Hub : Genes

OSCP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0420 0.0200 1.2e-02 0.039 0.010 0.019 0.011 0.029 1.5e-05 1.8e-02 2.2e-03 1.6e-02 1.6e-04
2 GTEx Brain Cerebellum 0.2260 0.0720 2.7e-03 0.179 NA 0.061 NA 0.139 5.5e-06 NA 7.1e-03 NA 6.9e-05
3 GTEx Cells Transformed fibroblasts 0.1010 0.0440 6.5e-03 0.009 NA -0.003 NA 0.007 6.3e-02 NA 5.9e-01 NA 9.5e-02
4 GTEx Esophagus Mucosa 0.2790 0.0560 3.1e-09 0.182 NA 0.163 NA 0.218 3.1e-12 NA 4.9e-11 NA 1.3e-14
5 GTEx Esophagus Muscularis 0.2130 0.0650 1.8e-04 0.095 NA 0.032 NA 0.067 2.2e-06 NA 4.8e-03 NA 7.0e-05
6 GTEx Nerve Tibial 0.1614 0.0416 1.7e-05 0.168 NA 0.142 NA 0.158 6.1e-12 NA 3.0e-10 NA 2.8e-11
7 GTEx Skin Not Sun Exposed Suprapubic 0.2320 0.0640 5.2e-04 0.032 NA 0.014 NA 0.019 6.8e-03 NA 5.1e-02 NA 3.1e-02
8 GTEx Skin Sun Exposed Lower leg 0.2040 0.0450 9.5e-08 0.121 NA 0.077 NA 0.097 3.2e-10 NA 6.2e-07 NA 2.2e-08
9 GTEx Testis 0.4860 0.0740 1.9e-09 0.301 NA 0.334 NA 0.353 7.6e-14 NA 1.6e-15 NA 1.7e-16
10 GTEx Thyroid 0.1420 0.0470 3.5e-04 0.094 NA 0.073 NA 0.100 1.2e-07 NA 3.1e-06 NA 4.3e-08
11 METSIM Adipose 0.0406 0.0191 1.0e-02 0.015 0.006 0.008 0.009 0.013 1.9e-03 3.5e-02 1.7e-02 1.6e-02 3.8e-03
12 ROSMAP Brain Pre-frontal Cortex 0.4575 0.0424 0.0e+00 0.515 0.477 0.500 0.512 0.515 2.7e-77 2.0e-69 4.9e-74 1.2e-76 4.0e-77
13 TCGA Kidney Renal Clear Cell Carcinoma 0.0447 0.0224 1.2e-03 0.015 0.016 0.014 NA 0.011 7.0e-03 5.8e-03 1.0e-02 NA 1.8e-02
14 TCGA Lung Adenocarcinoma 0.0363 0.0209 3.7e-03 0.013 0.017 0.009 NA 0.013 1.0e-02 4.2e-03 2.9e-02 NA 9.5e-03
15 TCGA Ovarian Serous Cystadenocarcinoma 0.0520 0.0280 5.8e-03 0.025 0.043 0.018 NA 0.021 7.9e-03 6.7e-04 2.2e-02 NA 1.3e-02
16 TCGA Thyroid Carcinoma 0.1060 0.0390 6.1e-07 0.045 0.070 0.054 NA 0.052 3.1e-05 2.1e-07 5.9e-06 NA 8.2e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 0.3 0.5 2.7 0.8 -0.7 1.6 0.2 -0.4 -0.8 -0.8 -0.4 0.9 -0.8 -0.1 -0.7 -0.2 -0.4 0.1 -0.2
Bipolar Disorder or Schizophrenia 0.3 0.7 7.1 0.8 -0.4 2.7 0.7 -0.2 -0.5 -0.3 0.4 0.6 -0.7 0.5 -0.5 -0.4 0.5 0.4 0.5
Depressed Affect (Nagel 2018) 1.0 2.1 7.8 2.4 -1.0 2.8 -1.2 -1.6 -1.0 -1.1 -0.8 0.6 -1.9 -0.6 -1.0 -2.2 -0.4 -0.9 -0.9
Depression (Nagel 2018) 0.3 0.4 1.4 1.0 -0.1 1.2 -0.8 -0.9 -0.1 -0.5 -0.3 -0.4 -0.7 -0.5 -0.1 -0.6 -0.3 -0.6 -0.9
Intelligence (Savage-Jansen 2018) 0.9 2.8 8.5 -1.1 1.4 -1.0 1.8 1.8 1.5 1.7 1.9 -1.3 1.3 1.7 1.3 2.9 1.5 2.0 1.7
Neuroticism (Nagel 2018) 0.8 1.9 12.7 1.9 -0.4 3.6 -1.4 -1.2 -0.4 -1.3 -0.7 -0.2 -1.4 -0.4 -0.5 -1.9 -0.8 -1.1 -0.8
Schizophrenia (2018) 0.2 0.5 4.3 0.4 0.1 2.1 0.7 0.0 -0.1 0.3 0.8 -0.0 -0.2 0.8 -0.0 -0.4 0.9 0.4 0.8
Schizophrenia vs Biploar Disorder 0.5 0.6 2.6 0.3 -0.3 -1.6 -1.6 -0.7 -0.3 -0.7 -0.5 -0.2 -0.2 -0.7 -0.3 -0.8 -0.8 -1.1 -0.8
Worry (Nagel 2018) 0.3 0.7 5.7 0.8 0.2 2.4 -1.1 -0.4 0.2 -0.8 -0.4 -0.7 -0.4 -0.2 0.1 -1.0 -0.5 -0.8 -0.5
Alzheimer’s Disease (in mother) 1.7 2.0 4.2 -2.0 1.8 -0.5 1.0 1.5 1.8 1.5 1.5 -2.1 1.7 1.4 1.6 1.0 0.8 0.5 0.9
Alzheimer’s Disease (in father) 1.6 1.7 4.2 -0.8 0.9 1.9 1.6 0.8 0.9 2.1 1.6 -0.8 0.7 1.7 0.8 0.7 1.8 1.3 1.4
Alzheimer’s Disease (including proxy) 1.2 1.7 3.0 -1.2 1.2 0.6 1.2 1.1 1.3 1.7 1.7 -1.6 1.1 1.4 1.0 1.1 1.6 1.2 1.4
Crohns Disease (2017) 0.7 1.6 5.4 2.3 -1.3 1.4 -0.0 -0.6 -1.4 -0.2 -0.5 1.5 -2.2 -0.3 -1.4 -2.1 -0.1 -0.7 -0.2
Irritable Bowel Disease (IBD) 1.5 3.7 7.2 2.1 -2.1 0.9 -1.4 -1.6 -2.2 -1.7 -1.9 2.2 -2.5 -1.6 -2.2 -2.7 -1.2 -1.9 -1.7
Ulcerative Colitis (UC) 1.6 3.1 4.7 0.8 -1.7 0.2 -2.1 -1.8 -1.8 -2.2 -2.1 1.6 -1.4 -1.8 -1.7 -2.0 -1.4 -2.0 -2.1
Major Depression (MDD) 1.3 1.5 3.0 -0.8 1.2 1.1 0.9 0.7 1.2 1.1 1.6 -1.4 1.0 1.7 1.2 0.8 1.6 1.4 1.5
Reaction Time 0.5 0.9 1.7 0.4 -1.2 0.9 -0.7 -1.0 -1.2 -1.3 -1.0 1.1 -0.6 -0.6 -1.1 -1.2 -0.9 -0.8 -0.8
Verbal and Numeric Reasoning (VNR) 0.9 2.1 7.5 -1.2 0.7 0.1 1.7 1.2 0.7 1.1 1.6 -0.5 1.1 1.4 0.6 2.7 2.0 2.2 1.5
Breast Cancer 0.6 1.4 3.3 -0.7 1.8 -1.2 0.3 1.6 1.8 0.6 0.5 -1.7 1.2 0.4 1.8 0.7 -1.2 -0.8 -0.5
Ovarian Cancer 0.2 0.3 1.1 0.2 -0.7 -0.2 -0.8 -1.1 -0.7 -0.7 -0.3 0.4 -0.7 -0.5 -0.7 -0.5 0.3 0.1 -0.4
Prostate Cancer 0.9 1.2 5.0 -0.2 0.6 0.5 1.3 0.4 0.6 1.8 1.5 -0.5 0.4 1.6 0.5 0.7 2.2 1.3 0.8
Age at First Birth 0.0 0.0 0.1 -0.2 -0.1 -0.3 0.0 0.0 0.0 0.2 0.0 0.0 -0.1 -0.1 -0.1 0.3 -0.1 0.3 0.1
Bipolar Disorder (2011) 0.3 0.3 2.1 0.0 -0.1 0.9 0.5 -0.2 -0.1 0.1 0.2 0.0 -0.1 0.5 -0.1 -1.4 0.2 -0.7 -0.2
Body Mass Index (BMI) (2010) 1.1 1.6 3.0 1.7 -1.7 1.6 -0.0 -1.7 -1.6 -0.5 -0.2 1.6 -1.7 -0.1 -1.4 -1.1 1.3 0.7 0.5
Coronary Artery Disease (CAD) 0.4 0.5 1.3 0.8 -0.7 1.1 0.0 -0.7 -0.8 -0.3 0.4 0.0 -0.8 0.4 -0.6 -0.2 1.1 0.8 0.7
Crohns Disease (2012) 0.9 1.4 3.7 1.8 -1.4 0.8 -0.2 -1.2 -1.5 -0.5 -0.7 1.4 -1.9 -0.9 -1.6 -1.4 -0.1 -0.3 -0.3
Mean Putamen Volume 2.8 3.2 5.6 -1.5 2.2 -0.0 1.8 1.7 2.3 2.0 2.1 -2.4 2.0 2.0 2.2 1.0 1.3 0.9 1.4
Fasting Glucose 0.3 0.3 1.3 -1.1 0.7 -0.2 0.2 0.7 0.6 0.4 0.1 -0.5 1.0 0.1 0.8 0.2 -0.5 -0.2 -0.1
HbA1C 0.2 0.2 0.9 -0.2 0.2 0.9 0.9 0.6 0.3 0.5 0.5 -0.0 0.3 0.3 0.1 0.2 0.2 0.2 0.5
HDL Cholesterol 1.6 2.6 4.2 -1.8 1.6 0.1 1.6 1.8 1.7 1.2 1.7 -1.5 1.9 1.9 1.7 2.1 1.3 1.3 1.6
