TWAS hub - PDZRN4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.329	0.0460	0.00000	0.320	0.261	0.347	0.338	0.341	7.1e-40	1.1e-31	8.5e-44	1.7e-42	6.9e-43
2	TCGA	Glioblastoma Multiforme	0.139	0.0670	0.00720	0.047	0.049	0.036	NA	0.028	1.5e-02	1.3e-02	3.0e-02	NA	5.0e-02
3	TCGA	Prostate Adenocarcinoma	0.103	0.0492	0.00028	0.043	0.034	0.046	NA	0.058	2.4e-05	1.7e-04	1.4e-05	NA	1.2e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Ever had prostate specific antigen (PSA) test	7.2	8.3	19.4	4.4	-2.3	0.6
Body Mass Index (BMI) (2010)	7.1	9.7	13.0	3.4	-3.6	2.1
Other serious medical condition/disability diagnosed by doctor	5.9	7.6	15.4	0.5	2.7	-3.9
Diabetes (father)	5.9	7.4	13.0	3.6	-2.7	1.3
Alcohol usually taken with meals	5.7	9.2	15.6	4.0	-2.9	1.9
Waist circumference	5.6	20.6	38.2	6.2	-4.8	0.9
Illnesses of father: High blood pressure	5.6	6.9	13.0	0.6	-2.7	3.6
High blood pressure (mother)	5.5	7.7	11.9	1.3	-3.5	3.1
Qualifications: nursing, teaching	5.3	8.3	14.9	1.0	-3.9	3.0
Wears glasses or contact lenses	5.3	6.1	10.5	2.2	-3.2	1.6
Leg fat mass (left)	4.8	18.8	28.3	5.3	-4.8	2.2
Worrier / anxious feelings	4.7	8.8	11.4	2.3	-3.4	3.1
Ever smoked	4.7	8.2	18.8	4.3	-1.9	1.4
Leg fat mass (right)	4.2	16.4	25.7	5.1	-4.5	1.9
Leg fat percentage (left)	4.0	14.6	22.0	4.7	-4.1	2.2
BMI	3.9	22.9	33.6	5.8	-5.7	1.6
Back pain experienced in last month	3.9	5.7	9.7	-0.3	3.1	-2.7
Past tobacco smoking	3.8	7.0	12.8	-3.6	2.0	-2.1
Heart disease (mother)	3.4	4.1	9.2	1.6	-3.0	0.8
Leg fat percentage (right)	3.3	12.1	18.4	4.3	-3.9	1.7
Weight	3.2	15.9	26.8	5.2	-4.2	1.8
Whole body fat mass	3.2	13.2	20.2	4.5	-4.0	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.2	3.7	4.2	1.8	-1.9	2.0
Smoking status: Previous	3.2	4.8	7.5	2.7	-1.5	2.1
Supplements: Glucosamine	3.1	4.0	10.0	1.2	-3.2	0.8
Age started oral contraceptive pill	3.1	3.9	6.8	0.6	-2.6	2.1
Age at First Birth	3.0	4.4	4.7	2.0	-2.1	2.2
Trunk fat mass	2.8	12.0	16.2	4.0	-4.0	2.0
Arm fat mass (left)	2.8	11.7	18.5	4.3	-3.9	1.2
Schizophrenia vs Biploar Disorder	2.7	3.5	8.7	-3.0	1.3	-0.3
Qualifications: O levels/GCSEs or equivalent	2.7	4.4	5.4	2.2	-2.3	1.7
Number of full sisters	2.7	3.2	6.5	-2.5	1.7	0.7
Body mass index (BMI)	2.6	10.9	18.4	4.3	-3.7	1.1
Arm fat mass (right)	2.6	10.9	16.7	4.1	-3.7	1.4
Arm predicted mass (left)	2.6	13.2	28.0	5.3	-3.3	0.8
Arm fat-free mass (left)	2.5	12.9	28.0	5.3	-3.1	1.1
Medication: Omeprazole (e.g. Zanprol)	2.5	3.1	4.6	1.9	-2.2	0.9
Average weekly fortified wine intake	2.4	2.8	5.6	1.4	-2.4	0.9
Qualifications: None of the above	2.4	5.2	6.0	-2.2	2.5	-2.1
Body fat percentage	2.4	9.5	13.1	3.5	-3.6	1.8
Multivitamins +/- minerals	2.3	3.0	8.2	2.9	-0.9	0.0
Medication: Seretide 50 evohaler	2.3	2.7	7.5	-0.5	0.5	-2.7
