Hub : Genes

PEX2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.320	0.094	0.00054	0.056	NA	0.114	NA	0.103	9.6e-03	NA	3.0e-04	NA	5.9e-04
2	GTEx	Cells Transformed fibroblasts	0.118	0.054	0.00540	0.123	NA	0.080	NA	0.103	1.9e-09	NA	1.3e-06	NA	3.8e-08
3	GTEx	Skin Sun Exposed Lower leg	0.096	0.035	0.00090	0.028	NA	0.056	NA	0.045	2.0e-03	NA	2.1e-05	NA	1.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	1.0	2.3	1.5	-0.4	0.7
Bipolar Disorder or Schizophrenia	0.2	0.6	0.9	0.9	-0.1	-0.9
Depressed Affect (Nagel 2018)	0.4	0.9	1.4	-1.2	0.8	-0.7
Depression (Nagel 2018)	0.1	0.2	0.5	-0.7	0.1	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.6	0.3	-0.7	0.8
Neuroticism (Nagel 2018)	0.2	0.5	1.5	0.3	0.2	-1.2
Schizophrenia (2018)	0.5	1.1	3.2	-0.0	0.3	-1.8
Schizophrenia vs Biploar Disorder	0.5	0.7	1.0	-1.0	-0.8	-0.5
Worry (Nagel 2018)	0.3	0.5	1.5	1.2	0.1	-0.4
Alzheimer’s Disease (in mother)	0.5	0.6	1.6	-1.3	0.4	-0.3
Alzheimer’s Disease (in father)	1.1	1.2	2.1	-0.5	1.4	1.1
Alzheimer’s Disease (including proxy)	1.5	2.2	3.9	-2.0	1.6	0.6
Crohns Disease (2017)	0.1	0.3	0.6	-0.5	-0.8	-0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.4	-0.4	-1.2	0.0
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.5	-0.6	-0.1
Major Depression (MDD)	0.8	0.9	2.2	1.5	-0.8	-0.3
Reaction Time	0.4	0.7	1.2	0.9	-1.1	-0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	0.2	0.3	1.0
Breast Cancer	1.0	2.4	4.9	-2.2	-1.0	1.1
Ovarian Cancer	0.4	0.6	1.7	0.2	-0.2	1.3
Prostate Cancer	0.5	0.7	1.5	-0.8	-0.2	-1.2
Age at First Birth	0.3	0.4	0.4	-0.6	0.7	-0.6
Bipolar Disorder (2011)	1.2	1.2	3.5	-0.4	1.9	-0.1
Body Mass Index (BMI) (2010)	0.6	0.8	1.8	-0.7	1.3	0.5
Coronary Artery Disease (CAD)	0.9	1.1	3.2	0.2	-0.3	-1.8
Crohns Disease (2012)	0.3	0.6	1.7	-0.1	-1.3	-0.1
Mean Putamen Volume	0.4	0.5	0.8	-0.8	-0.1	-0.9
Fasting Glucose	1.6	2.0	3.5	-1.4	0.7	-1.9
HbA1C	0.6	0.6	1.6	-0.5	1.2	-0.2
HDL Cholesterol	0.6	1.1	2.0	1.0	-1.4	0.3
LDL Cholesterol	0.5	0.7	1.2	0.3	1.0	1.1
Lupus	0.2	0.2	0.4	-0.6	-0.1	0.6
Neuroticism (2016)	0.2	0.3	0.5	-0.2	0.6	0.7
Primary Biliary Cirrhosis	1.7	2.4	3.4	-0.8	-1.8	-1.8
Rheumatoid Arthritis	0.8	1.1	2.2	0.9	-1.5	0.6
Schizophrenia (2014)	0.8	1.7	2.0	1.0	-1.4	-1.4
Triglycerides	0.9	1.5	2.6	1.6	-0.9	1.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.6	1.2	-1.1	0.2
Ulcerative Colitis	0.2	0.4	0.9	0.1	-1.0	0.4
Blood Eosinophil Count	0.0	0.3	0.4	-0.6	-0.2	-0.7
Blood Platelet Count	0.2	1.9	3.6	1.9	-1.3	-0.4
Blood Red Count	0.0	0.2	0.5	0.1	-0.7	-0.5
Blood White Count	0.6	4.3	10.1	-1.4	-0.8	-3.2
Heel T-Score	0.5	3.7	7.6	2.8	-0.5	-1.8
BMI	0.1	0.6	1.0	-0.8	-0.2	-1.0
Height	0.7	13.7	20.5	4.4	1.0	-4.5
Waist Hip Ratio (WHR)	0.5	2.3	3.6	1.6	-1.9	-0.7
Systolic Blood Pressure	0.2	0.8	1.4	-0.7	1.2	0.7
