TWAS hub - OSBPL3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.056	0.0250	1.9e-02	0.015	0.003	0.016	0.004	0.027	4.9e-03	1.2e-01	3.6e-03	8.4e-02	3.0e-04
2	METSIM	Adipose	0.116	0.0284	4.0e-10	0.053	0.067	0.077	0.068	0.078	1.8e-08	3.2e-10	1.4e-11	1.8e-10	8.4e-12
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.137	0.0510	3.3e-04	0.111	0.068	0.087	NA	0.097	6.7e-07	1.0e-04	1.1e-05	NA	3.6e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Omeprazole	4.6	5.5	8.2	-1.2	-2.6	-2.9
Leg fat percentage (left)	4.1	15.0	27.7	-5.3	-1.6	-3.8
Leg fat percentage (right)	3.8	13.7	23.5	-4.8	-1.6	-3.9
Alcohol usually taken with meals	3.6	5.8	12.2	3.5	2.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	3.6	4.1	5.4	1.8	1.9	2.3
Body fat percentage	3.5	13.7	25.4	-5.0	-0.6	-3.9
Medication: Omeprazole (e.g. Zanprol)	3.4	4.1	6.5	-0.7	-2.5	-2.3
Trunk fat percentage	3.3	13.0	26.2	-5.1	-0.3	-3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.3	3.9	6.2	-2.5	-1.4	-1.8
Qualifications: O levels/GCSEs or equivalent	3.2	5.2	9.2	3.0	2.3	1.1
Medication: Allopurinol	3.0	4.0	11.3	-3.4	-0.8	-0.3
Leg fat mass (left)	3.0	11.6	21.7	-4.7	-1.4	-3.4
Arm fat percentage (right)	2.9	11.3	19.5	-4.4	-0.9	-3.7
Trunk fat mass	2.8	11.9	24.2	-4.9	-0.7	-3.3
Financial difficulties in last 2 years	2.8	3.7	6.4	-0.8	-2.0	-2.5
Leg fat mass (right)	2.8	10.8	20.0	-4.5	-1.2	-3.3
Coronary Artery Disease (CAD)	2.7	3.3	9.5	3.1	-0.3	-0.5
Vitamin and mineral supplements	2.7	3.7	5.5	-1.7	-1.6	-2.4
Medication: Atenolol	2.7	3.4	6.6	-1.5	-1.2	-2.6
Waist circumference	2.7	9.9	15.4	-3.9	-1.8	-3.3
Birth weight of first child	2.7	4.9	6.5	2.5	-2.5	-1.4
Whole body fat mass	2.7	11.4	21.9	-4.7	-0.9	-3.4
Arm fat percentage (left)	2.7	10.9	20.1	-4.5	-0.3	-3.6
Major Depression (MDD)	2.6	3.2	9.1	-0.7	0.1	-3.0
Hearing aid user	2.6	2.9	6.3	-2.5	-1.1	1.1
Tinnitus: Yes, now most or all of the time	2.6	3.0	8.6	0.6	0.5	2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.3	6.8	-2.6	-0.9	-1.5
Multivitamins +/- minerals	2.4	3.0	4.6	1.9	0.9	2.1
Arm fat mass (right)	2.3	9.4	18.1	-4.3	-0.8	-3.1
Eye problems/disorders: Cataract	2.3	2.6	6.7	-2.6	-0.1	-1.1
Neuroticism (2016)	2.2	3.2	5.8	-0.2	-1.9	-2.4
Hearing difficulty/problems: Yes	2.2	3.4	8.3	-0.7	-2.9	1.2
Qualifications: None of the above	2.2	4.7	6.2	-2.1	-2.5	-1.8
Arm fat mass (left)	2.1	8.6	16.4	-4.1	-0.4	-3.0
Hearing difficulty/problems with background noise	2.0	3.2	8.8	0.0	-1.0	3.0
Body mass index (BMI)	1.9	8.1	14.8	-3.9	-0.9	-2.9
Qualifications: nursing, teaching	1.9	2.9	5.2	1.9	2.3	0.2
Ever taken oral contraceptive pill	1.9	2.2	5.5	0.3	-0.9	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.0	5.6	2.4	-0.7	0.1
Loneliness, isolation	1.8	2.4	2.9	-1.6	-1.7	-1.3
Medication: Bendroflumethiazide	1.8	2.8	5.8	-2.4	-1.6	0.2
