Hub : Genes

PABPC4L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Pheochromocytoma and Paraganglioma	0.068	0.046	0.00790	0.007	0.015	0.006	NA	0.018	0.1700	8e-02	0.19000	NA	0.06200
2	TCGA	Thyroid Carcinoma	0.029	0.017	0.00063	0.035	0.030	0.029	NA	0.029	0.0002	6e-04	0.00072	NA	0.00071

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder (2018)	0.6	1.0	1.1	-0.9	1.0
Bipolar Disorder or Schizophrenia	0.2	0.6	0.6	-0.8	0.8
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.3	0.5
Depression (Nagel 2018)	0.0	0.1	0.1	0.2	-0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.8	-0.7	0.9
Neuroticism (Nagel 2018)	0.1	0.2	0.3	0.6	-0.4
Schizophrenia (2018)	0.0	0.0	0.1	-0.3	0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	-0.0	-0.3
Worry (Nagel 2018)	0.1	0.2	0.2	-0.3	0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.4	0.2
Alzheimer’s Disease (in father)	0.8	0.8	1.1	-1.0	0.8
Alzheimer’s Disease (including proxy)	0.8	1.1	1.3	-1.2	0.9
Crohns Disease (2017)	0.0	0.0	0.0	-0.2	0.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.3	-0.5	0.5
Ulcerative Colitis (UC)	0.1	0.1	0.2	-0.2	0.4
Major Depression (MDD)	0.1	0.1	0.1	0.3	-0.3
Reaction Time	1.6	3.0	3.2	-1.7	1.8
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.2	0.5	-0.4
Breast Cancer	0.1	0.3	0.4	0.6	-0.5
Ovarian Cancer	1.0	1.4	2.0	1.4	-0.9
Prostate Cancer	0.1	0.1	0.2	0.4	-0.3
Age at First Birth	0.1	0.1	0.2	-0.2	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.1	0.1
Body Mass Index (BMI) (2010)	1.4	1.9	2.1	1.3	-1.4
Coronary Artery Disease (CAD)	0.3	0.3	0.5	0.3	-0.7
Crohns Disease (2012)	1.0	1.6	1.7	1.3	-1.2
Mean Putamen Volume	0.0	0.0	0.0	0.1	-0.2
Fasting Glucose	0.0	0.1	0.1	-0.3	0.1
HbA1C	0.1	0.1	0.2	0.4	-0.0
HDL Cholesterol	0.4	0.7	0.7	-0.8	0.9
LDL Cholesterol	0.2	0.3	0.4	0.6	-0.5
Lupus	0.3	0.4	0.6	0.4	-0.8
Neuroticism (2016)	0.3	0.5	0.7	-0.5	0.8
Primary Biliary Cirrhosis	0.3	0.4	0.5	-0.6	0.7
Rheumatoid Arthritis	0.3	0.4	0.4	-0.6	0.6
Schizophrenia (2014)	0.0	0.0	0.0	0.0	-0.2
Triglycerides	0.2	0.3	0.4	-0.6	0.5
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.2	1.8	-1.2
Ulcerative Colitis	0.3	0.4	0.5	-0.5	0.7
Blood Eosinophil Count	0.0	0.1	0.2	-0.4	0.2
Blood Platelet Count	0.0	0.0	0.0	0.1	-0.0
Blood Red Count	0.4	3.4	3.6	1.8	-1.9
Blood White Count	0.1	0.6	0.7	-0.7	0.8
Heel T-Score	0.6	4.9	5.1	-2.3	2.2
BMI	0.7	3.9	4.4	1.8	-2.1
Height	1.5	29.2	30.2	5.5	-5.3
Waist Hip Ratio (WHR)	0.6	2.9	3.3	1.6	-1.8
Systolic Blood Pressure	2.0	9.9	10.0	-3.1	3.2
Smoking Status	0.1	0.2	0.2	-0.5	0.4
Allergy or Eczema	0.2	0.5	0.7	-0.6	0.8
Cardiovascular Disease	0.0	0.1	0.2	-0.5	0.3
Hypothyroidism (self reported)	0.3	0.7	0.8	-0.8	0.9
Respiratory disease	0.9	1.9	2.0	-1.3	1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.7	-0.7	0.8
Lung FEV1/FVC ratio	3.5	17.8	19.6	-4.4	4.0
Lung FVC	0.5	2.3	2.5	1.5	-1.6
Neuroticism	0.1	0.2	0.2	0.4	-0.4
Chronotype (morning person)	0.7	1.6	1.7	1.2	-1.3
