TWAS hub - P2RX1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.5270	0.1400	6.5e-03	0.008	NA	0.169	NA	0.128	2.1e-01	NA	8.0e-05	NA	6.3e-04
2	GTEx	Esophagus Muscularis	0.2020	0.0700	3.7e-03	0.097	NA	0.061	NA	0.075	1.8e-06	NA	1.4e-04	NA	2.5e-05
3	GTEx	Whole Blood	0.4820	0.0460	0.0e+00	0.371	NA	0.340	NA	0.360	8.0e-36	NA	2.8e-32	NA	1.6e-34
4	METSIM	Adipose	0.1895	0.0424	3.6e-08	0.099	0.078	0.090	0.095	0.095	1.4e-14	9.2e-12	2.2e-13	4.7e-14	4.2e-14
5	NTR	Blood	0.0267	0.0157	2.6e-02	0.000	0.001	0.009	0.003	0.001	2.6e-01	2.0e-01	5.6e-04	2.7e-02	1.7e-01
6	YFS	Blood	0.5619	0.0270	0.0e+00	0.543	0.551	0.580	0.578	0.576	7.2e-217	8.9e-222	5.0e-240	1.1e-238	1.3e-237
7	TCGA	Breast Invasive Carcinoma	0.0214	0.0113	6.2e-03	0.004	0.006	0.005	NA	0.007	5.2e-02	1.7e-02	3.4e-02	NA	9.9e-03
8	TCGA	Lung Adenocarcinoma	0.0455	0.0185	5.9e-04	0.021	0.022	0.007	NA	0.017	1.3e-03	1.1e-03	4.6e-02	NA	4.0e-03
9	TCGA	Lung Squamous Cell Carcinoma	0.0328	0.0162	6.3e-03	0.028	0.010	0.018	NA	0.024	3.4e-04	2.5e-02	3.4e-03	NA	8.4e-04
10	TCGA	Rectum Adenocarcinoma	0.3280	0.1200	3.7e-03	0.001	0.049	-0.012	NA	-0.012	3.0e-01	2.7e-02	8.7e-01	NA	7.8e-01
11	TCGA	Thyroid Carcinoma	0.0480	0.0230	4.1e-03	0.000	0.025	0.006	NA	0.003	3.2e-01	1.5e-03	7.7e-02	NA	1.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Hair/balding pattern: Pattern 2	3.3	4.3	8.9	-1.1	-0.9	-2.8	-3.0	0.8	-2.7	-1.7	-1.9	-2.8	0.7	-2.2
Frequency of depressed mood in last 2 weeks	3.2	4.4	9.9	-2.3	0.3	-3.1	-3.0	0.8	-2.9	-1.2	-1.3	-2.8	-0.5	-2.1
Triglycerides	3.1	5.0	8.8	0.9	1.8	2.4	2.7	-0.1	2.7	2.8	2.7	2.6	0.3	3.0
Medication: Atenolol	2.8	3.5	8.9	-0.5	-0.3	-1.8	-1.6	-0.8	-2.1	-3.0	-2.4	-2.0	0.3	-2.8
HDL Cholesterol	2.7	4.5	11.9	-1.2	-1.1	-2.4	-2.5	1.2	-2.7	-2.2	-2.2	-2.2	0.3	-3.4
Length of working week for main job	2.7	3.0	6.0	0.8	-0.9	-2.2	-1.9	2.5	-1.9	-1.8	-1.3	-2.1	-1.4	-1.5
Depression (Nagel 2018)	2.6	3.9	7.4	-2.6	0.7	-2.6	-2.4	1.6	-2.7	-1.1	-1.1	-2.3	0.1	-2.3
Ever depressed for a whole week	2.6	3.3	6.3	-1.5	-1.3	-2.2	-2.1	-1.4	-1.9	-1.9	-2.5	-2.2	0.8	-1.5
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.8	4.8	-0.9	1.3	-2.0	-1.8	-0.5	-2.2	-1.8	-2.0	-1.9	1.6	-1.8
Ever highly irritable/argumentative for 2 days	2.5	3.0	5.6	-0.1	-1.9	-2.4	-2.3	0.7	-2.2	-1.3	-1.6	-2.1	-1.5	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.9	5.1	-1.2	-2.0	-2.2	-2.3	-1.0	-2.0	-0.8	-1.6	-2.2	-0.3	-1.8
Chronic bronchitis/emphysema (mother)	2.3	2.7	12.1	-0.5	0.5	-1.6	-1.4	1.1	-1.4	1.0	-2.3	-1.2	3.5	-1.1
Medication: Blood pressure	2.3	4.3	8.8	-1.6	-1.3	-2.0	-1.8	-2.6	-2.3	-3.0	-1.9	-2.3	0.1	-2.5
Blood Platelet Count	2.2	25.1	44.5	-5.5	0.6	-6.4	-6.0	-1.2	-6.5	-3.6	-5.6	-5.6	2.2	-6.7
Relative age voice broke	2.2	3.4	6.3	-1.1	-2.0	-2.0	-2.1	-0.4	-1.9	-2.5	-1.7	-2.2	1.7	-1.6
Had other major operations	2.2	2.7	4.1	-0.2	-1.6	-1.7	-2.0	1.5	-1.9	-2.0	-1.8	-1.9	-0.9	-1.6
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	5.5	1.6	-0.6	2.4	2.2	0.1	2.1	1.1	1.6	2.2	0.4	1.8
Number of full sisters	2.1	2.6	5.4	-0.4	0.7	-1.9	-1.7	0.6	-1.9	-1.7	-2.3	-2.1	1.3	-1.6
Breast cancer (self-reported)	2.1	2.5	11.8	2.5	-3.4	-0.8	-1.0	1.6	-0.7	-1.0	-0.3	-1.0	-1.5	-0.5
LDL Cholesterol	2.0	3.1	9.4	2.0	0.8	1.5	1.5	0.7	1.8	2.0	3.1	1.7	-1.0	2.0
Blood clot in the leg (DVT)	2.0	2.6	4.4	1.6	0.3	1.9	1.8	-2.1	2.0	1.3	1.1	2.0	-0.4	1.9
Medication: Seretide 50 evohaler	2.0	2.3	4.7	-0.8	-1.1	-1.9	-1.9	-0.0	-1.9	-1.0	-1.8	-1.9	-0.6	-2.2
Leg pain on walking	2.0	2.5	6.4	-0.0	-0.7	-1.8	-1.8	0.2	-2.1	-2.5	-0.5	-2.0	-1.6	-1.5
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	3.9	1.5	0.3	1.9	1.8	-1.8	1.9	1.3	1.2	2.0	-0.6	1.8
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	4.2	-0.5	1.1	2.0	2.0	1.6	1.6	1.6	0.2	1.9	0.9	1.3
Medication: Atorvastatin	1.8	2.2	6.2	-1.2	-1.4	-1.8	-1.9	-1.3	-1.6	-0.8	-0.3	-1.6	0.8	-2.5
Irritability	1.8	3.0	6.2	-1.9	-0.0	-2.5	-2.4	0.7	-2.0	-0.8	-2.3	-2.2	0.4	-1.5
Neuroticism	1.7	4.2	6.9	-1.2	-1.9	-2.5	-2.5	1.9	-2.3	-2.0	-2.6	-2.5	-0.7	-1.4
Hypertension (Self-reported)	1.7	4.7	10.6	-1.2	-2.1	-2.3	-2.2	-1.9	-2.3	-3.3	-2.4	-2.6	-0.6	-2.0