Commuting to job workplace: Public transport	1.7	2.0	3.8	-0.1	2.0	1.5
Pack years of smoking	1.7	2.5	4.7	-0.3	-2.2	-1.6
Time employed in main current job	1.6	1.9	3.7	0.6	1.3	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	6.0	0.7	-0.8	-2.5
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	4.2	1.9	2.1	1.5
Type 2 Diabetes (T2D) (2018)	1.5	2.8	8.2	-2.9	-0.5	-0.0
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.3	1.8	0.9	1.0
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	5.1	0.7	2.3	1.8
Heart disease (mother)	1.5	1.8	2.6	-1.6	-1.3	-1.0
Supplements: Fish oil (including cod liver oil)	1.5	2.0	2.9	1.5	0.9	1.7
Pack years adult smoking proportion	1.4	2.1	3.5	-0.3	-1.9	-1.6
Taking other prescription medications	1.4	2.1	2.9	-1.3	-1.3	-1.7
High blood pressure (mother)	1.4	1.9	4.5	0.5	-2.1	-1.0
Pain all over the body in last month	1.4	1.5	3.2	-1.1	-0.3	-1.8
Father’s age at death	1.4	1.8	3.2	1.2	-1.8	1.0
Exposure to tobacco smoke at home	1.4	1.5	2.8	-0.3	-1.3	-1.7
Miserableness	1.4	2.5	6.6	-0.1	-0.9	-2.6
HDL Cholesterol	1.3	2.2	6.1	2.5	0.2	0.7
LDL Cholesterol	1.3	2.0	4.0	-1.3	-0.6	-2.0
Diabetes (mother)	1.3	1.7	4.3	-2.1	0.3	-0.9
Hand grip strength (right)	1.3	3.4	4.5	2.1	1.8	1.6
Medication: Levothyroxine sodium	1.3	2.2	3.7	1.1	1.9	1.3
Weight	1.3	6.5	12.7	-3.6	-0.7	-2.5
Mouth/teeth dental problems: Dentures	1.3	2.1	6.2	-0.5	-0.1	-2.5
Ever highly irritable/argumentative for 2 days	1.3	1.5	3.0	-1.1	1.7	0.6
Emphysema/chronic bronchitis	1.3	1.5	1.7	-1.3	-1.1	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.2	-1.8	-0.2	1.3
Long-standing illness, disability or infirmity	1.3	1.9	3.6	-1.9	-0.3	-1.4
Commuting to job workplace: Walk	1.3	1.4	2.3	1.5	1.3	0.3
Medication: Blood pressure	1.3	2.4	4.6	-0.8	-1.4	-2.1
Myopia	1.3	1.8	4.7	-0.1	-2.2	-0.9
Depressed Affect (Nagel 2018)	1.2	2.6	5.8	-0.4	-1.3	-2.4
Number of live births	1.2	1.6	3.7	-1.1	-0.1	-1.9
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	6.5	2.5	1.4	1.9
Illnesses of mother	1.2	1.5	2.0	0.8	1.4	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	6.1	2.5	1.6	1.8
Peak expiratory flow (PEF)	1.2	2.8	3.1	1.8	1.5	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	2.3	1.5	1.5	-0.4
Shortness of breath walking on level ground	1.2	1.4	4.1	-2.0	-0.3	-0.3
Hypertension (Self-reported)	1.2	3.4	6.5	-1.6	-1.0	-2.5
High blood pressure	1.1	3.0	6.6	-1.3	-0.9	-2.6
Diabetes (self-reported)	1.1	1.7	4.5	-2.1	-0.6	-0.4
Medication: Amlodipine	1.1	1.5	1.8	-1.3	-1.2	-1.2
Mineral and other dietary supplements	1.1	1.5	3.0	-1.7	-0.2	-1.2
Average weekly champagne plus white wine intake	1.1	1.5	3.8	0.7	-0.5	-1.9
Vascular/heart problems diagnosed by doctor	1.1	3.0	6.4	1.2	1.1	2.5
Mean Putamen Volume	1.0	1.2	2.6	0.1	-1.6	-1.0
