Hub : Genes

PCBD2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.1450	0.0520	2.0e-03	0.101	NA	0.091	NA	0.076	7.1e-06	NA	2.0e-05	NA	1.0e-04
2	GTEx	Nerve Tibial	0.1353	0.0436	5.7e-04	0.050	NA	0.041	NA	0.067	1.8e-04	NA	7.2e-04	NA	1.7e-05
3	GTEx	Skin Sun Exposed Lower leg	0.1440	0.0390	4.3e-05	0.067	NA	0.087	NA	0.105	3.1e-06	NA	1.1e-07	NA	5.1e-09
4	GTEx	Testis	0.1810	0.0540	1.8e-04	0.190	NA	0.163	NA	0.179	7.5e-09	NA	1.1e-07	NA	2.3e-08
5	GTEx	Thyroid	0.2520	0.0490	2.5e-10	0.150	NA	0.145	NA	0.140	1.4e-11	NA	3.5e-11	NA	7.9e-11
6	METSIM	Adipose	0.0372	0.0168	1.2e-02	0.009	0.017	0.000	0.017	0.002	1.6e-02	0.00110	2.8e-01	0.0013	1.3e-01
7	TCGA	Glioblastoma Multiforme	0.3090	0.1630	2.1e-03	0.112	0.108	0.112	NA	0.122	2.9e-04	0.00037	2.8e-04	NA	1.5e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.8	2.1	-1.4	0.0	-0.2	0.0	-1.1	-0.8	1.4
Bipolar Disorder or Schizophrenia	0.2	0.4	1.1	-0.8	-0.4	0.1	-1.0	-0.8	-0.1	0.4
Depressed Affect (Nagel 2018)	1.7	3.5	5.2	1.8	2.3	2.1	2.2	2.0	1.5	-0.7
Depression (Nagel 2018)	0.2	0.3	0.7	0.6	0.8	0.8	0.6	0.5	0.2	0.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.7	-0.9	-1.1	-0.8	-1.3	-0.8	-0.7	0.6
Neuroticism (Nagel 2018)	0.2	0.5	1.6	0.2	0.6	0.8	0.8	-0.0	1.3	0.5
Schizophrenia (2018)	0.0	0.1	0.3	0.0	0.0	0.2	-0.1	-0.3	0.5	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.4	-0.1	-0.2	-0.8	0.6	0.3	0.3	-1.2
Worry (Nagel 2018)	0.6	1.2	2.6	-1.0	-1.0	-0.6	-1.3	-1.6	0.7	1.2
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	1.0	1.0	0.8	1.2	0.7	0.5	-0.5
Alzheimer’s Disease (in father)	0.6	0.6	1.9	-0.5	-1.1	-0.5	-1.4	0.4	-0.5	0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	2.6	0.9	0.5	0.7	0.6	1.6	0.1	-0.7
Crohns Disease (2017)	0.4	0.8	2.3	-0.6	-0.5	-0.4	-0.9	-0.6	-1.2	1.5
Irritable Bowel Disease (IBD)	0.6	1.3	9.1	-0.1	0.0	0.1	-0.4	0.1	-3.0	0.1
Ulcerative Colitis (UC)	1.0	1.9	11.8	0.1	0.1	0.2	-0.1	0.2	-3.4	-1.2
Major Depression (MDD)	0.4	0.5	1.1	-0.1	0.1	0.9	-1.0	0.7	-1.1	0.4
Reaction Time	0.6	1.0	3.3	-1.3	-0.6	-0.7	-0.8	-1.8	0.3	0.9
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.7	-1.1	-1.2	-1.1	-1.3	-0.7	-0.8	0.2
Breast Cancer	0.3	0.7	2.3	-1.3	-0.8	-1.5	0.0	-0.4	-0.1	0.5
Ovarian Cancer	0.5	0.7	4.1	-0.3	0.0	-0.4	0.6	0.6	2.0	-0.2
Prostate Cancer	0.3	0.5	2.4	-0.2	0.6	0.4	0.4	-0.5	0.2	1.6
Age at First Birth	0.3	0.4	1.0	-0.7	-0.3	0.0	-0.8	-1.0	-0.7	-0.3
Bipolar Disorder (2011)	1.5	1.4	3.0	-1.3	-0.9	-0.6	-1.6	-1.1	-0.4	1.7
Body Mass Index (BMI) (2010)	0.7	0.9	1.5	-0.5	-1.2	-1.1	-1.0	0.2	-1.2	1.0
Coronary Artery Disease (CAD)	1.7	2.0	5.4	-1.5	-1.0	-1.0	-1.7	-0.9	-1.1	2.3
Crohns Disease (2012)	0.1	0.1	0.4	0.3	0.4	0.4	-0.0	0.1	-0.1	0.6
Mean Putamen Volume	1.5	1.7	3.8	-1.8	-1.7	-1.9	-1.0	-0.4	-0.8	-0.2
Fasting Glucose	0.2	0.2	1.1	-0.4	-0.3	0.5	0.2	0.1	1.1	-0.3
HbA1C	1.6	1.8	5.3	-1.5	-0.9	-1.4	-2.3	-1.3	0.2	0.7
HDL Cholesterol	0.1	0.2	0.6	-0.1	0.1	0.1	0.0	-0.8	0.6	-0.2
LDL Cholesterol	0.2	0.2	1.1	0.3	0.1	0.1	0.2	0.4	-0.5	-1.1
Lupus	0.8	1.3	3.7	-1.4	-0.7	-0.8	-0.7	-0.7	-1.2	1.9
Neuroticism (2016)	0.2	0.3	0.6	-0.8	0.0	-0.4	-0.5	-0.7	0.5	0.7
Primary Biliary Cirrhosis	0.4	0.6	2.0	0.6	0.6	1.1	-0.2	0.1	-0.1	1.4
Rheumatoid Arthritis	0.5	0.7	1.9	1.4	0.8	0.9	0.7	1.2	0.2	-0.3
Schizophrenia (2014)	0.1	0.2	0.3	0.5	0.4	0.6	0.3	0.5	0.5	-0.4
