Hub : Genes

PDZRN4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.329 0.0460 0.00000 0.320 0.261 0.347 0.338 0.341 7.1e-40 1.1e-31 8.5e-44 1.7e-42 6.9e-43
2 TCGA Glioblastoma Multiforme 0.139 0.0670 0.00720 0.047 0.049 0.036 NA 0.028 1.5e-02 1.3e-02 3.0e-02 NA 5.0e-02
3 TCGA Prostate Adenocarcinoma 0.103 0.0492 0.00028 0.043 0.034 0.046 NA 0.058 2.4e-05 1.7e-04 1.4e-05 NA 1.2e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.0 1.5 4.0 2.0 -0.5 0.5
Bipolar Disorder or Schizophrenia 0.2 0.5 0.8 -0.3 0.9 -0.8
Depressed Affect (Nagel 2018) 0.9 1.8 4.8 2.2 -0.3 0.8
Depression (Nagel 2018) 1.3 2.0 5.9 2.4 -0.0 0.1
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.4 -0.4 0.1 0.6
Neuroticism (Nagel 2018) 1.3 3.0 3.5 1.5 -1.8 1.9
Schizophrenia (2018) 1.4 2.9 4.0 -2.0 1.6 -1.5
Schizophrenia vs Biploar Disorder 2.7 3.5 8.7 -3.0 1.3 -0.3
Worry (Nagel 2018) 1.5 3.1 4.0 1.4 -1.8 2.0
Alzheimer’s Disease (in mother) 0.8 1.0 2.8 -0.2 0.1 -1.7
Alzheimer’s Disease (in father) 0.2 0.2 0.3 -0.5 0.1 0.5
Alzheimer’s Disease (including proxy) 0.5 0.7 1.7 -0.5 0.5 -1.3
Crohns Disease (2017) 0.3 0.6 1.1 0.5 -1.1 0.7
Irritable Bowel Disease (IBD) 0.2 0.5 0.9 -0.9 -0.6 0.6
Ulcerative Colitis (UC) 1.1 2.1 5.7 -2.4 0.7 -0.4
Major Depression (MDD) 1.7 2.1 5.2 -1.0 -0.4 2.3
Reaction Time 0.8 1.5 4.4 2.1 -0.4 0.2
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.5 -0.7 -0.2 0.4
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.6 2.1 3.4 1.2 -1.8 1.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 3.0 4.4 4.7 2.0 -2.1 2.2
Bipolar Disorder (2011) 1.8 1.7 4.4 2.1 -0.9 0.2
Body Mass Index (BMI) (2010) 7.1 9.7 13.0 3.4 -3.6 2.1
Coronary Artery Disease (CAD) 0.7 0.8 1.3 1.1 -0.9 -0.7
Crohns Disease (2012) 0.4 0.7 1.3 0.0 -0.9 1.1
Mean Putamen Volume 0.9 1.0 1.8 -0.8 1.3 -0.8
Fasting Glucose 0.1 0.1 0.2 0.1 0.4 -0.4
HbA1C 1.2 1.3 2.0 -0.7 1.4 -1.1
HDL Cholesterol 0.1 0.2 0.4 0.1 0.6 -0.3
LDL Cholesterol 0.2 0.3 0.4 -0.6 0.5 -0.5
Lupus 1.0 1.5 2.7 1.1 0.7 -1.6
Neuroticism (2016) 1.1 1.7 2.7 0.5 -1.6 1.4
Primary Biliary Cirrhosis 0.2 0.3 0.5 0.3 0.7 -0.6
Rheumatoid Arthritis 0.5 0.7 1.7 -0.4 1.3 -0.3
Schizophrenia (2014) 0.6 1.4 1.7 -1.2 1.0 -1.3
Triglycerides 0.1 0.1 0.2 0.3 0.4 0.4
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 0.2 -0.3 -0.5
Ulcerative Colitis 0.8 1.1 3.1 -1.8 -0.4 0.4
Blood Eosinophil Count 0.2 1.9 4.5 -2.1 1.1 0.0
Blood Platelet Count 0.4 4.4 9.2 -1.5 1.3 -3.0
Blood Red Count 0.0 0.2 0.4 -0.1 -0.5 0.6
Blood White Count 0.2 1.5 2.6 -0.5 1.6 -1.3
Heel T-Score 0.1 1.2 2.1 0.7 1.4 -1.0
BMI 3.9 22.9 33.6 5.8 -5.7 1.6
Height 0.2 4.1 9.3 3.0 -1.2 1.2
Waist Hip Ratio (WHR) 1.2 5.3 11.0 3.3 -2.2 -0.4
Systolic Blood Pressure 0.3 1.6 3.1 -1.8 -0.8 1.1
