Hub : Genes

PAQR8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1690	0.0380	1.0e-08	0.056	0.097	0.150	0.135	0.141	2.2e-07	7.4e-12	7.3e-18	4.4e-16	9.1e-17
2	GTEx	Adipose Subcutaneous	0.0880	0.0340	2.5e-03	0.006	NA	0.054	NA	0.028	9.8e-02	NA	2.9e-05	NA	2.1e-03
3	GTEx	Artery Aorta	0.2140	0.0590	1.0e-04	0.021	NA	0.043	NA	0.042	2.5e-02	NA	2.0e-03	NA	2.2e-03
4	GTEx	Artery Tibial	0.1130	0.0342	1.9e-04	0.118	NA	0.131	NA	0.120	1.6e-09	NA	2.0e-10	NA	1.2e-09
5	GTEx	Cells Transformed fibroblasts	0.2690	0.0580	2.8e-07	0.134	NA	0.211	NA	0.203	3.2e-10	NA	9.4e-16	NA	3.4e-15
6	GTEx	Skin Sun Exposed Lower leg	0.1370	0.0400	1.0e-04	0.033	NA	0.047	NA	0.061	9.6e-04	NA	9.1e-05	NA	8.3e-06
7	METSIM	Adipose	0.1576	0.0384	1.6e-07	0.024	0.064	0.088	0.065	0.067	1.5e-04	6.8e-10	4.0e-13	4.7e-10	3.3e-10
8	NTR	Blood	0.0851	0.0183	1.6e-12	0.063	0.044	0.058	0.059	0.062	2.0e-19	6.2e-14	3.5e-18	3.0e-18	3.9e-19
9	ROSMAP	Brain Pre-frontal Cortex	0.1811	0.0360	7.6e-12	0.099	0.094	0.122	0.123	0.131	1.2e-12	4.1e-12	2.3e-15	1.8e-15	1.7e-16
10	TCGA	Breast Invasive Carcinoma	0.0534	0.0188	5.2e-06	0.029	0.028	0.031	NA	0.026	1.0e-06	1.7e-06	5.1e-07	NA	3.5e-06
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0747	0.0254	2.2e-06	0.059	0.062	0.059	NA	0.058	3.5e-07	1.6e-07	3.3e-07	NA	3.7e-07
12	TCGA	Prostate Adenocarcinoma	0.0396	0.0184	5.2e-03	0.025	0.014	0.027	NA	0.027	9.8e-04	1.3e-02	6.9e-04	NA	7.2e-04
13	TCGA	Thyroid Carcinoma	0.0840	0.0300	8.7e-06	0.041	0.058	0.030	NA	0.049	6.5e-05	2.6e-06	6.3e-04	NA	1.4e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.3	0.4	1.0	-0.8	0.4	-0.4	-0.3	-0.5	-0.9	-0.2	0.7	-0.2	-1.0	-0.8	-1.0	0.2
Bipolar Disorder or Schizophrenia	0.4	0.9	3.6	-1.3	0.3	-0.7	-0.4	-1.9	-0.7	-0.3	1.4	-0.5	-1.2	-0.6	-0.9	0.0
Depressed Affect (Nagel 2018)	0.7	1.4	3.2	1.3	0.6	1.5	1.2	1.8	1.1	-0.9	0.9	1.1	1.4	1.2	1.1	-0.3
Depression (Nagel 2018)	0.3	0.4	2.0	0.8	0.6	0.2	0.0	0.8	0.1	-1.4	-1.2	0.6	0.4	-0.4	0.2	0.4
Intelligence (Savage-Jansen 2018)	2.3	7.0	18.3	1.4	1.8	1.9	3.9	0.9	4.0	2.4	-1.3	1.8	2.9	2.7	2.3	4.3
Neuroticism (Nagel 2018)	0.2	0.5	4.0	0.5	0.3	0.1	0.0	1.0	-0.1	-2.0	0.2	0.5	0.1	-0.1	-0.2	-0.8
Schizophrenia (2018)	0.3	0.6	3.8	-1.0	0.0	-0.5	-0.2	-1.9	-0.1	-0.2	1.2	-0.5	-0.8	-0.2	-0.3	-0.2
Schizophrenia vs Biploar Disorder	0.5	0.6	3.3	-0.4	0.8	0.4	0.6	-0.1	0.8	0.5	1.8	-0.1	0.8	0.9	0.8	0.4
Worry (Nagel 2018)	0.2	0.4	2.0	-0.5	1.4	0.8	0.4	1.0	-0.1	-0.7	0.2	-0.7	0.2	0.3	0.1	-0.1
Alzheimer’s Disease (in mother)	0.9	1.1	2.9	-0.5	-1.0	-0.1	-1.3	0.7	-1.7	-1.0	0.5	-1.5	-1.3	-0.5	-1.5	-0.7
Alzheimer’s Disease (in father)	0.8	0.8	4.3	-1.2	0.0	0.0	0.8	-1.1	0.8	0.3	-2.1	-0.7	-0.2	-0.2	0.8	1.1
Alzheimer’s Disease (including proxy)	0.4	0.5	2.1	-1.2	-0.5	0.1	-0.2	0.4	-0.8	-0.1	-1.0	-1.4	-0.9	-0.5	-0.5	0.1
Crohns Disease (2017)	1.0	2.2	5.2	2.0	-1.2	1.5	1.2	0.0	1.6	0.7	-1.1	1.5	1.2	2.1	2.3	1.6
Irritable Bowel Disease (IBD)	0.5	1.2	2.2	0.6	-0.2	1.4	1.4	0.5	1.0	1.3	-1.1	0.5	1.3	1.3	1.5	1.2
Ulcerative Colitis (UC)	0.1	0.2	0.9	-0.5	0.4	0.5	0.7	0.3	-0.0	1.0	-0.1	0.1	0.5	-0.1	0.2	0.0
Major Depression (MDD)	1.3	1.6	7.2	-1.5	1.1	-0.3	1.7	-1.2	1.8	-0.3	-2.7	-0.1	-0.0	0.0	1.3	0.5
Reaction Time	0.3	0.6	1.7	-1.3	-1.0	0.6	0.6	0.6	-0.0	-1.0	0.3	-1.0	0.6	0.8	0.1	0.5
Verbal and Numeric Reasoning (VNR)	2.6	6.3	13.6	-0.1	2.4	1.8	3.7	0.9	3.6	3.0	0.2	0.3	2.8	3.0	2.8	3.5
Breast Cancer	0.4	1.0	5.2	2.3	-0.7	0.7	-0.7	0.7	-0.1	0.1	1.1	1.9	0.2	0.3	0.2	-0.8
Ovarian Cancer	0.6	0.8	6.0	-0.3	2.4	-0.8	0.8	-0.5	0.3	1.3	0.1	0.2	-0.1	0.4	0.4	-0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	4.3	6.2	15.0	-0.7	-1.1	-3.1	-3.5	-0.8	-3.9	-0.9	0.2	-0.3	-3.6	-3.6	-3.1	-2.4
Bipolar Disorder (2011)	1.9	1.9	7.7	-2.8	-0.7	-1.3	-0.2	0.6	-1.0	-0.9	0.6	-2.7	-0.6	-0.6	-1.8	0.8
Body Mass Index (BMI) (2010)	0.6	0.8	3.2	-0.9	0.9	1.8	0.4	0.7	0.2	0.2	1.0	-1.2	0.4	1.2	1.0	0.3
Coronary Artery Disease (CAD)	0.8	0.9	2.2	1.0	-0.7	1.1	0.9	0.3	1.2	1.2	0.5	1.3	0.7	0.6	1.5	-0.7
Crohns Disease (2012)	3.1	5.0	10.9	0.7	1.2	2.4	2.7	1.8	2.5	2.3	0.4	0.5	2.5	3.3	2.8	3.1
Mean Putamen Volume	0.2	0.3	1.3	-0.3	-0.6	-0.9	-0.4	-0.5	-0.0	-0.3	-1.1	-0.5	-0.1	0.3	0.4	-0.4
Fasting Glucose	0.6	0.7	3.0	-0.1	1.7	0.6	0.5	-0.9	1.1	1.2	0.1	0.0	-0.2	-0.3	1.4	-0.3
HbA1C	0.4	0.4	2.0	-0.8	0.1	-0.5	-0.4	0.2	-0.7	0.2	0.9	-1.4	0.2	-0.1	-0.6	0.5
HDL Cholesterol	0.6	1.0	7.6	-0.5	2.8	-0.2	0.9	-0.4	1.0	-0.9	-0.3	-0.0	0.4	0.6	0.8	1.3
LDL Cholesterol	1.1	1.7	5.7	-1.8	-1.4	2.4	0.2	1.8	-1.1	1.2	0.0	-2.0	-0.6	0.7	0.7	-0.4
Lupus	0.5	0.7	2.6	0.2	-1.3	1.6	-0.8	-0.4	-0.3	-0.2	0.4	0.4	-0.5	0.5	1.5	-1.1