Triglycerides	0.1	0.1	0.3	-0.2	-0.5	-0.6	-0.4	0.4	0.3	-0.1
Type 2 Diabetes (T2D) (2012)	6.2	7.2	20.3	-1.9	-1.4	-0.9	-3.1	-2.4	-2.8	4.5
Ulcerative Colitis	0.7	1.1	5.7	-0.1	0.1	0.2	-0.3	0.0	-2.4	-1.3
Blood Eosinophil Count	0.1	0.9	2.4	0.4	-0.6	0.1	-1.0	1.2	-1.5	-1.0
Blood Platelet Count	0.3	3.8	12.0	-3.5	-1.1	-1.6	-0.9	-2.7	-0.6	1.5
Blood Red Count	0.2	1.8	4.7	1.6	1.0	1.1	0.9	2.2	0.4	-1.5
Blood White Count	0.1	0.6	1.7	-1.1	-0.6	-1.3	0.5	-0.1	-0.1	-0.7
Heel T-Score	0.1	1.2	4.6	0.6	-0.2	0.1	0.1	2.1	0.1	-1.8
BMI	0.5	3.1	13.5	-0.3	-1.6	-1.5	-1.4	1.0	-3.7	0.4
Height	0.7	14.0	45.9	-3.5	-0.4	-0.9	-0.6	-4.8	6.8	3.9
Waist Hip Ratio (WHR)	0.0	0.2	0.6	-0.8	-0.1	-0.0	-0.2	-0.3	-0.8	-0.3
Systolic Blood Pressure	0.3	1.4	4.1	1.7	0.7	0.9	0.5	2.0	-0.7	-0.8
Smoking Status	0.5	1.2	2.4	-0.5	-1.5	-1.5	-1.2	-0.5	-0.7	-1.2
Allergy or Eczema	0.2	0.4	2.2	0.9	0.1	-0.1	0.1	-0.0	-0.1	1.5
Cardiovascular Disease	0.4	1.5	4.8	1.4	0.9	1.3	0.4	2.2	-1.0	-0.5
Hypothyroidism (self reported)	0.1	0.2	1.1	0.2	0.2	0.1	0.0	1.0	0.4	0.3
Respiratory disease	0.2	0.5	1.3	0.3	0.8	0.3	0.8	0.5	0.6	1.2
Type 2 Diabetes (T2D) (2018)	3.6	6.7	11.2	-3.0	-2.7	-2.7	-2.6	-3.4	-1.4	1.9
Lung FEV1/FVC ratio	0.1	0.7	3.2	0.2	-0.6	-0.9	-0.0	0.6	-0.5	-1.8
Lung FVC	1.2	6.0	10.6	2.1	3.0	2.5	3.2	2.4	2.4	-0.7
Neuroticism	1.0	2.4	3.7	-1.9	-1.5	-1.2	-1.6	-1.9	0.2	1.8
Chronotype (morning person)	0.3	0.7	2.3	0.3	0.4	0.6	-0.1	0.7	1.3	1.5
Hair Pigment	0.1	2.8	11.5	-1.3	-0.6	-0.6	-1.1	-1.4	-3.4	1.8
Tanning	0.5	6.5	15.8	2.2	2.2	2.0	2.1	4.0	2.3	-2.5
Hand grip strength (left)	0.3	0.9	1.8	0.6	1.3	1.1	1.0	-0.0	-0.1	1.3
Number of treatments/medications taken	0.5	1.0	1.6	-1.0	-1.3	-1.0	-1.2	-1.2	0.5	0.4
Average weekly spirits intake	0.5	0.6	0.9	-0.8	-1.0	-0.9	-0.9	-0.6	-0.3	-0.6
Sensitivity / hurt feelings	0.6	1.0	3.5	-0.6	-0.8	-0.3	-1.2	-1.0	-1.9	0.2
Frequency of depressed mood in last 2 weeks	1.8	2.6	5.1	2.3	2.1	2.0	1.6	0.7	-1.0	0.3
Hearing difficulty/problems: Yes	0.4	0.6	1.5	-0.3	-0.2	0.6	-1.2	-0.1	-1.2	0.8
Relative age of first facial hair	1.0	2.1	5.6	-1.4	-1.6	-1.3	-1.6	-2.4	0.3	-0.3
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.3	-1.8	-1.2	-1.3	-1.2	-1.1	-0.7	1.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.7	-0.1	-0.3	0.3	-1.3	0.1	-0.0	0.4
Ever had hysterectomy (womb removed)	1.0	1.1	5.1	-0.0	-0.2	-0.3	0.3	-0.1	1.5	-2.3
Systolic blood pressure, automated reading	0.2	0.7	1.9	-0.1	-1.0	-0.7	-1.1	0.2	-1.4	-0.2
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	6.2	-2.4	-2.1	-2.5	-1.1	-0.9	0.7	-0.5
Angina	0.6	0.8	1.6	-0.6	-1.3	-1.3	-1.1	-0.1	-0.9	0.3
Medication for hormone replacement therapy	0.3	0.4	1.6	0.3	0.5	0.7	-0.3	-0.0	-1.2	0.4
Vitamin and mineral supplements	0.3	0.4	1.4	0.3	0.5	0.3	0.7	0.4	1.2	-0.8
Supplements: Zinc	0.6	0.6	2.0	-0.9	-1.0	-1.4	-0.3	-0.2	-0.4	0.4
Medication: Co-codamol	0.2	0.3	0.6	-0.2	-0.8	-0.8	-0.3	-0.3	-0.5	-0.5
Medication: Metformin	2.9	4.1	7.3	-2.7	-2.4	-2.5	-1.7	-2.2	-1.1	0.9
Diabetes (father)	1.3	1.6	2.9	-0.8	-1.1	-0.8	-1.5	-1.2	-1.7	1.4
Diabetes (mother)	1.3	1.7	2.8	-1.6	-1.5	-1.2	-1.7	-0.5	-1.5	0.4
Severe depression (siblings)	0.2	0.2	1.1	-0.5	0.0	0.3	-0.3	0.1	0.1	1.1
Pack years adult smoking proportion	2.3	3.6	7.0	2.3	1.6	1.3	2.1	1.9	-0.4	-2.6
