Hub : Genes

PAIP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0420 0.0170 4.4e-05 0.054 0.022 0.051 0.02 0.050 3.5e-07 0.00083 6.7e-07 0.0014 9.4e-07
2 GTEx Brain Cerebellar Hemisphere 0.2880 0.1090 1.4e-04 0.158 NA 0.215 NA 0.176 7.3e-05 NA 3.2e-06 NA 2.8e-05
3 GTEx Brain Frontal Cortex BA9 0.1261 0.0606 4.9e-03 -0.006 NA 0.018 NA -0.005 5.2e-01 NA 1.1e-01 NA 4.7e-01
4 GTEx Uterus 0.2840 0.1300 7.3e-03 -0.015 NA 0.015 NA -0.006 9.7e-01 NA 1.6e-01 NA 4.4e-01
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0212 0.0159 5.7e-03 0.032 0.015 0.022 NA 0.030 1.3e-04 0.00680 1.5e-03 NA 2.5e-04
6 TCGA Uterine Corpus Endometrial Carcinoma 0.4410 0.1680 5.5e-03 -0.005 0.025 0.023 NA 0.044 4.6e-01 0.06600 7.7e-02 NA 2.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.2 0.5 -0.2 0.7 -0.4 -0.7 -0.1 -0.5
Bipolar Disorder or Schizophrenia 0.3 0.8 2.5 -1.0 1.6 0.5 0.7 -0.9 0.5
Depressed Affect (Nagel 2018) 0.6 1.3 2.8 1.4 -1.1 -0.4 1.7 1.0 0.7
Depression (Nagel 2018) 1.0 1.4 4.0 1.5 -0.3 -0.6 2.0 1.0 0.9
Intelligence (Savage-Jansen 2018) 1.1 3.5 6.2 -2.5 1.7 1.7 0.8 -2.4 1.4
Neuroticism (Nagel 2018) 0.2 0.6 1.2 0.7 -1.0 -0.1 1.1 0.6 0.5
Schizophrenia (2018) 0.7 1.4 2.1 -1.1 1.4 1.1 1.5 -1.0 1.0
Schizophrenia vs Biploar Disorder 1.1 1.4 2.5 -1.4 1.6 1.4 0.3 -1.2 0.7
Worry (Nagel 2018) 0.1 0.2 0.4 -0.3 -0.6 0.1 0.7 -0.3 0.5
Alzheimer’s Disease (in mother) 1.5 1.8 5.3 -1.4 0.2 0.9 -2.3 -1.3 0.8
Alzheimer’s Disease (in father) 0.7 0.8 1.5 -1.2 0.9 1.0 -0.8 -0.9 -0.1
Alzheimer’s Disease (including proxy) 2.0 2.8 6.9 -2.1 0.5 1.0 -2.6 -1.8 1.2
Crohns Disease (2017) 0.4 1.0 2.9 -0.1 -0.4 1.6 -0.5 -0.1 -1.7
Irritable Bowel Disease (IBD) 0.6 1.4 3.1 -1.3 1.0 1.8 -0.8 -1.3 -0.5
Ulcerative Colitis (UC) 0.5 1.0 1.7 -1.3 1.3 0.9 -0.2 -1.3 0.4
Major Depression (MDD) 1.0 1.2 5.6 0.2 1.1 0.6 2.4 0.1 0.0
Reaction Time 0.7 1.4 2.6 -0.7 1.6 1.0 1.6 -0.6 -1.3
Verbal and Numeric Reasoning (VNR) 1.5 3.5 6.0 -2.4 1.7 1.9 0.7 -2.4 1.6
Breast Cancer 1.8 4.3 7.0 2.5 -1.3 -2.3 2.6 2.2 -0.7
Ovarian Cancer 0.2 0.3 0.6 -0.8 0.4 0.2 -0.4 -0.7 0.6
Prostate Cancer 3.2 4.5 6.7 1.7 -2.5 -2.6 -2.2 1.8 -1.7
Age at First Birth 0.9 1.3 4.0 -1.1 0.0 -0.1 -2.0 -1.1 1.1
Bipolar Disorder (2011) 1.4 1.4 2.2 -1.5 1.3 1.2 -0.8 -1.4 0.4
Body Mass Index (BMI) (2010) 0.5 0.7 3.3 -0.2 -0.2 0.7 1.8 -0.2 0.1
Coronary Artery Disease (CAD) 0.6 0.7 1.6 0.6 -1.2 -0.7 -0.5 0.3 1.2
Crohns Disease (2012) 0.3 0.5 2.0 0.0 -0.6 0.7 0.0 -0.0 -1.4
Mean Putamen Volume 1.9 2.1 4.3 2.1 -1.5 -1.2 1.4 1.7 -0.2
Fasting Glucose 2.1 2.5 4.0 1.7 -1.8 -2.0 -1.0 1.9 -0.4
HbA1C 1.6 1.7 3.3 -1.8 0.5 0.8 -0.5 -1.7 1.7
HDL Cholesterol 0.9 1.6 2.2 -1.3 1.3 1.4 -1.5 -1.2 0.6
LDL Cholesterol 0.2 0.3 1.3 0.1 -0.1 -0.4 -1.1 0.3 0.1
Lupus 0.3 0.4 1.6 0.1 -0.5 0.7 1.3 -0.1 -0.4
Neuroticism (2016) 1.2 1.8 3.8 1.4 -1.1 -2.0 1.5 1.2 0.3
Primary Biliary Cirrhosis 0.7 0.9 2.0 -1.0 1.4 0.7 -0.8 -0.7 -1.0
Rheumatoid Arthritis 0.4 0.6 1.3 1.1 -0.7 0.2 0.2 1.1 -0.7
Schizophrenia (2014) 0.3 0.6 1.7 -0.7 1.3 0.6 0.4 -0.6 0.4
