TWAS hub - PAFAH2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1370	0.0380	2.3e-07	0.066	0.056	0.063	0.060	0.065	2.0e-08	2.2e-07	3.9e-08	7.6e-08	2.5e-08
2	GTEx	Brain Cerebellar Hemisphere	0.3220	0.0920	1.7e-04	0.168	NA	0.275	NA	0.275	4.3e-05	NA	9.4e-08	NA	9.7e-08
3	GTEx	Muscle Skeletal	0.0793	0.0303	2.3e-04	0.045	NA	0.041	NA	0.043	3.1e-05	NA	6.1e-05	NA	4.1e-05
4	NTR	Blood	0.0406	0.0149	4.3e-05	0.022	0.013	0.022	0.019	0.029	9.0e-08	2.9e-05	1.2e-07	6.5e-07	8.2e-10
5	ROSMAP	Brain Pre-frontal Cortex	0.0675	0.0233	9.9e-06	0.054	0.050	0.066	0.059	0.061	1.8e-07	4.9e-07	6.9e-09	4.7e-08	2.6e-08
6	YFS	Blood	0.0599	0.0189	4.1e-08	0.040	0.025	0.045	0.044	0.044	3.4e-13	7.7e-09	1.7e-14	2.4e-14	3.7e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Chronic bronchitis/emphysema (mother)	6.8	8.0	15.8	0.8	-3.2	-4.0	2.6	-1.2	3.6
Ever depressed for a whole week	4.5	5.5	12.2	-2.9	-2.3	-1.6	-2.1	-3.5	-0.6
Maternal smoking around birth	4.3	6.2	12.4	1.2	-2.8	-3.5	2.1	-0.2	3.3
Pulse rate, automated reading	4.2	13.5	26.3	1.4	-3.7	-4.6	4.0	-1.4	5.1
Eye problems/disorders: Diabetes related eye disease	3.9	4.3	7.8	0.7	-2.5	-2.5	1.9	-1.0	2.8
Diabetes (mother)	3.6	4.6	9.6	-1.4	-2.8	-3.1	0.4	-2.5	1.3
Type 2 Diabetes (T2D) (2012)	3.5	4.0	7.6	-2.3	-2.8	-1.6	-0.9	-2.7	0.1
Supplements: Fish oil (including cod liver oil)	3.5	4.6	9.2	-0.1	2.7	3.0	-1.9	0.7	-2.6
Forced expiratory volume in 1-second (FEV1)	3.4	11.3	17.3	-3.2	3.4	3.6	-4.2	-1.0	-3.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.2	3.8	8.7	-1.2	-2.4	-2.9	0.4	-2.1	1.6
Mineral and other dietary supplements	3.1	4.2	9.6	-0.6	-2.6	-3.1	1.2	-1.4	2.3
Vitamin and mineral supplements	3.0	4.0	11.4	-0.7	-2.3	-3.4	1.3	-1.2	2.0
Ever taken oral contraceptive pill	3.0	3.4	8.1	-1.1	-2.9	-2.1	-0.0	-2.2	1.2
Supplements: Vitamin C	2.9	3.5	9.9	0.4	2.1	3.1	-1.2	1.3	-1.8
Ever unenthusiastic/disinterested for a whole week	2.8	3.4	8.0	-2.1	-1.2	-0.2	-2.1	-2.8	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	8.9	13.0	-2.3	3.4	3.6	-3.5	0.1	-3.4
Coronary Artery Disease (CAD)	2.7	3.2	6.2	1.9	-1.5	-1.4	2.2	0.6	2.5
Supplements: Glucosamine	2.7	3.6	8.7	0.6	3.0	2.8	-0.9	1.2	-1.5
Osteoporosis (self-reported)	2.7	3.3	7.9	2.8	-0.6	-0.2	2.0	2.1	1.7
Bipolar Disorder (2018)	2.6	4.1	7.4	0.8	-2.2	-2.6	2.1	0.1	2.7
Peak expiratory flow (PEF)	2.6	6.1	10.2	-2.3	2.3	2.5	-3.2	-1.0	-2.9
High blood pressure (siblings)	2.6	3.8	6.5	-0.8	2.4	2.2	-2.2	-0.3	-2.5
Arm predicted mass (right)	2.6	13.1	21.3	-4.2	2.9	3.6	-4.6	-0.7	-4.2
Qualifications: nursing, teaching	2.6	4.0	7.7	-1.7	1.6	1.8	-2.8	-0.5	-2.8
Arm fat-free mass (right)	2.4	12.5	19.9	-3.8	3.0	3.7	-4.5	-0.5	-4.2
Alcohol intake frequency.	2.4	5.5	8.6	-2.9	1.2	1.0	-2.9	-2.4	-2.8
LDL Cholesterol	2.3	3.7	6.8	1.0	-2.6	-2.1	1.9	-0.1	2.5
Severe depression (siblings)	2.3	2.6	6.3	-2.0	-1.2	-0.6	-1.7	-2.5	-0.7
Multivitamins +/- minerals	2.3	2.9	7.2	0.8	2.1	2.7	-1.1	1.0	-1.7
Forced vital capacity (FVC)	2.3	8.8	13.0	-3.1	3.2	2.9	-3.6	-0.7	-3.2
Pulse rate	2.3	3.9	8.7	0.9	-1.3	-2.3	2.6	-0.3	2.9
Illnesses of mother	2.3	2.9	5.7	-0.4	2.0	2.4	-1.8	0.4	-2.0
