Hub : Genes

PIK3AP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Coronary	0.391	0.1000	6.6e-04	0.000	NA	0.014	NA	-0.005	0.33	NA	0.110	NA	0.510
2	GTEx	Esophagus Muscularis	0.164	0.0510	5.1e-04	0.000	NA	0.020	NA	0.014	0.33	NA	0.022	NA	0.048
3	YFS	Blood	0.038	0.0121	1.1e-05	0.000	0.013	0.004	0.011	0.002	0.39	3.6e-05	0.016	0.00013	0.067
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.128	0.0490	2.3e-03	-0.003	0.024	0.009	NA	-0.003	0.58	1.6e-02	0.088	NA	0.530

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.8	1.3	2.8	0.9	0.2	1.2	-1.7
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	-0.8	-0.3	0.6	-1.0
Depressed Affect (Nagel 2018)	0.4	0.9	2.9	0.2	0.3	-1.7	-0.7
Depression (Nagel 2018)	0.1	0.1	0.2	-0.4	0.4	-0.1	-0.3
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.2	0.8	1.1	1.1	0.0
Neuroticism (Nagel 2018)	1.3	3.1	8.1	0.9	0.6	-2.9	-1.7
Schizophrenia (2018)	0.4	0.9	3.1	-1.8	-0.6	-0.1	0.1
Schizophrenia vs Biploar Disorder	0.6	0.7	2.0	-1.4	0.3	-0.7	0.5
Worry (Nagel 2018)	1.2	2.6	5.2	0.7	1.4	-2.3	-1.7
Alzheimer’s Disease (in mother)	1.8	2.1	3.2	-1.5	-1.4	-0.9	1.8
Alzheimer’s Disease (in father)	1.3	1.4	3.3	-0.1	-1.4	0.6	1.8
Alzheimer’s Disease (including proxy)	1.6	2.4	5.9	-0.8	-1.6	-0.5	2.4
Crohns Disease (2017)	0.7	1.5	3.5	1.0	1.2	-1.9	-0.5
Irritable Bowel Disease (IBD)	0.2	0.4	1.0	0.4	0.2	-0.6	-1.0
Ulcerative Colitis (UC)	0.2	0.5	1.5	0.4	-0.3	0.3	-1.2
Major Depression (MDD)	4.3	5.2	11.6	2.7	1.2	0.4	-3.4
Reaction Time	1.8	3.5	9.3	-1.2	1.6	-3.0	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.0	1.0	0.7	0.4	0.9
Breast Cancer	0.1	0.2	0.6	-0.1	0.2	0.4	0.8
Ovarian Cancer	1.3	1.7	3.7	-1.9	0.4	-1.3	1.1
Prostate Cancer	0.1	0.1	0.2	-0.5	0.3	0.2	0.1
Age at First Birth	0.5	0.8	1.7	1.3	-0.8	0.4	0.8
Bipolar Disorder (2011)	0.6	0.6	1.1	1.1	0.5	0.0	-0.9
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.2	0.5	0.7	-0.7
Coronary Artery Disease (CAD)	1.1	1.3	4.7	0.8	-2.2	-0.2	0.3
Crohns Disease (2012)	1.1	1.8	5.8	0.8	0.3	-2.4	-0.8
Mean Putamen Volume	3.1	3.5	8.9	1.3	1.8	-3.0	-0.5
Fasting Glucose	1.1	1.3	3.0	-1.7	0.6	-0.6	1.1
HbA1C	0.3	0.3	0.6	0.5	-0.8	0.5	0.4
HDL Cholesterol	0.3	0.5	0.8	-0.9	-0.5	-0.8	0.6
LDL Cholesterol	0.3	0.5	0.7	0.7	-0.6	-0.6	0.8
Lupus	0.6	0.9	2.7	0.7	0.6	1.6	0.4
Neuroticism (2016)	1.1	1.5	3.1	0.9	-0.4	-1.4	-1.8
Primary Biliary Cirrhosis	0.1	0.1	0.4	-0.6	-0.1	-0.3	-0.2
Rheumatoid Arthritis	0.9	1.3	3.1	-1.0	-1.0	0.2	-1.8
Schizophrenia (2014)	0.3	0.6	1.8	-1.3	-0.7	-0.3	0.0
Triglycerides	1.1	1.7	3.4	1.4	-1.8	1.2	-0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.2	1.5	-0.1	-0.9	0.1