Impedance of leg (right)	0.3	1.6	5.2	-1.5	-0.3	0.2	-1.0	-2.3	1.4	-0.5
Leg fat-free mass (left)	0.1	0.3	1.7	0.2	0.1	-0.1	0.0	0.3	-0.2	1.3
Trunk fat percentage	1.2	4.7	7.4	-2.4	-2.7	-2.6	-2.2	-1.2	-2.5	0.3
Hand grip strength (right)	0.5	1.3	3.0	0.8	1.7	1.4	1.7	0.6	0.0	0.5
Townsend deprivation index at recruitment	0.4	0.6	1.0	0.9	0.7	1.0	0.2	0.7	-1.0	0.6
Current tobacco smoking	0.2	0.4	1.6	0.6	-0.5	-0.5	-0.2	0.0	0.5	-1.3
Average weekly fortified wine intake	2.4	2.9	5.7	-1.6	-2.0	-1.4	-2.4	-1.2	-1.7	1.2
Maternal smoking around birth	2.7	3.9	6.1	-2.0	-2.2	-1.5	-2.5	-1.7	-1.9	1.9
Fed-up feelings	3.0	5.4	7.6	2.3	2.7	2.4	2.5	2.8	1.6	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	0.5	0.8	0.8	0.4	0.9	-0.5	0.1
Relative age voice broke	2.3	3.5	6.2	-2.3	-2.1	-1.5	-2.5	-2.3	-0.8	-0.6
Taking other prescription medications	0.2	0.2	0.5	-0.5	-0.6	-0.2	-0.6	-0.2	0.7	-0.1
Age when periods started (menarche)	1.0	2.4	4.5	-2.0	-0.7	0.1	-2.0	-1.1	1.7	2.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	1.3	0.5	0.1	1.2	1.2	-0.1	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	-0.0	0.1	-0.1	0.4	0.8	-0.9	0.7
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.0	0.8	0.8	0.9	1.0	1.4	1.4	-1.1
Qualifications: CSEs or equivalent	3.1	4.1	7.1	2.7	2.3	2.0	2.4	1.7	1.3	-1.2
Serious illness, injury or assault to yourself	0.8	1.0	2.7	-1.0	-1.2	-1.6	-0.1	-0.7	1.1	-0.3
High blood pressure	0.2	0.5	1.7	0.2	-0.4	0.0	-0.6	1.1	-1.3	-0.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	4.5	0.4	-0.1	-0.1	-0.5	-0.5	-0.5	2.1
Multivitamins +/- minerals	0.6	0.8	1.9	-0.7	-0.9	-0.6	-1.1	-0.6	-0.8	1.4
Stomach or abdominal pain in last month	0.9	1.1	3.5	0.3	0.3	-0.1	1.0	1.9	0.4	-1.6
Supplements: Glucosamine	0.5	0.6	1.3	-0.7	-1.0	-1.1	-0.3	-0.7	0.1	-0.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.8	-0.5	-0.7	-0.8	-0.5	-0.4	0.9	0.7
Medication: Atenolol	1.3	1.6	3.2	-1.6	-1.8	-1.8	-1.2	-0.6	-0.0	-0.5
Medication: Levothyroxine sodium	0.3	0.6	1.2	0.2	0.5	0.5	0.5	1.0	0.9	-1.1
Sitting height	0.4	2.8	9.1	-0.7	0.2	-0.1	-0.1	-2.3	2.3	3.0
Chronic bronchitis/emphysema (father)	0.5	0.5	3.0	0.1	-0.3	-0.5	-0.1	0.1	0.6	1.7
High blood pressure (mother)	0.8	1.2	2.4	0.8	1.0	1.5	0.5	1.4	-1.3	-0.4
Body mass index (BMI)	0.8	3.2	12.4	-0.5	-1.9	-1.9	-1.4	1.0	-3.5	0.3
Impedance of leg (left)	0.3	1.5	4.7	-1.5	-0.4	0.1	-1.0	-2.2	1.4	-0.7
Leg predicted mass (left)	0.0	0.3	1.6	0.2	0.1	-0.1	0.0	0.3	-0.1	1.3
Trunk fat mass	0.8	3.4	5.2	-2.0	-2.3	-2.3	-1.9	-1.0	-1.9	0.9
Waist circumference	0.9	3.2	8.3	-1.6	-2.1	-1.9	-1.9	-0.3	-2.9	0.7
Number of incorrect matches in round	0.4	0.7	2.9	-0.5	0.7	0.9	0.3	-0.1	0.6	1.7
Past tobacco smoking	1.3	2.4	4.6	1.7	2.0	2.2	1.3	1.1	1.5	-0.3
Alcohol usually taken with meals	1.0	1.6	4.2	0.8	1.6	0.9	2.1	0.8	1.4	-0.3
Nervous feelings	0.1	0.2	0.8	-0.1	-0.4	-0.2	-0.7	-0.9	0.1	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.1	1.7	1.6	1.8	1.0	0.9	-0.2	-0.3
Hearing difficulty/problems with background noise	0.2	0.3	1.7	-0.2	0.0	0.5	-0.5	-0.1	-1.3	0.4
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	0.1	0.2	-0.3	0.9	0.7	0.4	-0.5
Had menopause	0.8	1.0	2.2	-0.6	-1.5	-1.2	-1.5	-0.9	0.3	0.0
Had other major operations	0.5	0.6	2.1	-0.4	-0.7	-0.7	-0.3	1.4	-0.7	-0.7
