Hub : Genes

PAPD7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.132	0.053	7.1e-03	0.067	NA	0.024	NA	0.042	3.7e-06	NA	4.0e-03	NA	2.2e-04
2	GTEx	Artery Aorta	0.143	0.056	8.3e-03	-0.005	NA	-0.003	NA	-0.004	9.8e-01	NA	5.2e-01	NA	6.1e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.336	0.097	1.7e-03	0.101	NA	0.061	NA	0.146	3.5e-04	NA	4.9e-03	NA	1.8e-05
4	GTEx	Testis	0.363	0.074	5.9e-07	0.215	NA	0.203	NA	0.222	6.7e-10	NA	2.3e-09	NA	3.4e-10
5	GTEx	Thyroid	0.187	0.053	1.7e-04	0.008	NA	-0.003	NA	0.003	8.0e-02	NA	6.7e-01	NA	1.7e-01
6	TCGA	Thyroid Carcinoma	0.092	0.033	2.3e-08	0.078	0.096	0.090	NA	0.099	4.9e-08	1.4e-09	4.2e-09	NA	7.0e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.9	1.4	5.0	1.3	0.4	1.0	0.3	-2.2	-0.8
Bipolar Disorder or Schizophrenia	2.1	5.0	11.8	3.0	-0.3	1.4	0.7	-3.4	-2.6
Depressed Affect (Nagel 2018)	0.2	0.3	0.9	0.0	-0.1	-0.9	0.9	-0.4	-0.4
Depression (Nagel 2018)	0.2	0.3	0.6	-0.2	-0.6	-0.7	0.6	0.4	-0.2
Intelligence (Savage-Jansen 2018)	0.4	1.1	5.5	0.1	0.4	2.4	-0.8	0.7	0.2
Neuroticism (Nagel 2018)	0.2	0.5	1.2	0.5	-0.1	-0.6	1.1	-0.8	-0.8
Schizophrenia (2018)	1.9	4.0	7.8	2.8	-0.6	1.0	0.7	-2.6	-2.7
Schizophrenia vs Biploar Disorder	0.9	1.2	1.8	0.9	-1.3	1.3	-0.8	-1.2	-0.9
Worry (Nagel 2018)	0.0	0.1	0.2	0.1	0.5	-0.4	0.3	-0.3	-0.0
Alzheimer’s Disease (in mother)	1.7	1.9	3.5	-1.5	-1.8	-0.3	-1.9	0.7	1.5
Alzheimer’s Disease (in father)	1.2	1.3	2.1	-1.2	0.2	0.5	-1.5	1.3	1.4
Alzheimer’s Disease (including proxy)	1.1	1.6	4.5	-1.0	-1.1	0.5	-2.1	0.7	1.4
Crohns Disease (2017)	0.3	0.7	1.9	-0.4	-1.4	0.9	-1.0	0.3	0.8
Irritable Bowel Disease (IBD)	0.6	1.5	3.2	0.5	-1.7	1.8	-1.3	-0.9	0.0
Ulcerative Colitis (UC)	0.8	1.5	2.6	1.1	-1.2	1.6	-0.6	-1.6	-0.8
Major Depression (MDD)	0.5	0.6	2.1	0.3	1.4	0.3	0.8	0.8	-0.2
Reaction Time	0.3	0.6	1.1	0.4	-0.4	1.0	-1.0	-1.0	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.9	-0.2	-0.0	1.4	-0.8	0.7	-0.1
Breast Cancer	0.8	2.0	3.8	-1.6	0.4	-0.1	-1.3	1.9	1.9
Ovarian Cancer	0.1	0.1	0.6	0.1	-0.0	-0.0	0.4	0.7	-0.2
Prostate Cancer	0.1	0.2	1.2	-0.2	-1.1	0.2	-0.0	-0.2	-0.0
Age at First Birth	0.2	0.3	0.7	0.3	-0.4	0.8	0.4	-0.8	-0.4
Bipolar Disorder (2011)	0.2	0.2	0.5	0.3	-0.3	0.7	0.1	-0.6	0.2
Body Mass Index (BMI) (2010)	1.9	2.6	7.7	-1.3	-0.1	-2.8	1.0	2.2	0.6
Coronary Artery Disease (CAD)	0.6	0.7	1.4	-0.8	-0.8	0.7	-0.9	0.2	1.2
Crohns Disease (2012)	0.2	0.3	1.3	0.3	-1.1	0.2	0.4	-0.6	-0.3
Mean Putamen Volume	0.8	0.9	3.0	0.1	-0.1	1.7	-1.3	0.0	0.8
Fasting Glucose	0.5	0.6	1.2	1.0	0.8	1.1	-0.4	-0.5	-0.4
HbA1C	0.2	0.2	0.6	-0.3	-0.6	-0.0	-0.8	-0.1	0.3
HDL Cholesterol	0.6	1.1	2.8	1.0	0.7	0.6	0.5	-1.7	-1.2
LDL Cholesterol	0.8	1.3	3.3	-1.0	-0.3	1.0	-1.8	0.3	1.6
Lupus	1.6	2.5	4.3	-0.9	-0.0	2.1	-1.8	1.7	1.9
Neuroticism (2016)	1.0	1.4	3.6	1.1	-0.2	-0.7	1.9	-0.8	-1.6
Primary Biliary Cirrhosis	1.5	2.2	5.8	-0.5	0.1	2.4	-2.0	0.7	1.6
Rheumatoid Arthritis	0.5	0.7	2.0	-0.6	-0.2	-0.3	-1.4	0.8	1.1
Schizophrenia (2014)	2.6	5.7	10.9	3.3	-0.9	1.6	0.5	-3.2	-3.1