LDL Cholesterol 1.0 1.5 3.3 1.5 -1.5 -0.2 -0.8 -1.0 -1.6 -0.9 -1.4 1.8 -1.7 -1.5 -1.6 -0.8 -0.4 -0.2 -0.8
Lupus 0.2 0.3 1.0 0.5 -0.2 -0.7 -0.2 0.5 -0.2 0.1 -0.5 0.5 -0.6 -0.2 -0.2 -1.0 -0.3 -0.6 -0.9
Neuroticism (2016) 0.5 0.8 7.6 0.5 0.1 2.8 -0.3 -0.2 -0.0 -0.1 -0.5 -0.1 -0.5 0.1 -0.2 -0.9 -0.8 -1.2 -0.8
Primary Biliary Cirrhosis 1.6 2.2 7.2 0.9 -0.8 -0.5 -2.0 -1.1 -0.8 -0.9 -1.6 0.4 -0.9 -1.4 -0.8 -2.7 -1.6 -2.6 -2.2
Rheumatoid Arthritis 0.7 1.0 2.2 -1.5 0.8 -0.9 1.3 0.6 0.7 1.0 1.1 -0.8 1.2 1.1 0.8 0.9 0.8 1.1 0.9
Schizophrenia (2014) 0.2 0.4 2.0 1.0 -0.4 1.4 -0.1 -0.4 -0.5 -0.6 0.1 0.4 -0.8 0.3 -0.4 -1.2 0.2 -0.3 0.1
Triglycerides 2.3 3.8 7.2 1.9 -2.3 1.7 -1.0 -2.1 -2.3 -1.6 -2.0 2.4 -2.3 -2.0 -2.1 -2.7 -0.9 -1.3 -1.5
Type 2 Diabetes (T2D) (2012) 0.7 0.8 3.6 0.9 -0.8 1.4 -0.3 -0.8 -0.8 -0.6 -0.7 0.7 -1.0 -0.7 -0.7 -1.9 -0.6 -1.0 -0.2
Ulcerative Colitis 2.4 3.5 5.6 0.7 -1.9 -0.0 -2.2 -1.8 -1.9 -2.3 -2.4 1.8 -1.3 -2.0 -1.9 -2.1 -1.5 -2.2 -2.3
Blood Eosinophil Count 0.3 2.2 5.0 -1.8 2.2 0.4 0.8 1.9 2.2 0.7 1.0 -2.2 2.0 1.4 2.2 0.7 -0.2 -0.3 0.1
Blood Platelet Count 0.3 3.0 7.9 2.8 -2.1 1.6 1.2 -1.2 -2.3 0.4 -0.1 2.7 -2.8 -0.4 -2.2 -0.4 1.3 1.2 1.4
Blood Red Count 0.0 0.2 0.7 0.3 -0.6 0.5 -0.2 -0.3 -0.6 -0.5 -0.4 0.8 -0.4 -0.3 -0.6 0.0 0.5 0.8 0.2
Blood White Count 3.7 27.3 158.8 6.2 -3.6 3.6 -2.1 -4.2 -3.6 -2.0 -3.4 2.8 -5.6 -1.2 -3.6 -12.6 -1.9 -7.8 -6.8
Heel T-Score 0.4 3.1 6.4 1.6 -2.5 1.0 -1.1 -2.5 -2.5 -1.3 -1.5 2.5 -2.1 -1.4 -2.4 -1.6 -0.2 0.1 0.1
BMI 0.1 0.4 1.3 0.5 0.3 1.2 0.8 0.3 0.3 0.8 0.7 -0.5 -0.3 0.7 0.3 -0.6 0.8 0.1 0.5
Height 0.1 2.4 5.6 2.2 -0.8 -0.3 -2.1 -1.5 -0.7 -2.1 -1.7 0.3 -1.6 -1.8 -0.8 -1.5 -0.9 -1.7 -2.4
Waist Hip Ratio (WHR) 0.0 0.2 0.8 0.1 -0.0 0.9 -0.4 -0.2 -0.1 -0.0 -0.3 0.0 -0.1 -0.8 -0.1 0.4 -0.8 -0.2 -0.1
Systolic Blood Pressure 0.0 0.2 0.6 -0.5 0.1 -0.6 -0.0 0.2 0.2 0.3 -0.4 -0.3 0.4 -0.1 0.1 -0.3 -0.8 -0.8 -0.4
Smoking Status 0.4 0.9 7.6 -0.6 0.9 2.8 0.7 0.3 0.9 0.4 0.6 -1.0 0.7 0.6 0.9 0.3 0.1 0.1 0.9
Allergy or Eczema 0.1 0.3 0.9 0.2 0.7 -0.1 -0.4 0.8 0.7 -0.5 -0.1 -0.8 0.4 0.3 0.6 -0.2 -0.8 -1.0 -0.9
Cardiovascular Disease 0.1 0.5 1.1 0.3 -0.6 -0.2 -0.9 -1.0 -0.6 -1.0 -0.7 0.2 -0.4 -1.0 -0.6 -0.6 -0.2 -0.6 -0.9
Hypothyroidism (self reported) 0.3 0.7 2.0 -0.4 -0.5 0.4 -0.5 -0.7 -0.6 -0.8 -1.1 0.4 -0.1 -1.2 -0.5 -1.1 -1.3 -1.4 -1.2
Respiratory disease 0.3 0.6 2.7 1.4 -0.7 1.6 0.5 -0.5 -0.7 -0.4 0.1 0.9 -0.9 0.5 -0.8 -0.6 0.7 0.2 0.4
Type 2 Diabetes (T2D) (2018) 0.3 0.5 2.6 0.6 -0.5 0.1 -0.3 -0.3 -0.6 -0.9 -0.7 0.6 -0.7 -0.9 -0.5 -1.6 -0.6 -0.6 -0.7
Lung FEV1/FVC ratio 0.8 4.0 6.9 1.2 -1.9 -2.1 -2.6 -2.2 -1.9 -1.8 -2.3 1.6 -1.5 -1.9 -2.1 -2.6 -2.4 -2.0 -1.3
Lung FVC 0.2 1.0 2.3 -0.3 1.2 1.5 1.0 1.1 1.3 1.0 1.1 -1.1 0.7 1.1 1.2 0.5 1.0 0.9 0.7
Neuroticism 0.6 1.4 8.9 1.2 -0.1 3.0 -1.6 -0.8 -0.1 -1.3 -0.9 -0.4 -0.9 -0.7 -0.2 -1.2 -1.1 -1.2 -1.1
Chronotype (morning person) 0.9 2.1 4.5 1.5 -2.0 -1.1 -0.9 -2.1 -2.0 -0.9 -0.8 1.7 -1.8 -0.4 -1.9 -2.0 0.8 -0.4 -0.3
Hair Pigment 0.0 1.4 5.1 0.6 -0.7 -0.7 -1.4 -0.5 -0.7 -1.8 -1.6 0.8 -0.5 -1.5 -0.6 -1.1 -2.2 -1.4 -0.9
Tanning 0.2 2.2 3.6 -1.3 1.5 0.4 1.5 1.6 1.6 1.8 1.4 -1.4 1.4 1.8 1.4 1.9 1.3 1.4 1.4
Hand grip strength (left) 0.3 0.7 2.3 0.8 -0.4 1.0 -0.7 -0.8 -0.4 -1.4 -1.0 0.5 -0.7 -1.5 -0.4 0.9 -0.9 0.0 -0.3
Number of treatments/medications taken 0.2 0.4 1.9 0.9 0.3 1.4 0.9 0.3 0.4 0.6 0.6 -0.3 -0.3 0.9 0.2 -0.2 0.9 0.3 0.2
Average weekly spirits intake 2.4 3.0 6.1 1.7 -1.2 -1.2 -2.2 -1.2 -1.2 -2.5 -2.2 1.1 -1.3 -2.0 -1.2 -1.9 -1.8 -2.0 -2.3
Sensitivity / hurt feelings 1.8 3.1 5.1 2.2 -1.4 2.3 -1.9 -1.9 -1.3 -2.2 -1.8 1.0 -1.8 -1.3 -1.4 -2.2 -1.7 -1.8 -1.4
Frequency of depressed mood in last 2 weeks 0.3 0.5 5.6 0.8 0.0 2.4 -0.2 -0.7 0.0 0.1 0.1 -0.3 -0.5 -0.2 -0.0 -0.3 0.5 0.0 -0.2
Hearing difficulty/problems: Yes 1.0 1.6 3.7 -1.5 0.9 1.1 1.7 1.3 0.8 1.5 1.4 -0.6 1.0 1.1 0.8 1.1 1.1 1.5 1.9
Relative age of first facial hair 0.4 0.8 6.7 0.7 -0.5 2.6 1.2 0.2 -0.5 -0.4 -0.1 0.9 -0.5 -0.2 -0.5 0.6 -0.1 1.0 0.9
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.8 0.0 0.6 0.7 -0.3 0.3 0.6 0.2 0.3 -0.9 0.2 0.3 0.4 -0.2 0.3 -0.2 -0.5
Ever used hormone-replacement therapy (HRT) 1.8 2.3 5.0 -2.2 2.1 -1.2 0.7 1.8 2.1 1.2 0.7 -2.2 2.1 1.0 2.0 0.4 -0.8 -0.9 -0.1
Ever had hysterectomy (womb removed) 1.4 1.6 3.1 -1.2 1.4 -1.0 1.3 1.4 1.3 1.8 1.5 -1.3 1.3 1.3 1.4 0.9 0.7 0.8 1.0
Systolic blood pressure, automated reading 0.1 0.4 1.7 -0.3 0.6 -0.1 1.1 0.9 0.6 1.3 0.5 -0.6 0.1 0.6 0.5 -0.3 0.4 0.0 -0.0
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 3.8 1.0 -1.4 2.0 0.2 -1.0 -1.4 0.2 -0.2 1.6 -1.2 -0.4 -1.4 -0.7 0.8 0.7 0.6
Angina 1.6 2.1 3.1 -1.6 1.7 -0.6 1.1 1.7 1.8 1.6 1.5 -1.6 1.7 1.6 1.8 1.7 0.6 0.7 1.1
Medication for hormone replacement therapy 0.8 0.9 2.7 -0.6 1.0 -0.8 1.2 1.1 1.0 1.6 1.0 -0.8 0.7 1.1 0.9 0.6 0.7 0.5 0.3
Vitamin and mineral supplements 3.7 5.1 10.0 -3.0 2.9 -2.5 1.1 2.3 2.8 1.9 2.0 -3.2 2.8 1.4 3.0 2.2 0.5 0.9 0.6
Supplements: Zinc 0.2 0.2 0.9 0.2 0.4 0.5 -0.5 0.3 0.4 -0.3 -0.1 -0.4 0.1 0.2 0.5 -0.2 -0.2 -0.7 -1.0
