TWAS hub - PDCD10

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.077	0.033	0.0027	0.043	NA	0.047	NA	0.048	0.00220	NA	0.00130	NA	0.00130
2	TCGA	Thyroid Carcinoma	0.081	0.063	0.0067	0.038	0.026	0.037	NA	0.036	0.00012	0.0013	0.00014	NA	0.00019

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Platelet Count	6.7	77.4	97.8	9.9	7.5
Exposure to tobacco smoke at home	6.0	6.7	7.2	2.7	2.5
Bipolar Disorder (2018)	4.6	7.3	10.4	-2.0	-3.2
Qualifications: nursing, teaching	4.6	7.2	11.0	-1.9	-3.3
Medication: Lisinopril	3.8	4.9	5.1	-2.2	2.2
Reaction Time	3.2	6.1	8.0	-2.1	-2.8
Happiness	3.2	3.9	4.2	-1.9	-2.0
Qualifications: A levels/AS levels or equivalent	3.1	6.9	10.3	-1.9	-3.2
Mean time to correctly identify matches	3.0	5.6	7.3	-2.0	-2.7
Tinnitus: Yes, now most or all of the time	3.0	3.5	6.0	-1.1	-2.4
Bipolar Disorder or Schizophrenia	2.8	6.8	12.1	-1.3	-3.5
Medication: Co-codamol	2.8	3.2	3.4	1.8	1.7
Breastfed as a baby	2.6	3.2	6.0	-0.7	-2.5
Alcohol intake versus 10 years previously	2.4	3.6	4.3	1.7	2.1
Smoking status: Current	2.4	3.9	4.9	-2.2	1.7
Prostate Cancer	2.3	3.2	3.2	1.8	1.8
Schizophrenia (2014)	2.3	5.1	10.2	-0.1	-3.2
Sensitivity / hurt feelings	2.3	4.0	4.2	-1.9	-2.1
Current tobacco smoking	2.3	3.7	5.5	-2.3	1.4
Eye problems/disorders: None of the above	2.3	2.6	3.4	1.8	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	4.2	2.0	1.1
Knee pain experienced in last month	2.3	3.6	4.2	2.1	1.7
Basal cell carcinoma (self-reported)	2.3	2.8	3.4	-1.5	-1.8
Alcohol drinker status: Previous	2.3	2.6	5.1	-0.4	-2.3
Number of live births	2.2	3.0	5.6	0.7	2.4
Qualifications: O levels/GCSEs or equivalent	2.2	3.4	4.6	-1.5	-2.2
Length of working week for main job	2.1	2.3	4.5	0.4	2.1
Glaucoma (self-reported)	2.1	2.4	3.5	1.9	-1.2
Wheeze or whistling in the chest in last year	2.1	3.8	7.5	0.3	2.7
Friendships satisfaction	2.1	2.6	3.5	-1.3	-1.9
Medication: Gliclazide	2.1	2.4	2.7	1.6	1.4
Smoking Status	2.0	4.8	9.5	-3.1	-0.4
Qualifications: None of the above	2.0	4.3	7.5	1.0	2.7
Arm fat percentage (right)	2.0	7.9	14.7	1.1	3.8
Depression (self-reported)	2.0	2.4	3.9	-2.0	-1.0
Commuting to job workplace: Cycle	2.0	2.4	2.5	-1.5	-1.6
Arm fat percentage (left)	1.9	7.4	13.1	1.3	3.6
Major Depression (MDD)	1.8	2.2	3.7	-0.9	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	3.3	-1.2	-1.8
Shortness of breath walking on level ground	1.8	2.2	4.3	0.2	2.1
Vascular/heart problems diagnosed by doctor	1.8	4.9	7.0	1.7	-2.6
Hand grip strength (left)	1.7	4.4	7.5	-2.7	-1.1
Body mass index (BMI)	1.7	7.1	14.1	0.3	3.8
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.7	1.9	0.8
Medication: Seretide 50 evohaler	1.7	1.9	3.6	-1.9	0.5
Leg pain on walking	1.7	2.2	3.8	0.8	1.9
Age at First Birth	1.6	2.3	3.7	-1.0	-1.9
Bipolar Disorder (2011)	1.6	1.6	3.2	-0.1	-1.8
Systolic blood pressure, automated reading	1.6	4.5	9.0	0.2	3.0
Vitamin and mineral supplements	1.6	2.1	4.1	-0.3	2.0
High blood pressure	1.6	4.3	5.7	-1.7	2.4
