Hub : Genes

OTOA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0290	0.01300	0.028	-0.002	0.004	-0.001	0.012	0.00019	0.66000	0.08900	0.46	0.01100
2	TCGA	Breast Invasive Carcinoma	0.0241	0.0114	0.00044	0.013	0.017	0.016	NA	0.014	0.00082	0.00014	0.00027	NA	0.00057
3	TCGA	Liver Hepatocellular Carcinoma	0.1150	0.0570	0.00360	0.010	0.029	0.002	NA	0.008	0.09900	0.01500	0.24000	NA	0.13000
4	TCGA	Lung Adenocarcinoma	0.0290	0.0154	0.00300	0.021	0.013	0.010	NA	0.011	0.00150	0.01100	0.02000	NA	0.01500

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.1	3.3	4.5	1.4	-2.0	-1.6	-2.1
Bipolar Disorder or Schizophrenia	2.0	4.9	6.9	1.9	-2.3	-2.6	-1.9
Depressed Affect (Nagel 2018)	1.2	2.4	4.2	0.6	-2.0	-1.6	-1.6
Depression (Nagel 2018)	3.1	4.7	5.5	1.8	-2.3	-2.3	-2.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	0.2	-0.9	-0.7	-0.5
Neuroticism (Nagel 2018)	0.8	2.0	3.8	1.1	-1.2	-1.1	-1.9
Schizophrenia (2018)	0.9	1.9	4.0	1.3	-1.2	-2.0	-0.6
Schizophrenia vs Biploar Disorder	1.5	2.0	3.1	-1.0	1.8	1.2	1.5
Worry (Nagel 2018)	0.7	1.5	3.2	1.4	-0.6	-0.7	-1.8
Alzheimer’s Disease (in mother)	0.3	0.3	1.1	0.3	1.1	-0.1	0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.6	-0.2	-0.8	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.1	0.2	0.3	-1.0	-0.1
Crohns Disease (2017)	0.5	1.2	2.8	0.3	-1.2	-1.7	-0.6
Irritable Bowel Disease (IBD)	0.6	1.5	3.3	-0.4	-1.6	-1.8	-0.3
Ulcerative Colitis (UC)	0.4	0.7	1.3	-0.6	-1.1	-1.1	-0.2
Major Depression (MDD)	6.1	7.4	12.9	1.0	-2.8	-3.6	-2.8
Reaction Time	0.4	0.7	1.3	1.1	-0.5	0.1	-1.1
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.0	1.4	-0.8	-0.2	-1.7
Breast Cancer	0.1	0.3	0.9	0.3	-0.1	-0.4	-1.0
Ovarian Cancer	0.6	0.8	1.8	-0.2	-1.3	-1.1	0.3
Prostate Cancer	0.0	0.1	0.1	-0.1	0.3	0.1	0.3
Age at First Birth	0.8	1.2	2.9	-0.7	0.8	0.7	1.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	0.8	0.1	0.6	-0.8
Coronary Artery Disease (CAD)	1.5	1.8	2.7	-1.1	1.6	1.0	1.5
Crohns Disease (2012)	0.2	0.2	0.8	0.1	-0.4	-0.9	0.3
Mean Putamen Volume	2.7	3.1	6.9	-1.4	1.9	-0.4	2.6
Fasting Glucose	3.3	3.9	5.4	2.3	-1.3	-2.3	-1.9
HbA1C	0.4	0.5	1.5	1.2	0.1	-0.5	-0.5
HDL Cholesterol	0.2	0.4	1.0	-0.7	0.1	-0.1	1.0
LDL Cholesterol	4.2	6.6	11.7	3.3	-1.7	-0.8	-3.4
Lupus	0.3	0.5	1.4	1.2	0.0	0.1	-0.8
Neuroticism (2016)	1.0	1.4	2.4	0.7	-1.6	-1.3	-1.0
Primary Biliary Cirrhosis	0.7	0.9	1.4	0.6	-1.2	-1.1	-0.9
Rheumatoid Arthritis	1.7	2.4	3.3	-1.8	1.4	0.9	1.8
Schizophrenia (2014)	0.9	1.9	4.2	0.8	-1.3	-2.0	-1.1
Triglycerides	0.8	1.4	3.3	0.6	-1.1	-0.7	-1.8
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.3	-0.3	0.1	0.0