Medication: Co-codamol 0.3 0.3 1.6 1.3 -0.5 0.4 -0.2 -0.3 -0.5 -0.1 -0.2 0.6 -1.0 0.0 -0.5 -0.6 0.7 0.1 -0.2
Medication: Metformin 0.9 1.3 2.1 1.1 -1.2 -0.3 -1.1 -1.4 -1.2 -1.5 -1.1 1.0 -1.2 -1.3 -1.3 -1.3 -0.7 -0.8 -0.8
Diabetes (father) 0.7 0.8 2.4 0.6 -0.5 0.5 -0.5 -0.7 -0.6 -1.1 -1.0 0.5 -0.7 -0.7 -0.6 -1.5 -1.2 -1.3 -1.5
Diabetes (mother) 1.7 2.1 5.9 -0.5 0.2 1.6 2.3 0.2 0.1 1.8 1.9 -0.2 0.3 1.5 0.2 1.0 2.4 2.2 2.1
Severe depression (siblings) 1.0 1.2 3.4 -1.4 1.4 -0.4 0.7 1.3 1.4 0.6 0.7 -1.2 1.4 0.5 1.4 1.8 -0.2 0.6 0.5
Pack years adult smoking proportion 0.3 0.4 1.1 -1.0 0.7 1.1 0.4 0.4 0.8 0.6 0.4 -0.9 0.9 0.3 0.7 0.8 0.2 -0.1 -0.2
Impedance of leg (right) 0.1 0.4 1.5 0.3 -1.1 0.1 -0.5 -0.8 -1.0 -0.2 -0.7 1.2 -0.3 -0.2 -1.1 -0.2 -0.5 0.0 0.1
Leg fat-free mass (left) 0.1 0.5 2.5 0.2 1.2 0.4 0.3 0.6 1.2 0.2 0.7 -1.6 0.3 0.2 1.3 0.2 0.3 -0.3 -0.1
Trunk fat percentage 1.5 5.9 9.9 -2.0 2.8 0.1 2.7 3.0 2.7 3.1 2.8 -2.8 2.4 2.7 2.8 1.7 1.5 1.5 2.2
Hand grip strength (right) 0.2 0.4 3.0 -0.3 0.7 0.2 -0.2 0.5 0.7 -0.5 -0.1 -0.6 0.4 -0.6 0.7 1.7 -0.4 0.5 0.3
Townsend deprivation index at recruitment 0.5 0.8 1.9 -1.1 0.8 0.9 0.9 0.7 0.8 1.1 1.0 -0.8 1.0 1.4 0.8 -0.4 0.3 0.1 1.2
Current tobacco smoking 0.5 0.8 3.0 -0.3 0.0 1.3 0.9 -0.4 0.0 0.7 0.9 -0.1 0.0 0.6 0.0 0.7 1.7 1.5 1.6
Average weekly fortified wine intake 0.4 0.4 1.5 -1.2 0.2 -0.1 -0.2 0.5 0.1 -0.5 -0.6 -0.1 0.6 -0.3 0.1 -0.8 -0.9 -1.1 -1.2
Maternal smoking around birth 5.3 7.7 11.4 -2.1 2.8 1.1 3.3 2.8 2.9 3.0 3.4 -2.7 2.5 3.3 2.9 3.1 2.4 2.7 2.9
Fed-up feelings 0.8 1.4 12.4 1.4 -0.9 3.5 0.2 -1.6 -0.9 0.2 0.3 0.7 -1.1 0.2 -0.8 -0.5 1.1 0.7 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.2 0.5 0.6 0.2 -0.6 0.0 0.6 -0.0 -0.1 -0.9 -0.0 -0.2 0.7 -0.4 -0.5 -0.8 -1.1
Relative age voice broke 1.8 2.7 7.1 -1.8 1.8 0.6 2.0 1.9 1.7 1.0 1.6 -1.6 1.9 1.1 1.7 2.7 0.3 1.6 1.4
Taking other prescription medications 0.6 0.9 2.5 -0.2 1.3 0.5 0.7 1.1 1.3 0.7 1.0 -1.5 0.8 1.6 1.2 -0.2 0.7 -0.2 0.1
Age when periods started (menarche) 1.0 2.5 6.2 -0.8 1.0 1.9 2.2 1.0 1.0 2.2 2.0 -0.7 0.7 1.8 1.1 0.7 2.5 1.7 1.8
Bilateral oophorectomy (both ovaries removed) 2.2 2.5 8.0 -0.7 0.6 1.4 2.2 0.9 0.5 1.7 2.0 -0.4 0.5 1.1 0.6 1.9 1.9 2.7 2.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.8 -0.4 -0.5 0.1 -0.8 -0.5 -0.4 -0.9 -0.6 0.4 0.1 -0.3 -0.4 -0.5 -0.4 -0.5 -0.7
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.1 -0.1 0.6 -0.4 -0.5 0.3 0.6 -0.4 -0.2 -0.8 0.3 0.2 0.6 -0.3 -1.0 -1.0 -0.6
Qualifications: CSEs or equivalent 0.5 0.6 1.7 -0.5 1.2 0.2 0.2 1.0 1.2 0.4 0.4 -1.3 1.1 0.4 1.1 0.8 -0.8 0.1 0.4
Serious illness, injury or assault to yourself 0.7 0.8 2.8 -0.6 0.9 1.7 0.8 0.5 0.9 0.9 1.1 -1.1 0.6 1.2 0.8 0.6 0.9 0.6 0.9
High blood pressure 0.2 0.5 2.0 -0.7 0.7 0.1 0.6 0.1 0.6 1.4 1.0 -0.9 0.7 0.7 0.7 -0.0 1.1 0.4 0.3
Hayfever, allergic rhinitis or eczema 0.2 0.5 2.2 0.3 0.2 0.2 -0.5 0.2 0.2 -0.8 -0.6 -0.3 0.1 0.1 0.1 -0.7 -1.2 -1.5 -1.4
Multivitamins +/- minerals 2.6 3.3 6.2 2.3 -2.3 2.0 -1.1 -1.8 -2.2 -1.4 -1.6 2.5 -2.3 -1.3 -2.4 -2.1 -0.4 -1.0 -0.6
Stomach or abdominal pain in last month 0.8 1.0 3.8 -0.8 1.2 2.0 0.4 0.7 1.1 1.1 1.1 -1.4 0.8 1.1 1.2 0.6 0.6 -0.1 -0.2
Supplements: Glucosamine 0.4 0.5 6.3 0.2 -0.0 2.5 0.2 0.4 0.0 -0.0 -0.4 0.2 -0.3 -0.1 -0.1 -0.3 -0.4 -0.4 -0.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.1 0.6 -0.6 1.0 -0.5 -1.0 -0.6 -0.0 -0.1 0.3 -0.7 0.0 -0.6 -0.5 0.6 0.4 0.2
Medication: Atenolol 1.1 1.4 3.8 0.1 -0.8 -0.8 -1.6 -1.1 -0.8 -1.9 -1.6 0.6 -0.3 -1.9 -0.7 -0.0 -1.9 -1.1 -1.4
Medication: Levothyroxine sodium 0.8 1.4 4.5 -0.2 -0.4 0.3 -0.8 -0.6 -0.5 -1.3 -1.5 0.4 -0.2 -1.2 -0.5 -1.7 -1.8 -2.1 -2.1
Sitting height 0.8 5.4 11.1 2.1 -1.8 -0.4 -3.0 -2.1 -1.8 -2.7 -3.1 1.8 -1.8 -3.3 -1.8 -1.6 -2.5 -2.6 -2.9
Chronic bronchitis/emphysema (father) 0.9 1.0 2.1 -1.1 0.7 -0.3 1.5 0.8 0.7 0.9 1.2 -0.6 0.9 0.9 0.7 1.4 1.1 1.3 1.4
High blood pressure (mother) 0.6 0.8 1.5 -0.7 0.9 -1.1 1.0 0.6 0.9 1.2 1.2 -0.9 0.9 1.0 1.0 0.8 0.9 0.5 0.5
Body mass index (BMI) 1.0 4.5 6.6 -1.6 2.4 0.7 2.5 2.3 2.3 2.5 2.6 -2.5 1.9 2.4 2.5 1.4 1.6 1.6 2.2
Impedance of leg (left) 0.2 0.9 2.3 0.5 -1.4 -0.1 -0.8 -1.2 -1.4 -0.6 -1.1 1.5 -0.7 -0.7 -1.5 -0.3 -0.6 -0.1 -0.2
Leg predicted mass (left) 0.1 0.6 2.6 0.2 1.3 0.4 0.3 0.6 1.2 0.2 0.7 -1.6 0.3 0.2 1.3 0.3 0.4 -0.3 -0.1
Trunk fat mass 0.8 3.4 5.5 -1.3 2.3 0.3 2.0 2.2 2.2 2.3 2.2 -2.4 1.7 1.9 2.3 1.2 1.2 1.1 1.6
Waist circumference 0.5 1.7 2.8 -0.5 1.6 0.7 1.5 1.4 1.4 1.6 1.7 -1.6 0.9 1.2 1.6 0.9 1.1 1.1 1.3
Number of incorrect matches in round 1.0 1.6 5.1 2.3 -1.3 0.1 -1.1 -1.4 -1.3 -1.2 -1.2 1.2 -1.8 -1.1 -1.3 -1.0 -1.3 -0.8 -0.4
Past tobacco smoking 0.2 0.4 3.6 0.0 -0.4 -1.9 0.1 0.1 -0.4 0.5 0.4 0.6 -0.1 0.1 -0.4 0.2 1.2 0.8 0.1
Alcohol usually taken with meals 0.7 1.2 2.9 0.8 -1.5 0.3 -1.5 -1.7 -1.4 -1.3 -1.2 1.3 -1.0 -0.7 -1.4 -0.5 -0.3 -0.3 -0.6
Nervous feelings 0.2 0.4 2.4 0.8 0.1 1.5 -0.5 -0.3 0.1 -0.6 -0.2 -0.3 -0.4 -0.0 0.0 -1.0 -0.6 -0.6 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 4.4 -0.7 1.3 2.1 0.4 0.5 1.4 0.7 0.9 -1.7 1.0 1.1 1.4 0.4 0.8 0.0 -0.1