Neuroticism (2016)	1.3	1.9	4.9	-0.6	-1.1	-1.3	-1.5	-1.0	-1.6	-2.2	0.4	-0.9	-0.8	-1.2	-1.8	-2.1
Primary Biliary Cirrhosis	0.3	0.4	2.3	-0.7	-0.4	1.5	0.4	0.1	0.8	0.3	0.3	-0.2	0.7	0.4	0.8	0.0
Rheumatoid Arthritis	0.7	1.0	2.8	1.2	-0.7	1.1	-0.6	-0.3	-0.3	1.2	-1.6	1.0	-0.7	-0.7	0.5	-1.7
Schizophrenia (2014)	0.9	2.0	5.3	-0.5	0.4	-2.2	-1.2	-2.3	-1.4	-0.6	2.0	0.0	-1.3	-1.1	-2.0	-1.0
Triglycerides	1.0	1.7	6.2	0.1	-1.4	2.0	0.9	2.5	0.5	2.1	-1.1	-0.6	0.9	0.8	-0.0	1.1
Type 2 Diabetes (T2D) (2012)	2.4	2.8	7.2	-2.1	2.3	1.5	2.0	1.3	0.8	1.8	1.4	-2.7	1.4	1.8	0.5	0.2
Ulcerative Colitis	0.3	0.5	2.1	-1.4	1.4	0.8	0.3	0.6	-0.4	0.2	0.2	-1.0	-0.3	-0.4	-0.1	0.1
Blood Eosinophil Count	0.5	3.8	16.7	-1.4	0.5	4.1	0.8	-1.1	1.3	2.4	0.9	-1.8	0.8	1.9	3.4	1.4
Blood Platelet Count	2.7	30.9	110.2	4.2	-6.6	10.5	4.0	7.2	3.9	4.2	-2.0	1.5	4.1	7.0	6.9	3.1
Blood Red Count	0.5	5.2	24.0	-3.6	0.8	-1.9	-2.3	-0.5	-2.9	-1.5	-0.6	-4.9	-1.7	-1.1	-2.3	-0.4
Blood White Count	1.4	10.4	28.7	-0.6	3.2	2.7	3.2	-0.9	3.9	4.5	1.3	-0.6	3.3	4.6	5.4	2.8
Heel T-Score	0.3	2.1	6.2	-0.7	1.1	2.2	1.0	-1.1	1.8	0.8	-1.3	-0.9	0.4	1.4	1.8	2.5
BMI	0.4	2.4	8.5	0.3	2.9	1.8	1.4	0.7	2.3	0.3	-0.3	-0.3	2.7	1.4	1.4	1.0
Height	0.7	13.1	40.6	-3.4	-1.6	-5.0	-3.0	-0.9	-4.5	-3.7	-0.7	-3.5	-3.9	-3.9	-6.4	-2.0
Waist Hip Ratio (WHR)	0.2	0.9	2.5	0.3	0.6	-0.8	-1.0	0.8	-1.4	-1.6	1.4	-0.1	-0.9	-0.4	-1.4	-0.5
Systolic Blood Pressure	1.0	5.0	12.5	-0.8	-2.5	0.5	-3.3	0.6	-3.5	-2.4	0.2	-1.5	-3.5	-1.7	-1.6	-2.9
Smoking Status	0.3	0.8	3.1	1.7	-1.8	-0.1	-0.6	0.4	0.1	-0.2	0.7	1.2	0.5	-0.0	0.1	-1.2
Allergy or Eczema	1.0	2.6	7.0	-1.8	1.6	0.3	2.6	-0.3	2.2	1.8	-0.8	-0.6	2.1	1.5	1.8	1.5
Cardiovascular Disease	1.3	4.4	11.0	-1.1	-2.9	1.0	-3.1	-0.2	-2.8	-1.8	1.3	-2.0	-2.5	-1.3	-1.3	-3.3
Hypothyroidism (self reported)	0.2	0.5	2.8	0.8	-0.2	0.9	0.1	0.3	0.8	-0.4	-0.8	0.1	1.7	0.3	0.5	0.5
Respiratory disease	1.3	2.8	8.5	-0.8	2.9	0.1	2.9	1.0	2.4	0.5	0.6	-0.4	1.6	1.9	1.2	2.0
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.5	0.1	1.3	-0.3	1.0	-0.5	1.9	0.2	0.5	0.3	1.4	0.9	0.8	0.8
Lung FEV1/FVC ratio	0.4	1.9	14.7	-0.4	0.2	-0.9	0.0	-3.8	1.3	0.7	-1.4	0.5	0.5	-0.1	2.2	0.1
Lung FVC	1.3	6.9	17.6	-0.2	0.4	3.2	2.9	2.6	2.4	4.2	-0.5	-0.4	3.5	3.2	2.6	3.2
Neuroticism	0.3	0.7	3.6	0.5	0.6	0.1	-0.2	1.4	-0.4	-1.9	0.1	0.6	-0.1	-0.5	-0.7	-1.3
Chronotype (morning person)	0.3	0.7	1.6	0.5	0.8	-0.3	-1.0	-0.9	-0.8	-1.1	-0.5	0.4	-0.8	-1.0	-1.3	-0.7
Hair Pigment	0.1	2.9	6.7	-2.6	2.0	-2.1	-1.1	-1.1	-1.7	-1.9	1.8	-2.5	-1.1	-0.4	-1.6	-1.1
Tanning	0.3	3.1	11.4	3.4	-1.1	2.8	0.6	2.8	0.7	-1.0	-1.5	2.4	1.4	0.7	0.5	-0.0
Hand grip strength (left)	0.3	0.7	2.6	-0.2	0.4	1.6	0.8	1.6	0.0	0.9	0.1	-0.1	0.7	0.6	-0.1	1.3
Number of treatments/medications taken	0.5	0.9	2.5	-0.8	1.6	0.9	1.2	0.3	0.8	1.3	1.1	-0.7	0.8	0.9	0.6	0.7
Average weekly spirits intake	0.5	0.6	2.2	-0.1	-1.4	1.0	0.5	1.0	0.2	0.0	1.5	-0.3	0.1	0.9	0.8	-0.5
Sensitivity / hurt feelings	1.0	1.7	7.7	0.7	-0.2	-1.5	-1.2	0.2	-0.8	-2.8	0.1	1.2	-0.4	-1.5	-2.2	-1.0
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.9	0.5	-1.1	0.1	-1.2	0.1	-1.2	-1.7	-0.9	-0.3	-0.8	-0.8	-1.2	-0.4
Hearing difficulty/problems: Yes	0.7	1.1	3.1	-0.8	0.8	0.8	1.8	-0.4	1.5	1.3	-0.5	-0.3	1.2	1.1	1.2	0.5
Relative age of first facial hair	0.4	0.8	6.1	-0.3	0.1	-1.3	-0.5	-0.0	-0.7	0.3	2.5	0.5	-0.8	-0.1	-0.5	-0.3
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	8.7	0.3	3.0	-1.0	1.7	0.4	1.6	0.9	1.0	1.1	1.0	0.2	0.3	0.1
Ever used hormone-replacement therapy (HRT)	2.0	2.6	5.4	0.5	0.2	1.6	1.8	2.0	2.2	1.5	0.6	0.4	2.0	2.3	2.0	1.6
Ever had hysterectomy (womb removed)	0.4	0.4	2.8	-0.1	0.1	-0.0	-0.4	0.5	-0.7	-0.1	1.7	-0.5	-0.0	0.1	-1.2	0.0
Systolic blood pressure, automated reading	0.2	0.6	3.4	0.5	-0.4	0.6	-1.3	0.1	-0.6	-0.7	-0.2	0.3	-0.5	-0.7	-0.3	-1.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	2.2	-0.6	-0.7	0.1	-0.3	-0.9	0.6	-1.5	0.2	0.1	-0.3	-0.1	0.4	0.0
Angina	0.5	0.6	2.8	0.3	1.7	-0.1	0.6	-0.8	0.8	-0.6	0.1	0.7	0.4	0.3	1.3	-0.6
Medication for hormone replacement therapy	0.4	0.4	1.0	-0.9	-0.2	-0.2	0.2	-0.8	-0.2	0.4	1.0	-0.9	-0.9	0.2	0.5	-0.7
Vitamin and mineral supplements	0.6	0.8	3.1	1.8	-0.9	-0.4	-1.0	-0.4	0.0	-1.7	-0.0	1.3	-0.6	-0.5	0.2	-0.4
Supplements: Zinc	0.8	0.9	3.4	-1.7	0.1	-1.4	0.4	-0.2	-0.3	0.8	1.8	-1.2	0.5	0.5	-0.0	0.5
Medication: Co-codamol	0.8	0.9	1.8	0.4	0.1	0.7	1.1	1.3	1.4	0.1	-1.1	0.4	1.0	1.2	1.1	1.3
Medication: Metformin	0.6	0.9	2.6	-0.9	0.4	-0.4	1.0	-0.8	1.6	-0.9	0.8	-0.4	0.9	1.1	1.1	1.1