Eye problems/disorders: Cataract	1.7	2.0	8.2	-1.3	-0.1	-1.6	-1.6	1.4	-1.7	-0.2	-0.3	-1.4	0.3	-2.9
Average weekly fortified wine intake	1.6	1.9	6.0	-1.5	-0.7	-1.1	-1.2	-2.5	-1.5	-1.5	-1.2	-1.4	-0.1	-1.2
Pulse wave peak to peak time	1.6	1.9	4.6	0.1	-0.6	-1.9	-1.8	-0.7	-1.9	-0.8	-2.1	-1.8	0.5	-0.7
Medication: Allopurinol	1.6	2.2	5.8	-0.8	-0.5	-1.5	-1.6	-1.0	-1.7	-1.2	-1.8	-1.4	1.3	-2.4
Commuting to job workplace: Public transport	1.6	1.9	4.1	0.6	0.6	1.7	1.8	-0.7	2.0	1.4	1.3	1.8	0.8	1.5
Body Mass Index (BMI) (2010)	1.5	2.0	4.2	1.0	0.9	1.6	1.5	0.6	1.8	2.1	1.7	1.6	0.0	1.6
Allergy	1.5	3.6	11.3	-2.0	-0.4	-1.5	-1.5	0.6	-1.9	-2.3	-3.4	-1.8	2.1	-1.4
Pulse wave Arterial Stiffness index	1.5	1.7	3.9	-0.1	0.5	1.9	1.8	0.8	1.8	0.7	2.0	1.8	-0.5	0.6
Headache pain in last month	1.5	2.5	6.4	-1.8	2.5	1.2	1.4	-0.4	1.3	1.8	0.3	1.5	2.4	1.2
High blood pressure (siblings)	1.5	2.1	7.3	-1.1	-0.4	-1.3	-1.4	-0.8	-1.4	-2.7	-1.6	-1.7	-0.7	-1.6
Medication: Blood pressure	1.5	2.6	5.1	-1.4	-2.0	-1.1	-1.2	-2.0	-1.2	-2.3	-2.1	-1.5	-1.4	-1.0
Smoking status: Previous	1.5	2.2	4.3	-0.4	-1.9	-1.3	-1.5	-1.1	-1.3	-1.7	-2.1	-1.5	-1.5	-1.3
Friendships satisfaction	1.5	1.9	3.6	-0.8	-1.1	-1.8	-1.7	-0.4	-1.6	-1.9	-1.4	-1.9	0.2	-0.9
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	5.2	-2.0	0.6	-2.3	-2.0	0.3	-1.8	-0.0	-1.7	-1.8	-0.4	-0.9
Had menopause	1.4	1.8	4.8	0.2	-2.0	-1.1	-1.3	-1.8	-0.9	-1.3	-2.2	-1.3	-0.2	-0.9
Age at last live birth	1.4	2.1	6.1	1.4	0.1	1.1	1.1	-1.2	1.7	1.4	2.5	1.0	-0.9	2.0
Ever had bowel cancer screening	1.4	1.6	6.6	-0.8	0.5	-1.3	-1.2	0.4	-1.0	-0.6	-2.6	-1.1	1.5	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.3	0.3	-1.5	-1.7	-1.9	0.2	-1.8	-2.1	-1.6	-1.9	0.6	-1.3
Heart disease (siblings)	1.4	1.8	3.6	0.2	-1.3	-1.6	-1.7	0.3	-1.7	-0.5	-1.8	-1.5	0.3	-1.9
Diabetes (mother)	1.3	1.7	4.3	-0.2	0.9	1.5	1.5	-2.1	1.0	-0.1	2.1	1.4	1.2	-0.2
Suffer from ‘nerves’	1.3	2.0	4.9	2.1	-2.0	-1.0	-1.1	2.2	-0.8	-1.4	-0.7	-1.3	-1.4	0.1
Depressed Affect (Nagel 2018)	1.2	2.6	5.5	-2.3	-0.1	-1.9	-1.8	0.5	-2.1	-1.3	-1.9	-1.8	0.3	-1.6
Lung FEV1/FVC ratio	1.2	6.3	12.2	3.5	1.0	3.0	3.0	-1.3	2.8	2.1	3.0	2.9	-0.6	2.4
Taking other prescription medications	1.2	1.8	4.5	-0.1	-1.0	-1.4	-1.4	0.0	-1.1	-2.0	-2.1	-1.4	-0.5	-1.8
High blood pressure	1.2	3.5	8.0	-1.2	-1.9	-1.8	-1.8	-1.9	-1.8	-2.8	-1.9	-2.1	-0.1	-1.9
Neuroticism score	1.2	2.6	4.5	-1.5	-1.0	-2.1	-2.1	1.4	-1.7	-1.3	-2.0	-2.1	-0.4	-1.0
Medication: Lansoprazole	1.2	1.4	2.5	0.2	0.2	-1.4	-1.3	-1.4	-1.6	-0.3	-1.6	-1.3	1.4	-0.7
Tense / ‘highly strung’	1.2	2.0	5.9	-1.1	-1.5	-1.6	-1.7	1.3	-1.3	-0.7	-2.4	-1.6	-1.0	-0.3
Emphysema/chronic bronchitis	1.2	1.3	7.2	1.2	-0.3	-0.4	-0.3	2.7	-0.1	-0.1	-1.3	-0.5	-1.9	-0.6
Had major operations	1.2	1.4	4.0	-0.9	-1.5	-0.7	-0.9	-2.0	-0.5	-2.0	-0.9	-0.8	1.0	-0.6
Family relationship satisfaction	1.2	1.5	6.0	-0.5	-0.0	-1.2	-1.1	-0.6	-1.1	-1.3	-2.5	-1.3	1.3	-0.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	4.9	2.2	-1.6	1.0	0.9	-1.3	1.1	-0.3	0.4	0.6	0.3	-0.1
Glaucoma (self-reported)	1.1	1.3	3.4	0.7	-1.9	-0.9	-1.2	1.8	-1.1	-0.9	-1.2	-1.1	-0.1	-0.8
Diabetes diagnosed by doctor	1.1	1.7	6.1	1.2	0.0	1.3	1.3	-2.2	0.8	-0.6	2.5	1.1	0.6	-0.9
Osteoarthritis (self-reported)	1.1	1.4	5.0	-1.5	-0.3	-1.3	-1.1	-0.8	-0.9	-0.3	-1.1	-0.9	-2.2	-1.1
Smoking status: Current	1.1	1.8	4.4	0.0	1.4	0.9	1.1	0.7	1.1	1.5	2.1	1.0	1.6	1.9
Number of self-reported non-cancer illnesses	1.1	1.9	5.1	-0.1	-1.6	-1.6	-1.6	0.0	-1.4	-0.8	-2.2	-1.6	-1.4	-1.2
Eye problems/disorders: Glaucoma	1.1	1.3	3.6	0.3	-1.6	-0.9	-1.0	1.9	-1.0	-1.4	-1.3	-1.1	-0.3	-0.8
Worry (Nagel 2018)	1.0	2.1	7.7	0.4	-2.1	-0.7	-1.0	2.8	-0.5	-1.1	-0.8	-0.9	-2.6	-0.2
Angina	1.0	1.3	3.2	1.7	-1.2	-0.9	-0.8	1.3	-0.5	-1.8	-0.5	-1.0	-1.1	-0.8
Medication: Co-codamol	1.0	1.2	3.4	-1.9	1.5	0.9	0.9	-0.6	0.6	1.0	1.7	0.9	-0.0	-0.3
Medication: Metformin	1.0	1.4	5.8	-0.4	-1.2	-0.8	-0.8	-2.4	-0.9	-1.3	0.2	-0.9	0.7	-1.8
Number of incorrect matches in round	1.0	1.6	9.4	-3.1	2.3	0.3	0.3	0.0	-0.3	0.3	-0.1	0.3	0.8	-1.4
Happiness	1.0	1.2	3.9	-0.3	-0.3	-1.2	-1.2	0.4	-1.1	-1.1	-2.0	-1.2	1.2	-0.8
Angina (self-reported)	1.0	1.3	3.5	1.6	-1.2	-0.9	-0.8	1.4	-0.5	-1.9	-0.6	-1.0	-1.3	-0.9
