Hub : Genes

PCNT

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1170	0.0330	7.5e-11	0.092	0.092	0.099	0.093	0.108	2.8e-11	2.9e-11	4.1e-12	2.3e-11	4.6e-13
2	GTEx	Adipose Subcutaneous	0.0900	0.0390	3.9e-03	0.025	NA	0.015	NA	0.028	3.9e-03	NA	1.9e-02	NA	2.0e-03
3	GTEx	Adipose Visceral Omentum	0.1310	0.0410	1.1e-04	0.094	NA	0.047	NA	0.077	1.3e-05	NA	1.9e-03	NA	8.2e-05
4	GTEx	Artery Coronary	0.4600	0.1280	3.7e-04	-0.009	NA	0.077	NA	0.015	9.5e-01	NA	1.4e-03	NA	9.9e-02
5	GTEx	Brain Nucleus accumbens basal ganglia	0.2640	0.0850	7.5e-05	0.084	NA	0.149	NA	0.112	2.9e-03	NA	8.8e-05	NA	6.6e-04
6	GTEx	Brain Putamen basal ganglia	0.1620	0.0770	9.7e-03	0.145	NA	0.006	NA	0.062	2.7e-04	NA	2.2e-01	NA	1.4e-02
7	GTEx	Cells EBV-transformed lymphocytes	0.1720	0.0720	3.6e-03	0.112	NA	0.076	NA	0.109	1.7e-04	NA	1.8e-03	NA	2.0e-04
8	GTEx	Heart Left Ventricle	0.0895	0.0360	1.5e-03	0.093	NA	0.043	NA	0.055	1.2e-05	NA	2.4e-03	NA	6.8e-04
9	GTEx	Nerve Tibial	0.1455	0.0431	9.7e-06	0.044	NA	0.070	NA	0.094	4.3e-04	NA	1.1e-05	NA	3.4e-07
10	METSIM	Adipose	0.1444	0.0341	1.6e-11	0.072	0.099	0.095	0.104	0.099	5.5e-11	1.4e-14	4.5e-14	2.7e-15	1.5e-14
11	YFS	Blood	0.2164	0.0371	0.0e+00	0.108	0.149	0.143	0.157	0.133	1.8e-33	2.3e-46	1.9e-44	5.5e-49	4.1e-41
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0621	0.0380	5.9e-04	0.050	0.035	0.025	NA	0.043	2.6e-06	8.2e-05	6.4e-04	NA	1.2e-05
13	TCGA	Pancreatic Adenocarcinoma	0.1160	0.0640	5.2e-03	0.043	0.054	0.040	NA	0.029	6.5e-03	2.6e-03	8.5e-03	NA	2.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	6.5	10.3	26.4	-3.5	2.0	1.8	1.7	-3.8	-1.1	-3.4	-3.3	4.4	2.6	5.1	3.4	2.9
Bipolar Disorder or Schizophrenia	2.1	5.1	18.3	-2.2	1.4	2.5	1.5	-1.4	-0.8	-1.6	-1.6	4.3	1.7	2.8	2.1	3.1
Depressed Affect (Nagel 2018)	0.5	1.1	4.2	0.6	-1.7	-0.9	-1.2	-0.3	-0.4	-0.8	-0.7	-0.4	-1.3	0.9	-0.9	-2.1
Depression (Nagel 2018)	0.6	0.9	3.2	1.5	-1.4	-0.4	-0.2	0.4	-1.0	-0.2	-0.1	-0.0	-1.6	-0.3	-0.8	-1.8
Intelligence (Savage-Jansen 2018)	0.5	1.4	4.1	-1.7	-0.8	-1.5	-1.0	-1.0	0.0	-0.9	0.0	-1.9	-0.6	-2.0	-1.5	-0.1
Neuroticism (Nagel 2018)	0.5	1.2	3.4	0.8	-1.8	-1.5	-0.6	-0.7	0.1	-1.1	-0.9	0.4	-1.7	0.1	-0.9	-1.7
Schizophrenia (2018)	0.5	1.0	3.7	0.0	0.2	1.7	0.4	1.2	-0.2	0.6	0.7	1.9	0.1	-0.5	-0.0	1.7
Schizophrenia vs Biploar Disorder	2.1	2.7	8.2	1.4	-0.9	-1.1	-1.2	1.5	0.7	1.8	1.5	-2.9	-0.8	-2.7	-1.8	-1.5
Worry (Nagel 2018)	0.3	0.6	1.7	1.0	-1.1	-1.0	-0.5	-0.1	0.5	-0.6	-0.6	0.8	-1.3	-0.9	-0.7	-0.6
Alzheimer’s Disease (in mother)	1.0	1.2	4.4	2.1	0.1	1.3	1.4	0.5	0.9	0.9	0.5	1.6	-1.2	0.5	1.1	-0.1
Alzheimer’s Disease (in father)	2.1	2.2	8.6	1.6	1.2	0.7	1.5	1.7	-0.2	2.2	2.9	-0.1	0.5	-2.1	0.4	1.0
Alzheimer’s Disease (including proxy)	1.6	2.4	7.2	2.7	0.6	1.4	2.2	1.6	0.7	2.4	2.2	0.8	-0.7	-0.6	0.9	0.5
Crohns Disease (2017)	0.9	2.0	5.1	-1.3	1.4	1.7	1.4	0.0	-0.9	-0.7	-0.5	1.6	2.2	1.5	1.3	2.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.7	-0.0	0.7	0.9	0.2	1.3	0.5	0.3	0.5	0.6	1.3	0.6	0.4	0.9
Ulcerative Colitis (UC)	0.7	1.3	4.3	1.4	-0.6	-0.3	-1.1	2.1	1.9	0.9	1.1	-0.6	-0.4	-0.8	-0.9	-0.9
Major Depression (MDD)	0.9	1.2	3.7	-1.4	-0.9	0.1	-0.4	-1.6	0.3	-1.9	-1.8	0.6	-0.4	1.1	-0.4	-0.3
Reaction Time	0.6	1.2	3.1	1.5	0.5	0.6	0.6	1.5	0.5	1.5	1.1	1.8	-0.7	-1.3	0.4	0.9
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.1	-0.6	-1.3	-2.5	-0.9	-0.3	0.3	-1.2	-0.6	-1.7	-1.3	-2.3	-1.8	-0.7
Breast Cancer	2.7	6.6	18.9	1.0	3.9	4.3	1.8	-0.1	0.4	2.1	2.4	2.5	2.4	-0.4	4.1	2.9
Ovarian Cancer	1.3	1.7	6.1	-1.0	1.6	1.1	0.6	-1.6	-1.2	-0.4	-0.2	1.4	1.6	0.4	1.3	2.5
Prostate Cancer	1.1	1.5	6.8	-1.2	0.3	-1.0	-1.6	-2.2	-2.6	-0.9	-0.6	-0.7	0.9	0.0	-0.7	0.6
Age at First Birth	1.3	1.8	6.7	-1.6	1.2	1.2	1.4	-1.2	-0.5	0.2	-0.4	-0.4	2.6	2.3	1.5	0.3
Bipolar Disorder (2011)	5.4	5.2	13.5	-1.8	1.3	2.3	1.4	-2.0	-1.3	-2.2	-2.0	3.6	1.6	3.7	2.6	2.4
Body Mass Index (BMI) (2010)	0.8	1.1	4.4	-1.3	-0.3	-0.9	-1.6	-0.0	2.1	-0.9	-1.5	0.4	0.0	0.4	-0.8	0.2
Coronary Artery Disease (CAD)	0.7	0.8	3.5	0.5	-0.7	-0.2	-0.8	1.2	1.9	-0.2	-0.1	-0.8	-0.9	-0.9	-0.9	-0.9
Crohns Disease (2012)	1.4	2.2	5.1	-1.5	1.5	1.8	1.1	-0.1	-0.7	-0.5	-0.7	1.4	2.3	1.7	1.7	2.2
Mean Putamen Volume	1.7	1.9	8.1	1.1	-0.5	-0.9	-2.4	2.1	0.6	0.6	0.7	-0.1	-0.7	-2.9	-1.7	0.2
Fasting Glucose	0.3	0.3	2.8	-0.3	-0.2	0.4	-0.6	0.8	1.7	-0.4	-0.3	-0.2	0.1	0.2	-0.0	-0.2
HbA1C	1.2	1.3	3.8	-0.3	1.3	-0.6	-0.6	0.9	1.9	0.1	0.2	1.8	1.3	1.2	-0.2	1.9
HDL Cholesterol	1.3	2.1	7.1	0.3	-2.0	-2.7	-0.6	0.4	-0.4	-0.3	-0.1	-2.2	-1.4	-0.8	-2.4	-1.6
LDL Cholesterol	2.2	3.5	8.6	0.0	2.9	2.7	0.8	-0.8	0.4	0.7	0.1	2.6	2.3	1.4	2.9	2.3
