Hub : Genes

PCP4L1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0240	8.8e-03	0.057	0.009	0.039	0.020	0.054	1.7e-07	2.4e-02	1.4e-05	1.4e-03	3.2e-07
2	GTEx	Brain Cerebellum	0.2730	0.0910	3.6e-03	0.024	NA	-0.003	NA	0.010	6.6e-02	NA	4.1e-01	NA	1.6e-01
3	NTR	Blood	0.0364	0.0108	1.1e-06	0.035	0.020	0.035	0.032	0.037	2.4e-11	2.4e-07	1.7e-11	1.3e-10	6.0e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.8	2.8	5.6	-1.5	2.4	0.8
Bipolar Disorder or Schizophrenia	2.0	4.8	8.7	-1.7	2.9	1.7
Depressed Affect (Nagel 2018)	0.5	1.0	2.0	-1.4	1.0	-0.2
Depression (Nagel 2018)	0.8	1.3	2.7	-0.9	0.6	1.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.2	-0.5	-0.5	1.1
Neuroticism (Nagel 2018)	0.3	0.8	1.3	-0.8	1.1	0.6
Schizophrenia (2018)	1.1	2.3	3.5	-1.0	1.9	1.5
Schizophrenia vs Biploar Disorder	1.7	2.3	3.5	1.9	-0.9	-1.6
Worry (Nagel 2018)	0.9	1.9	2.6	-1.6	1.5	0.9
Alzheimer’s Disease (in mother)	3.4	4.0	6.3	-1.2	2.5	2.1
Alzheimer’s Disease (in father)	1.6	1.8	5.1	-0.4	2.2	0.2
Alzheimer’s Disease (including proxy)	4.0	5.8	10.6	-1.7	3.2	2.0
Crohns Disease (2017)	2.2	4.9	9.9	-1.0	3.1	-1.9
Irritable Bowel Disease (IBD)	1.8	4.3	6.9	-1.9	2.6	-1.5
Ulcerative Colitis (UC)	0.8	1.5	3.4	-1.8	1.0	-0.4
Major Depression (MDD)	0.7	0.9	1.5	-0.1	-1.2	1.1
Reaction Time	1.1	2.1	3.8	-1.6	0.2	2.0
Verbal and Numeric Reasoning (VNR)	1.4	3.3	8.9	-0.9	0.3	3.0
Breast Cancer	0.2	0.4	0.5	-0.7	-0.7	0.4
Ovarian Cancer	1.9	2.6	3.7	1.4	1.5	-1.9
Prostate Cancer	0.3	0.4	0.9	0.9	0.6	-0.2
Age at First Birth	2.2	3.2	5.0	1.1	2.2	-1.9
Bipolar Disorder (2011)	3.1	3.0	8.0	-0.9	2.8	-0.2
Body Mass Index (BMI) (2010)	0.4	0.5	0.8	-0.2	-0.9	0.8
Coronary Artery Disease (CAD)	1.2	1.4	4.1	-0.1	0.1	2.0
Crohns Disease (2012)	2.6	4.2	5.9	-1.5	2.1	-2.4
Mean Putamen Volume	1.0	1.1	2.4	0.8	0.5	-1.6
Fasting Glucose	0.3	0.4	0.5	-0.7	0.2	-0.7
HbA1C	0.3	0.3	0.7	0.5	-0.0	-0.9
HDL Cholesterol	0.4	0.7	1.9	1.4	-0.4	-0.2
LDL Cholesterol	0.4	0.6	1.3	-1.2	0.5	0.5
Lupus	0.8	1.2	2.7	-1.6	0.9	-0.4
Neuroticism (2016)	0.4	0.6	1.4	-0.5	1.2	0.5
Primary Biliary Cirrhosis	0.8	1.1	1.5	0.7	-1.2	1.2
Rheumatoid Arthritis	0.3	0.4	0.9	1.0	-0.1	0.3
Schizophrenia (2014)	1.0	2.2	3.3	-0.9	1.6	1.8
Triglycerides	0.4	0.7	1.9	-1.4	0.4	-0.3
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.0	-0.7	1.1	1.4
Ulcerative Colitis	0.9	1.3	1.9	-1.4	0.7	-1.2
Blood Eosinophil Count	0.9	6.6	11.3	3.4	-2.6	-1.3
Blood Platelet Count	0.3	3.2	4.0	-1.6	2.0	-1.8
Blood Red Count	0.3	2.8	8.4	0.2	-2.9	-0.2
Blood White Count	1.1	8.3	10.0	3.2	-2.3	-3.1
Heel T-Score	0.1	0.7	2.0	-1.4	0.0	0.3
BMI	0.4	2.1	4.2	-1.0	-2.0	1.0
Height	0.1	1.0	2.1	-1.4	-0.1	-0.9
Waist Hip Ratio (WHR)	0.8	3.4	8.0	-2.8	0.4	1.5
Systolic Blood Pressure	0.4	1.8	4.6	0.9	-2.1	-0.0
Smoking Status	0.1	0.3	0.4	0.5	0.7	-0.5