Alcohol intake frequency.	1.0	2.4	5.9	-0.2	2.4	1.5	1.6	-0.9	1.5	0.8	2.2	1.6	-2.0	0.2
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.5	0.8	-0.3	-1.1	-1.1	1.9	-1.2	-0.6	-0.9	-1.1	-1.1	-0.5
Average weekly red wine intake	1.0	1.5	4.4	-0.3	1.1	0.9	1.1	1.4	0.9	2.1	1.6	1.3	0.8	1.3
Mood swings	1.0	1.8	4.4	-2.1	0.0	-1.8	-1.8	-1.5	-1.4	0.8	-1.4	-1.4	0.5	-0.3
Number of operations (self-reported)	1.0	1.5	4.0	-0.3	-1.2	-1.2	-1.1	0.3	-1.3	-2.0	-2.0	-1.2	-0.6	-1.0
Heart attack/myocardial infarction (self-reported)	1.0	1.3	4.8	-0.5	-0.6	-1.0	-0.8	-1.2	-0.9	-2.2	-0.6	-1.0	-1.8	-0.4
Neuroticism (Nagel 2018)	0.9	2.1	3.1	-1.1	-1.1	-1.5	-1.6	1.8	-1.5	-1.4	-1.5	-1.6	-0.9	-1.5
Diabetes (father)	0.9	1.1	7.7	0.8	-1.5	-0.3	-0.2	-2.8	-0.2	-0.6	-0.1	-0.4	-0.1	-0.4
Current tobacco smoking	0.9	1.4	3.1	-0.0	1.1	0.6	0.8	1.1	0.8	1.5	1.8	0.7	1.6	1.8
Fed-up feelings	0.9	1.7	5.0	-2.2	1.1	-1.8	-1.4	-0.1	-1.6	-0.2	-1.4	-1.3	0.7	-0.8
Chronic bronchitis/emphysema (father)	0.9	1.1	2.9	0.8	-1.3	-1.0	-1.3	0.4	-0.7	-0.6	-0.1	-1.1	-1.7	-1.4
Diabetes (self-reported)	0.9	1.3	5.2	1.8	-0.6	0.9	0.9	-1.2	0.5	-1.0	2.3	0.7	0.5	-0.9
Alcohol intake versus 10 years previously	0.9	1.4	8.1	2.9	-1.0	0.4	0.2	0.3	0.6	0.6	2.1	0.4	-0.9	-0.1
Depression (self-reported)	0.9	1.1	2.3	-0.5	1.3	-1.5	-1.4	1.2	-1.3	-0.2	-0.7	-1.3	0.1	-0.3
Impedance of arm (left)	0.9	4.1	8.2	2.3	-2.6	-2.1	-2.3	1.7	-2.0	-1.0	-2.9	-2.1	-0.7	-1.4
Neck or shoulder pain in last month	0.9	1.2	5.5	-1.1	1.0	-0.8	-0.8	-2.3	-0.9	0.2	-0.5	-0.8	-0.5	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	4.3	1.5	-1.0	-0.5	-0.3	0.5	0.1	0.2	0.4	-0.4	-2.1	1.3
Financial situation satisfaction	0.9	1.2	4.1	-0.3	-0.9	-1.1	-1.1	-0.5	-1.1	-1.4	-2.0	-1.2	0.2	-0.8
Medication: Paracetamol	0.9	1.3	4.6	-2.2	0.8	-0.9	-0.7	0.0	-0.9	-1.5	-0.4	-0.8	0.2	-2.1
Alzheimer’s Disease (in father)	0.8	0.8	4.5	-0.8	2.1	0.2	0.6	-0.4	0.2	-0.5	1.6	0.3	-0.7	0.2
Ovarian Cancer	0.8	1.1	2.9	0.2	-1.0	-1.1	-1.3	0.1	-1.2	-1.7	-1.2	-1.3	0.9	-0.4
Fasting Glucose	0.8	1.0	3.8	1.9	-1.6	-0.0	-0.1	-1.5	0.0	-0.8	-0.6	-0.3	0.1	-0.9
HbA1C	0.8	0.8	2.4	0.1	0.5	1.3	1.2	-0.6	1.0	0.6	1.5	1.2	0.2	0.4
Type 2 Diabetes (T2D) (2018)	0.8	1.5	6.5	1.1	-1.2	0.5	0.3	-2.0	0.1	-0.9	2.6	0.3	0.4	-1.5
Hand grip strength (left)	0.8	2.0	8.6	-1.5	1.9	0.2	0.3	1.2	0.3	1.7	1.2	0.5	2.9	1.4
Vitamin and mineral supplements	0.8	1.0	2.2	0.0	-1.5	-1.4	-1.5	-0.1	-1.1	-0.5	-1.3	-1.5	0.5	-0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.3	-0.2	1.2	0.9	1.0	1.5	0.6	0.0	1.2	0.8	1.0	-0.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	6.4	2.0	-0.3	0.9	0.9	0.2	1.2	1.4	2.5	1.0	-1.1	1.2
Nervous feelings	0.8	1.5	5.5	0.6	-2.4	-0.8	-1.1	1.5	-0.7	-1.1	-1.1	-1.1	-1.7	-0.1
Financial difficulties in last 2 years	0.8	1.1	4.3	-1.7	0.4	-1.1	-1.0	0.9	-0.7	0.7	-0.3	-0.8	-2.1	-0.1
Heart attack	0.8	1.0	4.8	-0.6	-0.6	-0.7	-0.5	-1.1	-0.6	-2.2	-0.4	-0.8	-1.6	-0.1
Impedance of arm (right)	0.8	3.9	8.9	2.6	-3.0	-1.8	-2.2	1.6	-1.7	-0.7	-2.8	-2.0	-0.7	-0.9
Time employed in main current job	0.8	0.9	2.0	-0.6	-0.6	-1.1	-1.2	-0.0	-1.0	-0.8	-1.1	-1.1	-0.8	-1.4
Number of live births	0.8	1.1	5.9	2.4	-0.7	0.3	-0.0	-1.1	0.3	0.5	0.1	0.1	-2.0	0.3
Loud music exposure frequency	0.8	0.8	4.2	-0.4	-0.6	-0.6	-0.5	-2.0	-0.4	-0.8	-1.6	-0.6	-0.3	0.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	4.6	0.1	1.8	0.4	0.5	1.3	0.6	2.2	1.3	0.9	0.8	0.9
Shortness of breath walking on level ground	0.8	1.0	2.0	-0.4	-0.7	-1.4	-1.2	1.0	-1.0	-1.0	-1.4	-1.2	-0.3	-0.1
Eye problems/disorders: None of the above	0.8	0.9	3.1	-0.9	1.2	0.9	1.1	-0.9	0.8	0.3	0.1	1.0	-0.6	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	4.2	-0.7	0.2	-0.9	-0.9	2.0	-0.9	-0.4	0.5	-0.8	-1.0	-1.0
Overall health rating	0.8	1.7	4.3	-0.1	-0.5	-1.3	-1.2	0.9	-1.3	-1.9	-2.1	-1.4	-0.5	-1.7
Illnesses of siblings: Diabetes	0.8	0.9	5.7	2.4	-1.4	0.8	0.7	-0.0	0.8	0.2	0.4	0.7	-0.5	0.2
Medication: Aspirin	0.8	1.1	5.9	-0.9	-1.2	-0.3	-0.4	-0.7	-0.6	-2.4	-0.3	-0.7	-0.2	-1.5
Medication: Lisinopril	0.8	1.0	7.5	-1.0	0.4	0.5	0.7	-2.7	0.3	-0.6	0.3	0.3	0.4	-0.7