BMI	1.0	5.9	9.9	-2.7	-0.7	-3.1
Lung FVC	1.0	5.0	7.8	2.7	-0.2	2.8
Hand grip strength (left)	1.0	2.6	3.3	1.8	1.4	1.7
Sensitivity / hurt feelings	1.0	1.7	4.3	0.1	0.8	-2.1
Ever had hysterectomy (womb removed)	1.0	1.1	2.9	-1.7	0.4	0.4
Current tobacco smoking	1.0	1.7	2.7	-1.1	-1.1	-1.6
Fed-up feelings	1.0	1.8	3.0	-1.7	0.2	-1.6
Forced vital capacity (FVC)	1.0	3.7	5.6	2.2	0.7	2.4
Hip circumference	1.0	4.4	6.7	-2.6	-0.8	-2.4
Commuting to job workplace: Car/motor vehicle	1.0	1.1	1.8	1.3	-1.0	-0.8
Guilty feelings	1.0	1.5	3.2	-0.5	1.0	-1.8
Irritability	1.0	1.7	3.7	-1.9	-0.3	-1.2
Age started oral contraceptive pill	1.0	1.2	1.6	1.3	0.8	1.2
Bipolar Disorder or Schizophrenia	0.9	2.3	6.8	2.6	0.2	0.2
Worry (Nagel 2018)	0.9	2.0	5.9	2.4	0.0	-0.2
Alzheimer’s Disease (in father)	0.9	1.0	2.4	-0.6	1.6	0.1
Breast Cancer	0.9	2.1	3.4	1.8	1.3	1.0
Prostate Cancer	0.9	1.2	1.8	1.3	-0.3	1.4
HbA1C	0.9	1.0	2.6	-0.4	-1.6	0.4
Nervous feelings	0.9	1.6	4.5	2.1	0.5	0.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	3.2	0.2	0.5	1.8
Hair/balding pattern: Pattern 3	0.9	1.4	3.0	-1.7	0.4	1.0
Qualifications: A levels/AS levels or equivalent	0.9	2.0	3.3	1.1	1.8	1.3
Loud music exposure frequency	0.9	1.0	2.2	0.9	-0.1	1.5
Gout (self-reported)	0.9	1.2	2.6	-1.6	-1.1	-0.0
Forced vital capacity (FVC), Best measure	0.9	3.4	4.8	1.9	1.4	2.2
Migraine (self-reported)	0.9	1.1	2.7	1.6	-0.7	-0.1
Medication: Seretide 50 evohaler	0.9	1.1	1.9	-0.6	-1.4	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.9	1.7	0.4	0.5
Overall health rating	0.9	2.0	2.6	-1.6	-1.1	-1.4
Handedness (chirality/laterality): Left-handed	0.9	1.0	1.8	-1.3	-1.1	-0.2
Smoking status: Current	0.9	1.4	1.8	-1.1	-1.1	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	3.2	1.8	1.5	0.3
Wears glasses or contact lenses	0.9	1.0	2.2	1.5	-0.9	0.2
Financial situation satisfaction	0.9	1.2	2.9	-0.8	-1.7	0.0
Commuting to job workplace: Cycle	0.9	1.1	2.7	0.1	1.6	0.7
Bipolar Disorder (2011)	0.8	0.8	1.9	1.4	-0.4	0.6
Schizophrenia (2014)	0.8	1.8	3.9	2.0	-0.6	-1.1
Waist Hip Ratio (WHR)	0.8	3.5	6.9	-2.6	-1.3	-1.4
Number of treatments/medications taken	0.8	1.5	2.6	-1.6	-0.4	-1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.6	0.4	-1.6	-0.6
Systolic blood pressure, automated reading	0.8	2.3	3.5	-1.9	-0.8	-1.6
Angina	0.8	1.0	3.0	0.1	-0.4	-1.7
Medication: Co-codamol	0.8	0.9	1.8	-0.5	-0.8	-1.3
Medication: Metformin	0.8	1.2	3.2	-1.8	0.4	0.5
Heart attack	0.8	1.0	2.9	-0.3	-0.1	-1.7
Falls in the last year	0.8	1.1	1.7	0.6	-1.3	-1.1
Pulse rate	0.8	1.4	3.0	-1.7	1.0	0.4
Medication: Lansoprazole	0.8	0.9	1.8	-1.3	-0.2	-0.9
Angina (self-reported)	0.8	1.1	3.1	0.2	-0.4	-1.8
Leg pain on walking	0.8	1.0	1.8	-0.4	-1.3	1.0
Mood swings	0.8	1.5	2.2	-0.9	-1.2	-1.5
Diabetes diagnosed by doctor	0.8	1.3	3.8	-2.0	0.1	-0.0
