Hub : Genes

P2RY13

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.3330	0.1140	2.2e-03	0.093	NA	-0.007	NA	0.005	2.3e-03	NA	5.4e-01	NA	2.4e-01
2	NTR	Blood	0.0514	0.0137	4.8e-12	0.033	0.042	0.033	0.038	0.040	7.2e-11	2.3e-13	9.0e-11	2.8e-12	7.6e-13
3	YFS	Blood	0.1299	0.0224	0.0e+00	0.148	0.155	0.161	0.158	0.157	6.1e-46	2.4e-48	3.7e-50	2.0e-49	4.9e-49

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.4	0.3	-0.1	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.4	1.0	-0.3	-1.0	-0.4
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	0.5	-0.1	-0.8
Depression (Nagel 2018)	0.2	0.3	0.4	0.6	-0.1	-0.6
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.2	0.6	-1.8	-0.8
Neuroticism (Nagel 2018)	0.3	0.7	1.5	0.4	-1.2	-0.8
Schizophrenia (2018)	0.3	0.6	1.3	-0.6	-1.2	-0.0
Schizophrenia vs Biploar Disorder	0.8	1.1	1.7	1.0	-1.3	-0.8
Worry (Nagel 2018)	0.0	0.1	0.1	-0.3	-0.3	-0.2
Alzheimer’s Disease (in mother)	0.4	0.5	1.0	-0.4	1.0	0.5
Alzheimer’s Disease (in father)	2.1	2.3	2.7	-1.3	1.5	1.6
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	0.2	0.9	0.6
Crohns Disease (2017)	0.4	1.0	1.3	0.6	1.2	-1.1
Irritable Bowel Disease (IBD)	0.3	0.7	1.8	0.0	1.4	-0.4
Ulcerative Colitis (UC)	0.1	0.2	0.5	-0.0	0.7	0.2
Major Depression (MDD)	0.3	0.3	0.6	0.4	-0.4	-0.8
Reaction Time	0.2	0.3	0.5	0.5	-0.7	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	0.6	-0.8	-0.1
Breast Cancer	0.1	0.2	0.3	-0.5	-0.3	0.5
Ovarian Cancer	0.1	0.1	0.4	0.0	0.2	-0.6
Prostate Cancer	3.6	5.1	6.1	2.2	-2.1	-2.5
Age at First Birth	0.2	0.3	0.7	-0.2	-0.8	-0.5
Bipolar Disorder (2011)	1.8	1.7	2.9	1.2	-1.7	-0.9
Body Mass Index (BMI) (2010)	0.8	1.1	1.3	-1.2	0.9	1.1
Coronary Artery Disease (CAD)	2.6	3.1	5.9	-2.4	1.4	1.2
Crohns Disease (2012)	0.4	0.7	1.2	1.1	0.6	-0.6
Mean Putamen Volume	1.7	1.9	3.9	-1.3	2.0	0.2
Fasting Glucose	0.3	0.3	0.9	-0.0	-0.0	-1.0
HbA1C	0.3	0.4	0.7	-0.8	-0.3	-0.5
HDL Cholesterol	0.2	0.3	0.6	-0.1	0.8	0.5
LDL Cholesterol	0.3	0.5	0.9	-0.7	-0.1	1.0
Lupus	1.1	1.6	4.0	-0.8	2.0	0.3
Neuroticism (2016)	1.0	1.4	2.6	1.6	-0.8	-1.0
Primary Biliary Cirrhosis	1.3	1.9	3.5	1.4	-0.5	-1.9
Rheumatoid Arthritis	0.5	0.7	1.0	0.9	-1.0	-0.6
Schizophrenia (2014)	0.9	2.1	3.5	1.0	-1.9	-1.3
Triglycerides	3.5	5.7	9.8	1.9	-3.1	-1.9
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	-0.6	1.1	0.5
Ulcerative Colitis	0.0	0.0	0.1	0.2	-0.2	-0.2
Blood Eosinophil Count	0.9	6.9	11.8	2.0	-3.4	-2.2
Blood Platelet Count	0.1	0.8	2.5	-0.1	1.6	-0.1
Blood Red Count	0.4	3.6	5.1	2.2	-1.2	-2.1
Blood White Count	8.0	59.3	74.1	7.6	-6.8	-8.6
Heel T-Score	0.0	0.3	0.6	-0.8	-0.2	0.6
BMI	0.2	1.0	2.2	0.4	-1.5	-0.8
Height	0.0	0.8	2.0	0.6	1.4	0.2
Waist Hip Ratio (WHR)	0.2	0.7	1.0	1.0	-0.4	-1.0
Systolic Blood Pressure	0.2	1.2	1.6	0.9	-1.1	-1.3