Cardiovascular Disease	2.2	7.4	15.7	1.9	-4.0	1.6
Sensitivity / hurt feelings	2.2	3.8	8.6	2.9	-1.1	1.3
Maternal smoking around birth	2.2	3.1	5.4	-1.7	2.3	-1.1
Chest pain or discomfort	2.2	3.1	8.0	0.5	1.1	-2.8
Basal metabolic rate	2.2	11.9	23.5	4.8	-3.3	1.1
Number of operations (self-reported)	2.2	3.3	5.0	-0.6	2.1	-2.2
Hip circumference	2.1	9.2	17.9	4.2	-3.1	0.6
Medication: Blood pressure	2.1	3.7	6.7	0.2	-2.6	2.1
Cholesterol lowering medication	2.1	3.1	8.6	0.5	0.6	-2.9
Arm fat percentage (right)	2.0	8.0	12.8	3.1	-3.6	1.3
Qualifications: A levels/AS levels or equivalent	2.0	4.3	6.5	2.0	-1.6	2.5
Illnesses of mother	2.0	2.4	4.5	-1.0	2.1	-1.3
Trunk predicted mass	2.0	11.3	24.0	4.9	-3.1	0.7
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	5.6	2.4	-0.1	-1.5
Arm fat-free mass (right)	2.0	10.3	22.0	4.7	-2.8	0.9
Hypertension (Self-reported)	2.0	5.5	11.4	1.1	-3.4	2.0
Arm fat percentage (left)	2.0	7.9	13.2	3.0	-3.6	1.3
Lung FEV1/FVC ratio	1.9	9.4	14.4	0.5	-3.8	3.7
Trunk fat-free mass	1.9	11.0	23.7	4.9	-3.0	0.6
Medication: Allopurinol	1.9	2.5	6.4	-0.5	0.9	-2.5
Medication: Omeprazole	1.9	2.3	3.3	1.7	-1.8	0.8
Whole body fat-free mass	1.9	11.0	22.2	4.7	-3.2	0.9
Whole body water mass	1.9	10.6	21.6	4.6	-3.1	0.8
Pack years of smoking	1.9	2.8	4.4	-2.1	2.0	-0.3
Bipolar Disorder (2011)	1.8	1.7	4.4	2.1	-0.9	0.2
Neuroticism	1.8	4.3	9.2	3.0	-1.7	0.9
High blood pressure	1.8	5.1	9.7	1.0	-3.1	2.2
Impedance of arm (left)	1.8	8.4	19.7	-4.4	2.3	0.3
Worry too long after embarrassment	1.8	3.0	4.6	0.2	-2.2	2.1
Arm predicted mass (right)	1.8	9.4	20.5	4.5	-2.7	0.6
Major Depression (MDD)	1.7	2.1	5.2	-1.0	-0.4	2.3
Leg fat-free mass (left)	1.7	8.9	15.4	3.9	-3.1	1.3
Trunk fat percentage	1.7	6.7	9.8	2.7	-3.1	1.8
Leg predicted mass (left)	1.7	8.8	15.7	4.0	-3.1	1.2
High blood pressure (siblings)	1.7	2.5	4.4	0.8	-2.1	1.5
Number of full brothers	1.7	2.1	5.2	1.1	-0.0	2.3
Long-standing illness, disability or infirmity	1.7	2.7	4.7	0.5	1.8	-2.2
Ovarian Cancer	1.6	2.1	3.4	1.2	-1.8	1.2
Medication: Co-codamol	1.6	1.9	2.4	1.6	-1.0	1.5
Medication: Levothyroxine sodium	1.6	2.7	5.4	-0.6	2.3	-1.6
Leg fat-free mass (right)	1.6	8.8	15.7	4.0	-3.0	1.4
Leg predicted mass (right)	1.6	8.6	15.2	3.9	-2.9	1.4
Supplements: Fish oil (including cod liver oil)	1.6	2.1	3.4	1.7	-1.9	-0.1
High cholesterol (Self-reported)	1.6	2.8	6.5	-0.9	1.0	-2.5
Risk taking	1.6	2.3	3.9	0.7	1.6	-2.0
Worry (Nagel 2018)	1.5	3.1	4.0	1.4	-1.8	2.0
Pack years adult smoking proportion	1.5	2.3	3.6	-1.7	1.9	-0.4
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.8	0.1	1.9	-1.1
Emphysema/chronic bronchitis	1.5	1.7	3.8	0.4	1.0	-1.9
Alcohol intake frequency.	1.5	3.6	6.8	-2.6	1.6	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	4.3	0.8	-2.1	0.6
Schizophrenia (2018)	1.4	2.9	4.0	-2.0	1.6	-1.5
