TWAS hub - PDE7A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Stomach	0.1290	0.0530	0.0034	-0.003	NA	-0.006	NA	-0.001	4.8e-01	NA	0.92000	NA	0.35000
2	GTEx	Thyroid	0.1110	0.0420	0.0015	0.060	NA	0.038	NA	0.043	2.3e-05	NA	0.00066	NA	0.00029
3	YFS	Blood	0.0271	0.0123	0.0051	0.001	0.007	0.000	0.009	0.000	9.4e-02	0.0012	0.35000	0.00042	0.24000
4	TCGA	Thyroid Carcinoma	0.0280	0.0170	0.0058	-0.001	0.013	0.000	NA	-0.001	4.5e-01	0.0190	0.35000	NA	0.38000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Fluid intelligence score	4.9	10.1	18.1	4.2	1.3	3.2	-3.3
Breastfed as a baby	3.5	4.3	8.8	3.0	0.6	1.6	-2.4
Smoking Status	3.3	7.9	21.2	2.6	0.8	-1.7	-4.6
Intelligence (Savage-Jansen 2018)	3.2	9.8	23.8	4.9	1.0	1.4	-3.5
Tinnitus: Yes, now most or all of the time	3.2	3.7	10.4	1.9	-0.8	0.5	-3.2
Verbal and Numeric Reasoning (VNR)	3.0	7.3	14.3	3.8	1.5	2.6	-2.4
HbA1C	2.9	3.3	7.0	-1.2	-1.9	-2.7	0.9
Medication: Levothyroxine sodium	2.8	4.8	14.6	1.0	1.1	3.8	-1.6
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	4.4	2.1	1.9	1.2	-1.9
Supplements: Glucosamine	2.7	3.6	6.8	2.2	2.6	1.5	-0.6
Medication for pain relief, constipation, heartburn	2.7	4.6	10.5	2.6	1.1	3.2	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.2	8.1	-1.5	-2.8	-1.0	1.1
Multivitamins +/- minerals	2.6	3.3	10.8	3.3	0.7	-0.1	-1.3
Past tobacco smoking	2.6	4.8	15.4	-1.3	0.2	1.4	3.9
Medication: Paracetamol	2.6	4.0	9.2	-3.0	-1.3	-1.5	1.6
Smoking status: Previous	2.3	3.5	10.9	1.2	-0.2	-1.3	-3.3
Back pain experienced in last month	2.3	3.3	10.5	-3.2	-1.2	0.4	1.0
Medication: Paracetamol	2.2	3.6	6.1	-2.5	-0.4	-2.1	1.9
Diverticular disease/diverticulitis (self-reported)	2.1	2.4	6.7	-0.7	-1.6	0.0	-2.6
Mouth/teeth dental problems: Dentures	2.1	3.5	6.6	0.7	1.9	2.6	-1.8
Number of children fathered	2.1	2.4	8.1	-2.8	-0.7	0.6	-0.8
Medication: Atorvastatin	2.1	2.6	6.4	-1.2	-2.5	1.5	-0.5
Average weekly spirits intake	2.0	2.4	7.7	1.2	-0.5	2.8	-0.6
Age when periods started (menarche)	2.0	4.7	6.7	-2.6	-1.7	-1.6	2.6
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	7.3	0.7	1.1	2.7	-2.6
Ovarian Cancer	1.9	2.6	6.9	1.0	1.4	2.6	-0.5
Vitamin and mineral supplements	1.9	2.5	7.4	-2.7	-0.4	0.6	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	8.0	0.2	1.3	2.8	-0.7
Migraine (self-reported)	1.9	2.3	5.3	-1.5	-0.3	-2.3	1.3
Major Depression (MDD)	1.8	2.2	5.4	1.5	-0.6	-0.8	-2.3
Taking other prescription medications	1.8	2.8	8.7	0.3	-1.4	0.5	-3.0
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	5.7	-0.5	0.8	-1.0	2.4
Heart attack	1.8	2.3	7.9	0.4	-0.2	2.8	-1.0
Depression (Nagel 2018)	1.7	2.5	8.2	-1.0	0.9	2.9	0.3