Forced vital capacity (FVC), Best measure	2.3	8.5	12.3	-2.3	3.4	3.5	-3.4	0.4	-3.3
Medication: Seretide 50 evohaler	2.3	2.7	5.3	0.5	2.3	2.1	-0.7	1.6	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.9	7.9	-1.1	2.8	2.6	-2.5	0.7	-2.6
Type 2 Diabetes (T2D) (2018)	2.2	4.0	10.6	-0.7	-2.0	-3.3	0.5	-2.4	1.8
Trunk fat-free mass	2.1	12.1	17.8	-3.1	3.6	4.2	-3.9	0.4	-4.0
Trunk predicted mass	2.1	11.9	17.5	-3.1	3.6	4.2	-3.9	0.5	-4.0
Ever highly irritable/argumentative for 2 days	2.1	2.5	5.9	-0.6	-2.4	-1.9	0.9	-1.2	1.6
Comparative height size at age 10	2.1	11.5	20.6	-1.9	3.6	4.5	-3.7	0.4	-4.3
Whole body fat-free mass	2.1	12.0	16.8	-3.3	3.5	4.0	-4.1	-0.0	-4.0
Leg fat-free mass (right)	2.1	11.1	16.9	-3.3	3.1	3.6	-4.1	-0.5	-4.0
Whole body water mass	2.1	12.0	17.1	-3.4	3.4	3.9	-4.1	-0.1	-4.0
Leg predicted mass (right)	2.1	11.1	17.0	-3.3	3.1	3.5	-4.1	-0.5	-4.0
Arm fat-free mass (left)	2.1	10.5	15.9	-3.5	3.0	3.4	-4.0	-0.3	-3.8
Triglycerides	2.0	3.3	6.7	-1.4	-2.6	-2.2	-0.2	-2.1	1.5
Leg fat-free mass (left)	2.0	10.7	16.0	-3.2	3.1	3.6	-4.0	-0.5	-3.9
Hand grip strength (right)	2.0	5.3	11.3	-0.8	3.1	3.4	-2.2	0.1	-2.3
Leg predicted mass (left)	2.0	10.5	15.8	-3.1	3.1	3.6	-4.0	-0.5	-3.9
Alcohol intake versus 10 years previously	2.0	2.9	6.3	-2.5	-0.3	-0.6	-1.8	-2.5	-1.1
Medication: Omeprazole	2.0	2.4	4.3	0.3	-1.6	-1.9	1.2	-1.6	2.1
Body Mass Index (BMI) (2010)	1.9	2.6	4.6	-0.4	2.0	2.1	-1.6	0.0	-2.1
Lung FVC	1.9	9.6	14.2	-1.9	3.7	3.6	-3.6	0.3	-3.8
Medication: Metformin	1.9	2.6	6.0	-0.0	-1.9	-2.4	1.0	-1.5	1.7
Alcohol usually taken with meals	1.9	3.1	9.1	0.6	2.1	3.0	-0.7	1.7	-1.2
Number of full brothers	1.9	2.3	4.7	0.2	-1.8	-2.2	1.4	-0.5	1.9
Medication: Gliclazide	1.9	2.1	4.8	0.3	-1.4	-2.2	0.9	-0.9	1.9
Basal metabolic rate	1.9	10.6	15.8	-3.3	3.0	3.6	-4.0	-0.4	-3.8
Ever had prostate specific antigen (PSA) test	1.9	2.2	4.6	-0.7	1.8	2.1	-1.2	-0.0	-1.9
Bipolar Disorder (2011)	1.8	1.7	2.9	0.9	-1.3	-1.7	1.7	0.5	1.5
Townsend deprivation index at recruitment	1.8	2.5	4.9	-1.4	-2.2	-2.1	-0.2	-1.9	0.3
Fed-up feelings	1.8	3.3	6.6	-0.8	-2.1	-2.6	0.8	-2.1	1.9
Heart attack	1.8	2.3	4.7	0.0	-2.0	-2.2	1.3	-0.1	1.8
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	4.7	-0.2	-2.0	-2.2	1.0	-0.9	1.6
Heart attack/myocardial infarction (self-reported)	1.8	2.3	4.4	0.3	-1.9	-2.1	1.4	0.2	1.8
Illnesses of siblings	1.7	2.3	3.8	1.4	-1.4	-1.2	2.0	0.9	1.9
Prospective memory result	1.7	2.1	4.5	2.1	0.9	1.0	1.3	2.1	0.6
Medication: Allopurinol	1.7	2.3	6.0	-1.7	-0.9	-1.2	-1.5	-2.4	-0.8
Handedness (chirality/laterality): Left-handed	1.7	2.1	3.9	2.0	-0.2	0.8	1.7	1.9	1.2
Pain type(s) experienced in last month: Hip pain	1.7	2.1	4.5	-1.9	-0.6	-0.1	-1.7	-2.1	-1.1
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.5	-1.9	-0.2	-0.2	-1.7	-1.7	-1.4
Past tobacco smoking	1.6	3.0	6.2	-1.1	1.2	2.0	-2.2	-0.1	-2.5
Had other major operations	1.6	2.0	4.0	0.4	-2.0	-1.5	1.4	-0.1	1.9
Birth weight of first child	1.6	3.0	5.5	-1.3	1.9	1.8	-1.9	0.0	-2.4
Worry too long after embarrassment	1.6	2.7	6.2	0.7	2.5	2.4	-0.6	1.2	-1.3