Hair Pigment	0.1	1.4	1.8	1.0	-1.3
Tanning	0.4	4.7	4.9	2.1	-2.2
Hand grip strength (left)	1.2	3.3	4.2	1.5	-2.0
Number of treatments/medications taken	1.7	3.0	3.1	-1.7	1.8
Average weekly spirits intake	0.0	0.0	0.0	-0.2	-0.0
Sensitivity / hurt feelings	0.3	0.6	0.6	0.7	-0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.3	0.5	-0.6
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.0	-0.0
Relative age of first facial hair	0.2	0.3	0.4	0.6	-0.5
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	2.5	-1.4	1.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	-0.3	0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.3	-0.3
Systolic blood pressure, automated reading	2.6	7.6	8.1	-2.7	2.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.1	-1.0	1.0
Angina	1.0	1.2	1.3	-1.1	1.1
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.1	-0.0
Vitamin and mineral supplements	0.6	0.9	0.9	0.9	-0.9
Supplements: Zinc	0.0	0.0	0.0	-0.0	0.2
Medication: Co-codamol	0.0	0.0	0.1	0.2	-0.2
Medication: Metformin	0.1	0.1	0.2	0.4	-0.1
Diabetes (father)	0.5	0.6	0.6	-0.8	0.8
Diabetes (mother)	0.0	0.0	0.0	-0.1	-0.2
Severe depression (siblings)	0.0	0.0	0.0	-0.0	0.0
Pack years adult smoking proportion	0.2	0.3	0.3	0.5	-0.5
Impedance of leg (right)	0.1	0.7	0.8	-0.8	0.9
Leg fat-free mass (left)	3.2	17.0	18.1	4.0	-4.3
Trunk fat percentage	1.4	5.6	6.0	2.3	-2.4
Hand grip strength (right)	1.3	3.4	4.5	1.5	-2.1
Townsend deprivation index at recruitment	0.4	0.6	1.0	1.0	-0.4
Current tobacco smoking	1.2	2.0	2.2	-1.5	1.4
Average weekly fortified wine intake	2.1	2.5	2.6	-1.6	1.5
Maternal smoking around birth	0.2	0.3	0.4	-0.6	0.4
Fed-up feelings	0.0	0.1	0.1	0.3	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	1.5	1.1	-1.2
Relative age voice broke	0.4	0.6	0.6	0.8	-0.7
Taking other prescription medications	0.5	0.7	0.8	-0.9	0.8
Age when periods started (menarche)	0.1	0.2	0.3	-0.5	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.5	0.6	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.0	0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	1.5	-1.2	0.8
Qualifications: CSEs or equivalent	1.7	2.2	2.5	-1.6	1.4
Serious illness, injury or assault to yourself	0.6	0.8	0.9	-1.0	0.8
High blood pressure	0.0	0.1	0.2	-0.3	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.4	-0.5	0.6
Multivitamins +/- minerals	0.3	0.4	0.5	-0.7	0.6
Stomach or abdominal pain in last month	0.1	0.2	0.2	-0.4	0.4
Supplements: Glucosamine	2.6	3.4	3.8	-1.9	1.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.0	1.0	-0.8
Medication: Atenolol	0.0	0.0	0.0	-0.0	-0.1
Medication: Levothyroxine sodium	0.4	0.6	0.8	-0.6	0.9
Sitting height	1.6	11.0	12.1	3.1	-3.5
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	-0.1	-0.1
High blood pressure (mother)	0.0	0.1	0.1	0.3	-0.1
Body mass index (BMI)	1.0	4.3	4.8	1.9	-2.2
Impedance of leg (left)	0.1	0.3	0.3	-0.4	0.6
Leg predicted mass (left)	3.3	17.5	18.7	4.0	-4.3
