Hub : Genes

PARP3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.129 0.0679 0.0087 0.079 NA 0.082 NA 0.078 3.0e-06 NA 2.0e-06 NA 3.5e-06
2 GTEx Pituitary 0.460 0.1400 0.0064 0.145 NA 0.068 NA 0.113 1.8e-04 NA 8.8e-03 NA 9.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.6 0.9 1.7 0.4 1.3
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 -0.1 0.4
Depressed Affect (Nagel 2018) 2.0 4.2 8.0 -2.8 -0.7
Depression (Nagel 2018) 1.7 2.5 4.8 -2.2 0.5
Intelligence (Savage-Jansen 2018) 0.8 2.5 5.0 2.2 0.3
Neuroticism (Nagel 2018) 1.5 3.5 6.1 -2.5 -0.9
Schizophrenia (2018) 0.1 0.2 0.3 -0.5 -0.5
Schizophrenia vs Biploar Disorder 1.3 1.7 2.1 1.4 -1.1
Worry (Nagel 2018) 0.7 1.5 2.6 -1.6 -0.6
Alzheimer’s Disease (in mother) 0.2 0.3 0.4 -0.4 0.6
Alzheimer’s Disease (in father) 0.1 0.1 0.1 0.2 0.3
Alzheimer’s Disease (including proxy) 0.3 0.4 0.5 -0.7 0.6
Crohns Disease (2017) 0.2 0.5 0.7 -0.8 -0.5
Irritable Bowel Disease (IBD) 0.1 0.3 0.5 -0.3 0.7
Ulcerative Colitis (UC) 0.6 1.2 2.3 -0.1 1.5
Major Depression (MDD) 1.2 1.4 2.3 0.7 -1.5
Reaction Time 2.0 3.8 6.2 -1.2 2.5
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.5 1.6 0.2
Breast Cancer 0.3 0.8 1.6 -0.3 1.2
Ovarian Cancer 0.3 0.4 0.8 -0.9 0.2
Prostate Cancer 0.3 0.5 1.0 -0.1 -1.0
Age at First Birth 1.2 1.7 2.6 0.9 -1.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.4 3.2 3.7 -1.7 1.9
Coronary Artery Disease (CAD) 0.3 0.3 0.5 -0.7 0.4
Crohns Disease (2012) 0.0 0.0 0.0 -0.1 -0.2
Mean Putamen Volume 1.3 1.4 2.5 1.6 -0.6
Fasting Glucose 0.3 0.3 0.6 -0.8 0.2
HbA1C 0.1 0.1 0.2 0.4 0.2
HDL Cholesterol 0.0 0.1 0.1 -0.4 -0.1
LDL Cholesterol 1.6 2.6 3.4 -1.3 1.9
Lupus 0.3 0.5 1.0 -0.1 -1.0
Neuroticism (2016) 1.2 1.8 3.5 -0.0 -1.9
Primary Biliary Cirrhosis 0.8 1.2 2.3 -0.2 1.5
Rheumatoid Arthritis 1.0 1.4 2.0 1.0 1.4
Schizophrenia (2014) 0.1 0.2 0.4 -0.6 -0.1
Triglycerides 0.2 0.3 0.3 -0.5 0.5
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.1 0.4 0.0
Ulcerative Colitis 0.8 1.2 2.0 0.6 1.4
Blood Eosinophil Count 0.0 0.3 0.4 -0.6 -0.5
Blood Platelet Count 0.0 0.3 0.6 -0.1 0.8
Blood Red Count 0.2 1.9 3.8 0.3 -1.9
Blood White Count 0.2 1.5 3.0 -0.2 -1.7
Heel T-Score 0.9 6.8 12.3 -1.2 -3.5
BMI 2.0 11.4 21.9 -0.9 4.7
Height 2.2 41.9 80.1 1.9 -8.9
Waist Hip Ratio (WHR) 0.2 0.8 0.9 -0.9 -0.9
Systolic Blood Pressure 0.7 3.7 6.2 -1.1 -2.5
Smoking Status 3.0 7.1 11.0 -3.3 1.8
Allergy or Eczema 1.4 3.6 5.3 2.3 -1.4
Cardiovascular Disease 0.1 0.3 0.6 -0.8 0.0
Hypothyroidism (self reported) 0.1 0.3 0.5 0.4 0.7
Respiratory disease 0.7 1.5 2.5 -1.6 0.7
Type 2 Diabetes (T2D) (2018) 0.1 0.3 0.4 -0.6 0.3
Lung FEV1/FVC ratio 0.5 2.6 4.6 -0.8 2.1
Lung FVC 0.5 2.6 4.3 0.9 2.1
Neuroticism 0.8 1.9 3.0 -1.7 -0.9
Chronotype (morning person) 1.2 2.7 4.9 -2.2 0.7
Hair Pigment 0.0 1.3 1.5 -1.0 1.2
Tanning 0.2 2.2 4.4 -0.2 -2.1
Hand grip strength (left) 2.9 7.5 14.4 0.8 -3.8
Number of treatments/medications taken 0.8 1.4 1.9 -1.4 0.9