Triglycerides 0.6 1.0 2.3 0.8 -1.4 -1.5 0.5 0.7 0.7
Type 2 Diabetes (T2D) (2012) 0.6 0.6 1.3 1.0 -1.1 0.7 -0.2 0.9 -0.4
Ulcerative Colitis 1.0 1.4 2.3 -1.5 1.5 0.8 -0.2 -1.5 0.9
Blood Eosinophil Count 1.4 10.5 15.6 -3.9 3.9 1.6 0.0 -4.0 3.8
Blood Platelet Count 0.0 0.2 0.3 -0.4 -0.3 -0.4 -0.4 -0.5 0.5
Blood Red Count 0.1 0.8 2.2 0.6 -1.5 -0.7 1.2 0.4 -0.5
Blood White Count 0.9 7.0 16.5 -2.9 4.1 1.3 0.6 -2.9 2.6
Heel T-Score 0.2 1.6 7.6 0.3 -0.5 -2.8 0.4 0.3 1.1
BMI 0.4 2.1 4.7 -0.2 0.9 2.2 2.1 -0.3 1.5
Height 0.5 9.8 22.0 -3.3 -0.8 3.6 -4.7 -3.2 1.4
Waist Hip Ratio (WHR) 0.2 0.8 2.1 1.0 -1.4 -0.8 0.4 0.9 0.2
Systolic Blood Pressure 0.4 2.0 5.4 1.1 -2.3 -0.4 1.0 0.9 -1.9
Smoking Status 3.3 8.0 11.9 3.4 -3.2 -2.8 1.1 3.2 -2.4
Allergy or Eczema 0.7 1.8 8.0 -0.8 0.0 2.8 -0.5 -0.9 0.9
Cardiovascular Disease 0.6 2.0 3.9 1.6 -2.0 0.1 0.9 1.4 -1.5
Hypothyroidism (self reported) 2.3 5.4 7.4 -2.5 2.5 2.7 0.1 -2.5 2.5
Respiratory disease 0.8 1.7 8.0 -0.1 0.9 2.8 -0.6 -0.3 -1.1
Type 2 Diabetes (T2D) (2018) 0.9 1.6 4.7 0.2 0.1 1.6 2.2 -0.1 1.5
Lung FEV1/FVC ratio 1.8 9.4 29.8 2.7 -3.3 -5.5 0.2 2.6 -1.2
Lung FVC 5.0 25.3 49.4 5.6 -4.9 -7.0 1.3 5.4 -4.1
Neuroticism 0.2 0.6 2.4 0.4 -0.5 0.7 1.6 0.1 -0.1
Chronotype (morning person) 3.0 6.9 10.7 2.9 -2.8 -3.3 2.6 2.9 0.1
Hair Pigment 0.1 3.6 8.0 -2.4 2.8 1.6 -0.1 -2.2 0.4
Tanning 0.2 2.4 5.9 1.5 -1.8 -2.4 -0.4 1.6 -0.3
Hand grip strength (left) 1.0 2.7 3.9 2.0 -1.9 -1.4 -1.5 2.0 -1.0
Number of treatments/medications taken 0.4 0.7 2.0 0.9 -1.4 0.6 0.3 0.6 0.6
Average weekly spirits intake 0.7 0.8 1.5 -1.0 1.0 0.8 -0.4 -1.2 0.8
Sensitivity / hurt feelings 0.5 0.8 2.8 -0.7 1.7 -0.2 0.4 -0.9 0.7
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.8 -0.0 -0.2 0.5 0.2 -0.4 1.4
Hearing difficulty/problems: Yes 0.5 0.7 2.1 -0.6 0.6 -1.5 -0.2 -0.8 0.9
Relative age of first facial hair 0.5 1.0 1.8 -1.3 0.8 -0.9 -0.2 -1.3 1.0
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 1.7 -1.3 1.1 0.0 -0.6 -1.3 1.1
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.0 -0.3 0.7 1.4 0.9 -0.4 0.4
Ever had hysterectomy (womb removed) 0.5 0.6 1.8 0.6 -0.7 0.6 1.3 0.3 0.5
Systolic blood pressure, automated reading 1.2 3.4 8.7 1.5 -1.3 0.8 2.9 1.2 -2.4
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.2 0.5 -1.2 1.5 -0.9 0.5 -1.1
Angina 0.6 0.7 2.0 -0.0 1.4 1.4 0.7 -0.2 -0.0
Medication for hormone replacement therapy 0.2 0.2 0.6 -0.5 -0.2 -0.0 0.3 -0.5 0.8
Vitamin and mineral supplements 0.6 0.8 2.7 0.3 -0.7 0.9 0.6 0.3 -1.6
Supplements: Zinc 2.1 2.3 6.5 -1.6 1.0 -0.4 -2.6 -1.5 1.1
Medication: Co-codamol 0.3 0.4 1.3 -0.6 0.3 0.2 -0.2 -0.8 1.1
Medication: Metformin 0.5 0.7 1.8 0.1 -0.4 1.3 1.3 -0.1 0.7
Diabetes (father) 2.0 2.5 4.0 1.8 -2.0 -0.3 1.9 1.8 0.7
Diabetes (mother) 2.8 3.6 5.6 2.2 -2.1 -2.4 1.4 2.1 -0.0
Severe depression (siblings) 0.8 0.9 2.4 0.2 -1.1 -1.5 -1.3 0.1 0.5
Pack years adult smoking proportion 2.6 4.0 7.5 2.7 -2.1 -1.7 1.5 2.5 -0.6
Impedance of leg (right) 1.5 7.4 14.6 3.0 -3.8 -2.5 0.6 3.2 -2.0
