Hub : Genes

PAIP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0420	0.0170	4.4e-05	0.054	0.022	0.051	0.02	0.050	3.5e-07	0.00083	6.7e-07	0.0014	9.4e-07
2	GTEx	Brain Cerebellar Hemisphere	0.2880	0.1090	1.4e-04	0.158	NA	0.215	NA	0.176	7.3e-05	NA	3.2e-06	NA	2.8e-05
3	GTEx	Brain Frontal Cortex BA9	0.1261	0.0606	4.9e-03	-0.006	NA	0.018	NA	-0.005	5.2e-01	NA	1.1e-01	NA	4.7e-01
4	GTEx	Uterus	0.2840	0.1300	7.3e-03	-0.015	NA	0.015	NA	-0.006	9.7e-01	NA	1.6e-01	NA	4.4e-01
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0212	0.0159	5.7e-03	0.032	0.015	0.022	NA	0.030	1.3e-04	0.00680	1.5e-03	NA	2.5e-04
6	TCGA	Uterine Corpus Endometrial Carcinoma	0.4410	0.1680	5.5e-03	-0.005	0.025	0.023	NA	0.044	4.6e-01	0.06600	7.7e-02	NA	2.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.2	0.5	-0.2	0.7	-0.4	-0.7	-0.1	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.8	2.5	-1.0	1.6	0.5	0.7	-0.9	0.5
Depressed Affect (Nagel 2018)	0.6	1.3	2.8	1.4	-1.1	-0.4	1.7	1.0	0.7
Depression (Nagel 2018)	1.0	1.4	4.0	1.5	-0.3	-0.6	2.0	1.0	0.9
Intelligence (Savage-Jansen 2018)	1.1	3.5	6.2	-2.5	1.7	1.7	0.8	-2.4	1.4
Neuroticism (Nagel 2018)	0.2	0.6	1.2	0.7	-1.0	-0.1	1.1	0.6	0.5
Schizophrenia (2018)	0.7	1.4	2.1	-1.1	1.4	1.1	1.5	-1.0	1.0
Schizophrenia vs Biploar Disorder	1.1	1.4	2.5	-1.4	1.6	1.4	0.3	-1.2	0.7
Worry (Nagel 2018)	0.1	0.2	0.4	-0.3	-0.6	0.1	0.7	-0.3	0.5
Alzheimer’s Disease (in mother)	1.5	1.8	5.3	-1.4	0.2	0.9	-2.3	-1.3	0.8
Alzheimer’s Disease (in father)	0.7	0.8	1.5	-1.2	0.9	1.0	-0.8	-0.9	-0.1
Alzheimer’s Disease (including proxy)	2.0	2.8	6.9	-2.1	0.5	1.0	-2.6	-1.8	1.2
Crohns Disease (2017)	0.4	1.0	2.9	-0.1	-0.4	1.6	-0.5	-0.1	-1.7
Irritable Bowel Disease (IBD)	0.6	1.4	3.1	-1.3	1.0	1.8	-0.8	-1.3	-0.5
Ulcerative Colitis (UC)	0.5	1.0	1.7	-1.3	1.3	0.9	-0.2	-1.3	0.4
Major Depression (MDD)	1.0	1.2	5.6	0.2	1.1	0.6	2.4	0.1	0.0
Reaction Time	0.7	1.4	2.6	-0.7	1.6	1.0	1.6	-0.6	-1.3
Verbal and Numeric Reasoning (VNR)	1.5	3.5	6.0	-2.4	1.7	1.9	0.7	-2.4	1.6
Breast Cancer	1.8	4.3	7.0	2.5	-1.3	-2.3	2.6	2.2	-0.7
Ovarian Cancer	0.2	0.3	0.6	-0.8	0.4	0.2	-0.4	-0.7	0.6
Prostate Cancer	3.2	4.5	6.7	1.7	-2.5	-2.6	-2.2	1.8	-1.7
Age at First Birth	0.9	1.3	4.0	-1.1	0.0	-0.1	-2.0	-1.1	1.1
Bipolar Disorder (2011)	1.4	1.4	2.2	-1.5	1.3	1.2	-0.8	-1.4	0.4
Body Mass Index (BMI) (2010)	0.5	0.7	3.3	-0.2	-0.2	0.7	1.8	-0.2	0.1
Coronary Artery Disease (CAD)	0.6	0.7	1.6	0.6	-1.2	-0.7	-0.5	0.3	1.2
Crohns Disease (2012)	0.3	0.5	2.0	0.0	-0.6	0.7	0.0	-0.0	-1.4
Mean Putamen Volume	1.9	2.1	4.3	2.1	-1.5	-1.2	1.4	1.7	-0.2
Fasting Glucose	2.1	2.5	4.0	1.7	-1.8	-2.0	-1.0	1.9	-0.4
HbA1C	1.6	1.7	3.3	-1.8	0.5	0.8	-0.5	-1.7	1.7
HDL Cholesterol	0.9	1.6	2.2	-1.3	1.3	1.4	-1.5	-1.2	0.6
LDL Cholesterol	0.2	0.3	1.3	0.1	-0.1	-0.4	-1.1	0.3	0.1
Lupus	0.3	0.4	1.6	0.1	-0.5	0.7	1.3	-0.1	-0.4
Neuroticism (2016)	1.2	1.8	3.8	1.4	-1.1	-2.0	1.5	1.2	0.3
Primary Biliary Cirrhosis	0.7	0.9	2.0	-1.0	1.4	0.7	-0.8	-0.7	-1.0
Rheumatoid Arthritis	0.4	0.6	1.3	1.1	-0.7	0.2	0.2	1.1	-0.7
Schizophrenia (2014)	0.3	0.6	1.7	-0.7	1.3	0.6	0.4	-0.6	0.4