Hearing difficulty/problems with background noise 0.5 0.8 3.0 -1.1 0.5 1.7 1.1 1.0 0.4 0.8 0.8 -0.1 0.8 0.4 0.5 1.1 0.4 0.9 1.2
Hair/balding pattern: Pattern 2 0.3 0.3 3.2 0.1 -0.5 -1.8 -0.7 -0.2 -0.5 -0.3 -0.4 0.6 -0.1 -0.4 -0.4 -0.0 0.0 -0.2 -0.5
Had menopause 0.4 0.5 1.5 -0.3 0.5 0.4 1.2 0.7 0.5 1.1 0.7 -0.4 0.2 1.2 0.4 -1.0 1.0 -0.1 0.4
Had other major operations 0.9 1.1 3.6 -0.1 0.1 1.9 1.5 -0.1 0.2 0.9 1.3 -0.2 0.2 1.7 0.0 -0.2 1.6 1.1 1.6
Forced vital capacity (FVC) 0.2 0.6 2.2 1.5 -0.6 0.6 -0.6 -0.8 -0.6 -1.0 -0.6 0.7 -1.1 -1.2 -0.6 0.2 0.5 0.4 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.7 -0.0 -0.8 0.6 -0.5 -0.9 -0.8 -0.6 -0.3 0.6 -0.4 -0.1 -0.8 -0.2 0.5 0.5 0.3
Ever unenthusiastic/disinterested for a whole week 1.8 2.2 7.4 -1.5 1.0 2.7 1.3 0.5 1.0 1.7 1.7 -1.1 1.3 1.5 1.1 1.8 1.3 1.4 1.4
Qualifications: None of the above 0.4 1.0 3.0 1.7 -1.1 0.7 0.2 -1.1 -1.1 -0.5 -0.4 1.1 -1.7 -0.3 -1.1 -1.4 0.5 -0.1 -0.4
Financial difficulties in last 2 years 1.8 2.5 8.1 0.1 0.3 2.4 1.7 0.4 0.4 1.8 1.9 -0.2 0.3 1.4 0.4 1.8 2.8 2.5 2.1
Mouth/teeth dental problems 0.1 0.2 1.8 -0.4 0.0 -1.4 -0.5 0.0 0.1 -0.1 -0.4 -0.0 0.3 0.0 -0.0 -0.3 -0.4 -0.5 -0.7
Heart attack 0.6 0.8 1.6 -0.8 0.8 0.3 1.1 0.6 0.8 0.8 1.1 -0.8 0.7 1.2 0.9 1.3 1.0 0.6 1.0
Allergy 0.2 0.3 1.5 -0.1 -0.5 -0.1 -0.1 -0.4 -0.6 0.4 0.0 0.7 -0.4 -0.9 -0.4 0.7 0.7 1.2 0.8
Pain all over the body in last month 0.1 0.1 0.2 -0.5 -0.4 0.2 -0.1 -0.3 -0.5 -0.4 -0.4 0.3 -0.0 -0.4 -0.3 -0.4 -0.4 -0.3 -0.3
Diabetes (self-reported) 0.3 0.4 1.0 0.5 -0.9 0.4 -0.1 -0.7 -1.0 -0.5 -0.3 1.0 -0.7 -0.8 -0.9 -0.2 0.2 0.6 0.4
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 3.5 -1.6 1.7 0.5 1.2 1.9 1.6 0.9 0.7 -1.5 1.5 0.7 1.6 1.0 -0.2 -0.1 -0.2
Medication: Ramipril 0.3 0.4 0.9 -1.0 0.5 -0.3 0.4 -0.2 0.4 0.5 0.9 -0.9 0.6 0.6 0.5 0.4 0.9 0.2 0.7
Medication: Simvastatin 1.9 2.8 4.0 1.6 -1.9 -1.4 -1.6 -1.5 -1.9 -1.9 -1.9 1.9 -1.7 -2.0 -2.0 -1.5 -0.9 -1.2 -1.6
Fluid intelligence score 1.4 2.8 6.0 -1.1 0.9 -0.0 2.3 1.7 0.9 1.8 2.0 -0.5 1.1 2.0 0.9 2.4 2.4 2.3 2.0
Illnesses of siblings 0.2 0.3 1.0 0.7 -0.6 0.5 0.1 -0.7 -0.5 0.3 -0.1 0.6 -0.8 -0.3 -0.6 -0.7 1.0 0.1 -0.4
Neuroticism score 1.1 2.2 8.6 1.5 -0.5 2.9 -2.1 -1.5 -0.5 -1.8 -1.3 -0.0 -1.2 -1.1 -0.5 -1.7 -1.6 -1.7 -1.3
Weight 0.3 1.6 3.4 -0.4 1.6 0.9 1.2 1.3 1.6 1.3 1.5 -1.8 0.9 1.1 1.7 0.8 1.1 0.8 1.0
Impedance of arm (right) 0.1 0.7 2.1 -0.8 0.7 -1.3 0.7 1.2 0.6 1.4 0.8 -0.3 1.0 0.7 0.6 0.6 0.0 0.6 0.7
Arm fat percentage (right) 1.7 6.6 10.8 -2.2 3.0 0.1 2.9 3.2 2.9 3.3 3.0 -2.9 2.6 2.8 3.0 1.7 1.5 1.7 2.3
Trunk fat-free mass 0.3 1.6 3.6 1.9 -0.4 0.8 -1.6 -1.2 -0.4 -1.8 -1.2 -0.1 -1.3 -1.6 -0.4 -1.2 -0.8 -1.5 -1.7
Hip circumference 0.6 2.7 4.6 -0.8 2.1 0.1 1.9 2.1 2.0 1.9 1.9 -2.0 1.3 1.8 2.1 1.1 1.1 1.1 1.1
Time employed in main current job 0.9 1.1 4.9 -0.2 0.7 -2.2 -1.1 0.2 0.7 -0.3 -0.7 -1.0 0.2 -0.4 0.5 -1.2 -1.6 -1.6 -1.1
Alcohol intake versus 10 years previously 0.4 0.6 2.7 0.3 -0.9 0.6 -0.1 -0.9 -1.0 -0.5 -0.3 1.0 -0.6 -0.6 -0.8 -1.6 -0.1 -0.4 0.7
Father’s age at death 0.3 0.5 1.5 -0.4 -0.7 0.2 -1.2 -0.8 -0.7 -0.6 -0.8 0.5 -0.1 -0.8 -0.8 0.0 -0.5 -0.6 -1.0
Worrier / anxious feelings 1.8 3.4 7.0 1.6 -1.4 1.3 -2.6 -2.1 -1.4 -2.5 -2.1 0.9 -1.5 -2.0 -1.4 -1.8 -2.1 -1.9 -2.0
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.4 3.8 -1.1 1.7 1.1 0.7 1.2 1.7 0.8 1.2 -2.0 1.4 0.6 1.6 1.0 0.3 0.3 0.1
Falls in the last year 0.2 0.3 1.3 -0.8 0.5 1.1 -0.1 -0.1 0.5 -0.1 0.2 -0.8 0.7 0.2 0.5 -0.1 -0.2 -0.3 -0.2
Hair/balding pattern: Pattern 3 0.7 1.1 2.3 0.9 -1.3 -0.4 -1.0 -1.0 -1.3 -1.1 -1.4 1.5 -1.0 -1.0 -1.3 -0.9 -0.6 -0.3 -0.5
Number of live births 0.4 0.6 2.6 0.8 -0.8 0.7 0.3 -0.8 -0.8 -0.1 0.3 0.8 -1.0 0.3 -0.8 -0.1 1.6 1.0 0.2
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 3.2 1.4 -1.1 -0.1 -1.4 -1.1 -1.1 -1.6 -1.4 1.2 -1.2 -1.8 -1.1 -0.4 -0.5 -0.4 -1.0
Pulse rate 0.4 0.8 2.5 0.0 1.0 -0.3 0.0 1.3 1.1 0.2 -0.4 -0.7 0.5 -0.1 0.9 -0.6 -1.6 -1.4 -1.2
Happiness 0.8 1.0 5.7 0.8 0.1 -0.1 -1.1 -0.2 0.2 -0.8 -1.2 -0.2 -0.5 -0.9 0.2 -0.8 -2.4 -1.4 -1.6
Noisy workplace 2.2 2.7 5.9 0.5 -1.1 -0.3 -2.3 -1.3 -1.1 -2.2 -1.9 0.8 -1.0 -1.8 -1.1 -1.9 -2.4 -2.4 -2.1
Qualifications: A levels/AS levels or equivalent 0.5 1.0 2.4 -0.1 -0.9 -0.7 -1.1 -0.7 -0.8 -1.0 -1.4 0.9 -0.3 -1.6 -0.8 -0.8 -1.3 -1.4 -1.4
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 1.5 0.1 0.3 -0.5 -0.7 0.3 0.4 -0.5 -0.3 -0.5 -0.1 -0.2 0.3 0.1 -1.2 -0.4 -0.4
Mouth/teeth dental problems: Dentures 0.1 0.2 0.5 0.3 0.6 -0.0 0.5 0.7 0.6 0.2 0.4 -0.7 -0.0 0.4 0.7 -0.0 -0.3 -0.1 0.5
Asthma 0.5 1.0 3.3 0.9 -0.3 1.6 1.4 -0.3 -0.3 0.5 1.0 0.3 -0.4 1.7 -0.4 -0.3 1.8 1.1 1.5
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.9 0.5 0.2 0.9 0.4 0.0 0.2 0.4 0.5 -0.2 -0.1 0.8 0.2 0.3 0.3 0.9 0.9
Medication: Cholesterol lowering 0.5 0.8 1.9 0.3 -1.1 -0.8 -1.1 -1.4 -1.1 -1.1 -0.9 0.7 -0.7 -1.0 -1.1 -0.6 -0.2 -0.4 -0.6
Depression (self-reported) 1.0 1.2 2.5 -0.8 1.5 1.5 1.1 1.3 1.6 0.7 0.8 -1.5 1.2 1.0 1.6 0.1 -0.3 -0.5 -0.1
Medication: Lansoprazole 0.6 0.6 2.0 -0.2 0.5 -0.6 0.7 0.5 0.4 1.1 1.1 -0.4 0.1 1.3 0.5 0.2 1.4 1.1 1.0