Smoking Status	4.4	10.6	14.4	3.7	-2.0	-3.8
Allergy or Eczema	2.5	6.5	8.2	-2.2	2.9	2.6
Cardiovascular Disease	0.1	0.2	0.4	0.7	0.3	0.2
Hypothyroidism (self reported)	3.5	8.0	10.6	-2.7	2.5	3.2
Respiratory disease	1.4	3.0	3.6	-1.9	1.4	1.9
Type 2 Diabetes (T2D) (2018)	0.8	1.5	1.6	1.3	-1.3	-1.2
Lung FEV1/FVC ratio	0.3	1.3	1.7	1.1	-1.3	-0.9
Lung FVC	0.1	0.5	0.8	-0.9	-0.3	0.8
Neuroticism	0.2	0.5	1.0	-1.0	0.4	0.7
Chronotype (morning person)	0.7	1.5	2.4	1.2	-1.6	-0.8
Hair Pigment	0.3	7.8	12.0	2.7	-3.5	-2.0
Tanning	0.0	0.2	0.4	-0.1	0.7	-0.2
Hand grip strength (left)	1.3	3.4	5.0	-1.6	1.6	2.2
Number of treatments/medications taken	0.6	1.0	1.5	-1.2	0.9	0.8
Average weekly spirits intake	1.9	2.3	3.2	0.9	-1.8	-1.7
Sensitivity / hurt feelings	0.2	0.4	0.9	0.4	-1.0	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.2	0.3	-0.5
Hearing difficulty/problems: Yes	0.2	0.3	0.8	0.4	0.2	-0.9
Relative age of first facial hair	0.1	0.2	0.4	-0.6	-0.4	-0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-0.2	-0.9	0.6
Ever used hormone-replacement therapy (HRT)	2.0	2.5	4.4	1.4	-1.1	-2.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.4	-0.4	-1.2	-0.4
Systolic blood pressure, automated reading	0.5	1.3	1.9	1.0	-1.4	-1.0
Eye problems/disorders: Diabetes related eye disease	3.0	3.3	4.5	2.1	-2.1	-1.0
Angina	0.5	0.6	0.7	0.8	-0.8	-0.7
Medication for hormone replacement therapy	4.6	5.1	6.4	1.8	-2.4	-2.5
Vitamin and mineral supplements	0.3	0.4	0.8	-0.1	0.9	0.7
Supplements: Zinc	1.2	1.3	1.9	-1.2	1.4	0.7
Medication: Co-codamol	0.3	0.3	0.5	-0.7	0.6	0.4
Medication: Metformin	1.0	1.5	3.1	1.8	-0.8	-0.8
Diabetes (father)	0.0	0.0	0.0	0.1	-0.1	-0.0
Diabetes (mother)	1.0	1.3	2.1	0.8	-1.5	-1.0
Severe depression (siblings)	1.2	1.3	1.5	1.2	-1.0	-1.2
Pack years adult smoking proportion	1.0	1.5	2.3	1.1	-1.5	-0.9
Impedance of leg (right)	0.0	0.0	0.1	-0.1	0.3	-0.0
Leg fat-free mass (left)	0.0	0.2	0.6	0.7	-0.1	0.1
Trunk fat percentage	0.7	2.8	4.8	1.5	-2.2	-1.1
Hand grip strength (right)	1.5	4.0	4.7	-1.6	2.1	2.2
Townsend deprivation index at recruitment	0.5	0.7	1.9	0.1	-0.3	-1.4
Current tobacco smoking	5.8	9.5	11.8	3.3	-2.5	-3.4
Average weekly fortified wine intake	0.3	0.3	0.5	0.3	0.6	0.7
Maternal smoking around birth	2.8	4.1	5.4	2.0	-1.8	-2.3
Fed-up feelings	0.3	0.5	1.0	0.8	-0.2	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	0.9	1.0	0.1	-0.9
Relative age voice broke	0.3	0.4	0.5	-0.7	0.5	0.7
Taking other prescription medications	0.6	0.9	1.1	-1.1	1.0	0.8
Age when periods started (menarche)	0.1	0.3	0.5	-0.2	0.7	0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.7	0.9	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	0.5	0.1	0.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.3	0.1	-1.1	-1.0
