TWAS hub - PHLPP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1790	0.0590	9.9e-04	0.105	NA	0.051	NA	0.080	2.1e-06	NA	8.8e-04	NA	3.3e-05
2	GTEx	Cells Transformed fibroblasts	0.4180	0.0550	0.0e+00	0.385	NA	0.372	NA	0.397	2.0e-30	NA	3.3e-29	NA	1.4e-31
3	GTEx	Esophagus Muscularis	0.1870	0.0580	3.9e-04	0.070	NA	0.120	NA	0.109	4.7e-05	NA	1.0e-07	NA	4.0e-07
4	GTEx	Muscle Skeletal	0.1168	0.0364	2.3e-04	0.081	NA	0.050	NA	0.075	2.3e-08	NA	1.2e-05	NA	8.5e-08
5	GTEx	Testis	0.2090	0.0610	3.9e-04	0.112	NA	0.214	NA	0.217	1.1e-05	NA	7.0e-10	NA	5.4e-10
6	NTR	Blood	0.0357	0.0096	1.2e-06	0.023	0.022	0.027	0.029	0.025	3.4e-08	7.6e-08	2.9e-09	1.1e-09	9.9e-09
7	YFS	Blood	0.0386	0.0105	2.5e-07	0.023	0.024	0.032	0.026	0.033	4.5e-08	1.9e-08	1.2e-10	4.0e-09	5.1e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Risk taking	6.1	8.9	13.2	-2.8	-3.3	-3.6	-2.6	-3.4	-2.7	-2.2
Other serious medical condition/disability diagnosed by doctor	5.0	6.4	14.0	-3.2	-3.7	-3.0	-1.6	-1.5	1.4	2.2
Qualifications: CSEs or equivalent	4.5	5.9	13.0	2.1	2.3	3.6	2.8	3.3	0.5	0.3
Long-standing illness, disability or infirmity	3.8	5.8	8.7	-2.9	-2.9	-2.9	-2.8	-0.9	1.9	1.7
Severe depression (siblings)	3.6	4.0	7.8	-2.8	-2.5	-1.7	-2.6	-2.0	-0.6	-0.5
Falls in the last year	3.6	4.8	9.4	-2.5	-2.6	-1.1	-1.1	-3.1	-1.9	-2.3
Hearing difficulty/problems with background noise	3.5	5.5	16.4	-1.5	-2.0	-2.3	-1.4	0.3	4.0	2.9
Ever highly irritable/argumentative for 2 days	3.5	4.2	9.5	-3.1	-2.4	-1.9	-2.1	-1.4	1.5	1.4
Number of self-reported non-cancer illnesses	3.5	6.1	14.6	-2.7	-2.6	-3.8	-1.6	-0.5	2.5	2.2
Tinnitus: Yes, but not now, but have in the past	3.4	3.6	7.8	-2.8	-2.0	-1.8	-2.3	-2.2	-0.7	-0.1
Leg pain on walking	3.3	4.1	9.5	-3.1	-2.5	-2.0	-2.5	-1.7	0.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	3.1	3.6	9.1	-3.0	-1.4	-2.8	-1.2	-1.8	0.6	1.1
Frequency of tiredness / lethargy in last 2 weeks	3.0	4.9	8.3	-2.9	-2.8	-2.1	-2.6	-1.8	1.5	1.0
Rheumatoid Arthritis	2.8	3.9	7.2	1.7	2.5	2.5	2.7	1.7	1.0	0.9
Illnesses of mother	2.8	3.5	7.6	2.8	2.4	1.7	1.2	2.4	0.6	0.6
Osteoarthritis (self-reported)	2.8	3.6	8.5	-2.3	-2.9	-2.6	-1.4	-1.5	-0.6	-0.3
Medication: Ramipril	2.7	3.5	12.9	-0.4	-0.4	-0.4	-0.3	-2.2	-2.4	-3.6
Osteoporosis (self-reported)	2.7	3.4	5.8	1.6	2.0	1.8	0.1	2.4	2.1	1.9
Medication: Metformin	2.6	3.7	7.9	-2.1	-2.8	-2.3	-0.8	-1.1	1.7	2.0
Medication for pain relief, constipation, heartburn	2.6	4.4	6.1	2.2	2.3	2.5	1.9	2.1	2.0	1.5
Family relationship satisfaction	2.6	3.2	6.7	-2.2	-2.1	-2.6	-1.1	-2.1	0.8	-0.5
Pain type(s) experienced in last month: Hip pain	2.6	3.3	8.0	-2.8	-2.2	-2.4	-0.8	-1.9	-0.6	-0.2
Number of treatments/medications taken	2.5	4.5	10.6	-2.4	-2.4	-3.3	-2.5	-1.1	0.9	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.3	7.8	-2.8	-2.0	-0.8	-1.0	-1.4	2.1	1.7
Handedness (chirality/laterality): Left-handed	2.5	3.0	6.3	2.5	1.4	1.3	1.8	2.5	0.8	1.1
Alzheimer’s Disease (in father)	2.4	2.6	9.8	-0.8	-0.7	-1.8	-0.1	0.8	3.1	1.9
Ever used hormone-replacement therapy (HRT)	2.4	3.0	7.2	-0.9	-0.5	-0.0	-1.8	-2.1	-2.3	-2.7
Eye problems/disorders: Diabetes related eye disease	2.4	2.6	6.0	-2.4	-1.7	-1.2	-2.1	-1.9	0.1	-0.2
Angina (self-reported)	2.4	3.1	4.9	-1.8	-2.2	-2.1	-2.2	-1.7	-1.2	-0.6