Blood Platelet Count	1.7	20.0	59.8	1.5	-3.9	-1.6	-7.7
Fed-up feelings	1.7	3.1	6.4	-2.3	-0.7	-0.3	2.5
Hypothyroidism (self reported)	1.6	3.6	7.6	0.6	1.3	2.2	-2.8
Number of treatments/medications taken	1.6	2.8	4.5	-1.6	-2.1	-1.1	-1.7
Number of incorrect matches in round	1.6	2.7	5.5	-1.0	2.0	0.6	2.3
Friendships satisfaction	1.6	2.0	4.5	0.6	1.5	2.1	1.0
Wears glasses or contact lenses	1.6	1.9	5.4	0.8	0.3	1.2	-2.3
Depressed Affect (Nagel 2018)	1.5	3.1	4.6	-2.1	1.4	1.6	1.8
Body Mass Index (BMI) (2010)	1.5	2.0	6.4	-0.6	2.5	-0.5	1.0
Blood Eosinophil Count	1.5	11.6	28.9	-0.5	-4.1	-0.7	-5.4
Pulse rate, automated reading	1.5	4.9	12.0	1.0	-1.6	-2.0	-3.5
Leg pain on walking	1.5	1.9	3.6	-1.9	-1.9	-0.7	0.2
Breast cancer (self-reported)	1.5	1.8	4.0	-1.4	-2.0	-0.5	1.0
Schizophrenia vs Biploar Disorder	1.4	1.8	3.3	-1.8	-1.8	0.1	0.9
Blood White Count	1.4	10.7	24.5	-1.9	-5.0	-3.8	-0.7
Impedance of arm (right)	1.4	6.3	11.4	2.3	-1.1	2.7	-3.4
Happiness	1.4	1.7	4.3	0.1	1.5	0.2	2.1
Hearing aid user	1.4	1.6	6.1	0.1	-0.3	2.5	-0.5
Ever had prostate specific antigen (PSA) test	1.4	1.7	3.5	1.0	1.3	0.7	-1.9
Pain experienced in last month	1.4	2.4	5.7	2.4	1.4	-0.6	-1.2
Heart attack/myocardial infarction (self-reported)	1.4	1.9	6.2	0.2	-0.3	2.5	-1.1
Townsend deprivation index at recruitment	1.3	1.8	3.6	1.7	-0.4	-0.5	-1.9
Health satisfaction	1.3	1.7	6.3	-2.5	-0.2	0.7	-0.3
Mean time to correctly identify matches	1.3	2.6	5.1	0.5	1.2	1.9	-2.2
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	4.5	1.1	-2.1	0.3	-0.4
Osteoarthritis (self-reported)	1.3	1.6	4.2	1.2	0.8	2.1	-0.3
Mother’s age at death	1.3	1.6	4.3	-0.8	-2.1	-1.0	0.6
Myopia	1.3	1.9	3.7	1.2	1.3	-0.7	1.9
Primary Biliary Cirrhosis	1.2	1.7	5.7	-2.4	-0.2	-0.3	1.0
Sensitivity / hurt feelings	1.2	2.0	4.2	-2.0	-1.1	-1.4	0.9
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	5.6	0.6	-0.3	0.3	-2.4
Ever used hormone-replacement therapy (HRT)	1.2	1.6	4.0	0.5	-2.0	0.7	-1.2
Current tobacco smoking	1.2	2.0	3.5	1.9	1.4	0.4	-1.5
Chronic bronchitis/emphysema (father)	1.2	1.4	3.8	-1.1	-1.9	-0.5	-0.7
Had menopause	1.2	1.5	2.1	1.3	1.2	0.8	-1.5
Alcohol intake versus 10 years previously	1.2	1.8	4.2	-0.7	-2.0	-0.9	1.3
Falls in the last year	1.2	1.6	3.8	-1.9	-1.2	0.6	1.0
Pulse rate	1.2	2.0	3.8	0.8	-0.2	-1.9	-2.0
Loud music exposure frequency	1.2	1.4	2.0	1.4	1.2	1.3	-0.6
Smoking status: Current	1.2	1.9	3.4	1.8	1.4	0.4	-1.5
Miserableness	1.2	2.1	5.2	0.6	1.7	2.3	0.1
Guilty feelings	1.2	1.8	6.9	-0.1	-0.6	-0.2	2.6
Financial situation satisfaction	1.2	1.4	2.9	0.3	1.7	0.8	1.5
Eye problems/disorders: Glaucoma	1.2	1.4	2.4	-1.4	-1.5	-1.1	0.3