Qualifications: CSEs or equivalent	0.1	0.2	0.6	0.7	0.1	-0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.4	0.1	0.4
High blood pressure	0.4	1.0	1.6	1.3	-0.9	-0.8
Hayfever, allergic rhinitis or eczema	1.1	2.4	4.3	-0.9	2.1	1.4
Multivitamins +/- minerals	0.7	0.9	1.9	0.6	-0.5	-1.4
Stomach or abdominal pain in last month	4.1	5.0	6.1	-2.2	2.5	2.0
Supplements: Glucosamine	0.8	1.0	1.6	0.9	-0.8	-1.3
Diverticular disease/diverticulitis (self-reported)	3.4	4.0	7.3	-1.8	2.7	1.2
Medication: Atenolol	0.4	0.5	0.8	-0.7	0.9	0.3
Medication: Levothyroxine sodium	3.0	5.0	5.2	-2.2	2.3	2.3
Sitting height	0.1	0.8	1.7	-0.1	0.8	1.3
Chronic bronchitis/emphysema (father)	0.1	0.2	0.4	0.2	0.1	-0.6
High blood pressure (mother)	0.3	0.4	0.8	0.5	-0.5	-0.9
Body mass index (BMI)	0.1	0.6	1.2	0.5	-1.1	-0.5
Impedance of leg (left)	0.0	0.1	0.1	0.2	0.2	-0.2
Leg predicted mass (left)	0.0	0.2	0.6	0.8	-0.1	0.1
Trunk fat mass	0.4	1.8	2.9	1.4	-1.7	-0.8
Waist circumference	0.4	1.4	1.9	1.1	-1.4	-1.1
Number of incorrect matches in round	0.6	1.0	1.6	-1.0	1.3	0.6
Past tobacco smoking	1.2	2.2	4.4	-1.4	0.4	2.1
Alcohol usually taken with meals	0.2	0.4	0.5	0.7	-0.5	-0.5
Nervous feelings	0.2	0.5	0.9	-1.0	0.3	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	1.8	0.9	-1.0	-1.3
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.1	-0.1	-0.7
Hair/balding pattern: Pattern 2	3.5	4.5	5.4	2.3	-1.7	-2.2
Had menopause	0.2	0.2	0.6	-0.8	0.3	0.0
Had other major operations	1.2	1.5	2.0	1.4	-1.1	-1.1
Forced vital capacity (FVC)	0.2	0.7	1.3	-0.7	0.5	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.1	-0.1	0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.3	-0.4	-0.4
Qualifications: None of the above	1.0	2.0	3.7	0.8	-1.3	-1.9
Financial difficulties in last 2 years	0.4	0.5	1.2	0.5	-0.2	-1.1
Mouth/teeth dental problems	1.6	2.5	3.3	-1.5	1.4	1.8
Heart attack	0.3	0.4	0.6	-0.8	0.2	0.6
Allergy	0.5	1.2	2.7	0.5	-1.7	-0.8
Pain all over the body in last month	2.0	2.2	3.3	1.8	-0.9	-1.6
Diabetes (self-reported)	1.9	2.9	4.1	2.0	-1.4	-1.6
Hayfever/allergic rhinitis (self-reported)	5.6	7.4	9.6	-2.3	3.1	2.7
Medication: Ramipril	0.1	0.1	0.2	0.5	-0.1	-0.1
Medication: Simvastatin	0.0	0.0	0.1	-0.1	-0.1	0.2
Fluid intelligence score	0.1	0.2	0.4	0.0	0.4	0.6
Illnesses of siblings	0.8	1.1	1.6	-1.2	1.3	0.3
Neuroticism score	0.0	0.0	0.1	-0.3	0.0	-0.1
Weight	0.0	0.2	0.4	0.6	-0.4	-0.0
Impedance of arm (right)	0.1	0.6	1.2	0.7	-1.1	-0.3
Arm fat percentage (right)	0.5	1.9	4.0	1.1	-2.0	-0.7
Trunk fat-free mass	0.2	0.9	1.9	0.0	1.4	1.0
Hip circumference	0.1	0.2	0.6	0.1	-0.8	0.3
Time employed in main current job	0.8	0.9	0.9	-0.9	1.0	0.9
Alcohol intake versus 10 years previously	0.5	0.7	1.3	0.9	-0.2	-1.1
Father’s age at death	1.1	1.5	3.8	2.0	-0.3	-0.7
