Hub : Genes

PARK2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1790	0.0360	1.9e-07	0.092	0.071	0.127	0.123	0.135	3.0e-11	4.8e-09	3.3e-15	9.3e-15	4.1e-16
2	GTEx	Heart Atrial Appendage	0.3640	0.0820	1.1e-04	0.082	NA	0.076	NA	0.070	1.5e-04	NA	2.7e-04	NA	4.7e-04
3	GTEx	Testis	0.3780	0.0890	5.4e-05	0.116	NA	0.228	NA	0.206	7.7e-06	NA	1.8e-10	NA	1.7e-09
4	ROSMAP	Brain Pre-frontal Cortex	0.0948	0.0310	1.3e-03	0.023	0.029	0.016	0.031	0.027	4.5e-04	1.2e-04	3.3e-03	5.7e-05	2.0e-04
5	TCGA	Lung Adenocarcinoma	0.0842	0.0324	4.1e-03	-0.002	0.019	-0.002	NA	-0.002	8.6e-01	2.3e-03	7.4e-01	NA	6.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.9	1.5	3.9	0.6	-0.5	-2.0	1.0	1.4
Bipolar Disorder or Schizophrenia	0.6	1.4	3.2	0.2	-0.7	-1.8	-0.4	1.7
Depressed Affect (Nagel 2018)	1.1	2.2	4.6	0.7	-2.0	1.4	0.0	2.1
Depression (Nagel 2018)	2.2	3.2	9.7	-0.1	-3.1	1.0	-0.7	2.3
Intelligence (Savage-Jansen 2018)	0.9	2.6	5.5	-0.9	2.3	-1.2	1.4	-1.8
Neuroticism (Nagel 2018)	0.9	2.1	7.3	0.4	-1.4	1.1	0.3	2.7
Schizophrenia (2018)	0.4	0.8	1.9	-0.2	-0.5	-0.7	-1.4	1.1
Schizophrenia vs Biploar Disorder	1.2	1.6	5.1	-0.7	-1.2	-0.0	-2.3	0.9
Worry (Nagel 2018)	0.8	1.8	4.2	-1.6	-0.5	0.4	-1.2	2.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.3	0.3	-0.5	0.4	-0.7
Alzheimer’s Disease (in father)	0.4	0.5	1.4	-0.4	0.6	-0.1	0.7	1.2
Alzheimer’s Disease (including proxy)	0.2	0.4	1.1	0.3	0.7	-0.2	1.1	0.2
Crohns Disease (2017)	0.5	1.0	3.8	-0.2	-0.8	-2.0	-0.5	0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.8	-0.1	-1.3	-0.9	0.1	-0.4
Ulcerative Colitis (UC)	0.3	0.6	1.5	-0.7	-1.2	0.0	0.3	-0.9
Major Depression (MDD)	2.0	2.4	5.9	0.2	-2.4	1.2	0.6	2.0
Reaction Time	0.4	0.9	2.7	1.2	-0.0	1.6	-0.5	0.1
Verbal and Numeric Reasoning (VNR)	1.6	3.9	8.9	-1.5	3.0	-1.4	1.4	-2.2
Breast Cancer	1.3	3.1	8.6	-1.7	2.9	-1.5	-0.6	-1.2
Ovarian Cancer	1.5	2.0	4.8	-1.4	-0.8	-2.2	-0.4	-1.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.2	1.8	4.3	-1.0	1.4	0.9	-2.1	-1.0
Bipolar Disorder (2011)	1.4	1.4	4.4	1.0	-0.2	-1.2	-0.2	2.1
Body Mass Index (BMI) (2010)	3.7	5.1	18.5	-1.1	-2.0	4.3	-1.3	0.2
Coronary Artery Disease (CAD)	0.4	0.4	1.3	-0.4	-0.3	0.4	-1.1	0.7
Crohns Disease (2012)	0.5	0.9	3.9	-0.0	-0.5	-2.0	-0.3	-0.1
Mean Putamen Volume	0.4	0.5	1.5	0.2	-0.7	-0.2	0.6	1.2
Fasting Glucose	0.7	0.8	1.9	-1.4	-0.8	-0.2	-1.3	0.2
HbA1C	0.6	0.6	1.3	-0.6	0.1	0.9	-0.8	1.2
HDL Cholesterol	1.1	1.9	6.2	0.6	0.6	-2.5	0.5	1.5
LDL Cholesterol	0.2	0.4	0.7	-0.1	0.7	0.8	0.9	0.3
Lupus	0.3	0.5	1.2	0.4	-1.1	0.3	-0.6	0.7
Neuroticism (2016)	0.6	0.9	1.9	-0.1	0.2	1.1	-1.1	1.4
Primary Biliary Cirrhosis	0.3	0.4	1.0	0.2	-1.0	0.0	0.6	0.8
Rheumatoid Arthritis	1.8	2.4	6.6	-0.0	1.9	-1.4	-2.6	-0.4
Schizophrenia (2014)	1.0	2.2	7.0	-0.6	-0.8	-1.4	-1.0	2.6
Triglycerides	0.3	0.4	0.7	-0.4	0.7	0.8	0.7	-0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.0	-0.2	-0.1	0.6	-0.8	-1.0