Triglycerides	0.2	0.3	0.9	-0.4	-1.0	0.3	-0.7	0.5	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	-0.4	0.3	0.4	0.5	0.8	0.2
Ulcerative Colitis	0.5	0.7	2.0	0.5	0.3	1.4	-1.0	-0.9	-0.1
Blood Eosinophil Count	1.5	11.2	27.0	-3.1	-0.1	2.3	-5.2	1.5	4.8
Blood Platelet Count	0.4	4.9	9.1	-1.5	3.0	1.5	-2.4	2.0	2.5
Blood Red Count	0.2	2.3	6.2	-1.0	2.5	-1.6	0.4	1.9	0.7
Blood White Count	0.4	2.8	5.0	-2.2	-0.9	-0.5	-2.0	1.3	2.2
Heel T-Score	0.5	3.8	16.4	-0.5	-4.0	0.6	-0.9	-2.1	0.7
BMI	0.4	2.2	4.8	1.0	1.6	-1.5	2.2	-0.2	-1.7
Height	1.6	30.2	71.1	5.5	1.7	-3.1	8.4	-2.3	-7.8
Waist Hip Ratio (WHR)	0.1	0.5	1.1	0.6	-0.2	-1.1	0.5	-0.4	-0.9
Systolic Blood Pressure	0.8	3.8	9.4	0.1	1.7	3.1	-3.0	-0.1	1.2
Smoking Status	0.2	0.6	2.2	-0.7	0.5	0.2	-0.1	1.5	0.5
Allergy or Eczema	0.8	2.2	6.0	-0.4	-1.4	1.7	-2.4	-0.3	1.5
Cardiovascular Disease	0.6	2.0	6.9	0.5	1.3	2.6	-1.7	-0.7	0.5
Hypothyroidism (self reported)	0.3	0.7	2.1	0.5	0.2	-1.5	0.9	-0.5	-0.8
Respiratory disease	0.2	0.5	1.4	-0.2	-0.9	1.2	-0.9	0.1	0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.5	-0.5	-1.2	0.4	-0.2	0.2	0.4
Lung FEV1/FVC ratio	0.4	1.9	2.9	-1.7	-1.6	0.1	-1.5	1.1	1.6
Lung FVC	0.0	0.1	0.2	0.1	0.3	0.4	-0.5	0.0	0.2
Neuroticism	0.1	0.2	0.4	0.6	-0.4	0.5	0.1	-0.5	-0.3
Chronotype (morning person)	1.6	3.6	7.3	-2.3	1.5	-1.6	-0.6	2.7	2.0
Hair Pigment	0.0	0.2	0.7	-0.4	-0.0	-0.1	0.5	0.9	0.5
Tanning	0.2	2.9	7.0	-0.4	0.4	2.6	-2.6	0.7	1.6
Hand grip strength (left)	1.7	4.4	12.1	0.3	0.4	-3.5	3.3	0.5	-1.8
Number of treatments/medications taken	0.3	0.5	1.3	0.8	-1.2	0.8	-0.5	-0.7	-0.1
Average weekly spirits intake	0.1	0.2	0.6	0.4	0.0	0.1	-0.5	-0.8	-0.1
Sensitivity / hurt feelings	1.2	2.1	5.1	1.1	-1.4	2.2	-1.3	-1.6	0.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.5	0.0	-1.2	0.3	-0.6	-0.3	0.1
Hearing difficulty/problems: Yes	1.7	2.6	5.0	1.9	-0.7	-0.4	1.7	-1.9	-2.2
Relative age of first facial hair	2.3	4.8	9.2	2.4	0.4	-0.9	3.0	-1.9	-3.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.5	1.2	0.2	1.9	-1.4	-0.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.3	-1.0	-0.7	-1.5	0.5	-0.1	0.5
Ever had hysterectomy (womb removed)	0.1	0.2	0.6	-0.3	-0.8	-0.1	-0.1	-0.5	0.1
Systolic blood pressure, automated reading	0.3	1.0	2.2	0.7	1.4	1.5	-1.0	-0.4	-0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.9	0.2	-0.4	0.9	-0.5	0.5	0.1
Angina	2.7	3.6	9.0	-0.7	-2.1	1.9	-3.0	-0.3	1.9
Medication for hormone replacement therapy	1.7	1.9	6.2	-1.7	-0.7	-2.5	-0.0	1.1	0.9
Vitamin and mineral supplements	0.4	0.5	1.8	-0.2	0.4	-0.4	1.3	0.8	-0.3
Supplements: Zinc	1.3	1.4	2.9	1.3	0.1	0.5	0.9	-1.7	-1.6
Medication: Co-codamol	0.3	0.3	1.2	0.8	1.1	0.3	0.3	0.0	-0.4
Medication: Metformin	0.2	0.3	1.4	0.0	-0.0	-0.4	1.2	-0.1	-0.7
Diabetes (father)	0.5	0.6	1.3	-1.2	-0.3	-0.6	-0.7	0.7	1.0
Diabetes (mother)	0.3	0.4	1.3	0.2	0.4	1.1	-0.9	0.2	0.4
Severe depression (siblings)	0.4	0.4	1.1	-0.0	-1.0	-0.4	0.5	-0.8	-0.4
Pack years adult smoking proportion	0.9	1.4	2.9	-1.5	1.2	-0.9	-0.4	1.7	0.8
Impedance of leg (right)	0.1	0.6	1.1	0.7	0.6	1.0	0.8	-0.7	-0.6
Leg fat-free mass (left)	1.5	8.1	18.1	2.0	1.0	-3.3	4.3	-0.8	-3.8
