TWAS hub - PARP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.129	0.0679	0.0087	0.079	NA	0.082	NA	0.078	3.0e-06	NA	2.0e-06	NA	3.5e-06
2	GTEx	Pituitary	0.460	0.1400	0.0064	0.145	NA	0.068	NA	0.113	1.8e-04	NA	8.8e-03	NA	9.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bilateral oophorectomy (both ovaries removed)	5.4	6.2	10.4	-3.2	1.4
Smoking status: Previous	5.3	7.9	13.2	-3.6	1.6
Had menopause	5.0	6.2	12.2	-0.5	3.5
Time employed in main current job	4.8	5.5	7.0	-2.7	2.0
Hand grip strength (right)	4.2	11.3	20.6	1.5	-4.5
Age when periods started (menarche)	4.2	10.0	14.7	2.3	-3.8
Had other major operations	3.9	4.7	9.3	-3.0	-0.5
Impedance of whole body	3.9	19.8	36.5	-1.8	-6.0
Number of full brothers	3.8	4.7	5.3	-2.0	2.3
Alcohol drinker status: Previous	3.8	4.3	4.9	-1.9	2.2
Supplements: Calcium	3.7	4.0	6.7	-1.2	-2.6
Past tobacco smoking	3.6	6.6	10.0	3.2	-1.8
Illnesses of father: High blood pressure	3.6	4.5	8.8	3.0	0.4
Impedance of leg (right)	3.5	16.9	31.1	-1.7	-5.6
Impedance of leg (left)	3.5	17.1	32.4	-1.4	-5.7
Number of live births	3.5	4.9	6.3	-1.9	2.5
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.0	10.5	1.9	-3.2
Medication: Atorvastatin	3.2	4.0	7.9	-0.2	2.8
Frequency of tiredness / lethargy in last 2 weeks	3.1	5.0	8.1	-2.8	-1.4
Impedance of arm (left)	3.1	14.5	25.4	-1.9	-5.0
Smoking Status	3.0	7.1	11.0	-3.3	1.8
Tense / ‘highly strung’	3.0	5.0	9.1	-1.0	-3.0
Hand grip strength (left)	2.9	7.5	14.4	0.8	-3.8
Medication: Levothyroxine sodium	2.8	4.7	6.6	1.7	2.6
Ever used hormone-replacement therapy (HRT)	2.6	3.3	5.1	-1.2	2.3
Hayfever, allergic rhinitis or eczema	2.6	5.6	9.8	1.2	-3.1
Impedance of arm (right)	2.6	12.4	21.7	-1.7	-4.7
Hair/balding pattern: Pattern 3	2.6	3.8	6.8	-2.6	-0.9
Standing height	2.6	25.8	47.6	2.0	-6.9
Osteoarthritis (self-reported)	2.6	3.4	4.8	-2.2	1.4
Average weekly fortified wine intake	2.5	3.0	4.4	1.2	-2.1
Body Mass Index (BMI) (2010)	2.4	3.2	3.7	-1.7	1.9
Comparative body size at age 10	2.4	6.6	12.8	-0.6	3.6
Age started oral contraceptive pill	2.3	2.8	5.6	-0.3	2.4
Height	2.2	41.9	80.1	1.9	-8.9
Body mass index (BMI)	2.2	9.5	18.7	-0.5	4.3
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	5.7	0.2	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	4.5	-2.1	-1.2
Mother’s age at death	2.2	2.8	3.9	1.3	2.0
Pain type(s) experienced in last month: Hip pain	2.2	2.8	4.0	-2.0	-1.2
Risk taking	2.2	3.2	5.8	-0.7	-2.4
Age at first live birth	2.1	3.7	7.3	2.7	-0.4
Depressed Affect (Nagel 2018)	2.0	4.2	8.0	-2.8	-0.7
Reaction Time	2.0	3.8	6.2	-1.2	2.5
BMI	2.0	11.4	21.9	-0.9	4.7
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	2.6	1.6	1.4
Length of working week for main job	2.0	2.2	2.9	-1.2	-1.7
Mean time to correctly identify matches	2.0	3.9	6.3	-1.2	2.5
Long-standing illness, disability or infirmity	2.0	3.0	4.8	-2.2	1.1
Medication: Atenolol	1.9	2.4	4.0	-0.9	2.0
High blood pressure (mother)	1.9	2.6	4.6	-2.1	0.8