Trunk fat mass	2.4	10.3	11.0	3.1	-3.3
Waist circumference	2.7	10.0	10.4	3.1	-3.2
Number of incorrect matches in round	0.0	0.1	0.1	0.0	-0.4
Past tobacco smoking	1.8	3.3	3.7	-1.7	1.9
Alcohol usually taken with meals	0.1	0.1	0.2	0.5	-0.3
Nervous feelings	0.9	1.7	2.3	-1.0	1.5
Frequency of tenseness / restlessness in last 2 weeks	3.2	5.0	5.2	2.2	-2.3
Hearing difficulty/problems with background noise	0.8	1.3	1.4	1.2	-1.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.2	-0.1
Had menopause	0.0	0.0	0.0	0.1	0.2
Had other major operations	0.1	0.1	0.2	-0.5	0.3
Forced vital capacity (FVC)	2.2	8.6	9.1	2.9	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	-0.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	-0.2	0.1
Qualifications: None of the above	0.2	0.5	0.8	0.9	-0.5
Financial difficulties in last 2 years	0.1	0.1	0.1	0.3	-0.3
Mouth/teeth dental problems	0.2	0.4	0.5	-0.7	0.6
Heart attack	0.0	0.0	0.1	0.2	-0.2
Allergy	0.1	0.3	0.4	0.4	-0.6
Pain all over the body in last month	0.0	0.0	0.0	-0.2	0.2
Diabetes (self-reported)	0.1	0.1	0.2	0.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	-0.6	0.7
Medication: Ramipril	0.3	0.4	0.6	-0.5	0.8
Medication: Simvastatin	0.9	1.3	1.4	-1.1	1.2
Fluid intelligence score	0.3	0.6	0.7	-0.6	0.9
Illnesses of siblings	0.2	0.3	0.3	-0.5	0.5
Neuroticism score	0.0	0.1	0.1	0.4	-0.2
Weight	3.3	16.3	17.5	3.9	-4.2
Impedance of arm (right)	0.6	2.6	2.9	-1.6	1.7
Arm fat percentage (right)	0.7	2.7	3.3	1.5	-1.8
Trunk fat-free mass	3.2	18.5	19.6	4.2	-4.4
Hip circumference	2.2	9.5	9.7	3.1	-3.1
Time employed in main current job	0.0	0.0	0.1	0.2	-0.1
Alcohol intake versus 10 years previously	0.3	0.5	0.6	-0.8	0.6
Father’s age at death	0.1	0.1	0.1	-0.3	0.3
Worrier / anxious feelings	0.7	1.4	1.5	-1.1	1.2
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.5	3.6	1.8	-1.9
Falls in the last year	0.4	0.6	0.7	0.7	-0.8
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	0.4	-0.1
Number of live births	0.4	0.5	0.7	-0.6	0.8
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	4.7	1.9	-2.2
Pulse rate	0.0	0.1	0.1	0.2	0.3
Happiness	0.2	0.2	0.3	0.6	-0.3
Noisy workplace	0.2	0.2	0.3	0.4	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	0.7	-0.8	0.7
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	2.4	1.5	-1.6
Mouth/teeth dental problems: Dentures	0.3	0.5	0.6	-0.6	0.8
Asthma	0.1	0.1	0.2	-0.3	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.1	1.0	-1.1
Medication: Cholesterol lowering	0.3	0.4	0.5	-0.6	0.7
Depression (self-reported)	1.6	1.9	2.2	1.2	-1.5
Medication: Lansoprazole	0.1	0.1	0.1	-0.4	0.2
Prospective memory result	1.0	1.2	1.4	1.0	-1.2
Lung cancer (father)	1.2	1.4	1.7	-1.1	1.3
Illnesses of mother	0.5	0.6	0.7	0.7	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	2.9	1.4	-1.7
Pulse wave Arterial Stiffness index	2.1	2.4	2.5	1.6	-1.6
Impedance of arm (left)	0.5	2.4	2.6	-1.5	1.6
Arm fat mass (right)	1.9	7.8	8.6	2.6	-2.9
Trunk predicted mass	3.4	19.5	20.5	4.3	-4.5