Medication: Ibuprofen	1.6	1.9	4.5	-2.1	-0.7	-0.5	-1.5	-2.0	-0.6
Arm predicted mass (left)	1.6	8.3	12.4	-3.3	2.7	2.9	-3.5	-0.3	-3.3
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	4.8	-0.6	1.1	1.8	-1.5	-0.2	-2.2
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	5.0	-1.7	-0.5	-0.3	-1.3	-2.2	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	6.7	-1.4	2.0	1.7	-2.0	-0.8	-2.6
Neck or shoulder pain in last month	1.5	2.1	7.3	-1.2	-1.5	-1.1	-0.5	-2.7	0.5
Basal cell carcinoma (self-reported)	1.5	1.8	2.7	1.5	-0.9	-1.2	1.4	1.2	1.6
Height	1.4	27.8	52.3	-3.7	5.7	7.2	-5.4	0.2	-6.2
Hand grip strength (left)	1.4	3.6	10.0	0.7	2.5	3.2	-0.8	1.3	-1.4
Sitting height	1.4	10.0	15.9	-3.0	2.6	3.8	-4.0	0.1	-3.8
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	4.3	-1.6	-1.8	-1.6	-0.7	-2.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	5.2	-0.9	-1.6	-2.3	0.9	-1.4	1.5
Noisy workplace	1.4	1.7	3.4	-1.6	-1.7	-0.9	-0.8	-1.8	-0.4
Medication: Lansoprazole	1.4	1.6	3.7	-0.9	0.4	0.6	-1.9	-1.2	-1.9
Glaucoma (self-reported)	1.4	1.7	3.4	1.8	-0.5	-0.2	1.8	1.0	1.5
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	5.4	-1.7	-2.3	-1.8	-0.6	-2.0	0.7
Diabetes diagnosed by doctor	1.4	2.3	6.1	-0.3	-1.8	-2.5	0.4	-1.7	1.2
Average weekly beer plus cider intake	1.4	2.1	6.2	-0.2	-1.6	-2.5	0.7	-0.9	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.4	-1.4	-1.9	-1.2	-0.6	-1.7	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.4	0.3	-1.8	-1.5	0.7	-0.4	1.3
High cholesterol (Self-reported)	1.3	2.2	4.6	-0.1	-2.1	-2.1	1.0	-1.1	1.4
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.7	-0.4	-1.6	-1.6	0.3	-1.9	1.1
Impedance of leg (right)	1.2	5.7	9.8	1.5	-3.1	-2.7	2.5	-0.8	2.9
Average weekly fortified wine intake	1.2	1.4	3.3	-1.0	0.8	1.3	-1.2	-0.0	-1.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.8	-0.8	-1.7	-0.9	-0.9	-1.6	-0.5
Impedance of leg (left)	1.2	5.6	10.6	1.4	-3.3	-2.8	2.3	-0.8	2.7
Number of live births	1.2	1.7	3.8	0.5	-0.5	-1.9	1.5	-0.5	1.9
Standing height	1.2	11.7	20.8	-2.7	3.5	4.6	-3.8	0.1	-4.0
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.7	0.5	-0.6	-1.3	1.7	0.6	1.9
Birth weight	1.2	2.6	6.2	-0.4	2.5	2.1	-1.0	1.1	-1.7
Qualifications: College or University degree	1.2	3.8	7.1	-1.6	0.8	2.5	-2.7	-0.4	-2.5
Emphysema/chronic bronchitis	1.2	1.3	2.0	1.4	-0.7	-1.0	1.4	1.1	1.2
Mother’s age at death	1.2	1.4	4.1	-0.2	1.6	2.0	-0.7	0.6	-1.1
Alcohol drinker status: Previous	1.2	1.4	4.2	-1.5	-0.7	-0.6	-0.9	-2.0	-0.4
Reaction Time	1.1	2.0	3.5	-0.8	1.7	1.4	-1.9	-0.2	-1.8
Waist Hip Ratio (WHR)	1.1	4.8	12.6	-1.3	-2.2	-2.8	0.5	-3.5	1.4
Hypothyroidism (self reported)	1.1	2.5	4.9	-1.7	-1.9	-1.6	-0.7	-2.2	0.6
Supplements: Zinc	1.1	1.1	3.2	1.8	0.0	0.4	1.2	1.2	0.8
Diabetes (father)	1.1	1.3	2.6	1.6	-1.2	-0.8	1.2	-0.1	1.3
Weight	1.1	5.3	8.5	-2.6	1.6	2.3	-2.9	-1.1	-2.7
Mean time to correctly identify matches	1.1	2.2	3.6	-0.4	1.9	1.8	-1.5	0.3	-1.9
Heart disease (mother)	1.1	1.3	3.0	-0.5	-1.3	-1.5	0.3	-1.7	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.0	2.0	0.5	1.3	0.6	1.1	0.0