Pain experienced in last month	0.8	1.3	4.2	2.1	-0.8	0.9	0.8	1.7	0.8	1.0	0.8	0.8	-0.5	1.1
Breast Cancer	0.7	1.8	4.4	-0.7	0.8	-1.8	-1.9	1.0	-2.1	-0.3	-0.5	-1.7	0.3	-1.8
Prostate Cancer	0.7	0.9	2.2	0.4	-1.5	-1.1	-1.2	0.7	-1.0	-0.6	-1.3	-1.2	-0.2	-0.2
Average weekly spirits intake	0.7	0.9	3.5	-0.6	1.5	0.7	0.9	0.1	0.5	-0.0	0.3	0.9	-1.9	-1.0
Hand grip strength (right)	0.7	1.9	5.2	-1.1	1.9	0.5	0.8	0.4	0.8	1.5	2.0	0.9	2.3	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.3	-1.2	1.5	-1.3	-1.1	0.0	-1.1	0.3	0.0	-0.9	1.0	-0.5
Alcohol usually taken with meals	0.7	1.1	2.0	0.1	1.2	1.2	1.2	0.6	1.2	1.1	0.8	1.3	0.8	1.4
Hearing difficulty/problems with background noise	0.7	1.2	2.0	0.4	1.3	1.0	1.1	-0.9	1.1	1.4	1.1	1.2	-0.8	1.3
Fluid intelligence score	0.7	1.4	4.6	2.1	-0.8	1.0	0.9	1.0	1.2	0.4	2.0	1.0	-0.2	1.0
Mouth/teeth dental problems: Loose teeth	0.7	0.8	3.4	0.6	-0.5	0.7	0.7	0.1	1.1	-0.4	0.8	0.5	-1.4	1.8
Heart disease (mother)	0.7	0.8	2.5	0.7	0.6	-0.4	-0.5	1.6	-0.4	-1.1	-1.3	-0.6	0.5	-1.3
Knee pain experienced in last month	0.7	1.0	4.1	-2.0	0.4	-0.6	-0.7	-1.8	-0.7	0.3	0.1	-0.4	0.8	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	4.3	-1.3	2.1	-0.2	0.1	0.4	-0.2	1.1	-0.0	0.3	0.9	-0.8
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.4	0.0	-1.1	-0.9	-1.1	0.7	-0.9	-0.8	-0.4	-1.1	0.4	-1.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.1	-0.1	-0.9	-0.8	-0.9	-0.5	-0.9	-1.4	-0.9	-1.1	-0.1	-1.1
Vascular/heart problems diagnosed by doctor	0.7	2.0	8.6	0.2	1.6	1.0	1.0	1.4	0.9	2.9	1.5	1.3	0.7	1.4
Crohns Disease (2012)	0.6	0.9	2.6	1.1	-1.2	-1.2	-1.3	-1.6	-1.2	0.0	0.0	0.0	0.0	0.0
Allergy or Eczema	0.6	1.5	6.0	1.6	-0.6	0.8	0.7	-0.2	1.1	1.4	2.4	0.8	-1.7	0.7
Cardiovascular Disease	0.6	2.1	3.3	-1.0	-1.7	-1.4	-1.5	-1.5	-1.4	-1.8	-1.8	-1.7	-0.3	-0.9
Number of treatments/medications taken	0.6	1.0	2.9	-1.1	-0.3	-0.5	-0.6	-0.7	-0.7	-1.5	-0.8	-0.7	-1.3	-1.7
Pack years adult smoking proportion	0.6	0.9	3.1	0.0	1.8	1.1	1.2	-0.8	0.9	0.1	1.0	0.9	0.1	0.8
Townsend deprivation index at recruitment	0.6	0.8	2.0	-0.1	-1.2	-1.0	-1.1	0.4	-0.9	-1.4	-0.4	-1.0	-0.3	-1.0
Qualifications: CSEs or equivalent	0.6	0.8	4.2	-0.6	2.0	0.3	0.6	-0.6	0.4	1.5	0.4	0.6	-0.1	0.7
Serious illness, injury or assault to yourself	0.6	0.7	3.8	-0.1	0.2	0.2	0.3	1.5	0.1	-0.9	0.4	0.2	-1.9	-0.4
Medication: Levothyroxine sodium	0.6	1.0	2.2	0.9	0.4	1.4	1.3	0.1	1.5	1.0	1.2	1.5	0.3	0.2
Medication: Simvastatin	0.6	0.9	7.0	-0.3	-1.0	0.3	0.3	-0.5	-0.0	-2.6	-0.4	-0.3	-0.5	-0.6
Hair/balding pattern: Pattern 3	0.6	0.9	2.0	-1.4	0.6	-0.7	-0.6	-1.3	-0.7	-1.0	-0.8	-0.6	-1.1	-1.2
Medication: Amlodipine	0.6	0.8	1.8	-0.4	-0.9	-1.2	-1.2	0.2	-1.0	-0.6	-0.2	-1.3	-0.8	-1.2
Comparative body size at age 10	0.6	1.8	4.2	0.6	0.9	1.2	1.5	-0.2	1.4	2.1	1.7	1.6	-1.1	1.4
Number of children fathered	0.6	0.6	3.1	-0.8	1.8	0.6	0.7	-0.4	0.2	0.6	1.1	0.6	0.3	-0.6
Age at first live birth	0.6	1.1	6.3	0.5	0.3	0.9	0.9	0.1	1.0	0.9	2.5	0.8	-0.2	1.2
Supplements: Vitamin C	0.6	0.7	1.8	1.4	1.1	0.7	0.8	0.1	0.9	0.7	1.0	0.8	-0.2	0.1
Loneliness, isolation	0.6	0.9	1.6	-1.2	0.0	-1.2	-1.1	0.1	-1.2	-0.8	-1.2	-1.1	0.9	-0.1
Commuting to job workplace: Walk	0.6	0.7	3.8	-1.1	-0.1	0.2	0.3	-0.8	0.0	-0.8	-0.9	0.0	1.9	-0.1
Mineral and other dietary supplements	0.6	0.8	1.7	-0.6	-0.2	-1.1	-1.0	-0.8	-1.1	-0.7	-0.6	-1.1	1.3	-0.7
Pain type(s) experienced in last month: Hip pain	0.6	0.8	4.1	-2.0	1.3	-0.5	-0.2	-1.3	-0.2	-0.3	0.3	-0.2	-0.6	-0.2
Fractured/broken bones in last 5 years	0.6	0.7	1.8	1.3	0.1	0.6	0.6	-1.3	0.8	0.4	1.0	0.7	-0.0	1.2
Alcohol drinker status: Previous	0.6	0.6	4.4	-2.1	1.1	-0.2	-0.2	-0.3	-0.4	0.8	-0.2	0.1	0.1	-0.7
Pack years of smoking	0.6	0.9	3.2	-0.1	1.8	1.1	1.2	-0.9	1.0	0.3	0.7	1.0	0.3	0.8
Mean Putamen Volume	0.5	0.6	2.0	-0.3	-0.7	0.7	0.5	-1.4	0.4	-0.9	0.9	0.4	-1.0	-0.6
Neuroticism (2016)	0.5	0.8	3.3	0.3	-1.8	-0.6	-0.8	0.4	-0.2	-0.8	-1.5	-0.6	-0.7	-0.2
Chronotype (morning person)	0.5	1.0	7.5	0.1	0.4	0.9	0.8	-2.7	0.7	0.5	1.0	0.7	-0.4	-0.3
Medication for hormone replacement therapy	0.5	0.6	1.9	0.2	0.1	1.0	1.1	0.5	0.7	0.2	0.1	0.6	1.4	1.0