Forced vital capacity (FVC)	2.1	8.1	16.3	2.0	3.7	3.5	3.1	1.1	4.0	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	0.2	0.3	0.4	0.3	0.4	-1.0	0.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	4.0	0.5	0.7	1.8	-0.7	0.3	-2.0	0.4
Qualifications: None of the above	0.2	0.5	1.0	-0.9	-1.0	-0.9	-0.7	-0.1	0.0	0.6
Financial difficulties in last 2 years	1.0	1.4	4.8	1.3	0.7	1.2	-0.4	0.9	-2.2	0.6
Mouth/teeth dental problems	0.9	1.4	4.1	1.0	1.0	0.7	1.2	0.5	1.2	-2.0
Heart attack	0.8	1.1	2.1	-1.0	-1.0	-0.9	-1.3	-0.9	-0.3	1.4
Allergy	0.1	0.3	1.6	-0.7	-0.3	-0.1	-0.1	-0.3	-0.2	-1.2
Pain all over the body in last month	3.0	3.2	6.6	-2.6	-2.1	-1.5	-2.5	-1.4	0.1	0.9
Diabetes (self-reported)	2.8	4.4	7.6	-2.8	-2.4	-2.7	-1.5	-2.7	0.5	0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	3.7	0.4	0.1	0.1	-0.0	0.2	-0.1	1.9
Medication: Ramipril	0.1	0.2	0.4	-0.5	-0.4	-0.6	-0.1	0.2	0.0	0.6
Medication: Simvastatin	0.2	0.3	1.0	-0.3	-0.3	0.5	-1.0	-0.4	-0.4	-0.4
Fluid intelligence score	1.6	3.2	4.2	-1.9	-2.0	-2.0	-2.0	-1.5	-1.9	1.1
Illnesses of siblings	0.9	1.3	4.7	0.3	1.3	1.4	0.8	0.2	2.2	0.6
Neuroticism score	0.2	0.5	0.8	-0.9	-0.5	-0.3	-0.7	-0.9	-0.1	0.9
Weight	0.4	1.9	2.9	-1.3	-1.7	-1.7	-1.5	-0.5	-1.3	1.4
Impedance of arm (right)	0.5	2.3	9.1	-1.9	-0.1	-0.1	0.0	-3.0	1.8	-0.5
Arm fat percentage (right)	1.2	4.8	12.5	-1.7	-2.6	-2.6	-2.0	-0.6	-3.5	0.3
Trunk fat-free mass	0.1	0.6	3.6	0.1	-0.1	-0.2	-0.5	-0.1	0.5	1.9
Hip circumference	0.9	3.9	6.2	-1.9	-2.5	-2.3	-2.2	-1.0	-2.3	1.0
Time employed in main current job	0.2	0.3	0.8	0.4	0.7	0.9	0.5	0.2	-0.4	-0.3
Alcohol intake versus 10 years previously	0.9	1.4	2.8	-0.9	-1.1	-1.5	-0.9	-1.3	-0.2	1.7
Father’s age at death	0.6	0.8	3.7	-0.2	0.2	0.2	-0.1	-0.5	1.9	1.1
Worrier / anxious feelings	0.1	0.2	0.6	-0.4	-0.0	0.8	-0.7	-0.5	0.2	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	6.0	1.6	1.3	1.3	1.0	2.5	-1.0	0.4
Falls in the last year	0.7	1.0	2.6	-1.3	-1.3	-1.6	-0.4	-0.1	0.0	-0.9
Hair/balding pattern: Pattern 3	0.3	0.4	1.7	0.6	0.4	0.2	0.6	0.3	-1.3	0.2
Number of live births	0.3	0.5	1.2	-0.2	-0.5	-0.1	-1.1	-0.1	0.8	1.0
Forced expiratory volume in 1-second (FEV1)	2.6	8.8	15.9	2.7	4.0	3.8	3.3	1.8	3.1	-0.4
Pulse rate	0.2	0.3	1.4	0.2	-0.5	-0.3	-0.1	-0.0	-0.4	-1.2
Happiness	0.3	0.3	0.7	0.2	0.5	0.8	-0.5	-0.5	-0.8	0.5
Noisy workplace	0.4	0.5	1.0	0.8	1.0	1.0	0.9	-0.1	0.3	0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.0	0.0	0.3	0.3	-0.1	-1.4	-1.4	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.6	-1.0	-1.1	-1.6	0.0	-1.3	0.2	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.6	2.1	-0.2	-0.3	-0.5	-0.2	-0.4	1.5	1.1
Asthma	0.4	0.8	1.5	0.5	1.1	0.6	1.1	0.6	1.1	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.5	0.0	-0.1	0.2	0.2	-0.2	-0.6
Medication: Cholesterol lowering	1.3	2.0	4.1	-2.0	-1.6	-1.6	-1.4	-1.2	-0.1	1.1
Depression (self-reported)	0.5	0.6	1.2	1.1	0.8	0.8	0.7	0.8	0.6	-0.6
Medication: Lansoprazole	0.3	0.3	1.5	0.3	0.4	0.6	-0.1	1.2	-0.4	0.1
Prospective memory result	0.6	0.7	2.6	-0.6	-0.7	-0.9	-0.2	-0.2	0.9	-1.6
Lung cancer (father)	0.7	0.8	1.6	-1.0	-1.1	-1.2	-0.9	-0.8	-0.1	0.8
Illnesses of mother	0.5	0.7	2.5	-0.2	-0.8	-1.0	-0.6	-1.6	0.5	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.4	11.4	2.6	3.4	3.2	2.7	1.7	2.5	0.3