Diabetes (father)	0.6	0.8	3.0	0.6	-0.5	1.2	0.9	0.3	1.0	0.3	1.4	0.0	0.5	1.7	0.8	0.5
Diabetes (mother)	0.2	0.3	1.2	-0.0	0.6	0.4	-0.2	-0.1	-0.1	1.1	-0.0	-0.7	-0.2	0.7	0.4	1.0
Severe depression (siblings)	0.2	0.3	1.5	-0.2	0.3	0.3	0.6	1.2	-0.1	0.8	-0.0	-0.1	0.5	0.2	-0.1	0.6
Pack years adult smoking proportion	0.1	0.1	0.3	0.6	0.0	0.3	-0.1	-0.2	-0.0	0.4	0.2	0.4	0.1	-0.1	0.1	-0.5
Impedance of leg (right)	1.2	5.9	22.2	-0.8	-0.0	3.6	2.6	-1.5	2.8	2.8	-0.0	-0.7	0.8	3.4	4.7	1.5
Leg fat-free mass (left)	0.5	2.6	11.6	-0.6	0.8	-2.3	-0.9	1.3	-1.4	-2.5	-0.7	-1.1	-0.2	-1.8	-3.4	-0.1
Trunk fat percentage	1.0	4.0	10.2	-0.9	2.9	1.6	2.6	-0.1	3.2	0.7	-0.2	-1.4	2.6	2.3	2.6	1.3
Hand grip strength (right)	0.3	0.9	2.7	-1.2	0.6	1.1	1.2	0.9	0.3	0.7	-0.7	-1.2	0.5	0.9	0.1	1.7
Townsend deprivation index at recruitment	2.0	2.8	6.0	-0.5	-2.3	-1.1	-2.4	-2.2	-2.0	-0.7	0.8	-0.7	-1.8	-1.5	-1.5	-2.2
Current tobacco smoking	0.2	0.3	1.9	0.3	-1.4	0.1	0.2	0.3	0.4	0.0	0.8	0.3	0.8	0.7	0.2	-0.4
Average weekly fortified wine intake	0.7	0.8	4.0	-0.5	-0.2	0.4	-1.0	0.3	-1.0	0.0	1.2	-1.2	-0.6	-0.3	-2.0	0.9
Maternal smoking around birth	0.3	0.4	1.9	0.1	0.9	-0.2	0.3	1.0	0.1	-0.3	1.4	0.2	0.5	-0.1	-0.8	0.5
Fed-up feelings	0.6	1.0	3.6	1.5	-0.9	-0.0	-0.6	1.0	-0.6	-1.3	0.0	1.4	-0.9	-0.5	-0.6	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	4.0	1.7	1.1	-0.3	0.3	0.5	0.6	-1.3	-2.0	1.6	0.8	-0.6	0.2	0.1
Relative age voice broke	0.4	0.6	1.6	0.6	1.2	-1.3	-0.7	-0.4	-0.6	0.1	0.9	0.7	-1.0	-0.5	-0.6	-0.5
Taking other prescription medications	0.9	1.3	8.5	0.6	2.9	-0.7	1.6	0.3	1.6	0.5	-0.1	0.7	1.2	0.5	0.3	0.7
Age when periods started (menarche)	0.5	1.3	3.5	-0.9	-1.3	-1.1	-1.1	-0.5	-1.2	-0.5	1.9	-0.8	-1.1	-1.1	-1.1	-1.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.4	0.5	-1.8	0.6	-1.2	0.4	-1.2	-0.6	0.2	0.1	-0.9	-0.1	-0.4	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.2	-0.6	-1.0	0.7	-0.5	-0.6	0.0	0.4	1.1	-0.6	0.1	-0.5	-0.5	0.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.9	-1.2	0.9	0.5	0.8	0.4	-0.2	1.4	0.2	-1.3	-0.0	1.0	0.2	0.6
Qualifications: CSEs or equivalent	0.5	0.7	1.8	1.0	-0.9	1.4	0.5	0.4	0.6	0.5	0.8	0.8	0.9	0.8	1.0	0.3
Serious illness, injury or assault to yourself	0.5	0.7	4.2	-0.4	0.7	-0.9	-0.4	0.5	-1.0	-0.1	0.0	-0.9	-0.4	-0.6	-2.0	0.5
High blood pressure	1.5	4.2	15.0	-1.1	-1.8	0.4	-2.9	-0.4	-2.8	-1.6	1.2	-1.6	-2.7	-1.8	-1.2	-3.9
Hayfever, allergic rhinitis or eczema	0.6	1.4	4.7	-2.2	0.4	-0.4	1.4	-1.5	1.0	0.5	-1.4	-1.2	0.9	0.5	1.2	1.2
Multivitamins +/- minerals	1.2	1.6	6.4	-2.5	0.6	0.6	1.6	0.9	0.2	2.0	-0.1	-1.9	0.7	0.9	0.2	0.9
Stomach or abdominal pain in last month	0.6	0.8	1.7	-0.8	-0.8	1.2	0.5	1.2	0.5	-1.3	-0.1	-1.3	0.7	0.9	0.3	0.5
Supplements: Glucosamine	0.3	0.4	1.1	-0.8	0.6	-0.6	1.0	0.2	0.4	0.4	0.0	-0.3	0.8	0.7	0.9	-0.2
Diverticular disease/diverticulitis (self-reported)	6.0	7.1	15.5	1.6	1.5	3.9	3.4	2.9	3.1	1.6	-1.1	1.0	2.5	3.3	3.8	2.7
Medication: Atenolol	1.9	2.4	6.0	-1.8	-0.9	-0.7	-1.5	0.6	-2.2	-0.2	1.6	-2.4	-1.6	-0.8	-1.6	-2.0
Medication: Levothyroxine sodium	1.0	1.6	8.9	0.6	0.4	3.0	0.9	1.1	1.4	0.3	-0.5	-0.2	1.4	1.4	1.8	0.3
Sitting height	0.2	1.7	4.4	-2.1	-1.6	-1.5	-0.4	-0.1	-1.1	-0.9	-1.2	-1.7	-1.2	-1.0	-1.7	0.6
Chronic bronchitis/emphysema (father)	1.0	1.1	4.3	-1.4	-0.6	-0.1	-0.8	0.2	-1.4	-0.3	2.1	-1.8	-0.7	-0.3	-1.0	-0.5
High blood pressure (mother)	1.4	1.9	4.7	-0.2	-1.8	0.1	-1.7	-1.8	-1.4	-2.2	-0.1	0.1	-1.6	-1.7	0.0	-1.9
Body mass index (BMI)	0.7	2.8	9.5	-1.0	3.1	1.3	2.0	0.9	2.4	0.3	-0.6	-1.1	2.6	1.3	1.3	1.5
Impedance of leg (left)	1.0	4.8	17.2	-1.1	-0.9	3.6	2.2	-1.1	2.4	2.6	0.2	-1.2	0.7	3.1	4.1	1.1
Leg predicted mass (left)	0.5	2.6	11.6	-0.6	0.8	-2.3	-1.0	1.2	-1.4	-2.4	-0.7	-1.1	-0.2	-1.8	-3.4	-0.1
Trunk fat mass	0.6	2.6	8.0	-1.2	2.8	1.1	2.0	0.4	2.4	0.0	-0.5	-1.7	2.2	1.5	1.4	1.1
Waist circumference	0.4	1.4	7.4	-1.1	2.7	0.1	1.4	0.8	1.3	-0.5	-0.2	-1.3	1.7	0.4	0.1	0.9
Number of incorrect matches in round	3.3	5.6	11.1	0.1	-1.6	-2.4	-2.9	-0.3	-3.3	-2.5	3.0	0.5	-1.8	-2.4	-3.2	-3.2
Past tobacco smoking	0.2	0.3	1.6	-1.3	0.3	-0.6	0.0	-0.5	-0.4	-0.5	0.4	-0.4	-0.9	-0.3	-0.6	0.2
Alcohol usually taken with meals	0.3	0.5	1.8	-1.3	0.2	-0.8	-0.4	-0.6	-0.4	0.6	-0.3	-1.3	-0.6	-0.0	-0.2	0.7
Nervous feelings	0.4	0.7	2.0	-0.5	1.1	1.1	1.1	1.0	0.8	0.0	-0.5	-0.4	0.8	1.1	1.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.4	-1.2	0.3	0.3	0.6	0.2	-0.2	0.5	-1.6	-0.9	0.5	-0.2	-0.2	0.6
Hearing difficulty/problems with background noise	0.5	0.8	2.7	-1.5	1.0	-0.1	0.9	-0.8	0.2	1.6	-0.3	-1.2	-0.5	0.1	0.9	-0.2