Lupus	0.4	0.7	3.6	0.4	0.8	-0.1	-0.9	1.1	-1.9	0.7	0.7	0.0	1.0	-0.0	0.3	0.6
Neuroticism (2016)	0.2	0.3	0.8	0.8	-0.2	-0.4	-0.2	0.1	-0.6	0.6	0.1	-0.9	0.3	0.5	-0.3	-0.7
Primary Biliary Cirrhosis	0.3	0.5	1.8	0.5	0.3	-0.7	-0.1	0.8	-0.8	0.7	1.0	-1.3	0.1	-0.4	-0.7	-0.3
Rheumatoid Arthritis	0.9	1.2	2.9	1.7	-0.3	-0.2	-0.3	1.5	-1.1	1.6	1.5	-1.1	-0.8	-1.3	-0.3	-1.2
Schizophrenia (2014)	0.9	2.0	6.7	-0.9	1.4	1.6	1.3	-0.4	-1.3	0.2	0.0	2.5	1.5	0.6	1.4	2.6
Triglycerides	1.2	1.9	5.5	1.8	1.2	2.3	0.5	1.3	0.4	1.6	1.4	2.3	-0.3	-0.4	1.1	1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	4.0	0.3	0.8	0.1	-0.7	0.4	-2.0	0.3	0.7	-1.0	0.6	-0.7	-0.9	0.3
Ulcerative Colitis	1.4	2.0	4.8	-1.0	-1.8	-2.2	-2.2	0.9	0.6	-1.0	-0.7	-1.5	-0.9	-0.1	-2.2	-1.5
Blood Eosinophil Count	0.3	2.0	6.6	-0.5	-2.6	-1.0	0.7	0.5	1.4	-0.9	-0.7	-0.4	-2.1	0.9	-2.1	-2.0
Blood Platelet Count	0.8	8.8	25.1	5.0	2.1	2.0	1.1	3.2	2.7	4.4	4.7	1.1	-0.5	-4.1	0.9	1.5
Blood Red Count	0.4	4.2	13.9	3.0	0.6	1.9	0.6	3.7	-0.0	3.3	3.5	0.4	-0.8	-1.6	-0.0	0.7
Blood White Count	2.1	15.6	46.1	6.8	-1.1	-0.1	0.6	6.0	1.7	4.6	5.8	-0.2	-3.9	-6.1	-2.4	-1.6
Heel T-Score	1.1	8.4	24.5	3.9	1.0	3.1	0.8	4.5	2.6	5.0	4.8	0.5	-1.2	-2.1	0.3	1.1
BMI	0.3	1.7	9.2	-3.0	-0.2	-1.5	0.1	-0.7	0.3	-1.4	-0.8	0.3	1.4	1.5	-1.4	1.2
Height	0.4	7.0	19.8	2.9	-1.5	-2.7	-0.7	3.1	-4.4	1.4	2.5	-2.8	-1.4	-3.0	-3.1	-2.5
Waist Hip Ratio (WHR)	0.3	1.2	4.9	-0.1	-0.2	-1.1	-1.0	0.6	-2.2	-0.2	0.9	-1.1	0.2	-2.2	-1.2	-0.1
Systolic Blood Pressure	0.3	1.6	4.8	1.5	-2.0	-1.3	-0.4	1.4	0.8	0.4	-0.3	-0.9	-1.7	0.3	-1.1	-2.2
Smoking Status	0.8	1.8	5.4	-1.1	-1.3	-0.5	-1.1	-1.6	-1.2	-1.6	-2.1	-0.7	-0.5	2.3	-0.1	-1.4
Allergy or Eczema	0.3	0.8	2.7	-1.6	0.3	-0.1	-0.4	-1.2	-1.6	-1.3	-0.7	-0.0	0.6	0.6	0.5	0.5
Cardiovascular Disease	0.1	0.4	3.0	0.1	-0.6	-0.9	-0.2	0.3	-0.1	-0.2	-0.7	0.5	-0.1	1.7	-0.2	-0.7
Hypothyroidism (self reported)	0.1	0.3	0.7	0.4	-0.5	0.7	-0.5	0.2	0.3	0.1	-0.2	0.6	-0.8	0.4	0.4	-0.8
Respiratory disease	0.2	0.5	1.1	-0.8	-0.9	0.9	1.0	-0.4	0.4	-1.0	0.0	0.7	-1.0	-0.2	0.1	0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.6	0.4	0.1	0.6	-0.1	1.4	0.4	0.3	0.9	0.9	-0.3	-1.6	-0.2	1.3
Lung FEV1/FVC ratio	0.1	0.5	3.8	-0.7	-0.2	-0.2	0.3	-0.1	0.3	0.2	0.9	-2.0	0.5	-0.1	-0.6	-0.8
Lung FVC	0.3	1.7	5.0	0.6	1.4	1.6	2.2	-1.6	0.2	1.2	-0.4	0.0	1.1	1.5	2.2	-0.2
Neuroticism	0.6	1.4	4.1	0.9	-2.0	-1.0	-0.8	-0.4	0.1	-1.3	-1.1	0.2	-2.0	-0.5	-1.1	-1.7
Chronotype (morning person)	1.0	2.2	4.7	1.0	1.0	0.9	2.0	2.2	1.4	1.6	2.0	2.0	1.0	0.3	0.6	1.7
Hair Pigment	0.0	1.1	5.3	1.3	0.1	0.4	-0.7	2.3	0.4	1.3	1.3	1.2	0.0	-0.7	0.0	1.0
Tanning	0.1	1.4	5.3	-1.6	0.4	0.9	0.3	-0.7	0.2	-1.4	-1.2	1.7	0.9	1.0	0.5	2.3
Hand grip strength (left)	0.8	2.1	4.1	0.3	1.8	2.0	1.4	0.6	1.5	1.9	2.0	-0.4	1.8	1.1	1.5	1.1
Number of treatments/medications taken	0.3	0.5	2.0	-0.5	-0.6	-0.4	0.8	-0.6	0.5	-1.4	-0.7	1.3	-0.6	-0.1	-0.2	0.5
Average weekly spirits intake	0.6	0.7	3.2	0.2	0.2	1.3	1.7	0.4	1.8	0.1	0.3	-0.1	0.4	0.3	0.6	-0.2
Sensitivity / hurt feelings	0.7	1.2	3.0	0.4	-1.3	-1.6	-0.7	0.5	1.2	-1.0	-0.2	0.3	-1.6	-1.3	-1.7	-0.4
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.8	0.5	-0.4	-0.2	-0.0	-0.8	-0.4	-0.4	-0.4	0.4	-0.5	0.1	-0.0	-0.9
Hearing difficulty/problems: Yes	0.5	0.8	1.9	-1.4	0.4	-0.9	-0.6	-0.9	-1.2	-1.0	-1.1	0.2	0.7	1.3	0.1	0.4
Relative age of first facial hair	2.1	4.3	9.3	2.3	-1.7	-2.0	-1.2	1.1	-1.8	1.8	1.8	-3.0	-2.6	-2.1	-2.1	-2.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.2	1.1	-0.2	-0.2	0.8	0.6	-0.3	0.3	-0.1	1.5	-1.0	-0.3	0.3	0.6
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.7	1.1	-0.7	0.8	0.3	1.1	1.1	0.9	1.0	-0.4	-1.1	-0.4	-0.2	-1.3
Ever had hysterectomy (womb removed)	0.7	0.7	2.8	0.4	-0.6	0.0	1.4	0.7	0.6	0.3	1.7	-0.7	-1.0	-1.0	-0.6	-0.7
Systolic blood pressure, automated reading	0.3	0.8	1.8	0.8	-1.1	-1.0	-1.2	1.3	-0.1	0.3	0.0	-0.9	-0.8	-0.7	-1.2	-1.0
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	4.7	1.5	1.0	1.9	2.0	0.8	-0.7	1.1	1.2	2.2	-0.4	-0.7	1.4	0.8
Angina	0.8	1.1	5.5	0.7	0.7	0.7	0.9	1.1	-1.5	0.7	0.6	2.3	0.2	-0.0	0.7	1.2
Medication for hormone replacement therapy	0.2	0.2	0.7	0.3	-0.2	0.5	0.4	-0.1	0.8	-0.1	0.3	0.5	-0.5	-0.1	0.3	-0.5
Vitamin and mineral supplements	0.5	0.7	5.4	0.2	-0.4	-1.1	-0.5	0.8	-2.3	0.2	0.4	-0.1	-0.4	-0.2	-0.8	-0.2
Supplements: Zinc	0.6	0.6	3.7	-0.3	-0.2	-0.7	-0.4	0.5	1.9	-0.1	0.0	-1.5	0.1	-0.6	-0.2	-0.7
Medication: Co-codamol	0.4	0.5	1.6	-0.3	1.3	0.1	0.3	-0.7	-0.4	-0.1	0.4	0.5	1.2	-0.1	1.2	0.8
Medication: Metformin	1.2	1.6	4.0	0.4	1.6	1.7	1.2	1.1	0.5	0.4	1.1	1.7	1.1	-0.9	1.5	2.0