Ulcerative Colitis	0.2	0.3	0.6	-0.8	-0.5	0.3	-0.4
Blood Eosinophil Count	0.1	0.8	2.3	-0.7	1.5	-0.3	-0.5
Blood Platelet Count	0.8	9.7	20.0	-1.1	4.5	-3.7	-2.0
Blood Red Count	0.2	1.7	3.3	-1.2	1.8	-1.5	-0.2
Blood White Count	0.4	2.7	7.7	-0.7	1.6	-2.8	-0.2
Heel T-Score	0.6	5.0	13.8	1.4	1.8	-3.7	-0.8
BMI	0.1	0.6	1.5	-0.4	0.6	1.2	-0.5
Height	0.5	10.5	38.2	1.9	0.3	6.2	0.7
Waist Hip Ratio (WHR)	0.2	1.0	2.0	1.2	0.3	1.4	0.6
Systolic Blood Pressure	0.2	1.2	2.2	-0.4	-1.5	-1.5	-0.1
Smoking Status	0.7	1.7	6.4	-2.5	-0.2	0.6	0.4
Allergy or Eczema	0.3	0.9	2.1	-0.2	0.9	-1.5	-0.7
Cardiovascular Disease	0.2	0.6	0.9	0.8	-0.9	-0.1	-0.9
Hypothyroidism (self reported)	1.1	2.4	6.0	0.6	-0.1	1.8	-2.5
Respiratory disease	0.3	0.6	1.4	0.0	0.8	-0.3	-1.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.8	0.3	-0.9	0.3	-0.7
Lung FEV1/FVC ratio	1.1	5.8	17.3	-1.2	-1.4	4.2	1.6
Lung FVC	0.1	0.5	1.6	-0.5	-0.3	-1.3	0.3
Neuroticism	0.4	0.9	2.7	0.1	0.4	-1.6	-0.9
Chronotype (morning person)	1.0	2.2	4.3	2.1	-1.2	1.6	-0.8
Hair Pigment	0.0	0.1	0.2	0.0	0.5	-0.3	-0.4
Tanning	0.2	2.6	6.0	-2.4	1.3	-0.4	1.6
Hand grip strength (left)	0.7	1.8	3.0	-0.9	-1.6	1.7	1.0
Number of treatments/medications taken	0.6	1.1	4.2	0.2	0.5	-0.0	-2.1
Average weekly spirits intake	0.6	0.8	1.7	-0.3	-1.3	0.6	1.0
Sensitivity / hurt feelings	0.3	0.5	1.0	-1.0	0.4	0.1	0.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.2	-1.5	0.3	0.3	0.1
Hearing difficulty/problems: Yes	0.3	0.5	1.1	-0.1	-1.0	1.0	-0.1
Relative age of first facial hair	1.2	2.4	5.7	1.6	1.0	2.4	-0.4
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	5.4	-1.4	0.7	2.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	-0.5	1.0	1.1	0.0
Ever had hysterectomy (womb removed)	1.3	1.5	5.1	2.3	0.7	-0.5	0.4
Systolic blood pressure, automated reading	0.1	0.3	0.6	0.3	-0.1	-0.8	-0.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.9	-1.4	-0.4	0.6	0.2
Angina	0.4	0.5	1.4	0.1	-0.5	-1.2	-0.5
Medication for hormone replacement therapy	0.8	0.8	1.6	-1.1	1.3	-0.7	0.5
Vitamin and mineral supplements	0.6	0.8	1.7	-0.1	0.8	-1.3	-0.8
Supplements: Zinc	1.0	1.1	2.0	1.4	-0.4	-1.0	1.1
Medication: Co-codamol	0.6	0.7	1.6	-1.3	-1.0	0.3	-0.0
Medication: Metformin	0.6	0.8	1.3	1.1	-1.2	0.9	0.3
Diabetes (father)	0.8	1.0	2.0	0.5	1.4	-0.0	-1.3
Diabetes (mother)	0.7	0.8	3.2	0.0	-0.1	0.4	1.8
Severe depression (siblings)	0.4	0.4	1.0	-1.0	0.8	-0.1	-0.1
Pack years adult smoking proportion	1.0	1.5	5.2	-0.2	-0.8	-0.2	-2.3
Impedance of leg (right)	0.4	1.7	4.8	2.2	1.3	0.6	-0.4
Leg fat-free mass (left)	0.4	1.9	6.0	0.3	-1.2	2.5	-0.4
Trunk fat percentage	0.7	2.8	4.8	1.6	1.0	2.2	-1.7