Leg fat-free mass (left) 0.9 4.9 7.3 -2.6 1.6 2.4 -1.6 -2.7 2.1
Trunk fat percentage 0.6 2.5 9.3 1.0 -1.4 1.4 3.0 0.7 0.6
Hand grip strength (right) 0.4 1.0 2.3 0.9 -1.3 -0.6 -1.5 0.9 -0.3
Townsend deprivation index at recruitment 0.4 0.6 1.3 1.1 -0.5 -0.9 -0.1 1.1 -0.3
Current tobacco smoking 1.9 3.1 4.4 2.1 -1.2 -1.5 1.5 2.0 -2.1
Average weekly fortified wine intake 1.3 1.5 3.7 -1.2 1.9 1.5 0.3 -1.2 -0.1
Maternal smoking around birth 1.9 2.8 3.4 1.8 -1.7 -1.9 1.4 1.8 -1.5
Fed-up feelings 0.6 1.0 2.3 0.9 -1.5 -0.5 1.4 0.6 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.6 4.7 2.2 -1.1 -1.6 1.8 1.9 -0.1
Relative age voice broke 0.6 0.9 1.6 -1.2 1.3 -0.2 0.5 -1.2 -1.0
Taking other prescription medications 1.7 2.7 8.1 1.7 -1.6 0.9 2.8 1.2 -0.6
Age when periods started (menarche) 0.5 1.1 4.5 0.8 0.7 -2.1 -0.6 1.0 -0.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.3 0.9 -0.4 -1.1 0.5 0.8 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.9 -0.5 0.7 -0.6 0.3 -0.5 0.9
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.7 -0.1 0.2 1.3 -0.7 -0.3 0.8
Qualifications: CSEs or equivalent 0.3 0.4 1.2 0.6 -1.1 -0.9 0.3 0.4 0.2
Serious illness, injury or assault to yourself 0.8 0.9 2.4 -0.4 1.2 -1.0 -0.3 -0.5 1.6
High blood pressure 0.7 1.9 5.0 1.1 -2.2 0.8 2.0 0.9 0.1
Hayfever, allergic rhinitis or eczema 0.6 1.3 3.2 -0.7 -0.9 1.8 -1.5 -0.5 0.8
Multivitamins +/- minerals 2.5 3.2 5.9 -2.1 2.4 0.2 -0.2 -2.0 2.3
Stomach or abdominal pain in last month 0.1 0.1 0.6 0.0 -0.1 0.0 0.1 0.0 0.8
Supplements: Glucosamine 2.6 3.3 5.5 -2.3 2.3 -0.3 0.3 -2.4 1.9
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.5 -0.8 -0.0 -0.1 -1.2 -0.8 0.2
Medication: Atenolol 0.1 0.1 0.3 -0.1 -0.2 0.5 -0.3 -0.3 0.2
Medication: Levothyroxine sodium 0.5 0.8 1.5 -0.9 1.1 1.2 0.1 -0.8 0.9
Sitting height 0.2 1.6 2.6 -1.4 -1.1 0.7 -1.6 -1.4 1.1
Chronic bronchitis/emphysema (father) 0.8 0.9 2.6 -0.9 1.6 0.1 -0.6 -1.1 0.8
High blood pressure (mother) 0.1 0.1 0.5 0.2 -0.3 -0.7 -0.1 0.2 -0.0
Body mass index (BMI) 0.5 2.0 5.2 -0.2 1.0 2.1 2.3 -0.5 1.1
Impedance of leg (left) 1.5 7.4 15.3 3.0 -3.9 -2.2 1.2 3.2 -2.0
Leg predicted mass (left) 0.9 5.0 7.5 -2.6 1.6 2.4 -1.6 -2.7 2.1
Trunk fat mass 0.3 1.5 4.1 0.2 -0.9 1.8 2.0 -0.1 1.0
Waist circumference 0.4 1.5 3.2 -0.5 0.3 1.8 1.6 -0.7 1.6
Number of incorrect matches in round 0.4 0.7 1.7 0.1 -0.8 -0.8 -1.1 0.0 -1.3
Past tobacco smoking 1.3 2.4 4.6 -1.9 2.1 1.3 -0.4 -1.9 0.8
Alcohol usually taken with meals 1.6 2.6 12.1 -0.8 0.5 -1.2 -3.5 -0.9 0.4
Nervous feelings 1.0 1.8 3.2 -1.8 1.1 1.8 -0.6 -1.7 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.1 0.8 -0.8 -1.0 1.4 0.5 -0.3
Hearing difficulty/problems with background noise 0.3 0.5 1.9 0.2 -0.6 -1.4 -0.7 0.1 -0.2
Hair/balding pattern: Pattern 2 0.7 0.9 3.3 0.7 -0.8 0.8 1.8 0.6 -0.5
Had menopause 1.1 1.3 3.7 -1.0 1.3 1.9 0.1 -1.1 0.5
Had other major operations 0.9 1.1 3.2 1.2 -0.5 -1.8 -0.3 1.1 -0.5
Forced vital capacity (FVC) 1.6 6.0 11.8 2.4 -3.4 -3.0 -0.4 2.3 -2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 4.3 -0.9 1.4 -0.2 0.3 -0.9 2.1