Ulcerative Colitis	0.6	0.8	1.1	-1.0	-0.7	-0.9	1.0
Blood Eosinophil Count	0.1	0.5	0.6	0.8	-0.7	-0.3	-0.8
Blood Platelet Count	0.0	0.4	0.6	-0.6	-0.3	0.7	-0.8
Blood Red Count	0.2	1.6	3.5	-0.1	-1.9	-1.6	-0.6
Blood White Count	0.0	0.2	0.7	-0.4	-0.0	0.8	-0.0
Heel T-Score	1.7	13.9	19.1	-4.1	3.6	2.6	4.4
BMI	0.1	0.4	1.0	-0.2	0.4	-0.5	-1.0
Height	0.0	0.8	2.4	-0.7	-0.4	0.3	1.6
Waist Hip Ratio (WHR)	0.3	1.2	2.7	0.9	-1.1	-0.0	-1.6
Systolic Blood Pressure	0.7	3.6	6.8	-2.5	0.7	1.0	2.6
Smoking Status	0.1	0.2	0.5	0.4	-0.7	-0.1	-0.4
Allergy or Eczema	0.3	0.7	1.5	0.6	-1.2	-0.9	0.3
Cardiovascular Disease	0.6	2.0	4.1	-1.8	-0.1	-0.8	2.0
Hypothyroidism (self reported)	0.1	0.2	0.3	-0.5	0.5	0.4	0.5
Respiratory disease	0.7	1.6	4.0	1.4	0.1	0.7	-2.0
Type 2 Diabetes (T2D) (2018)	1.1	2.1	2.6	-1.6	1.4	1.5	1.3
Lung FEV1/FVC ratio	0.1	0.5	1.7	-0.3	0.0	-1.3	-0.1
Lung FVC	0.1	0.7	1.5	0.3	-1.1	-1.2	-0.2
Neuroticism	0.5	1.2	2.2	0.6	-1.1	-1.0	-1.5
Chronotype (morning person)	0.1	0.3	0.4	0.2	-0.7	0.7	0.4
Hair Pigment	0.0	0.5	1.2	0.5	-0.1	0.8	-1.1
Tanning	0.1	1.7	3.4	-1.4	0.9	0.7	1.9
Hand grip strength (left)	0.2	0.6	1.3	0.1	-1.1	-1.1	-0.3
Number of treatments/medications taken	0.3	0.5	0.8	-0.6	0.9	0.7	0.6
Average weekly spirits intake	0.6	0.8	1.9	1.4	-0.2	0.4	-1.0
Sensitivity / hurt feelings	0.6	1.1	1.4	1.0	-0.8	-1.2	-1.2
Frequency of depressed mood in last 2 weeks	1.7	2.4	5.5	0.1	-1.6	-2.4	-1.2
Hearing difficulty/problems: Yes	1.1	1.7	3.4	0.5	1.8	1.4	-1.0
Relative age of first facial hair	0.5	1.0	2.3	1.5	-0.1	0.0	-1.3
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	2.8	1.6	-1.7	-1.5	-1.5
Ever used hormone-replacement therapy (HRT)	2.0	2.6	3.5	1.5	-1.7	-1.3	-1.9
Ever had hysterectomy (womb removed)	0.9	1.0	1.4	-0.9	1.1	1.2	0.8
Systolic blood pressure, automated reading	1.3	3.8	5.9	-2.4	1.4	1.3	2.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.4	-0.5	-0.5	-0.2
Angina	0.6	0.8	1.4	-0.7	-0.5	-1.1	1.2
Medication for hormone replacement therapy	1.7	1.9	4.5	2.1	-1.2	-0.6	-1.1
Vitamin and mineral supplements	3.3	4.5	7.8	-2.0	1.9	1.6	2.8
Supplements: Zinc	2.8	3.1	4.9	1.7	-1.3	-1.7	-2.2
Medication: Co-codamol	0.1	0.1	0.1	0.3	-0.4	-0.1	0.1
Medication: Metformin	0.4	0.5	1.4	-1.2	0.7	0.4	0.2
Diabetes (father)	0.8	0.9	1.7	1.2	1.3	0.7	-0.0
Diabetes (mother)	1.6	2.1	4.9	-0.2	-1.8	-2.2	0.1
Severe depression (siblings)	5.0	5.6	9.9	1.9	-2.3	-1.9	-3.1
Pack years adult smoking proportion	0.3	0.4	0.9	-1.0	0.3	0.3	0.7
Impedance of leg (right)	0.1	0.6	0.9	1.0	0.0	0.9	-0.8
Leg fat-free mass (left)	0.1	0.4	0.9	-1.0	0.5	0.3	0.6
Trunk fat percentage	0.3	1.3	2.1	-1.4	1.4	1.1	0.2