Ulcerative Colitis	1.1	1.6	4.3	-0.9	-1.2	-1.2	-0.1	-2.1
Blood Eosinophil Count	0.5	3.6	9.7	-2.3	1.1	-0.6	-3.1	-1.2
Blood Platelet Count	0.0	0.4	1.0	-0.3	-0.8	-0.4	-1.0	0.5
Blood Red Count	0.2	1.9	3.0	0.7	-1.7	-0.0	1.7	-1.7
Blood White Count	0.1	1.0	2.2	-0.9	0.1	0.4	-1.5	-1.3
Heel T-Score	0.1	0.9	2.9	0.5	0.7	-0.9	1.7	0.3
BMI	1.7	9.8	38.6	1.2	-2.6	6.2	-1.0	1.2
Height	0.2	3.4	13.4	0.1	3.7	-1.2	1.0	-1.1
Waist Hip Ratio (WHR)	0.1	0.4	1.3	0.2	-0.2	0.6	0.6	-1.1
Systolic Blood Pressure	0.4	2.2	9.8	-0.8	-0.5	3.1	0.0	-0.5
Smoking Status	0.2	0.4	0.7	0.1	0.9	-0.9	-0.1	0.8
Allergy or Eczema	0.1	0.2	1.1	0.2	0.0	-0.1	1.0	0.1
Cardiovascular Disease	0.6	1.9	8.8	0.1	0.8	3.0	-0.3	-0.2
Hypothyroidism (self reported)	0.5	1.2	2.2	1.1	-0.1	1.0	-1.2	1.5
Respiratory disease	0.5	1.1	2.5	-0.6	-1.6	1.2	-0.2	-1.0
Type 2 Diabetes (T2D) (2018)	0.9	1.7	6.6	-0.6	-0.7	2.6	0.3	-1.0
Lung FEV1/FVC ratio	0.4	2.1	9.7	-0.5	-0.7	3.1	0.4	-0.2
Lung FVC	0.2	1.0	2.6	1.4	-0.2	0.2	-0.3	1.6
Neuroticism	1.2	3.0	11.6	-0.1	-1.6	0.7	-0.3	3.4
Chronotype (morning person)	2.1	4.8	9.8	-2.8	-1.3	2.1	-3.1	-0.2
Hair Pigment	0.0	1.3	2.3	0.4	1.0	-1.0	1.5	1.4
Tanning	0.3	3.3	10.8	-1.1	1.1	-1.4	-1.1	-3.3
Hand grip strength (left)	0.4	1.1	1.7	1.0	1.3	1.0	1.0	1.1
Number of treatments/medications taken	1.3	2.4	9.7	-0.9	-0.8	3.1	-0.2	-0.9
Average weekly spirits intake	0.8	1.0	1.7	-1.1	-1.3	0.8	-0.1	1.3
Sensitivity / hurt feelings	1.0	1.7	3.4	1.1	0.7	-0.6	1.9	1.7
Frequency of depressed mood in last 2 weeks	0.7	0.9	3.5	-0.5	-1.9	-0.8	-0.4	0.4
Hearing difficulty/problems: Yes	2.1	3.2	6.0	-2.4	-1.8	-2.0	-1.1	-1.3
Relative age of first facial hair	0.6	1.3	3.0	-0.9	1.5	-1.7	-0.1	-0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.4	-0.4	0.8	0.7	-1.2	-0.9
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.6	-1.1	-1.9	0.4	-0.5	1.3
Ever had hysterectomy (womb removed)	1.0	1.2	2.4	1.5	1.1	-0.3	1.1	1.0
Systolic blood pressure, automated reading	1.1	3.3	12.7	-0.8	-1.7	3.6	0.3	0.2
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	4.4	-2.1	0.3	-0.6	-0.8	-2.1
Angina	0.5	0.7	1.4	0.4	1.2	0.4	1.1	-0.7
Medication for hormone replacement therapy	0.4	0.4	1.0	-0.6	0.6	-0.1	0.6	1.0
Vitamin and mineral supplements	0.8	1.1	3.8	0.7	-1.1	-0.2	-0.1	-1.9
Supplements: Zinc	0.5	0.6	1.1	-0.2	0.7	-1.0	0.3	-1.1
Medication: Co-codamol	1.5	1.7	2.7	-1.6	0.2	1.4	-1.1	-1.6
Medication: Metformin	0.5	0.7	1.5	0.7	-0.9	0.8	1.2	-0.3
Diabetes (father)	1.0	1.2	3.2	-0.6	0.1	-0.1	-1.8	-1.6
Diabetes (mother)	0.2	0.3	1.3	-0.2	-1.1	0.4	-0.2	0.1
Severe depression (siblings)	0.5	0.6	1.2	-0.3	-1.1	0.9	0.9	0.0
Pack years adult smoking proportion	0.1	0.1	0.3	0.4	-0.2	-0.4	-0.3	0.5
Impedance of leg (right)	1.1	5.3	14.0	-1.2	2.6	-3.7	-0.3	-2.0
Leg fat-free mass (left)	0.5	2.8	12.7	0.9	-0.3	3.6	0.6	0.4