Hypertension (Self-reported)	1.6	4.4	4.5	-2.1	2.1
Breast Cancer	1.5	3.6	5.3	2.3	1.4
Cardiovascular Disease	1.5	4.9	6.3	-1.8	2.5
High blood pressure (mother)	1.5	2.1	3.8	0.6	1.9
Hair/balding pattern: Pattern 3	1.5	2.3	3.1	-1.2	-1.8
Noisy workplace	1.5	1.9	3.3	0.6	1.8
Arm fat mass (right)	1.5	6.0	12.0	0.2	3.5
Family relationship satisfaction	1.5	1.9	2.2	-1.5	-1.2
Arm fat mass (left)	1.5	6.0	11.7	0.5	3.4
Supplements: Fish oil (including cod liver oil)	1.5	2.0	3.9	-0.1	-2.0
Schizophrenia vs Biploar Disorder	1.4	1.8	2.8	1.7	0.9
Blood Eosinophil Count	1.4	10.5	10.6	3.3	3.2
Systolic Blood Pressure	1.4	7.2	14.3	-0.3	3.8
Supplements: Zinc	1.4	1.5	2.8	-0.3	-1.7
Maternal smoking around birth	1.4	2.0	2.2	-1.3	1.5
Past tobacco smoking	1.4	2.5	4.5	2.1	0.7
Chest pain or discomfort	1.4	2.0	2.7	1.1	1.6
Average weekly champagne plus white wine intake	1.4	1.9	3.8	0.2	-2.0
Commuting to job workplace: Public transport	1.4	1.7	2.0	-1.4	-1.1
Ever smoked	1.4	2.4	4.6	-2.1	-0.4
Triglycerides	1.3	2.1	3.8	-2.0	-0.6
Average weekly spirits intake	1.3	1.7	3.3	0.1	1.8
Diabetes (father)	1.3	1.7	3.3	-1.8	0.0
Average weekly fortified wine intake	1.3	1.5	2.3	1.5	-0.9
Multivitamins +/- minerals	1.3	1.7	3.2	0.4	-1.8
Medication: Cholesterol lowering	1.3	2.0	3.1	-1.8	-0.9
Gout (self-reported)	1.3	1.8	2.8	0.9	1.7
Exposure to tobacco smoke outside home	1.3	1.7	3.3	0.3	1.8
Medication for cholesterol	1.3	1.9	3.7	0.3	-1.9
Guilty feelings	1.3	2.0	3.8	0.5	1.9
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.0	0.9	1.4
Pack years adult smoking proportion	1.2	1.8	3.3	-0.6	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.8	1.7	-0.3
Number of full sisters	1.2	1.5	2.8	0.5	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.2	1.5	0.8
Supplements: Vitamin C	1.2	1.4	2.8	1.7	0.1
Ever had bowel cancer screening	1.2	1.4	2.8	-0.0	-1.7
Eye problems/disorders: Cataract	1.2	1.3	2.1	-1.5	-0.7
Diastolic blood pressure, automated reading	1.2	3.6	5.5	-1.3	2.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.4	-0.4	1.5
Hip circumference	1.1	4.5	9.0	0.3	3.0
Mouth/teeth dental problems: Dentures	1.1	1.9	3.3	-1.8	-0.6
Lung cancer (father)	1.1	1.3	2.5	1.6	-0.0
Illnesses of mother	1.1	1.3	1.8	1.3	0.9
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.3	-1.5	0.5
Body fat percentage	1.1	4.5	8.4	0.7	2.9
Mouth/teeth dental problems: Loose teeth	1.1	1.3	1.7	-0.9	-1.3
Suffer from ‘nerves’	1.1	1.7	2.0	-1.4	-1.2
Medication: Blood pressure	1.1	2.1	3.2	-1.0	1.8
Cholesterol lowering medication	1.1	1.6	2.8	0.6	1.7
Supplements: Calcium	1.1	1.2	1.8	-0.7	-1.4
Supplements: Glucosamine	1.0	1.3	2.5	0.2	-1.6
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.5	-0.2	1.6
Leg fat percentage (right)	1.0	3.5	7.0	-0.0	2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.3	-1.5	-0.6
Overall health rating	1.0	2.1	2.8	-1.2	1.7
Illnesses of father: Heart disease	1.0	1.4	1.9	0.9	1.4
Smoking status: Previous	1.0	1.4	1.9	-1.0	-1.4