Prospective memory result 0.2 0.2 1.0 -0.3 0.8 -0.6 -0.0 0.3 0.7 0.2 0.4 -1.0 0.6 0.2 0.6 -0.3 -0.3 -0.4 0.4
Lung cancer (father) 0.1 0.1 0.6 0.3 -0.1 -0.8 -0.1 0.1 -0.1 -0.1 0.1 0.2 -0.2 0.5 -0.1 0.8 0.2 0.6 0.0
Illnesses of mother 2.2 2.7 5.2 1.2 -2.2 0.5 -1.6 -2.1 -2.2 -1.7 -1.9 2.3 -1.6 -1.8 -2.2 -1.1 -0.9 -0.5 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 3.3 1.3 -1.0 -0.1 -1.5 -1.1 -1.0 -1.5 -1.3 1.1 -1.0 -1.8 -1.0 -0.3 -0.4 -0.3 -1.1
Pulse wave Arterial Stiffness index 1.2 1.4 2.7 1.1 -1.2 0.0 -1.2 -0.6 -1.2 -1.5 -1.6 1.4 -1.1 -1.6 -1.1 -0.9 -1.2 -1.1 -1.3
Impedance of arm (left) 0.1 0.6 1.7 -0.7 0.5 -1.3 0.5 0.9 0.4 1.3 0.7 -0.1 0.8 0.6 0.4 0.8 0.3 0.7 0.7
Arm fat mass (right) 1.0 4.2 6.4 -1.4 2.5 0.5 2.3 2.4 2.4 2.4 2.4 -2.5 1.9 2.2 2.5 1.4 1.4 1.3 1.9
Trunk predicted mass 0.3 1.6 3.6 1.9 -0.4 0.8 -1.6 -1.3 -0.4 -1.8 -1.3 -0.1 -1.4 -1.6 -0.4 -1.2 -0.8 -1.6 -1.8
Standing height 0.4 3.7 7.1 2.6 -1.5 0.3 -2.6 -2.1 -1.5 -2.5 -2.3 1.1 -2.0 -2.7 -1.5 -1.2 -1.1 -1.8 -2.3
Length of working week for main job 0.2 0.2 0.6 -0.6 0.5 0.8 0.3 0.2 0.6 0.4 0.3 -0.6 0.6 0.4 0.4 0.3 0.2 -0.0 -0.1
Exposure to tobacco smoke at home 0.2 0.2 0.5 -0.1 0.2 0.4 0.6 0.7 0.2 0.7 0.5 -0.0 0.3 0.5 0.2 -0.0 0.5 0.3 0.4
Breastfed as a baby 1.4 1.8 3.7 -1.9 1.9 -1.2 0.5 1.8 1.8 0.5 0.3 -1.7 1.7 -0.4 1.9 0.6 -1.2 -1.1 -0.6
Tense / ‘highly strung’ 0.3 0.5 2.0 0.2 0.8 1.4 -0.6 0.1 0.8 -0.4 -0.0 -1.2 0.3 0.1 0.7 -0.5 -0.6 -0.8 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.3 11.2 -0.4 1.2 3.3 0.8 0.4 1.1 0.7 0.9 -1.5 0.7 0.9 1.1 -0.2 0.2 -0.3 0.4
Hair/balding pattern: Pattern 4 0.3 0.8 1.6 -1.1 1.1 0.9 0.6 0.9 1.2 0.3 0.8 -1.3 1.2 1.2 1.1 0.7 0.4 0.3 0.5
Birth weight of first child 1.6 2.9 5.5 -1.2 2.0 -0.2 1.4 1.8 2.0 1.8 1.9 -2.2 1.2 1.5 2.0 2.3 1.3 1.7 1.4
Peak expiratory flow (PEF) 0.4 0.8 2.4 0.9 -1.0 0.7 0.0 -1.0 -1.0 -0.4 -0.0 1.1 -0.8 -0.5 -1.1 0.8 1.4 1.6 0.9
Pulse wave reflection index 0.4 0.5 1.4 -0.1 -0.5 1.2 1.0 -0.2 -0.5 0.5 0.5 0.6 -0.2 0.5 -0.4 0.3 1.2 1.0 1.1
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.4 0.7 -0.3 0.7 -0.3 -0.5 -0.2 -0.3 -0.5 0.5 -0.3 -0.2 -0.2 -0.1 -0.1 -0.2 -0.5
Loud music exposure frequency 0.6 0.7 1.9 -1.4 0.6 1.1 0.4 0.4 0.7 0.3 0.6 -0.7 1.3 0.5 0.6 1.3 -0.1 0.5 1.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.1 -0.7 -0.9 1.1 -0.3 -0.9 -0.9 0.1 -0.3 1.0 0.1 -0.7 -0.8 0.5 0.2 0.8 0.9
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 2.0 1.2 -1.3 1.3 -0.6 -1.4 -1.3 -0.3 -0.3 1.3 -1.1 -0.6 -1.2 0.1 0.6 0.8 0.5
Blood clot in the leg (DVT) 1.9 2.4 4.4 -1.8 1.8 -0.1 1.7 1.2 1.9 1.3 1.8 -2.1 1.8 2.0 1.8 1.3 0.6 0.9 1.4
Medication: Paracetamol 0.7 1.2 2.0 0.9 -1.1 0.7 -1.4 -1.2 -1.1 -1.2 -1.4 1.0 -0.8 -1.2 -1.1 -0.7 -1.3 -1.1 -1.0
Headache pain in last month 0.1 0.2 0.7 -0.5 0.6 0.8 -0.1 0.5 0.6 0.0 0.2 -0.7 0.7 0.3 0.5 -0.1 -0.3 -0.5 -0.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 1.3 1.1 -0.3 0.7 0.4 0.2 -0.3 -0.2 -0.1 0.7 -0.7 -0.0 -0.3 -0.0 -0.1 0.3 0.0
Glaucoma (self-reported) 0.5 0.6 1.1 -0.9 1.0 -0.2 0.7 0.9 1.0 0.9 0.3 -0.8 0.8 0.5 1.0 0.2 -0.4 -0.7 -0.8
Gout (self-reported) 0.5 0.7 6.3 0.8 -0.5 2.5 0.3 -0.8 -0.5 0.0 0.2 0.3 -0.7 0.2 -0.5 0.2 1.4 0.8 0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.8 -0.8 -0.0 0.2 -0.1 -0.2 -0.1 -0.3 -0.6 -0.0 0.4 -0.4 -0.1 -1.1 -0.9 -1.3 -1.1
Medication: Amlodipine 0.4 0.5 4.4 -0.4 0.5 -2.1 -1.1 -0.2 0.4 0.3 -0.0 -0.8 0.4 -0.1 0.5 -0.6 -0.5 -0.9 -0.4
Medication: Ventolin 100micrograms inhaler 1.6 2.0 6.0 1.1 -1.0 2.4 1.9 -0.6 -1.0 0.6 0.9 1.3 -1.0 0.7 -1.1 0.4 2.2 2.3 1.9
Birth weight 0.3 0.6 1.2 -0.3 1.0 -0.7 0.6 0.7 1.1 1.1 0.8 -1.1 0.4 0.9 0.9 0.8 1.0 0.5 0.3
Chronic bronchitis/emphysema (mother) 1.5 1.8 3.0 -0.7 1.6 -1.1 1.5 1.3 1.6 1.0 1.6 -1.6 1.1 1.4 1.7 1.7 1.0 1.0 0.8
High blood pressure (siblings) 0.3 0.4 1.0 -1.0 0.7 0.0 0.3 0.7 0.6 0.3 0.2 -0.7 1.0 0.7 0.8 -0.1 -0.5 -0.7 -0.3
Forced vital capacity (FVC), Best measure 0.1 0.3 1.0 1.0 -0.1 0.5 -0.4 -0.2 -0.1 -0.6 -0.3 0.2 -0.6 -0.9 -0.1 0.5 0.6 0.4 -0.6
Body fat percentage 1.5 6.0 9.7 -2.1 2.7 0.4 2.8 2.9 2.6 3.1 2.9 -2.7 2.5 2.8 2.8 1.8 1.7 1.7 2.3
Leg fat percentage (right) 1.1 4.0 7.1 -1.5 2.0 0.9 2.4 2.0 2.0 2.5 2.5 -2.0 1.8 2.7 2.1 1.2 1.6 1.6 2.4
Arm fat-free mass (right) 0.1 0.5 1.3 1.0 0.0 1.1 -0.8 -0.8 -0.0 -1.1 -0.5 -0.5 -0.7 -1.0 0.0 -0.3 0.1 -0.7 -0.9
Exposure to tobacco smoke outside home 0.4 0.5 3.7 0.7 -0.2 1.9 -0.4 -0.4 -0.1 -0.2 -0.5 0.1 -0.4 -0.4 -0.2 -1.2 -0.7 -0.9 -0.5
Comparative body size at age 10 0.4 1.2 3.2 -1.1 1.4 -0.4 0.1 1.0 1.5 0.8 1.0 -1.8 1.7 1.4 1.4 0.5 0.1 -0.4 -0.2
Number of full brothers 0.5 0.6 1.3 -0.9 1.1 -1.1 0.4 1.0 1.0 0.7 0.6 -1.1 0.8 0.5 1.1 0.7 -0.2 0.0 0.2
Worry too long after embarrassment 0.2 0.4 1.8 0.0 0.5 1.3 -0.9 -0.0 0.4 -0.5 -0.1 -0.9 0.2 0.4 0.5 -0.4 -0.9 -0.7 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 4.8 -0.8 1.9 0.8 0.1 1.3 1.8 0.4 0.8 -2.2 1.2 0.8 1.9 -0.1 -1.1 -1.0 -0.2
Wheeze or whistling in the chest in last year 0.5 1.0 2.2 -1.0 1.4 -0.8 0.2 1.0 1.4 0.3 0.8 -1.5 1.4 1.3 1.4 0.6 -0.1 -0.1 0.2