Peak expiratory flow (PEF)	1.9	4.4	4.9	2.2	-2.0
Medication: Omeprazole	1.9	2.3	2.7	-1.4	1.6
Family relationship satisfaction	1.9	2.4	4.6	0.4	-2.1
Ever had hysterectomy (womb removed)	1.8	2.0	3.1	-1.8	1.0
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	4.2	2.1	-1.2
Medication: Amlodipine	1.8	2.6	4.3	0.9	2.1
Leg pain on walking	1.8	2.2	3.9	0.7	-2.0
Back pain experienced in last month	1.8	2.6	4.5	-0.9	-2.1
Ever taken oral contraceptive pill	1.8	2.0	4.0	-2.0	-0.3
Depression (Nagel 2018)	1.7	2.5	4.8	-2.2	0.5
Sitting height	1.7	11.8	21.2	1.6	-4.6
Medication: Ramipril	1.7	2.1	4.2	-0.4	2.0
Exposure to tobacco smoke at home	1.7	1.9	2.6	-1.6	1.1
Asthma (self-reported)	1.7	3.4	5.8	-2.4	1.1
Cholesterol lowering medication	1.7	2.6	4.8	0.5	2.2
LDL Cholesterol	1.6	2.6	3.4	-1.3	1.9
Number of operations (self-reported)	1.6	2.4	4.3	-2.1	0.7
Neuroticism (Nagel 2018)	1.5	3.5	6.1	-2.5	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	3.9	-2.0	-1.7
Arm fat percentage (right)	1.5	6.1	8.7	-1.9	2.9
Prospective memory result	1.5	1.9	3.0	-1.7	-0.8
Medication for pain relief, constipation, heartburn	1.5	2.5	3.1	1.4	-1.8
Ever smoked	1.5	2.7	4.4	-2.1	1.0
Allergy or Eczema	1.4	3.6	5.3	2.3	-1.4
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	2.7	1.6	1.6
Schizophrenia vs Biploar Disorder	1.3	1.7	2.1	1.4	-1.1
Mean Putamen Volume	1.3	1.4	2.5	1.6	-0.6
Relative age of first facial hair	1.3	2.6	3.8	1.2	-1.9
Qualifications: None of the above	1.3	2.9	5.2	-0.7	2.3
Asthma	1.3	2.6	4.3	-2.1	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	3.2	-1.8	0.1
Health satisfaction	1.3	1.7	3.4	-0.2	-1.8
Chest pain or discomfort	1.3	1.9	2.5	-1.1	-1.6
Arm fat percentage (left)	1.3	5.0	6.7	-1.8	2.6
Major Depression (MDD)	1.2	1.4	2.3	0.7	-1.5
Age at First Birth	1.2	1.7	2.6	0.9	-1.6
Neuroticism (2016)	1.2	1.8	3.5	-0.0	-1.9
Chronotype (morning person)	1.2	2.7	4.9	-2.2	0.7
Fed-up feelings	1.2	2.3	3.8	-0.9	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	3.1	-1.5	-1.8
Fluid intelligence score	1.2	2.5	3.6	1.9	-1.2
Medication: Paracetamol	1.2	2.1	3.9	-0.5	2.0
Migraine (self-reported)	1.2	1.6	2.1	1.4	-1.0
Medication: Ibuprofen	1.2	1.5	2.9	-1.7	-0.2
Commuting to job workplace: Public transport	1.2	1.4	2.2	-1.5	0.8
Medication: Blood pressure	1.2	2.3	3.8	0.9	2.0
Diastolic blood pressure, automated reading	1.2	3.8	5.5	-1.4	-2.4
Unable to work because of sickness or disability	1.2	1.6	1.7	-1.2	1.3
Medication: Metformin	1.1	1.5	2.0	1.4	1.0
Mouth/teeth dental problems: Dentures	1.1	1.9	3.8	0.1	1.9
Blood clot in the leg (DVT)	1.1	1.4	1.9	-1.4	1.0
Leg fat percentage (right)	1.1	4.1	4.2	-2.0	2.0
Fractured/broken bones in last 5 years	1.1	1.4	1.7	1.0	1.3
Rheumatoid Arthritis	1.0	1.4	2.0	1.0	1.4
Medication for hormone replacement therapy	1.0	1.1	2.1	-0.1	-1.5
Medication: Co-codamol	1.0	1.1	2.2	-1.5	0.4
Waist circumference	1.0	3.5	6.7	-0.7	2.6
Hearing difficulty/problems with background noise	1.0	1.6	3.0	-1.7	0.5
