Average weekly red wine intake	0.3	0.5	2.1	-0.3	-0.1	-0.9	-0.0	-0.5	-0.4	-1.4
Handedness (chirality/laterality): Left-handed	2.2	2.6	9.6	0.4	0.3	2.4	-1.1	0.4	1.2	3.1
Mood swings	0.4	0.8	2.6	1.6	0.1	-1.1	0.7	0.4	-0.8	0.7
Loneliness, isolation	0.4	0.5	1.1	1.0	-0.4	0.5	0.9	0.3	-0.5	1.0
Long-standing illness, disability or infirmity	0.6	0.8	3.1	-0.2	-1.8	0.2	-0.7	-0.8	1.0	-0.8
Ever had bowel cancer screening	2.3	2.7	8.3	-0.9	-0.3	-1.8	-2.9	-1.4	0.4	-2.0
Diabetes diagnosed by doctor	0.4	0.6	2.1	1.0	-1.4	0.0	-0.1	0.1	0.9	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.2	-0.8	1.5	-0.4	-0.6	-0.6	-0.9	-0.5
Friendships satisfaction	0.9	1.1	3.0	0.3	0.9	1.7	0.1	1.1	1.0	1.3
Qualifications: nursing, teaching	1.5	2.3	5.1	2.1	0.7	-0.4	1.6	-2.3	0.6	-1.8
Commuting to job workplace: Walk	1.3	1.4	3.8	-0.8	2.0	-0.0	-0.8	-1.4	-1.7	0.3
Eye problems/disorders: Cataract	1.0	1.1	2.7	-0.7	0.7	-1.6	-0.8	-1.0	-0.7	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	5.0	-1.6	1.6	2.2	-0.8	-1.3	-0.9	1.4
Medication for cholesterol	0.9	1.4	2.8	1.0	-1.4	-1.4	1.7	0.9	0.7	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	-0.4	-0.9	-0.6	0.2	0.6	0.1	-0.6
Back pain experienced in last month	1.8	2.6	8.4	-1.5	-0.6	-1.1	-1.7	-1.7	-2.9	-0.1
Mineral and other dietary supplements	0.9	1.2	3.1	0.6	-0.4	1.1	1.2	1.8	0.7	1.2
Breast cancer (self-reported)	1.9	2.3	4.1	1.7	-1.9	-1.7	1.4	-0.4	0.3	-2.0
Asthma (self-reported)	0.9	1.7	3.9	-1.7	-0.6	-1.4	-2.0	0.7	-1.4	-0.6
Osteoporosis (self-reported)	0.7	0.8	3.2	-1.2	0.4	1.8	0.1	-0.4	-0.7	0.7
Osteoarthritis (self-reported)	1.4	1.8	7.8	-0.9	0.5	0.1	-1.7	-2.8	-0.8	-0.1
Medication: Aspirin	0.8	1.0	3.8	0.8	-1.3	0.8	-0.5	-0.5	2.0	-0.2
Medication: Gliclazide	1.6	1.8	4.3	1.6	-2.1	-0.8	0.1	0.2	1.1	-2.0
Illnesses of father: None of the above (group 1)	0.8	1.0	2.2	0.4	-0.5	0.7	1.1	1.5	1.3	-0.9
Smoking status: Current	0.7	1.1	3.1	1.5	0.2	-0.5	1.8	0.8	-1.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.4	0.6	1.6	0.6	1.4	-1.5	0.7	-0.3
Whole body water mass	0.5	2.9	9.4	-0.9	1.1	3.1	-1.0	-1.5	1.5	1.8
Leg predicted mass (right)	0.5	2.9	8.9	-1.4	1.2	3.0	-1.2	-0.7	2.1	1.3
Arm fat mass (left)	0.9	3.7	5.7	-1.3	1.8	2.4	-1.4	1.8	2.0	2.4
Number of self-reported non-cancer illnesses	1.3	2.3	10.3	-1.3	-0.8	1.1	-3.2	-1.4	0.2	0.7
Average weekly champagne plus white wine intake	0.7	1.0	3.2	-0.3	1.1	-0.2	0.7	-1.8	-0.8	-1.1
Miserableness	1.7	3.0	10.6	-0.8	-0.2	1.9	-0.4	2.4	0.1	3.3
Guilty feelings	0.5	0.8	2.2	1.4	-0.1	-0.3	-0.0	1.5	0.7	0.9
Wears glasses or contact lenses	1.4	1.6	7.9	0.7	-0.5	-1.2	-0.4	-2.8	-0.8	-0.8
Ever taken oral contraceptive pill	0.9	1.0	3.7	-1.1	-0.4	0.2	-0.2	1.9	0.7	1.2
Hearing aid user	0.1	0.1	0.4	-0.2	0.5	-0.6	0.1	-0.4	0.1	-0.1
Mother’s age at death	0.4	0.5	2.3	-0.5	1.5	-0.2	0.5	0.4	-0.8	0.2
Financial situation satisfaction	0.3	0.3	1.1	0.3	1.1	-0.2	-0.5	-0.5	-0.7	-0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	-0.1	1.0	1.0	-0.7	-1.1	-0.2	0.7
Commuting to job workplace: Public transport	0.5	0.6	1.2	0.8	-0.2	-0.5	0.9	0.8	1.1	-0.7