Blood Red Count	1.1	10.5	24.5	-1.0	-3.7	-1.6	-5.0
Chronotype (morning person)	1.1	2.4	4.3	-2.1	-0.6	-1.1	2.0
Serious illness, injury or assault to yourself	1.1	1.3	3.8	-0.2	-0.8	0.9	-1.9
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	4.6	0.4	2.1	-0.7	0.2
Qualifications: None of the above	1.1	2.4	6.1	-2.5	0.9	0.2	1.6
Diabetes (self-reported)	1.1	1.7	5.6	-2.4	-0.7	-0.5	0.6
Impedance of arm (left)	1.1	5.1	8.5	2.4	-1.2	2.1	-2.9
Peak expiratory flow (PEF)	1.1	2.6	6.2	-1.9	0.2	-0.9	2.5
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.2	2.3	-1.1	0.5	-0.7
Forced vital capacity (FVC), Best measure	1.1	3.9	11.1	-0.4	-1.9	-0.8	3.3
Pulse wave peak to peak time	1.1	1.3	2.4	0.1	0.8	1.6	1.5
Chest pain or discomfort	1.1	1.5	5.1	-0.7	-0.6	-0.3	-2.3
Mineral and other dietary supplements	1.1	1.5	3.6	-1.9	-1.3	-0.4	0.6
Number of self-reported non-cancer illnesses	1.1	1.9	3.1	-1.8	-0.8	1.1	-1.6
Medication: Co-codamol	1.0	1.1	1.9	-1.4	-1.2	-0.8	-0.8
Medication: Atenolol	1.0	1.2	3.2	-1.8	-0.2	-0.1	-1.3
Pain all over the body in last month	1.0	1.0	2.1	-1.3	-1.5	-0.2	0.6
Worrier / anxious feelings	1.0	1.9	6.4	-0.6	-2.5	0.5	0.8
Hair/balding pattern: Pattern 3	1.0	1.4	3.6	0.7	1.1	1.9	0.6
Noisy workplace	1.0	1.2	3.5	-0.2	0.8	-1.9	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.3	-0.7	-1.0	0.3	-2.1
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.0	0.5	0.6	1.3	-1.7
Angina (self-reported)	1.0	1.3	3.1	0.3	0.6	1.3	-1.8
Medication: Omeprazole	1.0	1.2	3.3	-1.8	-0.7	0.1	-1.0
Mood swings	1.0	1.8	4.0	-1.3	0.2	1.3	2.0
Average weekly champagne plus white wine intake	1.0	1.4	4.8	-0.0	0.9	0.1	-2.2
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.7	-0.5	1.0	1.9	0.2
Neuroticism (Nagel 2018)	0.9	2.0	4.5	-1.4	0.6	1.2	2.1
Reaction Time	0.9	1.7	4.0	0.9	1.1	0.9	-2.0
Triglycerides	0.9	1.5	3.4	-1.9	-0.5	-0.9	1.3
Angina	0.9	1.2	2.3	0.5	0.4	1.4	-1.5
Hand grip strength (right)	0.9	2.5	4.0	2.0	1.3	-0.8	1.9
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	3.7	0.6	-0.1	0.8	-1.9
Qualifications: A levels/AS levels or equivalent	0.9	1.9	5.4	2.3	0.0	1.4	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.0	-0.4	0.7	-1.4	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	8.4	-1.0	-1.6	0.1	2.9
Pulse wave Arterial Stiffness index	0.9	1.0	1.9	0.0	-0.8	-1.3	-1.4
Hair/balding pattern: Pattern 4	0.9	2.2	5.1	-2.3	-1.8	-0.5	-0.1
Birth weight of first child	0.9	1.6	6.1	0.4	0.5	-0.0	-2.5
Medication: Ibuprofen	0.9	1.0	2.3	-0.7	-0.1	-1.5	1.2
Age at last live birth	0.9	1.3	2.8	0.8	1.7	1.3	-0.4
Illnesses of siblings: Diabetes	0.9	1.1	2.2	1.5	1.2	-0.3	-0.8
Ever had bowel cancer screening	0.9	1.1	4.2	-0.2	0.2	0.3	-2.1