Hair/balding pattern: Pattern 2	0.7	1.0	3.7	1.3	-0.4	-0.5	-0.9	-1.1	-0.0	-1.9	-1.2	1.3	-0.4	-0.6	-0.1	-0.9
Had menopause	4.2	5.3	18.4	0.5	4.3	0.4	3.0	2.3	2.5	3.3	0.7	0.8	2.8	1.9	1.8	1.3
Had other major operations	1.5	1.8	4.9	-0.9	1.5	1.3	1.6	2.1	1.3	0.6	-0.3	-0.6	1.4	1.4	0.8	2.2
Forced vital capacity (FVC)	0.2	0.6	2.6	-1.1	-0.3	0.2	0.6	0.5	0.0	1.6	-0.2	-1.1	0.9	0.4	-0.1	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.3	-1.2	-0.6	0.7	-0.2	-0.9	0.4	0.3	-0.0	-1.0	-0.3	-0.6	0.0	0.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.7	0.7	-0.1	0.8	1.4	0.3	1.7	-0.9	0.5	1.1	1.5	1.0	1.4	-0.1
Qualifications: None of the above	0.7	1.5	7.2	1.5	1.7	-0.2	-0.2	1.6	0.6	0.8	2.7	1.4	1.0	0.5	0.2	-0.7
Financial difficulties in last 2 years	0.2	0.2	0.9	-0.3	-0.8	-0.1	0.6	-0.5	0.4	-0.9	-0.2	0.4	-0.6	0.1	0.0	-0.4
Mouth/teeth dental problems	0.3	0.5	1.3	0.2	0.1	-0.1	-0.8	0.4	-1.0	-0.7	-1.1	0.1	-1.0	-1.1	-0.2	-0.5
Heart attack	0.3	0.4	1.5	-0.2	0.7	1.0	0.5	0.2	0.3	0.9	0.5	-0.0	-0.2	0.3	1.2	-0.8
Allergy	0.8	1.7	4.4	1.2	-1.7	-0.2	-1.9	0.3	-1.5	-0.3	1.4	0.8	-1.7	-1.2	-1.1	-2.1
Pain all over the body in last month	1.9	2.0	11.0	-1.2	1.5	0.2	1.8	0.6	1.2	3.3	0.6	-1.0	1.5	1.1	0.6	1.2
Diabetes (self-reported)	0.3	0.4	0.9	0.9	0.4	-0.8	0.1	-0.6	0.8	-0.4	0.9	0.8	0.6	0.3	0.5	-0.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	7.9	0.3	-0.1	-0.1	1.1	-2.8	2.1	-0.4	-1.7	1.0	-0.1	1.3	1.9	1.1
Medication: Ramipril	0.6	0.8	2.9	-0.5	-0.1	1.7	0.8	1.2	0.7	0.8	0.4	-0.9	0.9	0.6	1.1	-0.5
Medication: Simvastatin	0.3	0.4	1.2	-0.3	1.0	0.8	-0.5	-0.3	-0.5	0.9	1.1	-1.0	-0.3	-0.2	-0.3	-0.5
Fluid intelligence score	1.2	2.5	5.7	-0.4	2.0	1.4	2.3	0.1	1.9	2.0	0.1	0.4	1.2	1.8	2.4	1.6
Illnesses of siblings	0.4	0.6	4.8	-0.2	-0.7	-1.0	-0.1	-0.7	-0.1	-0.1	-2.2	0.1	-0.3	-0.6	-0.5	0.6
Neuroticism score	0.5	1.0	6.3	0.6	0.3	-0.4	-0.3	0.6	-0.3	-2.5	-0.4	0.7	-0.1	-0.9	-1.0	-1.6
Weight	0.3	1.3	4.6	-1.7	2.1	-0.3	1.0	0.8	0.8	-1.0	-0.7	-1.9	1.1	0.1	-0.6	0.8
Impedance of arm (right)	0.2	1.1	4.3	0.6	-1.0	0.5	-0.0	-1.6	0.5	0.8	1.1	0.5	-1.0	1.1	2.1	-1.3
Arm fat percentage (right)	1.0	3.8	11.0	-1.0	3.3	2.0	2.2	-0.3	2.9	0.7	-0.2	-1.2	2.5	1.9	2.7	1.2
Trunk fat-free mass	0.5	3.0	13.9	-1.1	0.7	-2.1	-1.1	1.0	-1.9	-2.4	-0.9	-1.2	-0.7	-2.1	-3.7	0.2
Hip circumference	0.4	1.7	7.6	-0.7	2.8	-0.2	1.8	0.0	2.0	0.5	-0.5	-0.7	1.8	0.7	0.9	1.1
Time employed in main current job	0.4	0.4	2.0	-1.3	-0.1	-0.0	-0.3	-1.4	-0.1	0.4	-0.5	-0.8	-0.6	-0.4	-0.6	0.2
Alcohol intake versus 10 years previously	0.8	1.2	4.0	0.7	0.7	1.3	0.4	2.0	0.8	-0.3	0.4	0.2	1.2	1.7	1.7	-0.8
Father’s age at death	1.6	2.1	5.4	-0.2	-0.8	-1.8	-1.6	-1.2	-1.9	-0.7	-0.3	-0.2	-1.8	-1.9	-2.3	-1.8
Worrier / anxious feelings	0.5	0.9	2.8	-0.2	1.4	0.5	1.7	1.0	1.1	0.3	-0.3	-0.0	1.6	0.7	0.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.4	-1.0	-0.8	-0.2	0.9	0.2	1.1	-0.7	-1.2	-1.1	1.2	0.1	0.3	0.4
Falls in the last year	0.5	0.6	2.2	-0.6	1.5	-0.3	1.0	0.7	0.6	0.4	0.5	-0.8	1.4	0.4	-0.7	0.1
Hair/balding pattern: Pattern 3	0.7	1.1	2.6	0.6	-0.7	1.4	1.5	0.6	1.5	1.6	0.1	0.8	1.2	0.4	1.2	-0.0
Number of live births	0.9	1.2	4.6	-0.5	1.4	1.0	1.5	0.7	1.2	2.1	0.3	-0.9	1.1	1.0	0.6	0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.0	-1.1	-0.0	0.8	0.9	-0.3	0.6	1.7	-1.2	-1.1	1.1	0.6	1.0	1.4
Pulse rate	0.3	0.5	2.9	-0.1	-0.2	-0.5	0.5	0.6	0.9	-0.4	0.6	-0.4	1.7	0.5	-0.6	0.4
Happiness	0.8	1.0	5.1	2.3	0.2	0.9	0.4	0.8	0.8	0.3	0.4	1.4	0.4	1.4	1.1	0.7
Noisy workplace	0.7	0.8	5.3	0.7	2.3	-0.5	0.2	1.4	-0.5	-0.3	0.6	-0.1	0.6	0.3	-1.2	0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.8	0.1	-0.9	-2.0	-0.4	-1.4	-0.4	0.8	0.0	0.2	-0.9	-1.2	-0.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	5.8	-0.6	-0.1	-1.9	-0.4	-2.4	0.3	-0.6	-1.0	-0.1	-0.8	-0.4	0.0	1.1
Mouth/teeth dental problems: Dentures	0.6	1.0	3.3	0.7	-1.8	0.3	1.0	0.5	1.4	1.3	0.8	0.8	1.6	0.5	0.1	0.2
Asthma	0.3	0.6	1.7	0.9	1.3	-1.0	0.7	0.9	0.3	-0.4	0.5	0.5	1.0	-0.1	-1.1	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	9.4	-0.5	0.0	0.5	0.2	-0.7	-0.0	-0.6	-3.1	0.2	-0.3	-0.4	0.1	0.2
Medication: Cholesterol lowering	0.4	0.6	2.4	-1.2	0.7	1.0	-0.2	-0.2	-0.3	0.3	0.6	-1.6	0.3	-0.6	-0.6	-0.9
Depression (self-reported)	0.4	0.5	4.7	0.1	2.2	-0.2	0.3	0.0	0.2	0.0	0.5	0.6	-0.2	-0.7	-0.0	0.8
Medication: Lansoprazole	1.2	1.3	4.7	0.8	1.5	-1.1	-0.1	1.9	-0.5	-0.8	0.6	0.6	0.2	-1.2	-2.2	-1.2
Prospective memory result	1.2	1.5	4.2	-0.3	-1.3	-1.6	-1.3	0.3	-2.0	-0.7	1.5	-0.8	-0.8	-0.4	-1.9	-1.1
Lung cancer (father)	0.3	0.3	1.2	1.1	-0.4	0.2	0.1	0.0	0.5	0.6	0.8	0.9	0.6	-0.1	0.1	-0.5