Smoking Status 1.3 3.2 5.3 2.3 -1.7 1.2
Allergy or Eczema 0.5 1.3 1.7 1.0 -1.3 1.0
Cardiovascular Disease 2.2 7.4 15.7 1.9 -4.0 1.6
Hypothyroidism (self reported) 1.0 2.4 5.2 -1.3 2.3 -0.5
Respiratory disease 0.9 2.0 4.7 -0.2 1.1 -2.2
Type 2 Diabetes (T2D) (2018) 0.9 1.6 3.0 1.7 -1.4 -0.0
Lung FEV1/FVC ratio 1.9 9.4 14.4 0.5 -3.8 3.7
Lung FVC 0.5 2.6 7.6 0.6 2.8 -0.1
Neuroticism 1.8 4.3 9.2 3.0 -1.7 0.9
Chronotype (morning person) 0.5 1.2 2.3 -0.6 1.5 -1.0
Hair Pigment 0.0 0.3 0.5 -0.4 0.7 -0.3
Tanning 0.0 0.5 1.1 0.2 -0.5 -1.1
Hand grip strength (left) 0.3 0.7 1.0 0.6 0.9 1.0
Number of treatments/medications taken 0.6 1.0 2.2 0.9 -0.1 -1.5
Average weekly spirits intake 0.5 0.6 1.3 0.6 0.4 -1.2
Sensitivity / hurt feelings 2.2 3.8 8.6 2.9 -1.1 1.3
Frequency of depressed mood in last 2 weeks 0.8 1.1 3.1 1.8 -0.5 -0.3
Hearing difficulty/problems: Yes 0.7 1.1 1.6 1.3 -0.1 -1.2
Relative age of first facial hair 0.1 0.3 0.6 -0.5 0.0 -0.8
Other serious medical condition/disability diagnosed by doctor 5.9 7.6 15.4 0.5 2.7 -3.9
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.9 0.3 -0.1 -1.4
Ever had hysterectomy (womb removed) 0.9 1.0 2.9 -1.7 -0.3 0.2
Systolic blood pressure, automated reading 0.5 1.4 2.3 -0.8 -1.5 1.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.5 -1.0 0.4 1.2
Angina 0.3 0.4 1.0 0.4 -1.0 0.2
Medication for hormone replacement therapy 0.2 0.2 0.6 0.0 -0.8 -0.2
Vitamin and mineral supplements 1.2 1.6 4.6 -2.1 0.2 0.3
Supplements: Zinc 1.3 1.4 2.4 1.5 -1.4 -0.4
Medication: Co-codamol 1.6 1.9 2.4 1.6 -1.0 1.5
Medication: Metformin 0.3 0.4 0.8 0.9 -0.6 0.2
Diabetes (father) 5.9 7.4 13.0 3.6 -2.7 1.3
Diabetes (mother) 0.5 0.7 1.9 0.3 0.1 1.4
Severe depression (siblings) 0.9 1.0 2.1 1.5 0.3 0.9
Pack years adult smoking proportion 1.5 2.3 3.6 -1.7 1.9 -0.4
Impedance of leg (right) 0.6 3.0 4.9 -2.2 2.0 -0.4
Leg fat-free mass (left) 1.7 8.9 15.4 3.9 -3.1 1.3
Trunk fat percentage 1.7 6.7 9.8 2.7 -3.1 1.8
Hand grip strength (right) 0.5 1.3 3.0 0.9 -0.3 1.7
Townsend deprivation index at recruitment 0.5 0.7 1.6 -1.3 0.7 -0.0
Current tobacco smoking 0.4 0.6 1.4 0.0 0.6 -1.2
Average weekly fortified wine intake 2.4 2.8 5.6 1.4 -2.4 0.9
Maternal smoking around birth 2.2 3.1 5.4 -1.7 2.3 -1.1
Fed-up feelings 0.5 1.0 2.3 1.5 0.3 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 4.1 2.0 0.2 -0.5
Relative age voice broke 0.4 0.7 1.3 -0.2 -0.8 -1.2
Taking other prescription medications 0.5 0.8 1.2 1.1 0.7 -0.8
Age when periods started (menarche) 1.3 3.2 5.7 -1.5 2.4 -1.3
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.2 0.3 -1.1 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 2.6 1.2 0.6 -1.6
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 3.8 0.1 1.9 -1.1