Trunk fat percentage	1.7	7.0	14.8	2.5	1.8	-1.9	3.9	-1.4	-3.5
Hand grip strength (right)	1.7	4.6	13.8	0.8	0.4	-2.9	3.7	-0.3	-2.1
Townsend deprivation index at recruitment	0.8	1.1	3.3	1.4	0.4	0.1	1.0	-0.1	-1.8
Current tobacco smoking	0.1	0.2	1.0	-0.3	-0.1	-0.5	0.1	1.0	-0.2
Average weekly fortified wine intake	1.0	1.2	2.0	-1.2	0.4	-0.6	-1.4	1.4	1.2
Maternal smoking around birth	0.7	1.0	2.5	0.4	-1.0	-0.9	1.6	0.3	-1.0
Fed-up feelings	1.7	3.1	6.0	2.1	1.0	0.3	2.2	-1.6	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.6	-0.4	0.3	-1.9	1.6	0.8	-0.6
Relative age voice broke	1.8	2.7	5.9	2.2	0.1	0.1	2.0	-1.2	-2.4
Taking other prescription medications	0.6	0.9	1.8	1.3	-0.3	-0.3	0.8	-1.1	-1.3
Age when periods started (menarche)	1.7	4.2	8.6	1.6	-1.6	-0.9	2.9	-2.2	-2.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	0.2	0.6	-0.7	1.1	-0.7	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.8	-0.2	-1.7	0.5	0.1	-1.2	-0.1
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	5.0	0.1	2.2	-0.7	1.0	1.7	-0.3
Qualifications: CSEs or equivalent	1.2	1.6	3.4	-0.8	1.0	-1.8	1.3	1.7	-0.0
Serious illness, injury or assault to yourself	0.4	0.5	1.5	-0.4	-0.1	0.6	-1.2	0.6	0.7
High blood pressure	0.6	1.6	4.8	0.7	2.2	1.8	-0.5	-0.8	-0.3
Hayfever, allergic rhinitis or eczema	1.4	2.9	9.1	-0.8	-0.9	1.7	-3.0	-0.2	2.0
Multivitamins +/- minerals	0.1	0.2	0.4	0.1	-0.6	-0.3	-0.4	-0.6	-0.0
Stomach or abdominal pain in last month	2.4	3.0	5.2	1.9	-2.3	0.6	1.0	-2.0	-2.0
Supplements: Glucosamine	2.5	3.3	5.4	2.3	-1.5	0.7	1.5	-2.1	-2.2
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	4.0	1.8	0.9	0.8	1.3	-1.7	-2.0
Medication: Atenolol	0.6	0.8	1.6	-0.4	-0.3	1.3	-1.2	-0.2	1.1
Medication: Levothyroxine sodium	0.4	0.6	1.5	1.2	0.3	0.5	0.1	-0.9	-1.1
Sitting height	0.5	3.8	8.6	2.3	0.3	-0.2	2.7	-1.1	-2.9
Chronic bronchitis/emphysema (father)	0.5	0.6	3.1	0.3	-1.8	0.7	-0.1	0.2	-0.2
High blood pressure (mother)	0.3	0.4	0.7	-0.8	-0.3	-0.3	-0.2	0.9	0.8
Body mass index (BMI)	0.9	3.9	7.5	1.8	0.7	-2.1	2.7	-0.9	-2.7
Impedance of leg (left)	0.1	0.5	0.9	0.7	0.5	0.7	0.9	-0.8	-0.8
Leg predicted mass (left)	1.6	8.3	18.5	2.1	1.0	-3.3	4.3	-0.8	-3.8
Trunk fat mass	2.5	10.7	24.3	2.9	1.8	-2.7	4.9	-1.4	-4.4
Waist circumference	1.9	7.0	13.7	2.3	1.1	-2.6	3.7	-1.3	-3.6
Number of incorrect matches in round	1.7	2.8	9.0	1.1	-3.0	0.4	0.1	-2.4	-0.9
Past tobacco smoking	0.5	1.0	4.0	0.0	-2.0	-0.2	-0.3	-1.3	0.1
Alcohol usually taken with meals	0.1	0.2	0.5	0.1	-0.4	0.7	-0.6	0.1	0.2
Nervous feelings	0.2	0.4	0.9	0.7	0.2	0.2	0.7	-0.9	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.6	-1.1	0.7	-0.6	0.1	0.8
Hearing difficulty/problems with background noise	0.7	1.2	2.6	0.5	-1.6	1.1	-1.6	-0.7	0.1
Hair/balding pattern: Pattern 2	1.1	1.4	2.9	-1.7	-0.5	-1.1	-1.0	0.9	1.5
Had menopause	2.8	3.5	6.7	-2.6	0.7	-1.8	-0.9	2.0	2.3
Had other major operations	1.8	2.2	4.2	2.0	0.5	1.0	0.6	-2.0	-1.8
Forced vital capacity (FVC)	0.6	2.2	6.1	0.9	1.2	-1.4	2.5	-0.4	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	5.1	-0.7	-2.3	0.3	-0.4	-0.7	0.3