Hand grip strength (right)	0.0	0.1	0.3	0.1	-0.5	-0.4	0.1
Townsend deprivation index at recruitment	3.0	4.2	8.5	-0.5	-2.7	-2.9	-0.9
Current tobacco smoking	0.5	0.9	2.2	0.6	-1.5	-0.8	-0.6
Average weekly fortified wine intake	1.1	1.3	2.9	0.4	-1.1	-1.7	-1.0
Maternal smoking around birth	0.3	0.5	0.8	-0.6	-0.5	-0.8	0.9
Fed-up feelings	0.3	0.5	0.7	-0.8	-0.8	-0.5	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	3.3	4.4	6.1	1.6	-2.3	-2.5	-1.8
Relative age voice broke	0.6	0.9	1.8	1.3	-0.1	-0.5	-1.3
Taking other prescription medications	0.4	0.6	1.3	0.1	0.7	1.2	-0.6
Age when periods started (menarche)	0.2	0.4	0.9	1.0	-0.6	-0.4	-0.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.9	0.5	-1.7	-1.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.2	8.8	-2.5	2.8	1.4	3.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.0	0.1	-0.1	-0.6
Qualifications: CSEs or equivalent	0.4	0.6	0.9	0.8	-0.5	-0.9	-0.7
Serious illness, injury or assault to yourself	0.2	0.3	0.7	0.8	-0.3	-0.4	-0.3
High blood pressure	0.9	2.5	5.8	-2.0	0.4	-0.1	2.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.0	0.4	-1.0	-0.6	0.1
Multivitamins +/- minerals	4.2	5.3	7.6	2.0	-2.5	-1.8	-2.8
Stomach or abdominal pain in last month	0.1	0.2	0.5	-0.3	0.2	0.2	-0.7
Supplements: Glucosamine	0.1	0.2	0.5	0.2	0.1	0.3	-0.7
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.7	1.6	-0.4	0.0	-0.9
Medication: Atenolol	0.4	0.5	1.0	-0.7	-0.1	-0.5	1.0
Medication: Levothyroxine sodium	0.2	0.3	0.5	0.6	-0.7	-0.4	-0.5
Sitting height	0.2	1.1	2.0	1.2	-1.1	-0.1	-1.4
Chronic bronchitis/emphysema (father)	0.4	0.4	0.6	0.7	0.8	0.7	-0.4
High blood pressure (mother)	0.5	0.6	1.0	-0.4	-1.0	-0.5	-1.0
Body mass index (BMI)	0.1	0.6	1.6	-1.3	0.8	0.4	0.0
Impedance of leg (left)	0.1	0.4	0.7	0.8	-0.1	0.7	-0.7
Leg predicted mass (left)	0.1	0.4	0.9	-1.0	0.4	0.2	0.6
Trunk fat mass	0.3	1.3	2.7	-1.6	1.2	0.9	0.4
Waist circumference	0.3	0.9	2.0	-1.4	0.9	0.9	0.0
Number of incorrect matches in round	0.8	1.4	3.0	-1.2	-0.9	-1.7	0.7
Past tobacco smoking	0.2	0.4	0.7	0.3	0.8	0.9	0.1
Alcohol usually taken with meals	0.6	1.0	2.9	-1.7	0.7	0.0	0.8
Nervous feelings	1.4	2.6	7.3	1.4	-0.8	-0.7	-2.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.8	1.3	-0.6	-1.0	-1.0
Hearing difficulty/problems with background noise	1.8	2.9	7.6	1.7	-0.7	-0.7	-2.8
Hair/balding pattern: Pattern 2	2.0	2.6	4.1	1.0	-1.9	-1.3	-2.0
Had menopause	0.8	0.9	1.6	-1.3	-1.0	-1.0	-0.1
Had other major operations	0.7	0.8	1.9	1.4	-0.2	0.6	-1.0
Forced vital capacity (FVC)	0.7	2.6	3.6	1.9	-1.6	-1.5	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	6.2	-2.2	2.3	1.4	2.5