Triglycerides	0.6	1.0	2.3	0.8	-1.4	-1.5	0.5	0.7	0.7
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.3	1.0	-1.1	0.7	-0.2	0.9	-0.4
Ulcerative Colitis	1.0	1.4	2.3	-1.5	1.5	0.8	-0.2	-1.5	0.9
Blood Eosinophil Count	1.4	10.5	15.6	-3.9	3.9	1.6	0.0	-4.0	3.8
Blood Platelet Count	0.0	0.2	0.3	-0.4	-0.3	-0.4	-0.4	-0.5	0.5
Blood Red Count	0.1	0.8	2.2	0.6	-1.5	-0.7	1.2	0.4	-0.5
Blood White Count	0.9	7.0	16.5	-2.9	4.1	1.3	0.6	-2.9	2.6
Heel T-Score	0.2	1.6	7.6	0.3	-0.5	-2.8	0.4	0.3	1.1
BMI	0.4	2.1	4.7	-0.2	0.9	2.2	2.1	-0.3	1.5
Height	0.5	9.8	22.0	-3.3	-0.8	3.6	-4.7	-3.2	1.4
Waist Hip Ratio (WHR)	0.2	0.8	2.1	1.0	-1.4	-0.8	0.4	0.9	0.2
Systolic Blood Pressure	0.4	2.0	5.4	1.1	-2.3	-0.4	1.0	0.9	-1.9
Smoking Status	3.3	8.0	11.9	3.4	-3.2	-2.8	1.1	3.2	-2.4
Allergy or Eczema	0.7	1.8	8.0	-0.8	0.0	2.8	-0.5	-0.9	0.9
Cardiovascular Disease	0.6	2.0	3.9	1.6	-2.0	0.1	0.9	1.4	-1.5
Hypothyroidism (self reported)	2.3	5.4	7.4	-2.5	2.5	2.7	0.1	-2.5	2.5
Respiratory disease	0.8	1.7	8.0	-0.1	0.9	2.8	-0.6	-0.3	-1.1
Type 2 Diabetes (T2D) (2018)	0.9	1.6	4.7	0.2	0.1	1.6	2.2	-0.1	1.5
Lung FEV1/FVC ratio	1.8	9.4	29.8	2.7	-3.3	-5.5	0.2	2.6	-1.2
Lung FVC	5.0	25.3	49.4	5.6	-4.9	-7.0	1.3	5.4	-4.1
Neuroticism	0.2	0.6	2.4	0.4	-0.5	0.7	1.6	0.1	-0.1
Chronotype (morning person)	3.0	6.9	10.7	2.9	-2.8	-3.3	2.6	2.9	0.1
Hair Pigment	0.1	3.6	8.0	-2.4	2.8	1.6	-0.1	-2.2	0.4
Tanning	0.2	2.4	5.9	1.5	-1.8	-2.4	-0.4	1.6	-0.3
Hand grip strength (left)	1.0	2.7	3.9	2.0	-1.9	-1.4	-1.5	2.0	-1.0
Number of treatments/medications taken	0.4	0.7	2.0	0.9	-1.4	0.6	0.3	0.6	0.6
Average weekly spirits intake	0.7	0.8	1.5	-1.0	1.0	0.8	-0.4	-1.2	0.8
Sensitivity / hurt feelings	0.5	0.8	2.8	-0.7	1.7	-0.2	0.4	-0.9	0.7
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.8	-0.0	-0.2	0.5	0.2	-0.4	1.4
Hearing difficulty/problems: Yes	0.5	0.7	2.1	-0.6	0.6	-1.5	-0.2	-0.8	0.9
Relative age of first facial hair	0.5	1.0	1.8	-1.3	0.8	-0.9	-0.2	-1.3	1.0
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.7	-1.3	1.1	0.0	-0.6	-1.3	1.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.0	-0.3	0.7	1.4	0.9	-0.4	0.4
Ever had hysterectomy (womb removed)	0.5	0.6	1.8	0.6	-0.7	0.6	1.3	0.3	0.5
Systolic blood pressure, automated reading	1.2	3.4	8.7	1.5	-1.3	0.8	2.9	1.2	-2.4
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.2	0.5	-1.2	1.5	-0.9	0.5	-1.1
Angina	0.6	0.7	2.0	-0.0	1.4	1.4	0.7	-0.2	-0.0
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.5	-0.2	-0.0	0.3	-0.5	0.8
Vitamin and mineral supplements	0.6	0.8	2.7	0.3	-0.7	0.9	0.6	0.3	-1.6
Supplements: Zinc	2.1	2.3	6.5	-1.6	1.0	-0.4	-2.6	-1.5	1.1
Medication: Co-codamol	0.3	0.4	1.3	-0.6	0.3	0.2	-0.2	-0.8	1.1
Medication: Metformin	0.5	0.7	1.8	0.1	-0.4	1.3	1.3	-0.1	0.7
Diabetes (father)	2.0	2.5	4.0	1.8	-2.0	-0.3	1.9	1.8	0.7
Diabetes (mother)	2.8	3.6	5.6	2.2	-2.1	-2.4	1.4	2.1	-0.0
Severe depression (siblings)	0.8	0.9	2.4	0.2	-1.1	-1.5	-1.3	0.1	0.5
Pack years adult smoking proportion	2.6	4.0	7.5	2.7	-2.1	-1.7	1.5	2.5	-0.6
Impedance of leg (right)	1.5	7.4	14.6	3.0	-3.8	-2.5	0.6	3.2	-2.0