Number of children fathered 0.5 0.6 1.4 -0.5 1.2 0.1 0.5 1.1 1.2 0.7 0.5 -1.2 0.8 0.1 1.1 0.6 -0.3 0.2 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 2.3 0.4 -0.3 0.8 -1.4 -0.5 -0.2 -0.6 -1.0 0.1 -0.2 -0.9 -0.3 -0.8 -1.5 -1.4 -0.8
Age at first live birth 0.7 1.3 2.6 0.7 -1.1 -1.2 -1.1 -1.0 -1.2 -1.3 -1.3 1.0 -1.1 -1.6 -1.1 -1.2 -0.9 -1.1 -1.2
Pulse wave peak to peak time 1.1 1.3 2.3 -1.1 1.2 0.2 1.1 0.6 1.1 1.4 1.5 -1.4 1.1 1.5 1.1 0.9 1.1 0.9 1.1
Health satisfaction 0.6 0.8 2.2 1.4 -0.8 1.5 -0.7 -1.0 -0.8 -0.6 -0.9 0.6 -1.0 -0.4 -0.9 -1.2 -0.9 -0.7 -0.3
Shortness of breath walking on level ground 0.6 0.7 1.3 -1.0 1.1 -0.8 0.2 1.0 1.1 0.7 0.3 -1.0 1.1 0.8 1.0 -0.2 -0.5 -0.9 -0.5
Qualifications: College or University degree 0.3 1.0 2.1 -1.4 1.1 -1.4 -0.4 1.3 1.1 -0.4 -0.2 -1.2 1.2 -0.3 1.1 0.4 -1.0 -1.3 -1.0
Eye problems/disorders: None of the above 0.5 0.6 1.6 0.4 -0.8 0.2 -0.9 -1.0 -0.8 -1.3 -0.9 0.5 -0.5 -1.1 -0.7 0.1 -1.3 -0.6 -0.3
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.4 1.2 -1.2 0.8 -0.4 -1.5 -1.2 -0.6 -0.2 1.0 -1.3 -0.1 -1.0 0.0 0.7 0.6 0.3
Emphysema/chronic bronchitis 0.3 0.3 1.5 0.5 0.3 0.2 0.4 0.2 0.3 0.0 -0.1 -0.3 -0.1 0.1 0.3 -1.1 -0.7 -1.2 -1.0
Medication for pain relief, constipation, heartburn 0.1 0.2 2.4 -0.5 -0.2 -1.6 -0.2 -0.1 -0.3 0.0 -0.0 0.3 0.2 -0.2 -0.2 0.1 0.1 -0.1 0.1
Neck or shoulder pain in last month 0.5 0.8 7.8 0.0 0.3 2.8 0.6 0.3 0.4 0.7 0.6 -0.1 0.2 1.3 0.3 0.4 0.8 0.4 0.3
Medication: Blood pressure 0.3 0.5 1.4 -1.2 0.6 -0.8 0.0 0.2 0.6 0.8 0.8 -0.9 0.9 0.7 0.6 0.5 0.9 0.5 0.6
Angina (self-reported) 1.3 1.7 2.8 -1.5 1.4 -0.6 1.0 1.4 1.5 1.5 1.3 -1.3 1.6 1.5 1.5 1.7 0.7 0.8 1.0
Migraine (self-reported) 0.2 0.2 1.1 0.8 -0.2 0.7 0.0 0.0 -0.1 -0.1 -0.2 0.3 -0.4 0.3 -0.2 -1.1 0.0 -0.6 -0.7
Medication: Ibuprofen 0.7 0.8 2.0 0.1 0.7 1.2 1.2 0.5 0.8 0.8 1.0 -0.7 0.3 1.4 0.7 0.5 0.6 1.2 1.3
Medication: Allopurinol 0.6 0.8 3.6 0.3 0.4 1.9 0.7 -0.0 0.4 1.0 1.0 -0.7 -0.0 1.0 0.5 0.5 1.6 1.0 0.7
Medication: Omeprazole 0.4 0.5 2.7 0.4 -0.2 0.7 0.8 -0.3 -0.2 0.6 0.9 -0.0 -0.5 0.7 -0.2 0.2 1.6 1.1 0.9
Medication: Seretide 50 evohaler 0.8 1.0 2.5 -0.7 0.9 0.9 1.2 0.9 0.9 0.9 1.3 -1.0 0.9 1.1 0.7 0.9 0.7 0.8 1.6
Mean time to correctly identify matches 0.8 1.5 2.5 0.8 -1.5 0.5 -1.0 -1.1 -1.5 -1.4 -1.4 1.6 -1.0 -1.1 -1.5 -1.6 -1.2 -1.1 -0.7
Heart disease (mother) 1.1 1.4 2.8 -1.1 1.4 -0.4 1.7 1.6 1.3 1.4 1.5 -1.1 1.1 1.3 1.4 0.3 1.0 0.5 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 4.7 -1.0 0.2 -2.2 -0.3 0.3 0.2 0.1 -0.1 -0.2 0.8 -0.6 0.1 0.6 -0.1 -0.0 -0.3
Whole body fat mass 0.8 3.3 5.1 -1.1 2.1 0.6 2.0 2.0 2.1 2.3 2.2 -2.2 1.6 2.0 2.2 1.2 1.4 1.2 1.8
Leg fat mass (right) 0.7 2.6 4.1 -1.0 1.9 0.8 1.9 1.6 1.8 1.9 2.0 -2.0 1.4 2.0 1.9 0.9 1.2 1.0 1.7
Arm predicted mass (right) 0.1 0.4 1.7 1.0 0.2 1.3 -0.4 -0.6 0.2 -0.8 -0.2 -0.7 -0.6 -0.5 0.3 -0.3 0.3 -0.6 -0.7
Pulse rate, automated reading 0.3 1.0 2.5 -0.6 1.4 0.5 1.5 1.6 1.4 1.0 1.0 -1.2 0.8 1.0 1.4 0.2 0.1 0.2 0.3
Alcohol intake frequency. 0.3 0.6 1.8 0.5 -0.8 -0.8 -0.7 -0.8 -0.8 -1.0 -0.8 0.8 -0.5 -1.4 -0.7 -1.0 -0.8 -0.8 -0.3
Comparative height size at age 10 0.3 1.5 4.5 2.1 -1.1 0.1 -1.4 -1.6 -1.1 -1.6 -1.1 0.7 -1.6 -1.1 -1.1 -1.4 0.1 -1.0 -1.0
Number of full sisters 0.1 0.1 0.7 0.2 -0.3 0.9 0.4 -0.2 -0.2 -0.1 -0.1 0.4 -0.1 0.1 -0.2 -0.2 -0.1 0.1 0.3
Suffer from ‘nerves’ 0.8 1.2 4.6 1.2 -0.6 2.1 -1.2 -0.7 -0.5 -1.5 -1.1 0.2 -1.1 -1.0 -0.5 -1.0 -1.3 -1.1 -0.9
Overall health rating 0.3 0.6 4.8 -0.7 0.5 2.2 0.5 0.2 0.5 0.7 0.6 -0.7 0.6 0.8 0.4 0.2 0.3 0.2 0.4
Chest pain or discomfort 0.6 0.9 1.9 -1.3 1.0 1.1 1.1 0.8 1.1 0.8 0.8 -0.9 1.3 1.4 1.1 0.4 0.7 0.0 -0.1
Had major operations 0.5 0.6 2.7 0.8 -0.7 0.8 -0.1 -0.7 -0.7 -0.5 -0.5 0.7 -1.0 -0.4 -0.7 -1.6 -0.1 -0.8 -1.0
Age at last live birth 1.7 2.5 4.3 1.6 -1.6 -0.5 -1.7 -1.5 -1.6 -1.6 -1.7 1.4 -1.7 -1.9 -1.6 -2.1 -1.0 -1.6 -1.8
Family relationship satisfaction 0.5 0.6 2.4 0.9 0.1 -0.3 -0.9 -0.2 0.1 -0.4 -0.6 -0.2 -0.7 -0.5 0.2 -0.9 -1.2 -1.1 -1.6
Leg pain on walking 1.2 1.5 4.6 -0.7 1.8 0.4 0.4 1.0 1.9 0.8 1.0 -2.1 1.3 1.4 1.9 0.6 -0.5 -0.5 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.6 -0.9 0.6 1.3 0.9 0.8 0.6 0.5 1.0 -0.5 0.9 0.7 0.6 1.6 0.4 1.4 1.6
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.5 1.2 -0.9 0.8 0.8 -0.9 -0.9 0.2 0.0 1.2 -1.1 0.6 -1.0 -0.2 1.2 1.0 0.6
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 9.7 -0.6 0.4 -3.1 -1.1 0.7 0.4 -0.7 -1.0 -0.4 0.4 -0.9 0.5 -0.7 -2.1 -1.9 -1.7
Medication: Aspirin 0.4 0.6 2.6 0.4 -0.8 1.6 0.4 -0.8 -0.8 -0.0 -0.1 0.7 -0.9 -0.2 -0.8 -1.1 1.0 -0.1 -0.2
Supplements: Vitamin C 0.9 1.1 3.2 1.4 -1.3 1.8 -0.0 -1.2 -1.2 -0.8 -0.7 1.5 -1.3 -0.4 -1.3 -0.7 -0.1 0.0 0.3
Knee pain experienced in last month 0.3 0.4 1.5 0.1 -0.1 1.1 -1.0 -0.3 -0.1 -0.8 -0.6 -0.1 -0.1 -0.3 -0.1 -0.6 -0.5 -1.0 -1.2
Hypertension (Self-reported) 0.2 0.4 1.6 -0.4 0.4 0.1 0.5 -0.2 0.3 1.2 1.0 -0.7 0.3 0.7 0.5 0.0 1.3 0.6 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.7 0.6 -0.4 -0.1 -0.6 -0.2 -0.4 -0.7 -0.6 0.4 -0.6 -0.2 -0.4 -0.8 -0.3 -0.6 -0.7