Average weekly spirits intake 0.3 0.4 0.5 -0.7 -0.5
Sensitivity / hurt feelings 0.5 0.9 1.8 -1.4 -0.0
Frequency of depressed mood in last 2 weeks 0.5 0.7 0.7 -0.9 0.8
Hearing difficulty/problems: Yes 0.7 1.1 2.1 -0.4 1.5
Relative age of first facial hair 1.3 2.6 3.8 1.2 -1.9
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.6 -0.0 0.8
Ever used hormone-replacement therapy (HRT) 2.6 3.3 5.1 -1.2 2.3
Ever had hysterectomy (womb removed) 1.8 2.0 3.1 -1.8 1.0
Systolic blood pressure, automated reading 0.5 1.6 1.9 -1.4 -1.1
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 2.6 1.6 1.4
Angina 0.3 0.4 0.7 0.3 0.8
Medication for hormone replacement therapy 1.0 1.1 2.1 -0.1 -1.5
Vitamin and mineral supplements 0.1 0.1 0.2 -0.4 -0.2
Supplements: Zinc 0.9 0.9 1.0 1.0 1.0
Medication: Co-codamol 1.0 1.1 2.2 -1.5 0.4
Medication: Metformin 1.1 1.5 2.0 1.4 1.0
Diabetes (father) 0.1 0.1 0.2 -0.4 0.2
Diabetes (mother) 0.1 0.1 0.1 0.1 0.4
Severe depression (siblings) 0.1 0.2 0.2 -0.3 0.5
Pack years adult smoking proportion 0.3 0.5 0.6 -0.5 0.8
Impedance of leg (right) 3.5 16.9 31.1 -1.7 -5.6
Leg fat-free mass (left) 0.2 1.0 2.0 1.4 0.2
Trunk fat percentage 0.3 1.3 2.5 -1.6 0.2
Hand grip strength (right) 4.2 11.3 20.6 1.5 -4.5
Townsend deprivation index at recruitment 0.5 0.7 1.0 -1.0 -0.7
Current tobacco smoking 0.2 0.4 0.6 -0.4 0.8
Average weekly fortified wine intake 2.5 3.0 4.4 1.2 -2.1
Maternal smoking around birth 0.2 0.2 0.4 -0.3 0.6
Fed-up feelings 1.2 2.3 3.8 -0.9 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.2 -0.3 -1.1
Relative age voice broke 0.9 1.3 2.0 0.8 -1.4
Taking other prescription medications 0.8 1.2 1.5 -1.2 -1.0
Age when periods started (menarche) 4.2 10.0 14.7 2.3 -3.8
Bilateral oophorectomy (both ovaries removed) 5.4 6.2 10.4 -3.2 1.4
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.4 3.9 -2.0 -1.7
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.4 0.5 -1.2
Qualifications: CSEs or equivalent 0.2 0.3 0.3 -0.6 -0.5
Serious illness, injury or assault to yourself 0.6 0.7 0.8 -0.8 -0.9
High blood pressure 0.3 0.7 1.4 0.0 1.2
Hayfever, allergic rhinitis or eczema 2.6 5.6 9.8 1.2 -3.1
Multivitamins +/- minerals 0.2 0.3 0.5 0.7 -0.4
Stomach or abdominal pain in last month 0.9 1.1 1.6 -0.7 -1.3
Supplements: Glucosamine 0.4 0.6 1.0 -0.3 -1.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.2 0.4 0.5
Medication: Atenolol 1.9 2.4 4.0 -0.9 2.0
Medication: Levothyroxine sodium 2.8 4.7 6.6 1.7 2.6
Sitting height 1.7 11.8 21.2 1.6 -4.6
Chronic bronchitis/emphysema (father) 0.3 0.4 0.5 -0.7 0.5
High blood pressure (mother) 1.9 2.6 4.6 -2.1 0.8
Body mass index (BMI) 2.2 9.5 18.7 -0.5 4.3
Impedance of leg (left) 3.5 17.1 32.4 -1.4 -5.7
Leg predicted mass (left) 0.2 1.1 2.1 1.5 0.2
Trunk fat mass 0.1 0.3 0.6 -0.8 0.2
Waist circumference 1.0 3.5 6.7 -0.7 2.6
Number of incorrect matches in round 0.9 1.4 1.5 -1.2 1.2
