Hub : Genes

PIGS

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1080 0.0310 2.2e-09 0.110 0.077 0.094 0.088 0.094 2.9e-13 1.2e-09 1.7e-11 8.3e-11 1.6e-11
2 NTR Blood 0.0249 0.0097 1.1e-04 0.005 0.009 0.004 0.009 0.002 6.2e-03 3.4e-04 1.8e-02 4.7e-04 5.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.8 1.2 2.3 -1.5 0.3
Bipolar Disorder or Schizophrenia 0.0 0.1 0.1 0.4 0.1
Depressed Affect (Nagel 2018) 1.0 2.1 3.9 -2.0 -0.6
Depression (Nagel 2018) 1.6 2.4 4.8 -2.2 -0.2
Intelligence (Savage-Jansen 2018) 1.0 3.1 5.2 2.3 -1.1
Neuroticism (Nagel 2018) 1.8 4.3 8.6 -2.9 -0.0
Schizophrenia (2018) 0.7 1.5 2.9 1.7 -0.0
Schizophrenia vs Biploar Disorder 1.2 1.5 2.7 1.6 -0.6
Worry (Nagel 2018) 1.6 3.3 6.2 -2.5 -0.6
Alzheimer’s Disease (in mother) 2.8 3.3 6.4 0.3 2.5
Alzheimer’s Disease (in father) 0.6 0.7 1.3 0.3 -1.1
Alzheimer’s Disease (including proxy) 0.7 1.1 1.6 0.8 1.3
Crohns Disease (2017) 0.7 1.6 1.9 -1.1 -1.4
Irritable Bowel Disease (IBD) 1.4 3.4 4.4 -2.1 -1.5
Ulcerative Colitis (UC) 0.9 1.7 3.0 -1.7 -0.6
Major Depression (MDD) 1.4 1.7 2.0 -1.4 -1.2
Reaction Time 3.4 6.4 12.5 3.5 0.6
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.4 1.6 0.4
Breast Cancer 1.3 3.0 5.0 -1.0 -2.2
Ovarian Cancer 2.4 3.2 5.2 -1.1 -2.3
Prostate Cancer 0.1 0.1 0.1 0.3 0.3
Age at First Birth 0.6 0.9 1.6 0.5 1.3
Bipolar Disorder (2011) 3.0 2.9 4.8 -1.0 -2.2
Body Mass Index (BMI) (2010) 0.9 1.2 1.9 1.4 -0.7
Coronary Artery Disease (CAD) 0.3 0.3 0.5 -0.4 -0.7
Crohns Disease (2012) 1.0 1.6 1.8 -1.1 -1.4
Mean Putamen Volume 6.0 6.8 11.6 -3.4 -1.4
Fasting Glucose 0.5 0.6 1.1 0.2 -1.1
HbA1C 2.9 3.2 4.4 -2.1 -1.4
HDL Cholesterol 0.3 0.6 0.6 -0.8 -0.7
LDL Cholesterol 5.0 7.9 9.6 -2.5 -3.1
Lupus 1.4 2.0 3.4 1.8 0.8
Neuroticism (2016) 1.8 2.7 4.6 -2.1 -0.8
Primary Biliary Cirrhosis 0.2 0.3 0.6 0.7 0.2
Rheumatoid Arthritis 0.6 0.8 1.5 1.2 0.4
Schizophrenia (2014) 0.1 0.2 0.4 0.0 0.6
Triglycerides 0.9 1.4 2.5 -0.6 1.6
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 0.4 -0.2
Ulcerative Colitis 1.2 1.7 2.8 -1.7 -0.8
Blood Eosinophil Count 0.0 0.3 0.5 0.0 0.7
Blood Platelet Count 2.2 25.2 43.0 2.7 -6.6
Blood Red Count 6.9 66.6 99.4 -5.8 -10.0
Blood White Count 1.8 13.4 20.1 2.6 4.5
Heel T-Score 1.2 9.9 13.2 -2.6 3.6
BMI 1.3 7.7 14.1 -1.2 -3.8
Height 0.4 7.0 8.0 -2.5 -2.8
Waist Hip Ratio (WHR) 0.8 3.5 5.3 2.3 -1.3
Systolic Blood Pressure 1.3 6.6 8.0 2.8 2.3
Smoking Status 0.8 1.9 2.5 -1.1 -1.6
Allergy or Eczema 0.9 2.3 4.6 0.2 -2.1
Cardiovascular Disease 0.4 1.5 1.9 1.0 -1.4
Hypothyroidism (self reported) 1.1 2.5 4.4 -0.8 2.1
Respiratory disease 1.3 2.9 5.7 -0.4 2.4
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.1 1.0 -0.3
Lung FEV1/FVC ratio 0.3 1.3 2.2 1.5 -0.5
Lung FVC 0.0 0.1 0.2 -0.4 -0.1
Neuroticism 2.0 4.7 5.4 -2.3 -2.0
Chronotype (morning person) 0.8 1.8 1.9 -1.3 -1.4
Hair Pigment 0.0 1.1 1.6 1.3 -0.8
Tanning 0.0 0.2 0.3 -0.6 0.1
Hand grip strength (left) 1.4 3.6 4.8 -2.2 -1.6