Diabetes (father)	2.1	2.6	7.1	2.7	-0.3	1.3	1.1	2.5	0.5	2.5	2.5	-0.5	-1.5	-1.2	-0.6	-0.7
Diabetes (mother)	1.3	1.7	5.5	1.0	-0.6	-0.9	-0.1	0.9	1.0	1.1	1.9	-2.3	-0.7	-2.1	-1.3	-1.0
Severe depression (siblings)	1.3	1.5	4.9	-0.9	0.4	0.9	0.6	-2.0	-2.2	-0.4	-1.5	1.0	1.1	1.0	1.6	0.5
Pack years adult smoking proportion	1.4	2.1	6.8	0.6	-2.3	-1.8	-0.8	0.3	0.6	-1.0	-1.3	-0.9	-1.5	1.8	-1.0	-2.6
Impedance of leg (right)	0.4	2.1	9.3	2.5	-1.3	0.7	0.2	1.3	0.3	1.8	1.1	-0.6	-3.1	-1.2	-0.6	-1.2
Leg fat-free mass (left)	0.2	1.3	4.3	-1.9	0.6	-1.5	-0.2	-0.2	-1.8	-1.0	-0.4	-0.1	2.1	0.9	-0.6	0.5
Trunk fat percentage	0.5	1.9	8.4	-2.9	-0.1	-1.3	-0.6	-0.9	-0.7	-2.1	-1.8	0.3	0.8	1.2	-1.2	1.0
Hand grip strength (right)	1.1	3.1	9.2	0.4	2.6	2.2	0.8	1.1	1.2	1.6	3.0	-0.1	2.3	-0.9	1.4	2.2
Townsend deprivation index at recruitment	0.7	1.0	3.4	-1.5	-0.2	-0.5	-0.1	-1.5	-0.9	-0.9	-1.4	-0.1	0.9	1.8	0.2	-0.0
Current tobacco smoking	0.7	1.1	4.9	-1.3	-1.0	-0.2	-0.7	-0.2	-0.8	-1.2	-1.8	-0.8	-0.2	2.2	-0.0	-0.9
Average weekly fortified wine intake	0.6	0.8	2.2	1.4	0.6	0.5	-0.2	1.5	-0.4	1.5	1.2	0.0	0.3	-0.8	0.6	0.2
Maternal smoking around birth	0.8	1.2	5.9	-0.7	1.2	0.3	0.8	-0.0	1.5	0.5	-0.3	-0.0	1.6	2.4	1.2	0.5
Fed-up feelings	0.6	1.1	5.1	0.9	-1.1	-0.7	-1.5	0.1	-0.5	-0.2	-0.5	-0.5	-0.6	1.9	-0.2	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.3	1.7	-1.2	-0.5	0.2	-0.1	-1.4	0.2	0.1	-0.1	-1.8	-0.8	-0.5	-1.7
Relative age voice broke	1.0	1.5	4.2	1.7	-0.2	0.2	-0.1	0.7	-1.2	1.9	1.9	-2.0	-0.8	-1.1	-0.2	-1.2
Taking other prescription medications	0.4	0.7	1.6	-0.6	-0.9	-0.4	1.3	-1.3	-0.4	-1.2	-0.8	0.8	-0.8	0.7	0.1	-0.5
Age when periods started (menarche)	1.3	3.2	12.7	1.5	-2.3	-1.4	-2.2	-0.1	0.0	-0.1	-0.4	-2.2	-2.6	-0.4	-1.7	-3.6
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.2	0.0	-1.8	-0.6	-0.5	0.6	0.8	-0.5	-0.1	-0.4	-1.6	0.3	-1.0	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.4	8.9	0.8	1.0	2.2	0.8	1.9	1.1	2.3	3.0	-0.0	-0.1	-1.6	0.3	1.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.5	-0.4	-0.6	-1.8	-1.9	-0.6	0.7	-0.2	-0.7	-1.7	-0.2	0.2	-1.3	-0.9
Qualifications: CSEs or equivalent	1.6	2.1	6.2	-0.1	-2.5	-2.0	0.2	0.2	-1.3	-1.6	-0.4	-1.0	-2.1	-0.0	-1.7	-2.0
Serious illness, injury or assault to yourself	0.9	1.1	4.9	0.9	1.1	0.9	-0.1	0.6	0.5	0.7	1.4	1.1	0.3	-2.2	0.1	1.5
High blood pressure	0.2	0.4	1.0	0.1	-1.0	-0.8	-0.5	0.7	-0.6	-0.3	-0.7	-0.3	-0.7	0.6	-0.7	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-0.9	0.1	-0.2	-0.6	-0.1	-0.9	-1.0	-0.4	0.9	0.4	0.6	0.4	0.9
Multivitamins +/- minerals	0.5	0.7	4.0	0.9	0.1	0.2	0.3	0.8	2.0	0.8	0.7	-0.6	-0.4	-1.1	-0.1	0.1
Stomach or abdominal pain in last month	1.1	1.4	2.8	1.4	-0.9	-1.4	0.0	1.4	0.1	0.7	1.7	-1.4	-1.2	-1.6	-0.8	-1.5
Supplements: Glucosamine	0.8	1.1	4.9	1.0	0.9	0.2	2.2	0.8	-0.1	0.8	1.9	-0.1	0.3	-1.5	0.3	0.6
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	9.1	1.0	-0.4	-1.2	-1.4	2.1	3.0	1.3	1.4	-1.0	-0.4	-1.1	-1.4	-0.2
Medication: Atenolol	0.7	0.9	3.4	-1.1	1.0	0.2	-0.2	-0.2	-1.8	-0.1	-0.3	1.2	1.3	0.4	0.4	1.7
Medication: Levothyroxine sodium	0.5	0.8	3.0	-1.0	-1.0	-0.2	-0.4	-0.9	-0.6	-0.9	-1.5	0.3	-0.4	1.7	-0.3	-0.4
Sitting height	0.2	1.5	6.6	-1.4	-0.3	-0.9	-0.5	-0.6	-2.6	-0.0	-0.3	-2.3	0.9	1.0	-0.5	-1.3
Chronic bronchitis/emphysema (father)	0.7	0.9	5.8	-0.4	-0.5	0.1	-0.7	-0.2	1.1	-0.4	-1.5	0.7	0.1	2.4	0.2	-0.4
High blood pressure (mother)	0.3	0.4	1.4	1.0	-0.2	0.5	1.2	0.9	0.6	0.9	0.8	0.2	0.1	0.1	0.3	-0.4
Body mass index (BMI)	0.6	2.6	11.7	-3.4	1.0	-0.4	0.7	-1.0	-0.3	-1.6	-1.0	1.1	2.5	1.9	-0.1	2.3
Impedance of leg (left)	0.4	1.9	8.6	2.5	-1.2	0.9	0.1	1.4	-0.3	1.6	0.9	-0.2	-2.9	-1.0	-0.5	-0.9
Leg predicted mass (left)	0.3	1.4	4.5	-2.0	0.6	-1.5	-0.2	-0.3	-1.9	-1.1	-0.5	-0.2	2.1	1.0	-0.6	0.5
Trunk fat mass	0.4	1.6	7.3	-2.7	0.3	-1.2	-0.1	-0.4	-1.2	-1.7	-1.1	0.5	1.4	1.2	-1.0	1.3
Waist circumference	0.6	2.3	7.5	-2.7	0.9	-0.7	0.7	-0.8	-2.6	-1.3	-0.6	1.0	2.0	1.4	-0.1	2.0
Number of incorrect matches in round	0.3	0.4	1.2	1.1	-0.7	1.0	-0.0	0.7	-0.1	0.4	-0.1	0.4	-0.9	0.4	0.3	-1.0
Past tobacco smoking	0.5	0.9	3.3	0.2	1.2	0.2	1.2	0.5	0.3	1.0	1.3	-0.2	1.0	-1.8	-0.1	1.3
Alcohol usually taken with meals	0.9	1.4	8.4	1.3	-0.2	-0.5	-0.5	1.3	-0.5	1.0	1.4	-0.0	-1.0	-2.9	-1.3	0.5
Nervous feelings	0.5	1.0	2.0	0.5	-1.3	-1.4	-1.2	-1.2	-0.1	-1.3	-1.4	0.5	-1.3	0.3	-0.9	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.5	1.0	-1.4	-0.3	0.1	0.1	0.6	-0.5	-0.2	0.6	-1.6	-0.6	-0.7	-0.6
Hearing difficulty/problems with background noise	0.6	1.0	3.1	-1.8	-0.5	-1.0	-0.5	-0.3	-1.1	-1.3	-1.6	0.5	-0.0	1.1	-0.8	0.6