Pain experienced in last month	2.4	4.0	9.2	3.0	2.8	1.9	1.7	2.0	0.4	0.5
Basal cell carcinoma (self-reported)	2.4	2.8	10.3	1.7	1.5	3.2	0.9	1.4	-1.3	-0.5
Primary Biliary Cirrhosis	2.3	3.2	8.6	2.2	2.2	1.4	1.3	2.9	-0.1	1.0
Wheeze or whistling in the chest in last year	2.3	4.2	8.4	-2.0	-2.2	-2.9	-1.5	-0.2	2.1	2.2
Mouth/teeth dental problems: Loose teeth	2.3	2.7	5.6	-2.4	-2.2	-0.9	-2.1	-1.6	-0.5	0.2
Hearing difficulty/problems: Yes	2.2	3.3	10.3	-1.3	-2.0	-0.8	-1.7	-0.1	3.2	1.9
Angina	2.2	2.9	5.0	-1.7	-2.1	-1.9	-2.2	-1.6	-1.2	-0.5
Chest pain or discomfort	2.2	3.2	8.3	-2.3	-2.2	-2.9	-1.3	-1.1	-0.3	0.8
Maternal smoking around birth	2.1	3.1	9.4	-0.4	-1.1	0.6	0.4	-1.5	-3.1	-2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	10.0	-1.9	-1.8	-3.2	-1.4	-1.8	-0.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	9.1	-0.8	0.2	-0.3	0.1	0.6	3.0	3.0
Taking other prescription medications	2.0	3.0	4.9	-1.6	-1.9	-2.2	-1.8	-0.9	1.7	1.7
Neck or shoulder pain in last month	2.0	2.8	5.7	-2.4	-1.8	-2.1	-1.1	-1.7	-1.2	-1.0
Overall health rating	2.0	4.2	7.8	-2.8	-2.5	-1.9	-1.9	-1.1	1.7	2.0
Irritability	2.0	3.4	7.7	-2.8	-2.0	-2.3	-2.1	-0.5	0.3	1.4
Sensitivity / hurt feelings	1.9	3.2	8.2	-2.0	-2.9	-2.6	-1.3	-1.0	0.8	0.1
Had menopause	1.9	2.3	3.3	-1.1	-1.0	-1.8	-1.6	-1.8	-1.5	-1.6
Mouth/teeth dental problems	1.9	2.9	5.6	2.4	2.0	1.8	2.2	1.6	0.3	-0.0
Health satisfaction	1.9	2.4	4.3	-2.0	-1.9	-1.5	-1.3	-0.5	2.1	0.9
Diabetes diagnosed by doctor	1.9	3.1	5.6	-2.2	-2.4	-2.4	-1.8	-1.0	0.5	1.2
Pulse wave Arterial Stiffness index	1.8	2.1	3.8	-0.9	-1.9	-1.9	-1.2	-1.5	-1.3	-1.1
Blood clot in the leg (DVT)	1.8	2.3	7.9	-0.6	0.4	-0.3	0.3	0.6	2.8	2.7
Medication: Gliclazide	1.8	2.1	4.7	-1.8	-2.2	-1.0	-1.9	-0.8	0.4	1.1
Hearing aid user	1.7	1.9	3.1	-1.5	-0.5	-1.7	-1.3	0.0	1.7	1.8
Type 2 Diabetes (T2D) (2018)	1.6	3.0	6.4	-2.5	-2.0	-2.5	-1.6	-0.9	0.3	1.1
Diabetes (self-reported)	1.6	2.4	4.3	-1.9	-1.8	-2.1	-1.8	-0.7	0.5	1.3
Pulse wave peak to peak time	1.6	1.8	3.2	0.6	1.8	1.8	1.0	1.4	1.4	1.2
Vitamin and mineral supplements	1.5	2.0	6.3	-0.1	-0.1	-0.6	-0.8	-1.9	-1.8	-2.5
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	6.3	-1.2	-1.7	-1.0	-0.5	-0.0	2.1	2.5
Knee pain experienced in last month	1.5	2.4	6.2	-2.0	-1.5	-1.6	-0.8	-2.5	-0.3	-1.1
Medication: Lisinopril	1.5	2.0	5.2	0.7	2.3	1.9	1.3	1.6	-0.1	0.7
Medication: Atorvastatin	1.5	1.9	4.2	-2.1	-1.5	-1.1	-1.8	-1.3	-0.8	-0.3
Bipolar Disorder (2011)	1.4	1.3	6.0	-0.2	0.3	-0.8	-0.1	-0.8	-2.5	-1.4
Blood Platelet Count	1.4	16.6	37.8	2.1	2.8	3.2	2.5	4.9	6.2	5.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.2	-2.0	-1.5	-2.1	-1.1	-0.8	-0.1	0.1
Medication: Aspirin	1.4	1.8	6.0	-1.2	-1.6	-2.5	-1.1	-1.2	-0.4	0.1
Financial situation satisfaction	1.4	1.7	3.5	-1.9	-1.8	-0.8	-1.0	-1.6	0.7	-0.4
Depression (Nagel 2018)	1.3	1.9	4.1	-1.7	-1.1	-0.7	0.5	-0.4	2.0	2.0
Neuroticism	1.3	3.2	5.5	-1.7	-2.3	-2.0	-0.7	0.8	2.3	2.0
Serious illness, injury or assault to yourself	1.3	1.5	3.3	-1.8	-1.8	-1.0	-1.7	-0.6	0.2	-0.2
Glaucoma (self-reported)	1.3	1.5	3.6	-1.4	-1.1	-1.0	-0.8	-0.2	1.4	1.9
Migraine (self-reported)	1.3	1.6	3.3	-1.8	-1.0	-1.3	-1.1	-1.4	-0.5	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.1	-0.2	-0.1	0.4	-0.6	-1.7	-1.8	-2.0
Ever taken oral contraceptive pill	1.3	1.4	4.1	1.4	2.0	0.7	0.9	1.4	-0.2	-0.8