Pulse wave Arterial Stiffness index	0.3	0.4	1.2	0.1	0.3	0.1	0.3	0.1	1.1	-1.1
Impedance of arm (left)	0.7	3.1	12.2	-2.4	-0.8	-0.4	-0.9	-3.5	1.4	0.1
Arm fat mass (right)	0.9	3.6	7.2	-1.6	-2.4	-2.4	-1.8	-0.3	-2.7	0.7
Trunk predicted mass	0.1	0.5	3.3	0.2	0.1	-0.0	-0.4	0.0	0.5	1.8
Standing height	0.6	5.8	23.6	-1.6	0.7	0.6	-0.0	-2.9	4.9	2.3
Length of working week for main job	1.2	1.3	2.4	1.0	1.0	0.6	1.4	1.5	0.9	-1.1
Exposure to tobacco smoke at home	0.7	0.7	3.9	0.1	-0.1	-0.6	0.6	0.7	0.4	-2.0
Breastfed as a baby	1.9	2.4	4.2	-2.1	-1.6	-1.8	-0.9	-1.4	2.0	-0.3
Tense / ‘highly strung’	0.3	0.6	2.8	0.1	0.6	0.5	0.8	-0.2	1.7	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.1	-1.0	-1.1	-0.7	-1.5	-0.6	-2.0	0.6
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	-0.0	0.3	-0.1	0.5	0.1	-0.1	0.6
Birth weight of first child	0.4	0.7	1.8	-0.4	0.8	0.7	0.6	-1.1	1.3	0.3
Peak expiratory flow (PEF)	1.1	2.5	4.5	1.3	2.1	2.0	1.9	1.5	0.9	-0.8
Pulse wave reflection index	1.1	1.4	3.8	0.8	1.3	0.7	1.5	0.8	1.9	-0.5
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	-0.7	-0.2	-0.2	0.1	-0.2	0.6	0.0
Loud music exposure frequency	0.7	0.7	1.2	-1.0	-1.1	-1.1	-0.8	-1.0	-0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	0.8	0.3	0.7	-0.2	-0.4	-0.7	-0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	5.3	-0.7	-0.7	-0.4	-0.9	0.6	-2.3	-0.1
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.2	-0.2	0.1	-0.5	0.8	0.6	-0.7
Medication: Paracetamol	0.6	0.9	1.8	1.1	1.1	1.3	0.6	1.3	0.7	-0.2
Headache pain in last month	0.5	0.8	1.6	-1.3	-1.0	-0.8	-1.1	-0.2	0.2	1.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.0	1.4	1.1	1.3	0.7	1.1	0.5	-1.0
Glaucoma (self-reported)	0.6	0.7	3.8	-0.1	0.1	0.4	-0.4	-1.0	-0.0	2.0
Gout (self-reported)	1.6	2.2	5.4	-2.2	-1.3	-1.5	-0.6	-2.3	0.4	1.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	-0.2	-0.2	-0.5	0.1	0.8	0.4	-0.2
Medication: Amlodipine	0.5	0.7	2.5	-0.1	-0.6	-1.1	0.4	0.5	0.9	-1.6
Medication: Ventolin 100micrograms inhaler	0.9	1.1	5.9	0.5	0.4	0.8	-0.9	-0.2	-0.4	2.4
Birth weight	0.4	0.9	2.5	-1.0	-0.2	-0.9	0.2	-1.1	1.0	1.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.6	-1.1	-1.6	-1.5	-1.2	-0.5	-1.0	0.7
High blood pressure (siblings)	0.3	0.5	1.5	0.0	-0.7	-1.2	0.2	0.1	-0.7	-0.9
Forced vital capacity (FVC), Best measure	1.8	6.7	12.2	2.3	3.3	3.1	2.6	1.2	3.5	1.1
Body fat percentage	1.3	5.0	10.1	-2.1	-2.8	-2.6	-2.3	-0.8	-3.2	0.3
Leg fat percentage (right)	1.4	5.2	12.7	-1.8	-2.8	-2.5	-2.5	-0.5	-3.6	0.5
Arm fat-free mass (right)	0.1	0.5	2.9	-0.0	-0.4	-0.4	-0.8	0.0	0.1	1.7
Exposure to tobacco smoke outside home	3.7	4.9	8.1	-2.9	-2.8	-2.7	-2.1	-1.5	-2.0	0.7
Comparative body size at age 10	0.3	1.0	3.5	0.2	-0.5	-0.7	0.1	1.2	-1.9	1.0
Number of full brothers	0.1	0.1	0.2	-0.0	-0.4	-0.3	-0.4	-0.0	-0.5	0.3
Worry too long after embarrassment	0.5	0.9	2.4	-1.4	-0.1	-0.1	-0.5	-1.3	-0.3	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.7	-0.0	0.1	0.1	0.2	0.0	0.3	-0.8
Wheeze or whistling in the chest in last year	0.4	0.8	1.3	-1.2	-0.7	-0.8	-1.0	0.3	-1.0	0.9
Number of children fathered	1.0	1.1	2.4	0.8	1.1	0.9	1.2	1.5	0.8	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.9	-1.1	-0.9	-1.2	-0.4	-1.4	0.4	0.8
Age at first live birth	0.2	0.4	0.9	-0.8	-0.2	-0.2	-0.3	-0.8	0.9	0.9