Illnesses of father: High blood pressure	0.9	1.1	2.8	0.9	-0.1	-0.8	-1.7
Alcohol drinker status: Never	0.9	1.1	3.2	0.8	1.8	0.3	0.6
Ever smoked	0.9	1.5	4.3	0.6	-0.6	-1.0	-2.1
Ever depressed for a whole week	0.9	1.1	3.0	0.9	1.7	-0.3	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.4	-1.6	-0.8	-0.1	-1.1
Impedance of whole body	0.9	4.5	7.1	2.5	-0.5	2.1	-2.7
Fasting Glucose	0.8	0.9	1.9	-0.9	-0.1	-1.4	1.0
HDL Cholesterol	0.8	1.4	3.8	0.8	-0.6	1.9	-0.9
Rheumatoid Arthritis	0.8	1.1	3.4	0.8	-0.3	-0.5	-1.8
Ulcerative Colitis	0.8	1.1	2.4	-1.5	-0.7	-0.1	1.3
Neuroticism	0.8	1.9	3.9	-0.6	0.1	2.0	1.9
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.8	0.1	0.5	1.7	1.2
Trunk fat percentage	0.8	3.1	7.6	-0.8	-1.8	-0.9	-2.8
Maternal smoking around birth	0.8	1.1	3.3	-1.8	0.1	-1.1	-0.3
High blood pressure (mother)	0.8	1.1	3.3	-1.8	-0.7	0.2	-0.9
Mouth/teeth dental problems	0.8	1.2	2.5	-0.5	-0.6	-1.3	1.6
Illnesses of siblings	0.8	1.2	3.7	-0.5	0.1	0.8	1.9
Time employed in main current job	0.8	0.9	3.2	-0.5	1.8	0.3	0.1
Tense / ‘highly strung’	0.8	1.3	3.5	-0.5	0.8	0.9	1.9
Number of full sisters	0.8	1.0	2.5	-0.8	0.9	-1.6	-0.1
Loneliness, isolation	0.8	1.1	2.5	-0.6	0.9	1.6	1.0
Illnesses of father: None of the above (group 1)	0.8	0.9	2.9	-0.4	-0.5	1.7	0.6
Ever taken oral contraceptive pill	0.8	0.9	1.9	-1.4	-0.4	-1.2	0.5
Age started oral contraceptive pill	0.8	1.0	1.4	0.7	-1.2	0.8	-1.2
Bipolar Disorder (2018)	0.7	1.1	2.5	0.7	1.6	-0.6	-1.1
Worry (Nagel 2018)	0.7	1.4	4.2	-0.7	-0.6	0.7	2.0
Lupus	0.7	1.1	3.4	-0.5	0.3	-0.8	1.8
Qualifications: CSEs or equivalent	0.7	1.0	2.4	-1.0	-0.6	-1.5	-0.0
Stomach or abdominal pain in last month	0.7	0.9	1.5	-1.0	-1.1	0.2	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.2	0.1	1.1	1.5	1.0
Forced vital capacity (FVC)	0.7	2.6	9.1	0.4	-1.1	-0.2	3.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	8.0	-0.5	-1.0	0.6	2.8
Prospective memory result	0.7	0.9	2.6	-1.6	0.6	-0.8	-0.2
Illnesses of mother	0.7	0.9	1.5	0.8	-0.9	-1.2	0.7
Gout (self-reported)	0.7	1.0	3.1	1.0	1.8	0.2	0.1
Birth weight	0.7	1.5	5.9	0.4	0.2	-0.1	-2.4
Body fat percentage	0.7	2.7	7.0	-0.7	-1.5	-1.1	-2.6
Exposure to tobacco smoke outside home	0.7	0.9	1.5	-1.2	-0.6	-0.8	1.1
Emphysema/chronic bronchitis	0.7	0.8	3.0	-0.3	-0.0	1.7	0.0
Knee pain experienced in last month	0.7	1.0	2.2	-0.6	-1.1	-0.5	1.5
Long-standing illness, disability or infirmity	0.7	1.1	4.0	0.2	-0.7	0.0	-2.0
Qualifications: nursing, teaching	0.7	1.1	2.1	1.2	-0.7	0.5	-1.4
Heart disease (siblings)	0.7	0.8	2.1	-1.4	-0.7	0.0	-0.9
Bipolar Disorder or Schizophrenia	0.6	1.4	4.8	-0.1	0.7	-0.3	-2.2