Noisy workplace	1.0	1.3	2.5	-0.2	1.6
Breastfed as a baby	1.0	1.2	1.9	1.4	0.8
Loud music exposure frequency	1.0	1.1	2.2	1.5	0.2
Wheeze or whistling in the chest in last year	1.0	1.8	2.9	-1.7	-0.8
Number of full sisters	1.0	1.3	2.5	-0.2	1.6
Overall health rating	1.0	2.1	4.0	-2.0	-0.5
Mood swings	1.0	1.7	2.4	-1.0	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.1	0.4	1.4
Mineral and other dietary supplements	1.0	1.3	1.7	1.3	1.0
Osteoporosis (self-reported)	1.0	1.2	2.2	-0.5	-1.5
Leg fat percentage (left)	1.0	3.7	4.0	-1.8	2.0
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	1.5	-1.0	1.2
Heel T-Score	0.9	6.8	12.3	-1.2	-3.5
Supplements: Zinc	0.9	0.9	1.0	1.0	1.0
Relative age voice broke	0.9	1.3	2.0	0.8	-1.4
Stomach or abdominal pain in last month	0.9	1.1	1.6	-0.7	-1.3
Number of incorrect matches in round	0.9	1.4	1.5	-1.2	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	2.7	0.5	-1.6
Heart attack	0.9	1.2	2.0	-1.4	-0.6
Pain all over the body in last month	0.9	1.0	1.5	-0.7	1.2
Falls in the last year	0.9	1.2	1.3	-1.1	1.1
Pulse wave reflection index	0.9	1.2	2.1	1.4	0.5
Age at last live birth	0.9	1.3	2.3	1.5	0.5
Eye problems/disorders: Cataract	0.9	1.0	2.1	0.1	1.4
Number of self-reported non-cancer illnesses	0.9	1.6	2.1	-1.5	1.0
Medication: Bendroflumethiazide	0.9	1.3	2.2	0.7	1.5
Irritability	0.9	1.6	1.7	-1.3	-1.2
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.1	-1.4	-0.5
Intelligence (Savage-Jansen 2018)	0.8	2.5	5.0	2.2	0.3
Primary Biliary Cirrhosis	0.8	1.2	2.3	-0.2	1.5
Ulcerative Colitis	0.8	1.2	2.0	0.6	1.4
Neuroticism	0.8	1.9	3.0	-1.7	-0.9
Number of treatments/medications taken	0.8	1.4	1.9	-1.4	0.9
Taking other prescription medications	0.8	1.2	1.5	-1.2	-1.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.4	0.5	-1.2
Exposure to tobacco smoke outside home	0.8	1.1	1.5	-1.2	0.9
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.8	0.4	-1.3
Financial situation satisfaction	0.8	1.0	1.9	0.1	-1.4
Ever depressed for a whole week	0.8	1.0	2.0	-0.3	1.4
Worry (Nagel 2018)	0.7	1.5	2.6	-1.6	-0.6
Systolic Blood Pressure	0.7	3.7	6.2	-1.1	-2.5
Respiratory disease	0.7	1.5	2.5	-1.6	0.7
Hearing difficulty/problems: Yes	0.7	1.1	2.1	-0.4	1.5
Forced vital capacity (FVC)	0.7	2.9	4.0	1.3	-2.0
Neuroticism score	0.7	1.4	1.8	-1.3	-1.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	2.9	1.3	-1.7
Number of children fathered	0.7	0.8	1.2	-1.1	-0.7
Emphysema/chronic bronchitis	0.7	0.8	1.4	1.2	0.3
Pulse rate, automated reading	0.7	2.3	4.5	-0.3	-2.1
Comparative height size at age 10	0.7	4.1	7.6	0.7	-2.8
Had major operations	0.7	0.9	1.1	0.8	1.0
Medication: Aspirin	0.7	0.9	1.8	-0.1	1.4
Average weekly red wine intake	0.7	1.1	2.2	-0.2	-1.5
Medication: Aspirin	0.7	0.9	1.8	-0.2	1.4
Arm fat mass (left)	0.7	3.0	4.9	-1.0	2.2
Medication: Paracetamol	0.7	1.1	1.7	-0.8	1.3
Bipolar Disorder (2018)	0.6	0.9	1.7	0.4	1.3
Ulcerative Colitis (UC)	0.6	1.2	2.3	-0.1	1.5