Standing height	2.3	22.3	22.9	4.7	-4.8
Length of working week for main job	9.4	10.4	11.2	3.1	-3.3
Exposure to tobacco smoke at home	0.5	0.6	0.7	0.7	-0.9
Breastfed as a baby	1.2	1.4	1.6	1.1	-1.2
Tense / ‘highly strung’	0.0	0.0	0.1	-0.1	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	2.3	-1.5	1.4
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.1	-0.3
Birth weight of first child	0.2	0.3	0.4	-0.6	0.5
Peak expiratory flow (PEF)	1.7	3.9	4.6	1.8	-2.1
Pulse wave reflection index	1.6	2.0	2.2	1.3	-1.5
Ever highly irritable/argumentative for 2 days	0.5	0.7	0.7	0.8	-0.8
Loud music exposure frequency	0.2	0.2	0.2	0.4	-0.4
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	3.6	-1.9	1.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.0	1.0	-0.8
Blood clot in the leg (DVT)	0.5	0.7	0.8	0.9	-0.8
Medication: Paracetamol	0.3	0.4	0.5	-0.6	0.7
Headache pain in last month	0.5	0.9	1.0	-0.9	1.0
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	-0.2	-0.0
Glaucoma (self-reported)	0.3	0.4	0.4	-0.7	0.5
Gout (self-reported)	0.7	0.9	1.2	1.1	-0.8
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	-0.0	0.2
Medication: Amlodipine	0.1	0.2	0.2	0.5	-0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	-0.2	0.4
Birth weight	1.3	2.9	3.1	1.6	-1.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	-0.6	0.4
High blood pressure (siblings)	0.0	0.0	0.0	0.1	0.1
Forced vital capacity (FVC), Best measure	1.8	6.7	7.0	2.5	-2.6
Body fat percentage	1.3	5.0	5.4	2.2	-2.3
Leg fat percentage (right)	1.2	4.2	4.7	1.9	-2.2
Arm fat-free mass (right)	4.3	21.8	23.0	4.5	-4.8
Exposure to tobacco smoke outside home	0.9	1.2	1.3	1.0	-1.1
Comparative body size at age 10	0.2	0.4	0.7	-0.8	0.4
Number of full brothers	6.7	8.4	8.5	2.9	-2.9
Worry too long after embarrassment	1.2	2.0	2.2	1.4	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	0.3
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	-0.1	0.0
Number of children fathered	5.2	5.9	6.2	2.3	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.1	-1.1	0.9
Age at first live birth	0.0	0.0	0.0	0.2	-0.2
Pulse wave peak to peak time	1.5	1.7	1.8	-1.3	1.3
Health satisfaction	2.8	3.7	3.7	1.9	-1.9
Shortness of breath walking on level ground	0.2	0.2	0.3	0.6	-0.4
Qualifications: College or University degree	0.2	0.6	0.8	-0.7	0.9
Eye problems/disorders: None of the above	0.0	0.0	0.0	0.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.0	0.0
Emphysema/chronic bronchitis	2.9	3.3	3.4	-1.8	1.8
Medication for pain relief, constipation, heartburn	1.1	1.8	1.9	-1.4	1.3
Neck or shoulder pain in last month	0.8	1.1	1.1	1.0	-1.1
Medication: Blood pressure	0.1	0.1	0.2	0.4	-0.1
Angina (self-reported)	0.6	0.8	0.8	-0.9	0.9
Migraine (self-reported)	0.0	0.0	0.0	-0.1	-0.0
Medication: Ibuprofen	0.1	0.1	0.1	0.2	-0.3
Medication: Allopurinol	0.0	0.1	0.1	0.3	-0.1
Medication: Omeprazole	0.7	0.9	1.1	1.0	-0.8
Medication: Seretide 50 evohaler	0.3	0.3	0.4	-0.6	0.5