Pulse wave peak to peak time	0.3	0.4	1.7	-0.2	-0.2	-0.1	-0.3	-0.3	-0.7	1.3
Health satisfaction	0.1	0.1	0.3	0.2	0.0	0.3	-0.4	0.1	-0.5	0.3
Shortness of breath walking on level ground	0.5	0.6	2.6	-0.7	-0.5	-0.4	-0.4	0.0	-1.6	-0.6
Qualifications: College or University degree	0.2	0.5	1.7	-0.7	-0.2	-0.4	-0.4	-1.3	-0.8	0.4
Eye problems/disorders: None of the above	2.4	2.8	5.6	2.0	2.0	1.8	1.5	2.4	-0.7	-0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.5	0.2	-0.6	-0.1	-0.8	1.2	-0.7	0.1
Emphysema/chronic bronchitis	0.8	0.9	1.7	-1.0	-1.2	-1.3	-0.9	-0.2	0.3	-1.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.8	-0.2	0.2	0.0	0.1	-0.7	-0.4	0.9
Neck or shoulder pain in last month	0.7	1.0	1.5	0.9	1.0	0.8	1.2	1.2	0.8	-1.0
Medication: Blood pressure	0.1	0.3	0.5	-0.7	-0.3	-0.5	0.1	-0.6	0.3	0.6
Angina (self-reported)	0.5	0.7	1.6	-0.5	-1.2	-1.3	-1.0	-0.0	-0.7	0.1
Migraine (self-reported)	1.9	2.3	4.7	1.4	1.2	0.8	1.5	2.2	1.4	-1.8
Medication: Ibuprofen	0.1	0.1	0.3	0.2	-0.4	-0.5	-0.2	-0.1	-0.1	-0.0
Medication: Allopurinol	0.8	1.1	2.5	-1.5	-0.9	-1.6	0.1	-1.4	0.4	0.1
Medication: Omeprazole	0.3	0.4	1.2	1.1	0.5	0.6	0.6	0.4	-0.3	-0.5
Medication: Seretide 50 evohaler	0.3	0.3	1.3	-0.5	-0.7	-0.1	-1.1	-0.1	0.1	-0.3
Mean time to correctly identify matches	0.7	1.2	2.9	-1.7	-0.9	-0.9	-1.0	-1.6	0.4	0.6
Heart disease (mother)	0.7	0.8	2.5	-0.4	0.0	0.9	-1.1	-0.1	-1.6	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.0	-0.2	-0.5	0.2	-0.5	-0.3	0.7
Whole body fat mass	0.8	3.4	6.2	-1.7	-2.3	-2.2	-2.0	-0.6	-2.5	0.7
Leg fat mass (right)	0.7	2.6	7.7	-1.1	-1.8	-1.6	-1.7	0.1	-2.8	0.6
Arm predicted mass (right)	0.1	0.6	3.3	-0.1	-0.4	-0.3	-0.9	0.1	0.2	1.8
Pulse rate, automated reading	0.2	0.8	3.1	0.8	0.2	0.7	0.0	1.0	-0.4	-1.8
Alcohol intake frequency.	0.2	0.4	1.4	-0.1	-0.4	-0.0	-0.8	0.2	-1.2	0.5
Comparative height size at age 10	0.5	2.6	9.1	-0.0	1.2	0.8	1.0	-1.6	3.0	1.9
Number of full sisters	0.1	0.1	0.3	0.3	-0.3	0.1	-0.6	0.3	-0.5	-0.2
Suffer from ‘nerves’	0.1	0.1	0.3	0.5	-0.1	-0.2	0.0	-0.2	0.5	0.2
Overall health rating	0.9	1.9	3.1	-1.2	-1.4	-1.3	-1.3	-0.6	-1.7	-1.8
Chest pain or discomfort	1.3	1.8	3.5	-1.5	-1.1	-0.7	-1.9	-1.4	-0.7	1.7
Had major operations	0.3	0.3	2.1	-0.2	-0.1	-0.1	0.1	0.1	1.4	-0.3
Age at last live birth	3.5	5.1	8.8	-2.3	-2.2	-1.7	-2.7	-2.4	-1.1	3.0
Family relationship satisfaction	1.2	1.4	3.7	-1.1	-0.7	-0.3	-1.2	-1.6	-0.7	1.9
Leg pain on walking	0.1	0.1	0.5	-0.4	0.2	0.4	0.1	-0.1	0.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	0.8	0.7	0.3	1.0	1.0	1.1	-0.3
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.9	1.3	1.4	1.7	0.8	1.1	-1.3	-0.7
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.7	0.1	0.8	0.8	0.9	0.4	1.6	-0.8
Medication: Aspirin	0.1	0.1	0.3	-0.3	-0.4	-0.5	-0.2	-0.0	-0.3	-0.5
Supplements: Vitamin C	0.2	0.3	1.2	-0.5	-0.3	-0.1	-0.4	-0.5	-1.1	-0.3
Knee pain experienced in last month	1.3	2.0	3.8	-1.7	-2.0	-1.7	-1.6	-0.1	-0.1	-1.3
Hypertension (Self-reported)	0.2	0.5	2.0	0.4	-0.0	0.3	-0.1	1.4	-1.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.0	0.2	0.2	0.2	0.1	1.0	0.7	-0.1
Illnesses of father: Heart disease	0.9	1.3	3.8	-1.4	-1.0	-1.2	-0.7	-0.0	-2.0	0.5
Illnesses of siblings: Diabetes	4.3	5.3	7.6	-2.5	-2.8	-2.3	-2.7	-2.2	-2.2	1.1