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.1	0.2	-1.6	-1.8	-1.2
Qualifications: None of the above	0.8	1.7	3.6	1.0	-1.9	-1.2	-0.8
Financial difficulties in last 2 years	0.6	0.8	2.3	0.5	-0.8	-0.4	-1.5
Mouth/teeth dental problems	0.5	0.7	1.5	-0.5	1.0	1.2	0.0
Heart attack	1.1	1.4	1.8	1.3	-1.3	-1.3	-0.5
Allergy	0.3	0.7	1.7	-1.3	0.5	0.0	0.8
Pain all over the body in last month	1.8	1.9	4.5	-0.1	-1.7	-2.1	-0.5
Diabetes (self-reported)	1.5	2.3	3.3	-1.3	1.7	1.1	1.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	-0.8	-0.0	0.1	-0.3
Medication: Ramipril	0.6	0.8	1.4	0.2	-1.1	-1.2	-0.8
Medication: Simvastatin	0.8	1.2	2.0	0.9	-1.4	-1.4	-0.4
Fluid intelligence score	0.1	0.1	0.2	0.3	0.2	0.4	-0.4
Illnesses of siblings	2.5	3.5	6.6	2.6	-1.5	-1.6	-1.6
Neuroticism score	0.2	0.5	0.8	0.6	-0.6	-0.6	-0.9
Weight	0.2	0.8	2.2	-1.5	0.8	0.5	0.4
Impedance of arm (right)	0.2	0.7	1.4	0.2	1.1	1.2	0.3
Arm fat percentage (right)	0.4	1.4	2.9	-1.4	1.7	1.0	0.3
Trunk fat-free mass	0.1	0.4	1.0	-1.0	0.2	0.3	0.6
Hip circumference	0.4	1.8	3.1	-1.8	1.7	0.7	0.9
Time employed in main current job	0.1	0.1	0.2	0.4	0.3	0.5	-0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.0	0.4	-1.0	-0.8	-0.8
Father’s age at death	1.4	1.9	3.3	-1.5	1.8	0.7	1.2
Worrier / anxious feelings	0.8	1.5	2.6	0.4	-1.5	-1.0	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.0	0.8	-1.3	-1.7	-1.6
Falls in the last year	0.8	1.0	2.5	1.6	-0.3	0.3	-1.2
Hair/balding pattern: Pattern 3	1.5	2.2	6.0	-1.0	0.7	1.2	2.5
Number of live births	0.4	0.6	1.5	1.2	-0.5	-0.8	0.4
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.7	1.9	-1.0	-1.3	-1.2
Pulse rate	0.1	0.2	0.5	-0.1	-0.4	0.3	-0.7
Happiness	0.5	0.6	1.1	-0.0	-1.0	-1.0	-0.6
Noisy workplace	0.1	0.1	0.2	-0.0	-0.5	0.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.8	1.2	-0.5	-0.6	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.1	0.3	-0.4	-1.1	-0.4
Mouth/teeth dental problems: Dentures	0.4	0.6	1.0	0.6	-1.0	-0.1	-1.0
Asthma	0.8	1.6	4.5	1.1	-0.9	0.2	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	0.7	0.2	0.9	-1.1
Medication: Cholesterol lowering	0.4	0.6	0.9	0.9	-0.6	-0.8	-0.6
Depression (self-reported)	4.8	5.7	12.0	2.5	-1.9	-1.0	-3.5
Medication: Lansoprazole	1.2	1.4	3.0	-0.2	1.5	1.7	0.5
Prospective memory result	1.7	2.0	2.8	1.7	-1.6	-1.1	-1.2
Lung cancer (father)	0.1	0.2	0.3	-0.0	-0.5	-0.5	-0.2
Illnesses of mother	0.5	0.6	1.3	1.2	0.6	0.8	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.3	1.2	-1.0	-1.5	-0.6
Pulse wave Arterial Stiffness index	0.1	0.2	0.6	0.2	0.0	-0.2	0.7
Impedance of arm (left)	0.0	0.2	0.5	0.1	0.3	0.6	0.7