Qualifications: CSEs or equivalent 0.2 0.3 0.8 -0.9 -0.3 0.2
Serious illness, injury or assault to yourself 0.5 0.6 1.0 1.0 -0.7 -0.5
High blood pressure 1.8 5.1 9.7 1.0 -3.1 2.2
Hayfever, allergic rhinitis or eczema 0.5 1.1 1.4 1.1 -0.8 1.2
Multivitamins +/- minerals 2.3 3.0 8.2 2.9 -0.9 0.0
Stomach or abdominal pain in last month 0.0 0.0 0.0 0.1 -0.1 -0.2
Supplements: Glucosamine 3.1 4.0 10.0 1.2 -3.2 0.8
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.1 0.4 -0.5 1.1
Medication: Atenolol 1.2 1.5 2.2 1.2 -1.5 0.9
Medication: Levothyroxine sodium 1.6 2.7 5.4 -0.6 2.3 -1.6
Sitting height 0.2 1.2 1.5 1.1 1.2 -1.0
Chronic bronchitis/emphysema (father) 1.2 1.4 2.8 -0.7 1.7 -0.9
High blood pressure (mother) 5.5 7.7 11.9 1.3 -3.5 3.1
Body mass index (BMI) 2.6 10.9 18.4 4.3 -3.7 1.1
Impedance of leg (left) 0.5 2.3 4.0 -2.0 1.7 0.2
Leg predicted mass (left) 1.7 8.8 15.7 4.0 -3.1 1.2
Trunk fat mass 2.8 12.0 16.2 4.0 -4.0 2.0
Waist circumference 5.6 20.6 38.2 6.2 -4.8 0.9
Number of incorrect matches in round 0.0 0.1 0.2 0.4 0.2 -0.0
Past tobacco smoking 3.8 7.0 12.8 -3.6 2.0 -2.1
Alcohol usually taken with meals 5.7 9.2 15.6 4.0 -2.9 1.9
Nervous feelings 1.4 2.7 5.5 1.4 -2.3 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.9 1.0 -0.2 -0.0
Hearing difficulty/problems with background noise 1.3 2.1 6.2 2.5 0.1 -0.3
Hair/balding pattern: Pattern 2 0.6 0.8 1.7 1.3 -0.8 0.3
Had menopause 0.3 0.3 0.5 -0.7 -0.7 0.0
Had other major operations 0.6 0.7 1.7 0.7 1.3 -0.2
Forced vital capacity (FVC) 0.3 1.3 1.9 0.7 1.4 1.2
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.2 3.3 0.6 1.7 -1.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.2 0.7 0.3 1.1
Qualifications: None of the above 2.4 5.2 6.0 -2.2 2.5 -2.1
Financial difficulties in last 2 years 0.3 0.5 0.7 0.9 0.0 0.8
Mouth/teeth dental problems 0.3 0.5 0.7 -0.8 -0.4 0.7
Heart attack 0.2 0.3 0.5 0.7 -0.3 -0.4
Allergy 0.6 1.4 2.4 -1.4 1.6 -0.3
Pain all over the body in last month 0.5 0.5 1.2 0.4 1.1 -0.4
Diabetes (self-reported) 1.0 1.5 3.1 1.8 -1.0 0.6
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 2.7 1.7 -0.8 1.0
Medication: Ramipril 0.3 0.3 0.6 0.2 -0.8 0.6
Medication: Simvastatin 0.3 0.4 1.1 1.0 0.1 -0.3
Fluid intelligence score 0.3 0.6 1.2 0.3 -1.1 0.8
Illnesses of siblings 1.2 1.7 3.8 -0.6 0.9 -1.9
Neuroticism score 1.1 2.3 4.4 2.1 -1.2 1.0
Weight 3.2 15.9 26.8 5.2 -4.2 1.8
Impedance of arm (right) 1.2 5.5 13.3 -3.6 1.7 0.5
Arm fat percentage (right) 2.0 8.0 12.8 3.1 -3.6 1.3
Trunk fat-free mass 1.9 11.0 23.7 4.9 -3.0 0.6
Hip circumference 2.1 9.2 17.9 4.2 -3.1 0.6
Time employed in main current job 0.5 0.5 0.9 0.5 -0.9 0.7
Alcohol intake versus 10 years previously 1.0 1.6 2.2 -1.0 1.5 -1.3
Father’s age at death 0.3 0.4 1.0 0.4 -1.0 -0.2