Leg fat-free mass (left)	0.9	4.9	7.3	-2.6	1.6	2.4	-1.6	-2.7	2.1
Trunk fat percentage	0.6	2.5	9.3	1.0	-1.4	1.4	3.0	0.7	0.6
Hand grip strength (right)	0.4	1.0	2.3	0.9	-1.3	-0.6	-1.5	0.9	-0.3
Townsend deprivation index at recruitment	0.4	0.6	1.3	1.1	-0.5	-0.9	-0.1	1.1	-0.3
Current tobacco smoking	1.9	3.1	4.4	2.1	-1.2	-1.5	1.5	2.0	-2.1
Average weekly fortified wine intake	1.3	1.5	3.7	-1.2	1.9	1.5	0.3	-1.2	-0.1
Maternal smoking around birth	1.9	2.8	3.4	1.8	-1.7	-1.9	1.4	1.8	-1.5
Fed-up feelings	0.6	1.0	2.3	0.9	-1.5	-0.5	1.4	0.6	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	4.7	2.2	-1.1	-1.6	1.8	1.9	-0.1
Relative age voice broke	0.6	0.9	1.6	-1.2	1.3	-0.2	0.5	-1.2	-1.0
Taking other prescription medications	1.7	2.7	8.1	1.7	-1.6	0.9	2.8	1.2	-0.6
Age when periods started (menarche)	0.5	1.1	4.5	0.8	0.7	-2.1	-0.6	1.0	-0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	0.9	-0.4	-1.1	0.5	0.8	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	-0.5	0.7	-0.6	0.3	-0.5	0.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.7	-0.1	0.2	1.3	-0.7	-0.3	0.8
Qualifications: CSEs or equivalent	0.3	0.4	1.2	0.6	-1.1	-0.9	0.3	0.4	0.2
Serious illness, injury or assault to yourself	0.8	0.9	2.4	-0.4	1.2	-1.0	-0.3	-0.5	1.6
High blood pressure	0.7	1.9	5.0	1.1	-2.2	0.8	2.0	0.9	0.1
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.2	-0.7	-0.9	1.8	-1.5	-0.5	0.8
Multivitamins +/- minerals	2.5	3.2	5.9	-2.1	2.4	0.2	-0.2	-2.0	2.3
Stomach or abdominal pain in last month	0.1	0.1	0.6	0.0	-0.1	0.0	0.1	0.0	0.8
Supplements: Glucosamine	2.6	3.3	5.5	-2.3	2.3	-0.3	0.3	-2.4	1.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.5	-0.8	-0.0	-0.1	-1.2	-0.8	0.2
Medication: Atenolol	0.1	0.1	0.3	-0.1	-0.2	0.5	-0.3	-0.3	0.2
Medication: Levothyroxine sodium	0.5	0.8	1.5	-0.9	1.1	1.2	0.1	-0.8	0.9
Sitting height	0.2	1.6	2.6	-1.4	-1.1	0.7	-1.6	-1.4	1.1
Chronic bronchitis/emphysema (father)	0.8	0.9	2.6	-0.9	1.6	0.1	-0.6	-1.1	0.8
High blood pressure (mother)	0.1	0.1	0.5	0.2	-0.3	-0.7	-0.1	0.2	-0.0
Body mass index (BMI)	0.5	2.0	5.2	-0.2	1.0	2.1	2.3	-0.5	1.1
Impedance of leg (left)	1.5	7.4	15.3	3.0	-3.9	-2.2	1.2	3.2	-2.0
Leg predicted mass (left)	0.9	5.0	7.5	-2.6	1.6	2.4	-1.6	-2.7	2.1
Trunk fat mass	0.3	1.5	4.1	0.2	-0.9	1.8	2.0	-0.1	1.0
Waist circumference	0.4	1.5	3.2	-0.5	0.3	1.8	1.6	-0.7	1.6
Number of incorrect matches in round	0.4	0.7	1.7	0.1	-0.8	-0.8	-1.1	0.0	-1.3
Past tobacco smoking	1.3	2.4	4.6	-1.9	2.1	1.3	-0.4	-1.9	0.8
Alcohol usually taken with meals	1.6	2.6	12.1	-0.8	0.5	-1.2	-3.5	-0.9	0.4
Nervous feelings	1.0	1.8	3.2	-1.8	1.1	1.8	-0.6	-1.7	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.1	0.8	-0.8	-1.0	1.4	0.5	-0.3
Hearing difficulty/problems with background noise	0.3	0.5	1.9	0.2	-0.6	-1.4	-0.7	0.1	-0.2
Hair/balding pattern: Pattern 2	0.7	0.9	3.3	0.7	-0.8	0.8	1.8	0.6	-0.5
Had menopause	1.1	1.3	3.7	-1.0	1.3	1.9	0.1	-1.1	0.5
Had other major operations	0.9	1.1	3.2	1.2	-0.5	-1.8	-0.3	1.1	-0.5