Past tobacco smoking 3.6 6.6 10.0 3.2 -1.8
Alcohol usually taken with meals 0.2 0.4 0.7 0.2 -0.8
Nervous feelings 0.0 0.0 0.0 -0.1 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 2.7 0.5 -1.6
Hearing difficulty/problems with background noise 1.0 1.6 3.0 -1.7 0.5
Hair/balding pattern: Pattern 2 0.1 0.1 0.1 0.4 0.3
Had menopause 5.0 6.2 12.2 -0.5 3.5
Had other major operations 3.9 4.7 9.3 -3.0 -0.5
Forced vital capacity (FVC) 0.7 2.9 4.0 1.3 -2.0
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 3.1 -1.5 -1.8
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.5 -0.6 0.7
Qualifications: None of the above 1.3 2.9 5.2 -0.7 2.3
Financial difficulties in last 2 years 0.2 0.3 0.6 0.8 0.2
Mouth/teeth dental problems 0.2 0.2 0.5 -0.0 -0.7
Heart attack 0.9 1.2 2.0 -1.4 -0.6
Allergy 0.5 1.2 2.2 0.5 1.5
Pain all over the body in last month 0.9 1.0 1.5 -0.7 1.2
Diabetes (self-reported) 0.3 0.4 0.7 0.8 0.4
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 5.7 0.2 -2.4
Medication: Ramipril 1.7 2.1 4.2 -0.4 2.0
Medication: Simvastatin 0.5 0.8 1.5 -0.1 1.2
Fluid intelligence score 1.2 2.5 3.6 1.9 -1.2
Illnesses of siblings 0.1 0.1 0.2 -0.1 -0.4
Neuroticism score 0.7 1.4 1.8 -1.3 -1.0
Weight 0.1 0.5 0.7 0.6 0.9
Impedance of arm (right) 2.6 12.4 21.7 -1.7 -4.7
Arm fat percentage (right) 1.5 6.1 8.7 -1.9 2.9
Trunk fat-free mass 0.5 2.6 5.2 2.3 -0.2
Hip circumference 0.4 1.6 3.0 0.5 1.7
Time employed in main current job 4.8 5.5 7.0 -2.7 2.0
Alcohol intake versus 10 years previously 0.3 0.4 0.7 0.8 0.3
Father’s age at death 0.6 0.8 1.6 1.3 -0.0
Worrier / anxious feelings 0.6 1.1 1.4 -0.9 -1.2
Frequency of tiredness / lethargy in last 2 weeks 3.1 5.0 8.1 -2.8 -1.4
Falls in the last year 0.9 1.2 1.3 -1.1 1.1
Hair/balding pattern: Pattern 3 2.6 3.8 6.8 -2.6 -0.9
Number of live births 3.5 4.9 6.3 -1.9 2.5
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 2.9 1.3 -1.7
Pulse rate 0.1 0.2 0.3 -0.2 0.6
Happiness 0.5 0.6 0.9 0.9 -0.5
Noisy workplace 1.0 1.3 2.5 -0.2 1.6
Qualifications: A levels/AS levels or equivalent 0.6 1.3 2.5 1.6 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 -0.3 -0.3
Mouth/teeth dental problems: Dentures 1.1 1.9 3.8 0.1 1.9
Asthma 1.3 2.6 4.3 -2.1 1.0
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 3.2 -1.8 0.1
Medication: Cholesterol lowering 0.3 0.5 1.0 -0.2 1.0
Depression (self-reported) 0.6 0.8 1.3 -1.2 -0.4
Medication: Lansoprazole 0.2 0.2 0.4 0.4 0.6
Prospective memory result 1.5 1.9 3.0 -1.7 -0.8
Lung cancer (father) 0.1 0.2 0.3 0.6 0.1
Illnesses of mother 0.1 0.2 0.2 0.5 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 1.3 1.0 -1.2
Pulse wave Arterial Stiffness index 0.0 0.0 0.0 0.1 -0.1
Impedance of arm (left) 3.1 14.5 25.4 -1.9 -5.0
Arm fat mass (right) 0.6 2.6 4.9 -0.6 2.2
Trunk predicted mass 0.5 2.8 5.6 2.4 -0.2
Standing height 2.6 25.8 47.6 2.0 -6.9
Length of working week for main job 2.0 2.2 2.9 -1.2 -1.7