Breast cancer (self-reported)	0.8	1.0	2.5	-0.3	0.6	-1.6
Number of self-reported non-cancer illnesses	0.8	1.4	2.6	-1.6	-1.2	-0.2
Alcohol drinker status: Never	0.8	0.9	1.5	-0.9	0.7	-1.2
Average weekly beer plus cider intake	0.8	1.1	1.7	-1.3	-1.3	-0.2
Bipolar Disorder (2018)	0.7	1.1	2.9	1.7	0.0	0.6
Schizophrenia (2018)	0.7	1.4	4.0	2.0	0.2	-0.2
Alzheimer’s Disease (including proxy)	0.7	1.0	1.7	-1.0	0.5	-1.3
Rheumatoid Arthritis	0.7	1.0	3.0	-1.7	-0.0	-0.0
Supplements: Zinc	0.7	0.7	1.3	0.9	-1.1	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.0	-2.0	-0.6	-0.8
Asthma	0.7	1.3	4.0	-2.0	-0.0	0.1
Prospective memory result	0.7	0.9	1.4	1.2	-0.7	-0.9
Length of working week for main job	0.7	0.8	1.5	-0.3	1.2	0.9
Breastfed as a baby	0.7	0.9	1.0	0.9	1.0	1.0
Hair/balding pattern: Pattern 4	0.7	1.6	2.8	0.9	-1.7	-1.1
Glaucoma (self-reported)	0.7	0.8	1.5	-0.1	-0.9	-1.2
Health satisfaction	0.7	1.0	2.1	0.3	-0.8	1.5
Neck or shoulder pain in last month	0.7	1.0	1.7	0.9	-1.3	0.6
Suffer from ‘nerves’	0.7	1.1	3.1	1.7	0.3	0.0
Friendships satisfaction	0.7	0.8	1.9	-0.7	-1.4	-0.2
Asthma (self-reported)	0.7	1.3	4.0	-2.0	-0.1	0.1
Diastolic blood pressure, automated reading	0.7	2.2	5.0	-2.2	0.4	-1.2
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.6	-0.4	-0.1	-1.6
Neuroticism (Nagel 2018)	0.6	1.5	3.9	0.6	-0.6	-2.0
Triglycerides	0.6	1.0	2.5	-1.6	-0.0	-0.6
Chronotype (morning person)	0.6	1.5	3.3	-1.0	0.3	-1.8
Stomach or abdominal pain in last month	0.6	0.7	1.6	1.3	-0.6	0.4
Hair/balding pattern: Pattern 2	0.6	0.8	1.5	0.4	0.9	1.2
Medication: Cholesterol lowering	0.6	1.0	1.8	-1.3	0.5	-0.9
Headache pain in last month	0.6	1.1	2.8	1.7	-0.7	-0.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	2.6	1.6	-0.7	0.3
High blood pressure (siblings)	0.6	0.9	2.7	1.6	0.1	-0.2
Wheeze or whistling in the chest in last year	0.6	1.1	1.9	-1.4	-1.1	0.4
Mean time to correctly identify matches	0.6	1.1	1.9	-1.2	-1.4	0.0
Had major operations	0.6	0.7	1.7	-0.2	0.7	1.3
Family relationship satisfaction	0.6	0.7	0.9	-0.9	-0.9	0.6
Supplements: Vitamin C	0.6	0.7	1.6	0.5	0.4	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.3	1.1	-0.2	-0.8
Eye problems/disorders: Glaucoma	0.6	0.7	1.0	-0.6	-1.0	-0.9
High cholesterol (Self-reported)	0.6	1.1	3.0	-0.5	0.5	-1.7
Medication: Paracetamol	0.6	0.9	1.1	-0.7	-1.0	-1.1
Cholesterol lowering medication	0.6	0.9	2.6	-0.1	-1.6	-0.4
Pain experienced in last month	0.6	0.9	2.2	-0.7	1.5	-0.4
Supplements: Calcium	0.6	0.7	1.3	1.1	-0.2	0.9
Schizophrenia vs Biploar Disorder	0.5	0.7	2.0	0.0	-0.2	-1.4
Alzheimer’s Disease (in mother)	0.5	0.6	1.1	-0.6	-0.4	-1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.3	-0.7	1.1	0.2
Blood Eosinophil Count	0.5	3.5	6.5	-1.9	2.5	-0.9