Illnesses of mother	1.1	1.3	2.8	1.1	0.8	0.5	0.9	1.6	1.1	1.7	-1.1	0.7	1.6	1.6	0.0	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.6	-1.0	0.8	0.8	1.2	-0.5	0.7	2.1	-1.8	-0.8	1.2	1.0	1.5	1.7
Pulse wave Arterial Stiffness index	0.2	0.2	1.1	0.7	-0.2	-1.0	-0.1	-0.5	0.3	0.2	-0.3	0.8	-0.1	-0.6	-0.1	-0.1
Impedance of arm (left)	0.2	1.1	5.0	0.6	-1.1	0.4	0.1	-1.6	0.7	0.5	0.8	0.5	-0.9	1.0	2.2	-1.1
Arm fat mass (right)	0.5	2.0	7.9	-1.4	2.8	0.9	1.5	0.2	1.8	-0.2	-0.4	-1.6	1.8	1.0	1.0	1.0
Trunk predicted mass	0.5	3.0	14.4	-1.0	0.6	-2.1	-1.1	1.0	-1.9	-2.4	-1.0	-1.2	-0.6	-2.2	-3.8	0.2
Standing height	0.6	5.7	17.9	-1.9	-1.5	-3.4	-1.8	-0.0	-3.0	-2.8	-0.4	-2.2	-2.6	-2.4	-4.2	-1.0
Length of working week for main job	0.5	0.6	2.7	-0.0	-1.2	-0.8	-0.5	-0.2	-0.4	0.1	1.6	-0.9	-0.0	-0.2	-1.3	-0.2
Exposure to tobacco smoke at home	0.7	0.7	2.7	0.6	-0.4	1.0	-1.2	-1.3	-0.8	0.3	-0.3	0.1	-1.6	-0.0	0.2	-1.3
Breastfed as a baby	0.3	0.4	2.0	-0.4	0.4	0.7	0.1	0.6	-0.0	0.2	-0.8	-0.9	0.3	0.1	-0.1	1.4
Tense / ‘highly strung’	0.2	0.3	3.0	0.1	0.1	0.2	0.0	-0.1	0.0	-1.7	0.8	0.1	-0.1	-0.1	-0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.4	0.2	0.9	-0.2	1.4	-0.9	1.6	-0.3	-0.1	1.5	0.7	0.5	1.5	0.7
Hair/balding pattern: Pattern 4	0.5	1.2	5.6	2.4	0.1	0.7	0.5	0.4	0.8	0.5	-1.6	2.3	0.1	-0.1	0.9	0.2
Birth weight of first child	1.1	2.1	8.9	-1.9	1.9	-3.0	-0.2	-0.1	-1.1	0.5	1.4	-1.3	-0.0	-1.0	-2.1	0.4
Peak expiratory flow (PEF)	0.9	2.0	4.8	-2.2	-1.4	2.1	-0.2	-2.0	0.1	-0.4	-2.2	-1.8	-0.3	-0.1	1.7	0.5
Pulse wave reflection index	1.2	1.5	4.7	1.0	2.2	0.8	1.6	0.9	1.3	1.1	0.0	1.1	1.0	1.1	1.3	1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.6	1.3	0.5	-0.7	-0.1	-0.3	0.0	0.0	0.1	1.1	0.2	-1.2	-0.3	-1.2
Loud music exposure frequency	0.6	0.6	2.0	0.3	-1.4	0.4	-0.9	-0.7	-0.9	-0.7	0.1	0.3	-1.4	-0.6	-0.0	-1.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	3.7	0.6	0.1	-0.4	0.1	-0.3	-0.0	0.7	-1.9	0.2	-0.7	0.1	-0.1	1.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	-0.2	0.1	-0.7	-0.6	-0.3	-0.9	-0.2	0.6	-0.4	-0.8	0.2	-0.9	-0.2
Blood clot in the leg (DVT)	1.1	1.4	3.1	1.8	0.3	1.6	0.6	1.2	0.5	0.9	0.4	1.2	1.3	1.7	1.3	1.1
Medication: Paracetamol	1.4	2.3	5.6	-1.6	2.0	0.6	2.4	0.8	1.8	0.3	-0.5	-1.1	1.3	1.8	2.1	1.7
Headache pain in last month	0.3	0.6	1.9	-0.3	-0.1	1.0	0.9	0.6	1.1	-0.6	0.0	-0.6	0.7	1.4	0.9	0.7
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	3.5	1.2	-0.3	-1.7	0.5	-0.4	0.8	-0.9	-0.5	1.9	-0.2	0.5	0.6	1.1
Glaucoma (self-reported)	1.2	1.4	6.8	2.6	-0.2	1.0	0.2	0.2	1.2	-1.4	-0.6	2.3	0.3	0.2	1.1	-0.6
Gout (self-reported)	1.3	1.8	8.1	2.8	0.2	1.5	-0.3	-0.5	0.3	-0.1	-0.9	2.9	-0.3	-0.3	0.5	-1.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.1	1.1	0.3	1.4	0.3	-0.2	1.0	0.4	-1.5	0.7	1.1	0.5	1.1	0.0
Medication: Amlodipine	0.5	0.7	2.9	0.7	0.8	1.0	0.5	0.9	-0.1	1.6	1.7	0.3	0.2	0.5	0.1	-0.3
Medication: Ventolin 100micrograms inhaler	2.0	2.5	7.6	-0.0	2.1	0.1	2.1	1.3	1.8	1.1	-0.3	-0.4	2.8	1.8	0.4	2.5
Birth weight	0.7	1.4	3.6	1.5	-1.8	-0.1	-1.2	1.5	-1.3	-1.0	-0.5	0.6	-0.5	-0.8	-1.3	-1.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.4	1.1	-1.0	0.2	0.0	1.0	0.2	-0.7	0.7	0.3	1.2	0.5	-0.6	0.1
High blood pressure (siblings)	0.4	0.5	3.5	0.1	0.1	1.9	0.2	1.1	0.3	0.1	0.1	-0.1	-0.1	0.7	1.2	0.2
Forced vital capacity (FVC), Best measure	0.3	1.1	4.1	-1.3	0.1	0.4	0.9	0.4	0.2	2.0	-1.0	-1.2	1.0	0.9	0.7	1.6
Body fat percentage	1.6	6.2	14.3	-1.2	3.4	2.6	3.1	-0.0	3.8	1.3	-0.3	-1.6	3.1	2.8	3.4	1.8
Leg fat percentage (right)	2.6	9.5	20.6	-1.5	3.4	3.9	3.8	-0.2	4.5	2.2	-0.7	-1.4	3.6	3.6	4.5	2.5
Arm fat-free mass (right)	0.4	2.1	10.3	-0.8	0.7	-1.4	-0.5	1.4	-1.1	-2.1	-1.1	-1.3	0.3	-1.4	-3.2	0.6
Exposure to tobacco smoke outside home	0.5	0.6	1.6	1.1	-0.6	0.5	-0.7	0.5	-0.6	-0.5	-1.0	0.9	-0.9	-0.7	-0.0	-1.3
Comparative body size at age 10	2.6	7.2	15.3	1.8	-0.6	-2.6	-3.8	-2.1	-3.1	-1.8	0.6	1.7	-2.5	-3.9	-3.8	-3.6
Number of full brothers	0.7	0.9	3.7	-0.5	0.3	-0.9	-1.0	0.8	-1.9	-0.4	1.5	-0.5	-0.6	-0.1	-1.5	-0.3
Worry too long after embarrassment	1.1	1.8	5.3	-1.1	-1.2	-1.7	-1.1	-0.7	-1.4	-1.4	-0.8	-0.9	-1.0	-1.8	-2.3	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	4.7	-0.3	0.1	-1.4	0.5	-1.7	1.0	-2.2	-0.4	0.8	-0.1	-1.1	0.0	-0.3
Wheeze or whistling in the chest in last year	0.6	1.0	2.6	-1.6	1.0	-0.0	1.3	0.9	0.8	-0.9	-0.2	-1.6	1.3	1.0	-0.3	0.7
Number of children fathered	0.5	0.6	2.4	-0.5	-0.3	-0.5	0.4	1.3	0.4	-1.0	-0.1	-0.3	1.2	0.2	-0.5	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	5.8	-0.1	-0.4	0.6	-1.2	-1.7	-1.0	-2.0	-2.4	-0.6	-1.4	-1.2	0.0	-1.0