Hand grip strength (right)	0.8	2.2	7.2	-0.7	-1.0	2.7	0.0
Townsend deprivation index at recruitment	0.5	0.7	1.5	-1.2	-0.0	1.1	-0.2
Current tobacco smoking	3.0	4.9	15.3	-3.9	-0.8	1.8	-0.7
Average weekly fortified wine intake	0.5	0.6	1.6	-0.8	1.3	0.2	0.4
Maternal smoking around birth	3.9	5.6	18.9	-4.3	1.7	0.7	-0.5
Fed-up feelings	0.9	1.7	3.7	0.8	1.0	-1.9	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.3	-1.5	1.0	-0.9	-0.0
Relative age voice broke	1.0	1.6	3.4	1.3	1.1	-0.1	-1.9
Taking other prescription medications	0.9	1.4	2.6	-0.7	1.6	0.1	-1.6
Age when periods started (menarche)	0.7	1.6	3.9	0.4	-1.5	2.0	0.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.2	1.0	0.9	-1.5	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.8	1.7	-0.6	-0.0	-0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.2	-1.1	-0.4	-0.7	0.7
Qualifications: CSEs or equivalent	0.6	0.8	1.8	0.9	-1.4	-0.4	-0.6
Serious illness, injury or assault to yourself	1.7	2.1	4.5	-1.3	2.1	0.6	-1.4
High blood pressure	0.0	0.0	0.1	0.2	-0.0	0.0	0.0
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.2	0.0	1.5	-1.1	-0.9
Multivitamins +/- minerals	1.6	2.0	5.3	-0.6	-2.3	1.1	1.1
Stomach or abdominal pain in last month	0.3	0.3	0.6	-0.6	0.5	0.8	-0.3
Supplements: Glucosamine	1.6	2.1	3.6	-0.6	-1.7	1.2	1.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.4	-0.1	0.5	-1.2	-0.1
Medication: Atenolol	1.5	1.9	4.3	1.6	-0.5	-2.1	-0.5
Medication: Levothyroxine sodium	0.9	1.5	3.1	0.3	0.5	1.7	-1.8
Sitting height	0.1	0.7	1.6	0.9	0.2	1.2	-0.5
Chronic bronchitis/emphysema (father)	0.7	0.8	2.1	-1.5	0.3	-0.7	0.7
High blood pressure (mother)	0.6	0.9	1.5	-0.6	1.2	0.8	-0.9
Body mass index (BMI)	0.2	0.8	2.7	-0.3	-0.0	1.6	-0.8
Impedance of leg (left)	0.4	1.8	3.7	1.7	1.9	0.7	-0.4
Leg predicted mass (left)	0.4	2.1	6.3	0.4	-1.3	2.5	-0.4
Trunk fat mass	0.7	3.2	8.0	1.5	0.6	2.8	-1.4
Waist circumference	0.4	1.5	5.0	0.9	0.5	2.2	-0.1
Number of incorrect matches in round	1.6	2.7	4.7	0.4	1.5	-1.9	2.2
Past tobacco smoking	0.1	0.2	0.6	0.8	-0.3	0.4	-0.4
Alcohol usually taken with meals	0.5	0.7	1.7	0.9	-1.3	0.2	0.7
Nervous feelings	0.9	1.7	3.4	0.9	0.7	-1.9	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.6	-0.1	-0.0	-1.3	0.1
Hearing difficulty/problems with background noise	1.0	1.6	3.8	1.6	-0.1	1.9	-0.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.7	0.3	0.4	-1.3	0.6
Had menopause	0.6	0.7	2.7	-0.2	1.6	0.0	-0.2
Had other major operations	0.2	0.2	0.4	0.6	0.2	-0.5	0.2
Forced vital capacity (FVC)	0.2	0.7	1.1	0.4	-0.9	1.1	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	5.9	2.4	-1.0	0.5	-0.0