Forced vital capacity (FVC)	1.6	6.0	11.8	2.4	-3.4	-3.0	-0.4	2.3	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	4.3	-0.9	1.4	-0.2	0.3	-0.9	2.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.1	1.6	-1.4	-0.2	0.0	1.7	-1.8
Qualifications: None of the above	2.1	4.4	9.5	2.5	-1.3	-0.8	3.1	2.3	-1.8
Financial difficulties in last 2 years	2.7	3.6	5.3	1.6	-2.3	-2.1	-1.8	1.9	-1.5
Mouth/teeth dental problems	4.3	6.6	12.3	-3.5	1.9	1.2	-1.2	-3.4	3.1
Heart attack	0.5	0.7	1.8	1.1	-1.3	0.3	0.2	1.0	0.0
Allergy	0.5	1.2	5.1	0.1	0.8	-2.2	1.1	-0.0	-0.3
Pain all over the body in last month	0.3	0.3	1.4	0.2	0.1	-1.2	0.3	0.4	0.4
Diabetes (self-reported)	1.3	2.0	6.0	-0.2	0.3	2.4	1.8	-0.3	1.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.5	0.4	-1.2	1.1	-1.2	0.5	-0.4
Medication: Ramipril	0.6	0.8	3.1	0.3	-1.1	1.8	-0.5	0.2	0.4
Medication: Simvastatin	0.6	0.9	2.1	1.1	-1.4	0.2	0.8	1.0	-0.6
Fluid intelligence score	1.7	3.6	5.9	-2.4	1.6	2.1	1.3	-2.4	1.2
Illnesses of siblings	0.5	0.6	2.1	0.5	-0.6	-1.4	0.7	0.5	0.6
Neuroticism score	0.2	0.5	2.3	-0.1	0.2	0.1	1.5	-0.4	0.6
Weight	0.5	2.4	7.0	-1.3	0.6	2.6	0.3	-1.5	1.7
Impedance of arm (right)	1.1	5.0	11.7	2.1	-3.4	-2.7	0.2	2.2	-1.2
Arm fat percentage (right)	0.4	1.6	7.0	0.8	-0.6	1.0	2.7	0.5	0.6
Trunk fat-free mass	1.4	8.2	11.8	-3.4	2.0	2.5	-3.4	-3.4	2.0
Hip circumference	0.4	1.6	4.5	-1.3	0.5	2.1	0.3	-1.4	1.2
Time employed in main current job	0.7	0.8	1.8	1.3	-1.1	-0.6	0.1	1.2	-0.4
Alcohol intake versus 10 years previously	0.9	1.3	3.1	0.6	-0.9	-1.6	-1.8	0.7	-0.8
Father’s age at death	1.2	1.6	5.7	0.9	-1.5	-0.0	-0.1	1.0	-2.4
Worrier / anxious feelings	0.4	0.7	1.7	0.9	-1.0	-1.3	0.1	0.8	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.4	1.7	-0.8	-1.1	1.8	1.5	0.1
Falls in the last year	0.3	0.4	1.7	0.4	-0.0	-0.1	1.3	0.4	0.4
Hair/balding pattern: Pattern 3	0.5	0.8	2.8	-0.5	0.9	-1.7	0.7	-0.5	0.1
Number of live births	0.8	1.2	2.6	1.5	0.1	-1.1	0.3	1.6	-1.0
Forced expiratory volume in 1-second (FEV1)	2.5	8.6	16.2	2.7	-3.9	-4.0	-0.6	2.7	-2.3
Pulse rate	0.4	0.6	1.9	-0.7	1.4	0.4	-0.9	-0.6	0.2
Happiness	0.4	0.4	2.4	0.3	0.1	1.5	0.4	0.2	0.1
Noisy workplace	4.5	5.6	9.6	2.7	-3.1	-2.5	0.7	2.5	-1.9
Qualifications: A levels/AS levels or equivalent	2.0	4.3	13.6	-2.2	1.8	0.0	-3.7	-2.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.5	-0.7	-0.0	-0.3	0.6	0.2
Mouth/teeth dental problems: Dentures	1.1	1.8	4.8	1.8	-0.2	-0.4	2.2	1.5	-0.6
Asthma	0.6	1.1	5.6	-0.5	0.7	2.4	-0.1	-0.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.8	1.3	-1.7	-0.9	-0.3	1.1	0.7
Medication: Cholesterol lowering	0.8	1.3	4.2	0.9	-2.0	0.8	1.2	0.7	0.0
Depression (self-reported)	0.8	1.0	3.7	0.9	-1.9	-0.3	0.6	0.9	-0.4
Medication: Lansoprazole	0.3	0.3	0.7	0.8	-0.5	0.2	-0.3	0.8	-0.5
Prospective memory result	0.3	0.4	1.7	-0.4	-0.4	0.3	-0.4	-0.5	1.3
Lung cancer (father)	1.4	1.6	6.0	1.0	-1.0	-2.5	-0.6	1.1	0.1
Illnesses of mother	0.2	0.2	0.6	-0.2	-0.7	-0.8	-0.5	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.7	11.7	20.4	3.3	-4.0	-4.5	-1.1	3.2	-3.3
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.5	0.2	0.5	0.1	-0.6	0.6