Smoking Status	0.2	0.4	0.8	0.9	-0.1	0.7
Allergy or Eczema	0.5	1.4	2.7	0.5	-1.6	-1.1
Cardiovascular Disease	0.1	0.3	0.9	-1.0	-0.1	0.3
Hypothyroidism (self reported)	0.8	1.7	3.8	1.1	0.3	1.9
Respiratory disease	0.5	1.2	2.0	-1.4	-0.9	-0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.4	0.4	1.2	-0.1
Lung FEV1/FVC ratio	0.5	2.7	3.7	1.2	-1.7	-1.9
Lung FVC	0.1	0.4	0.9	1.0	-0.4	0.3
Neuroticism	0.0	0.1	0.2	0.5	0.2	0.1
Chronotype (morning person)	0.2	0.5	0.9	-0.4	-0.6	-1.0
Hair Pigment	0.0	1.1	2.2	-1.0	-0.3	1.5
Tanning	0.1	1.8	2.4	1.3	1.6	1.2
Hand grip strength (left)	0.4	1.1	1.8	0.5	1.3	-1.2
Number of treatments/medications taken	0.2	0.4	0.8	-0.9	-0.6	0.2
Average weekly spirits intake	1.1	1.4	2.2	1.0	1.0	1.5
Sensitivity / hurt feelings	0.0	0.1	0.1	0.3	0.1	-0.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.9	-1.4	-0.5	-0.2
Hearing difficulty/problems: Yes	0.5	0.8	1.8	-0.7	-1.4	0.0
Relative age of first facial hair	2.1	4.3	7.9	-2.8	-1.2	-2.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.5	-1.6	0.4	0.9
Ever used hormone-replacement therapy (HRT)	1.9	2.4	6.8	-2.6	-0.6	-0.3
Ever had hysterectomy (womb removed)	0.1	0.2	0.4	-0.2	-0.0	0.6
Systolic blood pressure, automated reading	0.1	0.3	0.4	0.1	0.6	0.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.1	-1.0	0.1	-0.9
Angina	0.0	0.0	0.1	-0.3	0.0	0.0
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.0	-0.4	-0.1
Vitamin and mineral supplements	0.3	0.4	0.7	-0.8	0.2	-0.7
Supplements: Zinc	0.1	0.1	0.3	-0.0	-0.6	-0.0
Medication: Co-codamol	1.5	1.8	3.3	-0.3	1.8	-1.4
Medication: Metformin	0.3	0.4	0.6	0.2	-0.8	-0.8
Diabetes (father)	0.4	0.6	1.4	0.1	-0.5	-1.2
Diabetes (mother)	0.5	0.6	1.4	0.3	-1.2	-0.6
Severe depression (siblings)	0.4	0.5	0.7	-0.0	0.8	-0.9
Pack years adult smoking proportion	0.1	0.2	0.3	0.5	-0.4	-0.5
Impedance of leg (right)	0.2	0.8	1.6	0.0	0.9	1.3
Leg fat-free mass (left)	0.7	3.9	11.0	0.8	-0.1	-3.3
Trunk fat percentage	0.4	1.8	3.1	-1.4	-0.5	-1.8
Hand grip strength (right)	0.9	2.6	6.3	2.5	1.0	-0.7
Townsend deprivation index at recruitment	0.4	0.6	1.2	-0.6	-0.4	-1.1
Current tobacco smoking	1.4	2.4	3.9	-1.3	2.0	-1.2
Average weekly fortified wine intake	0.3	0.3	0.9	0.2	-0.0	-0.9
Maternal smoking around birth	0.9	1.3	1.8	-1.3	0.5	-1.4
Fed-up feelings	0.3	0.5	1.0	-1.0	-0.2	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	3.2	4.3	5.4	-2.3	1.7	-2.1
Relative age voice broke	1.7	2.6	5.0	-2.2	-0.7	-1.5
Taking other prescription medications	1.0	1.6	4.3	-2.1	-0.2	-0.6
Age when periods started (menarche)	0.8	1.9	5.6	-2.4	-0.0	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.6	0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.5	0.7	0.3	0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.0	-0.4	0.9	1.0