Worrier / anxious feelings	0.0	0.0	0.1	0.3	-0.1	-0.0
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	4.6	2.1	-1.5	-1.7
Falls in the last year	0.1	0.1	0.2	0.3	0.2	-0.5
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	-0.1	-0.3	-0.3
Number of live births	2.7	3.8	5.3	-1.3	2.3	2.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	1.7	-1.0	0.9	1.3
Pulse rate	0.0	0.1	0.1	0.3	-0.3	-0.1
Happiness	0.1	0.2	0.4	0.7	0.2	0.1
Noisy workplace	0.3	0.3	0.4	0.4	-0.6	-0.7
Qualifications: A levels/AS levels or equivalent	1.4	3.0	3.8	-1.9	1.2	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	0.9	-0.1	-0.8
Mouth/teeth dental problems: Dentures	1.4	2.4	2.9	1.3	-1.7	-1.6
Asthma	0.0	0.0	0.0	0.0	0.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.1	-0.5	-0.4
Medication: Cholesterol lowering	0.7	1.1	1.8	-0.9	1.3	0.9
Depression (self-reported)	0.7	0.8	0.9	-0.8	1.0	1.0
Medication: Lansoprazole	1.2	1.4	3.3	-0.8	1.8	0.5
Prospective memory result	1.6	1.9	2.9	1.6	-0.6	-1.7
Lung cancer (father)	0.3	0.3	0.6	-0.8	-0.4	-0.5
Illnesses of mother	0.6	0.8	1.9	-0.6	-0.1	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.1	-0.6	0.4	1.0
Pulse wave Arterial Stiffness index	0.6	0.7	0.9	-0.7	0.7	1.0
Impedance of arm (left)	0.1	0.7	1.1	0.7	-1.1	-0.7
Arm fat mass (right)	0.3	1.4	2.4	1.2	-1.5	-0.6
Trunk predicted mass	0.2	1.0	1.9	-0.0	1.4	1.0
Standing height	0.1	1.0	2.0	0.6	1.4	0.7
Length of working week for main job	1.6	1.8	3.1	1.1	-1.8	-1.0
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.1	0.3	-0.3
Breastfed as a baby	1.0	1.2	1.6	-1.3	0.9	1.1
Tense / ‘highly strung’	1.0	1.6	1.9	1.1	-1.3	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.0	0.4	0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.2	-0.4	-0.3
Birth weight of first child	2.1	3.9	7.1	2.7	-1.0	-1.9
Peak expiratory flow (PEF)	1.1	2.5	3.6	-1.5	1.9	1.4
Pulse wave reflection index	1.8	2.2	3.0	-1.7	1.0	1.7
Ever highly irritable/argumentative for 2 days	1.4	1.6	2.8	1.1	-1.7	-0.9
Loud music exposure frequency	1.8	2.0	2.7	1.5	-1.0	-1.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.8	0.9	-0.3	-0.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.6	1.3	-1.1	-0.8
Blood clot in the leg (DVT)	0.0	0.0	0.1	-0.1	-0.0	-0.3
Medication: Paracetamol	0.1	0.2	0.5	-0.7	0.3	-0.0
Headache pain in last month	0.1	0.1	0.3	0.1	0.1	-0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	0.0	-0.1	-0.5
Glaucoma (self-reported)	0.1	0.1	0.2	0.4	0.4	-0.1
Gout (self-reported)	1.9	2.6	3.2	1.3	-1.8	-1.7
Hypothyroidism/myxoedema (self-reported)	2.5	4.8	5.8	-2.3	1.9	2.4
Medication: Amlodipine	0.7	1.0	1.7	-0.9	1.3	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.6	0.3	0.1
Birth weight	0.2	0.3	0.9	0.2	0.9	-0.3