Bipolar Disorder or Schizophrenia	1.0	2.5	4.8	1.1	-1.9	-2.2	1.6	0.3	1.8
Schizophrenia vs Biploar Disorder	1.0	1.3	3.4	-0.3	0.1	1.5	-1.3	0.6	-1.8
Primary Biliary Cirrhosis	1.0	1.4	2.6	0.9	-1.5	-1.0	1.6	0.9	1.1
Taking other prescription medications	1.0	1.6	4.0	-1.3	-1.5	-0.3	-1.2	-2.0	-0.5
Qualifications: CSEs or equivalent	1.0	1.4	2.8	1.0	-0.9	-1.5	1.1	0.1	1.7
Worrier / anxious feelings	1.0	2.0	3.8	1.5	1.3	1.8	0.4	1.9	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.0	-1.7	-0.7	0.2	-1.7	-0.9	-1.3
Mouth/teeth dental problems: Loose teeth	1.0	1.1	3.2	-1.2	-0.4	-1.4	-0.4	-1.8	0.1
Illnesses of siblings: Diabetes	1.0	1.2	3.3	-1.2	-0.4	-0.9	-0.9	-1.8	-0.7
Smoking status: Previous	1.0	1.5	3.8	0.9	-0.3	-1.4	1.6	0.2	1.9
Irritability	1.0	1.7	2.6	0.8	-1.3	-1.4	1.5	-1.0	1.6
Age started oral contraceptive pill	1.0	1.2	2.8	-0.4	1.0	1.5	-1.2	-0.0	-1.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	3.6	0.1	-1.4	-1.1	0.2	-1.9	0.9
Mean Putamen Volume	0.9	1.1	2.7	0.5	1.6	1.5	0.0	0.9	-0.5
Neuroticism (2016)	0.9	1.2	2.8	-1.7	0.4	0.2	-1.2	-1.3	-1.1
Respiratory disease	0.9	2.0	3.6	-0.8	1.9	1.3	-1.8	-0.1	-1.7
Number of treatments/medications taken	0.9	1.6	3.1	-1.1	0.6	1.1	-1.6	-0.9	-1.8
Ever had hysterectomy (womb removed)	0.9	1.0	2.8	-1.0	-0.7	-1.1	-0.6	-1.7	0.1
Systolic blood pressure, automated reading	0.9	2.7	5.2	0.2	2.3	2.2	-0.9	1.3	-1.9
Trunk fat mass	0.9	3.8	6.3	-2.3	0.3	1.3	-2.5	-2.1	-2.2
Diabetes (self-reported)	0.9	1.4	3.6	-0.1	-1.5	-1.9	0.5	-1.3	1.0
Falls in the last year	0.9	1.2	2.6	-1.3	0.6	0.7	-1.0	-1.6	-1.0
Hair/balding pattern: Pattern 3	0.9	1.3	3.1	1.4	1.1	0.8	1.0	1.8	0.4
Qualifications: A levels/AS levels or equivalent	0.9	2.0	3.9	-1.2	1.0	1.4	-1.9	0.1	-2.0
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.7	-1.6	0.7	0.7	-1.6	-0.4	-1.5
Exposure to tobacco smoke outside home	0.9	1.2	2.2	1.3	-0.5	-1.0	1.5	0.6	1.2
Suffer from ‘nerves’	0.9	1.5	3.2	0.8	-1.2	-1.1	1.8	0.1	1.6
Commuting to job workplace: Walk	0.9	1.0	1.8	-0.2	1.1	1.3	-1.1	-0.1	-1.3
Crohns Disease (2012)	0.8	1.3	2.2	1.5	1.3	1.2	0.3	1.4	-0.6
Ulcerative Colitis	0.8	1.2	2.9	-1.1	-1.1	-0.8	-1.1	-1.7	-0.6
Current tobacco smoking	0.8	1.3	3.0	0.2	-1.7	-1.2	1.3	-0.6	1.1
Time employed in main current job	0.8	1.0	1.9	0.7	-0.9	-0.4	1.4	1.1	1.1
Breastfed as a baby	0.8	1.0	1.8	0.9	1.1	1.4	-0.1	1.0	-1.0
Age at last live birth	0.8	1.2	2.3	1.1	0.0	-0.2	1.5	1.1	1.5
Leg pain on walking	0.8	1.0	2.0	0.9	-1.1	-0.8	1.1	0.0	1.4
Eye problems/disorders: Cataract	0.8	1.0	2.0	-0.9	-1.3	-1.4	-0.2	-1.1	0.4
Asthma (self-reported)	0.8	1.6	2.8	-0.5	1.6	1.1	-1.7	0.6	-1.7
Commuting to job workplace: Public transport	0.8	0.9	2.3	-0.6	-1.3	0.0	-1.0	-1.5	-0.6
Eye problems/disorders: Glaucoma	0.8	1.0	1.9	1.1	-0.6	-0.6	1.4	0.5	1.3
Medication: Paracetamol	0.8	1.3	2.4	-1.2	-1.4	-1.2	-0.7	-1.6	0.1
Cholesterol lowering medication	0.8	1.1	2.2	-0.4	-1.4	-1.5	0.5	-1.0	1.0
Alzheimer’s Disease (in father)	0.7	0.7	1.5	-1.0	0.6	0.3	-1.0	-0.5	-1.2
Lupus	0.7	1.1	2.8	1.1	-0.3	-0.4	1.7	1.0	1.0
Smoking Status	0.7	1.7	3.4	0.5	-1.2	-1.5	1.7	-0.0	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.8	-1.7	0.3	0.3	-1.5	-1.4	-1.4