Nervous feelings	1.4	2.7	5.5	1.4	-2.3	0.7
Exposure to tobacco smoke at home	1.4	1.5	2.7	0.7	-1.2	1.6
Mineral and other dietary supplements	1.4	1.9	3.3	-1.3	1.8	-0.8
Impedance of whole body	1.4	7.0	14.0	-3.7	2.6	0.2
Depression (Nagel 2018)	1.3	2.0	5.9	2.4	-0.0	0.1
Neuroticism (Nagel 2018)	1.3	3.0	3.5	1.5	-1.8	1.9
Smoking Status	1.3	3.2	5.3	2.3	-1.7	1.2
Supplements: Zinc	1.3	1.4	2.4	1.5	-1.4	-0.4
Age when periods started (menarche)	1.3	3.2	5.7	-1.5	2.4	-1.3
Hearing difficulty/problems with background noise	1.3	2.1	6.2	2.5	0.1	-0.3
Noisy workplace	1.3	1.7	2.8	-0.3	1.7	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	4.8	2.2	-0.3	-0.9
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.3	0.7	-1.1	-1.8
Average weekly red wine intake	1.3	1.9	4.3	2.1	-1.2	-0.0
Illnesses of father: None of the above (group 1)	1.3	1.6	2.2	-0.8	1.5	-1.4
Medication: Atorvastatin	1.3	1.6	3.4	-0.6	1.1	-1.8
Vascular/heart problems diagnosed by doctor	1.3	3.5	6.3	-1.1	2.5	-1.7
HbA1C	1.2	1.3	2.0	-0.7	1.4	-1.1
Waist Hip Ratio (WHR)	1.2	5.3	11.0	3.3	-2.2	-0.4
Vitamin and mineral supplements	1.2	1.6	4.6	-2.1	0.2	0.3
Medication: Atenolol	1.2	1.5	2.2	1.2	-1.5	0.9
Chronic bronchitis/emphysema (father)	1.2	1.4	2.8	-0.7	1.7	-0.9
Illnesses of siblings	1.2	1.7	3.8	-0.6	0.9	-1.9
Impedance of arm (right)	1.2	5.5	13.3	-3.6	1.7	0.5
Falls in the last year	1.2	1.7	3.9	1.1	-2.0	0.0
Age at first live birth	1.2	2.1	4.5	2.1	-1.4	-0.4
Qualifications: College or University degree	1.2	3.7	4.6	2.1	-2.1	1.4
Illnesses of siblings: Diabetes	1.2	1.4	3.0	0.6	-0.9	1.7
Ulcerative Colitis (UC)	1.1	2.1	5.7	-2.4	0.7	-0.4
Neuroticism (2016)	1.1	1.7	2.7	0.5	-1.6	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.1	2.0	0.2	-0.5
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.7	1.7	-0.8	1.0
Neuroticism score	1.1	2.3	4.4	2.1	-1.2	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.4	0.3	0.9	-1.9
Medication: Paracetamol	1.1	1.7	4.3	2.1	-0.9	-0.4
Miserableness	1.1	1.8	4.9	2.2	0.0	-0.8
Ever taken oral contraceptive pill	1.1	1.2	3.5	-0.1	1.9	0.2
Hearing aid user	1.1	1.2	2.0	1.4	-0.3	1.3
Supplements: Calcium	1.1	1.2	3.5	-0.1	-0.4	1.9
Bipolar Disorder (2018)	1.0	1.5	4.0	2.0	-0.5	0.5
Lupus	1.0	1.5	2.7	1.1	0.7	-1.6
Hypothyroidism (self reported)	1.0	2.4	5.2	-1.3	2.3	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	3.3	0.6	1.7	-1.8
Diabetes (self-reported)	1.0	1.5	3.1	1.8	-1.0	0.6
Alcohol intake versus 10 years previously	1.0	1.6	2.2	-1.0	1.5	-1.3
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.4	-1.1	1.9	-1.0
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.3	-1.1	1.5	-0.0
Family relationship satisfaction	1.0	1.3	2.2	-0.7	1.5	-1.1
Eye problems/disorders: Cataract	1.0	1.2	2.0	1.1	-1.4	0.6