Arm fat mass (right)	0.2	1.0	1.7	-1.3	1.3	0.7	0.1
Trunk predicted mass	0.1	0.4	1.2	-1.1	0.2	0.2	0.7
Standing height	0.1	0.5	1.2	-0.8	0.1	0.4	1.1
Length of working week for main job	0.1	0.1	0.2	0.2	-0.4	-0.1	-0.0
Exposure to tobacco smoke at home	0.5	0.6	1.1	0.8	1.1	0.7	-0.1
Breastfed as a baby	1.9	2.3	5.9	-0.5	1.3	2.4	1.2
Tense / ‘highly strung’	0.4	0.7	1.0	0.8	1.0	0.9	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	8.7	13.3	34.6	3.6	-1.8	-1.6	-5.9
Hair/balding pattern: Pattern 4	3.7	8.9	19.2	-3.7	1.4	0.7	4.4
Birth weight of first child	0.4	0.6	2.3	0.4	0.1	0.3	-1.5
Peak expiratory flow (PEF)	0.2	0.5	1.3	1.2	-0.2	-0.2	-0.8
Pulse wave reflection index	0.7	0.9	2.4	0.2	-0.9	-1.6	0.6
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.0	1.0	-0.3	-0.4	-0.2
Loud music exposure frequency	5.6	6.2	8.8	2.6	-2.4	-1.8	-3.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	0.1	-0.5	0.6	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	0.4	-0.1	-1.0	0.3
Blood clot in the leg (DVT)	0.5	0.6	1.0	-1.0	1.0	0.4	0.6
Medication: Paracetamol	0.3	0.6	0.9	0.8	0.6	0.7	-0.9
Headache pain in last month	0.6	1.0	1.6	1.1	0.2	1.3	-1.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	0.4	-0.3	0.4	-0.9
Glaucoma (self-reported)	0.4	0.5	0.8	0.7	-0.7	-0.9	0.5
Gout (self-reported)	1.9	2.6	4.2	2.0	-1.1	-1.1	-1.9
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.3	0.2	0.7	-0.2
Medication: Amlodipine	1.4	2.0	3.0	-1.6	-1.0	-1.1	1.7
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.1	0.3	-0.3	0.1	-0.1
Birth weight	0.3	0.5	1.1	-0.2	1.1	0.9	0.4
Chronic bronchitis/emphysema (mother)	1.7	2.0	4.0	1.8	-0.8	0.2	-2.0
High blood pressure (siblings)	1.0	1.4	2.1	-1.5	0.9	1.0	1.3
Forced vital capacity (FVC), Best measure	0.3	1.1	2.4	0.9	-1.1	-1.5	-0.3
Body fat percentage	0.4	1.5	2.4	-1.6	1.5	1.0	0.2
Leg fat percentage (right)	0.3	1.0	2.1	-1.5	1.2	0.7	-0.0
Arm fat-free mass (right)	0.1	0.4	0.7	-0.9	-0.7	-0.6	0.0
Exposure to tobacco smoke outside home	1.3	1.7	4.0	2.0	-0.5	0.4	-1.6
Comparative body size at age 10	0.1	0.3	0.5	-0.7	0.2	-0.6	0.5
Number of full brothers	0.5	0.7	0.9	0.2	-1.0	-1.0	-0.9
Worry too long after embarrassment	0.9	1.6	3.0	1.3	-1.0	-0.7	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	5.7	1.4	0.1	0.2	-2.4
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	-0.8	0.5	0.8	-0.0
Number of children fathered	0.4	0.5	1.0	-1.0	0.2	0.7	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	4.3	0.3	-2.1	-1.8	-0.8
Age at first live birth	0.8	1.4	2.5	-1.1	1.6	1.4	-0.3
Pulse wave peak to peak time	0.2	0.2	0.7	-0.1	-0.1	0.2	-0.8
Health satisfaction	0.5	0.7	1.3	-1.1	-0.7	-0.9	0.0