Eye problems/disorders: Glaucoma	1.0	1.2	2.0	0.6	-1.4
Pack years of smoking	1.0	1.5	2.7	-0.6	1.6
Respiratory disease	0.9	2.1	3.9	-2.0	-0.5
Trunk fat percentage	0.9	3.7	6.5	0.9	2.6
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.0	-1.4	-0.1
Prospective memory result	0.9	1.1	1.7	-1.3	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	1.7	-1.3	1.0
Medication: Amlodipine	0.9	1.3	2.6	0.0	1.6
High blood pressure (siblings)	0.9	1.4	2.7	-1.6	-0.0
Age at first live birth	0.9	1.5	3.0	-0.2	-1.7
Whole body fat mass	0.9	3.6	7.2	-0.0	2.7
Leg fat mass (right)	0.9	3.4	6.9	-0.2	2.6
Mineral and other dietary supplements	0.9	1.2	2.5	0.0	1.6
Medication: Aspirin	0.9	1.2	1.9	-1.4	0.7
Number of self-reported non-cancer illnesses	0.9	1.6	2.7	-1.7	0.7
Leg fat percentage (left)	0.9	3.2	6.4	-0.3	2.5
Leg fat mass (left)	0.9	3.3	6.6	-0.3	2.6
Schizophrenia (2018)	0.8	1.7	3.4	0.0	-1.9
Mean Putamen Volume	0.8	0.9	1.7	-0.4	-1.3
BMI	0.8	4.8	9.5	0.3	3.1
Allergy or Eczema	0.8	2.1	3.8	-0.5	-2.0
Waist circumference	0.8	2.9	5.9	-0.1	2.4
Hair/balding pattern: Pattern 2	0.8	1.0	1.8	-0.4	1.4
Had menopause	0.8	1.1	1.2	1.1	1.0
Tense / ‘highly strung’	0.8	1.4	1.4	-1.2	-1.1
Comparative height size at age 10	0.8	4.2	4.7	-1.9	-2.2
Medication: Aspirin	0.8	1.1	1.5	-1.2	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.8	1.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	2.3	-1.0	-1.5
Hearing aid user	0.8	1.0	1.4	1.2	0.7
Illnesses of father: High blood pressure	0.8	1.0	2.0	-0.0	1.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.8	0.1	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.8	-0.5	-1.4
Ovarian Cancer	0.7	0.9	1.0	1.0	0.9
LDL Cholesterol	0.7	1.1	1.3	-0.9	-1.2
Neuroticism (2016)	0.7	1.0	1.6	-1.3	-0.6
Heel T-Score	0.7	5.9	6.4	-2.5	-2.4
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.6	-0.2	1.6
Impedance of leg (left)	0.7	3.4	6.6	-0.5	-2.6
Number of incorrect matches in round	0.7	1.1	2.1	-1.4	-0.5
Pulse wave Arterial Stiffness index	0.7	0.9	1.7	-0.2	-1.3
Impedance of arm (left)	0.7	3.3	5.9	2.4	-0.8
Headache pain in last month	0.7	1.2	1.4	-1.2	-1.0
Forced vital capacity (FVC), Best measure	0.7	2.5	3.2	-1.3	-1.8
Comparative body size at age 10	0.7	1.9	2.5	-1.2	1.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.5	1.2	-0.3
Wears glasses or contact lenses	0.7	0.8	1.1	-0.8	-1.0
Irritability	0.7	1.2	1.4	-1.2	-1.0
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	-1.2	-0.2
Primary Biliary Cirrhosis	0.6	0.9	1.6	-1.3	-0.4
Blood White Count	0.6	4.5	8.4	0.7	2.9
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.4	-1.2	-0.6
Impedance of leg (right)	0.6	2.9	5.8	-0.1	-2.4
Chronic bronchitis/emphysema (father)	0.6	0.7	1.3	-1.1	-0.1
Alcohol usually taken with meals	0.6	1.0	1.8	0.4	-1.3
Medication: Simvastatin	0.6	0.8	0.9	-0.9	0.9
Weight	0.6	3.0	5.9	-0.5	2.4