Worrier / anxious feelings 4.7 8.8 11.4 2.3 -3.4 3.1
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 2.2 0.8 1.5 -1.0
Falls in the last year 1.2 1.7 3.9 1.1 -2.0 0.0
Hair/balding pattern: Pattern 3 0.4 0.5 1.5 -1.2 -0.3 -0.1
Number of live births 0.9 1.2 1.4 -1.2 1.1 -1.1
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 5.9 0.8 0.5 2.4
Pulse rate 0.4 0.7 1.4 0.4 -1.2 -0.8
Happiness 0.5 0.7 1.3 1.2 -0.3 0.7
Noisy workplace 1.3 1.7 2.8 -0.3 1.7 -1.5
Qualifications: A levels/AS levels or equivalent 2.0 4.3 6.5 2.0 -1.6 2.5
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.4 1.6 -0.7 -0.1
Mouth/teeth dental problems: Dentures 0.6 1.0 1.6 -0.1 -1.3 1.2
Asthma 0.2 0.3 0.6 0.3 -0.6 -0.8
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 3.4 0.3 0.9 -1.9
Medication: Cholesterol lowering 0.2 0.3 0.3 -0.4 0.6 -0.6
Depression (self-reported) 0.7 0.8 2.0 0.7 -1.4 0.0
Medication: Lansoprazole 0.2 0.2 0.4 0.4 0.4 0.6
Prospective memory result 0.1 0.1 0.2 -0.3 -0.2 -0.4
Lung cancer (father) 0.3 0.3 0.8 0.0 0.9 0.5
Illnesses of mother 2.0 2.4 4.5 -1.0 2.1 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.7 7.0 1.0 -0.4 2.7
Pulse wave Arterial Stiffness index 0.5 0.6 1.4 -0.6 0.3 -1.2
Impedance of arm (left) 1.8 8.4 19.7 -4.4 2.3 0.3
Arm fat mass (right) 2.6 10.9 16.7 4.1 -3.7 1.4
Trunk predicted mass 2.0 11.3 24.0 4.9 -3.1 0.7
Standing height 0.3 2.8 5.0 2.2 -1.2 1.4
Length of working week for main job 0.3 0.4 0.5 0.6 -0.3 0.7
Exposure to tobacco smoke at home 1.4 1.5 2.7 0.7 -1.2 1.6
Breastfed as a baby 0.4 0.5 1.2 0.4 0.3 -1.1
Tense / ‘highly strung’ 0.4 0.6 1.0 -0.5 0.7 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 1.9 4.8 2.2 -0.3 -0.9
Hair/balding pattern: Pattern 4 0.2 0.6 1.4 0.3 1.2 0.6
Birth weight of first child 0.1 0.2 0.5 0.4 0.3 -0.7
Peak expiratory flow (PEF) 0.7 1.6 2.4 0.6 1.6 1.5
Pulse wave reflection index 0.8 1.0 2.6 0.4 0.3 -1.6
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.1 1.0 -0.7 0.3
Loud music exposure frequency 0.1 0.1 0.2 -0.5 0.2 0.1
Qualifications: O levels/GCSEs or equivalent 2.7 4.4 5.4 2.2 -2.3 1.7
Mouth/teeth dental problems: Bleeding gums 2.0 2.6 5.6 2.4 -0.1 -1.5
Blood clot in the leg (DVT) 0.6 0.8 1.2 1.0 -1.1 0.3
Medication: Paracetamol 1.1 1.7 4.3 2.1 -0.9 -0.4
Headache pain in last month 0.1 0.2 0.4 -0.3 0.3 -0.7
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 1.8 0.1 1.3 -1.0
Glaucoma (self-reported) 0.8 1.0 2.2 1.5 -0.5 -0.7
Gout (self-reported) 0.6 0.8 1.0 1.0 0.7 -0.8
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 3.4 -1.1 1.9 -1.0
Medication: Amlodipine 0.8 1.2 2.7 -1.6 0.2 0.8
Medication: Ventolin 100micrograms inhaler 1.3 1.7 3.3 0.7 -1.1 -1.8
Birth weight 0.8 1.7 2.0 1.4 -1.4 -1.1