Trunk fat percentage	0.5	2.0	6.2	1.2	-1.1	2.5	-0.1	-1.1
Hand grip strength (right)	0.2	0.6	1.5	-0.2	1.1	1.2	-0.3	-0.3
Townsend deprivation index at recruitment	0.8	1.1	2.3	-1.5	-1.0	-0.1	-1.3	-0.7
Current tobacco smoking	0.2	0.3	1.4	-0.1	-1.2	0.4	-0.1	0.4
Average weekly fortified wine intake	0.9	1.0	2.5	-1.3	1.6	0.4	-0.1	-0.8
Maternal smoking around birth	1.1	1.6	4.0	-1.0	-2.0	1.7	0.3	0.3
Fed-up feelings	0.6	1.0	2.3	-0.9	-1.5	0.9	0.5	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	4.1	5.5	16.0	-1.6	-4.0	1.7	-2.2	1.2
Relative age voice broke	0.7	1.1	3.5	-0.3	1.3	-1.9	-0.4	-0.2
Taking other prescription medications	0.7	1.0	4.2	0.3	-0.8	2.0	-0.5	-0.2
Age when periods started (menarche)	0.3	0.8	2.7	-0.8	0.4	0.6	-0.1	-1.6
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	4.5	0.7	-0.8	-1.6	1.2	2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.5	0.5	0.3	-1.5	1.6	-0.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.2	0.3	-1.0	0.2	1.1	1.1
Qualifications: CSEs or equivalent	0.4	0.5	1.8	1.4	-0.0	0.2	0.2	0.8
Serious illness, injury or assault to yourself	0.3	0.4	0.9	-0.1	0.9	-0.5	0.5	-0.6
High blood pressure	0.5	1.5	6.8	0.6	0.2	2.6	-0.4	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	-0.3	0.7	-0.8	1.0	-0.6
Multivitamins +/- minerals	1.1	1.4	2.4	-1.6	1.0	-0.2	1.0	1.5
Stomach or abdominal pain in last month	1.4	1.7	6.2	-0.8	-1.1	0.8	-2.5	0.1
Supplements: Glucosamine	1.2	1.5	4.2	0.5	0.5	0.9	2.1	1.5
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.9	0.2	0.6	-1.3	1.7	1.1
Medication: Atenolol	1.3	1.7	4.8	0.7	1.6	-0.0	2.2	0.6
Medication: Levothyroxine sodium	0.7	1.2	2.1	0.6	0.3	1.2	-1.4	1.4
Sitting height	0.2	1.6	6.0	-0.0	2.5	-0.6	1.4	0.1
Chronic bronchitis/emphysema (father)	2.5	2.9	4.1	1.9	-1.2	1.7	1.5	2.0
High blood pressure (mother)	0.3	0.4	1.0	0.1	-1.0	-0.2	0.2	1.0
Body mass index (BMI)	1.8	7.8	27.4	2.1	-2.5	5.2	0.3	0.8
Impedance of leg (left)	0.8	4.1	9.7	-1.0	2.6	-3.1	-0.2	-1.8
Leg predicted mass (left)	0.5	2.9	12.7	1.0	-0.3	3.6	0.7	0.4
Trunk fat mass	0.8	3.2	13.0	1.4	-0.9	3.6	0.2	-0.5
Waist circumference	1.6	6.0	22.1	2.0	-1.9	4.7	0.4	0.2
Number of incorrect matches in round	2.2	3.7	9.6	1.3	-0.3	-0.6	3.1	2.6
Past tobacco smoking	0.5	0.9	2.8	-0.7	-0.1	0.9	-0.6	-1.7
Alcohol usually taken with meals	0.4	0.7	1.7	-0.7	1.3	-0.7	0.7	-0.3
Nervous feelings	0.8	1.4	4.3	-2.1	-0.3	0.2	-1.4	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.0	-1.7	-1.7	0.7	-1.6	-0.2
Hearing difficulty/problems with background noise	1.7	2.8	4.2	-1.7	-2.0	-1.9	-1.2	1.3
Hair/balding pattern: Pattern 2	0.7	0.8	2.6	-0.6	1.6	-0.5	0.6	0.8
Had menopause	0.4	0.6	1.1	0.0	-0.7	0.9	0.6	1.1
Had other major operations	0.8	1.0	3.0	-0.2	-1.3	-0.2	1.7	-0.5
Forced vital capacity (FVC)	0.4	1.4	2.6	1.4	1.6	-0.3	1.6	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	5.4	0.8	0.6	-2.2	2.3	0.2