Time employed in main current job	0.6	0.7	1.4	0.1	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.1	-1.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	2.5	-1.2	-1.6
Standing height	0.6	5.5	7.4	-1.9	-2.7
Birth weight	0.6	1.4	2.1	-1.4	-0.8
Number of full brothers	0.6	0.7	1.0	-1.0	0.7
Number of children fathered	0.6	0.6	0.9	-1.0	0.6
Qualifications: College or University degree	0.6	1.8	3.5	0.3	-1.9
Alcohol intake frequency.	0.6	1.3	1.8	0.9	1.3
Had major operations	0.6	0.7	1.3	1.1	-0.4
Mood swings	0.6	1.1	1.1	-1.0	-1.0
Diabetes diagnosed by doctor	0.6	1.0	2.1	0.1	1.4
Osteoarthritis (self-reported)	0.6	0.8	1.4	-0.3	-1.2
Financial situation satisfaction	0.6	0.7	0.8	-0.9	0.8
Medication: Bendroflumethiazide	0.6	0.9	1.7	-0.0	1.3
Myopia	0.6	0.8	1.5	-0.4	-1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	-1.2	0.2
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.8	0.6	0.9
Angina	0.5	0.7	1.2	-0.3	1.1
Medication: Metformin	0.5	0.7	1.0	-1.0	0.7
Trunk fat mass	0.5	2.2	4.5	0.2	2.1
Hearing difficulty/problems with background noise	0.5	0.8	1.0	1.0	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.3	-0.3	-1.5
Diabetes (self-reported)	0.5	0.8	1.6	-0.3	1.2
Impedance of arm (right)	0.5	2.3	4.2	2.0	-0.7
Father’s age at death	0.5	0.7	0.9	-0.7	-1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	0.9	0.9	-0.9
Pulse wave peak to peak time	0.5	0.6	1.2	0.1	1.1
Medication for pain relief, constipation, heartburn	0.5	0.9	1.0	0.9	-1.0
Angina (self-reported)	0.5	0.7	1.3	-0.2	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.9	-0.9	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	0.7	-0.7	0.8
Pain experienced in last month	0.5	0.8	1.0	-0.7	-1.0
Heart disease (siblings)	0.5	0.7	1.3	-0.2	1.1
Impedance of whole body	0.5	2.5	3.8	1.1	-1.9
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.6	0.5	-1.3
Rheumatoid Arthritis	0.4	0.5	0.5	0.7	0.7
Waist Hip Ratio (WHR)	0.4	1.8	1.9	-1.4	-1.3
Number of treatments/medications taken	0.4	0.8	1.3	-0.5	1.1
Hand grip strength (right)	0.4	1.1	2.2	-1.5	-0.1
Townsend deprivation index at recruitment	0.4	0.6	0.8	-0.9	0.6
Financial difficulties in last 2 years	0.4	0.5	0.9	-0.4	1.0
Illnesses of siblings	0.4	0.5	0.7	0.9	-0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.0	0.7	-1.0
Health satisfaction	0.4	0.5	0.8	-0.9	0.5
Medication: Blood pressure	0.4	0.7	0.8	-0.9	0.8
Long-standing illness, disability or infirmity	0.4	0.6	0.7	-0.8	0.7
Breast cancer (self-reported)	0.4	0.5	1.0	0.1	-1.0
Arm fat-free mass (left)	0.4	2.0	3.1	-1.8	0.9
Average weekly beer plus cider intake	0.4	0.5	1.0	-0.2	1.0
Ever depressed for a whole week	0.4	0.5	0.6	0.7	0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	1.0	-1.0	-0.1
Crohns Disease (2012)	0.3	0.5	0.8	-0.9	-0.6
Blood Red Count	0.3	3.3	3.4	1.8	1.8
Neuroticism	0.3	0.8	1.4	-0.4	-1.2
Hearing difficulty/problems: Yes	0.3	0.5	0.5	0.7	0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.6	-0.4	0.7
Leg fat-free mass (left)	0.3	1.5	2.8	-0.3	1.7
Fed-up feelings	0.3	0.6	0.9	-0.9	-0.6