Respiratory disease	0.5	1.2	1.7	-1.3	1.1	-0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.6	0.8	0.6	0.8
Serious illness, injury or assault to yourself	0.5	0.6	1.0	-0.5	-1.0	-0.7
Supplements: Glucosamine	0.5	0.6	1.0	0.8	0.5	1.0
Number of incorrect matches in round	0.5	0.8	1.9	0.5	-1.4	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	1.1	-0.7	-0.2
Medication: Simvastatin	0.5	0.7	2.0	-1.4	-0.3	-0.1
Happiness	0.5	0.7	1.4	-0.2	-1.2	0.7
Tense / ‘highly strung’	0.5	0.9	1.4	0.7	0.9	-1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.2	0.4	-0.8	1.1
Comparative body size at age 10	0.5	1.4	3.6	-1.9	0.6	0.3
Number of full brothers	0.5	0.6	1.8	0.4	-0.0	-1.3
Number of children fathered	0.5	0.6	1.3	0.6	1.2	0.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	-1.3	0.1	-0.3
Knee pain experienced in last month	0.5	0.8	1.9	-0.4	-1.4	-0.4
Medication for cholesterol	0.5	0.8	1.4	-0.4	1.2	0.8
Osteoporosis (self-reported)	0.5	0.6	0.8	-0.7	0.7	0.9
Osteoarthritis (self-reported)	0.5	0.6	1.1	-0.8	-1.1	0.3
Medication: Gliclazide	0.5	0.6	1.2	0.6	-0.2	1.1
Mother’s age at death	0.5	0.6	1.2	1.1	0.4	-0.6
Medication: Lisinopril	0.5	0.6	1.2	-1.1	0.8	-0.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.7	1.3	-0.2	0.3
Fractured/broken bones in last 5 years	0.5	0.6	1.3	-0.3	-1.1	-0.7
Basal cell carcinoma (self-reported)	0.5	0.6	1.4	1.2	0.5	0.4
Body Mass Index (BMI) (2010)	0.4	0.6	1.5	-1.2	0.1	-0.4
Ulcerative Colitis	0.4	0.6	1.3	0.7	-0.0	1.1
Hypothyroidism (self reported)	0.4	0.9	1.5	-0.1	1.1	1.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.6	-1.3	0.5	0.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	1.2	-0.1	0.1
Maternal smoking around birth	0.4	0.5	1.0	-0.1	-0.8	-1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.1	-1.0	-0.5	0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.1	-0.5	0.6	1.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	0.5	-1.0	-0.5
Had other major operations	0.4	0.5	1.1	0.6	-1.1	0.2
Mouth/teeth dental problems	0.4	0.6	1.3	-0.5	0.5	1.1
Neuroticism score	0.4	0.8	2.2	0.1	-0.3	-1.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.7	0.7	0.5	0.9
Medication: Paracetamol	0.4	0.7	1.0	-0.3	-1.0	-1.0
Eye problems/disorders: None of the above	0.4	0.4	1.1	1.0	-0.3	0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.8	0.9	-0.1	-0.9
Age at last live birth	0.4	0.5	1.1	1.0	0.6	-0.4
Back pain experienced in last month	0.4	0.6	0.8	0.8	-0.9	0.6
Number of operations (self-reported)	0.4	0.6	1.6	0.3	-1.3	-0.1
Unable to work because of sickness or disability	0.4	0.5	0.9	-0.3	1.0	-0.6
Alcohol drinker status: Previous	0.4	0.5	1.2	-0.2	-0.5	1.1
Depression (Nagel 2018)	0.3	0.5	0.8	-0.7	-0.4	-0.9
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.9	-0.6	1.4	0.3
Crohns Disease (2017)	0.3	0.7	1.9	1.4	0.5	0.2