Allergy or Eczema	3.4	8.8	26.5	5.2	-0.0	0.1
Cardiovascular Disease	0.3	0.9	1.5	-1.1	-0.2	1.2
Hypothyroidism (self reported)	0.3	0.7	1.0	0.7	-1.0	0.8
Respiratory disease	1.1	2.5	4.1	2.0	-1.6	1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.3	0.7	0.8
Lung FEV1/FVC ratio	0.6	2.9	8.4	-0.1	2.9	-0.5
Lung FVC	0.8	4.1	11.2	-0.7	-0.8	3.3
Neuroticism	1.1	2.7	5.9	-1.5	2.4	-0.1
Chronotype (morning person)	0.8	1.8	2.8	1.6	1.7	-0.1
Hair Pigment	0.0	0.1	0.2	-0.5	0.0	0.1
Tanning	0.1	1.5	2.6	-0.8	-1.6	-1.1
Hand grip strength (left)	0.7	1.7	4.5	0.6	-2.1	-0.6
Number of treatments/medications taken	0.1	0.1	0.3	-0.1	-0.5	0.3
Average weekly spirits intake	0.2	0.3	0.4	-0.0	-0.6	-0.6
Sensitivity / hurt feelings	0.5	0.9	2.2	-1.5	0.7	-0.1
Frequency of depressed mood in last 2 weeks	0.8	1.1	1.5	-1.2	1.0	0.9
Hearing difficulty/problems: Yes	0.6	0.9	2.6	0.0	-1.6	0.2
Relative age of first facial hair	0.7	1.5	3.3	0.8	1.8	0.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	-0.9	-0.6	0.6
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.9	-1.2	0.9	2.0
Ever had hysterectomy (womb removed)	2.3	2.6	4.9	-2.2	0.8	1.5
Systolic blood pressure, automated reading	0.4	1.2	3.1	-0.4	-1.8	0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.0	1.0	-0.0	-0.8
Angina	0.3	0.4	0.7	0.1	-0.8	-0.8
Medication for hormone replacement therapy	1.3	1.4	3.5	0.2	0.8	1.9
Vitamin and mineral supplements	1.4	1.9	2.6	-1.0	-1.5	1.6
Supplements: Zinc	0.6	0.7	1.1	-0.1	1.0	-1.0
Medication: Co-codamol	0.7	0.8	1.2	-1.0	-0.1	1.1
Medication: Metformin	0.4	0.6	0.8	-0.6	0.9	0.8
Diabetes (father)	0.4	0.5	0.8	-0.8	0.9	-0.1
Diabetes (mother)	1.0	1.3	3.3	-1.8	-0.4	0.7
Severe depression (siblings)	1.3	1.4	3.8	-0.6	0.4	1.9
Pack years adult smoking proportion	1.3	2.0	3.6	-1.0	1.2	-1.9
Impedance of leg (right)	0.0	0.2	0.6	0.0	0.3	-0.8
Leg fat-free mass (left)	0.2	1.2	2.6	-1.6	-0.9	0.6
Trunk fat percentage	0.3	1.1	2.2	-0.7	-0.8	1.5
Hand grip strength (right)	0.3	0.7	1.3	-0.0	-1.1	-0.9
Townsend deprivation index at recruitment	0.5	0.7	1.8	1.3	-0.6	0.3
Current tobacco smoking	0.5	0.9	1.9	-0.8	1.4	-0.1
Average weekly fortified wine intake	2.1	2.4	5.8	-0.5	2.4	-1.1
Maternal smoking around birth	1.5	2.2	6.4	0.5	-0.1	2.5
Fed-up feelings	1.6	2.8	3.9	-2.0	1.9	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	3.5	-1.7	0.3	1.9
Relative age voice broke	1.4	2.2	6.0	-0.3	2.4	-0.7
Taking other prescription medications	1.4	2.2	2.9	-1.3	-1.7	1.4
Age when periods started (menarche)	1.7	4.0	5.5	2.3	1.2	-2.3
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	7.3	-1.2	-0.7	2.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	-0.0	-0.8	0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	-1.1	-0.6	0.3