Medication: Paracetamol	1.3	2.0	5.3	-2.3	-1.1	-0.9	-1.4	-1.9	-0.8	-0.9
Illnesses of father: High blood pressure	1.3	1.7	5.7	-1.3	-2.4	-0.8	-0.1	-1.0	-1.5	-0.7
Alzheimer’s Disease (in mother)	1.2	1.4	3.0	-0.6	-0.2	-1.5	-0.3	-1.2	-1.7	-1.7
LDL Cholesterol	1.2	1.9	7.9	0.4	-0.3	0.1	0.3	-1.2	-2.8	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	5.5	-1.5	-1.1	-1.2	-1.5	-1.9	-2.3	-1.4
Hair/balding pattern: Pattern 3	1.2	1.8	3.6	1.9	1.6	0.9	1.4	1.8	-0.5	0.4
Medication: Lansoprazole	1.2	1.3	4.3	-0.5	-0.5	-0.5	-2.1	-1.7	-0.7	-0.9
Medication: Ibuprofen	1.2	1.5	3.1	-1.7	-0.5	-1.7	-1.5	-1.0	-0.7	-0.6
Medication: Aspirin	1.2	1.6	4.9	-1.3	-1.4	-2.2	-1.1	-1.1	-0.2	-0.1
Commuting to job workplace: Walk	1.2	1.2	4.4	-0.4	-0.8	-1.1	-0.3	0.8	2.1	1.3
Fractured/broken bones in last 5 years	1.2	1.6	3.4	-1.4	-1.9	-0.7	-1.3	-1.1	-0.2	-1.5
Ulcerative Colitis (UC)	1.1	2.1	5.1	-1.0	-0.9	-2.0	-1.0	0.8	1.6	2.3
Medication for hormone replacement therapy	1.1	1.3	2.1	1.3	1.3	0.9	1.0	1.5	1.0	0.5
Fed-up feelings	1.1	1.9	5.4	-0.8	0.5	-0.1	1.4	1.5	1.7	2.3
Neuroticism score	1.1	2.2	5.3	-1.3	-2.3	-1.7	-0.2	0.6	1.7	1.6
Medication: Paracetamol	1.1	1.9	4.2	-2.1	-1.6	-1.0	-1.3	-1.7	-0.8	-0.6
Headache pain in last month	1.1	1.9	6.9	-1.8	-2.6	-1.3	0.0	-0.4	0.9	0.7
Worry too long after embarrassment	1.1	1.8	4.5	-0.5	-1.8	-2.1	-1.0	0.6	1.5	1.2
Supplements: Vitamin C	1.1	1.3	4.5	-0.9	-0.2	-2.1	-0.6	0.3	0.7	1.7
Mood swings	1.1	2.0	4.9	-1.2	-1.4	-1.6	0.6	1.0	1.3	2.2
Schizophrenia (2018)	1.0	2.0	4.9	0.6	1.0	0.1	0.5	2.2	2.2	1.8
Hand grip strength (left)	1.0	2.7	6.6	1.5	2.6	0.4	1.8	2.3	-0.0	1.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.4	-1.5	-1.3	-0.2	-1.0	-1.5	-0.5	-0.6
Multivitamins +/- minerals	1.0	1.3	3.5	0.1	-0.2	0.9	1.3	1.4	1.2	1.9
Tense / ‘highly strung’	1.0	1.6	3.7	-0.6	-1.4	-0.5	0.6	1.4	1.8	1.9
Loneliness, isolation	1.0	1.3	2.9	0.9	1.3	1.0	1.7	1.4	0.6	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	3.1	-0.9	0.9	-0.7	-0.1	0.5	1.4	1.8
Guilty feelings	1.0	1.5	4.1	-1.3	-2.0	-1.4	-0.2	-1.0	1.2	0.5
Commuting to job workplace: Public transport	1.0	1.2	2.7	1.4	-0.9	-1.7	1.3	1.0	0.1	0.5
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.9	-0.3	-0.6	-0.3	-0.4	0.8	1.6	2.2
Hand grip strength (right)	0.9	2.5	4.9	1.2	2.2	0.7	1.8	2.0	0.8	1.6
Pain all over the body in last month	0.9	1.0	2.1	-1.2	-1.4	-0.7	-0.9	-1.4	-0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	3.1	1.4	0.5	-0.6	1.8	1.2	-1.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	7.3	-0.8	-1.7	-2.7	-1.1	-0.3	0.4	0.8
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.6	-1.9	-0.8	-0.9	-1.2	-0.6	0.4	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.9	0.9	-0.1	-0.6	0.4	-0.1	-1.5	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.9	-0.6	-1.6	-0.2	-1.7	-1.0	-0.8	-0.5
Number of full sisters	0.9	1.0	2.5	-1.6	-0.3	-0.8	-1.3	-1.2	-0.8	-0.3
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.5	0.3	1.9	1.5	1.0	0.1	-0.0	-0.1
Illnesses of father: Heart disease	0.9	1.3	5.5	0.5	-0.4	-0.9	1.2	0.0	-2.3	-0.9
Ever had bowel cancer screening	0.9	1.0	3.8	-0.4	0.4	-1.2	-2.0	0.4	0.6	1.1
Smoking status: Current	0.9	1.4	3.1	-1.8	-0.2	0.2	-1.4	-1.1	-1.6	-0.9
Wears glasses or contact lenses	0.9	1.0	4.2	-0.9	-0.5	-0.7	-2.0	-0.3	0.5	1.0