Shortness of breath walking on level ground	2.0	2.3	3.7	0.7	-1.8	-1.9	-1.3
Qualifications: College or University degree	0.1	0.4	0.6	0.7	0.5	-0.3	-0.8
Eye problems/disorders: None of the above	1.1	1.3	2.0	-1.4	1.2	0.9	1.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.0	-1.0	-0.8	-0.8	0.2
Emphysema/chronic bronchitis	1.7	1.9	4.6	2.1	-0.7	-0.1	-1.6
Medication for pain relief, constipation, heartburn	0.5	0.8	2.2	-0.9	0.0	-0.6	1.5
Neck or shoulder pain in last month	4.8	6.8	9.7	3.1	-2.9	-2.1	-2.2
Medication: Blood pressure	0.3	0.5	1.3	-0.6	0.3	-0.3	1.1
Angina (self-reported)	0.6	0.8	1.6	-0.6	-0.6	-1.3	1.0
Migraine (self-reported)	0.2	0.3	0.7	0.0	0.5	0.9	-0.0
Medication: Ibuprofen	0.8	0.9	1.8	0.6	1.1	1.4	-0.7
Medication: Allopurinol	0.2	0.2	0.3	0.5	-0.4	-0.4	-0.6
Medication: Omeprazole	0.5	0.5	0.9	0.1	-0.7	-1.0	-0.9
Medication: Seretide 50 evohaler	0.4	0.5	0.9	0.8	-1.0	-0.3	-0.6
Mean time to correctly identify matches	0.1	0.1	0.4	-0.7	0.2	0.3	0.0
Heart disease (mother)	0.2	0.2	0.3	-0.4	0.5	-0.5	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.6	0.6	-0.6	-0.4	-0.8
Whole body fat mass	0.3	1.2	2.7	-1.6	1.2	0.8	0.1
Leg fat mass (right)	0.2	0.7	2.2	-1.5	0.8	0.2	-0.1
Arm predicted mass (right)	0.1	0.3	0.7	-0.8	-0.5	-0.4	0.1
Pulse rate, automated reading	0.2	0.7	1.4	1.0	-0.3	0.2	-1.2
Alcohol intake frequency.	0.1	0.2	0.5	-0.0	-0.7	-0.4	-0.1
Comparative height size at age 10	0.0	0.1	0.2	-0.4	-0.5	0.1	-0.4
Number of full sisters	0.4	0.4	1.0	1.0	0.7	0.4	-0.4
Suffer from ‘nerves’	0.4	0.6	1.8	1.3	0.3	0.2	-0.8
Overall health rating	1.6	3.5	5.3	0.7	-2.3	-2.0	-2.0
Chest pain or discomfort	0.7	1.0	2.6	1.1	-0.0	-0.4	-1.6
Had major operations	1.0	1.1	2.3	1.5	0.6	0.4	-1.3
Age at last live birth	0.1	0.1	0.2	-0.4	0.5	0.0	-0.5
Family relationship satisfaction	1.0	1.3	2.1	1.0	-0.6	-1.4	-1.2
Leg pain on walking	0.9	1.1	3.0	-0.9	-0.9	-1.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.8	0.4	0.9	0.3	0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	-0.3	0.1	0.5	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	0.6	-0.0	0.3	0.1
Medication: Aspirin	0.8	1.0	1.5	1.0	-1.2	-0.8	-0.9
Supplements: Vitamin C	2.7	3.2	4.9	1.3	-1.5	-2.2	-2.0
Knee pain experienced in last month	0.5	0.8	1.7	-1.3	-0.1	0.6	1.0
Hypertension (Self-reported)	1.1	3.1	7.3	-2.1	0.7	0.1	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	1.0	-0.4	-0.5	-1.0
Illnesses of father: Heart disease	0.7	1.0	1.2	0.9	-1.1	-1.0	-1.0
Illnesses of siblings: Diabetes	1.0	1.2	2.4	-1.4	0.5	0.3	1.5
Smoking status: Previous	0.1	0.2	0.4	-0.6	0.2	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.3	1.1	-0.8	-0.3	-0.3