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 3.1 1.6 -1.4 -0.2 0.0 1.7 -1.8
Qualifications: None of the above 2.1 4.4 9.5 2.5 -1.3 -0.8 3.1 2.3 -1.8
Financial difficulties in last 2 years 2.7 3.6 5.3 1.6 -2.3 -2.1 -1.8 1.9 -1.5
Mouth/teeth dental problems 4.3 6.6 12.3 -3.5 1.9 1.2 -1.2 -3.4 3.1
Heart attack 0.5 0.7 1.8 1.1 -1.3 0.3 0.2 1.0 0.0
Allergy 0.5 1.2 5.1 0.1 0.8 -2.2 1.1 -0.0 -0.3
Pain all over the body in last month 0.3 0.3 1.4 0.2 0.1 -1.2 0.3 0.4 0.4
Diabetes (self-reported) 1.3 2.0 6.0 -0.2 0.3 2.4 1.8 -0.3 1.6
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.5 0.4 -1.2 1.1 -1.2 0.5 -0.4
Medication: Ramipril 0.6 0.8 3.1 0.3 -1.1 1.8 -0.5 0.2 0.4
Medication: Simvastatin 0.6 0.9 2.1 1.1 -1.4 0.2 0.8 1.0 -0.6
Fluid intelligence score 1.7 3.6 5.9 -2.4 1.6 2.1 1.3 -2.4 1.2
Illnesses of siblings 0.5 0.6 2.1 0.5 -0.6 -1.4 0.7 0.5 0.6
Neuroticism score 0.2 0.5 2.3 -0.1 0.2 0.1 1.5 -0.4 0.6
Weight 0.5 2.4 7.0 -1.3 0.6 2.6 0.3 -1.5 1.7
Impedance of arm (right) 1.1 5.0 11.7 2.1 -3.4 -2.7 0.2 2.2 -1.2
Arm fat percentage (right) 0.4 1.6 7.0 0.8 -0.6 1.0 2.7 0.5 0.6
Trunk fat-free mass 1.4 8.2 11.8 -3.4 2.0 2.5 -3.4 -3.4 2.0
Hip circumference 0.4 1.6 4.5 -1.3 0.5 2.1 0.3 -1.4 1.2
Time employed in main current job 0.7 0.8 1.8 1.3 -1.1 -0.6 0.1 1.2 -0.4
Alcohol intake versus 10 years previously 0.9 1.3 3.1 0.6 -0.9 -1.6 -1.8 0.7 -0.8
Father’s age at death 1.2 1.6 5.7 0.9 -1.5 -0.0 -0.1 1.0 -2.4
Worrier / anxious feelings 0.4 0.7 1.7 0.9 -1.0 -1.3 0.1 0.8 0.1
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.7 3.4 1.7 -0.8 -1.1 1.8 1.5 0.1
Falls in the last year 0.3 0.4 1.7 0.4 -0.0 -0.1 1.3 0.4 0.4
Hair/balding pattern: Pattern 3 0.5 0.8 2.8 -0.5 0.9 -1.7 0.7 -0.5 0.1
Number of live births 0.8 1.2 2.6 1.5 0.1 -1.1 0.3 1.6 -1.0
Forced expiratory volume in 1-second (FEV1) 2.5 8.6 16.2 2.7 -3.9 -4.0 -0.6 2.7 -2.3
Pulse rate 0.4 0.6 1.9 -0.7 1.4 0.4 -0.9 -0.6 0.2
Happiness 0.4 0.4 2.4 0.3 0.1 1.5 0.4 0.2 0.1
Noisy workplace 4.5 5.6 9.6 2.7 -3.1 -2.5 0.7 2.5 -1.9
Qualifications: A levels/AS levels or equivalent 2.0 4.3 13.6 -2.2 1.8 0.0 -3.7 -2.0 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.5 0.5 -0.7 -0.0 -0.3 0.6 0.2
Mouth/teeth dental problems: Dentures 1.1 1.8 4.8 1.8 -0.2 -0.4 2.2 1.5 -0.6
Asthma 0.6 1.1 5.6 -0.5 0.7 2.4 -0.1 -0.3 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 2.8 1.3 -1.7 -0.9 -0.3 1.1 0.7
Medication: Cholesterol lowering 0.8 1.3 4.2 0.9 -2.0 0.8 1.2 0.7 0.0
Depression (self-reported) 0.8 1.0 3.7 0.9 -1.9 -0.3 0.6 0.9 -0.4
Medication: Lansoprazole 0.3 0.3 0.7 0.8 -0.5 0.2 -0.3 0.8 -0.5
Prospective memory result 0.3 0.4 1.7 -0.4 -0.4 0.3 -0.4 -0.5 1.3
Lung cancer (father) 1.4 1.6 6.0 1.0 -1.0 -2.5 -0.6 1.1 0.1
Illnesses of mother 0.2 0.2 0.6 -0.2 -0.7 -0.8 -0.5 -0.1 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 3.7 11.7 20.4 3.3 -4.0 -4.5 -1.1 3.2 -3.3
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 -0.5 0.2 0.5 0.1 -0.6 0.6