Ever unenthusiastic/disinterested for a whole week	3.0	3.7	9.4	-3.1	2.0	-0.3	-1.1
Qualifications: None of the above	0.3	0.7	1.9	-0.0	1.0	0.4	-1.4
Financial difficulties in last 2 years	1.3	1.7	3.9	-2.0	0.7	0.2	-1.6
Mouth/teeth dental problems	0.3	0.4	0.9	1.0	-0.1	-0.8	-0.1
Heart attack	1.3	1.6	6.4	-0.3	0.3	-2.5	-0.1
Allergy	0.8	1.9	4.1	0.0	-2.0	0.5	1.8
Pain all over the body in last month	0.7	0.8	1.5	-1.1	1.2	-0.4	0.6
Diabetes (self-reported)	0.7	1.0	2.1	1.4	0.1	-0.4	-1.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	-0.3	0.4	-0.5	0.9
Medication: Ramipril	0.4	0.5	1.5	0.4	-1.2	0.2	-0.5
Medication: Simvastatin	0.9	1.3	3.6	0.6	-1.9	0.1	-1.0
Fluid intelligence score	0.4	0.8	1.5	0.7	0.1	1.0	1.2
Illnesses of siblings	0.9	1.2	2.9	0.5	-1.2	-0.6	1.7
Neuroticism score	0.4	0.8	2.2	-0.1	0.9	-1.5	0.5
Weight	0.6	2.9	10.2	0.9	-0.4	3.2	-0.7
Impedance of arm (right)	0.1	0.5	1.0	0.7	1.0	0.1	-0.6
Arm fat percentage (right)	0.3	1.1	2.2	0.2	0.5	1.4	-1.5
Trunk fat-free mass	0.7	3.9	11.2	1.1	-1.7	3.4	0.4
Hip circumference	0.3	1.3	4.4	0.7	0.6	2.1	-0.4
Time employed in main current job	0.7	0.9	3.1	-1.8	-0.1	-0.5	-0.0
Alcohol intake versus 10 years previously	0.6	0.9	1.6	-0.2	-1.2	-1.3	-0.8
Father’s age at death	1.6	2.2	5.3	2.3	0.0	1.8	0.0
Worrier / anxious feelings	1.4	2.6	6.0	2.4	1.0	-1.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.1	-1.0	1.1	0.5	-0.7
Falls in the last year	0.6	0.8	2.2	-0.9	1.5	-0.5	-0.0
Hair/balding pattern: Pattern 3	0.4	0.5	1.6	-0.5	-1.3	0.4	0.3
Number of live births	0.9	1.3	2.4	-0.7	1.5	1.0	1.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	5.8	-0.1	-1.1	2.4	0.0
Pulse rate	0.2	0.3	0.7	0.8	0.4	-0.7	-0.2
Happiness	0.4	0.5	1.3	0.0	-1.1	0.5	-0.5
Noisy workplace	1.3	1.6	4.6	1.1	-0.7	-0.3	-2.1
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.9	-0.5	-1.4	0.9	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.2	0.2	0.5	0.5	-1.1
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.3	0.0	-0.4	0.3
Asthma	0.6	1.1	4.0	0.6	0.4	0.0	-2.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.4	1.8	0.1	1.0	-0.1
Medication: Cholesterol lowering	1.1	1.7	3.2	0.9	-1.2	-1.8	-1.1
Depression (self-reported)	1.2	1.4	2.5	-1.2	1.2	-0.6	-1.6
Medication: Lansoprazole	0.2	0.3	0.5	-0.7	0.2	-0.7	0.1
Prospective memory result	1.2	1.5	2.4	1.6	-1.3	1.4	0.2
Lung cancer (father)	1.0	1.1	2.3	-1.5	0.9	0.6	1.1
Illnesses of mother	0.4	0.5	1.8	0.3	-1.4	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	5.4	-0.1	-1.2	2.3	0.2
Pulse wave Arterial Stiffness index	0.4	0.4	1.1	1.1	-0.3	0.6	-0.4
Impedance of arm (left)	0.2	0.7	1.3	1.1	1.1	0.3	-0.6