Qualifications: CSEs or equivalent	0.2	0.3	0.8	0.9	0.0	-0.3
Serious illness, injury or assault to yourself	2.9	3.6	7.3	-2.7	1.7	-0.6
High blood pressure	0.8	2.1	5.7	-2.4	0.7	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	0.5	-0.4	-0.3
Multivitamins +/- minerals	0.7	0.9	1.2	0.6	1.0	1.1
Stomach or abdominal pain in last month	1.7	2.1	4.9	-1.2	2.2	-0.3
Supplements: Glucosamine	0.2	0.2	0.4	-0.6	0.4	-0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.4	0.1	1.5	-0.1
Medication: Atenolol	1.1	1.4	3.0	-1.0	0.0	-1.7
Medication: Levothyroxine sodium	0.4	0.7	1.0	0.9	-0.5	1.0
Sitting height	1.2	8.6	12.9	3.6	0.7	-3.5
Chronic bronchitis/emphysema (father)	1.9	2.3	4.2	-2.0	-0.8	-1.4
High blood pressure (mother)	0.3	0.4	1.2	0.2	0.3	-1.1
Body mass index (BMI)	0.2	0.9	1.3	-1.1	-0.2	-1.2
Impedance of leg (left)	0.1	0.7	1.3	-0.5	1.1	0.6
Leg predicted mass (left)	0.7	3.9	11.1	0.8	-0.2	-3.3
Trunk fat mass	0.5	2.0	5.1	-0.9	-0.1	-2.3
Waist circumference	0.3	1.2	3.2	-0.2	-0.7	-1.8
Number of incorrect matches in round	0.5	0.9	2.5	-0.4	1.6	0.3
Past tobacco smoking	1.5	2.8	4.5	-2.1	-0.3	-1.9
Alcohol usually taken with meals	0.7	1.2	1.8	1.3	-1.4	-0.3
Nervous feelings	0.7	1.4	4.0	0.1	-0.4	-2.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.0	-1.4	-0.1	-0.8
Hearing difficulty/problems with background noise	0.4	0.6	0.7	-0.7	0.8	0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	0.4	1.0	0.2
Had menopause	0.5	0.6	1.2	-1.1	0.4	0.7
Had other major operations	0.9	1.1	2.8	-0.4	1.7	-0.6
Forced vital capacity (FVC)	0.8	3.0	4.9	2.2	-1.1	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	0.4	0.4	-0.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.1	-0.5	-1.5	-0.2
Qualifications: None of the above	0.2	0.4	0.6	0.6	-0.8	-0.4
Financial difficulties in last 2 years	2.1	2.8	5.9	-1.6	-0.1	-2.4
Mouth/teeth dental problems	0.6	0.9	1.5	-0.6	-1.2	0.9
Heart attack	1.5	1.9	4.2	-2.1	0.7	1.0
Allergy	0.1	0.3	0.6	0.8	0.3	0.3
Pain all over the body in last month	0.3	0.3	0.5	-0.7	-0.7	0.3
Diabetes (self-reported)	0.3	0.5	1.4	-0.2	1.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.0	-0.6	-0.8	1.0
Medication: Ramipril	0.7	0.8	1.8	-0.6	-1.4	-0.6
Medication: Simvastatin	0.1	0.2	0.3	0.5	-0.4	0.2
Fluid intelligence score	0.4	0.9	2.2	-0.0	0.6	1.5
Illnesses of siblings	0.8	1.1	3.2	-0.0	0.2	-1.8
Neuroticism score	0.2	0.4	0.7	-0.1	0.9	-0.6
Weight	0.5	2.6	7.6	0.1	0.2	-2.8
Impedance of arm (right)	0.1	0.3	0.5	-0.3	-0.7	-0.4
Arm fat percentage (right)	0.4	1.6	2.5	-1.6	-0.5	-1.4
Trunk fat-free mass	0.7	4.1	6.4	2.4	0.5	-2.5
Hip circumference	0.3	1.3	3.5	-0.2	-0.6	-1.9
Time employed in main current job	1.3	1.4	3.7	-0.4	-1.9	-0.7
Alcohol intake versus 10 years previously	0.7	1.1	2.2	-0.9	1.5	0.3
Father’s age at death	0.5	0.7	2.0	-0.5	0.1	-1.4