Serious illness, injury or assault to yourself	0.6	0.7	0.8	-0.8	-0.9
Father’s age at death	0.6	0.8	1.6	1.3	-0.0
Worrier / anxious feelings	0.6	1.1	1.4	-0.9	-1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.5	1.6	-0.4
Depression (self-reported)	0.6	0.8	1.3	-1.2	-0.4
Arm fat mass (right)	0.6	2.6	4.9	-0.6	2.2
Headache pain in last month	0.6	1.0	1.9	-1.4	0.2
Worry too long after embarrassment	0.6	1.0	1.0	-1.0	1.0
Eye problems/disorders: None of the above	0.6	0.7	1.4	-0.2	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	-0.1	1.2
Diabetes diagnosed by doctor	0.6	1.0	1.1	1.0	1.0
Miserableness	0.6	1.1	1.3	-0.9	-1.1
High cholesterol (Self-reported)	0.6	1.1	1.3	0.9	1.2
Myopia	0.6	0.9	1.2	-1.1	0.7
Pack years of smoking	0.6	0.9	1.5	-0.5	1.2
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.5	1.6	0.2
Lung FEV1/FVC ratio	0.5	2.6	4.6	-0.8	2.1
Lung FVC	0.5	2.6	4.3	0.9	2.1
Sensitivity / hurt feelings	0.5	0.9	1.8	-1.4	-0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	0.7	-0.9	0.8
Systolic blood pressure, automated reading	0.5	1.6	1.9	-1.4	-1.1
Townsend deprivation index at recruitment	0.5	0.7	1.0	-1.0	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.2	-0.3	-1.1
Allergy	0.5	1.2	2.2	0.5	1.5
Medication: Simvastatin	0.5	0.8	1.5	-0.1	1.2
Trunk fat-free mass	0.5	2.6	5.2	2.3	-0.2
Happiness	0.5	0.6	0.9	0.9	-0.5
Trunk predicted mass	0.5	2.8	5.6	2.4	-0.2
Gout (self-reported)	0.5	0.7	0.8	0.9	-0.7
Birth weight	0.5	1.1	1.6	1.3	-0.7
Forced vital capacity (FVC), Best measure	0.5	1.9	2.9	1.0	-1.7
Body fat percentage	0.5	2.2	3.4	-1.8	1.0
Leg fat mass (right)	0.5	1.8	2.6	-1.0	1.6
Suffer from ‘nerves’	0.5	0.7	1.4	-0.1	1.2
Hypertension (Self-reported)	0.5	1.4	2.7	-0.4	1.6
Breast cancer (self-reported)	0.5	0.6	1.0	-1.0	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	0.7	-0.8	0.8
Supplements: Glucosamine	0.4	0.6	1.0	-0.3	-1.0
Hip circumference	0.4	1.6	3.0	0.5	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	1.3	1.0	-1.2
Birth weight of first child	0.4	0.7	0.7	-0.8	0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.8	-0.5	0.9
High blood pressure (siblings)	0.4	0.5	1.1	-0.1	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.8	-0.9	-0.4
Neck or shoulder pain in last month	0.4	0.6	0.7	0.9	-0.7
Medication: Blood pressure	0.4	0.6	0.8	0.7	0.9
Heart disease (mother)	0.4	0.5	0.8	-0.4	0.9
Arm predicted mass (right)	0.4	1.9	3.6	1.9	-0.4
Whole body fat-free mass	0.4	2.1	4.3	2.1	-0.1
Ever had bowel cancer screening	0.4	0.4	0.8	0.2	-0.9
Medication for cholesterol	0.4	0.6	0.7	-0.7	-0.8
Medication: Gliclazide	0.4	0.5	0.6	-0.6	0.8
Average weekly champagne plus white wine intake	0.4	0.5	0.8	-0.4	-0.9
Guilty feelings	0.4	0.6	1.0	1.0	-0.4
Leg fat mass (left)	0.4	1.6	2.5	-0.8	1.6
Alzheimer’s Disease (including proxy)	0.3	0.4	0.5	-0.7	0.6
Breast Cancer	0.3	0.8	1.6	-0.3	1.2
Ovarian Cancer	0.3	0.4	0.8	-0.9	0.2
Prostate Cancer	0.3	0.5	1.0	-0.1	-1.0