Impedance of arm (left) 0.7 3.2 8.3 1.6 -2.9 -1.9 1.0 1.6 -1.1
Arm fat mass (right) 0.3 1.1 3.2 0.0 -0.1 1.5 1.8 -0.3 1.0
Trunk predicted mass 1.5 8.5 12.2 -3.5 2.0 2.5 -3.5 -3.5 2.0
Standing height 0.6 5.5 16.9 -2.5 -0.7 1.5 -4.1 -2.4 1.3
Length of working week for main job 0.1 0.1 0.3 0.4 0.1 0.5 0.1 0.4 0.5
Exposure to tobacco smoke at home 0.5 0.5 1.7 -0.5 1.3 -0.8 -0.4 -0.7 -0.3
Breastfed as a baby 0.3 0.3 1.0 0.5 -0.2 1.0 0.7 0.2 0.2
Tense / ‘highly strung’ 0.8 1.3 3.1 1.1 -1.8 -0.4 1.0 1.0 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.6 4.9 2.2 -1.9 -1.1 -0.2 2.1 -1.2
Hair/balding pattern: Pattern 4 0.6 1.4 3.1 -0.6 1.3 1.5 -1.8 -0.6 -0.6
Birth weight of first child 1.2 2.1 4.0 -1.5 2.0 0.7 -1.2 -1.5 1.4
Peak expiratory flow (PEF) 2.2 5.1 10.8 2.3 -2.5 -3.3 -0.7 2.5 -1.4
Pulse wave reflection index 1.9 2.3 5.3 -1.7 1.3 0.9 0.3 -1.8 2.3
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.5 0.6 -0.0 -0.2 0.7 0.4 -0.1
Loud music exposure frequency 1.4 1.5 4.0 1.3 -2.0 -0.4 0.7 1.2 -1.0
Qualifications: O levels/GCSEs or equivalent 3.7 5.8 21.1 -2.3 1.2 -1.4 -4.6 -2.1 1.0
Mouth/teeth dental problems: Bleeding gums 2.2 2.9 4.9 2.2 -2.0 -0.1 0.8 2.1 -1.9
Blood clot in the leg (DVT) 0.9 1.2 2.4 1.6 -1.0 -0.7 0.8 1.5 -0.4
Medication: Paracetamol 1.4 2.3 4.1 1.9 -1.1 -1.2 -2.0 1.8 -0.4
Headache pain in last month 1.5 2.6 4.9 2.2 -1.2 -2.0 -0.0 2.1 -1.0
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 4.1 -0.6 2.0 -0.1 -0.8 -0.4 -0.1
Glaucoma (self-reported) 2.4 2.8 6.2 2.5 -1.2 -0.3 1.3 2.2 -1.5
Gout (self-reported) 0.4 0.6 2.8 0.4 -1.7 0.3 0.7 0.2 0.2
Hypothyroidism/myxoedema (self-reported) 1.5 2.9 4.4 -1.7 1.9 2.1 -0.5 -1.7 1.9
Medication: Amlodipine 1.3 1.9 3.8 1.9 -0.7 0.2 1.2 1.8 -1.5
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.2 -1.0 0.7 1.5 -0.8 -0.9 0.8
Birth weight 1.7 3.7 12.0 -2.0 3.5 -0.1 -1.3 -1.9 0.7
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.4 0.2 0.2 -1.6 -1.5 0.4 -0.1
High blood pressure (siblings) 0.6 0.8 1.4 -1.0 -0.2 1.0 -1.1 -1.2 0.5
Forced vital capacity (FVC), Best measure 2.0 7.2 11.0 2.7 -3.3 -3.0 -0.9 2.5 -2.9
Body fat percentage 0.8 3.1 11.7 1.4 -1.4 1.3 3.4 1.1 0.3
Leg fat percentage (right) 0.8 3.0 10.6 1.6 -0.8 1.5 3.2 1.4 -0.2
Arm fat-free mass (right) 1.1 5.5 7.8 -2.8 1.7 2.8 -1.7 -2.8 2.0
Exposure to tobacco smoke outside home 1.0 1.3 3.0 -0.5 1.7 -1.1 0.6 -0.5 1.6
Comparative body size at age 10 4.3 11.9 16.4 -3.9 4.0 3.5 1.9 -3.7 3.2
Number of full brothers 0.5 0.6 1.0 -0.9 0.7 -0.3 -1.0 -0.7 1.0
Worry too long after embarrassment 1.6 2.7 5.1 -1.9 2.3 1.0 0.1 -1.9 1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.0 -0.2 0.3 -0.5 -1.0 -0.2 -0.7
Wheeze or whistling in the chest in last year 1.0 1.7 2.5 1.5 -1.3 1.4 0.4 1.6 -1.4
Number of children fathered 1.7 1.9 3.7 -1.0 1.9 1.4 1.4 -1.2 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.6 -0.6 -0.3 1.3 -0.2 -0.5 0.3
Age at first live birth 1.8 3.2 8.1 -2.2 0.7 1.4 -2.8 -1.9 0.7