Breast Cancer	0.6	1.5	5.0	0.2	2.2	-0.9	0.5
Bipolar Disorder (2011)	0.6	0.6	1.1	-0.6	0.9	-0.4	-1.0
Coronary Artery Disease (CAD)	0.6	0.8	1.4	0.5	0.3	1.1	-1.2
Waist Hip Ratio (WHR)	0.6	2.6	7.6	-1.0	-0.7	1.1	-2.8
Diabetes (mother)	0.6	0.8	1.6	-1.3	-0.7	0.8	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	1.3	1.1	-0.4	-0.0
Impedance of leg (left)	0.6	2.8	4.6	2.0	0.7	1.5	-2.1
Waist circumference	0.6	2.3	3.1	-1.7	-1.8	-1.3	-1.2
Had other major operations	0.6	0.7	1.8	-0.2	-0.6	0.8	-1.3
Medication: Ramipril	0.6	0.7	1.5	0.2	-0.1	-1.2	-1.2
Arm fat percentage (right)	0.6	2.3	6.2	-0.6	-1.5	-0.6	-2.5
Father’s age at death	0.6	0.8	1.1	0.8	0.8	1.1	-0.9
Depression (self-reported)	0.6	0.8	2.5	0.5	-1.6	0.6	-0.1
Headache pain in last month	0.6	1.0	1.3	-1.1	-1.2	-0.7	1.0
Eye problems/disorders: None of the above	0.6	0.7	1.2	0.6	1.1	-0.2	1.1
Suffer from ‘nerves’	0.6	0.9	3.5	-0.1	-0.3	-0.2	1.9
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.4	-0.9	-0.6	-1.2	0.3
Commuting to job workplace: Walk	0.6	0.6	1.0	1.0	-0.9	0.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.3	-1.8	-0.6	0.6	1.1
Commuting to job workplace: Public transport	0.6	0.7	2.0	1.4	-0.7	0.3	-0.3
Medication: Bendroflumethiazide	0.6	0.9	1.5	-1.2	0.9	-0.9	0.6
Average weekly beer plus cider intake	0.6	0.8	1.6	0.7	1.3	-0.5	-1.0
Schizophrenia (2018)	0.5	1.1	3.6	-0.7	-0.3	-0.0	-1.9
Age at First Birth	0.5	0.8	1.3	0.9	-1.1	-0.2	1.1
Mean Putamen Volume	0.5	0.6	1.2	0.6	0.8	0.5	1.1
Systolic Blood Pressure	0.5	2.6	6.6	-0.2	-1.9	-2.6	-0.4
Lung FVC	0.5	2.4	4.9	-1.1	-1.8	-0.0	2.2
Hand grip strength (left)	0.5	1.4	4.1	1.0	0.6	-0.6	2.0
Relative age of first facial hair	0.5	1.1	1.5	-1.2	-0.3	-1.1	1.2
Ever had hysterectomy (womb removed)	0.5	0.5	0.8	0.9	0.6	-0.8	-0.4
Systolic blood pressure, automated reading	0.5	1.4	3.6	-0.5	-1.4	-1.9	-0.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.9	-0.7	-0.8	-0.1	-1.0
Relative age voice broke	0.5	0.7	1.5	0.2	1.2	-0.3	1.2
Body mass index (BMI)	0.5	2.2	3.8	-1.9	-1.2	-1.9	-0.3
Trunk fat mass	0.5	2.3	5.0	-0.7	-1.5	-1.2	-2.2
Medication: Simvastatin	0.5	0.7	1.8	0.9	1.3	-0.6	-0.3
Hip circumference	0.5	2.3	4.5	-1.4	-2.1	-1.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.6	0.5	0.5	1.1	1.3
Medication: Lansoprazole	0.5	0.6	1.5	-0.3	-1.2	-0.6	-0.6
Lung cancer (father)	0.5	0.6	1.5	0.8	0.3	-1.2	-0.3
Arm fat mass (right)	0.5	2.1	2.4	-1.2	-1.5	-1.5	-1.6
Exposure to tobacco smoke at home	0.5	0.6	1.4	0.7	-0.0	-1.2	0.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	-0.4	1.1	0.7	-0.8
Blood clot in the leg (DVT)	0.5	0.7	1.7	0.1	1.3	0.9	0.2