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.7	-1.2	0.9	-1.4	0.3	1.9	1.0
Qualifications: None of the above	0.0	0.1	0.2	0.3	0.2	-0.1	-0.2	-0.4	-0.0
Financial difficulties in last 2 years	0.5	0.7	2.0	0.3	-1.4	0.9	-0.4	-1.0	-0.2
Mouth/teeth dental problems	0.5	0.8	2.4	-0.3	-0.8	1.6	-1.1	-0.2	0.6
Heart attack	0.2	0.3	0.8	0.3	-0.1	0.9	-0.7	0.1	0.3
Allergy	1.3	3.0	8.1	-0.0	1.3	-2.4	2.9	0.6	-1.3
Pain all over the body in last month	0.9	0.9	3.0	-1.0	0.5	-0.3	-0.5	1.7	1.0
Diabetes (self-reported)	0.2	0.2	1.1	-0.4	-1.1	0.2	0.3	-0.0	0.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	4.6	-0.7	0.4	0.5	-2.1	0.5	1.4
Medication: Ramipril	0.8	1.1	1.8	-1.1	1.3	-0.9	0.3	1.2	0.9
Medication: Simvastatin	0.2	0.4	1.2	0.4	0.8	1.1	-0.5	0.1	0.0
Fluid intelligence score	0.3	0.7	1.9	-0.4	1.4	1.1	-0.7	0.6	0.1
Illnesses of siblings	0.6	0.9	1.7	1.1	0.7	1.0	0.8	-0.5	-1.3
Neuroticism score	0.1	0.2	0.5	0.6	0.2	0.4	0.0	-0.7	-0.4
Weight	2.6	13.0	28.3	3.2	1.3	-3.1	5.3	-1.6	-5.0
Impedance of arm (right)	0.3	1.3	5.6	0.3	0.5	2.4	-1.0	-0.8	0.4
Arm fat percentage (right)	0.9	3.6	7.1	2.0	0.7	-1.2	2.6	-1.5	-2.7
Trunk fat-free mass	1.7	10.0	23.4	2.5	0.7	-3.2	4.8	-1.1	-4.3
Hip circumference	2.0	8.5	18.1	2.6	2.1	-2.2	4.3	-1.0	-3.9
Time employed in main current job	2.8	3.3	7.3	-2.1	1.6	-0.8	-0.9	2.7	2.0
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.5	0.1	0.6	-0.3	0.0	0.1
Father’s age at death	0.2	0.3	0.6	0.5	-0.5	0.1	-0.8	-0.8	-0.4
Worrier / anxious feelings	0.3	0.5	1.7	0.9	0.1	0.4	0.0	-1.3	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.7	-0.2	-1.3	0.4	-0.3	-0.1	0.3
Falls in the last year	1.2	1.7	6.9	0.8	-2.6	0.7	0.1	-1.2	-0.8
Hair/balding pattern: Pattern 3	2.3	3.4	8.8	0.3	-0.7	3.0	-3.0	0.7	1.3
Number of live births	0.7	1.0	2.2	-1.5	-1.1	-0.3	-0.9	-0.2	1.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.1	0.4	0.0	-1.7	2.0	-0.1	-1.3
Pulse rate	0.0	0.0	0.1	-0.1	0.3	0.1	-0.2	-0.1	0.1
Happiness	0.2	0.2	0.5	0.5	-0.7	0.3	-0.5	-0.3	-0.2
Noisy workplace	1.3	1.6	3.8	1.4	0.0	0.4	1.2	-1.9	-1.6
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.2	-1.8	-0.5	0.4	-1.1	0.8	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.9	0.1	-1.0	-0.3	-0.0	0.4	-0.3
Mouth/teeth dental problems: Dentures	0.3	0.5	1.2	0.9	-0.4	-0.0	0.6	-0.4	-1.1
Asthma	0.2	0.4	1.1	0.1	-0.4	1.0	-1.0	-0.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	2.5	1.3	-0.8	0.1	1.5	-0.9	-1.6
Medication: Cholesterol lowering	0.1	0.2	0.4	0.5	0.7	0.2	0.1	-0.1	-0.4
Depression (self-reported)	2.8	3.3	6.8	2.2	1.2	-0.1	2.1	-1.6	-2.6
Medication: Lansoprazole	1.8	2.0	4.9	0.3	-1.5	-1.7	2.2	-0.2	-1.4
Prospective memory result	0.2	0.3	1.2	-0.4	0.4	-1.1	-0.2	0.1	0.4
Lung cancer (father)	0.6	0.7	2.0	0.6	0.0	-0.9	1.4	-0.6	-0.9
Illnesses of mother	0.9	1.1	3.5	0.9	1.9	0.7	0.7	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.2	0.3	-0.8	-1.3	2.0	-0.2	-1.1
Pulse wave Arterial Stiffness index	0.9	1.1	5.3	0.3	-2.3	0.3	-0.4	-0.9	0.0
Impedance of arm (left)	0.2	0.9	3.6	0.4	1.1	1.9	-0.4	-0.6	0.1