Irritable Bowel Disease (IBD)	0.3	0.8	1.9	1.4	0.3	0.6
Reaction Time	0.3	0.6	1.4	-1.2	-0.5	0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.7	-0.4	1.3	0.2
Age at First Birth	0.3	0.4	0.9	0.6	1.0	0.2
Crohns Disease (2012)	0.3	0.5	0.8	0.9	0.8	0.4
Lupus	0.3	0.4	0.6	-0.8	-0.8	-0.4
Allergy or Eczema	0.3	0.8	0.9	-0.9	0.8	0.9
Cardiovascular Disease	0.3	1.1	1.9	-1.1	-0.4	-1.4
Neuroticism	0.3	0.7	0.9	1.0	-0.7	-0.7
Average weekly spirits intake	0.3	0.4	0.8	-0.9	-0.1	-0.6
Medication for hormone replacement therapy	0.3	0.3	0.6	0.5	-0.8	-0.1
Diabetes (father)	0.3	0.4	0.5	-0.7	0.6	-0.6
Leg fat-free mass (left)	0.3	1.4	2.9	-1.7	-0.1	-1.1
Townsend deprivation index at recruitment	0.3	0.4	1.0	-1.0	0.2	0.4
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	-1.0	0.3	-0.3
Leg predicted mass (left)	0.3	1.4	3.0	-1.7	-0.1	-1.1
Past tobacco smoking	0.3	0.5	1.5	0.0	0.3	1.2
Medication: Ramipril	0.3	0.4	0.8	0.9	-0.1	0.6
Illnesses of siblings	0.3	0.5	1.1	-1.1	0.0	-0.5
Worrier / anxious feelings	0.3	0.6	1.6	1.3	-0.2	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	0.3	-0.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.9	0.1	-0.6
Lung cancer (father)	0.3	0.4	1.1	0.2	-0.1	-1.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.9	-0.4	0.9	0.2
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.3	0.6	-0.9
Worry too long after embarrassment	0.3	0.5	1.3	0.3	0.1	-1.2
Pulse wave peak to peak time	0.3	0.3	0.5	0.6	0.7	0.4
Qualifications: College or University degree	0.3	1.1	2.0	1.4	1.1	0.2
Medication for pain relief, constipation, heartburn	0.3	0.6	1.0	-1.0	0.3	0.8
Medication: Blood pressure	0.3	0.6	1.1	-0.8	1.0	-0.1
Average weekly red wine intake	0.3	0.5	0.6	0.8	0.8	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.2	-1.1	0.0	0.4
Medication: Aspirin	0.3	0.4	0.6	-0.6	0.8	0.4
Illnesses of father: High blood pressure	0.3	0.3	0.8	0.1	-0.9	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	-0.3	-0.7	-0.7
Ulcerative Colitis (UC)	0.2	0.4	0.9	1.0	0.0	0.4
Ovarian Cancer	0.2	0.3	0.6	0.3	-0.4	-0.8
Blood White Count	0.2	1.5	4.2	-0.5	0.2	-2.1
Heel T-Score	0.2	1.8	3.9	1.1	-0.5	-2.0
Smoking Status	0.2	0.4	1.1	-0.1	-0.4	-1.1
Lung FEV1/FVC ratio	0.2	0.8	1.7	0.8	0.5	-1.3
Relative age of first facial hair	0.2	0.5	0.7	-0.7	0.5	-0.8
Severe depression (siblings)	0.2	0.3	0.4	0.6	0.2	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.4	-1.2	-0.2	0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.9	-0.3	-0.1	0.9
Sitting height	0.2	1.1	2.0	0.6	0.9	1.4
Had menopause	0.2	0.3	0.7	0.8	0.2	0.4
Fluid intelligence score	0.2	0.5	0.7	0.7	0.8	0.5
Depression (self-reported)	0.2	0.2	0.5	0.7	-0.0	-0.3
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.6	-0.7	-0.2
Impedance of arm (left)	0.2	1.0	2.9	-0.2	1.7	0.4
Blood clot in the leg (DVT)	0.2	0.2	0.3	-0.2	-0.5	-0.6