Ever unenthusiastic/disinterested for a whole week	1.8	2.3	9.2	0.2	-3.0	0.9	-0.8	0.8
Qualifications: None of the above	0.4	0.9	2.3	0.8	-1.5	-0.1	0.2	1.2
Financial difficulties in last 2 years	2.2	2.9	5.5	1.3	-2.2	2.3	0.9	1.2
Mouth/teeth dental problems	0.4	0.6	2.7	0.4	-0.6	-0.1	1.6	0.1
Heart attack	1.6	2.0	3.7	1.6	1.9	0.5	1.7	0.8
Allergy	0.2	0.5	1.4	0.8	0.3	0.7	-0.1	1.2
Pain all over the body in last month	0.9	0.9	2.1	0.2	-1.1	0.9	-1.4	-0.7
Diabetes (self-reported)	0.3	0.5	1.7	-0.1	-0.9	1.3	-0.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	-0.8	-0.8	-0.4	0.3	-0.4
Medication: Ramipril	0.8	1.1	2.0	-0.1	-1.0	1.3	-0.7	-1.4
Medication: Simvastatin	1.0	1.4	2.4	-1.4	1.3	1.5	-0.9	-0.1
Fluid intelligence score	1.2	2.5	5.8	-0.6	2.4	-1.3	1.0	-1.9
Illnesses of siblings	0.3	0.4	0.8	0.7	0.5	-0.9	-0.1	-0.8
Neuroticism score	1.3	2.7	7.1	-0.4	-1.9	1.5	-0.4	2.7
Weight	1.2	5.7	23.5	1.9	-0.8	4.8	0.7	0.5
Impedance of arm (right)	1.0	4.5	14.2	-1.3	0.9	-3.8	-1.6	-1.9
Arm fat percentage (right)	1.3	5.2	17.1	1.8	-2.2	4.1	-0.7	-0.1
Trunk fat-free mass	0.7	3.8	14.1	1.0	1.0	3.8	1.2	1.2
Hip circumference	1.1	4.6	16.6	2.2	-1.1	4.1	0.0	0.2
Time employed in main current job	2.2	2.6	6.5	-1.0	1.6	-1.4	-2.5	-0.9
Alcohol intake versus 10 years previously	1.6	2.4	4.7	2.1	-2.2	1.6	0.4	0.4
Father’s age at death	0.8	1.0	2.1	1.5	0.7	-0.6	1.4	0.2
Worrier / anxious feelings	0.4	0.8	1.9	-1.4	-1.0	-0.5	-0.8	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.2	-0.2	-0.8	0.1	-1.1	-1.1
Falls in the last year	0.1	0.1	0.3	0.1	0.0	-0.1	-0.6	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.1	0.8	-0.1	-0.5	0.7
Number of live births	0.4	0.6	1.5	0.2	0.7	0.7	1.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.3	1.1	1.0	0.6	1.1	-0.0
Pulse rate	0.4	0.7	2.1	-0.4	1.1	-0.1	-1.5	-0.4
Happiness	2.0	2.5	10.5	-0.0	-3.2	0.3	-1.3	0.0
Noisy workplace	2.0	2.5	4.1	2.0	-1.1	1.1	1.6	1.8
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.6	-0.4	0.8	-2.1	0.1	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.7	-1.3	-0.3	-0.1	-0.6	-0.7
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.7	-0.3	-0.3	0.0	-0.6
Asthma	0.8	1.6	2.8	-1.6	-0.5	1.2	-1.7	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.2	-1.0	-0.8	1.1	-0.2	-0.7
Medication: Cholesterol lowering	1.5	2.4	6.4	-1.5	2.5	1.5	-1.0	-0.4
Depression (self-reported)	1.9	2.2	9.4	0.1	-3.1	0.6	0.4	1.1
Medication: Lansoprazole	0.1	0.1	0.3	-0.2	0.5	0.2	-0.6	-0.2
Prospective memory result	1.0	1.2	2.9	-0.5	1.7	-0.2	-1.6	0.1
Lung cancer (father)	0.3	0.4	0.6	0.7	-0.6	0.6	0.7	-0.0
Illnesses of mother	0.8	1.0	3.2	0.6	1.8	0.4	0.0	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	3.0	0.3	1.7	0.7	0.6	0.4
Pulse wave Arterial Stiffness index	0.9	1.1	3.1	-0.7	-1.1	1.8	-0.8	-0.1