Mean time to correctly identify matches	1.6	3.1	3.4	-1.7	1.9
Heart disease (mother)	0.8	0.9	1.4	-0.7	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.5	0.5
Whole body fat mass	2.5	10.6	11.5	3.1	-3.4
Leg fat mass (right)	2.0	7.8	8.6	2.6	-2.9
Arm predicted mass (right)	4.0	20.6	21.6	4.4	-4.7
Pulse rate, automated reading	0.1	0.4	0.7	0.8	-0.4
Alcohol intake frequency.	2.8	6.5	7.4	-2.4	2.7
Comparative height size at age 10	1.0	5.6	5.9	2.4	-2.3
Number of full sisters	0.8	1.0	1.2	0.8	-1.1
Suffer from ‘nerves’	0.0	0.0	0.1	0.3	-0.1
Overall health rating	1.2	2.6	2.6	1.6	-1.6
Chest pain or discomfort	0.6	0.8	0.9	-0.9	0.9
Had major operations	2.8	3.3	3.4	-1.8	1.9
Age at last live birth	0.5	0.7	0.8	-0.7	0.9
Family relationship satisfaction	1.2	1.5	1.8	-1.1	1.4
Leg pain on walking	2.0	2.6	2.7	1.6	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	-0.6	-0.1
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.1	1.1	-1.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	-0.4	0.7
Medication: Aspirin	0.6	0.7	0.9	1.0	-0.7
Supplements: Vitamin C	0.0	0.0	0.0	0.0	0.1
Knee pain experienced in last month	0.4	0.6	0.8	0.6	-0.9
Hypertension (Self-reported)	0.0	0.0	0.0	0.1	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	0.9	0.8	-0.9
Illnesses of father: Heart disease	0.1	0.1	0.1	-0.3	0.3
Illnesses of siblings: Diabetes	0.0	0.1	0.1	0.1	-0.3
Smoking status: Previous	1.5	2.2	2.7	1.3	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	5.7	11.9	13.7	3.2	-3.7
Whole body fat-free mass	3.6	20.8	22.0	4.4	-4.7
Leg fat-free mass (right)	3.2	17.3	18.4	4.0	-4.3
Arm fat percentage (left)	0.9	3.8	4.4	1.8	-2.1
Average weekly red wine intake	0.3	0.5	0.7	0.8	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.3	-0.6	0.5
Mood swings	1.4	2.5	2.6	-1.6	1.5
Loneliness, isolation	0.1	0.1	0.1	0.3	-0.3
Long-standing illness, disability or infirmity	0.2	0.2	0.3	-0.4	0.6
Ever had bowel cancer screening	1.5	1.7	2.1	-1.2	1.4
Diabetes diagnosed by doctor	0.0	0.1	0.2	-0.1	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	1.4	-1.2	1.1
Friendships satisfaction	0.2	0.2	0.3	0.6	-0.3
Qualifications: nursing, teaching	1.3	2.1	2.1	-1.4	1.4
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.4	0.3
Eye problems/disorders: Cataract	0.1	0.2	0.2	0.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	1.4	1.2	-1.2
Medication for cholesterol	0.0	0.0	0.0	0.0	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.2	0.4	-0.4
Back pain experienced in last month	2.7	3.9	4.2	2.0	-1.9
Mineral and other dietary supplements	1.8	2.5	2.5	1.6	-1.6
Breast cancer (self-reported)	0.4	0.5	0.6	0.8	-0.6
Asthma (self-reported)	0.3	0.7	0.7	-0.8	0.9
Osteoporosis (self-reported)	1.2	1.4	1.5	-1.2	1.2
Osteoarthritis (self-reported)	0.0	0.1	0.1	-0.3	0.1
Medication: Aspirin	0.1	0.1	0.2	0.4	-0.2
Medication: Gliclazide	4.5	5.0	5.6	-2.1	2.4
Illnesses of father: None of the above (group 1)	0.0	0.1	0.1	-0.3	0.2