Qualifications: CSEs or equivalent	0.5	0.6	1.7	0.4	1.3	-0.3
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.6	0.2	0.9
High blood pressure	0.4	1.1	2.2	-1.5	-0.8	0.8
Hayfever, allergic rhinitis or eczema	2.9	6.3	18.6	4.3	-0.4	0.3
Multivitamins +/- minerals	2.2	2.7	3.9	2.0	2.0	-0.7
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.4	-0.4	0.3
Supplements: Glucosamine	0.4	0.6	1.5	0.3	1.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.5	0.3	0.7	0.5
Medication: Atenolol	1.1	1.3	1.6	-1.0	-1.2	-1.2
Medication: Levothyroxine sodium	0.2	0.4	0.9	0.5	-0.9	-0.2
Sitting height	0.2	1.3	3.7	-1.9	-0.1	-0.3
Chronic bronchitis/emphysema (father)	1.5	1.8	3.2	0.6	-1.4	1.8
High blood pressure (mother)	0.7	0.9	1.6	0.2	-1.3	1.1
Body mass index (BMI)	0.4	1.9	2.7	-0.9	-1.4	1.6
Impedance of leg (left)	0.1	0.5	1.0	-0.2	1.0	-0.7
Leg predicted mass (left)	0.2	1.2	2.4	-1.5	-1.0	0.6
Trunk fat mass	0.3	1.3	1.4	-1.2	-1.1	1.2
Waist circumference	0.9	3.3	5.7	-2.4	-1.6	1.3
Number of incorrect matches in round	0.2	0.4	1.0	-0.4	0.0	1.0
Past tobacco smoking	0.4	0.7	1.1	-0.8	0.5	1.0
Alcohol usually taken with meals	0.0	0.1	0.1	-0.3	-0.2	0.3
Nervous feelings	1.6	3.0	6.9	-1.3	2.6	0.6
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.8	9.5	-1.2	3.1	0.7
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.1	-0.2	0.3
Hair/balding pattern: Pattern 2	0.6	0.7	1.1	0.9	-1.1	-0.5
Had menopause	0.4	0.5	0.6	-0.8	-0.5	0.7
Had other major operations	1.3	1.5	4.1	-2.0	0.7	0.1
Forced vital capacity (FVC)	0.3	1.2	3.2	-0.5	-0.4	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.3	-0.1	0.3	1.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.2	-0.5	1.8	-0.1
Qualifications: None of the above	0.9	2.0	5.3	-0.6	-2.3	0.4
Financial difficulties in last 2 years	3.5	4.7	8.9	-3.0	1.3	1.9
Mouth/teeth dental problems	0.6	0.9	1.3	-1.2	-1.1	-0.4
Heart attack	0.7	0.9	1.6	1.3	-1.0	-0.1
Allergy	1.5	3.3	7.7	-2.8	0.6	-1.4
Pain all over the body in last month	1.9	2.0	3.2	-1.8	1.5	0.7
Diabetes (self-reported)	0.0	0.0	0.0	-0.0	0.2	-0.0
Hayfever/allergic rhinitis (self-reported)	3.7	4.9	12.3	3.5	-1.1	-1.2
Medication: Ramipril	0.6	0.7	1.3	-0.8	-0.4	1.1
Medication: Simvastatin	0.3	0.4	1.2	-0.2	1.1	-0.0
Fluid intelligence score	0.2	0.4	0.7	0.1	-0.7	0.9
Illnesses of siblings	3.5	5.0	11.1	1.9	0.4	-3.3
Neuroticism score	0.8	1.7	4.1	-1.0	2.0	-0.2
Weight	0.4	1.8	2.5	-1.6	-1.4	1.0
Impedance of arm (right)	0.4	1.8	5.2	0.3	2.3	0.1
Arm fat percentage (right)	0.2	0.8	2.0	-0.4	-0.4	1.4
Trunk fat-free mass	0.3	1.7	3.2	-1.8	-1.4	-0.1
Hip circumference	0.2	0.7	2.0	-0.2	-1.4	0.2
Time employed in main current job	0.3	0.4	0.5	-0.7	0.3	-0.7
Alcohol intake versus 10 years previously	0.9	1.3	3.1	-0.9	0.1	1.8
Father’s age at death	0.2	0.3	0.5	0.7	0.3	0.4