Impedance of arm (left)	1.3	6.2	20.6	-1.8	0.9	-4.5	-0.9	-2.4
Arm fat mass (right)	1.5	6.1	22.8	2.1	-1.8	4.8	0.2	0.4
Trunk predicted mass	0.6	3.7	13.5	1.0	1.1	3.7	1.2	1.2
Standing height	0.3	2.7	12.6	-0.3	3.5	-0.1	0.8	-0.4
Length of working week for main job	0.9	1.0	3.5	-0.4	-1.1	-0.3	-1.9	0.0
Exposure to tobacco smoke at home	0.8	0.9	3.2	0.6	0.0	-0.5	0.7	1.8
Breastfed as a baby	0.3	0.4	1.2	-0.3	0.0	-1.1	0.7	0.2
Tense / ‘highly strung’	0.6	1.0	2.4	-0.4	-1.6	-0.5	-1.1	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.5	-1.6	-1.4	0.7	-0.7	2.1
Hair/balding pattern: Pattern 4	0.2	0.5	1.2	0.0	-1.1	0.7	0.5	-0.5
Birth weight of first child	2.1	3.7	6.6	2.6	-1.1	0.7	2.2	2.3
Peak expiratory flow (PEF)	0.2	0.6	1.6	0.8	0.6	0.5	0.1	-1.3
Pulse wave reflection index	0.7	0.9	2.1	-1.2	-1.5	0.7	0.2	0.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.3	0.0	-1.0	1.5	-0.4	-0.1
Loud music exposure frequency	0.6	0.7	1.0	1.0	-0.2	0.8	1.0	0.9
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.8	-1.4	-0.2	-0.9	-1.0	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	0.8	1.1	0.2	-1.3	0.4
Blood clot in the leg (DVT)	1.4	1.8	5.2	-0.1	-1.6	-1.2	-2.3	-0.3
Medication: Paracetamol	1.6	2.6	5.5	-1.8	-1.6	1.1	-0.6	-2.3
Headache pain in last month	1.1	2.0	3.3	-1.8	-1.3	0.5	-1.6	-1.4
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.5	1.3	-1.1	-1.2	0.0	1.9
Glaucoma (self-reported)	0.2	0.2	0.5	-0.4	0.7	0.4	-0.3	0.3
Gout (self-reported)	0.5	0.7	1.5	1.2	0.5	0.9	-1.1	-0.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.7	1.2	0.4	1.5	-1.0	1.6
Medication: Amlodipine	0.2	0.3	0.6	-0.8	-0.3	-0.3	-0.6	-0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.5	-0.6	-0.1	0.6	-1.1	-1.2
Birth weight	0.5	1.0	2.2	-0.1	0.7	1.2	0.9	1.5
Chronic bronchitis/emphysema (mother)	1.7	1.9	4.7	-0.3	-2.2	1.9	-0.1	-1.2
High blood pressure (siblings)	0.9	1.4	4.2	-0.3	-0.4	2.1	-0.3	1.5
Forced vital capacity (FVC), Best measure	0.4	1.3	4.8	0.1	2.2	-0.0	0.8	1.1
Body fat percentage	0.7	2.7	9.5	1.3	-1.3	3.1	-0.2	-0.7
Leg fat percentage (right)	0.9	3.2	13.4	1.3	-0.9	3.7	0.0	-0.3
Arm fat-free mass (right)	0.7	3.6	13.2	1.2	0.8	3.6	1.6	0.7
Exposure to tobacco smoke outside home	0.9	1.2	4.6	2.1	0.3	-0.2	0.8	0.9
Comparative body size at age 10	0.2	0.6	1.1	0.9	-0.8	0.6	1.0	0.5
Number of full brothers	0.1	0.2	0.6	-0.3	0.1	-0.2	0.8	-0.3
Worry too long after embarrassment	0.5	0.9	1.8	0.7	-1.3	-0.3	0.3	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.4	-0.2	0.4	0.1	0.6	1.2
Wheeze or whistling in the chest in last year	0.6	1.0	2.1	-0.8	-1.4	1.4	0.3	-0.3
Number of children fathered	0.4	0.5	1.0	-0.6	1.0	0.9	0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.8	1.0	1.3	-0.0	1.4	0.8
Age at first live birth	1.0	1.7	4.8	2.2	1.0	-1.0	1.2	0.1
Pulse wave peak to peak time	0.9	1.1	3.0	0.6	1.3	-1.7	0.6	0.1