Multivitamins +/- minerals	0.5	0.6	1.8	0.3	0.4	1.3	1.3	-0.5	0.9	0.4	0.7	1.3	0.2	0.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.3	-0.4	-0.7	-0.9	-0.8	-0.2	-0.6	-0.8	-1.5	-1.0	0.8	0.1
Falls in the last year	0.5	0.6	2.7	-1.7	0.8	0.3	0.4	-1.2	0.2	-0.4	-0.1	0.3	1.1	-0.1
Asthma	0.5	1.1	4.9	0.0	0.9	0.4	0.6	0.4	0.7	2.2	1.6	0.9	-1.2	0.1
Breastfed as a baby	0.5	0.6	1.2	1.0	-1.0	1.1	0.7	-0.9	1.0	0.6	0.1	0.9	-0.6	0.4
Arm fat-free mass (right)	0.5	2.4	4.8	-2.0	1.9	1.3	1.6	-2.0	1.4	0.7	2.2	1.5	-0.1	0.8
Exposure to tobacco smoke outside home	0.5	0.7	3.0	-1.3	1.0	-0.4	-0.1	-1.7	-0.5	-0.3	-0.7	-0.2	-0.8	-0.4
Medication for pain relief, constipation, heartburn	0.5	0.8	3.2	1.6	-0.9	-0.5	-0.7	0.1	-0.5	0.6	0.3	-0.5	-1.8	0.5
Medication: Omeprazole	0.5	0.6	2.9	-1.7	0.3	-0.5	-0.3	-1.3	-0.5	0.2	-1.1	-0.4	0.3	-0.3
Arm predicted mass (right)	0.5	2.5	6.0	-2.4	2.1	1.1	1.4	-2.5	1.2	0.7	2.0	1.3	0.1	0.7
Medication: Aspirin	0.5	0.6	3.6	-0.8	-0.7	0.2	0.1	-0.4	-0.0	-1.9	0.2	-0.1	-0.5	-1.2
Osteoporosis (self-reported)	0.5	0.6	4.4	-0.8	-0.0	0.3	0.4	-2.1	0.7	0.2	-0.6	0.3	0.5	0.7
Medication: Gliclazide	0.5	0.6	3.2	0.1	-0.2	-0.1	-0.1	-0.6	-0.5	-1.8	0.2	-0.4	0.9	-1.4
Illnesses of father: None of the above (group 1)	0.5	0.6	2.5	-0.5	1.5	0.2	0.3	0.7	0.1	0.9	0.3	0.4	1.6	-0.2
Average weekly champagne plus white wine intake	0.5	0.7	1.4	0.1	-0.3	-1.1	-1.2	-1.1	-1.0	-0.3	-0.8	-1.0	-0.2	-0.7
Mother’s age at death	0.5	0.6	3.5	0.4	1.1	0.5	0.3	1.9	0.2	-0.8	0.6	0.3	-0.2	0.1
Alcohol drinker status: Never	0.5	0.6	3.8	0.4	0.4	-0.3	-0.0	1.0	-0.3	-1.9	-0.8	-0.5	-0.7	-0.3
Arm fat-free mass (left)	0.5	2.5	6.2	-2.0	1.9	1.3	1.6	-2.5	1.4	0.8	2.2	1.4	-0.4	0.6
Age started oral contraceptive pill	0.5	0.6	1.2	-1.0	1.1	0.8	0.8	0.1	0.5	-0.2	-0.3	0.8	0.8	-1.1
Commuting to job workplace: Cycle	0.5	0.6	2.2	1.5	-1.1	0.2	0.1	-0.1	0.4	0.2	1.1	0.1	-0.4	1.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.5	-1.2	0.7	0.4	0.6	-1.1	0.6	1.2	-0.6	0.6	0.7	0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	-0.5	1.3	0.4	0.6	1.1	0.5	0.8	1.2	0.6	-0.3	0.4
Impedance of whole body	0.5	2.7	6.6	2.5	-2.6	-1.4	-1.9	1.4	-1.3	-0.1	-2.2	-1.5	-0.3	-0.9
Arm predicted mass (left)	0.5	2.6	5.9	-1.6	1.8	1.5	1.7	-2.4	1.6	0.8	2.3	1.6	-0.3	0.9
Alzheimer’s Disease (in mother)	0.4	0.5	1.5	-0.2	-1.2	-0.7	-0.9	-0.3	-0.1	1.2	-0.9	-0.3	0.2	0.5
Reaction Time	0.4	0.9	2.8	0.0	0.6	-1.0	-1.0	0.2	-1.2	-0.4	-0.4	-0.7	-1.7	-1.4
Primary Biliary Cirrhosis	0.4	0.5	1.4	0.7	0.6	0.8	0.8	-1.2	0.5	-0.1	0.4	0.8	0.5	-0.9
Hypothyroidism (self reported)	0.4	0.9	2.2	1.5	0.2	1.1	0.9	1.5	0.9	0.2	0.7	0.9	1.0	0.1
Lung FVC	0.4	1.8	6.0	-1.5	0.0	-1.6	-1.3	-1.8	-1.1	-0.7	-2.4	-1.1	-0.6	-1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	2.4	-0.6	-0.6	-0.6	-0.6	0.3	-0.4	-0.8	-1.5	-0.6	-0.7	0.8
Age when periods started (menarche)	0.4	1.1	2.6	-0.1	0.3	-1.2	-1.2	1.6	-1.2	0.8	-1.0	-1.1	1.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.6	1.3	-0.3	0.9	0.7	0.8	0.6	0.2	0.8	0.6	-0.1	-0.1
Impedance of leg (left)	0.4	1.7	5.5	2.1	-2.4	-0.9	-1.4	0.9	-0.8	0.5	-1.7	-1.0	0.6	-0.3
Past tobacco smoking	0.4	0.7	1.5	0.5	1.0	0.6	0.6	1.2	0.4	1.1	1.0	0.7	0.8	0.5
Medication: Ramipril	0.4	0.5	1.5	-0.2	-1.2	-0.2	-0.3	-0.2	0.1	-1.1	-0.6	-0.5	-1.2	0.1
Illnesses of siblings	0.4	0.6	2.5	-0.7	0.6	-0.2	-0.1	-0.2	-0.1	1.6	1.2	0.2	0.0	1.2
Arm fat percentage (right)	0.4	1.6	3.6	-0.3	-0.8	-1.1	-1.0	-1.7	-1.0	-1.7	-0.7	-1.1	-1.6	-1.9
Trunk fat-free mass	0.4	2.4	4.6	-1.9	1.9	1.2	1.6	-2.0	1.4	0.9	2.1	1.4	0.1	1.0
Hip circumference	0.4	1.9	4.8	-1.1	1.5	1.3	1.5	-2.2	1.3	0.1	1.9	1.4	-1.3	0.1
Father’s age at death	0.4	0.6	3.1	0.6	0.5	0.3	0.3	0.9	0.4	0.8	-0.4	0.5	1.8	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	3.3	-0.1	1.7	-0.6	-0.1	1.8	-0.3	-0.5	-0.5	-0.3	0.6	0.1
Mouth/teeth dental problems: Dentures	0.4	0.7	2.4	-0.0	-1.3	0.5	0.4	-1.0	1.0	-0.2	-0.6	0.2	-1.5	0.7
Illnesses of mother	0.4	0.5	1.8	0.0	-1.2	-0.6	-0.7	0.5	-0.5	0.3	0.4	-0.7	-1.4	-0.8
Trunk predicted mass	0.4	2.3	4.8	-1.9	1.9	1.2	1.6	-2.1	1.5	0.9	2.2	1.4	0.0	1.0
Medication: Paracetamol	0.4	0.6	3.1	-1.8	1.2	-0.1	0.1	0.5	-0.1	-0.5	-0.1	-0.1	0.2	-1.1
Number of full brothers	0.4	0.6	1.6	1.3	-0.9	-0.2	-0.3	-1.1	0.0	-0.5	-0.9	-0.4	1.1	0.2