Chronic bronchitis/emphysema (mother) 1.0 1.1 2.3 -1.1 1.5 -0.0
High blood pressure (siblings) 1.7 2.5 4.4 0.8 -2.1 1.5
Forced vital capacity (FVC), Best measure 0.5 1.9 4.1 1.3 0.2 2.0
Body fat percentage 2.4 9.5 13.1 3.5 -3.6 1.8
Leg fat percentage (right) 3.3 12.1 18.4 4.3 -3.9 1.7
Arm fat-free mass (right) 2.0 10.3 22.0 4.7 -2.8 0.9
Exposure to tobacco smoke outside home 0.7 0.9 1.6 -0.3 -1.1 1.2
Comparative body size at age 10 0.0 0.1 0.3 0.2 -0.0 -0.5
Number of full brothers 1.7 2.1 5.2 1.1 -0.0 2.3
Worry too long after embarrassment 1.8 3.0 4.6 0.2 -2.2 2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.0 1.0 0.0 -0.2
Wheeze or whistling in the chest in last year 0.5 0.9 2.3 0.6 -0.1 -1.5
Number of children fathered 0.5 0.6 1.0 1.0 0.8 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.3 0.7 -1.1 0.4
Age at first live birth 1.2 2.1 4.5 2.1 -1.4 -0.4
Pulse wave peak to peak time 0.5 0.6 1.5 0.5 -0.3 1.2
Health satisfaction 0.4 0.5 1.3 1.1 0.4 -0.4
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.3 0.2 -0.4
Qualifications: College or University degree 1.2 3.7 4.6 2.1 -2.1 1.4
Eye problems/disorders: None of the above 0.5 0.6 0.9 -0.9 1.0 -0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.7 0.4 0.8 0.6
Emphysema/chronic bronchitis 1.5 1.7 3.8 0.4 1.0 -1.9
Medication for pain relief, constipation, heartburn 0.9 1.6 2.7 -1.7 1.4 0.4
Neck or shoulder pain in last month 0.4 0.6 1.1 1.1 -0.6 -0.6
Medication: Blood pressure 2.1 3.7 6.7 0.2 -2.6 2.1
Angina (self-reported) 0.4 0.5 1.3 0.4 -1.1 0.3
Migraine (self-reported) 0.3 0.4 0.7 0.8 0.6 -0.2
Medication: Ibuprofen 0.6 0.7 1.8 -0.3 0.5 -1.3
Medication: Allopurinol 1.9 2.5 6.4 -0.5 0.9 -2.5
Medication: Omeprazole 1.9 2.3 3.3 1.7 -1.8 0.8
Medication: Seretide 50 evohaler 2.3 2.7 7.5 -0.5 0.5 -2.7
Mean time to correctly identify matches 0.5 1.0 2.7 1.6 -0.5 0.3
Heart disease (mother) 3.4 4.1 9.2 1.6 -3.0 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.1 -0.2 -0.3 0.3
Whole body fat mass 3.2 13.2 20.2 4.5 -4.0 1.9
Leg fat mass (right) 4.2 16.4 25.7 5.1 -4.5 1.9
Arm predicted mass (right) 1.8 9.4 20.5 4.5 -2.7 0.6
Pulse rate, automated reading 0.0 0.1 0.2 0.5 -0.1 0.2
Alcohol intake frequency. 1.5 3.6 6.8 -2.6 1.6 -1.2
Comparative height size at age 10 0.1 0.6 1.1 0.9 0.3 1.1
Number of full sisters 2.7 3.2 6.5 -2.5 1.7 0.7
Suffer from ‘nerves’ 0.6 0.9 1.9 0.7 -1.4 0.7
Overall health rating 0.3 0.6 0.7 0.7 0.8 -0.8
Chest pain or discomfort 2.2 3.1 8.0 0.5 1.1 -2.8
Had major operations 0.5 0.5 1.3 1.1 -0.1 -0.6
Age at last live birth 0.5 0.7 1.4 1.2 -0.3 -0.9
Family relationship satisfaction 1.0 1.3 2.2 -0.7 1.5 -1.1
Leg pain on walking 0.3 0.4 0.6 -0.7 -0.2 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 0.9 0.8 0.9 -0.9