Exposure to tobacco smoke at home 1.7 1.9 2.6 -1.6 1.1
Breastfed as a baby 1.0 1.2 1.9 1.4 0.8
Tense / ‘highly strung’ 3.0 5.0 9.1 -1.0 -3.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.4 -0.7 -0.4
Hair/balding pattern: Pattern 4 0.2 0.4 0.7 0.2 -0.9
Birth weight of first child 0.4 0.7 0.7 -0.8 0.8
Peak expiratory flow (PEF) 1.9 4.4 4.9 2.2 -2.0
Pulse wave reflection index 0.9 1.2 2.1 1.4 0.5
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.3 -0.6 0.3
Loud music exposure frequency 1.0 1.1 2.2 1.5 0.2
Qualifications: O levels/GCSEs or equivalent 1.8 2.9 4.2 2.1 -1.2
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.0 -0.0 -0.2
Blood clot in the leg (DVT) 1.1 1.4 1.9 -1.4 1.0
Medication: Paracetamol 1.2 2.1 3.9 -0.5 2.0
Headache pain in last month 0.6 1.0 1.9 -1.4 0.2
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.6 0.0 -0.8
Glaucoma (self-reported) 0.1 0.1 0.1 -0.0 0.3
Gout (self-reported) 0.5 0.7 0.8 0.9 -0.7
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 2.7 1.6 1.6
Medication: Amlodipine 1.8 2.6 4.3 0.9 2.1
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.8 -0.5 0.9
Birth weight 0.5 1.1 1.6 1.3 -0.7
Chronic bronchitis/emphysema (mother) 0.0 0.1 0.1 -0.1 0.3
High blood pressure (siblings) 0.4 0.5 1.1 -0.1 1.0
Forced vital capacity (FVC), Best measure 0.5 1.9 2.9 1.0 -1.7
Body fat percentage 0.5 2.2 3.4 -1.8 1.0
Leg fat percentage (right) 1.1 4.1 4.2 -2.0 2.0
Arm fat-free mass (right) 0.3 1.7 3.0 1.7 -0.5
Exposure to tobacco smoke outside home 0.8 1.1 1.5 -1.2 0.9
Comparative body size at age 10 2.4 6.6 12.8 -0.6 3.6
Number of full brothers 3.8 4.7 5.3 -2.0 2.3
Worry too long after embarrassment 0.6 1.0 1.0 -1.0 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.2 2.9 4.5 -2.1 -1.2
Wheeze or whistling in the chest in last year 1.0 1.8 2.9 -1.7 -0.8
Number of children fathered 0.7 0.8 1.2 -1.1 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.8 -0.9 -0.4
Age at first live birth 2.1 3.7 7.3 2.7 -0.4
Pulse wave peak to peak time 0.1 0.1 0.2 0.1 -0.4
Health satisfaction 1.3 1.7 3.4 -0.2 -1.8
Shortness of breath walking on level ground 0.2 0.2 0.4 -0.6 -0.1
Qualifications: College or University degree 0.3 0.9 1.8 0.0 -1.3
Eye problems/disorders: None of the above 0.6 0.7 1.4 -0.2 -1.2
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.8 0.4 -1.3
Emphysema/chronic bronchitis 0.7 0.8 1.4 1.2 0.3
Medication for pain relief, constipation, heartburn 1.5 2.5 3.1 1.4 -1.8
Neck or shoulder pain in last month 0.4 0.6 0.7 0.9 -0.7
Medication: Blood pressure 0.4 0.6 0.8 0.7 0.9
Angina (self-reported) 0.2 0.2 0.4 0.3 0.7
Migraine (self-reported) 1.2 1.6 2.1 1.4 -1.0
Medication: Ibuprofen 1.2 1.5 2.9 -1.7 -0.2
Medication: Allopurinol 0.1 0.1 0.2 0.4 -0.1
Medication: Omeprazole 1.9 2.3 2.7 -1.4 1.6
Medication: Seretide 50 evohaler 0.3 0.3 0.6 -0.0 0.8
Mean time to correctly identify matches 2.0 3.9 6.3 -1.2 2.5