Migraine (self-reported)	0.4	0.6	3.4	-0.2	0.6	0.3	0.3	1.1	-0.2	-0.7	0.2	0.1	1.8	-0.6
Mean time to correctly identify matches	0.4	0.8	2.1	-0.0	0.5	-1.0	-1.0	0.0	-1.1	-0.6	-1.0	-0.8	-1.1	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.3	-0.7	-0.5	-0.8	-0.5	0.9	-0.6	-0.4	-1.1	-0.5	-1.1	-0.4
Illnesses of father: Heart disease	0.4	0.6	1.4	-0.2	0.3	1.2	1.0	-0.4	1.0	0.7	-0.6	1.1	-0.0	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	4.2	-0.5	1.1	0.3	0.4	0.8	0.4	2.1	1.1	0.8	0.6	0.6
Whole body fat-free mass	0.4	2.0	4.0	-2.0	1.9	1.1	1.4	-1.9	1.2	0.7	2.0	1.3	-0.2	0.8
Arm fat percentage (left)	0.4	1.7	4.3	-0.5	-0.6	-1.1	-1.0	-1.8	-1.1	-1.8	-0.7	-1.1	-1.5	-2.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.0	0.3	1.0	-0.3	-0.1	1.1	-0.0	0.3	0.4	-0.2	1.4	0.8
Qualifications: nursing, teaching	0.4	0.6	1.9	0.2	-1.2	-0.8	-1.0	0.4	-0.8	-0.5	-1.4	-0.8	-0.1	-0.7
Asthma (self-reported)	0.4	0.9	3.8	-0.2	0.6	0.1	0.4	0.3	0.5	1.9	1.6	0.6	-1.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	5.2	2.3	0.8	0.1	0.2	-0.3	0.3	0.9	1.0	0.3	-1.5	0.2
Miserableness	0.4	0.7	1.8	-1.3	0.1	-1.2	-1.1	0.2	-1.1	-0.7	-0.6	-1.0	0.2	-0.5
Guilty feelings	0.4	0.7	2.2	-1.2	1.1	-0.4	-0.2	-0.1	-0.3	-1.1	0.3	-0.4	-1.5	-0.7
Illnesses of father: High blood pressure	0.4	0.5	1.3	0.2	-0.9	-1.0	-0.9	0.3	-0.9	-0.3	-0.8	-1.1	-0.6	-0.3
Risk taking	0.4	0.6	2.0	0.4	-0.6	1.0	0.7	-0.1	0.9	0.7	1.1	0.8	0.2	1.4
Unable to work because of sickness or disability	0.4	0.5	2.0	-1.3	0.3	-0.2	-0.1	1.4	-0.4	0.1	1.0	-0.1	-0.6	-0.4
Intelligence (Savage-Jansen 2018)	0.3	1.0	4.9	1.1	-0.5	0.6	0.6	2.2	0.6	-0.2	1.1	0.6	-1.2	0.3
Crohns Disease (2017)	0.3	0.7	2.4	1.2	-1.3	-0.4	-0.4	-1.0	-0.2	0.4	-1.0	-0.5	1.5	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.3	-0.1	-0.3	1.1	0.9	0.9	0.9	0.6	0.0	1.0	0.6	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.7	1.6	-1.5	0.3	0.1	1.5	0.5	0.3	1.0	0.4	-0.3	-0.0
Lupus	0.3	0.4	1.4	-1.1	-0.4	-0.4	-0.5	-0.6	-0.6	-0.5	-1.2	-0.6	0.3	-0.5
Blood White Count	0.3	2.2	7.3	-2.4	1.7	-1.3	-0.8	0.3	-1.2	-0.4	-1.2	-1.1	2.7	-1.2
BMI	0.3	1.5	4.0	-1.3	1.3	1.2	1.3	-1.7	1.1	0.1	2.0	1.1	0.1	0.3
Relative age of first facial hair	0.3	0.6	1.6	0.4	-1.2	0.1	-0.2	1.2	-0.2	-1.2	0.0	-0.5	1.2	0.0
Supplements: Zinc	0.3	0.3	1.1	-0.3	-1.1	-0.6	-0.7	0.0	-0.4	-0.4	-0.2	-0.7	0.6	-0.4
Severe depression (siblings)	0.3	0.4	1.0	1.0	-0.9	-0.4	-0.5	0.2	0.0	0.2	-0.5	-0.5	1.0	0.6
Trunk fat percentage	0.3	1.1	3.2	-0.2	-0.4	-0.5	-0.5	-1.6	-0.5	-1.3	-0.6	-0.5	-1.6	-1.8
Maternal smoking around birth	0.3	0.4	2.2	1.5	-0.4	-0.5	-0.6	-0.9	-0.2	0.2	-0.2	-0.3	0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.1	1.1	-0.6	0.9	0.5	0.8	0.8	0.7	1.4	0.9	-0.1	-0.0
Supplements: Glucosamine	0.3	0.4	1.4	0.8	0.9	0.3	0.3	1.2	0.4	0.7	-0.1	0.4	-0.4	0.5
Body mass index (BMI)	0.3	1.1	4.5	-1.2	0.9	0.5	0.7	-2.1	0.5	-0.8	1.3	0.6	-1.1	-0.6
Waist circumference	0.3	1.1	4.1	-0.8	0.5	0.8	0.9	-2.0	1.0	-0.5	1.2	0.8	-1.3	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.1	1.4	-1.3	0.8	0.4	0.3	0.6	0.5	1.1	0.7	0.2	-0.5
Qualifications: None of the above	0.3	0.6	1.0	-0.7	0.8	-1.0	-1.0	0.4	-1.0	-0.0	-0.8	-0.8	-0.6	-0.8
Pain all over the body in last month	0.3	0.3	0.9	-0.4	-0.2	-0.7	-0.5	-0.1	-0.5	-0.9	-0.7	-0.5	0.1	-0.6
Worrier / anxious feelings	0.3	0.6	5.6	0.5	-0.4	0.2	0.1	2.4	0.4	-0.2	0.0	0.0	-0.3	-0.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	3.7	0.1	-0.8	-0.7	-0.9	-0.7	-0.6	0.5	-0.7	-0.5	1.9	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	2.7	-0.9	1.6	0.2	0.3	-0.0	0.0	0.4	0.1	0.3	0.7	-0.1
Prospective memory result	0.3	0.3	1.3	-0.1	0.7	0.3	0.2	1.0	-0.3	-0.6	-0.2	0.1	-1.2	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	3.1	1.8	0.5	0.4	0.4	-0.9	0.8	1.7	0.3	0.7	0.2	0.6
Arm fat mass (right)	0.3	1.0	5.3	-0.9	-0.1	-0.4	-0.3	-2.3	-0.3	-1.1	0.2	-0.3	-1.4	-1.2
Birth weight of first child	0.3	0.5	1.1	-1.0	0.8	0.7	1.0	0.2	0.8	0.6	0.7	0.8	0.2	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	1.6	-0.5	-0.8	-0.7	-0.8	0.1	-0.6	-0.1	-1.2	-0.8	1.3	-0.0
Medication: Ventolin 100micrograms inhaler	0.3	0.3	2.0	-0.4	-1.0	0.2	0.1	0.2	0.2	0.3	-0.4	0.2	-1.4	-0.4