Impedance of arm (left)	0.7	3.2	8.3	1.6	-2.9	-1.9	1.0	1.6	-1.1
Arm fat mass (right)	0.3	1.1	3.2	0.0	-0.1	1.5	1.8	-0.3	1.0
Trunk predicted mass	1.5	8.5	12.2	-3.5	2.0	2.5	-3.5	-3.5	2.0
Standing height	0.6	5.5	16.9	-2.5	-0.7	1.5	-4.1	-2.4	1.3
Length of working week for main job	0.1	0.1	0.3	0.4	0.1	0.5	0.1	0.4	0.5
Exposure to tobacco smoke at home	0.5	0.5	1.7	-0.5	1.3	-0.8	-0.4	-0.7	-0.3
Breastfed as a baby	0.3	0.3	1.0	0.5	-0.2	1.0	0.7	0.2	0.2
Tense / ‘highly strung’	0.8	1.3	3.1	1.1	-1.8	-0.4	1.0	1.0	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	4.9	2.2	-1.9	-1.1	-0.2	2.1	-1.2
Hair/balding pattern: Pattern 4	0.6	1.4	3.1	-0.6	1.3	1.5	-1.8	-0.6	-0.6
Birth weight of first child	1.2	2.1	4.0	-1.5	2.0	0.7	-1.2	-1.5	1.4
Peak expiratory flow (PEF)	2.2	5.1	10.8	2.3	-2.5	-3.3	-0.7	2.5	-1.4
Pulse wave reflection index	1.9	2.3	5.3	-1.7	1.3	0.9	0.3	-1.8	2.3
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	0.6	-0.0	-0.2	0.7	0.4	-0.1
Loud music exposure frequency	1.4	1.5	4.0	1.3	-2.0	-0.4	0.7	1.2	-1.0
Qualifications: O levels/GCSEs or equivalent	3.7	5.8	21.1	-2.3	1.2	-1.4	-4.6	-2.1	1.0
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	4.9	2.2	-2.0	-0.1	0.8	2.1	-1.9
Blood clot in the leg (DVT)	0.9	1.2	2.4	1.6	-1.0	-0.7	0.8	1.5	-0.4
Medication: Paracetamol	1.4	2.3	4.1	1.9	-1.1	-1.2	-2.0	1.8	-0.4
Headache pain in last month	1.5	2.6	4.9	2.2	-1.2	-2.0	-0.0	2.1	-1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	4.1	-0.6	2.0	-0.1	-0.8	-0.4	-0.1
Glaucoma (self-reported)	2.4	2.8	6.2	2.5	-1.2	-0.3	1.3	2.2	-1.5
Gout (self-reported)	0.4	0.6	2.8	0.4	-1.7	0.3	0.7	0.2	0.2
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	4.4	-1.7	1.9	2.1	-0.5	-1.7	1.9
Medication: Amlodipine	1.3	1.9	3.8	1.9	-0.7	0.2	1.2	1.8	-1.5
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.2	-1.0	0.7	1.5	-0.8	-0.9	0.8
Birth weight	1.7	3.7	12.0	-2.0	3.5	-0.1	-1.3	-1.9	0.7
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.4	0.2	0.2	-1.6	-1.5	0.4	-0.1
High blood pressure (siblings)	0.6	0.8	1.4	-1.0	-0.2	1.0	-1.1	-1.2	0.5
Forced vital capacity (FVC), Best measure	2.0	7.2	11.0	2.7	-3.3	-3.0	-0.9	2.5	-2.9
Body fat percentage	0.8	3.1	11.7	1.4	-1.4	1.3	3.4	1.1	0.3
Leg fat percentage (right)	0.8	3.0	10.6	1.6	-0.8	1.5	3.2	1.4	-0.2
Arm fat-free mass (right)	1.1	5.5	7.8	-2.8	1.7	2.8	-1.7	-2.8	2.0
Exposure to tobacco smoke outside home	1.0	1.3	3.0	-0.5	1.7	-1.1	0.6	-0.5	1.6
Comparative body size at age 10	4.3	11.9	16.4	-3.9	4.0	3.5	1.9	-3.7	3.2
Number of full brothers	0.5	0.6	1.0	-0.9	0.7	-0.3	-1.0	-0.7	1.0
Worry too long after embarrassment	1.6	2.7	5.1	-1.9	2.3	1.0	0.1	-1.9	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.2	0.3	-0.5	-1.0	-0.2	-0.7
Wheeze or whistling in the chest in last year	1.0	1.7	2.5	1.5	-1.3	1.4	0.4	1.6	-1.4
Number of children fathered	1.7	1.9	3.7	-1.0	1.9	1.4	1.4	-1.2	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.6	-0.6	-0.3	1.3	-0.2	-0.5	0.3
Age at first live birth	1.8	3.2	8.1	-2.2	0.7	1.4	-2.8	-1.9	0.7