Arm fat mass (right)	0.4	1.5	4.0	0.7	0.4	2.0	-1.1
Trunk predicted mass	0.7	4.0	11.6	1.1	-1.7	3.4	0.5
Standing height	0.7	6.8	17.0	3.1	-0.7	4.1	0.2
Length of working week for main job	0.5	0.6	1.2	-1.1	0.5	-0.9	-0.4
Exposure to tobacco smoke at home	1.7	1.9	5.4	0.7	-1.3	0.1	-2.3
Breastfed as a baby	1.5	1.9	5.9	-0.8	0.9	-0.2	2.4
Tense / ‘highly strung’	1.5	2.5	5.4	-0.7	1.5	-2.3	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.6	-1.0	1.4	-0.1	-1.6
Hair/balding pattern: Pattern 4	0.3	0.6	1.6	-0.6	1.3	-0.7	0.3
Birth weight of first child	0.8	1.5	2.9	1.4	1.7	-0.7	0.7
Peak expiratory flow (PEF)	0.5	1.1	3.4	0.3	-0.9	1.8	-0.4
Pulse wave reflection index	0.3	0.4	0.6	0.5	-0.8	0.6	-0.6
Ever highly irritable/argumentative for 2 days	1.6	2.0	7.2	-2.7	-0.7	-0.0	-0.3
Loud music exposure frequency	0.6	0.7	1.8	-0.6	0.7	0.1	-1.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	5.0	-0.7	-0.3	0.6	2.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.9	-2.2	-0.7	0.6	-1.2
Blood clot in the leg (DVT)	0.7	1.0	2.5	-1.1	1.6	-0.3	-0.4
Medication: Paracetamol	0.4	0.6	1.3	-1.2	-0.9	0.0	0.4
Headache pain in last month	0.9	1.5	2.3	0.3	-1.5	1.5	-1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.8	-0.3	1.3	1.3	0.9
Glaucoma (self-reported)	1.7	2.0	3.3	1.7	1.1	-0.9	-1.8
Gout (self-reported)	0.6	0.9	2.4	0.3	-1.5	0.5	0.9
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	6.3	0.1	-0.4	1.5	-2.5
Medication: Amlodipine	0.5	0.7	2.2	1.5	-0.1	0.6	-0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.6	0.2	0.2	0.1	-1.2
Birth weight	0.5	1.1	2.0	-0.3	-0.8	-1.4	1.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.7	-0.4	1.3	-0.3	0.9
High blood pressure (siblings)	0.7	1.0	1.9	-1.1	0.0	1.0	-1.4
Forced vital capacity (FVC), Best measure	0.3	1.0	2.2	0.7	-0.8	1.5	-0.9
Body fat percentage	0.5	2.1	3.1	1.3	1.1	1.8	-1.6
Leg fat percentage (right)	0.5	1.6	3.8	1.0	0.6	1.9	-1.2
Arm fat-free mass (right)	0.5	2.4	6.8	1.3	-1.0	2.6	0.4
Exposure to tobacco smoke outside home	3.1	4.1	10.5	-1.2	-1.4	-3.2	-1.6
Comparative body size at age 10	0.8	2.1	4.5	0.5	-2.1	0.0	-1.9
Number of full brothers	0.5	0.6	0.8	0.5	0.9	0.8	0.8
Worry too long after embarrassment	1.2	2.0	3.5	-1.2	1.4	-1.9	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	4.5	0.2	2.1	-0.7	-1.6
Wheeze or whistling in the chest in last year	1.2	2.2	3.3	-1.7	1.2	-1.1	-1.8
Number of children fathered	0.7	0.8	1.8	1.4	-0.6	-0.5	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.7	0.8	-0.5	-1.6	1.5
Age at first live birth	0.5	0.9	1.6	1.0	-1.3	0.1	1.0
Pulse wave peak to peak time	0.2	0.3	0.5	-0.7	0.5	-0.3	0.4
Health satisfaction	1.3	1.7	4.9	-0.6	-0.2	2.2	-1.2