Number of treatments/medications taken 0.2 0.4 0.8 0.3 -0.9
Average weekly spirits intake 0.4 0.5 1.0 -1.0 0.1
Sensitivity / hurt feelings 2.0 3.4 6.8 -2.6 -0.3
Frequency of depressed mood in last 2 weeks 2.2 3.1 5.2 -2.3 -0.9
Hearing difficulty/problems: Yes 3.3 5.1 6.8 1.8 2.6
Relative age of first facial hair 2.5 5.2 7.3 -1.7 -2.7
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 1.9 -1.4 0.3
Ever used hormone-replacement therapy (HRT) 3.6 4.6 9.2 -0.2 3.0
Ever had hysterectomy (womb removed) 2.1 2.4 4.7 0.1 2.2
Systolic blood pressure, automated reading 1.2 3.4 5.1 2.3 1.3
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 1.2 -1.0 1.1
Angina 2.3 3.0 3.6 -1.5 -1.9
Medication for hormone replacement therapy 4.1 4.6 5.0 -2.0 2.2
Vitamin and mineral supplements 0.2 0.2 0.4 0.1 0.7
Supplements: Zinc 2.2 2.4 3.8 -1.0 -1.9
Medication: Co-codamol 0.9 1.0 1.9 -0.4 -1.4
Medication: Metformin 0.6 0.8 1.3 1.1 0.6
Diabetes (father) 0.5 0.6 0.6 -0.8 0.8
Diabetes (mother) 0.1 0.2 0.2 -0.4 -0.4
Severe depression (siblings) 1.0 1.1 2.1 0.3 -1.4
Pack years adult smoking proportion 0.0 0.0 0.0 -0.2 0.1
Impedance of leg (right) 0.2 0.7 1.0 0.7 1.0
Leg fat-free mass (left) 1.0 5.4 9.9 -0.9 -3.1
Trunk fat percentage 0.6 2.3 3.7 1.0 -1.9
Hand grip strength (right) 1.7 4.6 5.2 -2.0 -2.3
Townsend deprivation index at recruitment 1.0 1.5 2.4 1.6 -0.7
Current tobacco smoking 0.3 0.6 0.9 -0.5 -0.9
Average weekly fortified wine intake 0.1 0.2 0.3 -0.2 0.5
Maternal smoking around birth 0.3 0.5 0.6 -0.6 -0.8
Fed-up feelings 0.1 0.2 0.2 -0.3 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 1.9 -1.4 -0.4
Relative age voice broke 0.8 1.2 2.0 -1.4 -0.6
Taking other prescription medications 0.5 0.7 1.4 -0.0 1.2
Age when periods started (menarche) 0.0 0.1 0.1 0.3 -0.2
Bilateral oophorectomy (both ovaries removed) 2.3 2.7 5.1 -0.6 2.2
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 5.6 0.1 2.4
Tinnitus: Yes, but not now, but have in the past 4.6 4.9 5.9 -2.4 -2.0
Qualifications: CSEs or equivalent 1.1 1.4 2.4 -0.7 -1.6
Serious illness, injury or assault to yourself 2.0 2.5 4.9 -2.2 0.2
High blood pressure 0.4 1.1 2.2 1.5 0.1
Hayfever, allergic rhinitis or eczema 1.0 2.2 3.8 0.7 -2.0
Multivitamins +/- minerals 0.3 0.3 0.5 0.4 0.7
Stomach or abdominal pain in last month 0.2 0.2 0.4 -0.7 -0.1
Supplements: Glucosamine 0.0 0.1 0.1 -0.3 0.1
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 1.7 -1.3 0.8
Medication: Atenolol 1.1 1.4 2.8 -0.3 -1.7
Medication: Levothyroxine sodium 0.9 1.5 2.3 0.8 1.5
Sitting height 0.1 0.4 0.6 -0.4 0.8
Chronic bronchitis/emphysema (father) 2.3 2.7 2.9 1.7 -1.6
High blood pressure (mother) 0.6 0.8 1.2 0.7 -1.1
Body mass index (BMI) 1.0 4.1 7.4 -0.9 -2.7
Impedance of leg (left) 0.2 1.0 1.3 0.9 1.2
Leg predicted mass (left) 1.0 5.6 10.2 -0.9 -3.2
Trunk fat mass 0.8 3.3 6.5 0.4 -2.5
Waist circumference 1.9 6.8 13.2 0.6 -3.6