Smoking status: Previous	0.5	0.8	1.8	-1.2	-1.1	-1.3	-0.6	-0.6	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.5	0.1	0.7	0.7	0.3	-0.5	0.6	0.7
Whole body fat-free mass	0.1	0.4	2.5	0.1	-0.1	-0.2	-0.4	0.1	0.3	1.6
Leg fat-free mass (right)	0.0	0.2	1.1	0.4	0.3	-0.0	0.3	0.5	0.1	1.0
Arm fat percentage (left)	1.4	5.6	13.1	-2.0	-2.9	-2.7	-2.3	-0.7	-3.6	0.5
Average weekly red wine intake	0.5	0.8	1.6	-1.2	-0.9	-1.3	0.0	-0.6	0.4	-1.0
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.3	-0.8	-0.4	-0.0	-1.0	-1.0	-0.7	1.8
Mood swings	2.2	4.1	7.9	2.4	2.6	2.8	1.8	2.0	-0.0	-0.8
Loneliness, isolation	1.9	2.7	4.9	1.9	2.2	2.1	1.9	1.2	-0.5	-0.8
Long-standing illness, disability or infirmity	1.9	2.9	5.1	-1.9	-2.0	-2.3	-1.3	-2.3	0.1	1.0
Ever had bowel cancer screening	1.0	1.2	3.4	-1.8	-1.2	-1.3	-0.8	-0.8	0.7	-0.1
Diabetes diagnosed by doctor	3.2	5.3	8.3	-2.9	-2.7	-2.9	-2.0	-2.8	-0.4	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.8	-0.8	-0.9	-0.8	-0.8	-0.7	0.1	-0.3
Friendships satisfaction	0.5	0.6	1.4	-0.6	-0.5	-0.0	-0.9	0.3	-1.2	1.2
Qualifications: nursing, teaching	1.3	2.0	4.7	-1.1	-0.7	-0.4	-1.4	-2.2	-1.5	1.9
Commuting to job workplace: Walk	0.3	0.3	0.6	-0.7	-0.5	-0.4	-0.7	-0.8	-0.1	0.1
Eye problems/disorders: Cataract	2.4	2.8	5.9	-2.0	-2.0	-1.7	-1.5	-2.4	0.3	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	4.2	0.1	0.7	1.3	-0.2	0.3	-0.6	2.0
Medication for cholesterol	0.6	1.0	2.5	0.2	0.8	0.3	1.0	-0.7	1.4	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.3	-0.7	-0.7	-0.6	-0.6	-1.1	0.4	-0.8
Back pain experienced in last month	3.4	5.0	7.4	-2.3	-2.7	-2.5	-2.4	-1.9	-1.9	1.6
Mineral and other dietary supplements	0.3	0.3	1.2	0.4	0.4	0.8	-0.3	-0.0	-0.4	1.1
Breast cancer (self-reported)	2.8	3.3	7.0	1.8	1.7	1.2	2.0	2.7	1.6	-1.5
Asthma (self-reported)	0.6	1.2	1.9	0.8	1.4	1.0	1.2	0.8	1.2	1.2
Osteoporosis (self-reported)	0.1	0.2	0.3	0.1	-0.5	-0.6	-0.5	-0.1	-0.2	0.5
Osteoarthritis (self-reported)	1.7	2.2	4.5	-1.2	-1.8	-1.6	-1.6	-2.1	0.4	-1.0
Medication: Aspirin	0.2	0.3	0.6	-0.4	-0.6	-0.8	-0.3	-0.2	-0.4	-0.6
Medication: Gliclazide	1.0	1.2	2.8	-1.7	-1.3	-1.5	-0.6	-0.7	0.1	0.5
Illnesses of father: None of the above (group 1)	0.5	0.7	1.4	-0.8	-0.8	-0.6	-0.9	-1.2	1.0	0.2
Smoking status: Current	0.4	0.6	2.1	0.1	-0.9	-0.9	-0.5	-0.2	0.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.2	8.9	13.5	3.7	3.7	3.5	3.2	2.3	2.4	-1.2
Whole body water mass	0.1	0.5	2.9	0.0	-0.2	-0.3	-0.5	0.1	0.1	1.7
Leg predicted mass (right)	0.0	0.2	0.9	0.4	0.3	0.0	0.3	0.5	0.0	1.0
Arm fat mass (left)	1.1	4.6	8.1	-1.9	-2.8	-2.7	-2.2	-0.5	-2.8	0.9
Number of self-reported non-cancer illnesses	0.4	0.7	2.3	-1.1	-1.1	-1.5	-0.5	0.2	0.0	0.2
Average weekly champagne plus white wine intake	0.5	0.7	1.3	0.7	1.1	0.9	0.9	0.5	0.3	1.1
Miserableness	0.2	0.3	0.6	0.3	0.8	0.6	0.7	0.6	0.0	-0.1
Guilty feelings	0.1	0.2	1.0	-1.0	-0.3	-0.3	-0.2	0.1	-0.0	0.4
Wears glasses or contact lenses	0.1	0.1	0.4	0.7	0.2	0.1	0.5	0.1	0.4	0.2
Ever taken oral contraceptive pill	0.5	0.6	1.9	0.9	1.0	1.4	0.2	-0.1	-0.7	0.5
Hearing aid user	0.8	0.9	1.5	-0.8	-0.5	0.1	-1.1	-1.1	-1.1	1.2
Mother’s age at death	0.6	0.8	2.0	0.3	0.7	0.4	1.4	-0.1	1.3	-1.1
Financial situation satisfaction	2.8	3.5	6.6	2.6	2.2	2.0	1.9	2.1	0.3	-0.4