Shortness of breath walking on level ground	3.0	3.5	9.4	-0.3	-0.0	3.1	-2.2
Qualifications: College or University degree	0.6	1.8	3.2	1.1	-1.8	1.5	0.9
Eye problems/disorders: None of the above	0.5	0.6	2.0	-0.3	-0.5	1.4	-0.0
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.5	-1.0	-1.9	0.8	-0.5
Emphysema/chronic bronchitis	1.8	2.0	6.2	-2.5	0.9	-0.2	-1.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	-0.6	-0.1	0.5	0.8
Neck or shoulder pain in last month	1.5	2.2	6.8	-0.8	1.0	-2.6	0.6
Medication: Blood pressure	0.7	1.1	2.3	-0.6	-1.3	-1.5	-0.6
Angina (self-reported)	0.2	0.3	1.0	0.1	-0.2	-1.0	-0.3
Migraine (self-reported)	0.2	0.2	0.8	0.1	0.1	0.0	-0.9
Medication: Ibuprofen	1.8	2.2	7.5	2.7	0.8	0.4	-0.6
Medication: Allopurinol	1.4	1.9	5.0	0.5	-2.2	0.7	1.3
Medication: Omeprazole	0.7	0.8	2.9	-0.1	-0.5	1.7	-0.2
Medication: Seretide 50 evohaler	0.3	0.4	1.0	-0.6	1.0	-0.3	0.0
Mean time to correctly identify matches	2.0	3.9	7.9	-0.6	2.4	-2.8	-1.3
Heart disease (mother)	0.6	0.8	2.6	-0.6	0.3	-0.1	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	0.3	-0.2	-0.2	0.1
Whole body fat mass	0.5	2.2	5.5	1.1	0.7	2.3	-1.2
Leg fat mass (right)	0.4	1.7	5.0	0.8	0.1	2.2	-1.0
Arm predicted mass (right)	0.4	2.3	7.0	1.3	-0.6	2.6	0.2
Pulse rate, automated reading	0.2	0.6	1.0	1.0	-0.6	-1.0	-0.5
Alcohol intake frequency.	0.0	0.1	0.3	-0.2	0.2	-0.6	0.2
Comparative height size at age 10	0.2	0.9	2.5	1.0	0.3	1.6	0.3
Number of full sisters	1.0	1.3	4.0	-0.5	-0.9	-0.3	-2.0
Suffer from ‘nerves’	1.2	1.9	3.8	-1.4	1.9	-1.2	0.6
Overall health rating	0.1	0.3	1.1	0.1	0.3	1.0	0.0
Chest pain or discomfort	0.7	1.0	1.9	0.7	-0.2	1.4	-1.3
Had major operations	0.4	0.4	1.4	-1.2	-0.0	-0.1	-0.5
Age at last live birth	0.1	0.1	0.3	-0.2	-0.5	-0.2	0.5
Family relationship satisfaction	1.6	2.0	2.8	-1.3	-1.7	0.9	1.6
Leg pain on walking	1.3	1.6	2.3	1.0	-1.5	1.4	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	5.0	-2.2	-1.3	0.1	1.3
Commuting to job workplace: Car/motor vehicle	1.4	1.6	5.2	0.4	-0.3	1.0	-2.3
Illness, injury, bereavement, stress in last 2 years	3.8	4.7	8.6	1.5	-2.9	-0.0	2.8
Medication: Aspirin	0.7	1.0	2.2	1.0	-0.7	-1.5	-0.4
Supplements: Vitamin C	2.1	2.4	5.2	0.3	-1.2	2.3	1.8
Knee pain experienced in last month	0.9	1.3	3.6	-1.9	0.4	-0.1	1.2
Hypertension (Self-reported)	0.0	0.1	0.3	-0.0	-0.3	0.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.0	-1.0	-0.5	-0.2	-0.7
Illnesses of father: Heart disease	0.9	1.2	2.7	1.6	-1.2	-0.6	-0.5
Illnesses of siblings: Diabetes	0.2	0.3	0.9	-0.3	0.9	0.0	-0.5