Pulse wave peak to peak time	0.0	0.0	0.1	0.1	0.0	-0.1	-0.3	0.2	-0.4
Health satisfaction	0.4	0.6	1.1	1.0	-0.5	-0.8	0.3	0.9	-0.7
Shortness of breath walking on level ground	2.1	2.5	4.6	-1.9	1.1	1.2	-0.4	-2.0	2.1
Qualifications: College or University degree	1.0	3.0	5.9	-2.4	1.5	1.1	-1.8	-2.2	1.0
Eye problems/disorders: None of the above	4.5	5.2	8.5	-2.9	2.7	1.5	-0.2	-2.8	2.4
Mouth/teeth dental problems: Loose teeth	4.1	4.9	8.3	2.4	-1.6	-0.3	2.9	2.4	-2.6
Emphysema/chronic bronchitis	0.4	0.5	1.8	0.6	-0.1	0.6	-0.5	0.4	-1.3
Medication for pain relief, constipation, heartburn	1.4	2.4	5.3	-2.1	2.3	1.2	0.5	-1.7	-0.2
Neck or shoulder pain in last month	3.1	4.3	8.8	2.2	-2.0	-3.0	0.2	2.0	-2.0
Medication: Blood pressure	0.3	0.6	2.1	0.6	-1.4	-0.2	0.9	0.4	0.3
Angina (self-reported)	0.6	0.7	2.2	0.0	1.5	1.3	0.7	-0.1	-0.1
Migraine (self-reported)	5.4	6.7	11.1	3.2	-2.7	-3.3	0.7	3.1	-1.2
Medication: Ibuprofen	1.2	1.5	3.9	1.4	-2.0	-1.0	-0.5	1.2	-0.2
Medication: Allopurinol	0.2	0.2	0.8	0.2	-0.5	0.6	0.9	0.0	0.0
Medication: Omeprazole	0.5	0.6	1.4	-0.1	-1.1	-0.5	-1.2	-0.1	0.8
Medication: Seretide 50 evohaler	0.6	0.7	1.2	1.1	-1.0	0.1	-0.7	0.9	-0.7
Mean time to correctly identify matches	1.0	1.8	3.1	-0.3	1.6	1.8	1.7	-0.4	-1.5
Heart disease (mother)	0.1	0.1	0.3	0.4	-0.2	0.6	0.1	0.2	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.1	0.6	-0.7	-0.7	0.3	-0.1
Whole body fat mass	0.3	1.3	3.8	0.4	-0.7	1.7	1.9	0.1	0.9
Leg fat mass (right)	0.5	1.9	5.6	0.7	-0.6	2.0	2.4	0.5	0.5
Arm predicted mass (right)	1.0	5.1	7.5	-2.6	1.8	2.5	-1.6	-2.7	2.0
Pulse rate, automated reading	0.9	2.8	9.1	-1.1	3.0	2.1	1.1	-1.0	-0.3
Alcohol intake frequency.	0.8	1.9	3.7	1.9	-0.7	-0.8	-0.8	1.9	-1.6
Comparative height size at age 10	0.5	2.5	5.4	-1.6	-0.6	1.7	-2.3	-1.6	1.2
Number of full sisters	0.3	0.3	0.6	0.2	-0.7	-0.4	-0.8	0.3	-0.8
Suffer from ‘nerves’	0.7	1.2	2.4	-0.9	1.6	0.9	1.5	-0.8	-0.2
Overall health rating	0.6	1.4	2.8	1.7	-1.2	0.2	1.4	1.5	0.0
Chest pain or discomfort	0.9	1.3	2.9	1.7	-0.9	-0.9	0.7	1.3	-1.0
Had major operations	0.4	0.5	1.6	0.1	-0.4	-0.8	-0.5	-0.1	1.3
Age at last live birth	0.8	1.2	5.8	-0.0	-1.0	0.2	-2.4	0.3	-0.4
Family relationship satisfaction	0.3	0.4	1.7	0.4	-0.4	1.3	0.2	0.4	-0.1
Leg pain on walking	1.0	1.3	2.9	-1.2	1.0	0.5	-0.4	-1.4	1.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.8	0.6	-0.1	-0.9	0.7	0.6	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.1	0.6	-0.7	-0.0	-0.1	0.4	1.0
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.8	-1.3	1.2	0.4	0.6	-1.3	0.7
Medication: Aspirin	1.2	1.6	3.4	1.8	-0.9	0.4	1.3	1.5	-1.1
Supplements: Vitamin C	0.6	0.7	1.4	0.5	-0.7	-1.2	-1.1	0.5	0.9
Knee pain experienced in last month	0.4	0.6	1.5	1.2	-0.5	-0.5	0.5	1.1	-0.5
Hypertension (Self-reported)	0.7	2.0	4.5	1.2	-1.8	1.3	2.1	1.0	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.1	-0.4	0.5	0.4	0.0	0.1
Illnesses of father: Heart disease	1.6	2.2	6.7	1.4	-0.3	1.4	2.6	1.4	-0.7
Illnesses of siblings: Diabetes	0.1	0.2	0.4	0.4	0.3	0.4	-0.0	0.6	-0.5