Body fat percentage	0.3	1.1	3.6	-0.5	-0.3	-0.5	-0.5	-1.9	-0.5	-1.3	-0.4	-0.5	-1.4	-1.8
Worry too long after embarrassment	0.3	0.5	3.0	-0.2	-0.1	-0.2	0.0	1.7	-0.1	-0.9	-0.2	-0.3	-1.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.6	0.4	-0.5	-0.2	-0.2	0.4	0.3	1.0	-0.8	0.0	1.3	0.9
Wheeze or whistling in the chest in last year	0.3	0.5	1.7	0.6	0.1	0.5	0.6	0.1	1.1	1.3	0.4	0.8	-0.4	0.6
Health satisfaction	0.3	0.4	1.1	-1.1	0.3	-0.8	-0.6	0.4	-0.9	-0.4	-0.6	-0.7	-0.0	-0.8
Qualifications: College or University degree	0.3	0.9	5.4	2.3	-1.8	-0.3	-0.6	0.6	-0.5	-0.3	-0.5	-0.4	0.3	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.6	0.7	-0.2	0.1	0.2	0.2	0.3	1.3	0.5	0.1	0.5	0.9
Medication for cholesterol	0.3	0.4	1.2	0.9	-0.1	-0.1	-0.2	1.1	0.1	0.8	-0.1	0.1	-0.9	0.8
Whole body water mass	0.3	1.8	4.0	-2.0	1.8	1.0	1.3	-1.8	1.1	0.5	1.8	1.1	-0.3	0.7
Arm fat mass (left)	0.3	1.1	5.0	-0.8	-0.0	-0.4	-0.2	-2.2	-0.3	-1.3	0.3	-0.3	-1.4	-1.4
Wears glasses or contact lenses	0.3	0.4	1.3	0.8	-0.7	0.3	0.0	0.3	0.0	-1.1	-1.0	-0.1	0.6	-0.5
Ever taken oral contraceptive pill	0.3	0.3	1.1	0.8	-0.6	-0.2	-0.3	-0.3	-0.0	1.0	-0.7	-0.2	0.2	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	-0.7	0.6	-0.3	-0.3	0.0	-0.4	-0.9	-0.7	-0.4	-0.1	-1.2
Ever smoked	0.3	0.5	1.2	-0.5	-1.1	-0.8	-0.7	-0.6	-0.4	-0.9	-1.1	-0.8	-0.3	-0.2
Basal metabolic rate	0.3	1.6	4.3	-1.9	1.6	0.8	1.1	-2.1	1.0	0.3	1.7	1.0	-0.5	0.5
Schizophrenia (2018)	0.2	0.3	1.2	0.3	0.0	-1.0	-1.1	-0.9	-0.8	0.0	0.0	0.0	0.0	0.0
Irritable Bowel Disease (IBD)	0.2	0.4	1.7	0.5	-1.3	0.3	0.2	0.2	0.3	0.4	-0.8	0.1	1.0	0.4
Age at First Birth	0.2	0.3	1.9	-1.4	0.3	-0.1	0.0	-0.5	-0.1	-0.1	0.0	-0.0	0.6	-0.4
Schizophrenia (2014)	0.2	0.4	1.2	1.1	0.0	-1.1	-1.0	-0.0	-0.9	0.0	0.0	0.0	0.0	0.0
Waist Hip Ratio (WHR)	0.2	0.8	3.9	1.1	-2.0	-0.7	-0.8	-0.7	-0.3	-0.3	0.5	-0.8	-0.7	-0.0
Systolic Blood Pressure	0.2	1.2	3.4	-0.4	-1.9	-1.1	-1.1	-1.0	-1.1	-1.3	-1.1	-1.4	-0.7	-0.2
Respiratory disease	0.2	0.4	2.4	0.0	0.1	-0.2	-0.0	0.1	-0.1	1.6	0.4	0.0	-1.1	-0.7
Sensitivity / hurt feelings	0.2	0.3	1.3	-0.5	-1.1	-0.2	-0.3	0.3	0.1	-0.5	-0.6	-0.5	0.4	-0.6
Hearing difficulty/problems: Yes	0.2	0.4	0.8	0.6	0.2	0.6	0.6	0.6	0.7	0.9	-0.4	0.7	0.3	0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.4	-0.8	-0.1	-0.3	-0.2	0.2	-0.2	-0.1	-1.2	-0.3	0.6	0.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	-0.4	0.4	-0.5	-0.4	-0.7	-0.9	-0.5	-0.1	-0.5	0.0	-0.4
Systolic blood pressure, automated reading	0.2	0.6	2.7	-0.7	-0.1	-0.7	-0.5	-0.1	-0.9	-1.7	-0.5	-0.9	-0.2	-0.5
Impedance of leg (right)	0.2	1.0	5.2	2.3	-1.6	-0.3	-0.7	1.0	-0.1	0.6	-1.0	-0.4	0.6	0.1
Leg fat-free mass (left)	0.2	1.2	4.0	-2.0	1.6	0.6	0.9	-1.5	0.7	0.0	1.3	0.8	-0.8	0.3
Stomach or abdominal pain in last month	0.2	0.3	1.1	-0.7	1.1	-0.0	0.2	-0.4	-0.1	-0.6	-0.8	-0.2	0.0	0.5
High blood pressure (mother)	0.2	0.3	1.7	0.4	0.1	0.2	0.3	-0.9	-0.1	-1.3	-0.6	0.1	0.1	0.5
Leg predicted mass (left)	0.2	1.2	3.8	-1.9	1.5	0.6	0.9	-1.5	0.6	0.0	1.4	0.8	-0.9	0.2
Trunk fat mass	0.2	1.0	3.7	-1.0	0.1	-0.2	-0.2	-1.9	-0.2	-1.2	-0.1	-0.2	-1.6	-1.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	1.2	-0.1	0.6	0.0	-0.1	-0.3	-0.1	0.6	0.5	0.0	0.6	-1.1
Weight	0.2	1.2	5.4	-1.5	1.1	0.6	0.8	-2.3	0.6	-0.4	1.2	0.7	-0.9	-0.4
Pulse rate	0.2	0.3	1.7	0.6	-1.3	-0.4	-0.6	0.2	-0.2	-0.4	0.3	-0.4	-0.5	-0.1
Noisy workplace	0.2	0.2	1.2	-0.6	1.1	-0.3	-0.3	0.5	-0.3	-0.2	0.4	-0.4	-0.5	0.3
Medication: Cholesterol lowering	0.2	0.3	1.4	0.4	-0.6	0.2	0.2	0.1	0.2	-1.2	0.2	-0.1	-0.8	-0.3
Lung cancer (father)	0.2	0.3	1.3	1.1	-0.3	-0.1	-0.3	-0.4	0.0	0.0	0.2	-0.1	1.0	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.3	0.3	-0.0	0.1	0.1	0.6	0.3	1.1	-0.2	0.3	0.6	1.1
Hair/balding pattern: Pattern 4	0.2	0.4	2.0	0.6	-1.0	0.3	0.3	0.5	0.0	-0.7	-1.4	0.0	0.3	0.1
Pulse wave reflection index	0.2	0.2	0.9	-0.0	1.0	0.2	0.3	-0.2	0.1	0.8	0.4	0.4	-0.2	0.1
Gout (self-reported)	0.2	0.3	0.9	-0.8	0.2	-0.0	-0.2	0.1	-0.0	0.0	-0.5	0.2	1.0	-0.9
Leg fat percentage (right)	0.2	0.7	4.3	-0.9	0.1	0.0	0.2	-2.1	0.3	-0.7	0.4	0.1	-0.9	-0.9
Medication: Ibuprofen	0.2	0.2	0.7	-0.8	0.6	-0.4	-0.3	-0.2	-0.6	-0.6	-0.2	-0.4	0.1	-0.4