Relative age voice broke	0.3	0.5	0.8	-0.9	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.5	-0.1	-1.2
Qualifications: CSEs or equivalent	0.3	0.4	0.8	-0.9	-0.1
Serious illness, injury or assault to yourself	0.3	0.3	0.4	0.5	0.6
Medication: Atenolol	0.3	0.4	0.4	-0.6	0.6
Medication: Levothyroxine sodium	0.3	0.5	1.0	1.0	-0.0
Leg predicted mass (left)	0.3	1.6	3.2	-0.1	1.8
Heart attack	0.3	0.4	0.7	-0.8	0.4
Medication: Ramipril	0.3	0.4	0.5	-0.7	0.4
Trunk fat-free mass	0.3	1.6	3.1	-1.8	-0.1
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	-0.4	-0.7
Medication: Allopurinol	0.3	0.4	0.8	0.3	0.9
Arm predicted mass (right)	0.3	1.6	3.1	-1.8	0.2
Average weekly red wine intake	0.3	0.4	0.6	0.8	-0.3
Illnesses of father: None of the above (group 1)	0.3	0.3	0.5	0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.3	-0.5	-1.1
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.4	-0.6	-0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.9	0.3
Arm predicted mass (left)	0.3	1.7	2.5	-1.6	1.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	0.9	0.7	-0.9
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.5	-0.3
Ever had hysterectomy (womb removed)	0.2	0.2	0.2	0.5	0.4
Age when periods started (menarche)	0.2	0.6	1.0	1.0	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.7	0.5	-0.8
Allergy	0.2	0.5	0.7	0.4	0.9
Pain all over the body in last month	0.2	0.2	0.2	0.5	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.4	0.3	-0.7
Asthma	0.2	0.4	0.7	-0.8	0.3
Trunk predicted mass	0.2	1.4	2.7	-1.6	0.1
Birth weight of first child	0.2	0.3	0.5	0.7	-0.3
Pulse wave reflection index	0.2	0.2	0.4	-0.3	-0.7
Blood clot in the leg (DVT)	0.2	0.2	0.4	0.6	0.3
Arm fat-free mass (right)	0.2	1.2	2.4	-1.6	0.2
Pulse rate, automated reading	0.2	0.7	0.8	-0.9	-0.8
Whole body fat-free mass	0.2	0.9	1.4	-1.2	0.7
Leg fat-free mass (right)	0.2	1.3	2.5	-0.4	1.6
Loneliness, isolation	0.2	0.2	0.4	0.6	0.1
Asthma (self-reported)	0.2	0.4	0.8	-0.9	0.2
Whole body water mass	0.2	1.0	1.6	-1.2	0.7
Leg predicted mass (right)	0.2	1.2	2.3	-0.4	1.5
Mother’s age at death	0.2	0.3	0.4	0.7	0.4
High cholesterol (Self-reported)	0.2	0.3	0.4	-0.6	0.5
Medication: Atorvastatin	0.2	0.2	0.5	-0.7	0.0
Alcohol drinker status: Never	0.2	0.2	0.3	0.6	-0.3
Basal metabolic rate	0.2	1.2	1.5	-1.0	1.2
Number of operations (self-reported)	0.2	0.2	0.4	0.4	-0.6
Age started oral contraceptive pill	0.2	0.3	0.5	0.7	0.1
Depression (Nagel 2018)	0.1	0.2	0.3	-0.3	-0.5
Worry (Nagel 2018)	0.1	0.3	0.3	0.5	0.5
Ulcerative Colitis (UC)	0.1	0.2	0.2	0.4	-0.5
Fasting Glucose	0.1	0.1	0.1	0.0	0.4
Lupus	0.1	0.2	0.4	0.6	0.2
Ulcerative Colitis	0.1	0.1	0.2	-0.4	-0.3
Height	0.1	2.9	3.6	-1.5	-1.9
Hypothyroidism (self reported)	0.1	0.3	0.4	0.7	-0.5
Lung FEV1/FVC ratio	0.1	0.3	0.5	-0.7	0.3
Lung FVC	0.1	0.4	0.4	-0.6	-0.6
Chronotype (morning person)	0.1	0.3	0.6	0.2	0.8
Hair Pigment	0.1	4.2	6.7	2.6	1.3
Tanning	0.1	1.6	2.9	-0.5	-1.7