Worrier / anxious feelings	0.1	0.2	0.4	0.6	0.3	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	-0.6	0.4	1.0
Falls in the last year	2.0	2.7	6.9	-2.6	0.3	-1.1
Hair/balding pattern: Pattern 3	0.7	1.0	2.2	-1.0	-0.1	-1.5
Number of live births	0.2	0.3	0.9	0.1	-0.2	0.9
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	5.8	2.4	-1.5	-1.7
Pulse rate	0.1	0.2	0.7	-0.1	-0.0	-0.8
Happiness	0.1	0.2	0.2	0.4	-0.4	0.5
Noisy workplace	0.9	1.1	2.2	-0.6	0.9	-1.5
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.4	0.1	-0.4	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.3	-1.8	1.1	0.2
Mouth/teeth dental problems: Dentures	0.2	0.3	0.9	-0.2	1.0	-0.2
Asthma	1.2	2.3	5.9	-2.4	0.0	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.8	0.3	0.9	-0.4
Medication: Cholesterol lowering	0.9	1.4	1.8	-1.0	1.2	1.4
Depression (self-reported)	0.6	0.7	1.1	-1.1	0.9	-0.5
Medication: Lansoprazole	0.4	0.5	1.1	-0.0	-0.6	-1.1
Prospective memory result	0.7	0.8	1.6	0.4	-1.2	-0.9
Lung cancer (father)	0.5	0.6	1.1	-1.1	-0.1	-0.7
Illnesses of mother	0.0	0.0	0.1	0.2	-0.0	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	8.1	2.8	-1.6	-1.7
Pulse wave Arterial Stiffness index	2.3	2.7	5.9	1.0	-2.4	-1.1
Impedance of arm (left)	0.1	0.2	0.6	0.2	-0.8	0.2
Arm fat mass (right)	0.4	1.6	4.2	-0.8	-0.3	-2.1
Trunk predicted mass	0.7	4.2	6.4	2.5	0.5	-2.5
Standing height	0.9	8.7	16.1	3.0	0.9	-4.0
Length of working week for main job	0.7	0.7	1.4	1.2	-0.1	0.9
Exposure to tobacco smoke at home	0.3	0.3	1.0	-1.0	0.1	-0.1
Breastfed as a baby	1.2	1.4	3.6	-1.9	0.3	0.8
Tense / ‘highly strung’	0.5	0.8	2.2	1.5	-0.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.9	-0.4	1.7	-0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	0.1	0.7	-0.5
Birth weight of first child	1.4	2.5	7.3	-0.4	0.2	-2.7
Peak expiratory flow (PEF)	0.9	2.2	3.4	1.4	-1.1	-1.9
Pulse wave reflection index	0.4	0.5	1.0	-0.6	-1.0	0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	-0.1	-1.0	-0.4
Loud music exposure frequency	0.4	0.5	1.0	-0.1	-1.0	0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	1.2	-0.2	-0.0
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.7	1.6	-0.1	0.4
Blood clot in the leg (DVT)	0.6	0.7	1.1	-1.0	0.7	-0.8
Medication: Paracetamol	0.5	0.8	1.5	-0.8	-1.2	-0.5
Headache pain in last month	0.2	0.4	0.9	-0.9	0.4	-0.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	2.5	1.3	-0.6	-1.6
Glaucoma (self-reported)	0.5	0.6	1.0	0.0	-1.0	0.9
Gout (self-reported)	3.9	5.3	10.0	-2.5	3.2	0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.8	0.9	0.3	1.7
Medication: Amlodipine	1.1	1.5	2.9	-1.3	-1.7	0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	0.1	0.2	-0.8
Birth weight	0.3	0.6	1.7	-1.3	0.3	0.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.7	-0.7	0.0