Ever smoked	0.9	1.7	4.1	-2.0	-0.8	-1.6	-1.5	-1.1	-0.7	-0.3
Frequency of depressed mood in last 2 weeks	0.8	1.2	3.5	-0.8	-0.3	-0.1	0.8	0.3	1.9	1.8
Medication: Co-codamol	0.8	0.9	2.7	-1.4	-0.5	-0.6	-1.6	-0.8	-0.2	-0.3
Stomach or abdominal pain in last month	0.8	1.0	2.1	-1.4	-1.4	0.1	-0.7	-0.2	0.4	1.5
Supplements: Glucosamine	0.8	1.0	2.3	0.0	1.1	0.2	-0.3	-0.9	-1.5	-1.5
High blood pressure (mother)	0.8	1.1	3.5	-1.9	-0.3	-0.5	0.5	-1.0	-1.0	-1.3
Had other major operations	0.8	0.9	1.8	1.1	0.4	0.9	1.4	0.7	-1.3	-0.5
Depression (self-reported)	0.8	0.9	2.5	-0.7	-1.6	-1.4	0.4	-1.1	0.1	-0.2
Medication: Amlodipine	0.8	1.2	3.1	-0.9	-1.0	-1.8	-0.7	-1.3	0.9	0.7
Exposure to tobacco smoke outside home	0.8	1.0	2.4	-1.1	-0.7	0.3	-1.5	-1.6	-0.7	-0.1
Eye problems/disorders: None of the above	0.8	0.9	2.8	1.7	0.6	0.5	0.8	0.9	-0.8	-0.7
Mean time to correctly identify matches	0.8	1.6	3.3	-0.3	-1.1	-0.8	-1.0	-1.6	-1.5	-1.8
Qualifications: nursing, teaching	0.8	1.3	3.0	1.7	1.4	-0.4	1.7	1.1	-0.3	-0.2
High cholesterol (Self-reported)	0.8	1.5	3.9	-2.0	-0.5	-1.5	-0.3	-1.7	-0.8	-0.6
Neuroticism (Nagel 2018)	0.7	1.6	4.0	-1.3	-2.0	-1.9	0.0	0.2	0.8	1.1
Waist Hip Ratio (WHR)	0.7	3.2	5.5	-2.1	-2.3	-2.0	-2.1	-1.6	0.3	1.0
Chronotype (morning person)	0.7	1.7	4.3	-1.0	-1.6	-2.1	-1.6	-1.0	-0.6	0.3
Average weekly spirits intake	0.7	0.9	1.4	-0.9	-0.4	-0.5	-1.1	-1.2	-1.1	-1.2
Systolic blood pressure, automated reading	0.7	2.2	7.7	0.9	0.8	1.1	0.2	-0.1	-2.8	-2.2
Age when periods started (menarche)	0.7	1.6	5.8	0.3	1.1	-0.3	-0.1	-0.6	-2.4	-1.9
Medication: Levothyroxine sodium	0.7	1.2	5.5	-0.4	-1.2	-2.3	-0.5	-0.9	-0.4	0.1
Chronic bronchitis/emphysema (father)	0.7	0.8	2.5	-0.2	1.6	0.8	-0.5	0.4	0.6	1.2
Illnesses of siblings	0.7	1.0	3.0	1.6	1.7	0.3	0.1	1.0	-0.0	-0.3
Mouth/teeth dental problems: Dentures	0.7	1.2	3.0	-0.8	-0.0	0.3	-1.7	-1.2	-1.2	-1.2
Loud music exposure frequency	0.7	0.8	2.8	-1.7	-0.7	-0.9	-0.7	-0.8	-0.3	0.3
Gout (self-reported)	0.7	1.0	2.7	1.4	-0.1	-0.9	0.6	1.7	0.7	0.9
Qualifications: College or University degree	0.7	2.3	6.7	-0.5	-0.3	-1.8	-0.1	0.4	2.3	2.6
Eye problems/disorders: Cataract	0.7	0.8	2.2	-0.2	-0.3	-0.9	0.6	0.3	1.4	1.5
Asthma (self-reported)	0.7	1.5	4.0	-0.9	-2.0	-1.2	-1.7	-0.4	1.0	0.3
Average weekly champagne plus white wine intake	0.7	0.9	3.6	0.6	0.2	-0.5	0.2	-0.2	1.9	1.4
Miserableness	0.7	1.2	2.7	-0.6	-1.6	-0.8	0.3	0.7	1.3	1.6
Unable to work because of sickness or disability	0.7	0.9	1.8	-0.8	-0.2	-0.1	-1.3	-0.7	-1.2	-1.4
Alcohol drinker status: Previous	0.7	0.8	3.1	-1.8	-0.7	-0.4	-1.3	0.1	0.0	-0.1
Alzheimer’s Disease (including proxy)	0.6	0.8	4.2	-0.8	-0.6	-2.1	-0.4	-0.6	0.0	-0.2
Coronary Artery Disease (CAD)	0.6	0.7	1.7	1.0	0.5	0.8	0.5	1.3	-0.7	0.7
Heel T-Score	0.6	5.1	17.6	-1.8	-1.0	-1.7	-1.1	-2.0	-4.2	-2.4
Hypothyroidism (self reported)	0.6	1.3	5.1	-0.5	-1.7	-2.3	-0.1	-0.5	-0.9	-0.3
Impedance of leg (right)	0.6	3.0	8.3	-2.4	-2.2	-0.6	-2.9	-1.2	0.7	-0.0
Townsend deprivation index at recruitment	0.6	0.9	2.4	-1.1	-1.5	-0.4	-0.8	-1.1	0.7	0.2
Current tobacco smoking	0.6	0.9	2.4	-1.4	0.1	0.4	-1.0	-0.8	-1.6	-0.7
Hair/balding pattern: Pattern 2	0.6	0.8	2.0	-1.3	-0.4	-1.4	-0.5	-0.9	-0.3	-0.8
Qualifications: None of the above	0.6	1.2	2.7	-1.4	-1.7	0.8	-0.8	-1.6	-0.0	0.2