Whole body fat mass	0.2	0.9	4.2	-0.9	0.1	-0.2	-0.1	-2.1	-0.1	-1.0	0.2	-0.1	-1.5	-1.2
Leg fat mass (right)	0.2	0.8	5.1	-1.2	0.3	0.2	0.3	-2.3	0.4	-0.6	0.7	0.2	-1.0	-0.6
Pulse rate, automated reading	0.2	0.7	1.4	0.3	0.4	1.0	0.9	-0.1	1.0	0.7	1.1	1.1	1.2	0.0
Comparative height size at age 10	0.2	0.9	2.4	-0.0	0.3	0.9	1.0	-1.5	1.1	0.4	0.9	1.0	-1.6	0.2
Chest pain or discomfort	0.2	0.3	1.3	0.4	0.2	-0.4	-0.4	0.1	-0.0	-0.6	-1.1	-0.5	-1.0	0.3
Leg fat-free mass (right)	0.2	0.9	3.9	-2.0	1.2	0.3	0.6	-1.4	0.3	0.0	1.0	0.5	-0.9	0.1
Leg predicted mass (right)	0.2	0.9	4.2	-2.0	1.2	0.2	0.5	-1.4	0.3	0.0	0.9	0.5	-0.8	0.1
Hearing aid user	0.2	0.2	1.6	-0.3	0.2	0.2	0.1	0.4	0.0	0.0	0.5	0.2	1.3	0.1
Medication: Bendroflumethiazide	0.2	0.3	1.8	-1.4	0.2	0.3	0.3	-0.8	0.0	-0.0	0.0	0.2	0.3	-0.2
Leg fat percentage (left)	0.2	0.7	4.0	-1.0	-0.2	-0.3	-0.2	-2.0	-0.1	-0.8	-0.1	-0.2	-0.9	-1.2
Average weekly beer plus cider intake	0.2	0.3	0.9	-0.7	-1.0	0.2	0.1	-0.4	0.2	0.1	0.8	0.2	0.9	0.1
Cholesterol lowering medication	0.2	0.3	1.4	-0.4	-0.1	0.6	0.4	-0.7	0.4	-0.4	0.3	0.4	1.2	-0.5
Supplements: Calcium	0.2	0.2	0.8	0.1	0.2	0.5	0.6	-0.3	0.5	-0.2	0.6	0.5	-0.9	0.4
Leg fat mass (left)	0.2	0.7	4.6	-1.1	0.1	0.1	0.2	-2.2	0.3	-0.6	0.5	0.2	-1.0	-0.7
Bipolar Disorder (2018)	0.1	0.1	1.1	1.1	0.0	0.0	-0.3	-0.2	-0.3	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.1	0.3	1.0	0.9	0.0	0.0	-0.9	-1.0	-0.9	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.7	0.0	0.0	0.0	-0.9	0.2	-0.8	0.0	0.0	0.0	0.0	0.0
Alzheimer’s Disease (including proxy)	0.1	0.2	0.9	-1.0	0.8	-0.2	-0.2	-0.5	0.1	0.3	0.2	0.0	-0.3	0.2
Rheumatoid Arthritis	0.1	0.1	1.0	-1.0	0.0	0.2	0.4	0.0	0.4	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	0.7	0.0	0.5	0.5	-0.0	0.3	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.1	1.1	7.0	0.6	0.7	0.0	0.5	0.3	0.1	0.4	1.8	0.4	-2.6	0.0
Smoking Status	0.1	0.3	1.9	-0.4	0.8	-0.1	0.2	0.2	0.1	0.6	1.4	0.1	0.1	0.6
Tanning	0.1	1.2	3.7	-1.5	-1.1	-1.1	-1.1	-0.0	-1.3	-0.3	-1.9	-1.2	-0.3	0.0
Forced vital capacity (FVC)	0.1	0.2	0.6	0.1	-0.2	-0.7	-0.6	-0.4	-0.3	0.7	-0.8	-0.4	0.3	-0.3
Mouth/teeth dental problems	0.1	0.2	0.5	0.2	0.7	0.0	0.3	0.4	-0.5	-0.2	0.5	0.3	0.7	-0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.4	1.0	0.2	-0.2	-0.1	-0.8	0.3	1.2	-0.1	0.1	0.5	0.4
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.6	-0.0	0.4	0.3	-0.5	0.2	-0.2	0.2	0.3	0.3	0.2
Peak expiratory flow (PEF)	0.1	0.3	1.6	1.3	-0.1	-0.2	-0.0	0.9	-0.0	0.3	0.3	-0.1	-0.5	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.6	0.4	0.4	0.1	-0.1	-0.8	0.2	0.5	-0.5	0.1	-0.2	0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.2	0.8	-0.1	0.4	0.1	1.1	0.4	0.3	0.0	0.3	0.6	-0.4
Birth weight	0.1	0.2	0.7	0.1	0.2	0.3	0.3	-0.3	0.2	0.5	0.8	0.3	0.4	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.2	0.9	1.0	-0.0	-0.1	-0.1	-0.4	0.2	0.8	-0.7	0.1	0.3	-0.2
Long-standing illness, disability or infirmity	0.1	0.1	0.4	0.2	-0.1	0.4	0.4	0.1	0.4	0.7	0.1	0.4	0.3	0.5
Back pain experienced in last month	0.1	0.2	0.5	0.1	0.2	-0.5	-0.6	-0.7	-0.3	-0.4	-0.1	-0.6	0.2	-0.6
Diastolic blood pressure, automated reading	0.1	0.3	1.3	-0.3	0.9	-0.0	0.1	-1.1	0.0	-0.2	0.4	0.1	-0.7	0.9
Major Depression (MDD)	0.0	0.0	0.1	0.2	0.0	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.1	0.0	0.0	0.0	-0.2	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.2	-0.1	0.0	0.5	0.3	0.1	0.3	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.4	1.7	-0.4	-1.1	-0.3	-0.3	-0.2	-0.1	-0.4	-1.3	-0.3	0.4	-0.3
Heel T-Score	0.0	0.3	1.2	-1.1	-0.5	-0.1	-0.1	-0.0	-0.2	-0.2	1.1	-0.2	-0.6	-0.4
Height	0.0	0.5	2.0	0.5	-0.5	0.8	0.5	-1.4	0.6	0.7	-0.2	0.6	0.7	0.4
Hair Pigment	0.0	0.7	1.8	0.3	-0.3	1.2	1.0	0.0	1.2	-0.1	0.8	1.1	-0.1	1.4
Sitting height	0.0	0.3	1.3	-1.1	0.2	-0.3	-0.3	-0.1	-0.5	-0.4	0.6	-0.3	0.4	-0.8
Standing height	0.0	0.2	0.7	-0.6	0.4	0.4	0.4	-0.5	0.5	0.9	0.1	0.4	0.1	0.5
High cholesterol (Self-reported)	0.0	0.1	0.3	-0.5	-0.1	0.3	0.2	-0.1	0.1	-0.1	0.1	0.1	-0.3	-0.5
Myopia	0.0	0.1	0.4	0.0	0.2	0.2	0.1	0.6	-0.1	-0.3	-0.2	0.1	-0.3	-0.3

Hub : Genes

P2RX1

Models

Trait associations