Medication: Paracetamol	1.0	1.5	2.8	1.7	-1.3	-0.4
Depressed Affect (Nagel 2018)	0.9	1.8	4.8	2.2	-0.3	0.8
Mean Putamen Volume	0.9	1.0	1.8	-0.8	1.3	-0.8
Respiratory disease	0.9	2.0	4.7	-0.2	1.1	-2.2
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.0	1.7	-1.4	-0.0
Ever had hysterectomy (womb removed)	0.9	1.0	2.9	-1.7	-0.3	0.2
Severe depression (siblings)	0.9	1.0	2.1	1.5	0.3	0.9
Number of live births	0.9	1.2	1.4	-1.2	1.1	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.4	1.6	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.7	7.0	1.0	-0.4	2.7
Medication for pain relief, constipation, heartburn	0.9	1.6	2.7	-1.7	1.4	0.4
Ever had bowel cancer screening	0.9	1.1	1.8	1.1	-1.3	0.6
Diabetes diagnosed by doctor	0.9	1.4	3.1	1.8	-1.0	0.4
Commuting to job workplace: Walk	0.9	1.0	3.0	0.2	-0.3	1.7
Medication for cholesterol	0.9	1.4	2.2	-1.5	1.1	0.9
Medication: Gliclazide	0.9	1.0	2.8	-0.4	-0.3	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	5.3	0.1	-0.5	2.3
Average weekly beer plus cider intake	0.9	1.4	2.3	-1.2	0.5	-1.5
Alzheimer’s Disease (in mother)	0.8	1.0	2.8	-0.2	0.1	-1.7
Reaction Time	0.8	1.5	4.4	2.1	-0.4	0.2
Ulcerative Colitis	0.8	1.1	3.1	-1.8	-0.4	0.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.1	1.8	-0.5	-0.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.5	-1.0	0.4	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.2	0.8	1.5	-1.0
Pulse wave reflection index	0.8	1.0	2.6	0.4	0.3	-1.6
Glaucoma (self-reported)	0.8	1.0	2.2	1.5	-0.5	-0.7
Medication: Amlodipine	0.8	1.2	2.7	-1.6	0.2	0.8
Birth weight	0.8	1.7	2.0	1.4	-1.4	-1.1
Osteoporosis (self-reported)	0.8	1.0	2.0	0.8	-0.6	1.4
Osteoarthritis (self-reported)	0.8	1.1	2.1	-0.9	1.5	-0.5
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.9	0.6	1.4	-0.7
Coronary Artery Disease (CAD)	0.7	0.8	1.3	1.1	-0.9	-0.7
Hearing difficulty/problems: Yes	0.7	1.1	1.6	1.3	-0.1	-1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	5.9	0.8	0.5	2.4
Depression (self-reported)	0.7	0.8	2.0	0.7	-1.4	0.0
Peak expiratory flow (PEF)	0.7	1.6	2.4	0.6	1.6	1.5
Exposure to tobacco smoke outside home	0.7	0.9	1.6	-0.3	-1.1	1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	2.8	1.7	0.6	-0.2
Ever depressed for a whole week	0.7	0.8	1.1	0.8	1.1	-0.8
Commuting to job workplace: Cycle	0.7	0.8	1.4	1.2	-1.0	-0.2
Schizophrenia (2014)	0.6	1.4	1.7	-1.2	1.0	-1.3
Number of treatments/medications taken	0.6	1.0	2.2	0.9	-0.1	-1.5
Impedance of leg (right)	0.6	3.0	4.9	-2.2	2.0	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.6	1.2	0.6	-1.6
Hair/balding pattern: Pattern 2	0.6	0.8	1.7	1.3	-0.8	0.3
Had other major operations	0.6	0.7	1.7	0.7	1.3	-0.2
Allergy	0.6	1.4	2.4	-1.4	1.6	-0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	1.6	-0.1	-1.3	1.2