Hearing difficulty/problems with background noise	0.7	1.2	2.0	0.8	-1.2	-1.4	1.4	0.2	1.0
Impedance of arm (right)	0.7	3.4	5.2	2.3	-1.6	-1.7	2.3	-0.2	2.2
Hip circumference	0.7	2.9	5.3	-2.0	0.8	1.6	-2.3	-0.9	-2.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.2	-1.5	-0.4	-0.4	-0.8	-1.5	0.0
Length of working week for main job	0.7	0.7	1.9	0.7	1.0	0.6	0.8	1.4	0.4
Gout (self-reported)	0.7	1.0	2.6	-0.6	-1.0	-1.3	-0.3	-1.6	-0.0
Comparative body size at age 10	0.7	1.9	3.6	1.6	1.9	1.3	0.8	1.7	-0.3
Angina (self-reported)	0.7	0.9	1.6	0.9	-0.5	-1.0	1.3	0.6	1.0
Migraine (self-reported)	0.7	0.8	1.7	-0.4	-1.3	-0.9	0.1	-1.2	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.7	-0.5	0.9	1.0	-1.1	0.3	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.4	-0.8	0.6	0.9	-1.0	-1.2	-0.7
Average weekly red wine intake	0.7	1.1	2.5	0.3	1.3	1.6	-0.4	1.0	-0.9
Medication for cholesterol	0.7	1.1	2.9	-0.2	-1.5	-1.7	0.5	-0.3	0.9
Smoking status: Current	0.7	1.2	2.7	0.4	-1.6	-1.1	1.3	-0.3	1.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.6	0.3	1.2	1.3	-0.6	0.7	-1.0
Medication: Blood pressure	0.7	1.2	3.8	0.2	1.9	1.4	-0.4	0.6	-1.1
Pack years of smoking	0.7	1.0	2.1	1.2	-0.7	-0.6	1.4	0.9	1.0
Impedance of whole body	0.7	3.7	5.6	1.5	-2.4	-2.2	1.9	-0.8	2.2
Depressed Affect (Nagel 2018)	0.6	1.2	3.2	-0.4	-0.9	-1.8	0.6	-1.2	1.1
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.4	-0.7	-2.0	-2.1	0.1	-0.9	1.1
Ulcerative Colitis (UC)	0.6	1.2	2.4	-1.4	-0.5	-0.4	-1.3	-1.6	-0.9
HbA1C	0.6	0.7	1.4	-0.6	-0.5	-1.2	0.3	-1.0	1.1
HDL Cholesterol	0.6	1.0	1.9	0.8	1.0	1.3	0.2	1.4	-0.7
Blood Eosinophil Count	0.6	4.7	11.7	0.0	-2.5	-3.4	2.0	-1.2	2.2
Blood Red Count	0.6	5.4	19.4	-3.0	-1.4	-1.0	-1.1	-4.4	-0.2
BMI	0.6	3.3	5.2	-2.1	1.3	1.3	-2.3	-1.6	-2.0
Trunk fat percentage	0.6	2.4	6.2	-1.7	-0.7	0.3	-1.7	-2.5	-1.4
Stomach or abdominal pain in last month	0.6	0.8	1.5	-0.8	0.9	0.4	-1.1	-0.6	-1.2
Medication: Ramipril	0.6	0.7	1.4	-0.8	-1.1	-1.0	-0.4	-1.2	0.2
Fluid intelligence score	0.6	1.3	2.3	-1.2	-1.3	-1.5	-0.3	-1.2	0.8
Exposure to tobacco smoke at home	0.6	0.7	1.3	0.3	-1.1	-0.9	1.1	-0.3	0.9
Eye problems/disorders: None of the above	0.6	0.7	1.4	0.3	1.2	1.1	-0.4	0.6	-0.9
Whole body fat mass	0.6	2.7	4.4	-2.1	0.1	0.9	-2.1	-1.9	-1.7
Number of full sisters	0.6	0.7	1.6	-0.9	-0.8	-0.9	-0.4	-1.3	-0.1
Family relationship satisfaction	0.6	0.7	1.7	0.5	-1.0	-1.3	0.8	-0.3	0.8
Illnesses of father: Heart disease	0.6	0.8	2.6	0.9	-1.6	-0.5	0.5	-0.3	0.8
Friendships satisfaction	0.6	0.7	1.6	-1.3	0.8	-0.2	-1.0	-0.7	-0.9
Arm fat mass (left)	0.6	2.4	3.9	-1.8	0.6	1.1	-2.0	-1.5	-1.8
Average weekly champagne plus white wine intake	0.6	0.8	2.6	0.2	-0.4	-0.9	1.1	-0.0	1.6
Miserableness	0.6	1.1	2.9	-0.8	-0.2	-1.7	-0.2	-1.5	0.9
Financial situation satisfaction	0.6	0.8	1.8	-0.8	-1.3	-0.7	-0.2	-1.3	0.1
Medication: Lisinopril	0.6	0.8	1.3	1.0	1.1	0.5	0.9	1.0	0.7
Pain experienced in last month	0.6	1.1	3.0	0.8	1.3	0.9	0.2	1.7	-0.5
Worry (Nagel 2018)	0.5	1.0	2.3	1.5	-0.1	1.0	1.2	1.1	0.1
Age at First Birth	0.5	0.8	1.5	1.0	1.2	0.8	0.3	1.2	0.1