High blood pressure (siblings)	0.2	0.3	0.5	0.5	-0.7	0.1
Forced vital capacity (FVC), Best measure	1.1	3.8	7.7	2.8	-1.0	-1.7
Body fat percentage	0.5	1.8	2.7	-1.7	-0.5	-1.6
Leg fat percentage (right)	0.4	1.3	3.2	-1.8	0.1	-0.8
Arm fat-free mass (right)	0.6	3.3	7.2	1.4	0.8	-2.7
Exposure to tobacco smoke outside home	0.4	0.5	0.9	0.6	-0.5	-0.9
Comparative body size at age 10	0.3	0.7	1.6	-1.3	-0.3	0.6
Number of full brothers	1.0	1.2	2.0	-1.0	-0.8	-1.4
Worry too long after embarrassment	0.4	0.7	2.0	1.4	0.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.3	-0.9	1.5	0.7
Wheeze or whistling in the chest in last year	0.7	1.2	2.3	-1.5	1.1	0.3
Number of children fathered	1.3	1.4	3.3	0.7	-0.6	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.2	-0.6	0.5
Age at first live birth	0.8	1.4	1.9	1.2	1.4	0.9
Pulse wave peak to peak time	2.0	2.4	5.8	-0.8	2.4	0.9
Health satisfaction	0.8	1.0	1.7	-1.1	1.3	0.2
Shortness of breath walking on level ground	0.6	0.7	0.9	-0.9	-0.7	0.9
Qualifications: College or University degree	0.1	0.2	0.4	-0.1	-0.6	0.6
Eye problems/disorders: None of the above	1.1	1.3	2.3	-1.5	1.1	-0.7
Mouth/teeth dental problems: Loose teeth	2.1	2.5	4.3	0.7	-1.6	-2.1
Emphysema/chronic bronchitis	0.6	0.7	1.6	0.6	-0.2	1.3
Medication for pain relief, constipation, heartburn	0.2	0.4	0.6	0.8	-0.5	0.6
Neck or shoulder pain in last month	1.1	1.5	3.6	-0.3	-0.9	-1.9
Medication: Blood pressure	0.8	1.4	3.4	-1.8	0.1	0.8
Angina (self-reported)	0.2	0.2	0.5	-0.7	0.5	-0.1
Migraine (self-reported)	0.2	0.2	0.5	0.0	-0.7	0.4
Medication: Ibuprofen	0.8	1.0	1.4	1.2	1.2	-0.3
Medication: Allopurinol	1.3	1.7	2.6	-1.6	1.0	1.2
Medication: Omeprazole	3.1	3.7	7.4	-1.8	2.7	0.5
Medication: Seretide 50 evohaler	0.6	0.7	0.8	-0.9	-0.8	-0.8
Mean time to correctly identify matches	0.3	0.6	1.4	0.7	-1.2	-0.0
Heart disease (mother)	0.6	0.7	1.7	0.4	-0.4	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	3.7	-0.9	1.6	1.9
Whole body fat mass	0.6	2.3	6.0	-1.0	-0.2	-2.5
Leg fat mass (right)	0.4	1.6	3.6	-1.1	0.2	-1.9
Arm predicted mass (right)	0.5	2.8	6.1	1.2	0.8	-2.5
Pulse rate, automated reading	0.1	0.3	0.9	0.2	-0.9	-0.2
Alcohol intake frequency.	0.4	1.0	1.5	-1.2	1.1	0.4
Comparative height size at age 10	1.3	7.1	14.2	2.4	1.1	-3.8
Number of full sisters	0.2	0.2	0.6	-0.0	-0.1	-0.8
Suffer from ‘nerves’	0.2	0.3	0.5	-0.3	0.6	-0.7
Overall health rating	1.5	3.3	7.7	-2.8	1.2	-0.8
Chest pain or discomfort	0.2	0.3	1.0	-1.0	-0.0	-0.2
Had major operations	1.4	1.6	3.3	0.8	1.8	1.0
Age at last live birth	0.2	0.3	0.5	0.7	0.6	0.4
Family relationship satisfaction	1.1	1.4	2.9	-1.1	-1.7	-0.1
Leg pain on walking	0.2	0.2	0.5	-0.1	-0.4	0.7