Blood clot in the leg (DVT)	0.6	0.8	1.2	1.0	-1.1	0.3
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.8	0.1	1.3	-1.0
Gout (self-reported)	0.6	0.8	1.0	1.0	0.7	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.3	0.7	-1.1	0.4
Medication: Ibuprofen	0.6	0.7	1.8	-0.3	0.5	-1.3
Suffer from ‘nerves’	0.6	0.9	1.9	0.7	-1.4	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	0.9	0.8	0.9	-0.9
Supplements: Vitamin C	0.6	0.7	1.3	1.1	-0.6	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.2	-0.7	0.7	1.1
Number of self-reported non-cancer illnesses	0.6	1.0	2.5	1.6	-0.5	-0.7
Mother’s age at death	0.6	0.7	1.6	0.6	-0.3	-1.3
Financial situation satisfaction	0.6	0.8	1.9	-0.6	1.4	-0.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.7	1.3	-0.5	-0.0
Medication: Blood pressure	0.6	1.1	2.4	1.5	-1.0	0.0
Basal cell carcinoma (self-reported)	0.6	0.8	0.9	0.7	-0.9	0.9
Alzheimer’s Disease (including proxy)	0.5	0.7	1.7	-0.5	0.5	-1.3
Rheumatoid Arthritis	0.5	0.7	1.7	-0.4	1.3	-0.3
Allergy or Eczema	0.5	1.3	1.7	1.0	-1.3	1.0
Lung FVC	0.5	2.6	7.6	0.6	2.8	-0.1
Chronotype (morning person)	0.5	1.2	2.3	-0.6	1.5	-1.0
Average weekly spirits intake	0.5	0.6	1.3	0.6	0.4	-1.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.9	0.3	-0.1	-1.4
Systolic blood pressure, automated reading	0.5	1.4	2.3	-0.8	-1.5	1.1
Diabetes (mother)	0.5	0.7	1.9	0.3	0.1	1.4
Hand grip strength (right)	0.5	1.3	3.0	0.9	-0.3	1.7
Townsend deprivation index at recruitment	0.5	0.7	1.6	-1.3	0.7	-0.0
Fed-up feelings	0.5	1.0	2.3	1.5	0.3	0.7
Taking other prescription medications	0.5	0.8	1.2	1.1	0.7	-0.8
Serious illness, injury or assault to yourself	0.5	0.6	1.0	1.0	-0.7	-0.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.4	1.1	-0.8	1.2
Impedance of leg (left)	0.5	2.3	4.0	-2.0	1.7	0.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.2	0.7	0.3	1.1
Pain all over the body in last month	0.5	0.5	1.2	0.4	1.1	-0.4
Time employed in main current job	0.5	0.5	0.9	0.5	-0.9	0.7
Happiness	0.5	0.7	1.3	1.2	-0.3	0.7
Pulse wave Arterial Stiffness index	0.5	0.6	1.4	-0.6	0.3	-1.2
Forced vital capacity (FVC), Best measure	0.5	1.9	4.1	1.3	0.2	2.0
Wheeze or whistling in the chest in last year	0.5	0.9	2.3	0.6	-0.1	-1.5
Number of children fathered	0.5	0.6	1.0	1.0	0.8	0.1
Pulse wave peak to peak time	0.5	0.6	1.5	0.5	-0.3	1.2
Eye problems/disorders: None of the above	0.5	0.6	0.9	-0.9	1.0	-0.2
Mean time to correctly identify matches	0.5	1.0	2.7	1.6	-0.5	0.3
Had major operations	0.5	0.5	1.3	1.1	-0.1	-0.6
Age at last live birth	0.5	0.7	1.4	1.2	-0.3	-0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.3	1.1	-0.5	-0.1
Guilty feelings	0.5	0.7	1.6	1.3	-0.7	0.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	0.6	1.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.0	1.0	-1.0	0.3