Coronary Artery Disease (CAD)	0.3	0.3	0.5	-0.7	0.4
Fasting Glucose	0.3	0.3	0.6	-0.8	0.2
Lupus	0.3	0.5	1.0	-0.1	-1.0
Average weekly spirits intake	0.3	0.4	0.5	-0.7	-0.5
Angina	0.3	0.4	0.7	0.3	0.8
Pack years adult smoking proportion	0.3	0.5	0.6	-0.5	0.8
Trunk fat percentage	0.3	1.3	2.5	-1.6	0.2
High blood pressure	0.3	0.7	1.4	0.0	1.2
Chronic bronchitis/emphysema (father)	0.3	0.4	0.5	-0.7	0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.5	-0.6	0.7
Diabetes (self-reported)	0.3	0.4	0.7	0.8	0.4
Alcohol intake versus 10 years previously	0.3	0.4	0.7	0.8	0.3
Medication: Cholesterol lowering	0.3	0.5	1.0	-0.2	1.0
Arm fat-free mass (right)	0.3	1.7	3.0	1.7	-0.5
Qualifications: College or University degree	0.3	0.9	1.8	0.0	-1.3
Medication: Seretide 50 evohaler	0.3	0.3	0.6	-0.0	0.8
Knee pain experienced in last month	0.3	0.4	0.4	0.7	-0.6
Leg fat-free mass (right)	0.3	1.5	3.0	1.7	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.5	0.4	0.7
Loneliness, isolation	0.3	0.4	0.5	-0.7	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.7	-0.3	-0.8
Smoking status: Current	0.3	0.4	0.7	-0.4	0.8
Whole body water mass	0.3	1.9	3.8	1.9	-0.0
Leg predicted mass (right)	0.3	1.4	2.7	1.6	0.2
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	0.9	0.3
Medication: Lisinopril	0.3	0.4	0.8	0.9	-0.1
Arm fat-free mass (left)	0.3	1.5	3.0	1.7	-0.0
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.2	-0.8
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	0.0	-0.9
Alzheimer’s Disease (in mother)	0.2	0.3	0.4	-0.4	0.6
Crohns Disease (2017)	0.2	0.5	0.7	-0.8	-0.5
Triglycerides	0.2	0.3	0.3	-0.5	0.5
Blood Red Count	0.2	1.9	3.8	0.3	-1.9
Blood White Count	0.2	1.5	3.0	-0.2	-1.7
Waist Hip Ratio (WHR)	0.2	0.8	0.9	-0.9	-0.9
Tanning	0.2	2.2	4.4	-0.2	-2.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.0	0.8
Leg fat-free mass (left)	0.2	1.0	2.0	1.4	0.2
Current tobacco smoking	0.2	0.4	0.6	-0.4	0.8
Maternal smoking around birth	0.2	0.2	0.4	-0.3	0.6
Qualifications: CSEs or equivalent	0.2	0.3	0.3	-0.6	-0.5
Multivitamins +/- minerals	0.2	0.3	0.5	0.7	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.2	0.4	0.5
Leg predicted mass (left)	0.2	1.1	2.1	1.5	0.2
Alcohol usually taken with meals	0.2	0.4	0.7	0.2	-0.8
Financial difficulties in last 2 years	0.2	0.3	0.6	0.8	0.2
Mouth/teeth dental problems	0.2	0.2	0.5	-0.0	-0.7
Medication: Lansoprazole	0.2	0.2	0.4	0.4	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.7	-0.4
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	0.2	-0.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	-0.6	0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	0.0	-0.8
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.6	-0.1
Angina (self-reported)	0.2	0.2	0.4	0.3	0.7
Alcohol intake frequency.	0.2	0.5	0.6	0.5	0.8
Illnesses of father: Heart disease	0.2	0.3	0.4	0.4	0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.1	0.7