Number of incorrect matches in round 1.0 1.7 3.4 -0.1 -1.9
Past tobacco smoking 0.7 1.4 2.3 0.7 1.5
Alcohol usually taken with meals 0.8 1.4 2.3 -1.5 -0.6
Nervous feelings 0.5 0.9 1.8 -0.1 -1.4
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.4 3.2 -1.3 -1.8
Hearing difficulty/problems with background noise 0.5 0.7 1.3 1.2 -0.3
Hair/balding pattern: Pattern 2 1.4 1.8 2.3 -1.5 1.1
Had menopause 0.2 0.3 0.4 -0.6 0.5
Had other major operations 0.1 0.2 0.3 -0.5 0.3
Forced vital capacity (FVC) 0.1 0.3 0.6 -0.1 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 5.8 -0.1 2.4
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 2.5 -0.1 -1.6
Qualifications: None of the above 0.0 0.1 0.1 0.3 0.0
Financial difficulties in last 2 years 0.1 0.2 0.2 -0.5 -0.3
Mouth/teeth dental problems 1.6 2.5 3.6 1.1 1.9
Heart attack 1.9 2.4 3.3 -1.8 -1.2
Allergy 0.4 0.8 0.8 -0.9 0.9
Pain all over the body in last month 0.5 0.6 1.0 -0.3 1.0
Diabetes (self-reported) 0.5 0.7 1.3 0.3 1.1
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.5 1.2 0.4
Medication: Ramipril 2.6 3.3 6.1 2.5 0.7
Medication: Simvastatin 2.3 3.4 3.5 -1.8 -1.9
Fluid intelligence score 0.1 0.2 0.3 -0.3 0.6
Illnesses of siblings 0.1 0.2 0.4 0.6 0.0
Neuroticism score 1.4 3.0 4.8 -1.1 -2.2
Weight 1.5 7.3 13.9 -0.9 -3.7
Impedance of arm (right) 2.4 11.2 15.2 3.9 2.7
Arm fat percentage (right) 0.8 3.0 4.9 1.0 -2.2
Trunk fat-free mass 1.7 9.5 14.7 -2.1 -3.8
Hip circumference 1.0 4.4 8.7 0.2 -3.0
Time employed in main current job 2.7 3.1 4.5 -2.1 -1.3
Alcohol intake versus 10 years previously 0.6 0.9 1.0 1.0 -0.9
Father’s age at death 0.8 1.0 1.8 0.4 1.4
Worrier / anxious feelings 2.4 4.6 6.2 -2.5 -1.7
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 0.2 -0.5
Falls in the last year 0.8 1.1 1.3 1.1 -0.9
Hair/balding pattern: Pattern 3 0.2 0.3 0.5 -0.5 -0.7
Number of live births 1.6 2.2 3.5 -0.9 1.9
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 0.9 0.2 -0.9
Pulse rate 0.8 1.3 2.2 0.7 1.5
Happiness 0.8 1.0 2.0 0.0 1.4
Noisy workplace 0.8 0.9 1.4 1.2 -0.7
Qualifications: A levels/AS levels or equivalent 1.3 2.8 5.6 0.0 -2.4
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 -0.1 -0.3
Mouth/teeth dental problems: Dentures 0.6 1.1 1.1 1.0 1.0
Asthma 1.5 2.9 5.7 -0.5 2.4
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.1 0.3 -0.3
Medication: Cholesterol lowering 1.5 2.4 2.8 -1.4 -1.7
Depression (self-reported) 1.1 1.4 2.6 -0.3 1.6
Medication: Lansoprazole 1.8 2.1 2.2 1.5 1.4
Prospective memory result 1.9 2.3 4.4 0.5 -2.1
Lung cancer (father) 0.8 0.9 1.6 1.3 -0.5
Illnesses of mother 0.6 0.7 0.9 1.0 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 1.2 1.1 -0.9
Pulse wave Arterial Stiffness index 0.1 0.1 0.1 0.3 0.3
Impedance of arm (left) 2.3 10.8 14.4 3.8 2.7
Arm fat mass (right) 1.2 5.1 10.1 -0.1 -3.2
Trunk predicted mass 1.6 9.4 14.6 -2.1 -3.8
Standing height 0.3 3.0 5.9 0.2 -2.4
Length of working week for main job 1.1 1.2 2.4 -1.5 0.2