Worrier / anxious feelings	0.9	1.6	2.2	-1.3	1.0	1.5
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	6.2	-1.6	0.9	2.5
Falls in the last year	0.1	0.1	0.2	0.2	-0.5	0.3
Hair/balding pattern: Pattern 3	0.5	0.8	2.1	0.3	0.5	1.5
Number of live births	0.9	1.3	2.0	-1.3	-1.4	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.7	-0.6	0.2	1.3
Pulse rate	1.4	2.4	5.4	-1.2	2.3	-0.7
Happiness	0.4	0.5	1.3	0.4	1.1	0.3
Noisy workplace	0.1	0.1	0.3	-0.2	-0.2	-0.5
Qualifications: A levels/AS levels or equivalent	1.0	2.3	4.1	2.0	1.6	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.8	-1.7	1.2	0.8
Mouth/teeth dental problems: Dentures	1.1	1.8	4.6	2.2	-0.3	-0.9
Asthma	1.7	3.4	4.6	1.1	-2.1	2.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.5	1.2	-1.1	0.2
Medication: Cholesterol lowering	0.3	0.5	1.2	-0.6	-0.0	1.1
Depression (self-reported)	1.1	1.3	3.4	-0.6	1.9	-0.4
Medication: Lansoprazole	0.6	0.7	1.4	-1.2	0.4	0.6
Prospective memory result	1.2	1.5	3.1	-1.8	1.1	0.5
Lung cancer (father)	0.5	0.5	0.8	0.1	-0.9	0.9
Illnesses of mother	1.3	1.6	2.2	1.5	0.6	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.4	-0.7	-0.0	1.2
Pulse wave Arterial Stiffness index	0.7	0.8	1.8	-0.7	0.2	-1.3
Impedance of arm (left)	0.3	1.3	3.7	0.5	1.9	-0.2
Arm fat mass (right)	0.4	1.5	2.1	-1.0	-1.2	1.5
Trunk predicted mass	0.3	1.7	3.3	-1.8	-1.4	-0.1
Standing height	0.1	1.4	3.1	-1.8	-0.2	-1.0
Length of working week for main job	0.3	0.3	0.6	-0.3	0.5	0.8
Exposure to tobacco smoke at home	0.6	0.6	1.3	-0.6	-0.5	1.1
Breastfed as a baby	0.6	0.8	1.4	-1.2	0.7	0.7
Tense / ‘highly strung’	1.6	2.6	4.1	-2.0	1.9	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.7	-0.1	1.3	0.0
Hair/balding pattern: Pattern 4	0.4	1.0	1.9	0.9	-0.5	-1.4
Birth weight of first child	0.7	1.2	1.4	-1.0	1.1	-1.2
Peak expiratory flow (PEF)	0.3	0.7	1.4	0.2	-0.9	1.2
Pulse wave reflection index	0.7	0.8	1.2	-0.9	-0.8	1.1
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.1	-1.5	0.9	0.0
Loud music exposure frequency	0.1	0.1	0.2	0.2	0.1	0.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.6	-0.8	1.6	0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	0.3	-0.3	1.1
Blood clot in the leg (DVT)	1.9	2.5	2.9	-1.5	-1.5	1.7
Medication: Paracetamol	0.2	0.3	0.8	-0.9	0.1	-0.1
Headache pain in last month	0.4	0.7	1.2	0.9	-0.2	1.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	-0.1	0.4	0.4
Glaucoma (self-reported)	0.1	0.1	0.1	-0.3	-0.2	0.4
Gout (self-reported)	0.5	0.7	0.9	0.9	0.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.1	0.3	-1.1	0.9
Medication: Amlodipine	0.3	0.4	0.8	-0.6	-0.3	0.9
Medication: Ventolin 100micrograms inhaler	1.6	2.0	4.0	2.0	-1.4	0.1
Birth weight	1.1	2.4	3.7	0.8	-1.9	-1.7
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	0.7	0.2	0.7