Heart disease (mother) 0.4 0.5 0.8 -0.4 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.4 -0.1 1.2
Whole body fat mass 0.1 0.5 0.7 -0.6 0.8
Leg fat mass (right) 0.5 1.8 2.6 -1.0 1.6
Arm predicted mass (right) 0.4 1.9 3.6 1.9 -0.4
Pulse rate, automated reading 0.7 2.3 4.5 -0.3 -2.1
Alcohol intake frequency. 0.2 0.5 0.6 0.5 0.8
Comparative height size at age 10 0.7 4.1 7.6 0.7 -2.8
Number of full sisters 1.0 1.3 2.5 -0.2 1.6
Suffer from ‘nerves’ 0.5 0.7 1.4 -0.1 1.2
Overall health rating 1.0 2.1 4.0 -2.0 -0.5
Chest pain or discomfort 1.3 1.9 2.5 -1.1 -1.6
Had major operations 0.7 0.9 1.1 0.8 1.0
Age at last live birth 0.9 1.3 2.3 1.5 0.5
Family relationship satisfaction 1.9 2.4 4.6 0.4 -2.1
Leg pain on walking 1.8 2.2 3.9 0.7 -2.0
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 -0.5 -0.0
Commuting to job workplace: Car/motor vehicle 0.1 0.2 0.2 0.4 0.4
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.0 0.0 -0.1
Medication: Aspirin 0.7 0.9 1.8 -0.1 1.4
Supplements: Vitamin C 0.1 0.1 0.2 -0.0 0.4
Knee pain experienced in last month 0.3 0.4 0.4 0.7 -0.6
Hypertension (Self-reported) 0.5 1.4 2.7 -0.4 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.1 0.1 0.1 -0.3
Illnesses of father: Heart disease 0.2 0.3 0.4 0.4 0.6
Illnesses of siblings: Diabetes 0.2 0.2 0.5 0.1 0.7
Smoking status: Previous 5.3 7.9 13.2 -3.6 1.6
Forced expiratory volume in 1-second (FEV1), predicted 3.4 7.0 10.5 1.9 -3.2
Whole body fat-free mass 0.4 2.1 4.3 2.1 -0.1
Leg fat-free mass (right) 0.3 1.5 3.0 1.7 0.2
Arm fat percentage (left) 1.3 5.0 6.7 -1.8 2.6
Average weekly red wine intake 0.7 1.1 2.2 -0.2 -1.5
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.5 0.4 0.7
Mood swings 1.0 1.7 2.4 -1.0 -1.5
Loneliness, isolation 0.3 0.4 0.5 -0.7 0.6
Long-standing illness, disability or infirmity 2.0 3.0 4.8 -2.2 1.1
Ever had bowel cancer screening 0.4 0.4 0.8 0.2 -0.9
Diabetes diagnosed by doctor 0.6 1.0 1.1 1.0 1.0
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.1 0.4 1.4
Friendships satisfaction 0.2 0.3 0.6 0.2 -0.8
Qualifications: nursing, teaching 0.0 0.1 0.1 -0.3 0.1
Commuting to job workplace: Walk 0.0 0.0 0.0 -0.0 0.1
Eye problems/disorders: Cataract 0.9 1.0 2.1 0.1 1.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.7 -0.3 -0.8
Medication for cholesterol 0.4 0.6 0.7 -0.7 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.4 0.3 -0.6
Back pain experienced in last month 1.8 2.6 4.5 -0.9 -2.1
Mineral and other dietary supplements 1.0 1.3 1.7 1.3 1.0
Breast cancer (self-reported) 0.5 0.6 1.0 -1.0 -0.5
Asthma (self-reported) 1.7 3.4 5.8 -2.4 1.1
Osteoporosis (self-reported) 1.0 1.2 2.2 -0.5 -1.5
Osteoarthritis (self-reported) 2.6 3.4 4.8 -2.2 1.4
Medication: Aspirin 0.7 0.9 1.8 -0.2 1.4
Medication: Gliclazide 0.4 0.5 0.6 -0.6 0.8
Illnesses of father: None of the above (group 1) 0.2 0.3 0.5 -0.7 -0.2
Smoking status: Current 0.3 0.4 0.7 -0.4 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.1 -0.3 -0.2