Age at first live birth	3.7	6.6	13.2	-1.6	-2.2	-2.1	-3.1	-2.6	-3.1	-3.1	-2.1	-0.6	-3.6	-3.1	-2.5	-2.0
Pulse wave peak to peak time	0.2	0.2	0.9	-0.5	0.0	0.9	-0.0	0.5	-0.4	-0.4	-0.0	-0.8	-0.0	0.5	-0.0	0.0
Health satisfaction	0.8	1.1	8.2	1.0	2.9	-0.8	0.3	0.7	-0.0	0.2	0.2	1.5	0.2	-0.5	-0.7	0.4
Shortness of breath walking on level ground	0.4	0.5	2.0	0.2	1.4	-1.4	0.3	-0.1	0.2	-0.3	0.5	0.2	0.3	-0.0	-0.6	1.0
Qualifications: College or University degree	1.4	4.5	11.8	-2.1	-1.1	-2.4	-2.2	-2.5	-2.4	-1.2	0.6	-1.1	-3.4	-2.9	-2.7	-0.4
Eye problems/disorders: None of the above	0.7	0.8	2.2	0.3	-0.8	0.7	0.8	-0.8	0.9	1.5	-0.3	0.7	0.9	1.3	0.7	1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.8	3.1	-1.8	-0.3	1.4	0.2	-0.7	0.1	-0.3	0.8	-1.7	-0.2	0.5	0.2	-0.2
Emphysema/chronic bronchitis	0.5	0.5	2.6	-1.0	1.6	0.0	0.7	0.5	0.4	-1.0	0.1	-0.8	0.2	0.5	0.5	0.1
Medication for pain relief, constipation, heartburn	1.0	1.8	3.6	0.9	-1.3	-1.7	-1.9	-0.3	-1.7	-0.7	1.5	0.6	-1.1	-1.4	-1.8	-1.5
Neck or shoulder pain in last month	0.6	0.8	7.3	-0.6	-0.7	-0.3	0.1	-0.7	0.3	-2.7	-1.0	0.0	-0.0	-0.3	-0.0	-1.0
Medication: Blood pressure	0.5	0.8	3.2	-0.4	-0.3	1.8	-0.7	1.1	-1.2	0.4	0.4	-1.5	-0.4	-0.2	-0.4	-1.1
Angina (self-reported)	0.4	0.5	2.7	0.2	1.6	-0.2	0.3	-1.0	0.4	-0.5	0.3	0.5	0.1	0.1	1.1	-1.0
Migraine (self-reported)	1.5	1.9	9.5	-2.7	1.0	-1.2	0.2	0.1	-0.5	-1.4	0.8	-3.1	-0.5	0.4	-0.9	1.3
Medication: Ibuprofen	0.6	0.8	4.4	-1.6	-0.1	-0.2	0.1	-0.8	-0.4	-0.5	-2.1	-0.7	-0.4	-0.7	-0.7	0.5
Medication: Allopurinol	1.1	1.4	8.0	2.4	0.7	0.7	0.3	-0.2	0.9	0.7	-0.7	2.8	0.1	0.2	1.1	-0.7
Medication: Omeprazole	0.9	1.1	3.1	1.7	0.9	0.8	0.6	-0.1	1.6	0.7	-0.1	1.8	1.6	0.1	0.5	0.6
Medication: Seretide 50 evohaler	0.4	0.4	2.3	-0.5	-0.8	-0.9	-0.4	0.1	-0.4	-1.5	-0.6	-0.0	0.0	-0.6	-0.6	-0.3
Mean time to correctly identify matches	0.2	0.5	1.9	-1.4	-0.6	-0.3	0.7	0.5	0.1	-0.7	0.4	-1.1	0.7	0.7	0.1	-0.1
Heart disease (mother)	1.1	1.4	3.6	-1.3	-0.8	-1.4	-0.4	-1.4	-0.9	-0.7	1.8	-0.4	-1.2	-1.9	-0.6	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	5.8	-0.2	-0.8	0.6	-0.4	2.4	-0.7	0.3	2.0	-1.0	0.6	0.6	-1.3	0.7
Whole body fat mass	0.9	3.8	10.0	-1.3	3.2	1.7	2.5	0.5	2.8	0.5	-0.8	-1.7	2.6	1.8	1.9	1.6
Leg fat mass (right)	1.1	4.4	8.9	-1.4	3.0	2.4	2.6	0.3	3.0	0.8	-0.8	-1.6	2.7	2.0	2.3	1.9
Arm predicted mass (right)	0.4	2.0	10.0	-0.9	0.7	-1.3	-0.4	1.5	-1.0	-2.0	-1.0	-1.5	0.2	-1.4	-3.2	0.6
Pulse rate, automated reading	0.7	2.2	6.4	-0.6	0.6	0.8	2.1	0.6	2.5	0.0	-0.1	-0.5	2.5	2.4	1.9	0.9
Alcohol intake frequency.	0.4	0.9	3.0	0.3	-0.2	0.7	1.2	0.6	1.7	0.5	1.0	0.7	1.5	1.0	0.2	1.2
Comparative height size at age 10	0.1	0.6	2.6	-0.8	-0.3	-1.4	-0.1	-0.2	-0.1	-0.6	0.2	-1.3	-0.4	-0.5	-1.6	-0.1
Number of full sisters	0.7	0.9	3.7	-1.9	-0.9	0.1	-0.2	-0.2	-0.3	-0.9	0.1	-1.6	-0.8	-1.1	0.1	-1.3
Suffer from ‘nerves’	1.3	2.0	6.7	0.6	-0.5	-0.8	-1.4	-1.5	-1.1	-2.6	-1.1	0.9	-1.2	-2.0	-1.2	-2.0
Overall health rating	1.4	3.0	8.2	0.4	2.9	0.5	2.3	1.3	2.2	1.3	1.5	0.7	2.6	2.1	1.6	0.9
Chest pain or discomfort	0.6	0.9	4.2	-1.1	2.0	-1.2	0.9	0.0	0.8	-0.4	0.4	-0.9	0.1	0.3	-0.1	1.3
Had major operations	1.1	1.3	5.7	-0.2	-1.4	-2.2	-0.3	-0.3	-0.5	-0.1	2.4	-0.3	0.5	-0.1	-1.6	-0.4
Age at last live birth	5.2	7.6	14.2	-1.7	-1.8	-2.6	-3.2	-2.4	-3.4	-2.6	-1.4	-1.2	-3.5	-3.8	-3.7	-2.7
Family relationship satisfaction	0.7	0.8	4.4	2.1	-0.2	0.1	-0.6	1.2	-0.9	-1.4	0.4	1.0	-0.4	0.4	-0.6	-0.2
Leg pain on walking	1.5	1.9	4.2	0.9	2.0	0.4	2.0	0.7	2.0	1.4	-0.9	1.3	1.8	0.8	-0.6	1.5
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	6.5	-1.1	1.2	0.4	2.6	-0.2	2.0	0.4	-1.8	-1.2	2.1	1.5	1.8	2.2
Commuting to job workplace: Car/motor vehicle	1.2	1.4	5.2	1.1	-1.6	2.3	0.5	-0.6	1.3	-0.9	-1.8	1.1	0.2	0.3	1.1	-0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.3	0.5	-0.2	0.4	-0.9	0.7	-1.0	0.4	0.6	0.5	-0.0	-1.1	-0.2	-1.5
Medication: Aspirin	0.4	0.5	1.2	-1.0	0.1	-0.3	-0.4	-1.1	-0.5	-0.2	0.7	-0.9	-0.8	-0.7	-0.8	-0.5
Supplements: Vitamin C	0.4	0.5	1.7	-1.1	1.3	0.1	1.0	-0.0	0.5	0.4	-0.5	-0.4	0.2	0.7	0.5	0.8
Knee pain experienced in last month	0.5	0.8	2.6	0.8	1.6	-1.1	1.0	-0.1	1.0	-0.4	-1.3	1.0	1.0	-0.1	-0.5	0.1
Hypertension (Self-reported)	1.4	3.9	14.7	-0.6	-1.6	0.5	-2.9	-0.1	-2.8	-1.5	1.4	-1.3	-2.5	-1.8	-1.3	-3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.5	-0.2	0.6	0.9	0.3	0.7	0.0	-0.9	1.3	-0.6	1.1	0.9	-0.2	1.6
Illnesses of father: Heart disease	0.3	0.4	2.0	1.3	-0.5	-0.1	-0.2	-0.1	0.1	-0.3	0.4	1.4	0.5	0.1	-0.5	0.3