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	3.7	-1.9	1.5	-1.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.9	0.9	0.2	-1.0
Illness, injury, bereavement, stress in last 2 years	3.8	4.6	6.3	2.2	-2.5	1.7
Medication: Aspirin	0.1	0.1	0.1	-0.2	-0.3	0.4
Supplements: Vitamin C	0.6	0.7	1.5	0.0	-0.7	-1.2
Knee pain experienced in last month	0.7	1.1	2.0	1.4	0.8	-0.7
Hypertension (Self-reported)	0.9	2.5	6.4	-2.5	0.9	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	4.3	0.1	1.1	2.1
Illnesses of father: Heart disease	0.9	1.3	1.5	1.1	-1.2	1.1
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.2	-0.4	0.5
Smoking status: Previous	3.2	4.8	7.6	2.8	-0.6	2.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.9	1.0	-0.5	-1.4
Whole body fat-free mass	0.7	4.1	9.2	1.7	0.4	-3.0
Leg fat-free mass (right)	0.8	4.3	12.4	0.7	-0.1	-3.5
Arm fat percentage (left)	0.3	1.2	1.8	-1.4	-0.5	-1.2
Average weekly red wine intake	1.6	2.4	4.6	0.7	-2.1	-1.5
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.0	-1.4	0.9	0.3
Mood swings	0.7	1.2	2.1	-1.1	1.4	-0.6
Loneliness, isolation	0.9	1.3	3.3	-0.6	1.8	-0.4
Long-standing illness, disability or infirmity	1.7	2.6	6.1	-2.5	0.2	-1.3
Ever had bowel cancer screening	0.1	0.1	0.2	0.4	0.4	0.2
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.1	0.5	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.2	-0.8	0.2	-1.5
Friendships satisfaction	0.7	0.8	1.6	1.3	0.9	-0.1
Qualifications: nursing, teaching	0.7	1.1	2.7	0.7	1.6	0.4
Commuting to job workplace: Walk	0.5	0.5	1.1	1.0	-0.7	-0.2
Eye problems/disorders: Cataract	0.7	0.8	1.6	1.3	-0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.9	0.1	0.8	-1.7
Medication for cholesterol	0.1	0.2	0.4	-0.0	0.6	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.7	0.4	0.0
Back pain experienced in last month	1.0	1.4	1.9	-1.3	0.8	-1.4
Mineral and other dietary supplements	0.1	0.2	0.4	0.6	-0.1	-0.4
Breast cancer (self-reported)	0.6	0.7	1.3	-0.1	-1.2	-0.9
Asthma (self-reported)	1.2	2.3	5.1	-2.3	0.3	-1.3
Osteoporosis (self-reported)	0.5	0.6	1.6	0.1	-1.3	0.6
Osteoarthritis (self-reported)	0.7	0.9	2.3	-0.2	-0.6	-1.5
Medication: Aspirin	0.5	0.6	1.6	-0.0	-0.5	1.3
Medication: Gliclazide	0.2	0.2	0.3	0.3	0.5	-0.5
Illnesses of father: None of the above (group 1)	0.7	0.8	2.3	-0.5	1.5	0.1
Smoking status: Current	0.9	1.4	2.8	-1.0	1.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.9	0.8	-1.4	-1.0
Whole body water mass	0.7	3.8	8.8	1.6	0.4	-3.0
Leg predicted mass (right)	0.8	4.5	12.9	0.7	-0.1	-3.6
Arm fat mass (left)	0.4	1.7	4.3	-0.8	-0.3	-2.1
Number of self-reported non-cancer illnesses	1.7	3.0	7.1	-2.7	1.3	-0.1
Average weekly champagne plus white wine intake	0.8	1.1	2.0	1.0	-0.4	-1.4
Miserableness	1.0	1.7	2.6	-1.6	1.5	-0.5
Guilty feelings	0.9	1.4	4.0	0.1	-0.2	-2.0