Arm fat mass (right)	1.7	7.2	15.3	2.3	1.4	-2.5	3.9	-1.3	-3.6
Trunk predicted mass	1.7	9.8	22.9	2.5	0.6	-3.1	4.8	-1.1	-4.3
Standing height	1.5	15.2	39.4	3.2	1.6	-2.8	6.3	-1.6	-5.3
Length of working week for main job	0.3	0.3	1.1	-0.6	-1.0	0.2	-0.5	0.4	0.4
Exposure to tobacco smoke at home	0.3	0.3	0.6	-0.2	0.4	-0.8	0.8	0.6	0.2
Breastfed as a baby	1.0	1.2	3.1	-1.8	0.8	-0.8	-0.2	1.2	1.2
Tense / ‘highly strung’	0.1	0.2	0.6	0.2	-0.2	0.7	0.3	-0.8	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	5.6	0.7	-0.4	-1.7	2.4	-0.5	-1.5
Hair/balding pattern: Pattern 4	1.2	2.9	4.9	1.7	0.1	0.3	2.1	-2.2	-2.2
Birth weight of first child	1.6	2.9	6.1	0.3	2.5	-2.3	2.1	-0.2	-1.3
Peak expiratory flow (PEF)	0.3	0.8	1.8	0.3	0.9	-0.6	1.4	0.7	-1.0
Pulse wave reflection index	1.2	1.5	5.2	0.8	-2.3	0.2	-0.1	-1.6	-0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	0.7	-1.0	0.8	-0.4	-1.0	-0.4
Loud music exposure frequency	0.2	0.3	0.6	0.8	-0.2	0.7	0.2	-0.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	2.3	-1.1	0.1	0.8	-0.8	1.5	1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.3	-0.3	1.1	-1.5	1.0	0.7	-0.2
Blood clot in the leg (DVT)	0.8	1.0	5.5	0.4	-2.4	0.5	-0.0	-0.2	-0.2
Medication: Paracetamol	1.6	2.6	9.8	1.0	-3.1	1.4	-0.8	-1.4	-0.5
Headache pain in last month	2.3	4.0	7.8	2.8	-1.5	2.3	0.1	-2.2	-2.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.9	0.1	-0.9	-0.2	0.4	-0.2	-0.4
Glaucoma (self-reported)	0.1	0.1	0.2	0.5	-0.1	0.2	-0.2	-0.4	-0.2
Gout (self-reported)	1.1	1.5	6.2	0.8	-2.5	1.0	0.1	-0.9	-0.7
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.6	1.3	-0.4	0.3	0.2	-1.6	-1.2
Medication: Amlodipine	0.4	0.5	1.7	0.2	-0.2	-0.0	-1.1	-1.3	0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	0.4	0.4	0.2	1.2	0.6	-0.9
Birth weight	1.5	3.2	8.4	0.5	1.6	-2.4	2.9	-0.2	-1.6
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.6	-0.4	-1.3	-1.6	1.0	0.8	-0.1
High blood pressure (siblings)	0.1	0.1	0.1	-0.0	0.3	-0.3	-0.3	-0.1	0.4
Forced vital capacity (FVC), Best measure	0.4	1.4	5.1	0.4	0.8	-1.0	2.3	-0.2	-1.3
Body fat percentage	1.6	6.1	12.3	2.4	1.7	-1.8	3.5	-1.3	-3.3
Leg fat percentage (right)	1.8	6.4	12.7	2.5	1.2	-1.9	3.6	-1.4	-3.5
Arm fat-free mass (right)	1.9	9.9	23.0	2.4	0.9	-3.4	4.8	-0.8	-4.2
Exposure to tobacco smoke outside home	0.3	0.4	1.0	1.0	-0.3	-0.2	0.5	-0.4	-0.9
Comparative body size at age 10	1.2	3.3	5.8	-2.2	-0.1	-2.3	-0.9	2.4	1.7
Number of full brothers	0.7	0.8	1.5	0.2	-0.9	-1.2	1.0	-1.1	-0.6
Worry too long after embarrassment	0.3	0.5	1.1	1.1	0.3	0.7	0.2	-0.9	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.5	1.0	0.6	-0.3	-0.5	0.8	-0.6	-1.0
Wheeze or whistling in the chest in last year	0.7	1.3	5.1	1.0	-2.2	0.4	-0.1	-0.9	-0.9
Number of children fathered	0.7	0.8	2.3	-1.1	-0.0	-0.6	0.6	1.5	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.9	2.0	-0.7	0.8	1.2	-1.3	-1.9
Age at first live birth	0.9	1.5	2.9	-1.7	-0.2	0.2	-1.5	1.1	1.7
Pulse wave peak to peak time	1.1	1.3	6.0	-0.3	2.4	-0.6	0.8	0.9	-0.2