Tinnitus: Yes, now most or all of the time	2.1	2.4	5.6	1.7	1.9	2.4	1.0	1.6	0.5	1.1
Commuting to job workplace: Public transport	3.6	4.3	7.6	-2.6	-2.5	-2.8	-1.9	-2.3	0.1	-0.1
Eye problems/disorders: Glaucoma	0.5	0.6	2.5	-0.2	-0.1	0.1	-0.5	-1.0	0.4	1.6
Medication: Blood pressure	0.6	1.1	4.5	-0.0	-0.7	-0.5	-0.4	1.4	-0.5	-2.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.4	-0.1	0.1	-0.5	0.2	-0.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.1	0.7	1.0	1.1	0.7	1.0	0.3	-1.0
High cholesterol (Self-reported)	1.1	1.9	4.6	-1.3	-0.8	-0.1	-1.6	-0.7	-2.1	1.9
Medication: Bendroflumethiazide	0.1	0.2	0.7	-0.3	-0.4	0.1	-0.8	0.4	-0.4	-0.4
Medication: Paracetamol	0.3	0.5	1.4	0.5	0.5	0.7	0.2	0.7	0.8	1.2
Medication: Lisinopril	0.2	0.3	0.9	-0.6	-0.4	-0.4	0.3	-0.7	-0.3	-0.9
Medication: Atorvastatin	1.2	1.4	3.0	-1.3	-1.4	-1.7	-0.6	-1.6	0.4	0.4
Illnesses of father: High blood pressure	3.8	4.7	7.6	2.6	2.4	1.9	2.7	2.2	1.1	-1.7
Alcohol drinker status: Never	0.6	0.7	2.0	-0.8	-0.7	-0.6	-1.1	-0.6	-0.3	1.4
Ever smoked	1.2	2.1	3.5	-1.4	-1.8	-1.9	-1.4	-1.5	-1.2	0.5
Basal metabolic rate	0.1	0.5	2.5	-0.2	-0.4	-0.5	-0.6	0.1	-0.2	1.6
Leg fat percentage (left)	1.5	5.3	13.7	-1.7	-2.8	-2.5	-2.4	-0.3	-3.7	0.4
Arm fat-free mass (left)	0.1	0.5	2.0	-0.0	-0.5	-0.5	-0.7	0.4	-0.3	1.4
Number of operations (self-reported)	1.1	1.6	2.8	-1.0	-1.6	-1.7	-0.8	0.4	1.3	-1.6
Average weekly beer plus cider intake	0.3	0.4	1.4	-0.3	-0.5	-0.1	-0.7	0.4	-1.2	0.6
Irritability	0.4	0.7	1.0	-0.8	-0.9	-0.8	-1.0	-1.0	-0.6	0.5
Risk taking	0.8	1.1	2.5	0.6	0.5	0.9	-0.5	1.1	-1.6	1.6
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.7	0.4	1.3	0.8	1.8	1.0	1.9	-1.6
Fractured/broken bones in last 5 years	0.2	0.2	0.6	-0.1	-0.5	-0.8	-0.3	-0.4	0.0	0.6
Age started oral contraceptive pill	0.8	1.0	2.2	-0.8	-0.7	-0.7	-0.7	-0.7	1.5	1.4
Diastolic blood pressure, automated reading	0.8	2.4	5.4	2.1	1.2	1.8	0.4	2.3	-1.4	-0.7
Ever depressed for a whole week	0.3	0.3	0.9	0.3	0.8	1.0	0.5	-0.0	-0.4	-0.4
Unable to work because of sickness or disability	0.4	0.5	1.8	0.3	-0.6	-1.0	0.2	0.4	0.1	-1.3
Commuting to job workplace: Cycle	1.0	1.2	5.9	0.1	0.5	0.0	0.9	0.6	2.4	1.2
Myopia	1.6	2.4	5.0	-1.6	-1.9	-2.2	-0.9	-1.0	-1.8	0.4
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.3	0.3	1.0	0.5	1.2	-0.4	1.5	0.2
Cholesterol lowering medication	0.2	0.3	1.3	0.3	-0.1	0.7	-0.6	-0.1	-1.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.6	0.3	0.3	0.4	0.1	-0.0	-0.1
Pain experienced in last month	0.4	0.7	1.2	1.1	1.1	1.1	0.6	-0.9	-0.4	0.3
Supplements: Calcium	2.3	2.5	6.1	-2.2	-2.0	-2.5	-1.1	-1.2	-0.5	0.0
Basal cell carcinoma (self-reported)	0.3	0.4	1.5	-0.3	-0.2	-0.2	-0.1	-1.2	1.0	0.3
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.1	-1.1	-1.2	-1.0	-1.5	-1.1	-0.5	1.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.4	0.6	0.1	0.3	-0.2	1.2	0.7	-0.6
Heart disease (siblings)	0.8	1.0	4.6	-0.4	-0.3	0.2	-1.0	0.4	-2.1	0.9
Alcohol drinker status: Previous	0.9	1.1	4.5	0.1	-0.6	-0.8	0.4	0.4	1.2	-2.1
Pack years of smoking	2.2	3.3	6.5	2.2	1.6	1.3	2.1	1.8	-0.2	-2.5
Impedance of whole body	0.5	2.8	11.0	-2.2	-0.6	-0.1	-0.9	-3.3	1.6	-0.3
Leg fat mass (left)	0.7	2.6	8.0	-1.0	-1.8	-1.7	-1.6	0.2	-2.8	0.6
Arm predicted mass (left)	0.1	0.6	2.2	-0.2	-0.6	-0.6	-0.9	0.1	-0.3	1.5