Eye problems/disorders: Glaucoma	1.4	1.6	4.6	2.1	-0.2	-1.4	1.5	-1.2	-0.9	-0.4
Medication: Blood pressure	1.5	2.8	9.8	-1.6	1.7	0.9	-3.1	-1.8	-0.2	0.2
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.2	-0.6	1.5	0.3	-0.1	-0.8	-1.2	-0.1
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.1	-1.2	1.8	-0.8	-1.7	-1.0	-0.1	-0.8
High cholesterol (Self-reported)	0.6	1.0	2.8	1.7	0.0	0.5	1.6	-1.3	-0.3	0.3
Medication: Bendroflumethiazide	0.6	1.0	2.0	-1.1	-0.8	0.8	-1.4	0.7	1.2	0.3
Medication: Paracetamol	0.2	0.3	1.0	-0.1	1.0	0.4	0.2	-0.3	0.8	-0.1
Medication: Lisinopril	0.8	1.0	5.1	-0.2	1.0	0.1	0.6	-2.2	0.5	-0.7
Medication: Atorvastatin	1.6	2.0	4.9	1.7	-0.9	-2.2	0.4	-0.9	-0.3	-2.0
Illnesses of father: High blood pressure	0.5	0.6	2.4	0.7	0.4	0.2	1.5	-0.0	-0.8	0.8
Alcohol drinker status: Never	0.7	0.8	1.7	-0.9	-0.3	-0.8	-1.0	-1.3	-0.1	-1.2
Ever smoked	0.9	1.6	7.3	1.5	1.1	0.3	0.5	-2.7	-0.0	0.2
Basal metabolic rate	0.6	3.1	9.7	-1.1	1.0	3.1	-1.2	-0.5	1.9	2.0
Leg fat percentage (left)	0.6	2.1	6.6	-0.4	1.5	1.3	-1.1	1.5	0.5	2.6
Arm fat-free mass (left)	0.4	2.3	6.6	-0.4	1.0	2.6	-1.0	-1.4	1.1	2.0
Number of operations (self-reported)	0.4	0.6	2.0	0.1	-1.3	0.8	-0.4	-1.4	0.2	0.1
Average weekly beer plus cider intake	0.5	0.7	2.3	-0.4	-0.8	1.0	-0.2	1.0	0.4	1.5
Irritability	0.2	0.4	1.6	0.7	0.3	0.5	-0.2	-0.2	-0.2	1.3
Risk taking	0.8	1.2	2.9	0.8	0.2	-1.7	-0.6	-1.2	-1.4	-0.9
Ever had prostate specific antigen (PSA) test	2.4	2.7	7.3	0.9	-2.7	-2.0	-0.3	1.3	0.6	-2.2
Fractured/broken bones in last 5 years	0.7	0.9	2.5	-0.6	-1.1	-0.6	-0.1	-1.3	-1.6	-0.6
Age started oral contraceptive pill	0.7	0.9	3.4	-1.8	0.1	1.4	-0.7	0.0	-0.4	0.4
Diastolic blood pressure, automated reading	1.3	4.0	10.3	-3.2	2.5	2.6	-2.0	-0.2	0.2	0.9
Ever depressed for a whole week	1.7	2.1	6.9	2.6	-0.2	-1.8	1.5	0.7	0.0	-1.3
Unable to work because of sickness or disability	0.3	0.4	1.2	-0.6	0.6	0.0	0.6	0.5	-1.1	0.7
Commuting to job workplace: Cycle	0.2	0.2	0.7	0.1	-0.2	0.9	-0.7	-0.4	0.2	-0.3
Myopia	0.5	0.8	3.1	-1.3	0.1	0.4	0.5	1.8	-0.2	0.5
Vascular/heart problems diagnosed by doctor	1.4	3.8	12.6	2.7	-1.1	-1.2	3.6	1.8	-0.4	-0.3
Cholesterol lowering medication	1.0	1.5	4.0	2.0	-1.5	-0.4	0.7	-1.8	-0.6	0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.1	1.0	0.2	0.9	-0.5	-1.8	-0.7	0.7
Pain experienced in last month	1.0	1.7	4.4	1.8	-0.7	-0.5	2.1	0.7	1.2	-1.3
Supplements: Calcium	0.2	0.2	0.5	0.6	-0.7	0.1	0.6	0.2	0.1	-0.0
Basal cell carcinoma (self-reported)	0.6	0.8	1.6	0.8	-0.9	-1.3	0.8	-0.2	-0.9	-0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	-0.4	-0.6	-0.7	-0.3	0.4	0.8	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	6.9	-2.6	-0.7	0.0	-1.3	1.0	0.6	-0.8
Heart disease (siblings)	1.0	1.2	4.5	0.2	-2.1	0.9	-0.9	-1.0	1.0	0.4
Alcohol drinker status: Previous	0.5	0.5	1.9	0.9	-0.3	0.1	-0.8	-1.4	0.0	0.2
Pack years of smoking	1.1	1.6	4.7	0.8	-1.9	-1.0	-0.5	2.2	1.1	-0.1
Impedance of whole body	1.8	9.2	56.0	-1.5	-1.4	-1.7	-0.8	7.5	0.8	-0.4
Leg fat mass (left)	0.9	3.5	8.5	-0.7	1.7	2.5	-1.2	1.7	1.4	2.9
Arm predicted mass (left)	0.5	2.5	7.2	-0.7	1.0	2.7	-1.3	-1.5	0.8	2.1