Pulse wave peak to peak time 0.0 0.0 0.1 0.1 0.0 -0.1 -0.3 0.2 -0.4
Health satisfaction 0.4 0.6 1.1 1.0 -0.5 -0.8 0.3 0.9 -0.7
Shortness of breath walking on level ground 2.1 2.5 4.6 -1.9 1.1 1.2 -0.4 -2.0 2.1
Qualifications: College or University degree 1.0 3.0 5.9 -2.4 1.5 1.1 -1.8 -2.2 1.0
Eye problems/disorders: None of the above 4.5 5.2 8.5 -2.9 2.7 1.5 -0.2 -2.8 2.4
Mouth/teeth dental problems: Loose teeth 4.1 4.9 8.3 2.4 -1.6 -0.3 2.9 2.4 -2.6
Emphysema/chronic bronchitis 0.4 0.5 1.8 0.6 -0.1 0.6 -0.5 0.4 -1.3
Medication for pain relief, constipation, heartburn 1.4 2.4 5.3 -2.1 2.3 1.2 0.5 -1.7 -0.2
Neck or shoulder pain in last month 3.1 4.3 8.8 2.2 -2.0 -3.0 0.2 2.0 -2.0
Medication: Blood pressure 0.3 0.6 2.1 0.6 -1.4 -0.2 0.9 0.4 0.3
Angina (self-reported) 0.6 0.7 2.2 0.0 1.5 1.3 0.7 -0.1 -0.1
Migraine (self-reported) 5.4 6.7 11.1 3.2 -2.7 -3.3 0.7 3.1 -1.2
Medication: Ibuprofen 1.2 1.5 3.9 1.4 -2.0 -1.0 -0.5 1.2 -0.2
Medication: Allopurinol 0.2 0.2 0.8 0.2 -0.5 0.6 0.9 0.0 0.0
Medication: Omeprazole 0.5 0.6 1.4 -0.1 -1.1 -0.5 -1.2 -0.1 0.8
Medication: Seretide 50 evohaler 0.6 0.7 1.2 1.1 -1.0 0.1 -0.7 0.9 -0.7
Mean time to correctly identify matches 1.0 1.8 3.1 -0.3 1.6 1.8 1.7 -0.4 -1.5
Heart disease (mother) 0.1 0.1 0.3 0.4 -0.2 0.6 0.1 0.2 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.5 0.1 0.6 -0.7 -0.7 0.3 -0.1
Whole body fat mass 0.3 1.3 3.8 0.4 -0.7 1.7 1.9 0.1 0.9
Leg fat mass (right) 0.5 1.9 5.6 0.7 -0.6 2.0 2.4 0.5 0.5
Arm predicted mass (right) 1.0 5.1 7.5 -2.6 1.8 2.5 -1.6 -2.7 2.0
Pulse rate, automated reading 0.9 2.8 9.1 -1.1 3.0 2.1 1.1 -1.0 -0.3
Alcohol intake frequency. 0.8 1.9 3.7 1.9 -0.7 -0.8 -0.8 1.9 -1.6
Comparative height size at age 10 0.5 2.5 5.4 -1.6 -0.6 1.7 -2.3 -1.6 1.2
Number of full sisters 0.3 0.3 0.6 0.2 -0.7 -0.4 -0.8 0.3 -0.8
Suffer from ‘nerves’ 0.7 1.2 2.4 -0.9 1.6 0.9 1.5 -0.8 -0.2
Overall health rating 0.6 1.4 2.8 1.7 -1.2 0.2 1.4 1.5 0.0
Chest pain or discomfort 0.9 1.3 2.9 1.7 -0.9 -0.9 0.7 1.3 -1.0
Had major operations 0.4 0.5 1.6 0.1 -0.4 -0.8 -0.5 -0.1 1.3
Age at last live birth 0.8 1.2 5.8 -0.0 -1.0 0.2 -2.4 0.3 -0.4
Family relationship satisfaction 0.3 0.4 1.7 0.4 -0.4 1.3 0.2 0.4 -0.1
Leg pain on walking 1.0 1.3 2.9 -1.2 1.0 0.5 -0.4 -1.4 1.7
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.8 0.6 -0.1 -0.9 0.7 0.6 0.2
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.1 0.6 -0.7 -0.0 -0.1 0.4 1.0
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.8 -1.3 1.2 0.4 0.6 -1.3 0.7
Medication: Aspirin 1.2 1.6 3.4 1.8 -0.9 0.4 1.3 1.5 -1.1
Supplements: Vitamin C 0.6 0.7 1.4 0.5 -0.7 -1.2 -1.1 0.5 0.9
Knee pain experienced in last month 0.4 0.6 1.5 1.2 -0.5 -0.5 0.5 1.1 -0.5
Hypertension (Self-reported) 0.7 2.0 4.5 1.2 -1.8 1.3 2.1 1.0 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 0.1 -0.4 0.5 0.4 0.0 0.1
Illnesses of father: Heart disease 1.6 2.2 6.7 1.4 -0.3 1.4 2.6 1.4 -0.7
Illnesses of siblings: Diabetes 0.1 0.2 0.4 0.4 0.3 0.4 -0.0 0.6 -0.5