Leg fat percentage (right)	0.5	2.0	3.8	-0.9	-0.9	-1.6	-1.9
Qualifications: College or University degree	0.5	1.7	4.3	2.1	0.0	-0.1	-1.5
Medication: Seretide 50 evohaler	0.5	0.5	1.2	0.2	0.5	1.1	0.8
Whole body fat mass	0.5	2.1	3.6	-0.8	-1.4	-1.5	-1.9
Leg fat mass (right)	0.5	1.9	3.6	-1.0	-1.0	-1.9	-1.3
Arm fat percentage (left)	0.5	2.0	4.8	-0.3	-1.5	-0.9	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	0.3	-0.7	1.0	-0.7
Leg fat percentage (left)	0.5	1.7	4.4	-0.4	-0.3	-1.5	-2.1
Number of operations (self-reported)	0.5	0.8	1.7	-0.0	-1.1	0.3	-1.3
Diastolic blood pressure, automated reading	0.5	1.5	2.2	-1.5	-1.5	-1.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.1	0.2	1.4	0.6	0.3
Alcohol drinker status: Previous	0.5	0.5	1.5	0.2	0.8	-0.2	-1.2
Alzheimer’s Disease (in father)	0.4	0.4	1.3	-0.1	0.5	-1.1	0.4
Crohns Disease (2017)	0.4	0.9	2.3	-0.1	1.1	0.5	-1.5
Ulcerative Colitis (UC)	0.4	0.7	2.8	-1.7	-0.3	-0.3	-0.0
Crohns Disease (2012)	0.4	0.6	1.6	-1.3	0.7	0.4	-0.0
Schizophrenia (2014)	0.4	0.9	3.2	-0.3	0.0	-0.5	-1.8
BMI	0.4	2.4	5.2	-2.1	0.3	-2.3	-0.1
Cardiovascular Disease	0.4	1.4	2.7	0.8	0.1	-1.6	-1.5
Lung FEV1/FVC ratio	0.4	1.9	3.9	-2.0	0.1	1.8	-0.8
Severe depression (siblings)	0.4	0.4	1.4	0.4	0.1	0.1	-1.2
Pack years adult smoking proportion	0.4	0.6	1.9	0.6	0.2	-1.4	-0.2
Alcohol usually taken with meals	0.4	0.7	1.9	0.2	-0.5	0.7	1.4
Hair/balding pattern: Pattern 2	0.4	0.6	0.8	0.9	-0.9	-0.5	-0.6
Financial difficulties in last 2 years	0.4	0.6	2.1	0.4	0.3	-1.4	0.0
Asthma	0.4	0.9	1.3	0.2	-1.2	-0.9	-1.1
Arm fat-free mass (right)	0.4	2.2	4.1	-1.1	0.1	-2.0	1.9
Comparative body size at age 10	0.4	1.0	2.3	0.2	0.4	-1.5	-1.2
Neck or shoulder pain in last month	0.4	0.5	1.3	-0.7	-0.2	1.1	0.6
Heart disease (mother)	0.4	0.5	1.3	-0.3	-0.0	0.6	-1.2
Arm predicted mass (right)	0.4	2.2	4.9	-0.9	0.1	-2.2	1.8
Had major operations	0.4	0.5	1.8	-0.1	0.6	1.3	0.1
Family relationship satisfaction	0.4	0.5	0.8	-0.4	0.4	0.9	0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.5	-1.2	-0.1	-0.1	-0.7
Diabetes diagnosed by doctor	0.4	0.6	2.1	-1.5	-0.0	0.6	-0.3
Eye problems/disorders: Cataract	0.4	0.5	1.6	-0.2	-0.3	1.3	-0.2
Asthma (self-reported)	0.4	0.8	1.4	-0.0	-1.2	-0.9	-1.1
Arm fat mass (left)	0.4	1.7	2.1	-1.1	-1.4	-1.4	-1.2
Arm fat-free mass (left)	0.4	2.2	3.5	-1.8	-0.5	-1.9	1.4
Fractured/broken bones in last 5 years	0.4	0.6	1.4	0.2	0.7	-0.6	-1.2
Unable to work because of sickness or disability	0.4	0.5	0.8	-0.9	0.3	0.7	-0.8
Commuting to job workplace: Cycle	0.4	0.4	1.3	-1.1	0.2	-0.5	-0.5
Supplements: Calcium	0.4	0.4	1.3	1.2	0.4	-0.4	-0.0
Leg fat mass (left)	0.4	1.5	3.2	-0.8	-0.8	-1.8	-1.3