Whole body fat-free mass	0.1	0.5	1.3	-1.1	0.3	0.3	0.7
Leg fat-free mass (right)	0.1	0.5	1.1	-1.1	0.5	0.2	0.7
Arm fat percentage (left)	0.3	1.2	2.2	-1.5	1.4	0.8	0.5
Average weekly red wine intake	0.1	0.2	0.4	-0.0	0.2	-0.6	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	0.9	-0.4	-0.1	-1.0
Mood swings	0.7	1.3	2.6	0.6	-1.1	-0.9	-1.6
Loneliness, isolation	1.5	2.1	4.1	0.6	-1.9	-0.6	-2.0
Long-standing illness, disability or infirmity	0.1	0.2	0.6	0.8	-0.3	-0.1	-0.4
Ever had bowel cancer screening	0.1	0.1	0.4	-0.2	0.6	0.3	-0.0
Diabetes diagnosed by doctor	0.9	1.5	2.1	-1.0	1.4	0.9	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	5.4	2.3	-0.5	-0.4	-1.3
Friendships satisfaction	1.2	1.5	2.8	1.2	-0.8	-1.7	-1.1
Qualifications: nursing, teaching	0.5	0.8	1.7	0.1	1.3	1.2	-0.4
Commuting to job workplace: Walk	1.1	1.2	2.8	1.7	0.3	0.6	-1.2
Eye problems/disorders: Cataract	0.3	0.4	1.0	1.0	-0.2	-0.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.7	-0.8	-0.4	-0.3
Medication for cholesterol	0.5	0.7	1.1	0.8	-0.8	-0.8	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.4	0.5	0.1	0.0	-0.6
Back pain experienced in last month	0.0	0.0	0.1	-0.2	-0.2	-0.0	0.1
Mineral and other dietary supplements	0.4	0.6	1.1	-0.6	0.8	1.1	0.5
Breast cancer (self-reported)	1.4	1.7	3.6	-1.9	-0.4	-0.4	1.7
Asthma (self-reported)	0.8	1.6	4.5	1.1	-0.4	0.7	-2.1
Osteoporosis (self-reported)	4.5	5.6	7.4	2.1	-2.1	-2.7	-2.4
Osteoarthritis (self-reported)	0.1	0.1	0.4	0.0	-0.6	-0.0	-0.2
Medication: Aspirin	1.5	2.0	2.4	1.5	-1.5	-1.1	-1.4
Medication: Gliclazide	1.8	2.1	3.9	-2.0	1.3	1.2	1.2
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	-0.4	-0.5	-0.2	-0.5
Smoking status: Current	0.3	0.5	1.3	0.3	-1.1	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	4.7	-0.2	-1.3	-2.2	0.0
Whole body water mass	0.1	0.5	1.4	-1.2	0.2	0.3	0.6
Leg predicted mass (right)	0.1	0.5	1.3	-1.1	0.5	0.2	0.8
Arm fat mass (left)	0.2	0.9	2.0	-1.4	1.1	0.5	0.3
Number of self-reported non-cancer illnesses	0.3	0.6	1.6	0.5	-0.6	-0.3	-1.3
Average weekly champagne plus white wine intake	1.4	1.9	4.5	-2.1	0.6	0.9	1.4
Miserableness	3.7	6.4	8.1	2.1	-2.8	-2.7	-2.4
Guilty feelings	0.1	0.2	0.6	-0.1	-0.8	-0.4	0.1
Wears glasses or contact lenses	0.6	0.7	2.4	-1.5	0.4	-0.1	0.5
Ever taken oral contraceptive pill	2.5	2.8	6.7	2.6	-1.0	-0.3	-1.9
Hearing aid user	1.3	1.4	3.4	1.5	-0.3	-0.3	-1.9
Mother’s age at death	0.3	0.3	0.5	-0.7	0.4	0.6	0.6
Financial situation satisfaction	0.2	0.3	0.4	-0.6	-0.3	-0.7	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.5	-0.1	0.1	0.7	0.1