Hair/balding pattern: Pattern 2	0.9	1.1	3.3	-1.8	0.0	-1.4	-0.3	-1.8	-0.7	-1.1	-0.6	-1.0	0.4	-1.0	-0.8	1.0
Had menopause	0.8	1.0	3.5	-0.5	1.0	0.6	0.8	-1.5	-1.9	-1.0	-0.8	1.1	0.6	-0.0	1.2	0.9
Had other major operations	0.7	0.8	3.2	-0.9	0.3	1.8	0.5	-1.7	-0.8	-0.6	-0.4	0.9	-0.1	-0.1	1.3	0.4
Forced vital capacity (FVC)	0.3	1.1	3.3	1.3	-0.6	-1.2	-0.3	0.7	-1.1	1.2	0.6	-1.8	-0.4	-0.0	-0.5	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	9.0	0.7	1.1	2.6	1.2	2.3	1.9	2.3	3.0	0.2	0.3	-1.3	0.5	1.5
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	6.6	-1.8	0.2	-1.5	-0.6	-2.4	-1.8	-2.6	-1.7	0.6	0.5	-0.0	0.3	0.7
Qualifications: None of the above	0.6	1.3	4.6	-0.8	1.2	0.1	-0.3	-1.3	0.8	-0.4	-1.2	1.0	1.7	2.1	1.3	0.9
Financial difficulties in last 2 years	0.9	1.3	4.1	1.8	-1.1	0.0	-0.1	0.9	-0.9	1.2	1.0	-1.3	-1.1	-0.3	-0.8	-2.0
Mouth/teeth dental problems	0.4	0.6	1.8	-1.1	-1.2	-0.1	-0.9	-0.2	-0.2	-1.2	-0.8	-0.1	-0.6	0.2	-1.4	0.0
Heart attack	0.5	0.6	1.5	1.0	0.9	0.6	0.1	0.6	-0.9	1.2	1.2	1.0	0.3	0.3	0.7	0.7
Allergy	0.3	0.7	2.7	0.8	-0.9	-0.7	-0.1	0.3	-0.3	0.2	-0.3	-1.2	-0.9	-0.8	-1.2	-1.6
Pain all over the body in last month	0.6	0.6	2.1	1.1	0.5	0.7	1.4	0.5	-0.3	0.7	1.0	0.9	-0.3	-0.5	0.9	0.2
Diabetes (self-reported)	0.4	0.6	4.7	0.5	-0.2	0.7	-0.1	0.6	-0.3	-0.6	0.2	1.0	-0.5	-2.2	-0.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.5	-0.8	-1.4	-1.6	0.2	-0.9	0.8	-0.9	-1.4	-0.6	-1.0	0.2	-1.1	-0.6
Medication: Ramipril	0.7	0.9	3.4	1.9	-0.4	-0.3	0.8	1.4	0.0	1.4	1.3	0.2	-0.8	-0.2	-0.9	-0.4
Medication: Simvastatin	0.8	1.2	5.1	0.6	1.0	0.6	1.2	-1.0	-2.3	-0.3	-0.1	1.8	0.3	0.5	1.5	0.6
Fluid intelligence score	1.5	3.0	11.6	0.1	-1.6	-2.3	-1.3	0.1	1.2	0.1	0.3	-2.9	-1.6	-3.4	-2.3	-0.9
Illnesses of siblings	1.5	2.1	4.7	1.2	-1.4	-1.7	0.3	1.6	-0.4	0.8	0.8	-2.2	-1.2	-2.1	-1.9	-1.6
Neuroticism score	0.4	0.8	2.3	1.3	-1.4	-0.5	-0.5	-0.4	0.7	-0.7	-0.4	0.5	-1.5	-0.0	-0.4	-1.4
Weight	0.3	1.7	5.7	-2.4	0.7	-1.1	0.4	-0.1	-2.2	-0.9	-0.2	0.4	2.0	1.1	-0.7	1.4
Impedance of arm (right)	0.5	2.3	6.9	1.2	-1.8	-1.5	-2.0	0.1	-0.4	-0.2	-1.0	-1.5	-2.6	-0.6	-1.5	-2.5
Arm fat percentage (right)	0.5	2.1	10.3	-3.2	-0.1	-1.5	-0.3	-0.9	-0.3	-2.1	-1.7	-0.0	1.2	1.5	-1.2	1.1
Trunk fat-free mass	0.2	1.4	7.0	-0.1	0.9	-0.2	0.6	1.4	-2.6	0.9	1.8	0.1	1.7	0.0	-0.2	1.0
Hip circumference	0.5	2.2	6.2	-2.5	0.9	-0.5	0.9	-0.9	-2.1	-0.9	-1.0	1.0	2.0	2.4	0.1	1.7
Time employed in main current job	1.1	1.2	7.3	0.9	0.5	-0.4	-0.7	1.7	1.5	0.5	1.0	0.0	0.0	-2.7	-0.5	0.7
Alcohol intake versus 10 years previously	0.8	1.2	3.7	0.2	1.1	1.6	0.8	-0.7	-0.3	0.2	0.4	1.9	0.7	1.2	1.6	1.4
Father’s age at death	0.5	0.7	3.5	-0.4	1.4	1.0	-0.4	-0.2	-0.7	0.3	0.2	0.4	1.0	-0.3	0.7	1.9
Worrier / anxious feelings	0.1	0.2	0.6	0.0	-0.2	-0.5	-0.2	0.1	0.6	-0.7	-0.6	0.8	-0.0	0.4	0.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.2	1.5	-0.2	-0.2	0.8	1.2	1.1	0.3	0.4	0.4	0.0	0.2	0.1	-0.3
Falls in the last year	0.3	0.4	2.4	-1.5	0.3	-0.4	-0.5	-1.0	0.2	-0.6	0.1	-0.0	0.3	-0.1	-0.5	0.9
Hair/balding pattern: Pattern 3	1.7	2.6	7.0	1.3	-2.0	-1.0	-0.1	2.6	1.3	0.8	0.9	-0.7	-2.3	-1.3	-2.1	-2.2
Number of live births	0.6	0.8	2.1	1.1	0.9	1.1	0.8	-0.2	-0.7	1.3	1.4	-0.3	-0.1	-1.4	0.7	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	5.5	0.8	-0.7	-1.3	0.0	0.3	-0.7	0.9	0.9	-2.3	-0.5	-0.5	-0.7	-1.8
Pulse rate	0.6	1.0	2.3	0.5	-1.3	-1.5	-1.2	0.1	-0.3	-0.9	-0.3	-1.1	-1.1	-0.8	-1.5	-1.3
Happiness	0.4	0.5	1.8	0.6	-0.0	-0.3	0.9	-1.3	-0.5	-1.0	-0.0	-0.2	-0.2	-0.5	0.7	-1.3
Noisy workplace	0.7	0.8	2.5	-0.9	-0.1	0.8	-0.1	-0.8	0.5	-1.6	-1.5	0.9	0.5	1.5	0.7	0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.9	-0.4	1.1	0.5	0.1	-0.4	-1.7	1.0	0.4	-0.8	0.9	-1.1	0.8	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	4.5	0.7	-1.1	-0.7	-0.4	0.9	-1.1	0.8	1.3	-1.6	-1.7	-2.1	-1.2	-0.8
Mouth/teeth dental problems: Dentures	1.2	2.0	4.4	1.9	2.1	1.2	0.8	1.0	-0.2	1.9	2.0	1.2	1.0	-0.7	1.9	1.0
Asthma	0.2	0.5	1.8	0.1	0.2	0.7	1.1	0.7	0.3	0.0	1.3	0.8	-0.1	-0.6	0.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	3.0	-0.3	-0.9	-1.6	-1.7	-0.2	0.2	-1.4	-1.0	-0.1	-0.5	-0.6	-0.8	-0.6
Medication: Cholesterol lowering	1.1	1.7	4.5	0.3	1.5	1.2	1.8	-0.9	-1.3	0.4	0.1	2.1	1.0	1.6	1.9	1.1
Depression (self-reported)	3.4	4.1	9.4	-2.3	-2.5	-1.8	-1.1	-3.0	-1.4	-2.1	-3.1	-1.6	-1.2	1.8	-1.2	-1.9
Medication: Lansoprazole	1.4	1.6	4.2	0.2	-1.9	-1.1	-0.3	-0.5	0.4	-2.0	-1.2	-0.1	-1.9	0.6	-1.1	-2.0
Prospective memory result	0.8	1.0	3.4	0.8	1.6	0.7	1.9	0.1	0.3	0.5	0.8	0.7	1.3	-0.1	0.9	1.4