Hip circumference	0.6	2.7	7.5	1.3	0.5	-0.2	2.7	1.2	2.1	2.0
Time employed in main current job	0.6	0.7	2.1	-1.1	-0.7	-0.9	-1.4	-0.3	-0.6	0.1
Happiness	0.6	0.7	3.7	-0.0	-0.0	0.2	0.5	0.3	1.9	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.7	-1.3	-0.4	-1.1	-1.1	-0.9	-0.5	-0.3
Number of children fathered	0.6	0.7	2.2	0.8	1.5	-0.2	0.7	0.5	-1.0	0.0
Had major operations	0.6	0.7	1.6	0.2	0.9	0.3	1.3	0.8	0.6	1.2
Friendships satisfaction	0.6	0.7	2.6	-0.6	-0.9	-0.8	-0.1	-0.8	1.6	0.4
Mineral and other dietary supplements	0.6	0.9	2.3	1.0	0.5	0.4	1.1	0.3	-1.0	-1.5
Alcohol drinker status: Never	0.6	0.7	1.4	-0.5	-1.2	0.2	-0.7	-1.1	-1.1	-0.6
Schizophrenia vs Biploar Disorder	0.5	0.6	1.7	1.0	0.3	-0.3	0.4	0.9	1.3	0.8
Crohns Disease (2017)	0.5	1.0	2.8	0.8	1.2	0.4	1.7	1.0	0.6	0.7
Irritable Bowel Disease (IBD)	0.5	1.1	3.4	-0.3	0.1	-1.3	0.3	0.9	1.3	1.8
Triglycerides	0.5	0.7	2.1	0.4	0.9	1.4	-0.6	0.3	-0.9	-1.0
Ever had hysterectomy (womb removed)	0.5	0.5	1.4	-0.3	0.2	0.6	0.0	-1.2	-1.0	-0.8
Diabetes (mother)	0.5	0.7	1.4	-0.8	-0.1	0.4	-1.2	-0.9	-1.1	-0.7
Pack years adult smoking proportion	0.5	0.8	1.9	0.4	1.4	0.7	0.9	0.5	0.8	1.1
High blood pressure	0.5	1.3	4.2	-0.5	0.1	-2.1	0.2	-1.0	-1.6	-0.9
Past tobacco smoking	0.5	1.0	2.1	1.4	1.2	1.3	1.0	0.6	0.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.8	-0.7	-0.1	-0.7	-1.2	-0.7	-1.9	-0.7
Worrier / anxious feelings	0.5	1.0	2.5	-0.5	-1.6	-1.6	-0.7	-0.6	-0.6	-0.7
Pulse rate	0.5	0.8	1.9	-0.1	0.9	-0.2	0.7	-1.0	-1.2	-1.4
Medication: Cholesterol lowering	0.5	0.7	2.0	-0.9	-0.8	-1.4	-1.0	-0.7	-0.3	-0.0
Pulse wave reflection index	0.5	0.6	2.7	-0.2	-1.6	-0.7	-0.9	-0.5	-0.3	-0.4
Forced vital capacity (FVC), Best measure	0.5	2.0	6.2	-0.6	-0.3	-0.2	1.1	1.5	2.5	1.9
Age at first live birth	0.5	1.0	1.9	0.6	1.0	-0.2	1.1	1.4	0.8	1.3
Shortness of breath walking on level ground	0.5	0.6	1.6	0.4	-1.2	-0.7	1.0	0.5	0.7	0.3
Emphysema/chronic bronchitis	0.5	0.6	1.2	-1.1	-1.1	-0.1	-0.8	-0.1	0.9	-0.5
Medication: Allopurinol	0.5	0.6	1.1	0.7	-0.8	-0.7	0.7	0.8	0.6	1.0
Heart disease (mother)	0.5	0.7	1.9	-0.4	-1.4	0.6	-0.4	-1.2	-0.3	-0.6
Hypertension (Self-reported)	0.5	1.4	3.7	-0.4	0.1	-1.6	0.3	-1.3	-1.9	-1.2
Leg fat-free mass (right)	0.5	2.6	8.9	1.3	0.5	-0.9	3.0	1.8	1.3	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	-0.9	-0.4	-0.8	-0.5	-0.8	-1.2	-0.5
Leg predicted mass (right)	0.5	2.6	8.6	1.4	0.5	-0.9	2.9	1.7	1.2	1.4
Mother’s age at death	0.5	0.6	2.1	-0.2	-0.9	-1.5	-0.3	-0.8	-0.5	-0.8
Eye problems/disorders: Glaucoma	0.5	0.5	1.9	-0.8	0.4	-0.4	-0.4	0.3	0.8	1.4
Diastolic blood pressure, automated reading	0.5	1.6	4.6	1.3	1.0	-0.5	1.4	1.3	-2.1	-0.6
Supplements: Calcium	0.5	0.5	2.2	-0.5	0.1	1.5	-0.2	0.4	0.7	0.7
Bipolar Disorder or Schizophrenia	0.4	0.9	2.6	0.4	0.8	0.5	0.4	1.6	1.0	1.2
Depressed Affect (Nagel 2018)	0.4	0.9	2.3	-0.8	-0.8	-0.8	0.7	1.0	0.8	1.5
Major Depression (MDD)	0.4	0.5	2.3	0.1	-0.1	-0.4	-0.0	0.5	0.9	1.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.5	1.6	1.1	-0.2	1.4	0.7	0.9	0.5
Breast Cancer	0.4	0.9	1.7	-1.0	-1.3	-1.1	-0.9	-0.5	-0.9	-0.7
Prostate Cancer	0.4	0.6	0.9	-1.0	-0.8	-0.7	0.8	-0.5	-0.9	-0.5
Age at First Birth	0.4	0.6	2.3	1.5	-0.3	-0.6	1.2	0.4	-0.4	-0.0
Mean Putamen Volume	0.4	0.5	1.3	0.4	0.8	1.1	0.4	1.1	0.0	0.1
HDL Cholesterol	0.4	0.6	2.4	-0.3	-0.4	-0.5	-0.3	0.0	1.0	1.5