Health satisfaction	1.3	1.6	3.8	-1.0	-2.0	1.0	-1.5	-0.2
Shortness of breath walking on level ground	2.2	2.7	7.2	-0.8	-1.8	0.7	-2.7	1.4
Qualifications: College or University degree	0.5	1.4	3.6	-1.5	0.7	-1.9	0.2	-0.8
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.4	0.3	0.5	0.2	0.4
Mouth/teeth dental problems: Loose teeth	2.5	3.0	7.6	0.8	-1.8	2.7	-1.2	1.4
Emphysema/chronic bronchitis	1.7	2.0	5.1	-1.0	-2.3	0.5	-1.6	-0.9
Medication for pain relief, constipation, heartburn	2.0	3.5	7.9	1.8	0.3	-2.4	0.7	2.8
Neck or shoulder pain in last month	1.3	1.8	5.9	-1.2	-1.0	2.4	-1.0	0.2
Medication: Blood pressure	0.9	1.6	5.8	-1.3	0.5	0.5	-0.2	-2.4
Angina (self-reported)	0.7	1.0	2.0	0.4	1.4	0.2	1.4	-0.8
Migraine (self-reported)	0.2	0.3	0.9	0.5	-0.9	0.3	-0.2	0.1
Medication: Ibuprofen	0.4	0.5	1.3	-0.5	-0.4	1.1	0.4	-0.9
Medication: Allopurinol	0.2	0.3	0.6	0.7	0.8	0.4	-0.1	0.3
Medication: Omeprazole	0.3	0.4	0.7	-0.8	0.3	0.4	0.6	-0.7
Medication: Seretide 50 evohaler	1.2	1.4	4.0	-0.4	-0.1	2.0	-1.7	-0.3
Mean time to correctly identify matches	0.2	0.4	1.5	-0.1	-0.1	1.2	-0.7	0.2
Heart disease (mother)	0.6	0.7	1.6	-0.4	-1.3	-0.0	-1.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	4.5	1.7	-2.1	0.6	0.7	1.3
Whole body fat mass	1.0	4.1	16.7	1.6	-1.0	4.1	0.4	-0.1
Leg fat mass (right)	1.2	4.7	20.2	1.6	-0.8	4.5	0.3	0.1
Arm predicted mass (right)	0.8	4.2	14.4	1.3	0.8	3.8	1.9	0.9
Pulse rate, automated reading	0.1	0.4	1.8	-0.2	1.4	0.5	-0.0	-0.2
Alcohol intake frequency.	1.0	2.2	5.1	0.8	-2.3	1.7	0.4	-1.6
Comparative height size at age 10	0.3	1.5	6.8	-0.9	2.6	0.0	0.4	0.0
Number of full sisters	0.9	1.1	2.6	0.9	-1.0	1.6	-0.2	0.9
Suffer from ‘nerves’	1.9	3.0	7.0	-2.0	-1.3	0.5	-2.6	1.5
Overall health rating	1.4	3.1	9.8	0.7	-1.2	3.1	-1.9	-0.3
Chest pain or discomfort	1.0	1.4	4.2	-0.2	-1.6	0.1	-2.1	-0.0
Had major operations	0.6	0.7	3.2	-0.0	1.8	-0.4	-0.0	0.1
Age at last live birth	1.2	1.8	4.2	1.8	-0.0	-0.7	2.0	1.1
Family relationship satisfaction	2.3	2.8	8.2	-0.6	-2.9	0.2	-1.7	1.6
Leg pain on walking	0.9	1.2	4.2	0.5	-0.7	0.8	2.1	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	-0.3	0.5	1.0	0.4	-1.2
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.4	1.0	1.1	-0.1	1.2	-1.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.3	1.1	1.0	-1.5	-0.5	-0.8
Medication: Aspirin	1.0	1.3	3.2	-1.0	1.0	0.8	-0.8	-1.8
Supplements: Vitamin C	1.0	1.2	2.3	-1.0	1.5	-1.0	-0.7	1.0
Knee pain experienced in last month	1.8	2.7	8.4	-0.7	-1.3	2.9	0.4	1.7
Hypertension (Self-reported)	0.4	1.1	4.4	0.2	0.9	2.1	-0.3	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.2	-0.7	1.1	-0.0	-1.5	0.1
Illnesses of father: Heart disease	0.4	0.6	2.7	0.2	-0.3	-0.2	-1.6	-0.3
Illnesses of siblings: Diabetes	0.8	1.0	2.3	-1.0	-1.0	1.5	-0.5	-0.7