Blood Platelet Count	0.5	5.3	18.1	-2.9	-0.6	-0.9	-2.0	-4.2	-0.7
Heel T-Score	0.5	4.0	7.9	-0.3	2.4	2.8	-1.5	-0.2	-2.8
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.9	-1.3	-0.1	0.0	-0.6	-1.4	-0.4
Angina	0.5	0.6	1.2	0.7	-0.5	-0.9	1.1	0.5	0.9
Medication for hormone replacement therapy	0.5	0.6	1.6	1.2	-0.0	1.0	0.6	0.7	0.2
Relative age voice broke	0.5	0.7	1.6	-1.0	-1.1	-0.7	-0.4	-1.2	-0.2
Waist circumference	0.5	1.9	4.8	-1.9	-0.1	0.1	-1.4	-2.2	-1.0
Nervous feelings	0.5	1.0	1.9	1.3	0.3	0.9	1.1	1.4	0.1
Asthma	0.5	1.0	1.8	-0.4	1.2	0.7	-1.3	0.4	-1.3
Arm fat mass (right)	0.5	2.0	3.2	-1.5	0.8	1.3	-1.8	-1.2	-1.7
Tense / ‘highly strung’	0.5	0.8	2.8	0.2	-1.7	-1.0	0.8	-0.3	0.7
Loud music exposure frequency	0.5	0.6	1.2	-0.7	-0.7	-1.0	-0.1	-1.1	0.6
Medication: Amlodipine	0.5	0.8	1.2	-1.1	0.4	0.6	-1.0	-0.8	-1.0
Number of children fathered	0.5	0.6	1.7	0.2	1.1	1.3	-0.5	0.1	-0.6
Age at first live birth	0.5	0.9	2.5	1.0	0.5	0.3	0.8	1.6	0.9
Medication for pain relief, constipation, heartburn	0.5	0.8	2.1	0.4	0.9	1.0	-0.0	1.4	-0.9
Long-standing illness, disability or infirmity	0.5	0.7	2.1	0.1	-1.5	-1.0	0.8	-0.6	0.5
Wears glasses or contact lenses	0.5	0.6	1.0	-0.8	-0.7	-0.0	-0.9	-1.0	-0.7
Irritable Bowel Disease (IBD)	0.4	0.9	1.9	-1.1	0.1	0.4	-1.4	-0.9	-1.3
Breast Cancer	0.4	0.9	2.5	-1.6	-0.5	-0.6	-1.1	-1.1	-0.2
Cardiovascular Disease	0.4	1.3	2.9	-1.3	0.4	0.4	-1.7	-0.8	-1.5
Lung FEV1/FVC ratio	0.4	1.8	4.7	0.1	1.7	2.2	-1.0	0.5	-1.5
Medication: Co-codamol	0.4	0.5	1.6	-0.5	1.3	0.7	-0.5	0.3	-0.6
Pack years adult smoking proportion	0.4	0.6	0.9	0.6	-0.9	-0.9	1.0	0.2	0.9
High blood pressure	0.4	1.1	1.9	-1.0	1.1	0.7	-1.1	-0.6	-1.4
Number of incorrect matches in round	0.4	0.6	1.4	-0.2	0.4	1.2	-0.7	0.8	-1.1
Hair/balding pattern: Pattern 2	0.4	0.6	1.8	0.2	-1.3	-1.1	-0.1	-0.4	0.5
Qualifications: None of the above	0.4	0.8	1.8	1.2	0.2	-0.5	1.3	0.5	1.0
Father’s age at death	0.4	0.6	1.2	-1.1	0.5	0.6	-1.0	-0.5	-0.4
Impedance of arm (left)	0.4	1.7	2.6	1.6	-1.3	-1.1	1.5	-0.5	1.4
Medication: Paracetamol	0.4	0.7	1.4	-0.5	-1.1	-1.2	-0.1	-1.1	0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.2	-1.1	0.0	-0.4	-1.0	-0.2	-1.0
Body fat percentage	0.4	1.7	5.2	-1.4	-0.9	-0.1	-1.2	-2.3	-0.8
Leg fat mass (right)	0.4	1.4	2.7	-1.6	-0.5	0.2	-1.4	-1.6	-0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.4	0.4	1.1	0.2	0.6	1.2	0.0
Knee pain experienced in last month	0.4	0.6	1.8	-0.9	-0.6	-0.5	-0.5	-1.3	-0.2
Hypertension (Self-reported)	0.4	1.2	2.2	-0.9	1.4	1.0	-1.2	-0.3	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.2	0.8	0.8	1.3	0.2	1.5	0.2
Loneliness, isolation	0.4	0.5	0.9	-0.8	-0.9	-0.8	-0.4	-1.0	0.0
Ever had bowel cancer screening	0.4	0.4	1.7	-0.4	1.3	0.8	-0.2	0.1	-0.3
Medication: Aspirin	0.4	0.5	1.0	0.7	-0.0	-0.6	1.0	0.4	0.9
Medication: Atorvastatin	0.4	0.5	1.2	0.0	-0.9	-1.1	0.3	-0.6	0.7
Illnesses of father: High blood pressure	0.4	0.5	1.5	-0.2	-1.2	-0.7	0.2	-0.3	0.7
Alcohol drinker status: Never	0.4	0.5	0.9	-0.8	0.5	0.3	-0.9	-0.4	-0.9
Ever smoked	0.4	0.7	1.1	-0.2	-0.9	-1.1	0.7	-0.8	1.0