Lupus	0.4	0.6	1.1	1.0	0.4	-0.5	0.1	0.8	0.8	1.1
Schizophrenia (2014)	0.4	0.9	2.4	0.4	0.2	-0.2	0.5	1.5	1.6	1.0
Ulcerative Colitis	0.4	0.6	1.5	-0.7	-0.4	-1.2	-0.5	0.3	0.7	1.1
Blood White Count	0.4	2.8	9.7	1.1	3.1	1.7	1.1	1.5	1.2	1.0
Height	0.4	7.9	21.1	-2.8	-3.4	-4.6	-1.7	-0.9	2.8	1.7
Systolic Blood Pressure	0.4	2.0	4.9	1.5	1.8	2.2	0.8	0.6	-1.2	-1.2
Relative age of first facial hair	0.4	0.7	3.1	-0.1	-0.9	0.4	-0.2	-0.8	1.8	0.7
Leg fat-free mass (left)	0.4	2.2	5.8	1.0	0.5	-1.2	2.4	1.7	1.4	1.6
Impedance of leg (left)	0.4	2.0	5.2	-1.8	-2.3	-0.1	-2.0	-1.1	0.4	-0.5
Leg predicted mass (left)	0.4	2.3	6.4	1.1	0.5	-1.1	2.5	1.7	1.4	1.6
Allergy	0.4	0.9	2.7	0.4	1.4	0.4	0.7	-0.1	-1.6	-0.8
Fluid intelligence score	0.4	0.8	1.6	0.6	0.7	-0.8	1.2	-0.0	1.2	1.0
Arm fat percentage (right)	0.4	1.8	5.8	1.9	1.0	0.6	2.4	0.8	0.1	1.0
Trunk fat-free mass	0.4	2.1	3.8	-0.1	0.5	-1.9	1.1	1.5	1.9	1.8
Asthma	0.4	0.8	2.9	-0.3	-1.7	-0.7	-1.1	-0.2	0.7	-0.0
Trunk predicted mass	0.4	2.0	3.7	-0.0	0.6	-1.8	1.1	1.5	1.9	1.8
Standing height	0.4	4.2	12.5	-1.3	-1.7	-2.3	-0.1	1.3	3.5	2.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.4	0.7	0.4	1.5	0.5	0.6	0.1	-0.6
High blood pressure (siblings)	0.4	0.6	1.1	-0.5	-1.0	0.5	1.1	-0.6	-0.9	-0.4
Comparative body size at age 10	0.4	1.2	2.5	1.1	0.0	0.4	1.3	1.6	1.2	1.2
Number of full brothers	0.4	0.5	1.9	-0.2	-1.4	0.6	-0.1	0.1	0.2	1.1
Pulse rate, automated reading	0.4	1.2	2.6	-1.4	-0.2	-1.6	-1.2	-1.2	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.0	-0.2	-0.6	-0.8	1.0	1.0	1.7	0.6
Whole body fat-free mass	0.4	2.0	3.3	0.5	0.4	-1.7	1.8	1.5	1.6	1.6
Arm fat percentage (left)	0.4	1.7	5.7	1.8	0.8	0.6	2.4	0.8	0.2	1.1
Medication for cholesterol	0.4	0.7	1.8	-0.5	-0.2	1.4	-0.9	-0.3	-0.9	-0.9
Back pain experienced in last month	0.4	0.6	1.1	-1.0	-0.3	-0.0	-1.1	0.3	1.0	0.7
Whole body water mass	0.4	2.2	3.4	0.5	0.5	-1.6	1.9	1.7	1.7	1.7
Arm fat mass (left)	0.4	1.5	5.4	1.6	0.9	-0.0	2.3	0.9	0.3	1.1
Basal metabolic rate	0.4	2.1	4.1	0.6	0.5	-1.5	2.0	1.6	1.5	1.7
Number of operations (self-reported)	0.4	0.6	1.8	-1.0	-0.7	-0.7	-0.4	-0.6	-1.3	-0.4
Age started oral contraceptive pill	0.4	0.5	1.1	-0.8	-0.2	-1.0	-1.1	-0.5	-0.1	-0.6
Myopia	0.4	0.6	2.6	0.2	0.4	-0.4	0.7	0.1	1.6	0.7
Vascular/heart problems diagnosed by doctor	0.4	1.0	4.2	0.6	0.3	2.0	-0.2	0.8	1.2	0.5
Pack years of smoking	0.4	0.6	2.1	0.3	1.4	0.6	0.3	0.3	0.7	1.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.7	0.2	-0.3	-1.9	1.0	0.2	1.2	0.8
Worry (Nagel 2018)	0.3	0.6	2.4	0.1	-1.6	-0.5	0.4	1.0	0.4	0.4
Neuroticism (2016)	0.3	0.4	1.7	-0.4	0.0	1.3	0.8	-0.2	-0.5	-0.2
Blood Eosinophil Count	0.3	2.0	5.2	-1.1	-1.1	-2.3	-1.0	0.0	1.0	2.1
Blood Red Count	0.3	3.2	6.9	2.2	2.5	0.9	2.6	1.9	0.3	-0.0
BMI	0.3	1.7	6.0	1.5	1.0	-0.9	2.5	0.8	-0.8	0.4
Respiratory disease	0.3	0.7	2.0	-0.7	-1.4	-0.6	-0.9	0.4	0.9	-0.2
Relative age voice broke	0.3	0.4	1.3	1.0	-0.5	1.2	0.3	-0.3	0.4	0.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.9	-0.4	-1.4	-0.3	-0.7	-0.3	1.1	0.2
Medication: Atenolol	0.3	0.3	1.0	0.5	-0.2	-1.0	0.6	0.3	0.7	0.3
Sitting height	0.3	1.9	3.8	-1.1	-0.7	-2.0	0.3	1.5	1.7	1.6
Body mass index (BMI)	0.3	1.4	5.5	1.3	1.1	-0.3	2.3	0.7	-0.6	0.6
Alcohol usually taken with meals	0.3	0.5	1.3	-0.3	-0.5	-0.7	-1.0	-0.7	1.2	0.3