Arm predicted mass (left)	0.4	1.9	2.9	-1.6	-0.5	-1.7	1.3
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	0.8	0.9	-0.1	-0.4
Irritable Bowel Disease (IBD)	0.3	0.7	2.4	-1.6	0.1	0.2	-0.7
Prostate Cancer	0.3	0.4	1.4	0.1	-0.1	0.4	-1.2
LDL Cholesterol	0.3	0.6	1.3	-0.0	0.9	-1.1	0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	0.3	-0.1	-1.0	-0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.9	-0.5	0.3	0.2	-1.4
Hearing difficulty/problems: Yes	0.3	0.5	1.1	0.0	-1.0	0.2	0.9
Supplements: Zinc	0.3	0.4	0.9	0.6	-0.4	-1.0	-0.0
Impedance of leg (right)	0.3	1.6	3.4	1.3	-0.1	1.2	-1.8
Leg fat-free mass (left)	0.3	1.4	3.0	-1.0	-1.0	-1.7	0.8
Average weekly fortified wine intake	0.3	0.3	0.6	-0.3	0.2	0.8	0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.9	0.9	0.9	1.0	0.2
Hearing difficulty/problems with background noise	0.3	0.5	0.9	0.2	1.0	0.8	0.8
Weight	0.3	1.5	2.4	-1.2	-1.4	-1.5	-0.3
Medication: Cholesterol lowering	0.3	0.5	1.0	-0.2	-0.7	0.7	-1.0
Pulse wave reflection index	0.3	0.4	0.8	0.6	-0.5	-0.9	0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.0	-0.5	-0.3	-1.0	0.1
Medication: Amlodipine	0.3	0.4	1.1	0.5	1.1	0.0	-0.3
Wheeze or whistling in the chest in last year	0.3	0.6	1.1	-1.0	-0.4	1.0	0.4
Shortness of breath walking on level ground	0.3	0.4	0.7	0.2	0.6	0.6	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	0.7	-0.5	0.1	-0.9
Medication: Allopurinol	0.3	0.5	0.7	0.8	0.1	-0.8	0.7
Alcohol intake frequency.	0.3	0.7	2.2	-0.7	0.5	0.1	1.5
Overall health rating	0.3	0.7	1.8	-1.3	-0.4	-0.1	-0.9
Whole body fat-free mass	0.3	1.5	2.6	-1.1	-0.5	-1.6	1.4
Average weekly red wine intake	0.3	0.4	1.2	0.2	-0.4	0.3	-1.1
Whole body water mass	0.3	1.5	2.8	-1.1	-0.5	-1.7	1.3
High cholesterol (Self-reported)	0.3	0.6	1.6	-0.7	-1.3	-0.4	0.4
Basal metabolic rate	0.3	1.4	3.0	-1.1	-0.8	-1.7	0.9
Irritability	0.3	0.5	1.0	0.8	-0.2	1.0	0.3
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	0.5	-0.2	-0.3	1.1
Pack years of smoking	0.3	0.4	1.3	0.6	0.3	-1.1	-0.1
Respiratory disease	0.2	0.4	0.5	-0.3	-0.6	-0.7	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.6	0.8	0.3	0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.8	-0.7	0.0	-0.9	0.8
High blood pressure	0.2	0.6	1.8	-0.5	-0.3	-1.3	-0.4
Leg predicted mass (left)	0.2	1.3	2.9	-0.9	-0.9	-1.7	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.3	1.2	0.1	0.3	-1.1	0.3
Allergy	0.2	0.6	0.8	-0.8	-0.6	-0.6	0.9
Neuroticism score	0.2	0.5	1.2	-0.2	-0.1	0.8	1.1
Trunk fat-free mass	0.2	1.3	2.2	-1.0	-0.3	-1.4	1.5
Number of live births	0.2	0.2	0.3	-0.5	0.3	0.6	0.5
Trunk predicted mass	0.2	1.2	2.3	-1.0	-0.2	-1.3	1.5