Health satisfaction	0.5	0.6	1.7	-0.1	1.3	0.4	-0.7	1.1	0.4
Shortness of breath walking on level ground	3.3	3.9	8.4	-2.5	0.6	-0.1	-1.4	2.9	2.6
Qualifications: College or University degree	0.2	0.6	2.6	-0.1	-1.6	0.4	-0.4	-0.6	-0.1
Eye problems/disorders: None of the above	1.0	1.2	2.9	0.7	-1.6	-0.1	0.8	-1.7	-0.7
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.7	0.9	0.9	-1.4	1.6	-0.3	-1.6
Emphysema/chronic bronchitis	0.1	0.2	0.4	-0.4	-0.1	0.3	-0.5	0.1	0.6
Medication for pain relief, constipation, heartburn	1.9	3.2	7.6	-1.7	2.8	-1.9	0.6	2.1	0.8
Neck or shoulder pain in last month	0.6	0.8	2.7	1.0	0.8	1.6	-0.7	-0.1	-0.1
Medication: Blood pressure	0.6	1.0	1.8	-1.0	1.3	-0.5	-0.7	1.0	1.3
Angina (self-reported)	2.8	3.6	9.1	-0.7	-2.1	1.9	-3.0	-0.3	2.0
Migraine (self-reported)	0.7	0.9	2.1	1.1	-0.7	1.5	-0.5	-1.0	-0.7
Medication: Ibuprofen	0.9	1.1	1.8	1.0	-1.1	0.1	1.4	-1.0	-1.3
Medication: Allopurinol	1.1	1.5	6.4	-0.0	-2.5	0.9	-0.8	-1.0	0.1
Medication: Omeprazole	1.5	1.8	3.4	1.6	-1.3	1.5	-0.6	-1.8	-0.8
Medication: Seretide 50 evohaler	0.6	0.6	2.8	0.4	-1.7	0.5	0.3	-0.7	-0.3
Mean time to correctly identify matches	0.8	1.6	4.0	0.8	-0.1	2.0	-1.4	-1.6	0.3
Heart disease (mother)	1.3	1.6	3.4	-1.9	-0.0	-0.6	-1.0	1.5	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.4	0.1	0.3	-0.6	1.2	0.4	-0.6
Whole body fat mass	2.4	10.2	22.7	2.7	1.8	-2.9	4.8	-1.4	-4.2
Leg fat mass (right)	2.3	9.1	20.2	2.4	1.7	-2.9	4.5	-1.2	-4.0
Arm predicted mass (right)	2.1	10.5	25.5	2.5	1.0	-3.4	5.0	-0.9	-4.2
Pulse rate, automated reading	0.2	0.8	2.9	1.0	1.7	0.8	-0.0	0.1	-0.6
Alcohol intake frequency.	0.1	0.3	0.6	-0.6	0.3	-0.5	0.0	0.8	0.5
Comparative height size at age 10	1.5	8.5	22.6	2.5	1.9	-1.9	4.8	-0.7	-3.8
Number of full sisters	1.0	1.2	4.8	0.3	-2.2	0.8	-0.9	-1.1	0.0
Suffer from ‘nerves’	0.2	0.3	1.1	-0.3	1.1	-0.0	-0.3	0.7	0.5
Overall health rating	0.5	1.0	2.1	1.5	0.7	0.4	0.7	-1.0	-1.3
Chest pain or discomfort	0.5	0.8	1.9	0.9	-1.4	1.2	-0.2	-0.4	-0.5
Had major operations	0.1	0.1	0.2	-0.1	0.5	0.1	0.1	-0.2	0.4
Age at last live birth	0.5	0.8	1.9	-0.9	-0.1	0.8	-1.4	0.1	1.1
Family relationship satisfaction	0.7	0.9	1.9	0.6	-1.2	1.4	-1.1	-0.4	0.0
Leg pain on walking	0.3	0.4	0.7	0.2	0.9	-0.7	0.8	0.3	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	-0.5	-0.8	-1.3	1.4	0.5	-0.1
Commuting to job workplace: Car/motor vehicle	1.1	1.3	4.2	-0.7	-0.7	-2.1	1.6	-0.1	-0.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.5	5.5	1.1	2.4	0.4	1.1	-0.6	-0.9
Medication: Aspirin	1.0	1.4	3.2	-0.2	-0.9	1.8	-1.7	-0.3	1.1
Supplements: Vitamin C	0.4	0.4	1.2	0.0	-0.5	0.2	-1.1	-1.1	0.2
Knee pain experienced in last month	0.4	0.6	1.2	1.0	0.7	-0.5	0.7	-0.2	-1.1
Hypertension (Self-reported)	0.6	1.5	4.1	0.4	2.0	1.9	-1.0	-0.6	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.8	0.8	0.2	1.3	-0.1	-0.2	-0.4
Illnesses of father: Heart disease	0.5	0.7	1.4	-0.8	0.1	0.5	-1.1	0.8	1.2
Illnesses of siblings: Diabetes	0.7	0.9	1.8	-1.0	0.3	0.1	-1.3	0.8	1.3