Lung cancer (father)	0.5	0.6	2.6	0.2	0.7	0.6	1.0	0.4	-0.5	0.8	0.3	1.6	0.5	-0.1	0.8	1.0
Illnesses of mother	1.0	1.2	4.0	-1.1	-0.1	-0.5	-1.2	-2.0	-1.8	-1.4	-1.7	0.0	-0.0	0.2	0.0	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	4.2	-0.0	-0.3	-1.3	0.3	-0.3	-1.4	0.3	0.1	-2.0	0.1	0.4	-0.3	-1.4
Pulse wave Arterial Stiffness index	1.7	2.0	6.4	0.7	-0.6	-0.3	-0.6	1.4	-1.0	1.3	2.2	-2.1	-0.9	-2.5	-1.7	-1.1
Impedance of arm (left)	0.5	2.3	6.1	1.2	-1.5	-1.5	-2.2	-0.0	0.4	-0.3	-1.1	-1.6	-2.5	-0.8	-1.4	-2.4
Arm fat mass (right)	0.4	1.7	8.9	-3.0	0.6	-1.0	0.3	-0.4	-0.9	-1.4	-0.7	0.4	1.9	1.2	-0.7	1.8
Trunk predicted mass	0.2	1.4	7.0	-0.1	0.9	-0.3	0.5	1.4	-2.6	0.9	1.8	0.0	1.8	0.1	-0.2	1.0
Standing height	0.4	3.9	19.5	1.9	-0.6	-1.7	-0.7	2.1	-4.4	1.5	2.1	-1.9	-0.7	-1.8	-1.7	-1.8
Length of working week for main job	0.4	0.5	2.2	-0.4	-0.5	-0.4	-0.7	-0.2	1.5	-0.3	0.0	-0.7	-0.4	0.5	-0.3	-1.2
Exposure to tobacco smoke at home	0.1	0.2	0.5	0.2	-0.5	0.2	-0.3	0.6	-0.3	-0.0	0.7	0.2	-0.4	-0.3	-0.6	-0.0
Breastfed as a baby	0.7	0.9	3.3	1.0	1.1	0.8	0.6	1.3	-0.4	1.0	1.8	0.7	0.8	0.5	0.8	0.5
Tense / ‘highly strung’	0.8	1.4	3.6	0.4	-1.9	-0.8	-0.3	-1.2	0.1	-1.8	-1.8	0.2	-1.4	1.0	-0.6	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.1	-1.1	-1.3	-0.9	-0.5	-1.1	0.5	-1.4	-1.8	-0.4	-0.8	0.8	-0.4	-1.1
Hair/balding pattern: Pattern 4	0.2	0.5	1.6	1.1	0.5	1.3	0.3	0.4	-0.4	0.7	0.4	1.2	0.0	-0.3	0.8	0.1
Birth weight of first child	0.2	0.3	1.0	-1.0	-0.5	-0.6	0.9	-0.2	0.1	-1.0	-0.6	0.3	-0.4	0.1	-0.5	0.4
Peak expiratory flow (PEF)	0.4	0.9	3.8	-0.0	-1.2	-0.9	0.9	0.2	1.1	-0.2	0.4	-2.0	-0.4	0.2	-0.6	-1.6
Pulse wave reflection index	0.4	0.4	1.4	-0.6	0.2	0.4	-0.8	0.7	0.8	1.0	1.2	-0.7	-0.2	-0.6	-0.1	0.3
Ever highly irritable/argumentative for 2 days	1.6	2.0	4.3	2.0	0.1	-0.5	-1.2	1.5	0.9	1.8	1.8	-2.1	-0.8	-1.7	-0.8	-1.3
Loud music exposure frequency	0.9	1.0	2.9	-1.3	-1.3	-1.7	-0.2	0.0	0.3	-0.9	-0.8	-1.3	-0.3	0.2	-1.5	-0.8
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.7	0.8	0.3	-0.1	1.2	0.8	-2.4	1.3	1.7	-2.0	-0.1	-2.3	-0.4	-0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	3.0	0.3	-1.0	-1.3	-0.1	-0.4	0.3	-0.6	-1.7	-0.5	-0.9	0.9	0.1	-1.1
Blood clot in the leg (DVT)	0.4	0.5	2.3	-0.8	0.5	-0.2	-0.2	-0.4	0.7	0.4	0.3	-1.5	1.3	0.3	-0.3	-0.2
Medication: Paracetamol	1.4	2.4	7.7	0.5	-2.5	-2.8	-0.4	0.5	0.2	-1.1	-0.7	-0.7	-2.4	-1.1	-2.2	-1.6
Headache pain in last month	1.0	1.7	4.9	1.6	-1.6	-1.8	-0.8	0.4	0.5	0.5	0.6	-1.4	-1.6	-0.8	-1.5	-2.2
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.4	-0.4	-1.3	-0.9	-1.4	1.0	1.0	0.4	0.7	-2.1	-1.1	-2.0	-2.0	-0.8
Glaucoma (self-reported)	0.3	0.3	1.0	-1.0	0.3	0.3	1.0	-0.9	0.6	-0.7	-0.2	0.4	0.0	-0.1	0.0	0.3
Gout (self-reported)	1.1	1.5	3.5	0.5	1.9	1.5	1.7	0.5	-0.8	0.9	1.4	0.6	1.5	-0.7	1.7	1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	2.0	0.3	-0.5	0.6	-0.2	-0.4	-0.1	0.0	-1.0	0.8	-0.4	1.4	0.6	-0.6
Medication: Amlodipine	0.7	0.9	4.1	0.3	0.0	0.4	1.2	-0.8	-0.7	-0.6	-1.0	1.3	0.1	2.0	1.3	-0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.6	0.6	-0.4	0.7	-0.6	0.3	-1.6	1.0	0.5	0.5	-0.5	-0.1	-0.3	-0.1
Birth weight	1.1	2.3	7.6	-1.6	-1.0	-1.8	-0.8	-2.5	-0.7	-2.7	-2.7	0.6	-0.7	-0.1	-0.5	-0.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	2.5	-0.0	0.1	0.6	-1.6	-0.4	-0.3	0.6	-0.3	-0.0	0.2	0.5	-0.1	-0.1
High blood pressure (siblings)	1.4	2.0	5.4	-1.5	1.3	0.7	-0.9	-1.7	-0.2	-1.3	-1.3	1.5	1.6	2.3	1.2	1.5
Forced vital capacity (FVC), Best measure	0.3	1.0	3.4	0.5	-0.4	-1.3	-0.1	-0.4	-1.7	0.5	-0.3	-1.8	-0.2	0.9	-0.3	-1.8
Body fat percentage	0.4	1.7	8.6	-2.9	0.3	-0.9	-0.0	-0.8	-0.5	-1.8	-1.4	0.6	1.2	1.4	-0.8	1.6
Leg fat percentage (right)	0.5	1.9	7.4	-2.7	1.1	0.3	0.9	-0.6	0.1	-0.8	-0.5	1.3	1.7	1.5	0.1	2.7
Arm fat-free mass (right)	0.2	1.1	3.9	-0.5	1.0	-0.0	0.9	1.0	-2.0	0.6	1.5	0.2	1.8	0.0	-0.1	1.2
Exposure to tobacco smoke outside home	0.4	0.5	1.4	0.2	-0.8	-0.2	-1.1	0.9	-1.2	0.1	0.3	0.1	-0.7	-0.9	-1.1	-0.1
Comparative body size at age 10	1.0	2.6	7.2	-0.8	1.9	2.1	2.1	-0.6	0.1	0.4	0.5	2.7	1.9	0.6	2.1	2.4
Number of full brothers	1.2	1.5	5.6	0.0	1.3	0.1	-0.7	0.7	-0.2	2.4	1.3	-1.1	2.0	1.6	1.1	-0.2
Worry too long after embarrassment	0.6	1.0	4.7	-0.3	-0.5	-0.2	-0.7	-1.3	2.2	-1.4	-1.4	0.2	-0.4	0.7	0.4	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.4	-0.7	-1.5	-0.4	-1.3	-0.3	-0.7	-1.4	-1.5	0.4	-1.2	-0.3	-0.5	-0.5
Wheeze or whistling in the chest in last year	0.6	1.1	3.2	0.4	-1.8	-0.7	-0.5	1.4	1.1	-0.7	0.5	0.7	-1.6	-0.2	-1.8	0.2