Smoking status: Previous	0.8	1.2	2.9	0.4	1.0	-1.4	-0.0	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	4.3	0.6	2.1	0.5	0.0	0.6
Whole body fat-free mass	0.6	3.6	15.1	0.9	0.5	3.9	0.9	1.0
Leg fat-free mass (right)	0.6	3.2	13.5	1.1	-0.4	3.7	0.8	0.7
Arm fat percentage (left)	1.1	4.4	13.8	1.7	-2.2	3.7	-0.4	-0.1
Average weekly red wine intake	1.5	2.3	5.9	0.6	0.6	-1.9	2.4	1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	0.6	-0.2	1.0	-0.6	1.1
Mood swings	0.9	1.7	5.4	-0.4	-2.3	0.2	-0.0	1.7
Loneliness, isolation	3.0	4.1	8.5	-0.5	-2.9	1.2	-2.8	1.5
Long-standing illness, disability or infirmity	1.0	1.5	3.6	-0.9	-0.7	1.4	-1.9	-0.6
Ever had bowel cancer screening	1.0	1.2	2.7	0.4	-1.2	0.6	1.6	1.1
Diabetes diagnosed by doctor	0.6	0.9	3.5	-0.6	-0.6	1.9	-0.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.8	0.7	-1.4	0.1	-0.0	-0.3
Friendships satisfaction	1.0	1.2	4.3	-0.6	-2.1	1.1	0.3	-0.3
Qualifications: nursing, teaching	0.8	1.2	4.8	-0.5	-0.1	-0.8	2.2	-0.6
Commuting to job workplace: Walk	0.6	0.6	1.8	-0.5	0.4	-1.3	-0.6	0.8
Eye problems/disorders: Cataract	0.6	0.7	1.7	0.6	-1.1	0.3	-0.4	1.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.3	-1.1	-0.7	-0.6	-1.0	-1.1
Medication for cholesterol	0.7	1.1	2.2	0.8	-0.4	-1.4	0.7	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.8	-2.0	-0.4	0.2	-1.4	-0.1
Back pain experienced in last month	0.8	1.1	1.7	-1.2	-0.4	1.1	-1.0	-1.3
Mineral and other dietary supplements	1.3	1.7	7.0	-0.2	1.2	-0.1	-2.6	-0.4
Breast cancer (self-reported)	0.3	0.4	1.2	1.1	-0.1	0.1	0.7	0.3
Asthma (self-reported)	0.9	1.8	3.0	-1.7	-0.7	1.4	-1.4	-1.2
Osteoporosis (self-reported)	1.6	2.0	3.6	1.9	-0.8	-1.4	0.8	1.8
Osteoarthritis (self-reported)	0.7	0.9	2.6	0.8	-0.2	-0.1	1.0	-1.6
Medication: Aspirin	1.3	1.7	4.4	-1.2	1.4	0.5	-0.5	-2.1
Medication: Gliclazide	0.6	0.7	1.6	1.0	-1.2	-0.8	-0.0	-0.2
Illnesses of father: None of the above (group 1)	0.6	0.7	2.6	-1.6	-0.3	-0.8	-0.6	-0.1
Smoking status: Current	0.2	0.4	1.2	0.4	-1.1	0.6	0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.0	0.8	-0.6	0.2	0.2
Whole body water mass	0.7	3.8	15.5	1.1	0.5	3.9	1.0	1.0
Leg predicted mass (right)	0.6	3.2	13.4	1.1	-0.4	3.7	0.8	0.7
Arm fat mass (left)	1.4	5.8	20.5	2.3	-1.8	4.5	0.4	0.3
Number of self-reported non-cancer illnesses	1.4	2.5	6.0	0.0	-1.4	2.4	-2.0	0.2
Average weekly champagne plus white wine intake	0.5	0.6	1.6	-0.6	-0.4	-0.9	0.4	1.2
Miserableness	1.1	1.9	3.9	0.6	-2.0	0.8	1.4	1.6
Guilty feelings	0.8	1.2	3.0	0.6	-1.7	0.7	0.4	1.5
Wears glasses or contact lenses	1.5	1.8	3.8	-0.8	1.4	-2.0	1.3	1.0
Ever taken oral contraceptive pill	1.0	1.1	4.8	0.5	-2.2	0.0	0.7	-0.1
Hearing aid user	0.2	0.3	0.8	-0.1	0.2	-0.6	-0.9	-0.4
Mother’s age at death	0.4	0.5	1.2	-0.1	1.1	-1.0	-0.4	-0.1
Financial situation satisfaction	1.5	1.8	3.8	2.0	-1.3	0.6	1.1	1.4
Tinnitus: Yes, now most or all of the time	1.3	1.5	6.4	0.8	0.7	-0.3	-0.2	2.5