Forced vital capacity (FVC)	0.3	1.2	2.8	-1.2	-0.1	-0.9	0.3	1.1	1.7	1.4
Heart attack	0.3	0.4	0.7	0.9	-0.2	0.5	-0.5	0.8	-0.7	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	1.7	0.1	-0.6	-0.0	-1.0	0.2	1.3	-0.0
Medication: Simvastatin	0.3	0.5	0.9	0.6	1.0	-0.2	0.9	-0.3	-0.9	-0.5
Weight	0.3	1.6	4.2	0.6	0.2	-1.3	2.1	1.2	1.0	1.6
Father’s age at death	0.3	0.4	1.8	1.3	0.6	-0.3	-0.2	0.6	0.4	-0.5
Noisy workplace	0.3	0.3	1.4	-0.4	-0.6	-0.3	-1.2	-0.5	0.2	0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.7	1.3	0.2	-1.3	0.9	0.3	0.5	0.3
Lung cancer (father)	0.3	0.4	1.2	-0.4	0.2	-0.5	-1.1	0.3	0.7	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.4	-0.8	0.2	-0.2	0.9	0.9	1.6	1.0
Arm fat mass (right)	0.3	1.4	4.4	1.4	1.0	-0.3	2.1	0.9	0.2	1.2
Breastfed as a baby	0.3	0.3	1.3	0.2	-0.2	-1.1	-0.2	-0.2	0.9	0.1
Hair/balding pattern: Pattern 4	0.3	0.7	1.3	0.1	-1.1	-0.5	-0.9	-0.6	0.8	1.1
Arm fat-free mass (right)	0.3	1.5	4.7	-0.1	-0.2	-2.2	1.2	1.2	1.1	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.7	0.0	0.2	-0.1	0.3	0.2	-0.8	-1.3
Leg fat mass (right)	0.3	1.1	3.2	1.0	0.5	-0.7	1.8	1.1	0.4	1.1
Arm predicted mass (right)	0.3	1.7	4.3	0.0	-0.1	-2.1	1.5	1.4	1.2	1.4
Alcohol intake frequency.	0.3	0.8	1.6	-1.3	-0.8	0.2	-1.1	-0.1	0.5	1.2
Suffer from ‘nerves’	0.3	0.5	2.1	-0.4	-1.5	-0.7	0.2	-0.2	0.3	0.6
Age at last live birth	0.3	0.5	1.2	0.1	0.7	-0.4	0.9	0.8	0.1	1.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	1.2	0.7	0.5	0.4	0.4	-0.0	-0.6
Illnesses of father: None of the above (group 1)	0.3	0.4	1.7	0.0	0.4	-0.3	-1.3	-0.7	0.5	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	-0.7	-0.4	0.9	-0.7	-0.8	0.3	-0.0
Arm fat-free mass (left)	0.3	1.3	3.6	0.2	0.4	-1.9	1.4	1.2	0.7	1.0
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.2	0.4	0.2	0.7	0.0	0.6	0.4	1.1
Cholesterol lowering medication	0.3	0.4	1.0	-0.5	-0.5	-1.0	0.8	-0.4	0.1	0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.5	0.7	-0.3	0.4	-0.5	0.7	-0.7	-0.7
Impedance of whole body	0.3	1.5	4.2	-1.1	-2.0	0.7	-1.6	-1.1	0.7	-0.4
Leg fat mass (left)	0.3	1.1	4.0	1.1	0.4	-0.6	2.0	1.0	0.3	1.0
Arm predicted mass (left)	0.3	1.7	3.7	0.6	0.8	-1.7	1.9	1.6	0.8	1.2
Reaction Time	0.2	0.4	1.5	-0.4	-0.2	0.0	-0.0	-0.6	-0.7	-1.2
Crohns Disease (2012)	0.2	0.4	1.6	0.5	0.8	0.5	1.3	-0.1	0.3	-0.1
HbA1C	0.2	0.3	0.8	0.2	0.3	0.3	0.0	0.0	0.9	0.9
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.6	0.5	-0.3	-0.1	-0.6	-0.3	0.8
Smoking Status	0.2	0.4	1.3	-1.1	-0.1	-0.8	-0.7	-0.2	-0.7	-0.3
Allergy or Eczema	0.2	0.5	1.8	-0.4	-1.0	0.2	-0.2	0.2	1.3	0.4
Cardiovascular Disease	0.2	0.7	1.6	-0.4	-0.1	-1.3	0.8	-0.8	-1.1	-0.8
Lung FEV1/FVC ratio	0.2	1.0	2.0	-1.1	1.0	0.6	-0.5	-1.1	-0.7	-1.4
Lung FVC	0.2	1.0	3.0	-1.7	-0.7	-1.0	-1.0	-1.0	0.5	0.3
Trunk fat percentage	0.2	0.8	3.1	1.3	-0.1	-0.1	1.7	0.3	-0.1	0.7
Average weekly fortified wine intake	0.2	0.3	1.0	1.0	0.6	-0.3	0.6	-0.1	0.1	-0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.5	0.4	0.4	0.5	0.6	0.6	-0.3
Trunk fat mass	0.2	1.1	3.5	1.1	0.1	-0.6	1.9	0.7	0.5	1.2
Waist circumference	0.2	0.7	1.6	-0.0	-0.6	-1.3	1.0	-0.2	0.7	1.2
Number of incorrect matches in round	0.2	0.4	1.4	0.5	0.2	-0.3	0.1	1.2	0.1	0.9
Nervous feelings	0.2	0.4	1.7	-0.4	-1.3	-0.3	-0.6	0.2	-0.0	-0.6