Smoking status: Previous	0.8	1.2	6.4	0.4	2.5	-0.0	0.5	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	7.0	0.2	0.3	-2.3	2.6	0.0	-1.4
Whole body fat-free mass	1.7	9.5	22.2	2.2	0.8	-3.4	4.7	-0.9	-4.1
Leg fat-free mass (right)	1.4	7.3	15.9	1.9	0.8	-3.3	4.0	-0.6	-3.6
Arm fat percentage (left)	1.1	4.4	8.3	2.1	1.1	-1.5	2.9	-1.5	-2.9
Average weekly red wine intake	0.7	1.0	1.9	1.4	-0.4	-0.1	0.5	-1.3	-1.3
Handedness (chirality/laterality): Left-handed	0.6	0.7	3.6	0.3	1.9	-0.1	0.3	0.3	-0.6
Mood swings	0.1	0.2	0.5	-0.5	0.0	0.2	-0.4	0.1	0.7
Loneliness, isolation	0.7	0.9	2.3	0.6	-0.1	-1.5	1.2	0.2	-1.2
Long-standing illness, disability or infirmity	0.5	0.7	1.5	-0.3	-0.8	0.8	-1.2	0.9	0.9
Ever had bowel cancer screening	1.5	1.7	3.6	1.6	-1.0	0.6	0.7	-1.9	-1.5
Diabetes diagnosed by doctor	0.2	0.4	2.0	-0.5	-1.4	-0.0	-0.1	0.2	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.5	-0.1	-0.4	0.7	-0.3	-0.6
Friendships satisfaction	0.4	0.5	1.0	0.7	-0.9	0.9	-1.0	-0.4	-0.2
Qualifications: nursing, teaching	0.3	0.5	0.8	-0.7	-0.8	-0.8	0.6	0.9	-0.1
Commuting to job workplace: Walk	2.3	2.5	4.5	-2.1	-0.7	-0.1	-1.4	2.0	2.0
Eye problems/disorders: Cataract	0.9	1.0	1.7	-0.5	1.2	1.3	-1.1	1.1	0.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.0	0.4	0.2	-0.4	-0.6	0.4
Medication for cholesterol	0.2	0.3	0.7	0.8	-0.1	0.1	0.7	-0.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.1	-0.4	-1.0	-0.8	0.6	-0.4	-0.1
Back pain experienced in last month	1.8	2.6	5.9	2.4	0.3	0.6	1.4	-1.2	-2.4
Mineral and other dietary supplements	0.4	0.6	0.8	-0.5	-0.6	0.6	-0.9	0.8	0.9
Breast cancer (self-reported)	0.5	0.7	2.3	0.9	-0.2	0.2	0.5	-1.5	-0.6
Asthma (self-reported)	0.1	0.3	0.8	-0.2	-0.1	0.8	-0.9	-0.2	0.4
Osteoporosis (self-reported)	0.9	1.1	2.6	0.2	1.3	1.6	-1.0	-0.7	0.6
Osteoarthritis (self-reported)	1.2	1.5	3.6	1.9	-0.0	1.1	0.3	-1.6	-1.3
Medication: Aspirin	0.9	1.1	2.5	-0.4	-0.3	1.6	-1.6	-0.2	1.2
Medication: Gliclazide	0.2	0.2	0.4	-0.7	-0.4	-0.2	-0.1	0.5	0.5
Illnesses of father: None of the above (group 1)	3.1	3.8	7.1	2.4	1.3	-0.3	2.5	-1.5	-2.7
Smoking status: Current	0.2	0.3	1.2	-0.3	-0.5	0.0	-0.2	1.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	-0.4	-0.8	0.1	-0.9	-0.4	0.6
Whole body water mass	1.6	9.2	21.3	2.2	0.8	-3.4	4.6	-0.8	-4.0
Leg predicted mass (right)	1.4	7.3	16.1	1.8	0.8	-3.4	4.0	-0.5	-3.5
Arm fat mass (left)	2.0	8.1	17.2	2.4	1.5	-2.7	4.2	-1.3	-3.8
Number of self-reported non-cancer illnesses	2.0	3.5	6.9	2.6	0.3	1.7	0.3	-2.6	-2.1
Average weekly champagne plus white wine intake	1.6	2.2	4.5	-1.4	-0.6	1.1	-2.1	0.9	2.0
Miserableness	0.4	0.7	1.7	-1.1	0.1	-1.3	1.0	0.4	0.4
Guilty feelings	0.2	0.3	0.8	0.6	-0.4	-0.2	0.1	-0.9	-0.6
Wears glasses or contact lenses	1.1	1.3	4.0	-1.4	-0.1	0.5	-1.0	0.8	2.0
Ever taken oral contraceptive pill	1.6	1.8	5.3	-0.7	-0.3	-2.3	1.6	1.2	-0.6
Hearing aid user	0.8	0.9	2.4	1.5	0.5	1.4	0.1	-0.2	-0.9
Mother’s age at death	0.9	1.2	2.3	1.1	-0.5	-0.4	1.0	-1.5	-1.4
Financial situation satisfaction	1.7	2.1	4.3	-1.5	-2.1	-0.0	-1.6	0.8	1.7
Tinnitus: Yes, now most or all of the time	1.3	1.6	3.3	1.8	0.6	0.8	1.0	-1.3	-1.6