Illnesses of father: Heart disease 1.4 1.9 4.6 2.1 -1.3 -0.6 -0.9 -1.0 -1.3 -1.3 -1.3 1.3 -2.0 -1.2 -1.3 -1.8 -1.0 -1.3 -1.4
Illnesses of siblings: Diabetes 0.5 0.6 1.5 -0.8 0.4 1.2 1.0 0.6 0.3 0.9 0.8 -0.3 0.5 0.3 0.3 1.1 0.4 1.1 1.2
Smoking status: Previous 0.3 0.5 2.8 -0.2 0.7 1.7 0.0 0.2 0.7 -0.2 -0.1 -0.9 0.4 0.2 0.7 -0.2 -1.3 -0.8 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.8 1.7 -1.4 1.0 -1.0 -1.6 -1.4 -1.5 -1.0 1.1 -1.3 -1.4 -1.4 -0.4 0.5 -0.2 -0.9
Whole body fat-free mass 0.1 0.7 1.6 1.2 0.2 0.6 -1.0 -0.6 0.2 -1.2 -0.6 -0.7 -0.7 -1.0 0.2 -0.7 -0.4 -1.2 -1.2
Leg fat-free mass (right) 0.1 0.3 1.6 0.4 0.9 0.4 0.1 0.3 0.9 -0.2 0.4 -1.3 0.0 -0.2 1.0 0.2 0.3 -0.4 -0.4
Arm fat percentage (left) 1.7 6.9 11.0 -2.3 3.0 0.2 3.0 3.1 2.9 3.3 3.1 -2.9 2.6 2.8 3.0 1.9 1.8 1.8 2.5
Average weekly red wine intake 0.5 0.8 2.5 -0.1 0.4 0.5 0.7 0.6 0.4 0.6 1.0 -0.3 0.3 1.0 0.3 1.6 1.3 1.6 1.3
Handedness (chirality/laterality): Left-handed 0.4 0.4 1.5 -0.9 0.0 -0.4 -0.7 0.1 0.0 -0.1 -0.7 0.1 0.6 -0.9 -0.1 0.0 -1.2 -0.9 -1.2
Mood swings 1.8 3.3 10.1 2.2 -1.7 3.2 -1.5 -2.7 -1.7 -1.7 -1.3 1.2 -2.1 -1.0 -1.7 -2.5 -0.4 -1.1 -0.7
Loneliness, isolation 0.5 0.7 3.9 1.0 0.5 2.0 -0.5 0.2 0.5 -0.6 -0.2 -0.6 -0.5 0.1 0.5 -1.0 -0.4 -1.0 -1.3
Long-standing illness, disability or infirmity 0.7 1.1 6.9 -0.2 0.7 2.6 1.2 0.4 0.6 1.2 1.2 -0.6 0.4 1.0 0.6 0.4 1.3 0.7 0.6
Ever had bowel cancer screening 1.0 1.2 3.4 -1.7 1.5 1.1 -0.0 1.2 1.4 0.7 0.5 -1.8 1.3 0.5 1.4 -0.1 -0.1 -0.9 -0.7
Diabetes diagnosed by doctor 0.1 0.2 0.9 0.1 -0.5 0.0 -0.3 -0.4 -0.6 -0.5 -0.4 0.5 -0.3 -1.0 -0.5 -0.4 -0.2 0.2 0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.0 4.0 1.7 -1.7 0.7 -1.4 -2.0 -1.6 -0.8 -1.3 1.5 -1.7 -0.9 -1.7 -2.0 -0.6 -1.1 -1.0
Friendships satisfaction 0.3 0.4 2.4 1.1 -0.3 0.6 -0.3 -0.3 -0.4 0.1 -0.3 0.3 -1.0 -0.1 -0.2 -1.5 -0.4 -0.6 -0.5
Qualifications: nursing, teaching 0.2 0.3 1.1 -0.4 0.8 -0.2 0.3 1.1 0.8 0.6 0.1 -0.5 0.7 0.3 0.7 0.1 -0.6 -0.5 -0.3
Commuting to job workplace: Walk 0.5 0.6 1.4 0.0 -0.9 -0.1 -1.2 -1.0 -1.0 -0.9 -0.7 0.7 -0.5 -0.9 -0.7 -0.6 -0.3 -0.4 -1.1
Eye problems/disorders: Cataract 0.4 0.5 1.6 0.1 0.7 0.1 1.1 1.0 0.7 1.2 0.9 -0.5 0.1 0.8 0.6 -0.2 1.0 0.4 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.9 -0.7 1.3 1.4 0.9 1.0 1.2 0.7 0.6 -1.2 0.9 0.5 1.3 0.3 -0.3 -0.3 -0.4
Medication for cholesterol 1.3 2.0 3.4 1.4 -1.8 1.1 -1.2 -1.7 -1.8 -1.7 -1.4 1.8 -1.5 -1.2 -1.7 -1.4 -0.5 -0.7 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.6 3.8 -0.3 1.7 1.0 1.2 1.9 1.7 1.4 1.3 -1.3 1.1 1.2 1.6 1.2 0.5 0.5 0.6
Back pain experienced in last month 0.4 0.6 3.2 -0.4 0.6 1.8 0.6 0.1 0.6 0.9 0.9 -0.8 0.4 1.0 0.6 0.0 0.8 0.2 0.4
Mineral and other dietary supplements 1.0 1.3 8.2 -1.6 1.1 -2.9 -0.2 0.9 1.0 0.5 0.7 -1.3 1.4 0.2 1.2 0.9 -0.2 0.1 0.3
Breast cancer (self-reported) 0.3 0.4 1.6 0.8 -0.6 0.5 0.1 -0.4 -0.6 -0.1 0.0 0.5 -0.9 -0.2 -0.5 0.1 0.6 0.9 1.3
Asthma (self-reported) 0.5 1.0 3.2 0.9 -0.2 1.6 1.4 -0.2 -0.1 0.6 1.1 0.1 -0.3 1.8 -0.1 -0.4 1.7 0.9 1.4
Osteoporosis (self-reported) 0.3 0.3 2.7 0.5 -0.3 1.6 0.8 0.4 -0.1 0.2 0.0 0.5 -0.1 0.4 -0.3 -0.6 0.6 0.1 0.5
Osteoarthritis (self-reported) 1.0 1.3 3.3 -1.1 1.5 0.3 1.0 1.8 1.5 1.2 1.0 -1.3 1.2 1.1 1.5 1.0 -0.1 0.1 0.4
Medication: Aspirin 0.3 0.4 2.7 0.2 -0.4 1.6 0.4 -0.4 -0.5 0.1 0.0 0.4 -0.6 -0.0 -0.4 -1.0 0.8 -0.2 -0.4
Medication: Gliclazide 0.4 0.5 1.1 1.0 -0.6 -0.5 -0.3 -0.6 -0.6 -0.7 -0.7 0.6 -0.8 -0.6 -0.7 -1.1 -0.8 -0.8 -0.7
Illnesses of father: None of the above (group 1) 0.8 0.9 2.0 -1.4 1.3 -0.8 0.2 1.3 1.4 0.5 0.5 -1.4 1.4 0.4 1.4 0.4 -0.5 -0.3 -0.3
Smoking status: Current 0.4 0.6 2.3 -0.1 -0.4 1.3 0.6 -0.7 -0.4 0.2 0.5 0.3 -0.2 0.1 -0.3 0.6 1.5 1.4 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.8 0.4 -0.6 -0.8 -0.6 0.0 -0.5 -0.5 -0.8 0.9 -0.4 -0.9 -0.6 -0.6 -0.6 -0.2 -0.4
Whole body water mass 0.1 0.5 1.3 1.1 0.3 0.7 -0.8 -0.5 0.3 -1.0 -0.5 -0.7 -0.6 -0.9 0.3 -0.5 -0.3 -1.0 -1.1
Leg predicted mass (right) 0.1 0.3 1.6 0.4 1.0 0.4 0.2 0.3 0.9 -0.1 0.4 -1.3 0.0 -0.2 1.0 0.2 0.3 -0.4 -0.3
Arm fat mass (left) 1.0 4.2 6.3 -1.6 2.4 0.6 2.3 2.3 2.4 2.5 2.4 -2.5 1.9 2.1 2.5 1.4 1.5 1.3 1.8
Number of self-reported non-cancer illnesses 1.7 2.9 9.1 -1.8 1.1 3.0 2.3 0.7 1.1 1.7 1.9 -1.2 1.5 2.4 1.1 0.5 2.4 1.3 1.3
Average weekly champagne plus white wine intake 0.5 0.7 1.3 0.9 -0.9 -1.0 -1.0 -0.7 -0.9 -1.1 -0.8 0.9 -0.8 -0.6 -1.0 -0.4 -0.2 -0.2 -1.1
Miserableness 0.5 0.9 2.9 0.2 1.3 1.7 0.2 0.6 1.3 0.9 0.8 -1.5 0.4 0.9 1.3 -0.8 -0.6 -0.8 -0.1
Guilty feelings 1.9 2.8 15.3 2.3 -1.6 3.9 -1.1 -1.9 -1.5 -1.4 -1.1 1.5 -1.9 -1.3 -1.6 -1.0 -0.6 -0.3 -0.4
Wears glasses or contact lenses 1.0 1.1 4.1 -0.8 1.1 0.3 -0.2 0.6 1.2 0.6 -0.1 -1.6 0.7 0.6 1.0 -1.6 -1.0 -2.0 -1.2
Ever taken oral contraceptive pill 0.1 0.1 0.6 -0.2 -0.1 0.8 -0.1 0.4 -0.1 -0.2 -0.2 0.4 0.3 -0.4 -0.1 0.6 -0.4 0.4 0.4
Hearing aid user 2.8 3.1 6.4 -2.3 2.2 0.1 1.5 2.5 2.2 2.2 1.5 -1.7 2.1 1.3 2.2 2.0 0.4 0.9 0.9
Mother’s age at death 0.5 0.6 1.5 0.7 -1.1 1.0 -0.4 -0.7 -1.1 -0.3 -0.8 1.2 -0.8 -0.7 -1.0 -0.7 -0.2 -0.4 -0.7