Fractured/broken bones in last 5 years	0.4	0.5	1.3	0.4	-0.4	-0.9	0.8	-0.1	1.1
Myopia	0.4	0.5	1.6	0.5	0.5	1.2	-0.2	0.7	-0.7
Supplements: Calcium	0.4	0.5	2.0	1.4	0.1	0.6	0.4	0.6	0.0
Leg fat mass (left)	0.4	1.4	2.8	-1.7	-0.5	0.2	-1.4	-1.6	-0.9
Depression (Nagel 2018)	0.3	0.4	1.0	-0.1	-0.8	-0.6	0.1	-1.0	0.6
Crohns Disease (2017)	0.3	0.6	1.2	0.5	0.9	1.1	-0.2	0.8	-0.8
Major Depression (MDD)	0.3	0.4	0.8	-0.9	0.6	-0.2	-0.9	-0.3	-0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.7	-0.7	-1.2	-1.3	0.1	-0.1	0.5
Prostate Cancer	0.3	0.4	0.9	0.1	-1.0	-0.7	0.7	0.3	0.5
Rheumatoid Arthritis	0.3	0.4	1.1	1.0	0.3	0.4	0.4	0.8	0.4
Schizophrenia (2014)	0.3	0.6	1.9	1.4	-0.8	0.1	0.7	1.0	0.1
Blood White Count	0.3	2.0	4.3	-1.4	-0.4	1.2	-1.2	-2.1	-1.6
Chronotype (morning person)	0.3	0.7	1.5	1.2	0.9	0.6	0.7	1.0	0.3
Serious illness, injury or assault to yourself	0.3	0.4	1.1	0.7	0.5	0.5	0.1	1.1	-0.2
Medication: Levothyroxine sodium	0.3	0.6	1.1	-0.9	-0.8	-0.9	-0.2	-1.1	0.4
High blood pressure (mother)	0.3	0.4	1.0	-1.0	-0.8	-0.3	-0.4	-0.6	-0.2
Hair/balding pattern: Pattern 4	0.3	0.7	1.7	-0.3	-0.2	-1.3	1.0	-0.8	1.0
Headache pain in last month	0.3	0.5	2.0	-0.6	-0.2	-0.2	-0.7	-1.4	0.0
Wheeze or whistling in the chest in last year	0.3	0.5	1.1	-0.7	0.2	-0.2	-0.8	-1.1	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.5	0.7	0.4	0.7	0.8	0.1
Health satisfaction	0.3	0.4	1.3	-0.6	-0.6	-0.7	-0.3	-1.1	0.3
Shortness of breath walking on level ground	0.3	0.3	0.6	-0.5	-0.8	-0.8	0.1	-0.3	0.5
Overall health rating	0.3	0.6	1.7	-0.8	-0.5	-0.6	-0.5	-1.3	-0.5
Chest pain or discomfort	0.3	0.4	0.8	0.7	0.0	-0.5	0.9	0.0	0.9
Medication: Aspirin	0.3	0.4	0.8	0.9	-0.2	-0.4	0.9	0.4	0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.7	0.7	0.8	0.8	-0.1	0.7	-0.6
Back pain experienced in last month	0.3	0.4	1.0	-0.1	-0.0	-0.9	0.6	-0.5	1.0
Illnesses of father: None of the above (group 1)	0.3	0.4	1.5	-0.6	1.2	0.2	-0.5	0.3	-0.6
Guilty feelings	0.3	0.4	1.0	0.5	1.0	0.9	0.5	0.5	-0.2
Hearing aid user	0.3	0.3	0.7	0.4	-0.4	-0.5	0.8	0.6	0.6
Leg fat percentage (left)	0.3	0.9	2.4	-0.6	-1.4	-0.9	-0.1	-1.5	0.3
Risk taking	0.3	0.4	1.5	-0.1	0.9	1.2	-0.4	0.1	-0.5
Diastolic blood pressure, automated reading	0.3	0.8	1.9	0.5	-0.1	-0.9	1.2	0.7	1.4
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.3	1.1	-0.8	-0.4	1.0	0.7	1.1
Ovarian Cancer	0.2	0.2	0.7	-0.5	0.2	0.1	-0.8	-0.4	-0.6
Fasting Glucose	0.2	0.2	0.8	0.3	-0.6	-0.2	0.0	-0.9	0.0
Systolic Blood Pressure	0.2	1.1	2.2	1.2	1.5	0.7	0.4	1.4	0.0
Allergy or Eczema	0.2	0.5	1.1	-0.5	0.8	0.6	-0.5	0.6	-1.1
Hearing difficulty/problems: Yes	0.2	0.2	0.9	0.2	-0.1	-0.3	1.0	-0.4	0.4
Age when periods started (menarche)	0.2	0.4	1.0	-0.1	1.0	0.7	-0.2	0.8	-0.5
Body mass index (BMI)	0.2	1.0	2.2	-1.5	0.2	0.3	-1.3	-1.2	-1.0
Had menopause	0.2	0.2	0.5	0.1	0.7	0.5	0.0	0.4	-0.5
Mouth/teeth dental problems	0.2	0.4	0.7	-0.4	0.4	0.8	-0.6	0.3	-0.8
Allergy	0.2	0.5	0.9	0.1	-0.9	-0.2	0.8	-0.5	0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	-0.0	0.3	0.7	-0.2	0.5	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.0	-0.4	-0.0	-0.6	-0.9	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	-0.5	0.5	-0.9	-0.2	-0.9	-0.0