Smoking status: Previous	0.8	1.1	3.3	1.2	-1.8	-0.8	-0.1	1.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.8	5.8	-1.6	-0.4	0.1	-2.4	-1.4	0.1
Whole body fat-free mass	1.2	6.7	9.8	-3.1	1.8	2.6	-2.6	-3.1	2.0
Leg fat-free mass (right)	1.2	6.3	9.7	-3.0	2.0	2.6	-1.7	-3.1	2.3
Arm fat percentage (left)	0.5	2.1	10.0	0.6	-0.2	1.3	3.2	0.3	0.8
Average weekly red wine intake	0.2	0.3	0.5	0.5	-0.2	0.3	-0.6	0.6	-0.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.3	0.4	-0.4	-0.6	-1.2	0.5	-0.1
Mood swings	0.3	0.5	1.4	1.0	-1.2	-0.4	0.3	0.8	0.2
Loneliness, isolation	0.9	1.3	4.5	-1.0	0.6	-0.4	0.7	-1.2	2.1
Long-standing illness, disability or infirmity	1.5	2.2	4.8	2.2	-1.7	0.2	1.0	1.9	-1.2
Ever had bowel cancer screening	0.2	0.2	0.9	0.2	-0.3	0.3	0.9	0.1	0.1
Diabetes diagnosed by doctor	1.3	2.2	5.0	0.1	0.5	2.2	2.0	-0.2	2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.4	0.5	-0.7	-0.8	1.2	0.4	-0.5
Friendships satisfaction	0.4	0.5	1.2	-0.6	-0.2	0.0	-1.0	-0.8	1.1
Qualifications: nursing, teaching	3.4	5.3	19.7	-2.0	0.9	0.3	-4.4	-1.9	1.8
Commuting to job workplace: Walk	2.1	2.2	4.2	1.1	-1.0	-1.9	1.5	1.2	-2.0
Eye problems/disorders: Cataract	2.5	2.9	5.1	2.0	-1.1	-2.3	0.5	1.9	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.4	0.7	-0.7	-1.1	-1.2	1.0	-1.6
Medication for cholesterol	0.2	0.4	0.6	-0.6	0.2	-0.8	-0.7	-0.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.1	1.5	-1.3	-0.0	0.3	1.4	-1.3
Back pain experienced in last month	1.6	2.4	4.8	1.7	-2.2	0.9	1.9	1.5	-0.4
Mineral and other dietary supplements	1.0	1.3	4.0	1.2	-2.0	-0.1	0.0	1.2	-1.1
Breast cancer (self-reported)	0.7	0.9	2.2	-0.7	1.1	-0.1	-1.0	-0.6	-1.5
Asthma (self-reported)	0.4	0.8	4.4	-0.2	0.3	2.1	-0.1	-0.1	0.2
Osteoporosis (self-reported)	1.0	1.3	2.2	1.0	-1.3	-1.3	-0.4	1.0	-1.5
Osteoarthritis (self-reported)	0.4	0.5	1.0	0.7	-1.0	-0.8	0.2	0.7	-0.6
Medication: Aspirin	0.6	0.8	1.8	1.3	-0.6	0.5	1.2	1.1	-0.3
Medication: Gliclazide	0.8	0.9	3.7	0.6	-0.1	1.9	1.0	0.5	-0.0
Illnesses of father: None of the above (group 1)	1.2	1.5	6.5	0.3	-1.4	-2.5	-0.5	0.3	0.4
Smoking status: Current	1.9	3.0	5.8	2.0	-0.9	-1.8	1.1	1.8	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.1	10.8	16.1	3.8	-3.4	-4.0	0.8	3.6	-3.0
Whole body water mass	1.2	6.9	10.2	-3.1	1.9	2.5	-2.6	-3.2	2.1
Leg predicted mass (right)	1.1	6.0	9.4	-3.0	1.9	2.6	-1.7	-3.1	2.2
Arm fat mass (left)	0.3	1.4	3.6	-0.2	0.2	1.9	1.9	-0.5	1.1
Number of self-reported non-cancer illnesses	2.8	4.9	13.7	2.6	-3.7	-0.0	0.4	2.4	-1.8
Average weekly champagne plus white wine intake	0.5	0.7	2.5	-0.6	0.9	0.5	-1.6	-0.5	-0.1
Miserableness	0.4	0.8	1.5	1.1	-0.6	-0.5	1.2	1.0	-0.5
Guilty feelings	0.8	1.3	3.5	-1.3	0.2	0.5	-0.6	-1.4	1.9
Wears glasses or contact lenses	1.8	2.1	4.1	1.7	-2.0	-1.2	0.1	1.7	-1.2
Ever taken oral contraceptive pill	0.4	0.4	0.6	0.5	-0.8	-0.7	-0.5	0.6	0.6
Hearing aid user	0.7	0.7	2.1	-0.9	-0.3	-0.7	0.2	-1.0	1.4
Mother’s age at death	0.8	1.0	3.2	-0.5	1.8	1.3	-0.2	-0.7	0.1
Financial situation satisfaction	0.3	0.4	1.4	-0.0	-0.5	-1.2	-0.6	-0.1	0.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.7	-0.6	1.3	0.8	-0.5	-0.7	0.7