Commuting to job workplace: Public transport	1.5	1.7	3.7	-1.9	1.3	1.2	0.5
Eye problems/disorders: Glaucoma	1.1	1.3	2.3	0.5	1.5	1.3	1.0
Medication: Blood pressure	1.1	2.1	4.6	-1.7	0.8	0.6	2.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-1.0	-0.1	-0.5	0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.1	0.1	-0.3	-0.2	-0.3
High cholesterol (Self-reported)	0.2	0.4	0.6	0.5	-0.7	-0.8	-0.5
Medication: Bendroflumethiazide	2.3	3.5	4.6	-1.5	2.2	2.1	1.6
Medication: Paracetamol	0.4	0.6	0.9	0.9	0.4	0.8	-0.9
Medication: Lisinopril	0.7	0.9	1.3	-0.8	0.8	1.1	1.0
Medication: Atorvastatin	1.1	1.3	4.0	0.2	-1.1	-2.0	0.3
Illnesses of father: High blood pressure	0.2	0.2	0.3	0.3	-0.4	-0.6	-0.5
Alcohol drinker status: Never	0.1	0.2	0.4	0.2	-0.1	0.7	-0.5
Ever smoked	0.4	0.6	1.4	-0.3	-1.2	-1.0	-0.0
Basal metabolic rate	0.1	0.4	1.2	-1.1	0.4	0.3	0.4
Leg fat percentage (left)	0.3	1.2	2.8	-1.7	1.2	0.6	0.1
Arm fat-free mass (left)	0.0	0.2	0.8	-0.9	-0.0	-0.0	-0.1
Number of operations (self-reported)	2.0	3.0	5.2	2.3	-1.5	-0.6	-2.0
Average weekly beer plus cider intake	1.7	2.5	4.5	1.9	-2.1	-1.1	-1.0
Irritability	0.3	0.6	1.4	1.2	-0.0	-0.2	-0.9
Risk taking	0.0	0.1	0.1	0.3	0.1	-0.2	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	0.1	-0.4	-0.6	-0.6
Fractured/broken bones in last 5 years	2.6	3.3	4.9	1.6	-2.2	-1.9	-1.6
Age started oral contraceptive pill	1.2	1.5	2.3	0.6	-1.5	-1.2	-1.4
Diastolic blood pressure, automated reading	0.7	2.2	2.9	-1.6	1.4	1.7	1.1
Ever depressed for a whole week	1.2	1.5	2.3	-0.4	-1.5	-1.5	-1.1
Unable to work because of sickness or disability	0.3	0.4	0.6	0.4	-0.6	-0.8	-0.6
Commuting to job workplace: Cycle	0.2	0.3	0.4	-0.6	0.5	-0.4	0.5
Myopia	0.7	1.0	2.4	0.3	-1.2	-1.6	0.0
Vascular/heart problems diagnosed by doctor	0.8	2.2	5.6	1.8	-0.3	0.2	-2.4
Cholesterol lowering medication	0.2	0.3	0.6	-0.2	-0.8	-0.5	0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.2	0.2	-0.9	-1.0	-1.1
Pain experienced in last month	0.2	0.4	0.8	-0.7	0.2	-0.4	0.9
Supplements: Calcium	2.7	2.9	7.9	1.8	-0.7	-0.5	-2.8
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.5	0.2	0.2	-0.1
Heart attack/myocardial infarction (self-reported)	1.4	1.8	2.4	1.6	-1.4	-1.5	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.0	-1.0	1.0	0.6	0.9
Heart disease (siblings)	0.8	1.0	1.6	-0.9	1.1	1.3	0.4
Alcohol drinker status: Previous	0.7	0.7	1.2	1.1	-1.0	-0.0	-0.8
Pack years of smoking	0.8	1.2	2.2	-1.5	0.8	0.8	1.1
Impedance of whole body	0.1	0.3	0.6	0.7	0.2	0.8	-0.2
Leg fat mass (left)	0.2	0.9	2.5	-1.6	0.9	0.4	0.0
Arm predicted mass (left)	0.1	0.3	1.2	-1.1	0.3	0.3	0.2