Illnesses of siblings: Diabetes	1.0	1.3	7.4	0.1	1.6	1.4	0.5	0.2	0.3	0.2	2.7	-0.4	-0.4	1.8	0.9	0.1
Smoking status: Previous	0.3	0.5	2.5	1.6	-0.9	0.5	-0.5	0.6	0.1	-0.2	0.0	0.7	0.5	-0.4	0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	5.3	-1.2	-1.6	-2.3	-2.0	-1.3	-2.2	-1.4	0.5	-0.9	-2.0	-1.7	-2.1	-1.2
Whole body fat-free mass	0.5	3.0	14.5	-1.0	0.8	-2.2	-1.0	1.4	-1.7	-2.4	-0.8	-1.4	-0.4	-2.0	-3.8	0.2
Leg fat-free mass (right)	0.7	3.5	15.8	-0.5	0.2	-2.6	-1.4	1.5	-2.0	-2.7	-0.5	-1.1	-0.6	-2.2	-4.0	-0.5
Arm fat percentage (left)	1.0	3.9	10.8	-0.7	3.3	1.9	2.2	-0.1	3.0	0.6	-0.4	-1.0	2.6	2.0	2.8	1.2
Average weekly red wine intake	0.5	0.7	3.3	-0.3	-0.5	-0.2	-0.5	0.9	-0.7	1.1	-0.2	-1.1	0.8	-1.0	-1.8	-0.5
Handedness (chirality/laterality): Left-handed	1.7	2.0	6.9	-0.4	-0.1	-2.6	-1.5	-0.7	-1.9	-0.8	0.1	0.2	-0.8	-2.1	-2.4	-1.2
Mood swings	0.4	0.7	1.3	0.6	0.8	1.1	1.0	-0.1	1.2	-1.0	-0.6	0.6	1.0	0.7	1.1	-0.5
Loneliness, isolation	1.2	1.7	5.7	-0.5	1.2	1.1	2.4	0.6	2.1	-0.2	-0.2	0.0	1.5	1.7	1.5	1.0
Long-standing illness, disability or infirmity	1.2	1.9	8.1	0.6	2.8	-0.0	1.9	0.4	1.7	1.8	0.7	0.9	1.4	1.0	1.1	0.7
Ever had bowel cancer screening	0.7	0.8	2.7	1.4	-0.7	-0.2	-0.7	-1.2	-0.2	-1.2	-1.6	1.2	-0.5	-0.7	0.0	-0.5
Diabetes diagnosed by doctor	0.4	0.6	1.8	0.9	0.2	-0.8	0.3	-0.8	1.2	-0.7	0.9	1.3	0.8	0.2	0.6	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	-0.8	0.8	-1.0	0.8	-0.6	0.8	0.5	-0.4	-0.3	0.7	-0.1	-0.0	-0.1
Friendships satisfaction	0.3	0.4	1.3	0.5	0.4	0.5	-0.5	1.1	-0.6	-0.2	1.1	-0.1	0.3	0.1	-0.8	0.3
Qualifications: nursing, teaching	0.2	0.3	1.4	0.1	1.2	0.2	0.5	0.2	0.4	1.0	0.6	0.2	-0.3	-0.4	0.0	0.5
Commuting to job workplace: Walk	0.6	0.6	4.2	-0.1	0.3	-0.3	0.8	-0.7	0.7	2.0	0.4	0.2	0.7	0.9	0.5	0.7
Eye problems/disorders: Cataract	0.9	1.0	1.9	-0.3	1.2	-0.8	-0.5	1.0	-1.0	-1.4	-1.2	-1.1	-0.9	-1.1	-1.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.5	-1.1	0.4	-0.7	0.4	-0.1	0.3	0.0	1.2	-0.5	0.4	0.3	-0.3	0.2
Medication for cholesterol	1.2	1.8	6.0	0.9	1.0	1.2	1.5	0.5	1.9	-0.2	-1.2	1.1	2.0	1.1	0.5	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.3	-0.7	-0.1	0.9	-0.2	-1.2	0.1	-0.9	-1.1	-0.8	-0.6	-0.3	1.0	0.1
Back pain experienced in last month	0.6	0.9	2.7	0.4	1.4	-0.9	1.0	-0.0	1.2	0.6	-0.8	0.6	1.6	-0.2	-1.0	1.2
Mineral and other dietary supplements	0.4	0.5	1.4	1.0	-0.1	0.8	-0.4	0.7	0.1	-1.1	-1.2	0.5	-0.2	-0.5	-0.7	0.9
Breast cancer (self-reported)	1.2	1.4	6.7	-0.5	2.3	-0.7	0.0	0.7	-0.8	1.5	2.6	-0.6	0.5	0.3	-0.9	-0.7
Asthma (self-reported)	0.3	0.6	1.7	0.6	1.2	-1.3	0.5	0.7	0.2	-0.4	0.9	0.3	0.9	-0.2	-1.3	0.7
Osteoporosis (self-reported)	0.6	0.7	2.1	-0.6	0.7	1.5	1.1	1.1	0.8	0.3	-0.6	-1.1	0.8	0.4	0.6	0.5
Osteoarthritis (self-reported)	0.5	0.6	1.7	0.1	1.3	-1.3	0.2	1.2	-0.2	0.3	1.0	0.5	0.3	-0.4	-0.3	-1.3
Medication: Aspirin	0.3	0.4	1.0	-0.9	0.2	0.3	-0.3	-0.8	-0.5	0.4	0.8	-1.0	-0.4	-0.6	-0.8	-0.2
Medication: Gliclazide	0.5	0.5	1.7	-0.0	0.5	0.7	0.6	0.5	0.8	-0.8	-0.7	-0.1	0.4	1.1	1.3	1.0
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	0.4	0.9	-0.5	0.7	0.7	1.3	-0.0	-1.1	0.4	0.5	-0.1	0.5	0.7
Smoking status: Current	0.1	0.2	1.5	0.5	-1.2	-0.1	-0.1	0.1	0.2	-0.1	0.4	0.4	0.5	0.6	0.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.5	7.4	16.7	-0.3	2.1	3.2	3.4	1.5	2.9	3.7	-2.2	-0.0	3.0	2.9	4.1	2.6
Whole body water mass	0.5	3.0	14.5	-0.8	0.8	-2.2	-1.0	1.4	-1.7	-2.3	-0.9	-1.2	-0.2	-2.0	-3.8	0.2
Leg predicted mass (right)	0.7	3.5	15.7	-0.5	0.2	-2.7	-1.4	1.5	-2.0	-2.7	-0.5	-1.1	-0.5	-2.2	-4.0	-0.5
Arm fat mass (left)	0.5	2.2	8.1	-1.0	2.8	1.0	1.7	0.3	2.1	-0.1	-0.7	-1.3	2.1	1.2	1.3	1.1
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	0.8	0.9	0.3	0.5	-0.3	0.6	-0.4	0.5	0.7	-0.5	0.1	-0.2	-0.3
Average weekly champagne plus white wine intake	0.4	0.5	2.4	0.0	1.5	-0.7	0.2	0.1	-0.5	0.7	0.5	0.2	-0.7	-0.1	-1.2	1.0
Miserableness	1.3	2.3	4.5	2.0	0.3	1.1	1.9	1.4	2.1	0.1	-0.2	2.1	1.5	2.0	1.7	1.0
Guilty feelings	1.8	2.7	6.2	-0.7	-1.5	-1.4	-2.0	-0.9	-1.6	-1.8	0.3	-0.5	-2.1	-2.5	-2.1	-2.1
Wears glasses or contact lenses	0.4	0.5	1.5	-0.7	-0.5	-0.2	-0.3	-0.7	-0.0	-0.6	-1.2	-0.5	-0.6	-1.2	-0.2	-0.8
Ever taken oral contraceptive pill	0.4	0.4	1.1	-0.5	-0.8	0.8	-0.4	-0.3	-0.7	-1.0	0.5	-0.5	-0.2	-0.6	-0.2	-1.1
Hearing aid user	0.9	1.0	3.2	-0.7	1.6	1.4	0.6	1.8	0.4	0.5	-0.6	-1.2	0.9	0.7	1.1	0.5
Mother’s age at death	1.6	2.0	11.6	-3.2	-0.8	-0.1	0.1	-0.1	-0.6	-0.5	-0.8	-3.4	-0.7	0.8	0.7	0.3