Number of children fathered	0.6	0.7	2.4	-1.2	-0.5	-1.5	0.3	0.7	0.9	-0.4	0.5	-0.3	-0.2	-0.7	-1.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.9	-0.4	0.8	0.6	0.8	1.0	-0.1	0.6	1.2	1.1	0.8	0.0	0.2	2.0
Age at first live birth	0.5	0.9	3.1	0.5	-0.5	-0.6	-0.5	0.1	-1.2	0.3	-0.0	-1.3	-0.6	-1.7	-0.6	-1.8
Pulse wave peak to peak time	1.3	1.5	5.7	-0.4	0.6	0.3	0.6	-1.1	0.9	-1.0	-1.9	1.9	0.8	2.4	1.4	0.9
Health satisfaction	0.9	1.2	4.0	0.5	-1.6	-1.0	-0.7	-0.3	0.7	-1.3	-0.7	-0.2	-1.7	-0.7	-1.2	-2.0
Shortness of breath walking on level ground	2.3	2.7	6.7	-0.3	-2.5	-2.6	-1.1	0.5	0.5	-1.9	-1.1	-0.8	-2.2	-0.8	-2.6	-1.7
Qualifications: College or University degree	0.5	1.7	5.9	1.4	1.2	1.1	-0.1	0.0	-1.8	2.0	1.8	-0.9	0.0	-2.4	0.5	0.1
Eye problems/disorders: None of the above	0.4	0.4	1.2	0.3	0.6	1.0	0.6	0.0	-1.1	0.6	0.2	0.1	1.0	-0.4	0.9	0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.3	0.5	-1.0	-0.7	-0.4	0.1	-0.9	0.2	-0.6	-0.6	-0.9	0.4	-0.3	-1.1
Emphysema/chronic bronchitis	0.8	0.9	3.2	0.6	0.2	1.8	0.1	0.1	1.8	0.6	0.4	1.0	-0.1	1.5	1.2	-0.1
Medication for pain relief, constipation, heartburn	1.2	2.0	6.1	-1.4	2.2	1.7	-0.4	-1.8	-0.3	0.7	0.1	-1.0	2.5	1.3	1.9	0.7
Neck or shoulder pain in last month	0.5	0.6	2.7	1.0	0.1	-0.1	-1.6	0.6	0.7	1.1	1.3	0.4	-0.4	-0.9	-0.1	0.2
Medication: Blood pressure	0.7	1.3	4.0	0.1	0.9	0.9	1.8	-0.8	-0.0	-0.4	-0.8	1.6	0.9	2.0	1.6	0.7
Angina (self-reported)	0.6	0.8	4.1	0.8	0.5	0.4	0.7	1.3	-1.2	0.8	0.5	2.0	0.1	0.1	0.5	0.9
Migraine (self-reported)	1.7	2.1	5.6	0.1	-1.5	-1.6	-0.5	0.7	1.4	0.1	0.8	-2.4	-1.6	-2.2	-2.2	-1.3
Medication: Ibuprofen	0.8	0.9	2.2	-0.1	-1.2	-1.5	-1.5	-0.4	0.4	-1.4	-1.3	0.4	-1.0	-0.2	-0.9	-0.6
Medication: Allopurinol	0.4	0.6	2.5	-0.3	0.7	0.4	1.6	0.1	-0.9	-0.5	0.1	1.2	0.7	-0.3	0.6	0.8
Medication: Omeprazole	0.7	0.8	2.7	1.0	-1.1	-0.5	0.7	1.7	0.9	0.3	0.2	0.9	-1.4	0.4	-0.9	-0.4
Medication: Seretide 50 evohaler	2.7	3.2	6.8	-2.6	-2.2	-2.2	-1.4	-0.9	-0.7	-2.1	-1.4	-2.3	-0.8	0.2	-2.6	-1.6
Mean time to correctly identify matches	0.8	1.4	4.2	1.6	0.9	1.1	-0.1	1.6	0.8	1.4	0.9	2.1	-0.4	-1.7	0.4	1.0
Heart disease (mother)	0.7	0.8	3.3	1.4	1.1	-0.2	1.8	0.9	-0.1	0.9	1.0	-0.2	0.7	-0.7	1.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.5	-0.2	-0.6	-1.4	-1.4	-0.8	0.5	-0.2	-0.6	-1.4	-0.4	0.4	-0.7	-1.6
Whole body fat mass	0.4	1.8	8.9	-3.0	0.5	-0.9	0.4	-0.5	-1.1	-1.6	-0.9	0.6	1.6	1.2	-0.8	1.7
Leg fat mass (right)	0.5	2.0	8.2	-2.9	1.0	-0.3	1.0	-0.5	-0.6	-1.2	-0.7	1.2	1.9	1.4	-0.1	2.3
Arm predicted mass (right)	0.2	1.1	4.6	-0.4	1.0	-0.0	0.5	1.1	-2.1	0.6	1.4	0.3	1.9	-0.1	-0.1	1.2
Pulse rate, automated reading	1.2	3.9	12.9	0.3	-2.5	-3.6	-2.6	0.5	0.0	-0.9	-0.8	-2.1	-2.1	-0.6	-2.4	-2.9
Alcohol intake frequency.	1.9	4.4	9.6	-2.4	1.6	0.7	1.2	-2.1	-0.9	-2.1	-2.2	3.1	2.0	3.0	2.0	2.3
Comparative height size at age 10	0.3	1.7	11.0	0.2	-0.2	-1.6	-0.1	2.0	-3.3	0.2	1.3	-0.6	0.1	-1.1	-1.2	-0.2
Number of full sisters	2.6	3.1	8.1	0.3	-2.0	-2.8	-1.2	-0.9	-2.9	-1.5	-1.3	-2.1	-1.3	0.1	-1.7	-2.4
Suffer from ‘nerves’	0.2	0.3	1.4	-0.2	0.4	-0.0	-0.1	-1.2	0.1	-0.4	-0.5	0.8	0.7	0.1	0.3	1.1
Overall health rating	0.5	1.0	3.8	0.3	-1.4	-1.9	0.8	0.6	-0.5	-1.0	0.4	0.7	-1.4	0.2	-1.6	-0.6
Chest pain or discomfort	0.5	0.7	2.8	0.5	0.2	0.0	1.3	1.3	-0.0	1.4	1.7	-0.3	-0.1	0.1	-0.3	-0.0
Had major operations	0.3	0.4	1.4	1.1	-0.2	-1.1	0.5	-0.1	-0.2	-0.1	-0.2	1.2	-0.5	0.7	-0.3	-0.0
Age at last live birth	0.6	0.9	5.2	0.3	-1.1	-0.0	-0.0	0.1	-0.8	0.2	-0.4	-1.3	-1.3	-0.6	-0.5	-2.3
Family relationship satisfaction	0.9	1.1	3.0	0.7	1.1	1.1	-0.1	-1.2	-1.7	0.4	0.3	0.5	1.0	1.5	1.7	-0.3
Leg pain on walking	0.6	0.8	2.2	0.2	-1.5	-1.4	-0.6	0.1	-0.5	-1.0	-0.5	-0.2	-1.2	-1.0	-1.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	4.1	-2.0	0.2	0.8	1.4	-0.7	-0.2	-1.6	-0.9	0.7	1.1	1.8	0.3	1.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	4.5	-0.1	0.2	1.2	2.1	-0.4	-1.3	0.7	-0.1	0.6	0.4	1.3	0.5	0.6
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	6.1	-1.7	1.3	-0.0	-0.0	-2.0	-0.5	-1.7	-2.2	1.7	1.8	2.5	1.8	1.4
Medication: Aspirin	1.4	1.8	6.0	0.0	1.1	1.6	2.5	0.4	-0.2	0.4	0.4	2.5	0.8	0.9	1.3	2.1
Supplements: Vitamin C	2.4	2.9	8.3	-2.9	1.3	0.9	0.3	-2.6	1.1	-1.5	-2.1	0.3	2.1	1.6	1.5	1.5
Knee pain experienced in last month	3.1	4.8	11.1	-1.7	-3.1	-3.0	-2.2	-1.3	-0.7	-3.2	-2.0	-0.5	-2.6	-0.3	-3.3	-1.5
Hypertension (Self-reported)	0.2	0.6	1.7	-0.0	-1.3	-1.0	-0.1	0.4	-0.4	-0.6	-0.6	-0.6	-1.0	0.8	-1.0	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.0	0.3	-0.0	-1.1	-0.0	1.2	0.6	-0.4	-0.2	0.9	0.6	1.4	-0.4	0.3