High blood pressure (siblings)	2.5	3.6	6.3	-2.1	-0.2	2.5
Forced vital capacity (FVC), Best measure	0.4	1.5	3.4	-0.8	-0.6	1.8
Body fat percentage	0.2	0.8	1.4	-0.8	-0.6	1.2
Leg fat percentage (right)	0.3	1.2	1.7	-1.0	-0.9	1.3
Arm fat-free mass (right)	0.5	2.4	3.8	-1.9	-1.8	0.5
Exposure to tobacco smoke outside home	0.2	0.2	0.6	-0.3	-0.8	-0.3
Comparative body size at age 10	0.3	0.7	1.5	-0.6	-1.2	0.4
Number of full brothers	0.4	0.5	0.6	-0.7	0.6	0.8
Worry too long after embarrassment	0.5	0.8	1.9	-0.3	1.4	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	5.5	-2.4	1.0	1.1
Wheeze or whistling in the chest in last year	0.6	1.0	2.3	0.8	-1.5	0.1
Number of children fathered	1.1	1.2	2.3	0.7	-1.5	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.0	1.0	-0.4	-0.3
Age at first live birth	1.1	1.9	3.2	1.1	1.8	-1.1
Pulse wave peak to peak time	0.6	0.7	1.6	0.6	-0.3	1.3
Health satisfaction	1.5	1.9	3.5	-1.1	1.9	1.0
Shortness of breath walking on level ground	1.0	1.2	2.2	-0.8	1.5	-0.9
Qualifications: College or University degree	0.9	3.0	4.8	2.2	1.0	-1.8
Eye problems/disorders: None of the above	0.5	0.6	0.6	-0.8	-0.8	-0.7
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	1.2	-0.7	0.0
Emphysema/chronic bronchitis	0.5	0.5	1.1	-0.7	0.2	1.0
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	-0.1	0.5	0.2
Neck or shoulder pain in last month	0.4	0.5	1.2	-0.3	-0.4	1.1
Medication: Blood pressure	0.8	1.3	3.3	0.3	-1.8	-0.8
Angina (self-reported)	0.3	0.4	0.6	-0.1	-0.8	-0.7
Migraine (self-reported)	0.7	0.9	2.2	-0.6	-1.5	-0.3
Medication: Ibuprofen	0.5	0.6	0.8	0.6	-0.9	0.7
Medication: Allopurinol	0.2	0.2	0.6	0.0	-0.3	-0.8
Medication: Omeprazole	0.4	0.5	1.4	-1.2	-0.4	0.1
Medication: Seretide 50 evohaler	1.3	1.5	2.0	1.1	-1.4	1.1
Mean time to correctly identify matches	1.0	1.8	3.4	-1.8	-0.4	1.4
Heart disease (mother)	0.9	1.0	2.4	-1.6	-0.7	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.4	0.2	-0.5	-1.2
Whole body fat mass	0.3	1.2	2.0	-1.4	-0.7	1.1
Leg fat mass (right)	0.4	1.5	2.5	-1.6	-1.0	1.0
Arm predicted mass (right)	0.4	2.2	4.1	-2.0	-1.4	0.7
Pulse rate, automated reading	0.2	0.6	1.7	-1.3	0.2	0.2
Alcohol intake frequency.	0.8	1.8	5.0	-0.7	-0.2	2.2
Comparative height size at age 10	0.5	2.8	4.9	-2.2	-1.6	-1.0
Number of full sisters	0.5	0.7	1.6	-0.5	-0.3	-1.3
Suffer from ‘nerves’	1.8	2.8	3.3	-1.4	1.8	1.8
Overall health rating	0.9	1.9	2.3	-1.4	-1.5	1.2
Chest pain or discomfort	0.2	0.4	0.9	-1.0	0.1	-0.3
Had major operations	1.0	1.1	2.3	1.0	-0.3	-1.5
Age at last live birth	1.1	1.6	3.7	-0.1	1.0	-1.9
Family relationship satisfaction	1.4	1.7	4.5	-0.6	0.5	2.1