Commuting to job workplace: Public transport	1.0	1.2	2.2	-1.2	1.5	-0.3	-1.4	-1.2	0.1
Eye problems/disorders: Glaucoma	2.3	2.7	6.0	2.5	-1.5	-0.9	0.9	2.2	-1.3
Medication: Blood pressure	0.5	0.9	1.6	1.0	-0.7	1.3	1.2	0.9	-0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	1.1	-0.9	0.2	0.7	0.9	-0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.2	-0.5	1.8	0.1	0.2	-0.6	0.8
High cholesterol (Self-reported)	0.6	1.0	2.0	1.4	-1.1	-0.3	0.7	1.4	-0.6
Medication: Bendroflumethiazide	0.7	1.1	2.8	0.1	1.7	0.3	1.7	0.0	0.8
Medication: Paracetamol	1.3	2.0	5.1	1.7	-0.7	-1.2	-2.3	1.5	-0.2
Medication: Lisinopril	0.4	0.5	0.9	-0.5	-0.9	-1.0	-0.7	-0.5	-0.7
Medication: Atorvastatin	0.8	1.0	3.7	0.7	-0.5	1.9	0.9	0.7	0.5
Illnesses of father: High blood pressure	0.2	0.3	0.8	-0.4	-0.0	-0.6	-0.9	-0.4	-0.4
Alcohol drinker status: Never	0.5	0.6	1.9	-0.1	0.5	1.4	0.6	-0.1	-0.9
Ever smoked	1.5	2.6	4.5	2.1	-2.1	-1.4	-0.0	2.0	-0.8
Basal metabolic rate	1.0	5.3	7.8	-2.7	1.6	2.6	-1.9	-2.8	2.0
Leg fat percentage (left)	0.9	3.2	12.7	1.4	-0.7	1.7	3.6	1.2	-0.1
Arm fat-free mass (left)	1.1	5.8	8.2	-2.8	1.8	2.5	-2.2	-2.9	2.1
Number of operations (self-reported)	0.2	0.3	0.8	0.7	-0.0	-0.9	-0.0	0.7	0.5
Average weekly beer plus cider intake	0.5	0.7	1.7	0.6	-1.3	-1.2	-0.5	0.6	-0.0
Irritability	0.8	1.4	3.3	0.9	-1.8	-0.5	1.8	0.6	0.7
Risk taking	1.6	2.4	5.2	1.7	-1.2	-2.3	0.5	1.6	-1.4
Ever had prostate specific antigen (PSA) test	3.2	3.7	6.1	2.5	-2.2	-2.0	0.5	2.2	-1.2
Fractured/broken bones in last 5 years	1.5	1.9	2.9	-1.4	1.4	1.0	1.7	-1.4	1.1
Age started oral contraceptive pill	0.4	0.5	1.9	-0.5	0.2	0.6	-1.4	-0.5	-0.4
Diastolic blood pressure, automated reading	0.3	0.9	3.1	-0.6	0.6	1.0	1.8	-0.8	0.3
Ever depressed for a whole week	0.4	0.5	0.7	0.8	-0.8	-0.5	-0.7	0.8	-0.4
Unable to work because of sickness or disability	1.3	1.7	5.0	1.3	-0.8	-2.2	-0.6	1.1	-1.0
Commuting to job workplace: Cycle	0.4	0.5	1.0	-0.9	0.7	0.1	-0.7	-1.0	0.3
Myopia	1.7	2.4	4.1	-2.0	1.8	1.0	-1.3	-2.0	0.9
Vascular/heart problems diagnosed by doctor	0.8	2.3	6.2	-1.5	2.5	-0.7	-1.7	-1.3	0.6
Cholesterol lowering medication	0.3	0.4	0.8	0.5	0.3	0.9	0.9	0.5	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.6	0.7	-1.3	-1.2	-0.3	0.6	0.4
Pain experienced in last month	1.9	3.2	5.3	-2.3	2.3	2.0	0.1	-2.1	0.9
Supplements: Calcium	1.9	2.0	5.9	-1.4	1.1	-0.2	-2.4	-1.3	1.2
Basal cell carcinoma (self-reported)	3.8	4.6	7.3	2.7	-1.5	-0.6	2.3	2.6	-2.3
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.7	1.1	-1.3	0.0	0.0	0.9	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.8	1.7	-0.9	-0.6	0.7	1.6	-0.6
Heart disease (siblings)	0.2	0.2	0.6	0.5	0.4	0.2	-0.1	0.5	-0.8
Alcohol drinker status: Previous	0.2	0.2	0.3	0.4	-0.5	0.3	0.5	0.6	0.5
Pack years of smoking	2.3	3.4	7.1	2.7	-1.8	-1.4	1.5	2.4	-0.4
Impedance of whole body	1.3	6.8	15.0	2.7	-3.9	-2.4	1.1	2.8	-1.8
Leg fat mass (left)	0.5	1.8	5.4	0.5	-0.5	2.1	2.3	0.3	0.6
Arm predicted mass (left)	1.0	5.2	7.3	-2.6	1.9	2.3	-2.2	-2.7	1.8