Smoking status: Previous	0.4	0.5	1.7	0.5	0.3	-0.3	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.4	-1.0	-1.0	1.2	1.1
Whole body fat-free mass	0.5	3.0	8.9	0.8	-1.5	3.0	0.2
Leg fat-free mass (right)	0.3	1.8	6.1	0.0	-1.1	2.5	-0.3
Arm fat percentage (left)	0.3	1.3	2.6	0.3	0.6	1.6	-1.5
Average weekly red wine intake	0.9	1.3	4.1	0.3	-1.0	2.0	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.2	0.7	-0.3	0.7
Mood swings	0.6	1.0	2.2	-0.6	0.7	-1.5	1.1
Loneliness, isolation	0.7	1.0	2.8	-0.9	-0.0	-1.7	-0.4
Long-standing illness, disability or infirmity	1.1	1.7	3.2	-1.8	1.7	0.9	-0.1
Ever had bowel cancer screening	1.3	1.6	3.2	1.8	0.9	1.3	-0.7
Diabetes diagnosed by doctor	0.3	0.4	1.1	0.8	-0.1	-0.0	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.1	0.8	-0.5	0.8	-1.8
Friendships satisfaction	2.7	3.3	8.6	-0.8	-1.8	0.9	2.9
Qualifications: nursing, teaching	0.9	1.4	2.6	1.6	0.3	-1.5	0.8
Commuting to job workplace: Walk	1.4	1.6	3.8	1.4	-0.7	-0.3	2.0
Eye problems/disorders: Cataract	0.3	0.3	0.9	-0.5	0.1	-0.9	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.7	0.8	1.3	0.1	0.4
Medication for cholesterol	0.3	0.5	1.3	-0.1	-0.6	1.1	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.1	0.8	-0.7	1.0	-0.4
Back pain experienced in last month	0.4	0.6	1.1	-0.8	1.0	0.5	0.6
Mineral and other dietary supplements	0.9	1.2	4.0	0.2	0.5	-0.6	-2.0
Breast cancer (self-reported)	0.3	0.3	1.2	1.1	-0.1	0.3	0.1
Asthma (self-reported)	0.5	0.9	3.4	0.5	0.3	-0.1	-1.8
Osteoporosis (self-reported)	0.5	0.6	1.6	-0.3	-1.3	0.4	0.7
Osteoarthritis (self-reported)	1.2	1.6	3.8	-2.0	0.4	0.8	1.3
Medication: Aspirin	0.7	1.0	1.3	1.1	-1.0	-1.1	-0.5
Medication: Gliclazide	0.0	0.0	0.1	-0.1	0.2	0.0	-0.3
Illnesses of father: None of the above (group 1)	0.6	0.8	2.6	-0.4	-1.6	-0.6	0.0
Smoking status: Current	3.2	5.0	17.1	-4.1	-0.5	1.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.2	-0.5	0.2	-0.6	1.1
Whole body water mass	0.5	3.0	8.9	0.8	-1.5	3.0	0.2
Leg predicted mass (right)	0.4	1.9	6.2	-0.0	-1.1	2.5	-0.4
Arm fat mass (left)	0.4	1.6	5.2	0.6	0.4	2.3	-0.9
Number of self-reported non-cancer illnesses	1.0	1.7	5.6	0.5	0.8	0.6	-2.4
Average weekly champagne plus white wine intake	1.9	2.6	7.5	2.7	-0.5	1.6	-0.2
Miserableness	0.3	0.4	0.7	0.6	0.8	-0.8	0.1
Guilty feelings	0.1	0.1	0.2	0.4	-0.2	-0.3	0.2
Wears glasses or contact lenses	0.3	0.3	0.8	-0.6	0.4	-0.9	-0.4
Ever taken oral contraceptive pill	3.9	4.3	6.6	-2.2	-2.6	1.4	1.9
Hearing aid user	2.7	3.1	7.9	-1.2	2.8	-1.7	0.1
Mother’s age at death	3.7	4.7	14.2	3.8	-0.6	2.0	-0.3
Financial situation satisfaction	2.6	3.2	6.8	-1.6	-2.6	1.7	0.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.1	-0.8	-0.7	0.3