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.3 1.1 -0.5 -0.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 -0.1 0.4 -0.3
Medication: Aspirin 0.3 0.3 0.8 -0.4 -0.9 0.1
Supplements: Vitamin C 0.6 0.7 1.3 1.1 -0.6 0.7
Knee pain experienced in last month 0.0 0.0 0.0 0.0 -0.2 0.0
Hypertension (Self-reported) 2.0 5.5 11.4 1.1 -3.4 2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.2 3.7 4.2 1.8 -1.9 2.0
Illnesses of father: Heart disease 0.1 0.2 0.4 -0.1 -0.7 0.3
Illnesses of siblings: Diabetes 1.2 1.4 3.0 0.6 -0.9 1.7
Smoking status: Previous 3.2 4.8 7.5 2.7 -1.5 2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.1 0.2 -0.0 0.4
Whole body fat-free mass 1.9 11.0 22.2 4.7 -3.2 0.9
Leg fat-free mass (right) 1.6 8.8 15.7 4.0 -3.0 1.4
Arm fat percentage (left) 2.0 7.9 13.2 3.0 -3.6 1.3
Average weekly red wine intake 1.3 1.9 4.3 2.1 -1.2 -0.0
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.5 -0.0 -0.6 0.7
Mood swings 0.4 0.8 2.2 1.5 -0.2 0.3
Loneliness, isolation 0.3 0.4 0.5 0.3 0.7 -0.7
Long-standing illness, disability or infirmity 1.7 2.7 4.7 0.5 1.8 -2.2
Ever had bowel cancer screening 0.9 1.1 1.8 1.1 -1.3 0.6
Diabetes diagnosed by doctor 0.9 1.4 3.1 1.8 -1.0 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.2 -0.7 0.7 1.1
Friendships satisfaction 0.2 0.2 0.4 -0.7 -0.1 0.5
Qualifications: nursing, teaching 5.3 8.3 14.9 1.0 -3.9 3.0
Commuting to job workplace: Walk 0.9 1.0 3.0 0.2 -0.3 1.7
Eye problems/disorders: Cataract 1.0 1.2 2.0 1.1 -1.4 0.6
Mouth/teeth dental problems: Mouth ulcers 0.7 1.0 2.8 1.7 0.6 -0.2
Medication for cholesterol 0.9 1.4 2.2 -1.5 1.1 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.7 4.3 0.8 -2.1 0.6
Back pain experienced in last month 3.9 5.7 9.7 -0.3 3.1 -2.7
Mineral and other dietary supplements 1.4 1.9 3.3 -1.3 1.8 -0.8
Breast cancer (self-reported) 0.0 0.0 0.1 0.0 -0.4 0.1
Asthma (self-reported) 0.1 0.3 0.5 0.3 -0.5 -0.7
Osteoporosis (self-reported) 0.8 1.0 2.0 0.8 -0.6 1.4
Osteoarthritis (self-reported) 0.8 1.1 2.1 -0.9 1.5 -0.5
Medication: Aspirin 0.3 0.4 0.9 -0.5 -1.0 0.3
Medication: Gliclazide 0.9 1.0 2.8 -0.4 -0.3 1.7
Illnesses of father: None of the above (group 1) 1.3 1.6 2.2 -0.8 1.5 -1.4
Smoking status: Current 0.2 0.3 0.7 0.5 -0.3 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 5.3 0.1 -0.5 2.3
Whole body water mass 1.9 10.6 21.6 4.6 -3.1 0.8
Leg predicted mass (right) 1.6 8.6 15.2 3.9 -2.9 1.4
Arm fat mass (left) 2.8 11.7 18.5 4.3 -3.9 1.2
Number of self-reported non-cancer illnesses 0.6 1.0 2.5 1.6 -0.5 -0.7
Average weekly champagne plus white wine intake 0.2 0.2 0.5 0.7 0.1 0.5
Miserableness 1.1 1.8 4.9 2.2 0.0 -0.8
Guilty feelings 0.5 0.7 1.6 1.3 -0.7 0.0