Wears glasses or contact lenses	0.8	0.9	1.6	0.6	-1.3	-0.8
Ever taken oral contraceptive pill	0.8	0.9	2.4	1.5	-0.1	0.7
Hearing aid user	0.1	0.1	0.3	0.1	-0.6	0.1
Mother’s age at death	1.1	1.3	3.8	0.4	-2.0	-0.1
Financial situation satisfaction	0.0	0.0	0.1	0.1	0.2	-0.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.3	1.1	-0.6	1.0
Commuting to job workplace: Public transport	0.4	0.5	0.7	-0.8	0.5	0.7
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	-0.6	-0.6	1.1
Medication: Blood pressure	0.2	0.4	0.9	-1.0	-0.2	0.3
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.6	-1.9	-0.1	-0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	-0.4	0.3	1.1
High cholesterol (Self-reported)	0.3	0.5	1.4	0.3	-0.2	1.2
Medication: Bendroflumethiazide	0.3	0.5	1.4	-1.2	-0.0	-0.4
Medication: Paracetamol	0.6	0.9	2.2	-0.6	-1.5	-0.2
Medication: Lisinopril	0.3	0.3	0.3	-0.6	0.6	0.6
Medication: Atorvastatin	1.2	1.5	2.6	-0.4	1.6	1.3
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.5	0.4	-0.2
Alcohol drinker status: Never	1.3	1.6	2.7	0.9	1.1	1.6
Ever smoked	0.3	0.5	1.4	1.2	0.5	-0.0
Basal metabolic rate	0.7	3.8	9.6	1.3	0.3	-3.1
Leg fat percentage (left)	0.6	2.1	4.9	-2.2	0.3	-1.2
Arm fat-free mass (left)	0.7	3.5	9.0	1.2	0.3	-3.0
Number of operations (self-reported)	1.2	1.8	5.0	0.6	2.2	0.5
Average weekly beer plus cider intake	0.2	0.2	0.5	-0.7	0.4	0.2
Irritability	0.3	0.5	1.3	1.1	-0.2	0.2
Risk taking	0.5	0.7	1.4	0.0	-0.8	-1.2
Ever had prostate specific antigen (PSA) test	2.3	2.7	6.1	0.0	-1.4	2.5
Fractured/broken bones in last 5 years	7.2	9.2	24.3	-4.9	1.6	-0.9
Age started oral contraceptive pill	0.7	0.9	1.2	-0.7	1.0	-1.1
Diastolic blood pressure, automated reading	0.6	1.7	3.9	2.0	0.1	-1.1
Ever depressed for a whole week	0.1	0.1	0.3	0.6	0.1	-0.2
Unable to work because of sickness or disability	5.0	6.4	10.7	-2.9	0.0	-3.3
Commuting to job workplace: Cycle	1.1	1.3	2.5	-1.6	-0.2	-1.2
Myopia	0.8	1.2	2.2	-1.0	1.5	-0.6
Vascular/heart problems diagnosed by doctor	1.1	2.9	8.1	2.9	-0.8	-0.1
Cholesterol lowering medication	0.2	0.3	0.8	0.5	-0.9	-0.2
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	8.4	-0.9	2.9	0.4
Pain experienced in last month	1.3	2.1	3.0	1.1	-1.4	1.7
Supplements: Calcium	0.5	0.5	1.3	-0.2	-0.4	1.2
Basal cell carcinoma (self-reported)	1.7	2.0	2.9	-1.7	0.5	-1.6
Heart attack/myocardial infarction (self-reported)	2.0	2.5	5.1	-2.2	0.9	1.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.2	-1.1	0.8	-0.7
Heart disease (siblings)	2.1	2.6	4.4	-0.7	1.7	2.1
Alcohol drinker status: Previous	1.5	1.8	3.2	-1.0	1.0	-1.8
Pack years of smoking	0.1	0.2	0.4	0.5	-0.6	0.1
Impedance of whole body	0.0	0.0	0.1	0.1	-0.0	0.3
Leg fat mass (left)	0.5	2.0	4.1	-1.3	0.3	-2.0
Arm predicted mass (left)	0.7	3.3	8.3	1.1	0.7	-2.9