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.5	1.2	-0.1	-1.2
High blood pressure (siblings)	2.2	3.2	4.9	1.8	-2.2	-1.2
Forced vital capacity (FVC), Best measure	0.2	0.9	1.5	-0.6	0.8	1.2
Body fat percentage	0.5	2.0	3.8	1.2	-1.9	-0.9
Leg fat percentage (right)	0.1	0.4	1.0	0.3	-1.0	-0.4
Arm fat-free mass (right)	0.1	0.4	0.6	0.4	0.8	0.5
Exposure to tobacco smoke outside home	0.4	0.5	1.4	0.2	0.2	-1.2
Comparative body size at age 10	0.3	0.9	1.9	-0.7	-0.6	1.4
Number of full brothers	0.3	0.3	0.5	0.1	-0.7	-0.7
Worry too long after embarrassment	0.5	0.9	1.3	-1.1	0.2	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.7	0.1	-0.4
Wheeze or whistling in the chest in last year	2.2	4.0	5.8	2.0	-1.6	-2.4
Number of children fathered	0.9	1.0	1.4	0.5	-1.1	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.3	0.5	0.3
Age at first live birth	0.3	0.5	0.9	-0.4	0.9	0.7
Pulse wave peak to peak time	0.6	0.7	0.9	0.9	-0.6	-1.0
Health satisfaction	0.1	0.1	0.2	0.2	0.4	-0.1
Shortness of breath walking on level ground	0.1	0.2	0.4	0.6	-0.3	-0.1
Qualifications: College or University degree	0.4	1.2	2.0	-1.1	0.6	1.4
Eye problems/disorders: None of the above	2.3	2.6	4.0	-1.8	2.0	0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.4	0.2	-0.4
Emphysema/chronic bronchitis	0.2	0.2	0.3	-0.5	0.4	0.5
Medication for pain relief, constipation, heartburn	0.6	1.0	1.5	1.2	-1.2	-0.4
Neck or shoulder pain in last month	0.2	0.2	0.4	0.4	-0.7	-0.4
Medication: Blood pressure	0.0	0.1	0.2	0.1	0.2	0.4
Angina (self-reported)	1.4	1.9	1.9	1.4	-1.4	-1.4
Migraine (self-reported)	2.0	2.5	3.9	-2.0	1.4	1.2
Medication: Ibuprofen	0.1	0.1	0.1	-0.3	-0.4	-0.1
Medication: Allopurinol	1.9	2.6	4.7	1.3	-1.1	-2.2
Medication: Omeprazole	0.0	0.0	0.1	0.0	0.3	-0.2
Medication: Seretide 50 evohaler	1.7	1.9	3.0	-1.2	1.2	1.7
Mean time to correctly identify matches	0.6	1.2	2.3	0.7	-1.5	-0.9
Heart disease (mother)	0.1	0.2	0.4	0.2	0.6	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.4	-0.4	-0.6	-0.6
Whole body fat mass	0.4	1.7	2.8	1.3	-1.7	-0.8
Leg fat mass (right)	0.2	0.8	1.4	0.8	-1.2	-0.6
Arm predicted mass (right)	0.0	0.2	0.4	0.6	0.5	0.3
Pulse rate, automated reading	0.8	2.7	4.1	1.6	-2.0	-1.2
Alcohol intake frequency.	0.2	0.5	0.7	0.8	-0.4	-0.9
Comparative height size at age 10	0.1	0.3	0.7	0.5	0.8	0.2
Number of full sisters	0.5	0.6	1.3	-0.4	1.1	0.5
Suffer from ‘nerves’	0.1	0.2	0.3	-0.4	-0.5	0.2
Overall health rating	0.0	0.0	0.1	0.0	-0.3	-0.2
Chest pain or discomfort	0.2	0.3	0.5	0.6	0.1	-0.7
Had major operations	0.1	0.1	0.1	0.3	0.3	-0.3
Age at last live birth	2.3	3.3	7.0	-1.0	2.6	1.4
Family relationship satisfaction	0.2	0.3	0.7	0.8	0.2	0.0
Leg pain on walking	0.6	0.8	1.7	0.9	-1.3	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.3	0.2	-0.4