Alcohol drinker status: Previous	0.5	0.6	1.5	-0.5	-0.3	1.2
Crohns Disease (2012)	0.4	0.7	1.3	0.0	-0.9	1.1
Blood Platelet Count	0.4	4.4	9.2	-1.5	1.3	-3.0
Current tobacco smoking	0.4	0.6	1.4	0.0	0.6	-1.2
Relative age voice broke	0.4	0.7	1.3	-0.2	-0.8	-1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.2	0.3	-1.1	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	0.4	-0.5	1.1
Hair/balding pattern: Pattern 3	0.4	0.5	1.5	-1.2	-0.3	-0.1
Pulse rate	0.4	0.7	1.4	0.4	-1.2	-0.8
Breastfed as a baby	0.4	0.5	1.2	0.4	0.3	-1.1
Tense / ‘highly strung’	0.4	0.6	1.0	-0.5	0.7	-1.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	1.0	-0.7	0.3
Health satisfaction	0.4	0.5	1.3	1.1	0.4	-0.4
Neck or shoulder pain in last month	0.4	0.6	1.1	1.1	-0.6	-0.6
Angina (self-reported)	0.4	0.5	1.3	0.4	-1.1	0.3
Mood swings	0.4	0.8	2.2	1.5	-0.2	0.3
Commuting to job workplace: Public transport	0.4	0.4	1.0	0.4	0.4	1.0
Pain experienced in last month	0.4	0.6	1.1	0.3	-1.1	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	0.9	-0.5	-0.6
Crohns Disease (2017)	0.3	0.6	1.1	0.5	-1.1	0.7
Systolic Blood Pressure	0.3	1.6	3.1	-1.8	-0.8	1.1
Hand grip strength (left)	0.3	0.7	1.0	0.6	0.9	1.0
Angina	0.3	0.4	1.0	0.4	-1.0	0.2
Medication: Metformin	0.3	0.4	0.8	0.9	-0.6	0.2
Had menopause	0.3	0.3	0.5	-0.7	-0.7	0.0
Forced vital capacity (FVC)	0.3	1.3	1.9	0.7	1.4	1.2
Financial difficulties in last 2 years	0.3	0.5	0.7	0.9	0.0	0.8
Mouth/teeth dental problems	0.3	0.5	0.7	-0.8	-0.4	0.7
Medication: Ramipril	0.3	0.3	0.6	0.2	-0.8	0.6
Medication: Simvastatin	0.3	0.4	1.1	1.0	0.1	-0.3
Fluid intelligence score	0.3	0.6	1.2	0.3	-1.1	0.8
Father’s age at death	0.3	0.4	1.0	0.4	-1.0	-0.2
Lung cancer (father)	0.3	0.3	0.8	0.0	0.9	0.5
Standing height	0.3	2.8	5.0	2.2	-1.2	1.4
Length of working week for main job	0.3	0.4	0.5	0.6	-0.3	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	1.0	0.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	0.4	0.8	0.6
Migraine (self-reported)	0.3	0.4	0.7	0.8	0.6	-0.2
Overall health rating	0.3	0.6	0.7	0.7	0.8	-0.8
Leg pain on walking	0.3	0.4	0.6	-0.7	-0.2	-0.8
Medication: Aspirin	0.3	0.3	0.8	-0.4	-0.9	0.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.5	-0.0	-0.6	0.7
Loneliness, isolation	0.3	0.4	0.5	0.3	0.7	-0.7
Medication: Aspirin	0.3	0.4	0.9	-0.5	-1.0	0.3
Fractured/broken bones in last 5 years	0.3	0.4	0.8	0.4	-0.3	0.9
Diastolic blood pressure, automated reading	0.3	0.9	1.3	-0.8	-1.1	0.9
Unable to work because of sickness or disability	0.3	0.4	1.0	0.5	-0.1	-1.0
Heart disease (siblings)	0.3	0.3	0.6	0.5	0.8	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	0.8	-0.3	0.9	-0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.5	0.1	0.5