Whole body water mass 0.3 1.9 3.8 1.9 -0.0
Leg predicted mass (right) 0.3 1.4 2.7 1.6 0.2
Arm fat mass (left) 0.7 3.0 4.9 -1.0 2.2
Number of self-reported non-cancer illnesses 0.9 1.6 2.1 -1.5 1.0
Average weekly champagne plus white wine intake 0.4 0.5 0.8 -0.4 -0.9
Miserableness 0.6 1.1 1.3 -0.9 -1.1
Guilty feelings 0.4 0.6 1.0 1.0 -0.4
Wears glasses or contact lenses 0.1 0.1 0.2 -0.1 0.4
Ever taken oral contraceptive pill 1.8 2.0 4.0 -2.0 -0.3
Hearing aid user 0.2 0.2 0.3 -0.5 0.3
Mother’s age at death 2.2 2.8 3.9 1.3 2.0
Financial situation satisfaction 0.8 1.0 1.9 0.1 -1.4
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 0.5 -0.1
Commuting to job workplace: Public transport 1.2 1.4 2.2 -1.5 0.8
Eye problems/disorders: Glaucoma 0.3 0.4 0.7 0.9 0.3
Medication: Blood pressure 1.2 2.3 3.8 0.9 2.0
Pain type(s) experienced in last month: Hip pain 2.2 2.8 4.0 -2.0 -1.2
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.4 -0.1 -0.6
High cholesterol (Self-reported) 0.6 1.1 1.3 0.9 1.2
Medication: Bendroflumethiazide 0.9 1.3 2.2 0.7 1.5
Medication: Paracetamol 0.7 1.1 1.7 -0.8 1.3
Medication: Lisinopril 0.3 0.4 0.8 0.9 -0.1
Medication: Atorvastatin 3.2 4.0 7.9 -0.2 2.8
Illnesses of father: High blood pressure 3.6 4.5 8.8 3.0 0.4
Alcohol drinker status: Never 0.1 0.2 0.2 -0.3 0.5
Ever smoked 1.5 2.7 4.4 -2.1 1.0
Basal metabolic rate 0.2 1.4 2.7 1.6 -0.0
Leg fat percentage (left) 1.0 3.7 4.0 -1.8 2.0
Arm fat-free mass (left) 0.3 1.5 3.0 1.7 -0.0
Number of operations (self-reported) 1.6 2.4 4.3 -2.1 0.7
Average weekly beer plus cider intake 0.2 0.3 0.4 0.7 -0.4
Irritability 0.9 1.6 1.7 -1.3 -1.2
Risk taking 2.2 3.2 5.8 -0.7 -2.4
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.2 0.3 -0.5
Fractured/broken bones in last 5 years 1.1 1.4 1.7 1.0 1.3
Age started oral contraceptive pill 2.3 2.8 5.6 -0.3 2.4
Diastolic blood pressure, automated reading 1.2 3.8 5.5 -1.4 -2.4
Ever depressed for a whole week 0.8 1.0 2.0 -0.3 1.4
Unable to work because of sickness or disability 1.2 1.6 1.7 -1.2 1.3
Commuting to job workplace: Cycle 0.3 0.3 0.6 0.2 -0.8
Myopia 0.6 0.9 1.2 -1.1 0.7
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.8 0.2 -0.9
Cholesterol lowering medication 1.7 2.6 4.8 0.5 2.2
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 1.5 -1.0 1.2
Pain experienced in last month 0.2 0.4 0.7 -0.3 0.8
Supplements: Calcium 3.7 4.0 6.7 -1.2 -2.6
Basal cell carcinoma (self-reported) 0.3 0.4 0.8 0.0 -0.9
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.1 -1.4 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 0.7 -0.8 0.8
Heart disease (siblings) 0.1 0.2 0.4 -0.6 0.0
Alcohol drinker status: Previous 3.8 4.3 4.9 -1.9 2.2
Pack years of smoking 0.6 0.9 1.5 -0.5 1.2
Impedance of whole body 3.9 19.8 36.5 -1.8 -6.0
Leg fat mass (left) 0.4 1.6 2.5 -0.8 1.6
Arm predicted mass (left) 0.2 1.3 2.5 1.6 0.2