Commuting to job workplace: Car/motor vehicle	4.9	5.6	7.0	2.6	-2.0	-2.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	0.4	-1.1	-0.1
Medication: Aspirin	0.8	1.0	1.4	-0.9	0.9	1.2
Supplements: Vitamin C	0.0	0.0	0.0	-0.0	-0.1	-0.0
Knee pain experienced in last month	0.1	0.1	0.2	0.1	-0.2	-0.5
Hypertension (Self-reported)	0.2	0.4	0.8	0.9	-0.6	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	3.9	-0.8	2.0	0.7
Illnesses of father: Heart disease	0.2	0.3	0.8	-0.9	-0.3	0.4
Illnesses of siblings: Diabetes	1.0	1.2	2.4	-1.1	0.4	1.6
Smoking status: Previous	0.6	0.9	2.2	0.7	-0.4	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.1	1.5	-1.0	-0.3
Whole body fat-free mass	0.1	0.4	0.6	0.4	0.8	0.6
Leg fat-free mass (right)	0.1	0.3	0.8	0.9	0.0	0.1
Arm fat percentage (left)	0.5	2.1	4.2	1.2	-2.0	-1.0
Average weekly red wine intake	0.6	1.0	1.8	-0.6	0.8	1.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.1	0.7	-1.4	-0.8
Mood swings	0.7	1.3	1.7	1.3	-0.6	-1.3
Loneliness, isolation	1.7	2.4	3.3	1.3	-1.8	-1.5
Long-standing illness, disability or infirmity	1.3	1.9	2.8	-1.7	1.2	1.3
Ever had bowel cancer screening	0.0	0.0	0.0	-0.2	-0.1	-0.1
Diabetes diagnosed by doctor	1.0	1.6	2.4	1.6	-1.2	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	0.9	-0.3	0.8	1.0
Friendships satisfaction	0.4	0.5	0.9	0.8	-1.0	0.0
Qualifications: nursing, teaching	0.2	0.4	0.8	-0.1	-0.6	0.9
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.4	0.6	0.3
Eye problems/disorders: Cataract	1.8	2.1	3.4	1.3	-1.8	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.6	1.1	-0.6	-1.6
Medication for cholesterol	2.5	3.9	5.3	-1.4	2.3	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.2	3.7	5.2	-2.3	1.5	1.9
Back pain experienced in last month	0.5	0.7	1.4	0.7	-1.2	-0.6
Mineral and other dietary supplements	1.4	1.9	2.5	-1.2	1.3	1.6
Breast cancer (self-reported)	0.2	0.2	0.4	-0.6	0.5	-0.1
Asthma (self-reported)	0.0	0.0	0.1	0.1	0.2	0.3
Osteoporosis (self-reported)	0.2	0.3	0.5	0.7	-0.3	-0.5
Osteoarthritis (self-reported)	1.0	1.3	2.0	1.2	-0.6	-1.4
Medication: Aspirin	0.3	0.4	0.9	-0.3	0.5	0.9
Medication: Gliclazide	1.3	1.4	2.9	1.0	-1.7	-0.6
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.1	-0.4	-0.2
Smoking status: Current	4.0	6.4	8.0	2.8	-1.9	-2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.0	-0.2	-1.4	0.2
Whole body water mass	0.1	0.4	0.6	0.4	0.8	0.7
Leg predicted mass (right)	0.1	0.3	0.9	0.9	-0.0	0.1
Arm fat mass (left)	0.3	1.2	2.2	1.1	-1.5	-0.5
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.3	0.4	0.1
Average weekly champagne plus white wine intake	0.8	1.1	1.4	-1.2	0.9	1.0
Miserableness	0.5	0.9	1.6	-0.6	1.3	0.9
Guilty feelings	0.5	0.7	1.0	0.9	-0.7	-1.0