Commuting to job workplace: Public transport	1.0	1.1	2.7	0.1	0.9	1.6	-1.6	0.7	0.5
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	0.7	-0.9	0.6	-0.3	-0.6	-0.4
Medication: Blood pressure	0.8	1.6	3.7	1.2	1.1	1.9	-0.4	-1.6	-0.6
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.3	1.6	0.4	-0.0	1.6	-1.3	-2.1
Supplements: Fish oil (including cod liver oil)	1.0	1.4	4.2	-0.8	2.0	-1.8	0.4	0.4	0.2
High cholesterol (Self-reported)	0.3	0.6	1.5	-0.6	1.0	0.5	-0.0	1.2	0.5
Medication: Bendroflumethiazide	1.0	1.5	7.2	0.5	2.7	1.1	-0.6	-0.1	0.2
Medication: Paracetamol	1.3	2.0	5.1	1.4	-2.3	1.5	-0.5	-1.5	-0.7
Medication: Lisinopril	0.2	0.3	0.7	0.4	0.3	-0.8	0.8	-0.1	-0.5
Medication: Atorvastatin	1.0	1.2	3.1	-0.4	0.4	-1.8	1.5	1.3	-0.2
Illnesses of father: High blood pressure	0.4	0.5	1.6	-0.1	1.3	-1.0	0.2	0.0	-0.3
Alcohol drinker status: Never	0.3	0.4	1.5	-0.7	-1.2	-0.3	-0.1	-0.1	0.5
Ever smoked	0.9	1.5	5.2	-0.5	2.3	0.2	-0.1	1.9	0.4
Basal metabolic rate	2.0	11.0	25.3	2.5	1.0	-3.5	5.0	-1.0	-4.4
Leg fat percentage (left)	1.8	6.5	12.5	2.5	1.2	-2.0	3.5	-1.4	-3.5
Arm fat-free mass (left)	2.1	10.6	25.7	2.4	0.7	-3.5	5.1	-1.0	-4.3
Number of operations (self-reported)	0.3	0.4	1.3	0.6	0.2	0.7	-0.3	-1.1	-0.3
Average weekly beer plus cider intake	0.5	0.8	2.2	1.1	-0.3	0.4	0.0	-1.5	-1.1
Irritability	0.2	0.3	0.7	0.5	-0.4	0.0	0.2	-0.8	-0.7
Risk taking	0.7	1.1	2.9	-1.4	-0.1	-0.3	-1.2	0.4	1.7
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.3	0.1	-0.5	1.2	-1.5	-0.7	0.5
Fractured/broken bones in last 5 years	1.1	1.4	3.0	-1.7	-0.3	-1.4	-0.4	1.4	1.2
Age started oral contraceptive pill	0.1	0.1	0.6	-0.1	0.8	0.2	-0.1	-0.2	0.1
Diastolic blood pressure, automated reading	0.7	2.3	4.4	1.8	2.0	0.2	1.3	-0.6	-2.1
Ever depressed for a whole week	0.7	0.9	2.4	-1.0	0.2	-1.5	0.5	1.1	0.5
Unable to work because of sickness or disability	0.9	1.2	2.4	-1.2	-1.5	-0.7	-1.1	0.6	1.2
Commuting to job workplace: Cycle	1.0	1.2	3.0	1.5	0.7	0.6	0.6	-0.8	-1.7
Myopia	0.3	0.5	2.4	0.1	1.5	0.6	0.3	0.1	-0.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	6.4	-1.3	-1.5	-2.5	0.9	1.5	0.4
Cholesterol lowering medication	0.1	0.1	0.3	0.1	0.2	0.5	-0.1	-0.3	0.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	2.1	1.4	-1.4	1.4	-0.4	-1.5	-0.7
Pain experienced in last month	0.8	1.3	3.5	-1.9	-0.4	-1.3	-0.6	0.5	1.3
Supplements: Calcium	0.4	0.4	1.7	0.6	-0.2	1.3	-0.1	-0.5	-0.4
Basal cell carcinoma (self-reported)	2.3	2.7	5.1	-1.7	-0.5	0.5	-2.0	2.0	2.2
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.1	0.5	-0.2	1.1	-0.7	-0.3	0.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	4.9	0.0	-2.2	0.6	-0.3	0.2	0.2
Heart disease (siblings)	1.2	1.4	2.9	-1.4	-1.7	-1.4	-0.6	0.0	1.2
Alcohol drinker status: Previous	1.3	1.5	4.1	1.0	2.0	0.3	1.3	-0.1	-1.4
Pack years of smoking	1.0	1.4	3.0	-1.3	1.7	-0.7	-0.6	1.5	0.8
Impedance of whole body	0.1	0.7	2.9	0.3	0.8	1.7	-0.1	-0.6	0.1
Leg fat mass (left)	2.4	9.3	20.2	2.5	1.7	-3.0	4.5	-1.2	-4.0
Arm predicted mass (left)	1.9	9.9	23.1	2.5	0.7	-3.3	4.8	-0.8	-4.2