Birth weight	0.2	0.5	1.4	0.0	-1.2	0.1
Medication: Ibuprofen	0.2	0.2	0.4	0.6	-0.0	-0.6
Arm predicted mass (right)	0.2	0.9	2.4	-1.6	0.1	-0.6
Number of full sisters	0.2	0.3	0.6	-0.8	-0.4	-0.3
Illnesses of father: Heart disease	0.2	0.2	0.4	0.5	-0.6	-0.3
Smoking status: Previous	0.2	0.3	0.7	-0.0	-0.2	-0.8
Leg fat-free mass (right)	0.2	1.0	2.5	-1.6	-0.0	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.4	-0.6	-0.3	-0.6
Leg predicted mass (right)	0.2	1.0	2.4	-1.6	-0.1	-0.7
Ever smoked	0.2	0.3	0.4	0.6	0.5	-0.5
Basal metabolic rate	0.2	1.3	3.0	-1.7	-0.5	-0.9
Arm fat-free mass (left)	0.2	1.2	2.0	-1.4	-0.5	-1.2
Risk taking	0.2	0.4	0.7	-0.9	-0.6	0.1
Ever depressed for a whole week	0.2	0.2	0.4	0.6	-0.3	-0.2
Arm predicted mass (left)	0.2	1.0	1.7	-1.3	-0.4	-1.1
Fasting Glucose	0.1	0.1	0.2	-0.4	0.4	0.1
Primary Biliary Cirrhosis	0.1	0.2	0.5	0.3	-0.7	0.0
Blood Platelet Count	0.1	0.8	1.2	-0.4	1.1	-1.0
Blood Red Count	0.1	1.1	2.8	0.6	1.7	-0.3
Height	0.1	1.0	1.5	-0.7	1.2	1.0
Systolic Blood Pressure	0.1	0.3	0.7	-0.5	-0.1	-0.9
Average weekly fortified wine intake	0.1	0.1	0.3	-0.6	-0.3	0.1
Relative age voice broke	0.1	0.2	0.3	0.5	-0.0	-0.5
Age when periods started (menarche)	0.1	0.3	0.5	-0.7	-0.4	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	0.1	-0.1	0.6
Allergy	0.1	0.3	0.7	0.8	-0.2	-0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.3	0.3	0.6
Trunk predicted mass	0.1	0.3	0.5	-0.7	-0.6	0.1
Arm fat-free mass (right)	0.1	0.8	1.8	-1.3	0.1	-0.7
Alcohol intake frequency.	0.1	0.1	0.2	0.4	-0.2	0.4
Comparative height size at age 10	0.1	0.4	0.8	-0.3	0.9	0.5
Medication: Aspirin	0.1	0.1	0.2	0.0	0.4	0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.1	0.4	0.3
Whole body fat-free mass	0.1	0.4	1.1	-1.1	-0.3	-0.3
Ever had bowel cancer screening	0.1	0.1	0.3	0.6	-0.1	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.4	0.3	0.4
Whole body water mass	0.1	0.5	1.2	-1.1	-0.4	-0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.4	-0.4	-0.6	-0.1
Medication: Atorvastatin	0.1	0.1	0.1	0.1	-0.2	-0.4
Impedance of whole body	0.1	0.5	1.5	-0.4	1.2	0.1
Hair Pigment	0.0	0.4	0.6	0.8	0.7	0.1
Tanning	0.0	0.3	0.5	-0.6	0.3	-0.7
Impedance of leg (right)	0.0	0.0	0.1	0.1	0.3	-0.2
Impedance of leg (left)	0.0	0.1	0.2	-0.4	0.3	-0.3
Impedance of arm (right)	0.0	0.1	0.2	-0.2	0.5	0.2
Trunk fat-free mass	0.0	0.2	0.4	-0.6	-0.6	0.1
Noisy workplace	0.0	0.0	0.1	-0.2	-0.2	0.2
Standing height	0.0	0.3	0.7	0.1	0.6	0.8
Pulse wave reflection index	0.0	0.0	0.1	0.4	0.1	-0.0
Age at first live birth	0.0	0.0	0.0	0.0	-0.2	0.1
Pulse rate, automated reading	0.0	0.1	0.2	-0.4	0.1	-0.0
Chest pain or discomfort	0.0	0.1	0.2	-0.1	0.1	-0.4
Heart disease (siblings)	0.0	0.0	0.1	-0.1	0.1	-0.3

Hub : Genes

OSBPL3

Models

Trait associations