Commuting to job workplace: Public transport	0.7	0.9	1.5	0.9	1.2	-0.4	0.9
Eye problems/disorders: Glaucoma	1.2	1.5	4.4	2.1	0.6	-1.0	-0.4
Medication: Blood pressure	0.3	0.6	1.5	1.2	0.8	0.1	-0.4
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.0	-1.0	-0.2	-0.0	-1.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.3	-0.9	0.1	0.7	1.5
High cholesterol (Self-reported)	1.1	2.0	5.3	2.3	-1.6	-0.5	-0.0
Medication: Bendroflumethiazide	0.2	0.3	0.6	0.8	-0.0	0.5	0.4
Medication: Paracetamol	0.1	0.2	0.4	-0.4	-0.4	0.3	0.6
Medication: Lisinopril	0.2	0.2	0.6	0.3	-0.5	-0.8	0.1
Medication: Atorvastatin	0.8	1.0	1.8	0.8	-1.2	-1.3	0.1
Illnesses of father: High blood pressure	0.6	0.8	2.4	0.2	-0.5	1.6	0.6
Alcohol drinker status: Never	0.9	1.1	2.3	-0.4	1.5	-1.4	-0.2
Ever smoked	0.1	0.2	0.6	-0.8	-0.3	0.4	-0.1
Basal metabolic rate	0.5	3.0	10.0	0.9	-1.2	3.2	-0.1
Leg fat percentage (left)	0.5	1.8	4.0	0.8	1.1	2.0	-1.3
Arm fat-free mass (left)	0.5	2.5	7.2	1.2	-0.9	2.7	0.6
Number of operations (self-reported)	0.3	0.5	0.9	0.3	0.9	-0.8	-0.4
Average weekly beer plus cider intake	0.8	1.2	2.2	-1.5	-0.0	0.8	-1.4
Irritability	0.3	0.6	1.4	0.4	0.3	-1.2	-0.8
Risk taking	0.2	0.3	0.8	-0.2	-0.5	0.9	-0.5
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.6	1.2	-1.2	1.0	0.7
Fractured/broken bones in last 5 years	0.5	0.6	1.1	-1.1	-0.3	-0.8	0.7
Age started oral contraceptive pill	0.8	1.0	2.2	1.1	0.3	0.6	1.5
Diastolic blood pressure, automated reading	0.3	0.8	1.3	1.1	1.2	0.2	-0.8
Ever depressed for a whole week	1.5	1.9	3.0	-1.7	0.9	-1.1	-1.6
Unable to work because of sickness or disability	1.7	2.2	6.5	-2.6	0.0	1.2	-0.9
Commuting to job workplace: Cycle	2.2	2.7	4.6	-2.1	-1.3	-0.1	2.1
Myopia	0.8	1.1	3.5	0.2	-0.6	0.7	1.9
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	-0.3	0.4	0.9	0.0
Cholesterol lowering medication	1.1	1.6	4.2	0.7	-2.0	1.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.2	0.2	-0.6	1.5	0.0
Pain experienced in last month	0.2	0.3	0.7	0.1	-0.3	0.6	-0.8
Supplements: Calcium	1.1	1.2	3.7	-0.9	-0.6	0.4	1.9
Basal cell carcinoma (self-reported)	1.3	1.6	2.8	-1.2	1.7	-1.2	0.8
Heart attack/myocardial infarction (self-reported)	1.0	1.3	5.0	-0.2	0.0	-2.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.8	-0.8	1.7	-0.4	-0.5
Heart disease (siblings)	0.4	0.5	1.1	0.3	0.7	-0.5	-1.1
Alcohol drinker status: Previous	0.9	1.1	4.1	2.0	-0.1	0.1	-0.3
Pack years of smoking	0.8	1.2	3.5	0.1	-0.9	-0.6	-1.9
Impedance of whole body	0.3	1.5	3.2	1.8	1.6	0.3	-0.6
Leg fat mass (left)	0.5	1.9	5.6	0.8	0.4	2.4	-1.2
Arm predicted mass (left)	0.4	2.0	6.1	1.0	-1.0	2.5	0.2