Leg pain on walking	1.7	2.2	4.8	-2.2	1.2	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.6	-0.3	0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.4	-1.2	0.2	-0.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.2	1.0	-0.1	-1.8
Medication: Aspirin	1.0	1.3	1.8	1.2	-1.4	-0.8
Supplements: Vitamin C	0.2	0.2	0.4	-0.6	-0.4	-0.5
Knee pain experienced in last month	1.0	1.6	3.6	-1.9	-1.0	0.3
Hypertension (Self-reported)	0.7	2.0	3.3	-1.8	-0.9	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.2	2.9	-1.7	-1.6	-0.9
Illnesses of father: Heart disease	0.2	0.3	0.9	-1.0	0.1	-0.1
Illnesses of siblings: Diabetes	1.8	2.3	3.9	-2.0	-0.4	1.7
Smoking status: Previous	0.9	1.3	2.1	1.2	-0.7	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.8	-1.7	-0.8	-0.9
Whole body fat-free mass	0.2	1.4	2.6	-1.6	-1.3	0.2
Leg fat-free mass (right)	0.2	1.0	2.4	-1.6	-0.6	0.6
Arm fat percentage (left)	0.2	0.7	1.7	-0.5	-0.5	1.3
Average weekly red wine intake	0.6	0.9	2.5	1.6	-0.0	-0.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.1	0.8	0.2	-1.0
Mood swings	1.0	1.7	2.6	-1.5	1.6	-0.5
Loneliness, isolation	0.7	1.0	3.1	-1.8	0.1	0.1
Long-standing illness, disability or infirmity	0.6	0.9	1.1	-1.0	-0.8	1.0
Ever had bowel cancer screening	0.3	0.3	1.0	-1.0	-0.2	-0.1
Diabetes diagnosed by doctor	0.2	0.3	0.4	-0.2	0.6	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.7	-0.3	-0.5
Friendships satisfaction	1.1	1.3	2.4	-1.2	0.1	1.6
Qualifications: nursing, teaching	0.9	1.4	3.7	-0.6	1.9	0.4
Commuting to job workplace: Walk	1.4	1.5	2.1	1.5	1.2	-0.9
Eye problems/disorders: Cataract	0.8	0.9	2.4	0.3	1.6	0.3
Mouth/teeth dental problems: Mouth ulcers	3.8	6.1	12.5	2.3	3.5	0.6
Medication for cholesterol	0.9	1.4	2.9	1.1	-0.0	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.3	1.8	0.3	-0.3
Back pain experienced in last month	2.5	3.6	8.2	-1.2	-1.1	2.9
Mineral and other dietary supplements	2.6	3.5	6.1	-1.0	-1.8	2.5
Breast cancer (self-reported)	0.1	0.1	0.1	0.2	-0.2	0.4
Asthma (self-reported)	1.6	3.2	4.6	0.9	-2.2	2.1
Osteoporosis (self-reported)	0.4	0.5	0.8	0.5	0.9	-0.7
Osteoarthritis (self-reported)	1.0	1.3	1.7	0.9	1.2	-1.3
Medication: Aspirin	1.2	1.5	1.6	1.3	-1.3	-1.1
Medication: Gliclazide	0.3	0.4	1.0	-1.0	-0.2	-0.3
Illnesses of father: None of the above (group 1)	0.3	0.3	0.9	0.9	0.1	0.3
Smoking status: Current	0.5	0.8	2.2	-0.3	1.5	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.6	0.5	-1.2	2.1
Whole body water mass	0.3	1.4	2.4	-1.6	-1.4	0.2
Leg predicted mass (right)	0.2	1.1	2.6	-1.6	-0.7	0.6
Arm fat mass (left)	0.3	1.2	1.7	-1.0	-0.9	1.3
Number of self-reported non-cancer illnesses	1.3	2.3	4.5	-0.6	-2.1	1.4
Average weekly champagne plus white wine intake	0.6	0.8	1.2	0.8	0.7	-1.1
Miserableness	1.1	1.9	4.8	-0.9	2.2	-0.2
Guilty feelings	1.3	1.9	3.5	1.4	1.9	0.1