Illnesses of father: Heart disease	0.6	0.8	2.2	-0.9	0.4	-0.0	1.5	0.2	1.3	-0.9	-0.5	0.3	1.1	1.3	0.9	0.4
Illnesses of siblings: Diabetes	1.7	2.1	6.6	-0.2	1.6	2.6	1.9	-0.4	1.4	0.3	0.5	2.0	0.9	0.6	2.3	1.2
Smoking status: Previous	0.7	1.0	3.5	0.6	-1.6	-0.8	-1.2	-0.3	0.0	-0.7	-0.9	-0.2	-1.5	0.3	-0.7	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.6	-0.4	0.8	-0.5	-0.1	0.2	-1.0	0.3	0.2	-0.7	1.6	0.8	0.3	-0.0
Whole body fat-free mass	0.2	1.1	6.0	-0.9	0.9	-0.7	0.3	0.7	-2.5	0.1	0.9	0.1	2.0	0.4	-0.3	1.0
Leg fat-free mass (right)	0.3	1.6	5.8	-2.0	0.7	-1.5	-0.4	-0.3	-2.4	-1.1	-0.6	-0.1	2.3	1.0	-0.5	0.6
Arm fat percentage (left)	0.5	2.1	10.1	-3.2	0.1	-1.4	-0.2	-1.0	-0.0	-2.2	-1.7	0.2	1.4	1.3	-1.1	1.4
Average weekly red wine intake	0.2	0.2	1.2	0.3	-0.5	0.4	-0.5	0.7	-0.1	-0.1	-0.0	1.1	-0.5	0.6	-0.1	0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.1	1.3	-0.1	0.8	1.4	0.5	-0.3	0.1	0.0	0.9	-0.8	-0.8	0.5	0.3
Mood swings	0.4	0.7	1.7	0.6	-1.3	-0.8	-0.8	-0.5	-1.0	-0.9	-0.8	0.4	-1.1	0.5	-0.5	-1.0
Loneliness, isolation	0.3	0.4	1.1	0.7	0.3	-0.4	-0.2	0.6	-0.9	1.0	0.9	-0.8	0.8	0.5	0.0	-0.3
Long-standing illness, disability or infirmity	0.4	0.6	2.0	-0.0	-1.3	-0.8	0.7	0.1	-0.5	-1.4	-0.4	0.8	-1.2	-0.3	-0.9	-0.3
Ever had bowel cancer screening	0.9	1.0	3.0	0.8	-1.2	-1.1	-0.5	0.8	0.7	-0.3	0.5	-0.7	-1.7	-1.1	-1.4	-1.3
Diabetes diagnosed by doctor	0.5	0.9	2.8	1.0	0.2	0.7	0.2	1.1	-1.0	-0.2	0.7	1.7	-0.1	-1.6	0.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.6	-0.3	0.8	0.9	0.4	-0.3	-0.4	0.5	0.1	0.1	1.0	1.6	0.9	0.3
Friendships satisfaction	0.9	1.1	3.8	1.8	1.1	0.8	0.5	1.0	-0.3	0.9	1.9	0.7	0.9	-0.9	0.8	0.9
Qualifications: nursing, teaching	0.4	0.6	1.5	-1.1	-0.3	-0.4	-0.1	-1.1	-1.2	-0.9	-0.9	-0.4	-0.6	-0.9	-0.3	0.4
Commuting to job workplace: Walk	0.5	0.5	2.4	0.2	0.8	0.0	0.1	-0.4	-0.9	-0.2	0.7	0.9	0.6	-0.8	0.3	1.6
Eye problems/disorders: Cataract	3.1	3.6	7.9	-2.2	-1.9	-2.8	-1.9	-1.6	0.3	-2.5	-2.1	-1.7	-1.0	1.7	-2.1	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.8	-0.9	0.9	-0.4	0.3	-1.2	0.5	0.2	-0.0	-0.9	1.3	1.3	0.8	-0.5
Medication for cholesterol	0.3	0.4	1.0	1.0	0.4	0.2	-0.6	-0.0	0.9	0.8	0.9	-1.0	0.1	-0.8	0.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.7	0.1	-0.8	-0.7	1.3	0.7	-1.0	-0.3	-0.1	0.1	-0.3	-0.9	-0.6	-0.0
Back pain experienced in last month	0.2	0.3	1.0	-0.0	-0.6	-0.8	0.3	1.0	0.8	0.0	0.3	0.6	-0.3	0.2	-0.9	0.5
Mineral and other dietary supplements	1.0	1.3	2.7	-1.3	-1.5	-1.5	-1.6	-0.0	-0.6	-0.9	-1.0	-1.0	-0.8	1.2	-1.5	-0.6
Breast cancer (self-reported)	1.6	1.9	5.5	-0.4	-2.0	-2.3	-0.0	-0.5	-0.0	-0.6	-0.4	-1.8	-1.7	-0.1	-1.9	-2.2
Asthma (self-reported)	0.2	0.5	1.8	0.0	0.2	0.7	1.2	0.8	0.4	0.1	1.3	0.7	0.0	-0.5	0.2	1.0
Osteoporosis (self-reported)	1.2	1.5	3.4	-1.6	0.6	-0.4	0.2	-1.5	-1.3	-1.4	-1.7	1.4	1.0	-0.2	0.8	1.9
Osteoarthritis (self-reported)	0.3	0.4	2.6	0.1	-0.1	0.1	-0.5	0.2	1.3	-0.3	-0.4	1.6	-0.4	0.3	-0.1	0.3
Medication: Aspirin	1.1	1.4	4.4	0.0	0.9	1.5	2.1	0.3	-0.1	0.6	0.3	2.1	0.7	0.9	1.0	1.9
Medication: Gliclazide	0.4	0.4	2.2	-0.8	-0.2	0.1	-1.1	-0.7	-0.2	-1.5	-0.9	-0.1	0.2	-0.3	-0.1	0.3
Illnesses of father: None of the above (group 1)	1.0	1.2	7.2	0.5	-0.5	-0.6	-0.5	-0.4	-2.7	0.8	0.2	-1.5	-0.3	-1.2	-0.8	-1.6
Smoking status: Current	0.8	1.2	6.9	-1.3	-0.7	0.0	-0.7	-0.3	-1.0	-1.2	-1.8	-0.5	0.0	2.6	0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.0	0.2	-0.3	-0.0	1.3	-0.9	0.1	-0.6	-0.1	-0.7	-0.5	1.2	0.6	-1.4
Whole body water mass	0.2	1.1	5.9	-0.9	0.8	-0.8	0.3	0.8	-2.4	0.1	0.9	0.0	2.0	0.3	-0.4	0.9
Leg predicted mass (right)	0.3	1.6	5.3	-1.9	0.7	-1.5	-0.3	-0.3	-2.3	-1.1	-0.6	-0.1	2.3	1.0	-0.5	0.6
Arm fat mass (left)	0.5	1.9	9.3	-3.1	0.5	-1.3	0.3	-0.6	-0.9	-1.7	-0.9	0.3	1.8	1.1	-0.9	1.7
Number of self-reported non-cancer illnesses	0.6	1.0	4.6	-0.2	-1.2	-0.4	0.7	-0.3	0.7	-1.0	-1.2	1.6	-1.0	2.2	-0.0	-0.0
Average weekly champagne plus white wine intake	0.9	1.2	2.7	0.4	-1.6	-0.7	0.3	1.6	-0.6	-0.2	-0.2	-1.2	-1.5	-1.4	-1.6	-1.2
Miserableness	0.6	1.1	3.9	0.2	-1.8	-0.6	-0.3	-0.5	0.4	-1.0	-0.8	-0.1	-1.5	1.3	-0.4	-2.0
Guilty feelings	0.3	0.5	2.4	0.7	-0.6	0.1	1.2	-0.7	0.8	0.0	0.3	-0.1	-0.7	0.5	0.3	-1.5
Wears glasses or contact lenses	0.6	0.7	2.9	0.6	0.8	1.2	0.4	-0.9	0.7	-0.3	-0.2	1.3	0.0	0.8	1.7	-0.2
Ever taken oral contraceptive pill	2.3	2.5	7.6	2.1	0.1	0.7	0.3	2.2	2.0	2.8	2.3	-1.7	-0.3	-0.3	-0.1	-1.7
Hearing aid user	1.4	1.5	5.4	0.7	-1.9	-1.1	-0.8	0.7	0.4	-0.6	-0.4	-0.6	-2.3	-1.5	-1.4	-1.6
Mother’s age at death	0.9	1.1	5.7	0.5	1.1	2.4	1.0	0.3	0.2	1.0	0.9	0.9	0.9	-0.0	1.6	0.9