Wears glasses or contact lenses	2.0	2.4	3.7	1.0	-1.5	-1.9
Ever taken oral contraceptive pill	0.0	0.0	0.0	-0.2	0.1	0.2
Hearing aid user	1.6	1.8	2.8	-1.5	0.7	1.7
Mother’s age at death	0.1	0.1	0.3	0.3	-0.5	-0.1
Financial situation satisfaction	1.8	2.2	3.6	-1.6	1.9	0.8
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.4	-0.4	-0.2
Commuting to job workplace: Public transport	0.8	1.0	1.4	-1.2	0.9	0.9
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	0.4	0.1	0.3
Medication: Blood pressure	0.7	1.4	2.4	0.7	-1.6	-1.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.4	-0.3	-0.5	0.6
Supplements: Fish oil (including cod liver oil)	2.1	2.7	2.9	1.7	-1.6	-1.7
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.2	0.4	0.4
Medication: Bendroflumethiazide	0.0	0.1	0.1	-0.3	-0.2	0.2
Medication: Paracetamol	0.2	0.4	0.8	-0.9	0.5	0.0
Medication: Lisinopril	3.4	4.4	7.9	2.1	-1.0	-2.8
Medication: Atorvastatin	0.8	1.0	1.6	-1.1	1.3	0.2
Illnesses of father: High blood pressure	3.8	4.6	5.9	-1.8	2.2	2.4
Alcohol drinker status: Never	0.4	0.5	0.9	0.8	-1.0	0.2
Ever smoked	3.8	6.7	10.6	2.8	-1.3	-3.3
Basal metabolic rate	0.0	0.2	0.3	0.6	0.4	0.4
Leg fat percentage (left)	0.2	0.8	1.4	0.7	-1.2	-0.7
Arm fat-free mass (left)	0.1	0.4	0.6	0.2	0.6	0.8
Number of operations (self-reported)	0.0	0.0	0.0	0.2	0.1	0.1
Average weekly beer plus cider intake	2.0	2.8	4.2	1.6	-1.3	-2.1
Irritability	0.0	0.1	0.1	0.2	-0.4	-0.1
Risk taking	0.9	1.4	2.0	1.4	-0.9	-1.2
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	0.2	0.2	0.2
Fractured/broken bones in last 5 years	0.5	0.6	1.0	0.5	-1.0	-0.7
Age started oral contraceptive pill	4.3	5.3	7.1	-2.7	1.8	2.4
Diastolic blood pressure, automated reading	0.1	0.4	1.1	0.5	-1.0	-0.1
Ever depressed for a whole week	0.1	0.1	0.3	-0.6	0.1	0.2
Unable to work because of sickness or disability	4.4	5.7	6.0	2.3	-2.5	-2.4
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.3	-0.7	-0.2
Myopia	1.5	2.2	3.1	1.6	-1.0	-1.8
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	-1.0	0.6	0.3
Cholesterol lowering medication	0.6	0.8	1.1	0.8	-0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	-0.1	0.6	0.1
Pain experienced in last month	0.0	0.1	0.1	-0.1	-0.3	0.3
Supplements: Calcium	0.5	0.5	1.0	1.0	0.2	-0.7
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	0.0	0.0	0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.1	-1.0	0.4	0.9
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	0.1	-0.2	-0.6
Heart disease (siblings)	0.1	0.1	0.2	0.2	0.4	-0.4
Alcohol drinker status: Previous	0.7	0.8	1.7	0.7	-0.4	-1.3
Pack years of smoking	1.3	2.0	2.9	1.3	-1.7	-1.1
Impedance of whole body	0.1	0.4	0.5	0.6	-0.7	-0.6
Leg fat mass (left)	0.3	1.0	1.6	1.0	-1.2	-0.7
Arm predicted mass (left)	0.1	0.3	0.4	0.3	0.6	0.7