Exposure to tobacco smoke at home 0.0 0.0 0.0 -0.1 0.2
Breastfed as a baby 0.3 0.4 0.6 0.5 -0.7
Tense / ‘highly strung’ 2.1 3.4 6.8 -2.6 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 3.4 -1.8 -0.6
Hair/balding pattern: Pattern 4 0.9 2.2 4.3 0.3 -2.1
Birth weight of first child 0.3 0.6 1.1 -0.4 -1.0
Peak expiratory flow (PEF) 1.2 2.7 3.8 -1.3 -2.0
Pulse wave reflection index 0.8 1.0 1.5 -0.8 -1.2
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.3 1.5 0.3
Loud music exposure frequency 1.0 1.1 2.1 1.5 0.3
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.0 -0.1 0.2
Mouth/teeth dental problems: Bleeding gums 6.2 8.1 11.0 -2.3 -3.3
Blood clot in the leg (DVT) 0.1 0.1 0.1 0.4 -0.2
Medication: Paracetamol 0.2 0.3 0.6 -0.1 -0.8
Headache pain in last month 0.8 1.4 1.8 -1.0 -1.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.5 0.5 0.7
Glaucoma (self-reported) 1.8 2.2 4.3 2.1 0.1
Gout (self-reported) 1.3 1.8 3.4 0.5 1.8
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 1.7 -0.4 1.3
Medication: Amlodipine 1.8 2.6 5.0 -0.3 2.2
Medication: Ventolin 100micrograms inhaler 0.6 0.8 0.9 0.8 1.0
Birth weight 0.2 0.3 0.7 -0.8 -0.1
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.3 -0.4 -0.6
High blood pressure (siblings) 0.7 1.1 2.1 0.1 1.4
Forced vital capacity (FVC), Best measure 0.3 1.2 2.2 1.5 -0.3
Body fat percentage 0.7 2.7 5.1 0.5 -2.2
Leg fat percentage (right) 1.4 5.3 9.2 -1.1 -3.0
Arm fat-free mass (right) 2.0 10.4 13.2 -2.8 -3.6
Exposure to tobacco smoke outside home 0.5 0.7 1.3 0.3 1.1
Comparative body size at age 10 0.3 0.9 1.2 -1.1 0.7
Number of full brothers 0.4 0.5 0.8 0.5 0.9
Worry too long after embarrassment 0.0 0.0 0.0 -0.1 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 0.6 0.2 -0.8
Wheeze or whistling in the chest in last year 0.7 1.3 1.4 -1.2 -1.1
Number of children fathered 5.7 6.5 9.8 -1.8 3.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.0 -1.4 0.1
Age at first live birth 1.5 2.7 4.8 -2.2 -0.7
Pulse wave peak to peak time 0.1 0.1 0.1 -0.3 -0.1
Health satisfaction 0.3 0.4 0.5 -0.6 -0.7
Shortness of breath walking on level ground 2.5 2.9 3.1 -1.7 -1.8
Qualifications: College or University degree 0.7 2.3 2.9 1.3 -1.7
Eye problems/disorders: None of the above 0.5 0.6 0.8 -0.9 -0.5
Mouth/teeth dental problems: Loose teeth 3.8 4.5 7.5 -1.2 -2.7
Emphysema/chronic bronchitis 1.6 1.8 3.1 1.8 -0.8
Medication for pain relief, constipation, heartburn 0.4 0.7 1.4 0.2 1.2
Neck or shoulder pain in last month 0.2 0.3 0.4 0.4 -0.7
Medication: Blood pressure 0.0 0.1 0.1 -0.3 -0.3
Angina (self-reported) 1.9 2.5 3.1 -1.4 -1.8
Migraine (self-reported) 0.9 1.1 2.0 0.5 1.4
Medication: Ibuprofen 0.3 0.4 0.4 0.6 -0.6
Medication: Allopurinol 0.4 0.5 0.8 0.5 0.9
Medication: Omeprazole 1.5 1.8 3.3 -0.6 1.8
Medication: Seretide 50 evohaler 0.2 0.2 0.3 0.0 0.6
Mean time to correctly identify matches 2.6 4.9 9.7 3.1 -0.1