Commuting to job workplace: Public transport	1.3	1.5	4.6	-0.1	-1.6	0.2	-0.7	2.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	-0.3	0.3	0.3	-0.1	0.6
Medication: Blood pressure	0.5	0.9	3.0	0.5	0.1	1.7	-0.2	1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.3	-0.1	-0.3	1.1	-0.2	-0.6
Supplements: Fish oil (including cod liver oil)	1.1	1.5	5.0	0.1	-1.5	0.2	2.2	0.3
High cholesterol (Self-reported)	1.2	2.1	5.2	-1.4	1.0	2.3	-1.3	-0.8
Medication: Bendroflumethiazide	1.1	1.7	6.0	0.9	2.5	0.3	0.9	0.9
Medication: Paracetamol	1.1	1.7	4.6	-1.1	-0.9	1.2	0.5	-2.2
Medication: Lisinopril	0.5	0.7	1.1	0.8	1.1	0.9	-0.2	1.0
Medication: Atorvastatin	0.8	1.0	2.5	-1.0	-0.5	1.6	-1.0	-0.1
Illnesses of father: High blood pressure	0.5	0.6	1.0	0.3	0.0	1.0	-0.9	1.0
Alcohol drinker status: Never	1.1	1.3	3.9	0.4	1.2	-0.6	0.6	-2.0
Ever smoked	0.5	0.8	2.4	1.0	-0.1	-0.6	0.5	1.5
Basal metabolic rate	0.8	4.3	18.1	1.3	0.2	4.3	1.0	0.7
Leg fat percentage (left)	1.1	4.2	17.6	1.3	-1.2	4.2	0.2	-0.2
Arm fat-free mass (left)	1.0	4.9	20.7	1.3	0.5	4.5	1.2	0.8
Number of operations (self-reported)	0.5	0.8	1.8	-0.7	1.3	-1.3	-0.2	-0.0
Average weekly beer plus cider intake	0.9	1.3	2.5	0.8	-1.4	1.6	-1.0	0.5
Irritability	0.6	1.0	2.8	0.6	0.2	1.4	-0.2	1.7
Risk taking	1.8	2.7	6.8	2.1	-0.2	1.2	0.8	2.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.0	0.1	1.4	-0.7	0.6	0.0
Fractured/broken bones in last 5 years	0.2	0.2	0.5	-0.4	0.5	0.7	0.1	-0.3
Age started oral contraceptive pill	0.2	0.3	0.7	-0.6	0.8	0.2	0.4	-0.3
Diastolic blood pressure, automated reading	0.7	2.1	8.0	-0.2	-1.3	2.8	0.4	0.7
Ever depressed for a whole week	1.6	2.0	8.3	0.2	-2.9	1.0	-0.2	0.8
Unable to work because of sickness or disability	1.0	1.3	2.2	-1.5	-0.8	1.3	-0.8	-1.2
Commuting to job workplace: Cycle	0.9	1.1	2.3	-0.3	1.2	-1.3	-0.1	-1.5
Myopia	0.2	0.3	1.0	-0.0	-0.2	0.1	0.5	1.0
Vascular/heart problems diagnosed by doctor	0.5	1.3	5.0	-1.0	-0.3	-2.2	-0.4	-0.3
Cholesterol lowering medication	0.6	0.9	1.7	-1.1	0.7	1.1	-1.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.7	-0.1	0.6	0.6	0.4
Pain experienced in last month	1.8	2.9	4.5	1.9	1.9	-1.6	2.1	0.5
Supplements: Calcium	0.9	1.0	2.5	-0.6	-0.5	0.4	1.6	1.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.8	1.3	-0.2	-0.1	0.8	0.1
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.6	1.4	2.1	0.4	1.4	0.7
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	5.4	-0.1	-1.7	-1.4	-2.3	-0.3
Heart disease (siblings)	0.2	0.2	0.8	-0.4	-0.9	0.2	0.3	0.3
Alcohol drinker status: Previous	0.6	0.6	1.6	-0.0	-1.2	1.3	0.4	-0.1
Pack years of smoking	0.2	0.2	1.0	0.4	-0.1	-0.3	0.1	1.0
Impedance of whole body	1.4	7.0	21.2	-1.4	2.2	-4.6	-0.8	-2.5
Leg fat mass (left)	1.3	5.3	22.8	1.4	-1.1	4.8	0.5	0.2
Arm predicted mass (left)	1.0	5.3	21.0	1.6	0.7	4.6	1.4	0.8