Wears glasses or contact lenses	0.6	0.7	1.9	-0.4	1.4	0.3
Ever taken oral contraceptive pill	1.3	1.4	3.6	0.7	1.9	0.2
Hearing aid user	1.0	1.2	1.7	-0.6	1.3	1.1
Mother’s age at death	2.4	3.0	4.8	0.9	2.2	-1.9
Financial situation satisfaction	0.8	1.0	3.0	-1.7	-0.3	-0.2
Tinnitus: Yes, now most or all of the time	2.4	2.8	4.3	1.8	-2.1	-0.9
Commuting to job workplace: Public transport	0.9	1.0	1.4	0.9	1.0	-1.2
Eye problems/disorders: Glaucoma	0.4	0.4	0.5	0.7	0.7	0.6
Medication: Blood pressure	1.2	2.4	4.1	-1.7	0.4	2.0
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	0.2	0.3	0.2
Supplements: Fish oil (including cod liver oil)	2.2	2.8	5.0	1.4	1.2	-2.2
High cholesterol (Self-reported)	0.2	0.4	0.7	-0.8	0.5	0.5
Medication: Bendroflumethiazide	0.3	0.5	1.2	-1.1	-0.1	0.5
Medication: Paracetamol	0.0	0.1	0.1	-0.3	0.1	-0.4
Medication: Lisinopril	0.1	0.1	0.2	-0.5	0.4	0.3
Medication: Atorvastatin	0.5	0.6	1.8	-0.0	-1.3	0.2
Illnesses of father: High blood pressure	0.7	0.9	2.3	-1.5	0.3	0.4
Alcohol drinker status: Never	0.8	1.0	1.3	-0.8	-1.0	1.2
Ever smoked	0.3	0.6	1.7	-0.1	0.0	-1.3
Basal metabolic rate	0.3	1.5	2.6	-1.6	-1.3	0.4
Leg fat percentage (left)	0.3	1.0	1.3	-1.1	-0.6	1.1
Arm fat-free mass (left)	0.4	1.9	2.9	-1.7	-1.5	0.7
Number of operations (self-reported)	0.2	0.3	0.4	-0.6	-0.4	-0.6
Average weekly beer plus cider intake	0.5	0.7	1.8	0.2	0.6	1.3
Irritability	0.5	0.8	2.1	-0.2	-0.5	-1.4
Risk taking	0.7	1.0	2.9	-1.7	0.4	0.0
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.1	1.2	-1.4	-0.2
Fractured/broken bones in last 5 years	0.2	0.3	0.6	0.4	-0.8	-0.4
Age started oral contraceptive pill	0.4	0.6	1.6	-1.3	0.2	0.3
Diastolic blood pressure, automated reading	0.5	1.7	2.6	-1.6	-1.6	0.3
Ever depressed for a whole week	0.5	0.7	1.0	-0.9	1.0	0.4
Unable to work because of sickness or disability	2.9	3.7	7.2	-2.7	0.5	1.9
Commuting to job workplace: Cycle	0.4	0.5	1.2	1.1	0.1	-0.4
Myopia	0.6	0.9	2.1	-0.4	-1.5	-0.7
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.0	1.0	0.7	-0.8
Cholesterol lowering medication	0.3	0.4	1.0	-0.4	-0.1	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	-1.1	-0.2	0.1
Pain experienced in last month	1.8	3.0	6.3	2.5	0.3	-1.6
Supplements: Calcium	1.1	1.2	1.9	1.3	-1.4	-0.4
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	-0.4	-0.9	0.5
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.2	0.9	-1.1	0.4
Deep venous thrombosis (DVT) (self-reported)	1.7	2.1	2.5	-1.6	-1.3	1.5
Heart disease (siblings)	0.6	0.8	1.5	-1.2	0.1	0.9
Alcohol drinker status: Previous	2.2	2.5	5.0	-0.1	1.6	2.2
Pack years of smoking	1.3	1.8	3.6	-0.9	1.1	-1.9
Impedance of whole body	0.2	0.8	2.3	0.2	1.5	-0.3
Leg fat mass (left)	0.3	1.4	2.6	-1.6	-0.9	0.8
Arm predicted mass (left)	0.4	2.0	3.1	-1.6	-1.8	0.6