Friendships satisfaction	0.2	0.3	0.6	0.2	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.3	-0.6
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	-0.7	-0.2
Hearing aid user	0.2	0.2	0.3	-0.5	0.3
Basal metabolic rate	0.2	1.4	2.7	1.6	-0.0
Average weekly beer plus cider intake	0.2	0.3	0.4	0.7	-0.4
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.8	0.2	-0.9
Pain experienced in last month	0.2	0.4	0.7	-0.3	0.8
Arm predicted mass (left)	0.2	1.3	2.5	1.6	0.2
Schizophrenia (2018)	0.1	0.2	0.3	-0.5	-0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.2	0.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	-0.3	0.7
HbA1C	0.1	0.1	0.2	0.4	0.2
Schizophrenia (2014)	0.1	0.2	0.4	-0.6	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.4	0.0
Cardiovascular Disease	0.1	0.3	0.6	-0.8	0.0
Hypothyroidism (self reported)	0.1	0.3	0.5	0.4	0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.4	-0.6	0.3
Vitamin and mineral supplements	0.1	0.1	0.2	-0.4	-0.2
Diabetes (father)	0.1	0.1	0.2	-0.4	0.2
Diabetes (mother)	0.1	0.1	0.1	0.1	0.4
Severe depression (siblings)	0.1	0.2	0.2	-0.3	0.5
Trunk fat mass	0.1	0.3	0.6	-0.8	0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.4	0.3
Illnesses of siblings	0.1	0.1	0.2	-0.1	-0.4
Weight	0.1	0.5	0.7	0.6	0.9
Pulse rate	0.1	0.2	0.3	-0.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.3	-0.3
Lung cancer (father)	0.1	0.2	0.3	0.6	0.1
Illnesses of mother	0.1	0.2	0.2	0.5	-0.3
Glaucoma (self-reported)	0.1	0.1	0.1	-0.0	0.3
Pulse wave peak to peak time	0.1	0.1	0.2	0.1	-0.4
Medication: Allopurinol	0.1	0.1	0.2	0.4	-0.1
Whole body fat mass	0.1	0.5	0.7	-0.6	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.5	-0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.2	0.4	0.4
Supplements: Vitamin C	0.1	0.1	0.2	-0.0	0.4
Wears glasses or contact lenses	0.1	0.1	0.2	-0.1	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.5	-0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	-0.1	-0.6
Alcohol drinker status: Never	0.1	0.2	0.2	-0.3	0.5
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.2	0.3	-0.5
Heart disease (siblings)	0.1	0.2	0.4	-0.6	0.0
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.1	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	-0.1	-0.2
HDL Cholesterol	0.0	0.1	0.1	-0.4	-0.1
Blood Eosinophil Count	0.0	0.3	0.4	-0.6	-0.5
Blood Platelet Count	0.0	0.3	0.6	-0.1	0.8
Hair Pigment	0.0	1.3	1.5	-1.0	1.2
Nervous feelings	0.0	0.0	0.0	-0.1	-0.2
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	0.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	-0.0	-0.2
Chronic bronchitis/emphysema (mother)	0.0	0.1	0.1	-0.1	0.3
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	0.0	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	0.1	-0.3
Qualifications: nursing, teaching	0.0	0.1	0.1	-0.3	0.1
Commuting to job workplace: Walk	0.0	0.0	0.0	-0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.3	-0.2

Hub : Genes

PARP3

Models

Trait associations