Smoking status: Previous 0.8 1.1 3.3 1.2 -1.8 -0.8 -0.1 1.2 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.8 5.8 -1.6 -0.4 0.1 -2.4 -1.4 0.1
Whole body fat-free mass 1.2 6.7 9.8 -3.1 1.8 2.6 -2.6 -3.1 2.0
Leg fat-free mass (right) 1.2 6.3 9.7 -3.0 2.0 2.6 -1.7 -3.1 2.3
Arm fat percentage (left) 0.5 2.1 10.0 0.6 -0.2 1.3 3.2 0.3 0.8
Average weekly red wine intake 0.2 0.3 0.5 0.5 -0.2 0.3 -0.6 0.6 -0.7
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.3 0.4 -0.4 -0.6 -1.2 0.5 -0.1
Mood swings 0.3 0.5 1.4 1.0 -1.2 -0.4 0.3 0.8 0.2
Loneliness, isolation 0.9 1.3 4.5 -1.0 0.6 -0.4 0.7 -1.2 2.1
Long-standing illness, disability or infirmity 1.5 2.2 4.8 2.2 -1.7 0.2 1.0 1.9 -1.2
Ever had bowel cancer screening 0.2 0.2 0.9 0.2 -0.3 0.3 0.9 0.1 0.1
Diabetes diagnosed by doctor 1.3 2.2 5.0 0.1 0.5 2.2 2.0 -0.2 2.0
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.4 0.5 -0.7 -0.8 1.2 0.4 -0.5
Friendships satisfaction 0.4 0.5 1.2 -0.6 -0.2 0.0 -1.0 -0.8 1.1
Qualifications: nursing, teaching 3.4 5.3 19.7 -2.0 0.9 0.3 -4.4 -1.9 1.8
Commuting to job workplace: Walk 2.1 2.2 4.2 1.1 -1.0 -1.9 1.5 1.2 -2.0
Eye problems/disorders: Cataract 2.5 2.9 5.1 2.0 -1.1 -2.3 0.5 1.9 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 2.4 0.7 -0.7 -1.1 -1.2 1.0 -1.6
Medication for cholesterol 0.2 0.4 0.6 -0.6 0.2 -0.8 -0.7 -0.6 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.1 1.5 -1.3 -0.0 0.3 1.4 -1.3
Back pain experienced in last month 1.6 2.4 4.8 1.7 -2.2 0.9 1.9 1.5 -0.4
Mineral and other dietary supplements 1.0 1.3 4.0 1.2 -2.0 -0.1 0.0 1.2 -1.1
Breast cancer (self-reported) 0.7 0.9 2.2 -0.7 1.1 -0.1 -1.0 -0.6 -1.5
Asthma (self-reported) 0.4 0.8 4.4 -0.2 0.3 2.1 -0.1 -0.1 0.2
Osteoporosis (self-reported) 1.0 1.3 2.2 1.0 -1.3 -1.3 -0.4 1.0 -1.5
Osteoarthritis (self-reported) 0.4 0.5 1.0 0.7 -1.0 -0.8 0.2 0.7 -0.6
Medication: Aspirin 0.6 0.8 1.8 1.3 -0.6 0.5 1.2 1.1 -0.3
Medication: Gliclazide 0.8 0.9 3.7 0.6 -0.1 1.9 1.0 0.5 -0.0
Illnesses of father: None of the above (group 1) 1.2 1.5 6.5 0.3 -1.4 -2.5 -0.5 0.3 0.4
Smoking status: Current 1.9 3.0 5.8 2.0 -0.9 -1.8 1.1 1.8 -2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 5.1 10.8 16.1 3.8 -3.4 -4.0 0.8 3.6 -3.0
Whole body water mass 1.2 6.9 10.2 -3.1 1.9 2.5 -2.6 -3.2 2.1
Leg predicted mass (right) 1.1 6.0 9.4 -3.0 1.9 2.6 -1.7 -3.1 2.2
Arm fat mass (left) 0.3 1.4 3.6 -0.2 0.2 1.9 1.9 -0.5 1.1
Number of self-reported non-cancer illnesses 2.8 4.9 13.7 2.6 -3.7 -0.0 0.4 2.4 -1.8
Average weekly champagne plus white wine intake 0.5 0.7 2.5 -0.6 0.9 0.5 -1.6 -0.5 -0.1
Miserableness 0.4 0.8 1.5 1.1 -0.6 -0.5 1.2 1.0 -0.5
Guilty feelings 0.8 1.3 3.5 -1.3 0.2 0.5 -0.6 -1.4 1.9
Wears glasses or contact lenses 1.8 2.1 4.1 1.7 -2.0 -1.2 0.1 1.7 -1.2
Ever taken oral contraceptive pill 0.4 0.4 0.6 0.5 -0.8 -0.7 -0.5 0.6 0.6
Hearing aid user 0.7 0.7 2.1 -0.9 -0.3 -0.7 0.2 -1.0 1.4
Mother’s age at death 0.8 1.0 3.2 -0.5 1.8 1.3 -0.2 -0.7 0.1
Financial situation satisfaction 0.3 0.4 1.4 -0.0 -0.5 -1.2 -0.6 -0.1 0.3