Financial situation satisfaction	0.6	0.7	1.8	0.9	-1.2	-0.5	0.3	-0.6	-0.7	-1.2	-0.5	0.4	-1.3	0.6	-0.4	-1.1
Tinnitus: Yes, now most or all of the time	2.4	2.8	12.8	-1.9	0.4	0.5	0.8	-2.0	-3.6	-1.5	-2.1	0.5	1.2	2.4	1.1	0.5
Commuting to job workplace: Public transport	2.9	3.5	9.1	0.2	-1.8	-2.8	-3.0	0.7	1.1	-0.7	-0.7	-2.1	-2.0	-2.1	-2.0	-2.2
Eye problems/disorders: Glaucoma	0.4	0.5	2.1	-0.5	-0.2	-0.4	-0.4	-1.5	0.8	-0.9	-0.9	-0.0	-0.3	0.9	0.1	-0.9
Medication: Blood pressure	0.8	1.5	4.0	-1.9	-1.0	-1.4	0.1	-1.0	-1.5	-2.0	-1.8	0.3	-0.3	0.8	-1.3	-0.1
Pain type(s) experienced in last month: Hip pain	1.5	1.9	7.1	1.2	-1.8	-0.8	-2.0	0.6	0.1	-0.4	-0.1	0.9	-2.7	-1.3	-2.0	-1.0
Supplements: Fish oil (including cod liver oil)	1.1	1.5	6.3	1.5	1.4	2.5	1.2	-0.3	-0.0	1.0	0.9	1.5	0.4	-0.4	1.7	0.3
High cholesterol (Self-reported)	0.3	0.5	3.1	0.6	0.6	-0.2	-0.1	-0.6	-1.8	-0.1	-0.5	0.8	0.1	0.6	0.8	-0.1
Medication: Bendroflumethiazide	0.9	1.4	4.3	-2.1	-0.4	-1.0	-1.2	-1.4	0.6	-1.8	-2.0	-0.2	0.2	1.0	-0.9	0.1
Medication: Paracetamol	0.3	0.5	1.6	0.4	-1.3	-1.2	0.1	0.0	-0.2	-0.6	-0.6	0.3	-1.3	-0.2	-0.7	-0.5
Medication: Lisinopril	1.5	2.0	5.2	-1.9	0.4	0.4	-0.1	-1.9	0.1	-1.9	-2.3	1.9	0.7	1.9	1.1	0.7
Medication: Atorvastatin	0.2	0.2	0.6	-0.7	0.1	-0.7	0.4	-0.2	0.1	-0.6	-0.8	0.3	0.5	-0.1	0.0	0.7
Illnesses of father: High blood pressure	0.1	0.2	1.2	-0.1	0.2	0.0	-0.4	0.2	1.1	-0.1	-0.1	0.2	0.2	0.7	0.2	0.3
Alcohol drinker status: Never	0.2	0.3	1.3	-0.4	-0.1	-0.4	0.5	-0.1	-0.7	-0.5	-0.6	1.2	-0.5	0.0	-0.0	0.6
Ever smoked	0.6	1.1	6.8	-0.8	0.3	1.0	-0.7	-0.9	-0.7	-0.5	-1.0	0.7	0.4	2.6	1.5	-0.0
Basal metabolic rate	0.2	1.2	5.9	-1.4	0.7	-1.0	0.2	0.4	-2.4	-0.3	0.5	0.1	2.1	0.7	-0.5	1.0
Leg fat percentage (left)	0.6	2.2	8.3	-2.7	1.3	0.5	0.9	-0.5	-0.2	-0.9	-0.5	1.6	1.9	1.6	0.2	2.9
Arm fat-free mass (left)	0.2	1.2	5.7	-0.9	1.0	-0.3	0.8	0.7	-2.4	0.4	1.2	0.2	2.0	0.3	-0.1	1.2
Number of operations (self-reported)	0.6	0.9	4.7	0.9	0.4	1.2	0.2	-0.0	1.0	0.5	0.5	2.2	-0.8	1.3	0.7	1.0
Average weekly beer plus cider intake	0.6	0.9	3.8	1.6	0.7	1.3	-0.5	0.4	-0.4	1.9	1.4	-0.3	0.3	0.2	0.8	0.1
Irritability	0.3	0.5	1.4	0.5	-1.1	-0.9	-0.3	-0.9	0.0	-0.8	-0.7	-0.1	-1.2	-0.0	-0.5	-0.9
Risk taking	0.4	0.6	2.5	0.1	0.3	1.6	0.8	0.2	-0.6	-0.1	0.6	1.0	0.2	-0.2	0.7	1.5
Ever had prostate specific antigen (PSA) test	1.6	1.9	4.4	-2.1	-0.8	-1.9	-1.2	-1.7	-0.2	-1.6	-1.3	-1.3	-0.2	-1.5	-1.6	0.0
Fractured/broken bones in last 5 years	1.9	2.4	6.4	-2.4	0.1	-2.2	-0.7	-2.5	0.3	-2.5	-2.3	-0.0	0.7	-0.1	-0.6	1.2
Age started oral contraceptive pill	0.6	0.8	4.4	1.2	-0.6	0.3	-0.2	0.1	-0.7	0.3	0.3	0.2	-1.6	-2.1	-0.7	-0.7
Diastolic blood pressure, automated reading	1.0	3.2	8.3	-2.9	0.6	0.3	-1.3	-2.6	0.2	-1.7	-2.8	0.1	1.9	2.6	1.4	0.8
Ever depressed for a whole week	1.3	1.6	5.7	-1.8	0.4	-0.2	-0.5	-1.8	-1.4	-2.4	-1.8	0.1	1.0	0.9	0.9	0.8
Unable to work because of sickness or disability	0.3	0.4	1.5	1.2	-0.4	0.3	0.8	0.5	0.6	0.3	0.5	1.2	-1.0	-0.1	-0.1	0.1
Commuting to job workplace: Cycle	0.9	1.1	3.8	1.5	0.5	1.5	-0.2	-0.2	1.4	0.0	0.5	1.9	-0.5	-0.8	1.5	0.7
Myopia	0.2	0.4	1.6	-0.4	-0.9	-1.2	-0.1	0.8	0.6	-0.4	-0.6	-0.0	-0.5	0.2	-0.6	-0.3
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	-0.6	1.0	0.7	0.6	-0.9	0.8	0.3	0.6	-0.2	1.0	-0.6	0.5	0.9
Cholesterol lowering medication	0.3	0.5	1.3	0.1	1.1	0.4	0.3	-0.4	-1.1	0.6	0.0	0.6	0.9	0.6	1.0	0.5
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.1	1.4	-0.8	-0.3	1.3	1.4	0.7	0.4	0.5	1.5	-1.4	0.1	-0.4	-0.2
Pain experienced in last month	1.1	1.8	6.1	-1.2	1.8	1.2	1.6	-0.2	-1.8	0.8	0.5	-1.1	2.5	0.3	0.9	1.3
Supplements: Calcium	1.5	1.7	4.2	1.9	2.1	1.5	0.6	0.3	-0.3	1.3	1.6	1.0	0.7	-1.0	1.8	0.9
Basal cell carcinoma (self-reported)	0.7	0.8	3.6	-0.8	-1.2	0.3	-1.2	-0.4	0.7	-0.2	-0.8	-1.9	-0.3	-0.1	-0.8	-1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.5	0.7	0.8	0.5	0.0	0.4	-1.2	1.0	0.9	0.8	0.3	0.4	0.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.4	-0.8	0.4	-0.3	-0.5	-0.5	1.2	0.3	0.1	-1.6	1.2	0.1	-0.3	-0.3
Heart disease (siblings)	0.3	0.4	1.9	0.6	-0.3	-0.4	-0.7	0.7	0.3	0.7	0.2	-0.1	-0.5	1.4	-0.0	-1.1
Alcohol drinker status: Previous	0.7	0.8	3.3	0.3	0.6	1.3	0.8	-0.5	-1.8	1.2	0.2	-0.3	0.6	0.7	1.2	-0.8
Pack years of smoking	1.5	2.1	6.7	0.6	-2.4	-1.9	-1.1	0.1	0.6	-1.2	-1.3	-0.9	-1.6	1.4	-1.2	-2.6
Impedance of whole body	0.3	1.7	7.7	1.6	-1.4	-0.6	-1.2	0.3	0.0	0.5	-0.4	-1.2	-2.8	-0.8	-1.0	-2.0
Leg fat mass (left)	0.5	2.1	7.9	-2.8	1.1	-0.1	1.0	-0.4	-0.7	-1.3	-0.6	1.5	2.0	1.4	-0.0	2.5
Arm predicted mass (left)	0.2	1.2	6.2	-1.1	0.8	-0.4	0.7	0.7	-2.5	0.3	1.1	0.2	1.9	0.4	-0.3	1.2