Medication: Cholesterol lowering	0.2	0.4	0.5	0.7	-0.7	-0.6	0.6	0.1	0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	-0.7	-0.3	-0.3	-0.1	-0.7	-0.1
Leg fat percentage (right)	0.2	0.9	2.5	-0.5	-1.3	-0.8	-0.0	-1.6	0.4
Pulse wave peak to peak time	0.2	0.3	0.5	0.6	0.6	0.6	-0.2	0.7	-0.2
Arm fat percentage (left)	0.2	0.9	2.7	-0.9	-0.4	0.1	-1.0	-1.6	-0.8
Breast cancer (self-reported)	0.2	0.2	0.3	0.5	-0.5	-0.1	0.6	0.3	0.5
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	-0.6	-0.8	-0.3	-0.3	-0.8	-0.3
Medication: Bendroflumethiazide	0.2	0.2	1.1	-0.6	1.0	0.0	-0.2	-0.0	-0.1
Unable to work because of sickness or disability	0.2	0.2	0.6	0.2	-0.6	-0.7	0.1	-0.8	0.1
Heart disease (siblings)	0.2	0.3	0.9	0.1	0.1	-0.5	0.6	0.2	0.9
Neuroticism (Nagel 2018)	0.1	0.3	0.8	0.8	0.1	0.2	0.9	0.2	0.3
Schizophrenia (2018)	0.1	0.3	0.5	0.7	-0.6	-0.7	0.4	0.3	0.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	0.6	-0.4	0.4	0.2	0.2	-0.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.4	-0.5	-0.1	0.3	0.2	0.0
Hair Pigment	0.1	2.4	6.8	0.8	-0.5	-1.7	2.0	-0.1	2.6
Average weekly spirits intake	0.1	0.1	0.2	-0.5	0.2	-0.0	-0.1	-0.3	-0.3
Relative age of first facial hair	0.1	0.3	0.7	-0.1	0.6	0.8	-0.4	-0.0	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.5	-0.0	-0.2	-0.2	-0.1	-0.7	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.0	0.7	0.2	-0.5	0.5	-0.7
Medication: Atenolol	0.1	0.1	0.3	-0.1	-0.3	-0.5	-0.0	0.1	0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.5	0.2	0.2	-0.3	-0.4	-0.4
Financial difficulties in last 2 years	0.1	0.2	0.4	-0.6	0.5	0.3	-0.2	-0.5	-0.2
Pain all over the body in last month	0.1	0.1	0.2	-0.0	0.4	-0.0	-0.3	0.1	-0.5
Medication: Simvastatin	0.1	0.1	0.3	-0.1	-0.2	-0.3	-0.1	-0.5	-0.1
Neuroticism score	0.1	0.2	0.7	-0.3	-0.4	-0.3	0.1	-0.8	-0.0
Arm fat percentage (right)	0.1	0.4	1.8	-0.4	-0.4	-0.1	-0.5	-1.3	-0.4
Happiness	0.1	0.2	0.6	0.1	0.8	0.6	-0.2	-0.3	-0.3
Depression (self-reported)	0.1	0.1	0.3	0.1	-0.6	-0.4	0.1	-0.3	0.1
Lung cancer (father)	0.1	0.1	0.2	-0.1	0.0	-0.5	0.3	-0.1	0.4
Pulse wave reflection index	0.1	0.1	0.2	0.2	-0.3	-0.4	0.2	0.2	0.3
Blood clot in the leg (DVT)	0.1	0.2	0.4	0.1	0.2	0.4	-0.1	0.6	-0.7
Medication: Blood pressure	0.1	0.2	0.5	-0.6	0.5	-0.2	-0.1	-0.7	0.2
Had major operations	0.1	0.1	0.3	-0.4	-0.5	-0.6	-0.1	-0.4	-0.1
Mood swings	0.1	0.2	0.6	-0.1	-0.5	-0.8	0.4	-0.5	0.4
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.2	-0.4	-0.1	0.3	-0.5	0.3
Number of operations (self-reported)	0.1	0.1	0.4	0.4	0.3	0.1	0.4	0.1	0.6
Commuting to job workplace: Cycle	0.1	0.1	0.3	-0.2	0.2	-0.5	-0.4	-0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.7	0.3	0.1	0.2	0.2	0.8	-0.3
Neuroticism	0.0	0.1	0.2	0.3	0.0	0.5	0.1	-0.1	-0.4
Tanning	0.0	0.5	1.4	-0.3	-0.6	-0.7	-0.6	-1.2	0.1
Sensitivity / hurt feelings	0.0	0.0	0.1	0.3	-0.2	-0.1	0.0	-0.2	-0.3
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.1	0.1	0.2	-0.3	0.1	-0.2

Hub : Genes

PAFAH2

Models

Trait associations