Wears glasses or contact lenses 5.3 6.1 10.5 2.2 -3.2 1.6
Ever taken oral contraceptive pill 1.1 1.2 3.5 -0.1 1.9 0.2
Hearing aid user 1.1 1.2 2.0 1.4 -0.3 1.3
Mother’s age at death 0.6 0.7 1.6 0.6 -0.3 -1.3
Financial situation satisfaction 0.6 0.8 1.9 -0.6 1.4 -0.1
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.9 0.6 1.4 -0.7
Commuting to job workplace: Public transport 0.4 0.4 1.0 0.4 0.4 1.0
Eye problems/disorders: Glaucoma 0.6 0.7 1.7 1.3 -0.5 -0.0
Medication: Blood pressure 0.6 1.1 2.4 1.5 -1.0 0.0
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.3 0.6 1.1 -0.6
Supplements: Fish oil (including cod liver oil) 1.6 2.1 3.4 1.7 -1.9 -0.1
High cholesterol (Self-reported) 1.6 2.8 6.5 -0.9 1.0 -2.5
Medication: Bendroflumethiazide 0.1 0.1 0.3 0.2 -0.5 -0.1
Medication: Paracetamol 1.0 1.5 2.8 1.7 -1.3 -0.4
Medication: Lisinopril 0.2 0.2 0.4 0.6 -0.4 -0.2
Medication: Atorvastatin 1.3 1.6 3.4 -0.6 1.1 -1.8
Illnesses of father: High blood pressure 5.6 6.9 13.0 0.6 -2.7 3.6
Alcohol drinker status: Never 0.2 0.3 0.6 0.4 0.0 -0.8
Ever smoked 4.7 8.2 18.8 4.3 -1.9 1.4
Basal metabolic rate 2.2 11.9 23.5 4.8 -3.3 1.1
Leg fat percentage (left) 4.0 14.6 22.0 4.7 -4.1 2.2
Arm fat-free mass (left) 2.5 12.9 28.0 5.3 -3.1 1.1
Number of operations (self-reported) 2.2 3.3 5.0 -0.6 2.1 -2.2
Average weekly beer plus cider intake 0.9 1.4 2.3 -1.2 0.5 -1.5
Irritability 0.0 0.1 0.1 0.1 -0.2 0.4
Risk taking 1.6 2.3 3.9 0.7 1.6 -2.0
Ever had prostate specific antigen (PSA) test 7.2 8.3 19.4 4.4 -2.3 0.6
Fractured/broken bones in last 5 years 0.3 0.4 0.8 0.4 -0.3 0.9
Age started oral contraceptive pill 3.1 3.9 6.8 0.6 -2.6 2.1
Diastolic blood pressure, automated reading 0.3 0.9 1.3 -0.8 -1.1 0.9
Ever depressed for a whole week 0.7 0.8 1.1 0.8 1.1 -0.8
Unable to work because of sickness or disability 0.3 0.4 1.0 0.5 -0.1 -1.0
Commuting to job workplace: Cycle 0.7 0.8 1.4 1.2 -1.0 -0.2
Myopia 0.2 0.3 0.6 0.8 -0.4 0.1
Vascular/heart problems diagnosed by doctor 1.3 3.5 6.3 -1.1 2.5 -1.7
Cholesterol lowering medication 2.1 3.1 8.6 0.5 0.6 -2.9
Medication: Omeprazole (e.g. Zanprol) 2.5 3.1 4.6 1.9 -2.2 0.9
Pain experienced in last month 0.4 0.6 1.1 0.3 -1.1 0.7
Supplements: Calcium 1.1 1.2 3.5 -0.1 -0.4 1.9
Basal cell carcinoma (self-reported) 0.6 0.8 0.9 0.7 -0.9 0.9
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.8 0.9 -0.5 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.0 1.0 -1.0 0.3
Heart disease (siblings) 0.3 0.3 0.6 0.5 0.8 -0.5
Alcohol drinker status: Previous 0.5 0.6 1.5 -0.5 -0.3 1.2
Pack years of smoking 1.9 2.8 4.4 -2.1 2.0 -0.3
Impedance of whole body 1.4 7.0 14.0 -3.7 2.6 0.2
Leg fat mass (left) 4.8 18.8 28.3 5.3 -4.8 2.2
Arm predicted mass (left) 2.6 13.2 28.0 5.3 -3.3 0.8