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.7 -0.6 1.3 0.8 -0.5 -0.7 0.7
Commuting to job workplace: Public transport 1.0 1.2 2.2 -1.2 1.5 -0.3 -1.4 -1.2 0.1
Eye problems/disorders: Glaucoma 2.3 2.7 6.0 2.5 -1.5 -0.9 0.9 2.2 -1.3
Medication: Blood pressure 0.5 0.9 1.6 1.0 -0.7 1.3 1.2 0.9 -0.6
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.3 1.1 -0.9 0.2 0.7 0.9 -0.7
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.2 -0.5 1.8 0.1 0.2 -0.6 0.8
High cholesterol (Self-reported) 0.6 1.0 2.0 1.4 -1.1 -0.3 0.7 1.4 -0.6
Medication: Bendroflumethiazide 0.7 1.1 2.8 0.1 1.7 0.3 1.7 0.0 0.8
Medication: Paracetamol 1.3 2.0 5.1 1.7 -0.7 -1.2 -2.3 1.5 -0.2
Medication: Lisinopril 0.4 0.5 0.9 -0.5 -0.9 -1.0 -0.7 -0.5 -0.7
Medication: Atorvastatin 0.8 1.0 3.7 0.7 -0.5 1.9 0.9 0.7 0.5
Illnesses of father: High blood pressure 0.2 0.3 0.8 -0.4 -0.0 -0.6 -0.9 -0.4 -0.4
Alcohol drinker status: Never 0.5 0.6 1.9 -0.1 0.5 1.4 0.6 -0.1 -0.9
Ever smoked 1.5 2.6 4.5 2.1 -2.1 -1.4 -0.0 2.0 -0.8
Basal metabolic rate 1.0 5.3 7.8 -2.7 1.6 2.6 -1.9 -2.8 2.0
Leg fat percentage (left) 0.9 3.2 12.7 1.4 -0.7 1.7 3.6 1.2 -0.1
Arm fat-free mass (left) 1.1 5.8 8.2 -2.8 1.8 2.5 -2.2 -2.9 2.1
Number of operations (self-reported) 0.2 0.3 0.8 0.7 -0.0 -0.9 -0.0 0.7 0.5
Average weekly beer plus cider intake 0.5 0.7 1.7 0.6 -1.3 -1.2 -0.5 0.6 -0.0
Irritability 0.8 1.4 3.3 0.9 -1.8 -0.5 1.8 0.6 0.7
Risk taking 1.6 2.4 5.2 1.7 -1.2 -2.3 0.5 1.6 -1.4
Ever had prostate specific antigen (PSA) test 3.2 3.7 6.1 2.5 -2.2 -2.0 0.5 2.2 -1.2
Fractured/broken bones in last 5 years 1.5 1.9 2.9 -1.4 1.4 1.0 1.7 -1.4 1.1
Age started oral contraceptive pill 0.4 0.5 1.9 -0.5 0.2 0.6 -1.4 -0.5 -0.4
Diastolic blood pressure, automated reading 0.3 0.9 3.1 -0.6 0.6 1.0 1.8 -0.8 0.3
Ever depressed for a whole week 0.4 0.5 0.7 0.8 -0.8 -0.5 -0.7 0.8 -0.4
Unable to work because of sickness or disability 1.3 1.7 5.0 1.3 -0.8 -2.2 -0.6 1.1 -1.0
Commuting to job workplace: Cycle 0.4 0.5 1.0 -0.9 0.7 0.1 -0.7 -1.0 0.3
Myopia 1.7 2.4 4.1 -2.0 1.8 1.0 -1.3 -2.0 0.9
Vascular/heart problems diagnosed by doctor 0.8 2.3 6.2 -1.5 2.5 -0.7 -1.7 -1.3 0.6
Cholesterol lowering medication 0.3 0.4 0.8 0.5 0.3 0.9 0.9 0.5 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.6 0.7 -1.3 -1.2 -0.3 0.6 0.4
Pain experienced in last month 1.9 3.2 5.3 -2.3 2.3 2.0 0.1 -2.1 0.9
Supplements: Calcium 1.9 2.0 5.9 -1.4 1.1 -0.2 -2.4 -1.3 1.2
Basal cell carcinoma (self-reported) 3.8 4.6 7.3 2.7 -1.5 -0.6 2.3 2.6 -2.3
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.7 1.1 -1.3 0.0 0.0 0.9 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 2.8 1.7 -0.9 -0.6 0.7 1.6 -0.6
Heart disease (siblings) 0.2 0.2 0.6 0.5 0.4 0.2 -0.1 0.5 -0.8
Alcohol drinker status: Previous 0.2 0.2 0.3 0.4 -0.5 0.3 0.5 0.6 0.5
Pack years of smoking 2.3 3.4 7.1 2.7 -1.8 -1.4 1.5 2.4 -0.4
Impedance of whole body 1.3 6.8 15.0 2.7 -3.9 -2.4 1.1 2.8 -1.8
Leg fat mass (left) 0.5 1.8 5.4 0.5 -0.5 2.1 2.3 0.3 0.6
Arm predicted mass (left) 1.0 5.2 7.3 -2.6 1.9 2.3 -2.2 -2.7 1.8