Financial situation satisfaction 1.1 1.4 3.3 0.0 1.2 1.8 1.7 1.0 1.2 1.7 1.4 -1.1 0.4 1.0 1.2 0.9 0.8 1.1 0.9
Tinnitus: Yes, now most or all of the time 0.2 0.2 1.0 0.2 0.2 -0.0 0.5 0.7 0.2 0.0 0.3 0.0 0.1 0.3 0.2 0.8 0.3 1.0 0.6
Commuting to job workplace: Public transport 3.7 4.4 16.9 -0.5 -0.1 -2.4 -2.5 0.2 -0.1 -2.2 -2.6 0.1 0.4 -2.7 -0.1 -1.1 -4.1 -3.3 -3.1
Eye problems/disorders: Glaucoma 0.3 0.3 1.4 -0.5 0.4 1.2 1.1 0.5 0.4 0.8 0.3 -0.1 0.4 0.5 0.4 -0.2 0.1 -0.1 -0.0
Medication: Blood pressure 0.6 1.2 2.6 -1.1 1.4 -0.6 0.9 1.0 1.3 1.4 1.2 -1.6 1.1 0.8 1.5 0.9 0.4 0.4 0.3
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.6 -0.6 0.6 0.4 -0.4 0.5 0.6 -0.1 -0.2 -0.8 0.5 -0.2 0.6 -0.6 -0.7 -0.8 -0.5
Supplements: Fish oil (including cod liver oil) 2.0 2.6 6.2 2.5 -2.1 1.5 -0.5 -2.0 -2.0 -1.0 -1.1 2.2 -2.3 -0.5 -2.2 -1.5 0.5 0.2 0.1
High cholesterol (Self-reported) 0.2 0.3 1.0 0.2 -0.3 -0.7 -0.6 -0.0 -0.3 -0.8 -0.8 0.3 -0.2 -0.8 -0.4 -0.3 -1.0 -0.5 -0.5
Medication: Bendroflumethiazide 1.5 2.2 10.1 0.4 -0.7 -3.2 -2.2 -0.9 -0.7 -1.1 -1.6 0.6 -0.6 -1.6 -0.7 -1.4 -1.9 -1.8 -1.4
Medication: Paracetamol 0.6 0.9 2.8 0.9 -0.7 0.3 -1.2 -0.6 -0.7 -1.4 -1.3 0.7 -0.5 -1.2 -0.6 -0.2 -1.7 -1.1 -0.9
Medication: Lisinopril 0.1 0.1 0.8 -0.3 0.1 -0.9 -0.0 -0.3 0.1 0.2 0.1 -0.1 0.3 0.2 0.1 0.2 -0.3 -0.1 -0.1
Medication: Atorvastatin 0.5 0.7 1.5 -1.0 0.6 0.6 1.0 0.5 0.6 0.7 1.0 -0.8 0.6 0.8 0.7 0.6 1.0 0.9 1.2
Illnesses of father: High blood pressure 1.0 1.3 3.6 -0.8 1.0 0.5 1.1 1.0 1.1 1.2 1.5 -1.3 1.0 1.9 1.1 0.6 1.3 0.7 1.3
Alcohol drinker status: Never 0.2 0.2 0.7 -0.6 0.6 0.3 0.5 0.7 0.5 -0.1 0.5 -0.5 0.7 0.1 0.4 0.4 0.2 0.3 0.8
Ever smoked 0.4 0.8 5.2 0.2 0.3 2.3 -0.5 -0.0 0.3 -1.0 -0.8 -0.3 -0.1 -0.5 0.3 -0.7 -1.4 -1.3 -0.7
Basal metabolic rate 0.1 0.3 1.0 0.9 0.6 0.7 -0.4 -0.2 0.5 -0.6 -0.1 -1.0 -0.3 -0.5 0.6 -0.3 -0.0 -0.7 -0.7
Leg fat percentage (left) 0.9 3.2 5.1 -1.5 1.8 0.7 2.2 1.8 1.7 2.2 2.2 -1.9 1.6 2.2 1.8 1.2 1.5 1.5 2.1
Arm fat-free mass (left) 0.1 0.3 1.3 0.7 0.4 1.2 -0.3 -0.4 0.4 -0.6 -0.1 -0.9 -0.3 -0.4 0.5 -0.2 0.1 -0.6 -0.7
Number of operations (self-reported) 0.5 0.8 8.0 -0.3 0.5 2.8 0.9 0.1 0.5 0.5 0.7 -0.6 0.3 0.9 0.5 -0.2 0.9 0.1 -0.1
Average weekly beer plus cider intake 0.7 1.0 2.5 1.6 -0.9 1.5 0.9 -0.5 -0.8 0.3 0.4 0.9 -1.5 0.2 -0.8 -0.8 1.0 1.0 1.3
Irritability 0.1 0.3 1.1 -0.0 0.6 1.0 -0.2 -0.0 0.6 -0.1 0.4 -1.0 0.4 0.2 0.6 0.5 -0.3 0.1 0.5
Risk taking 0.8 1.2 4.4 0.3 0.4 2.1 1.1 0.3 0.5 1.0 1.2 -0.4 0.2 1.3 0.4 0.8 1.5 1.5 1.8
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.2 0.5 -0.8 0.9 -0.2 -0.2 -0.9 -0.7 -0.5 1.1 -0.6 -0.8 -0.9 0.7 0.2 0.6 0.1
Fractured/broken bones in last 5 years 2.4 3.1 6.2 2.4 -1.7 0.3 -1.4 -1.9 -1.7 -1.9 -1.8 1.5 -2.1 -1.3 -1.8 -2.5 -0.6 -1.7 -2.0
Age started oral contraceptive pill 0.1 0.2 0.8 0.3 0.3 0.8 0.6 0.9 0.3 0.5 0.1 -0.1 -0.2 0.1 0.2 0.0 -0.0 0.2 0.3
Diastolic blood pressure, automated reading 0.1 0.3 1.3 0.5 0.3 1.0 1.1 0.5 0.3 0.8 0.5 -0.3 -0.3 0.3 0.2 -0.1 0.5 0.3 0.3
Ever depressed for a whole week 0.3 0.4 0.8 0.9 -0.7 0.6 -0.5 -0.8 -0.7 -0.5 -0.4 0.6 -0.9 -0.5 -0.8 -0.8 -0.0 -0.4 -0.4
Unable to work because of sickness or disability 2.2 2.9 4.8 -2.0 2.0 0.3 1.4 1.8 2.0 1.9 1.9 -2.1 2.1 2.2 1.9 1.4 1.1 0.7 0.8
Commuting to job workplace: Cycle 0.5 0.6 2.8 -0.3 0.6 -0.7 -0.5 1.4 0.6 -0.4 -0.7 -0.4 0.1 -1.1 0.5 0.4 -1.7 -0.9 -0.7
Myopia 1.7 2.5 7.7 -0.4 1.0 -2.8 -1.5 1.0 1.0 -0.7 -1.0 -1.4 0.7 -0.7 1.1 -1.2 -2.7 -2.7 -2.3
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.5 0.8 -0.8 -0.4 -1.0 -0.3 -0.7 -1.6 -1.3 0.9 -0.7 -1.0 -0.8 -0.1 -1.3 -0.6 -0.4
Cholesterol lowering medication 0.1 0.2 0.7 -0.4 0.6 -0.4 0.2 0.8 0.6 -0.1 -0.1 -0.5 0.3 0.1 0.5 -0.3 -0.7 -0.5 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 1.6 -0.5 0.9 -0.1 0.8 0.7 0.9 1.0 1.3 -1.1 0.5 1.1 0.9 0.6 1.2 0.8 0.8
Pain experienced in last month 0.4 0.6 7.6 -0.6 0.2 -2.8 0.3 0.3 0.2 0.4 0.2 -0.3 0.4 -0.0 0.2 0.2 0.2 0.4 0.7
Supplements: Calcium 0.9 1.0 2.5 -0.5 0.8 1.6 1.5 1.1 0.8 1.4 1.2 -0.5 0.5 1.2 0.8 0.6 1.2 0.8 0.7
Basal cell carcinoma (self-reported) 0.3 0.3 2.1 -0.7 -0.0 -0.5 -0.2 0.1 0.1 0.4 0.2 0.1 0.7 0.3 0.1 1.4 0.2 0.9 0.7
Heart attack/myocardial infarction (self-reported) 0.6 0.7 1.6 -0.9 0.9 -0.0 0.9 0.7 0.9 0.6 0.9 -0.8 0.8 1.1 1.0 1.3 0.7 0.5 0.9
Deep venous thrombosis (DVT) (self-reported) 2.4 3.1 5.2 -1.8 2.0 0.1 1.9 1.3 2.0 1.6 2.1 -2.2 2.0 2.3 2.0 1.6 1.0 1.4 1.8
Heart disease (siblings) 0.2 0.3 0.7 -0.8 0.6 -0.4 0.1 0.6 0.6 0.0 0.2 -0.7 0.7 0.4 0.7 0.6 -0.6 -0.2 0.1
Alcohol drinker status: Previous 0.1 0.2 0.8 -0.5 0.1 -0.5 -0.3 0.4 0.1 -0.3 -0.2 0.2 0.5 -0.5 0.2 0.9 -0.5 0.1 0.2
Pack years of smoking 0.2 0.3 0.8 -0.9 0.6 0.9 0.2 0.4 0.7 0.5 0.2 -0.8 0.7 0.2 0.6 0.3 -0.1 -0.5 -0.6
Impedance of whole body 0.0 0.2 0.7 -0.2 -0.5 -0.8 0.1 -0.0 -0.4 0.6 0.0 0.7 0.2 0.2 -0.5 0.6 0.1 0.6 0.6
Leg fat mass (left) 0.7 2.7 4.1 -1.1 1.9 0.9 1.9 1.6 1.8 1.9 2.0 -2.0 1.4 1.9 1.9 1.0 1.3 1.1 1.7
Arm predicted mass (left) 0.1 0.5 1.3 0.9 0.2 0.9 -0.7 -0.7 0.2 -1.0 -0.5 -0.7 -0.6 -0.8 0.2 -0.7 -0.3 -1.0 -1.1