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	-0.9	-0.6	0.6
LDL Cholesterol	0.2	0.3	0.4	-0.6	0.5	-0.5
Primary Biliary Cirrhosis	0.2	0.3	0.5	0.3	0.7	-0.6
Blood Eosinophil Count	0.2	1.9	4.5	-2.1	1.1	0.0
Blood White Count	0.2	1.5	2.6	-0.5	1.6	-1.3
Height	0.2	4.1	9.3	3.0	-1.2	1.2
Medication for hormone replacement therapy	0.2	0.2	0.6	0.0	-0.8	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.8	-0.9	-0.3	0.2
Sitting height	0.2	1.2	1.5	1.1	1.2	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	1.0	-0.2	-0.0
Heart attack	0.2	0.3	0.5	0.7	-0.3	-0.4
Asthma	0.2	0.3	0.6	0.3	-0.6	-0.8
Medication: Cholesterol lowering	0.2	0.3	0.3	-0.4	0.6	-0.6
Medication: Lansoprazole	0.2	0.2	0.4	0.4	0.4	0.6
Hair/balding pattern: Pattern 4	0.2	0.6	1.4	0.3	1.2	0.6
Friendships satisfaction	0.2	0.2	0.4	-0.7	-0.1	0.5
Smoking status: Current	0.2	0.3	0.7	0.5	-0.3	-0.8
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.7	0.1	0.5
Medication: Lisinopril	0.2	0.2	0.4	0.6	-0.4	-0.2
Alcohol drinker status: Never	0.2	0.3	0.6	0.4	0.0	-0.8
Myopia	0.2	0.3	0.6	0.8	-0.4	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.4	0.1	0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.7	-0.2	0.4
Fasting Glucose	0.1	0.1	0.2	0.1	0.4	-0.4
HDL Cholesterol	0.1	0.2	0.4	0.1	0.6	-0.3
Triglycerides	0.1	0.1	0.2	0.3	0.4	0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.2	-0.3	-0.5
Heel T-Score	0.1	1.2	2.1	0.7	1.4	-1.0
Relative age of first facial hair	0.1	0.3	0.6	-0.5	0.0	-0.8
Prospective memory result	0.1	0.1	0.2	-0.3	-0.2	-0.4
Birth weight of first child	0.1	0.2	0.5	0.4	0.3	-0.7
Loud music exposure frequency	0.1	0.1	0.2	-0.5	0.2	0.1
Headache pain in last month	0.1	0.2	0.4	-0.3	0.3	-0.7
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.3	0.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	-0.2	-0.3	0.3
Comparative height size at age 10	0.1	0.6	1.1	0.9	0.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.1	0.4	-0.3
Illnesses of father: Heart disease	0.1	0.2	0.4	-0.1	-0.7	0.3
Asthma (self-reported)	0.1	0.3	0.5	0.3	-0.5	-0.7
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.2	-0.5	-0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.2	0.4	-0.1	-0.5	0.6
Hair Pigment	0.0	0.3	0.5	-0.4	0.7	-0.3
Tanning	0.0	0.5	1.1	0.2	-0.5	-1.1
Stomach or abdominal pain in last month	0.0	0.0	0.0	0.1	-0.1	-0.2
Number of incorrect matches in round	0.0	0.1	0.2	0.4	0.2	-0.0
Comparative body size at age 10	0.0	0.1	0.3	0.2	-0.0	-0.5
Pulse rate, automated reading	0.0	0.1	0.2	0.5	-0.1	0.2
Knee pain experienced in last month	0.0	0.0	0.0	0.0	-0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.2	-0.0	0.4
Breast cancer (self-reported)	0.0	0.0	0.1	0.0	-0.4	0.1
Irritability	0.0	0.1	0.1	0.1	-0.2	0.4

Hub : Genes

PDZRN4

Models

Trait associations