Heart disease (mother) 0.4 0.5 0.8 -0.9 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 0.8 -0.5 0.9
Whole body fat mass 1.2 4.9 9.7 -0.3 -3.1
Leg fat mass (right) 1.8 7.0 12.3 -1.3 -3.5
Arm predicted mass (right) 2.1 10.5 14.1 -2.6 -3.8
Pulse rate, automated reading 1.0 3.3 5.2 1.2 2.3
Alcohol intake frequency. 0.3 0.7 1.3 1.1 -0.4
Comparative height size at age 10 0.0 0.1 0.3 0.5 -0.0
Number of full sisters 2.0 2.5 3.9 1.1 2.0
Suffer from ‘nerves’ 0.3 0.4 0.6 -0.8 0.4
Overall health rating 0.2 0.5 1.0 0.0 -1.0
Chest pain or discomfort 3.3 4.7 5.3 -2.3 -2.0
Had major operations 1.2 1.4 2.3 -0.7 -1.5
Age at last live birth 0.8 1.2 2.0 -1.4 0.7
Family relationship satisfaction 0.6 0.8 0.9 -1.0 -0.8
Leg pain on walking 0.2 0.2 0.3 0.4 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 -0.3 0.4
Commuting to job workplace: Car/motor vehicle 0.5 0.6 0.8 -0.6 0.9
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.6 -0.1 -0.8
Medication: Aspirin 1.4 1.8 3.6 -1.9 -0.3
Supplements: Vitamin C 1.5 1.7 3.2 -1.8 -0.5
Knee pain experienced in last month 0.2 0.4 0.7 -0.2 -0.8
Hypertension (Self-reported) 0.2 0.5 1.0 1.0 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.5 2.1 0.9 1.5
Illnesses of father: Heart disease 1.5 2.1 4.2 -2.0 0.2
Illnesses of siblings: Diabetes 0.7 0.9 1.1 -0.9 1.0
Smoking status: Previous 0.3 0.4 0.7 -0.2 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 1.6 0.5 -1.3
Whole body fat-free mass 1.5 8.6 13.6 -1.9 -3.7
Leg fat-free mass (right) 0.8 4.4 8.2 -0.7 -2.9
Arm fat percentage (left) 0.7 2.9 5.0 0.8 -2.2
Average weekly red wine intake 2.0 2.9 5.8 -2.4 0.1
Handedness (chirality/laterality): Left-handed 2.9 3.5 3.8 1.9 1.8
Mood swings 1.1 2.0 3.0 -1.7 -1.1
Loneliness, isolation 0.5 0.6 1.2 -1.1 -0.2
Long-standing illness, disability or infirmity 1.0 1.5 2.9 -1.7 -0.3
Ever had bowel cancer screening 3.0 3.5 4.6 -1.6 -2.1
Diabetes diagnosed by doctor 1.0 1.7 2.1 1.1 1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 0.8 -0.5 -0.9
Friendships satisfaction 0.9 1.1 2.0 0.4 1.4
Qualifications: nursing, teaching 0.0 0.1 0.1 0.0 0.3
Commuting to job workplace: Walk 0.1 0.1 0.1 0.3 -0.0
Eye problems/disorders: Cataract 0.0 0.0 0.0 -0.2 0.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.3 -1.1 0.1
Medication for cholesterol 0.0 0.1 0.1 -0.3 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 0.8 0.9 -0.6
Back pain experienced in last month 0.3 0.4 0.7 0.8 0.4
Mineral and other dietary supplements 0.8 1.1 2.1 1.5 -0.1
Breast cancer (self-reported) 2.1 2.5 4.7 -0.5 -2.2
Asthma (self-reported) 1.5 2.9 5.7 -0.3 2.4
Osteoporosis (self-reported) 2.1 2.6 5.0 2.2 -0.5
Osteoarthritis (self-reported) 0.2 0.2 0.3 0.3 -0.6
Medication: Aspirin 1.6 2.1 4.2 -2.0 -0.1
Medication: Gliclazide 2.0 2.3 4.2 -0.7 -2.0
Illnesses of father: None of the above (group 1) 0.4 0.5 0.8 -0.9 0.3
Smoking status: Current 0.6 1.0 1.2 -0.9 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.5 1.2 -0.5