Financial difficulties in last 2 years	0.2	0.2	0.9	-0.5	-0.2	0.1	0.1	-0.5	0.5	1.0
Impedance of arm (right)	0.2	0.9	2.6	-0.2	-0.9	1.4	-0.5	-0.3	1.6	0.4
Prospective memory result	0.2	0.2	0.7	0.4	-0.0	-0.1	-0.1	-0.2	-0.8	-0.7
Impedance of arm (left)	0.2	1.1	2.7	-0.5	-1.6	1.2	-1.0	-0.8	1.3	0.1
Length of working week for main job	0.2	0.2	0.5	-0.3	0.3	0.3	-0.5	-0.2	-0.3	0.7
Exposure to tobacco smoke at home	0.2	0.2	0.8	-0.2	0.1	-0.7	0.5	-0.9	0.1	-0.3
Birth weight of first child	0.2	0.4	1.1	-1.0	-0.1	-1.0	-0.1	-0.2	0.5	0.7
Peak expiratory flow (PEF)	0.2	0.4	1.2	-0.8	1.1	0.1	0.7	0.5	-0.6	-0.3
Birth weight	0.2	0.5	1.4	-0.9	0.1	-1.2	0.5	0.7	0.4	0.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.4	-0.2	0.3	0.8	-0.5	-0.4	-0.4
Body fat percentage	0.2	0.8	3.3	1.3	0.1	-0.1	1.8	0.4	-0.2	0.6
Medication: Omeprazole	0.2	0.3	0.8	-0.1	-0.9	0.8	-0.3	0.1	-0.6	-0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.6	-0.2	-0.3	0.8	-0.7	0.4	-0.2	-0.6
Whole body fat mass	0.2	1.0	3.8	1.2	0.4	-0.5	2.0	0.8	0.2	0.9
Comparative height size at age 10	0.2	1.4	3.3	-1.5	-0.9	-0.9	-0.8	-0.0	1.8	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	-0.0	-0.4	0.7	-0.9	0.0	-0.6	-0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.4	-0.6	-0.6	-0.4	-0.6	-0.4	0.2	0.3
Smoking status: Previous	0.2	0.2	0.8	0.1	-0.7	-0.9	0.0	0.2	0.4	0.2
Average weekly red wine intake	0.2	0.3	1.1	-0.1	-0.6	-1.0	-0.6	0.1	-0.1	-0.3
Breast cancer (self-reported)	0.2	0.3	0.9	-0.1	-1.0	-0.0	-0.4	-0.1	-0.5	-0.8
Medication: Blood pressure	0.2	0.5	1.0	0.4	0.2	-0.8	0.6	-0.6	-0.8	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.7	-0.2	-0.8	0.4	-0.6	0.2	-0.3	0.3
Bipolar Disorder (2018)	0.1	0.2	1.2	-0.1	0.0	0.5	0.0	-0.2	-1.1	-0.3
Ovarian Cancer	0.1	0.2	0.4	0.6	-0.4	0.4	0.6	0.2	0.4	-0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.1	0.3	0.3	0.3	0.5	0.6	0.3
Fasting Glucose	0.1	0.1	0.4	0.2	0.3	0.1	-0.6	0.1	0.3	-0.2
Hair Pigment	0.1	2.2	9.4	-1.7	-0.9	-0.7	-0.1	-3.1	-0.8	-1.0
Supplements: Zinc	0.1	0.1	0.4	-0.3	0.6	0.1	-0.1	0.4	0.1	0.3
Diabetes (father)	0.1	0.2	0.5	0.2	-0.2	0.7	0.2	-0.4	0.5	-0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.7	-0.8	-0.1	0.0	-0.6	-0.2	0.1	0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.1	-0.1	0.5	-0.1	-0.6	-0.6	-0.6
Number of live births	0.1	0.2	0.6	0.3	0.5	0.3	-0.6	0.0	0.0	0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	2.1	-1.4	0.4	-0.5	0.3	0.4	0.6	0.4
Leg fat percentage (right)	0.1	0.4	0.7	0.6	0.2	-0.7	0.8	0.3	-0.1	0.8
Medication: Blood pressure	0.1	0.2	0.8	-0.3	-0.3	-0.9	-0.0	-0.4	-0.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	0.1	-0.4	-0.3	-0.1	-0.1	-0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	-0.5	-0.1	0.3	-0.5	0.0	0.4	0.1
Medication: Bendroflumethiazide	0.1	0.1	0.5	-0.2	0.1	-0.1	0.3	-0.5	-0.1	0.7
Leg fat percentage (left)	0.1	0.5	1.9	0.9	0.0	-0.5	1.4	0.3	-0.2	0.6
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.1	-0.5	0.0	0.3	-0.1	-0.5	0.7
Ever depressed for a whole week	0.1	0.2	0.6	-0.2	-0.7	-0.7	-0.1	0.0	-0.2	0.3
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.3	0.5	0.5	-0.1	0.3	-0.0	0.2
Heart disease (siblings)	0.1	0.1	0.3	0.1	-0.4	0.3	0.6	-0.2	0.1	0.2
Tanning	0.0	0.5	1.3	-1.1	-0.7	-1.0	-0.5	-0.1	0.2	0.7

Hub : Genes

PHLPP1

Models

Trait associations