Relative age of first facial hair	0.1	0.1	0.2	0.2	-0.5
Medication for hormone replacement therapy	0.1	0.1	0.2	0.5	0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.4	0.3
Sitting height	0.1	0.9	1.6	-1.2	-0.4
Had other major operations	0.1	0.1	0.2	0.5	-0.0
Forced vital capacity (FVC)	0.1	0.4	0.5	-0.7	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.2	0.5
Mouth/teeth dental problems	0.1	0.1	0.2	0.5	-0.1
Fluid intelligence score	0.1	0.3	0.6	0.1	-0.8
Neuroticism score	0.1	0.2	0.2	-0.4	-0.4
Worrier / anxious feelings	0.1	0.1	0.2	-0.2	0.4
Falls in the last year	0.1	0.1	0.3	0.5	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.3	-0.5	-0.5
Pulse rate	0.1	0.2	0.4	-0.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.3	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.1	0.5
Medication: Lansoprazole	0.1	0.1	0.1	-0.3	0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.5	0.4
Medication: Paracetamol	0.1	0.2	0.3	0.6	0.4
Worry too long after embarrassment	0.1	0.1	0.1	-0.2	0.4
Emphysema/chronic bronchitis	0.1	0.2	0.2	-0.4	0.3
Neck or shoulder pain in last month	0.1	0.2	0.3	-0.6	0.3
Migraine (self-reported)	0.1	0.2	0.3	-0.5	-0.2
Medication: Omeprazole	0.1	0.1	0.2	0.0	-0.4
Age at last live birth	0.1	0.1	0.2	-0.3	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.4	-0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.1	-0.1	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	-0.3	0.5
Commuting to job workplace: Walk	0.1	0.1	0.2	0.5	0.1
Back pain experienced in last month	0.1	0.2	0.2	0.5	0.4
Miserableness	0.1	0.1	0.2	0.4	0.2
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.2	0.5
Medication: Paracetamol	0.1	0.1	0.1	-0.4	0.3
Risk taking	0.1	0.1	0.3	0.1	-0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.1	0.4	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	0.5	0.2
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	-0.1	-0.1
Neuroticism (Nagel 2018)	0.0	0.1	0.1	-0.3	0.3
Crohns Disease (2017)	0.0	0.1	0.1	0.0	0.4
Irritable Bowel Disease (IBD)	0.0	0.0	0.0	0.1	-0.2
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	-0.3	0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	-0.2	0.1
HbA1C	0.0	0.1	0.1	0.3	-0.2
HDL Cholesterol	0.0	0.1	0.1	0.3	-0.2
Diabetes (mother)	0.0	0.1	0.1	0.1	0.3
Severe depression (siblings)	0.0	0.0	0.0	-0.1	-0.2
Taking other prescription medications	0.0	0.1	0.1	0.0	0.4
Stomach or abdominal pain in last month	0.0	0.0	0.1	0.1	-0.3
Nervous feelings	0.0	0.1	0.2	0.4	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.1	0.2
Peak expiratory flow (PEF)	0.0	0.0	0.0	0.0	0.1
Loud music exposure frequency	0.0	0.1	0.1	0.2	0.3
Medication: Ibuprofen	0.0	0.0	0.0	-0.1	-0.1
Heart disease (mother)	0.0	0.0	0.0	-0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	-0.2	-0.3
Osteoporosis (self-reported)	0.0	0.0	0.1	-0.3	-0.2
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.2	-0.2

Hub : Genes

PDCD10

Models

Trait associations