Whole body water mass 1.6 9.0 14.1 -1.9 -3.8
Leg predicted mass (right) 0.8 4.3 8.1 -0.7 -2.9
Arm fat mass (left) 1.3 5.3 10.4 -0.3 -3.2
Number of self-reported non-cancer illnesses 0.0 0.0 0.0 -0.2 0.2
Average weekly champagne plus white wine intake 0.8 1.1 1.5 -1.2 -0.8
Miserableness 1.1 1.8 1.8 -1.3 -1.4
Guilty feelings 0.4 0.7 1.3 -1.1 -0.1
Wears glasses or contact lenses 1.1 1.3 2.3 1.5 0.5
Ever taken oral contraceptive pill 1.9 2.2 4.1 -0.4 -2.0
Hearing aid user 1.3 1.5 2.3 0.9 1.5
Mother’s age at death 1.4 1.8 3.6 0.1 -1.9
Financial situation satisfaction 0.1 0.2 0.3 0.2 0.5
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.0 0.7 1.0
Commuting to job workplace: Public transport 0.3 0.3 0.5 0.7 -0.5
Eye problems/disorders: Glaucoma 1.6 1.9 3.8 1.9 -0.3
Medication: Blood pressure 0.2 0.4 0.6 0.8 0.4
Pain type(s) experienced in last month: Hip pain 1.0 1.3 2.4 -0.4 1.6
Supplements: Fish oil (including cod liver oil) 0.8 1.0 1.6 -0.6 1.3
High cholesterol (Self-reported) 2.8 5.0 7.5 -1.6 -2.7
Medication: Bendroflumethiazide 0.7 1.0 1.3 0.9 1.2
Medication: Paracetamol 0.1 0.2 0.4 0.2 -0.6
Medication: Lisinopril 1.1 1.4 2.7 -1.6 -0.4
Medication: Atorvastatin 0.7 0.9 1.8 -0.2 -1.3
Illnesses of father: High blood pressure 0.2 0.2 0.4 -0.6 0.3
Alcohol drinker status: Never 0.4 0.5 0.5 0.7 0.7
Ever smoked 0.7 1.2 1.8 -0.7 -1.4
Basal metabolic rate 1.5 8.5 14.3 -1.7 -3.8
Leg fat percentage (left) 1.3 4.6 8.3 -1.0 -2.9
Arm fat-free mass (left) 2.1 10.6 14.4 -2.6 -3.8
Number of operations (self-reported) 0.1 0.2 0.2 -0.4 -0.4
Average weekly beer plus cider intake 0.4 0.6 1.1 -0.1 1.1
Irritability 2.4 4.1 6.0 -1.5 -2.5
Risk taking 1.1 1.6 3.0 -1.7 0.4
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.0 -0.2 0.1
Fractured/broken bones in last 5 years 2.3 2.9 4.4 2.1 -1.2
Age started oral contraceptive pill 1.6 2.0 3.3 -0.8 -1.8
Diastolic blood pressure, automated reading 2.5 7.8 12.4 3.5 1.8
Ever depressed for a whole week 2.3 2.8 5.6 0.1 -2.4
Unable to work because of sickness or disability 0.3 0.3 0.7 -0.8 -0.1
Commuting to job workplace: Cycle 1.7 2.0 3.9 0.4 -2.0
Myopia 0.1 0.2 0.3 -0.4 0.5
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.8 -0.9 -0.2
Cholesterol lowering medication 2.5 3.6 7.0 -0.5 -2.6
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 2.3 0.8 1.5
Pain experienced in last month 0.3 0.4 0.8 -0.2 0.9
Supplements: Calcium 0.5 0.6 0.9 -0.5 -1.0
Basal cell carcinoma (self-reported) 0.2 0.2 0.4 -0.7 -0.1
Heart attack/myocardial infarction (self-reported) 1.9 2.5 3.0 -1.7 -1.4
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.3 0.5 -0.3
Heart disease (siblings) 4.1 5.1 6.5 -1.9 -2.5
Alcohol drinker status: Previous 2.1 2.4 3.4 1.2 1.8
Pack years of smoking 0.0 0.1 0.1 -0.4 -0.1
Impedance of whole body 1.3 6.8 8.3 2.9 2.3
Leg fat mass (left) 1.6 6.2 10.7 -1.3 -3.3
Arm predicted mass (left) 2.5 12.5 16.5 -2.9 -4.1