Length of working week for main job	0.2	0.2	0.7	-0.2	0.8	-0.4	-0.2
Glaucoma (self-reported)	0.2	0.3	1.1	0.1	-1.0	-0.1	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.1	-0.7	-0.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	0.6	-0.1	-0.2	-0.8
Age at first live birth	0.2	0.4	1.1	1.1	-0.0	0.1	0.7
Medication: Blood pressure	0.2	0.3	0.9	-0.6	-0.1	-1.0	-0.3
Comparative height size at age 10	0.2	1.0	2.1	1.4	0.1	1.0	-0.9
Hypertension (Self-reported)	0.2	0.4	1.1	-0.5	-0.4	-1.0	-0.4
Illnesses of father: Heart disease	0.2	0.2	0.3	0.5	0.3	-0.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.4	-0.3	-1.2	0.4	0.1
Leg fat-free mass (right)	0.2	0.9	2.3	-0.6	-0.4	-1.5	0.8
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	0.0	0.5	-0.6	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	-0.3	-1.0	-0.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.6	-0.5	-0.3	-0.4
Osteoporosis (self-reported)	0.2	0.2	0.8	0.9	0.2	-0.2	0.3
Leg predicted mass (right)	0.2	0.9	2.3	-0.6	-0.4	-1.5	0.9
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.3	0.4	0.5	-0.5	0.6
Medication: Lisinopril	0.2	0.3	0.8	0.1	-0.9	-0.5	-0.3
Neuroticism (2016)	0.1	0.1	0.3	0.4	0.0	0.1	-0.6
Heel T-Score	0.1	0.5	1.5	-0.6	-0.4	-0.2	-1.2
Allergy or Eczema	0.1	0.3	0.7	0.6	0.4	0.8	0.3
Hair Pigment	0.1	2.8	6.4	-2.0	-2.5	-0.7	0.1
Tanning	0.1	1.0	1.8	-1.4	0.7	0.7	1.2
Diabetes (father)	0.1	0.1	0.4	0.0	0.2	-0.3	-0.6
Sitting height	0.1	0.5	1.3	0.6	-1.2	-0.0	0.6
Nervous feelings	0.1	0.2	0.8	-0.2	-0.3	0.2	0.9
Standing height	0.1	0.8	1.9	1.4	-0.9	0.6	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	0.3	0.3	0.1	0.8
High blood pressure (siblings)	0.1	0.2	0.5	-0.3	-0.5	-0.7	-0.1
Number of full brothers	0.1	0.1	0.1	0.3	-0.0	0.2	0.3
Worry too long after embarrassment	0.1	0.1	0.2	0.2	-0.5	-0.1	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	-0.1	0.8	0.2	0.2
Medication: Aspirin	0.1	0.2	0.4	0.4	-0.2	-0.2	-0.6
Supplements: Vitamin C	0.1	0.1	0.4	0.0	0.3	0.1	-0.7
Medication for cholesterol	0.1	0.2	0.3	0.5	-0.4	0.6	0.1
Medication: Aspirin	0.1	0.1	0.2	0.1	-0.4	-0.2	-0.4
Medication: Gliclazide	0.1	0.2	0.3	-0.2	0.3	0.4	-0.6
Medication: Blood pressure	0.1	0.2	0.4	-0.7	0.4	-0.0	-0.6
Risk taking	0.1	0.1	0.3	0.3	0.0	0.6	-0.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	0.5	0.1	0.7	0.8
Cholesterol lowering medication	0.1	0.1	0.2	-0.2	-0.4	-0.4	0.4
Alzheimer’s Disease (including proxy)	0.0	0.1	0.2	0.1	0.4	0.0	-0.0
Height	0.0	0.7	1.7	0.6	-1.3	0.2	-0.7
Medication: Metformin	0.0	0.0	0.0	-0.2	-0.0	-0.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.1	-0.0	-0.4	-0.2

Hub : Genes

PDE7A

Models

Trait associations