Smoking status: Current	1.3	2.1	2.1	-1.5	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	0.1	-0.3
Whole body water mass	3.6	20.5	21.7	4.4	-4.7
Leg predicted mass (right)	3.2	17.2	18.3	4.0	-4.3
Arm fat mass (left)	2.2	8.9	9.9	2.8	-3.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.2	0.4
Average weekly champagne plus white wine intake	1.4	2.0	2.1	-1.4	1.4
Miserableness	0.4	0.8	0.8	-0.9	0.9
Guilty feelings	1.5	2.3	2.7	1.6	-1.4
Wears glasses or contact lenses	0.1	0.1	0.2	-0.3	0.4
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.0	0.3
Hearing aid user	5.3	6.0	6.4	2.5	-2.4
Mother’s age at death	3.8	4.8	4.9	-2.2	2.2
Financial situation satisfaction	2.3	2.9	3.0	1.7	-1.7
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.4	-0.1
Commuting to job workplace: Public transport	0.3	0.3	0.5	-0.4	0.7
Eye problems/disorders: Glaucoma	0.7	0.9	0.9	-1.0	0.9
Medication: Blood pressure	0.1	0.2	0.3	0.6	-0.4
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.0	0.1
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.2	-1.1	1.0
High cholesterol (Self-reported)	2.6	4.6	5.2	-2.0	2.3
Medication: Bendroflumethiazide	1.5	2.2	2.8	-1.3	1.7
Medication: Paracetamol	0.0	0.1	0.1	-0.0	0.3
Medication: Lisinopril	0.2	0.2	0.3	-0.5	0.5
Medication: Atorvastatin	0.2	0.2	0.4	-0.2	0.6
Illnesses of father: High blood pressure	0.5	0.6	0.6	0.8	-0.7
Alcohol drinker status: Never	0.1	0.1	0.1	-0.3	0.4
Ever smoked	2.1	3.8	4.1	1.8	-2.0
Basal metabolic rate	3.8	20.9	22.2	4.4	-4.7
Leg fat percentage (left)	1.3	4.9	5.3	2.1	-2.3
Arm fat-free mass (left)	3.8	19.5	20.5	4.3	-4.5
Number of operations (self-reported)	0.3	0.5	0.7	-0.8	0.6
Average weekly beer plus cider intake	0.2	0.3	0.5	0.4	-0.7
Irritability	1.2	2.0	2.3	1.5	-1.3
Risk taking	3.2	4.7	5.6	2.0	-2.4
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	-0.1	0.2
Fractured/broken bones in last 5 years	0.8	1.1	1.3	0.9	-1.2
Age started oral contraceptive pill	0.7	0.9	1.2	1.1	-0.7
Diastolic blood pressure, automated reading	1.4	4.5	4.5	-2.1	2.1
Ever depressed for a whole week	0.4	0.5	0.6	0.7	-0.7
Unable to work because of sickness or disability	0.5	0.7	0.7	0.9	-0.8
Commuting to job workplace: Cycle	1.6	1.9	2.1	-1.4	1.3
Myopia	2.2	3.2	3.9	-1.6	2.0
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.5	0.7	-0.7
Cholesterol lowering medication	1.1	1.6	1.8	-1.2	1.4
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	3.2	1.8	-1.5
Pain experienced in last month	0.3	0.5	0.6	-0.7	0.8
Supplements: Calcium	1.0	1.1	1.4	-0.9	1.2
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	-0.0	0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.5	0.7	-0.6
Heart disease (siblings)	0.5	0.6	0.8	-0.7	0.9
Alcohol drinker status: Previous	1.1	1.2	1.3	-1.1	1.1
Pack years of smoking	0.2	0.3	0.3	0.6	-0.5
Impedance of whole body	0.3	1.3	1.5	-1.1	1.2
Leg fat mass (left)	2.2	8.6	9.4	2.8	-3.1
Arm predicted mass (left)	3.6	18.1	19.1	4.1	-4.4