Financial situation satisfaction	0.1	0.2	0.4	0.6	-0.2	0.1	0.4	0.2	0.5	-0.1	-0.6	0.4	-0.2	0.6	0.6	0.4
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	-1.0	-0.7	1.0	0.2	-0.5	-0.3	0.3	1.1	-0.6	-0.9	0.3	0.4	-0.5
Commuting to job workplace: Public transport	1.1	1.3	3.6	-1.6	0.6	-1.9	-1.1	-0.5	-1.6	-0.8	-0.0	-1.7	-1.1	-0.5	-0.9	0.2
Eye problems/disorders: Glaucoma	1.5	1.7	6.8	2.6	-0.2	2.0	0.4	1.7	1.1	-1.0	0.4	1.8	0.9	0.6	1.2	-0.6
Medication: Blood pressure	0.8	1.5	5.8	-1.7	0.2	-0.5	-1.0	0.1	-1.2	0.2	1.3	-1.8	-1.5	-0.3	0.2	-2.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	2.7	0.3	0.4	0.9	0.2	1.7	0.4	-0.4	-0.9	-0.0	-0.3	-0.3	-0.6	-0.1
Supplements: Fish oil (including cod liver oil)	1.3	1.6	3.5	-1.3	-0.5	-1.9	-1.2	-1.5	-1.8	-0.0	1.7	-1.2	-1.0	-1.0	-0.5	-1.7
High cholesterol (Self-reported)	0.4	0.7	2.8	-1.3	-0.7	0.8	-0.7	-0.0	-0.6	0.9	0.9	-1.7	-0.6	-0.1	0.3	-0.3
Medication: Bendroflumethiazide	0.5	0.8	2.0	-0.7	-0.3	-0.6	-0.9	0.9	-1.2	1.0	1.4	-1.0	-0.2	-0.5	-0.9	-1.0
Medication: Paracetamol	1.0	1.5	5.2	-2.3	1.2	-0.5	1.6	-0.1	0.9	-0.1	-0.1	-2.0	0.7	1.2	1.0	1.4
Medication: Lisinopril	0.4	0.5	2.0	-1.1	0.0	1.1	0.1	-0.4	-0.1	-0.1	-0.3	-1.0	-0.8	0.7	1.4	-0.1
Medication: Atorvastatin	0.4	0.5	2.1	-0.9	-0.1	0.6	0.1	0.6	-0.2	-0.1	-0.1	-0.4	-0.4	-0.4	1.4	-1.5
Illnesses of father: High blood pressure	0.3	0.4	1.6	0.5	0.1	0.6	-0.6	-1.1	-0.3	-1.3	-0.3	0.7	-0.6	-0.1	0.2	-0.8
Alcohol drinker status: Never	0.5	0.6	4.5	-0.3	-0.1	0.3	-0.5	0.5	-0.5	0.6	2.1	-0.3	-0.7	0.3	-0.9	0.1
Ever smoked	0.2	0.3	1.0	0.1	-0.6	1.0	0.3	0.3	0.5	0.3	0.0	-0.5	0.7	0.9	0.7	0.3
Basal metabolic rate	0.4	2.1	9.1	-1.2	1.1	-1.7	-0.5	1.2	-1.1	-2.1	-0.8	-1.6	-0.0	-1.5	-3.0	0.4
Leg fat percentage (left)	2.5	9.0	18.7	-1.6	3.1	4.0	3.7	0.4	4.3	2.1	-0.7	-1.8	3.6	3.5	4.2	2.5
Arm fat-free mass (left)	0.4	1.9	9.4	-1.1	1.1	-1.5	-0.3	1.3	-0.9	-1.7	-0.7	-1.5	0.4	-1.3	-3.1	0.9
Number of operations (self-reported)	0.4	0.7	2.3	-0.4	0.9	-0.8	0.8	1.5	0.3	0.8	1.3	-0.2	0.6	0.4	-0.4	0.9
Average weekly beer plus cider intake	1.9	2.7	5.5	-0.9	1.8	1.6	2.0	0.4	2.0	0.8	-1.6	-1.3	1.5	2.0	2.0	2.3
Irritability	0.4	0.6	2.6	1.2	-0.5	-0.6	-0.2	0.3	-0.0	-1.1	-0.9	1.6	0.4	-0.7	-0.4	-0.6
Risk taking	0.4	0.6	2.0	-1.4	-0.1	-1.3	0.8	0.4	0.5	-0.1	0.7	-0.9	0.6	-0.1	-0.6	0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	1.1	0.7	0.4	0.6	0.2	0.9	0.4	-0.2	1.0	1.0	0.6	0.0	0.7
Fractured/broken bones in last 5 years	1.0	1.3	3.5	1.3	0.3	-1.4	-1.1	-1.0	-0.9	-0.8	-0.2	1.8	-1.0	-1.2	-0.5	-1.9
Age started oral contraceptive pill	0.8	1.0	3.3	-0.3	1.3	-1.6	0.1	0.4	0.1	-0.4	1.8	-0.8	1.4	1.0	-1.1	0.9
Diastolic blood pressure, automated reading	0.6	2.0	6.6	-1.4	-1.5	0.1	-1.8	-0.3	-1.7	-1.6	-0.9	-1.6	-1.2	-1.1	-0.2	-2.6
Ever depressed for a whole week	0.7	0.8	2.5	-0.3	-0.3	1.1	1.4	0.1	1.5	0.2	1.0	-0.2	0.6	1.1	1.6	0.3
Unable to work because of sickness or disability	1.2	1.6	6.0	0.9	0.0	-0.8	2.0	1.1	1.8	1.2	0.4	1.1	2.5	0.9	0.6	0.8
Commuting to job workplace: Cycle	2.7	3.3	6.9	-0.4	-1.0	-2.2	-2.2	-1.2	-2.5	-2.0	0.3	-0.7	-2.6	-2.1	-2.2	-1.9
Myopia	1.0	1.4	6.5	-1.2	-1.7	1.3	0.5	-0.3	0.4	-0.5	-2.5	-0.5	0.1	0.3	1.1	1.7
Vascular/heart problems diagnosed by doctor	1.2	3.4	12.8	1.0	1.1	-0.2	2.5	0.3	2.5	1.2	-1.4	1.4	2.5	1.6	1.1	3.6
Cholesterol lowering medication	0.4	0.5	2.2	-0.0	-0.9	0.8	-0.8	-0.4	-0.5	0.1	0.2	0.1	-1.5	-0.3	1.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.5	1.4	1.0	-0.6	0.6	0.1	1.5	-0.5	-0.4	1.6	1.6	-0.3	-0.1	0.6
Pain experienced in last month	0.3	0.5	1.6	0.8	-1.2	0.3	-0.6	1.0	-0.8	0.6	1.2	0.1	-0.2	0.1	0.2	-0.3
Supplements: Calcium	0.2	0.2	1.0	-0.5	-0.1	-0.5	0.8	-1.0	0.4	-0.1	0.5	0.4	0.4	0.3	-0.0	0.5
Basal cell carcinoma (self-reported)	1.6	1.9	6.7	2.6	-0.9	2.4	0.1	1.0	0.6	1.0	-1.0	1.4	0.8	0.9	1.5	-1.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.6	-0.1	0.5	1.2	0.4	0.1	0.3	0.7	0.5	0.0	-0.3	0.4	1.3	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.8	1.5	0.5	1.6	0.5	1.4	0.3	1.0	0.9	0.7	1.5	1.7	1.1	1.2
Heart disease (siblings)	1.2	1.4	4.2	-0.0	1.0	0.8	1.1	0.6	0.8	1.3	2.0	0.1	1.5	1.7	1.7	1.0
Alcohol drinker status: Previous	0.8	0.9	3.1	1.4	0.1	-0.7	0.9	0.1	0.9	0.3	0.6	1.8	1.2	0.0	-0.6	1.4
Pack years of smoking	0.1	0.1	0.3	0.5	0.2	0.5	0.3	-0.2	0.3	0.6	0.2	0.4	0.3	0.1	0.3	-0.5
Impedance of whole body	0.4	2.1	9.5	-0.2	-1.3	2.0	1.0	-1.4	1.4	1.5	0.5	-0.3	-0.3	2.0	3.1	-0.2
Leg fat mass (left)	1.0	3.9	7.9	-1.4	2.8	2.3	2.4	0.6	2.8	0.8	-0.9	-1.7	2.6	2.0	2.0	1.8
Arm predicted mass (left)	0.3	1.7	7.5	-1.4	1.2	-1.1	-0.1	1.5	-0.7	-1.4	-0.6	-1.7	0.4	-1.0	-2.7	0.9