Hub : Genes

PIK3AP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.391 0.1000 6.6e-04 0.000 NA 0.014 NA -0.005 0.33 NA 0.110 NA 0.510
2 GTEx Esophagus Muscularis 0.164 0.0510 5.1e-04 0.000 NA 0.020 NA 0.014 0.33 NA 0.022 NA 0.048
3 YFS Blood 0.038 0.0121 1.1e-05 0.000 0.013 0.004 0.011 0.002 0.39 3.6e-05 0.016 0.00013 0.067
4 TCGA Kidney Renal Papillary Cell Carcinoma 0.128 0.0490 2.3e-03 -0.003 0.024 0.009 NA -0.003 0.58 1.6e-02 0.088 NA 0.530

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.8 1.3 2.8 0.9 0.2 1.2 -1.7
Bipolar Disorder or Schizophrenia 0.2 0.5 1.0 -0.8 -0.3 0.6 -1.0
Depressed Affect (Nagel 2018) 0.4 0.9 2.9 0.2 0.3 -1.7 -0.7
Depression (Nagel 2018) 0.1 0.1 0.2 -0.4 0.4 -0.1 -0.3
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.2 0.8 1.1 1.1 0.0
Neuroticism (Nagel 2018) 1.3 3.1 8.1 0.9 0.6 -2.9 -1.7
Schizophrenia (2018) 0.4 0.9 3.1 -1.8 -0.6 -0.1 0.1
Schizophrenia vs Biploar Disorder 0.6 0.7 2.0 -1.4 0.3 -0.7 0.5
Worry (Nagel 2018) 1.2 2.6 5.2 0.7 1.4 -2.3 -1.7
Alzheimer’s Disease (in mother) 1.8 2.1 3.2 -1.5 -1.4 -0.9 1.8
Alzheimer’s Disease (in father) 1.3 1.4 3.3 -0.1 -1.4 0.6 1.8
Alzheimer’s Disease (including proxy) 1.6 2.4 5.9 -0.8 -1.6 -0.5 2.4
Crohns Disease (2017) 0.7 1.5 3.5 1.0 1.2 -1.9 -0.5
Irritable Bowel Disease (IBD) 0.2 0.4 1.0 0.4 0.2 -0.6 -1.0
Ulcerative Colitis (UC) 0.2 0.5 1.5 0.4 -0.3 0.3 -1.2
Major Depression (MDD) 4.3 5.2 11.6 2.7 1.2 0.4 -3.4
Reaction Time 1.8 3.5 9.3 -1.2 1.6 -3.0 -0.9
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.0 1.0 0.7 0.4 0.9
Breast Cancer 0.1 0.2 0.6 -0.1 0.2 0.4 0.8
Ovarian Cancer 1.3 1.7 3.7 -1.9 0.4 -1.3 1.1
Prostate Cancer 0.1 0.1 0.2 -0.5 0.3 0.2 0.1
Age at First Birth 0.5 0.8 1.7 1.3 -0.8 0.4 0.8
Bipolar Disorder (2011) 0.6 0.6 1.1 1.1 0.5 0.0 -0.9
Body Mass Index (BMI) (2010) 0.2 0.3 0.5 0.2 0.5 0.7 -0.7
Coronary Artery Disease (CAD) 1.1 1.3 4.7 0.8 -2.2 -0.2 0.3
Crohns Disease (2012) 1.1 1.8 5.8 0.8 0.3 -2.4 -0.8
Mean Putamen Volume 3.1 3.5 8.9 1.3 1.8 -3.0 -0.5
Fasting Glucose 1.1 1.3 3.0 -1.7 0.6 -0.6 1.1
HbA1C 0.3 0.3 0.6 0.5 -0.8 0.5 0.4
HDL Cholesterol 0.3 0.5 0.8 -0.9 -0.5 -0.8 0.6
LDL Cholesterol 0.3 0.5 0.7 0.7 -0.6 -0.6 0.8
Lupus 0.6 0.9 2.7 0.7 0.6 1.6 0.4
Neuroticism (2016) 1.1 1.5 3.1 0.9 -0.4 -1.4 -1.8
Primary Biliary Cirrhosis 0.1 0.1 0.4 -0.6 -0.1 -0.3 -0.2
Rheumatoid Arthritis 0.9 1.3 3.1 -1.0 -1.0 0.2 -1.8
Schizophrenia (2014) 0.3 0.6 1.8 -1.3 -0.7 -0.3 0.0
Triglycerides 1.1 1.7 3.4 1.4 -1.8 1.2 -0.5
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.2 1.5 -0.1 -0.9 0.1
Ulcerative Colitis 0.2 0.3 0.6 -0.8 -0.5 0.3 -0.4
Blood Eosinophil Count 0.1 0.8 2.3 -0.7 1.5 -0.3 -0.5
Blood Platelet Count 0.8 9.7 20.0 -1.1 4.5 -3.7 -2.0
Blood Red Count 0.2 1.7 3.3 -1.2 1.8 -1.5 -0.2
Blood White Count 0.4 2.7 7.7 -0.7 1.6 -2.8 -0.2
Heel T-Score 0.6 5.0 13.8 1.4 1.8 -3.7 -0.8
BMI 0.1 0.6 1.5 -0.4 0.6 1.2 -0.5
Height 0.5 10.5 38.2 1.9 0.3 6.2 0.7
Waist Hip Ratio (WHR) 0.2 1.0 2.0 1.2 0.3 1.4 0.6
Systolic Blood Pressure 0.2 1.2 2.2 -0.4 -1.5 -1.5 -0.1
Smoking Status 0.7 1.7 6.4 -2.5 -0.2 0.6 0.4
Allergy or Eczema 0.3 0.9 2.1 -0.2 0.9 -1.5 -0.7
Cardiovascular Disease 0.2 0.6 0.9 0.8 -0.9 -0.1 -0.9
Hypothyroidism (self reported) 1.1 2.4 6.0 0.6 -0.1 1.8 -2.5
Respiratory disease 0.3 0.6 1.4 0.0 0.8 -0.3 -1.2
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.8 0.3 -0.9 0.3 -0.7
Lung FEV1/FVC ratio 1.1 5.8 17.3 -1.2 -1.4 4.2 1.6
Lung FVC 0.1 0.5 1.6 -0.5 -0.3 -1.3 0.3
Neuroticism 0.4 0.9 2.7 0.1 0.4 -1.6 -0.9
Chronotype (morning person) 1.0 2.2 4.3 2.1 -1.2 1.6 -0.8
Hair Pigment 0.0 0.1 0.2 0.0 0.5 -0.3 -0.4
Tanning 0.2 2.6 6.0 -2.4 1.3 -0.4 1.6
Hand grip strength (left) 0.7 1.8 3.0 -0.9 -1.6 1.7 1.0
Number of treatments/medications taken 0.6 1.1 4.2 0.2 0.5 -0.0 -2.1
Average weekly spirits intake 0.6 0.8 1.7 -0.3 -1.3 0.6 1.0
Sensitivity / hurt feelings 0.3 0.5 1.0 -1.0 0.4 0.1 0.9
Frequency of depressed mood in last 2 weeks 0.4 0.6 2.2 -1.5 0.3 0.3 0.1
Hearing difficulty/problems: Yes 0.3 0.5 1.1 -0.1 -1.0 1.0 -0.1
Relative age of first facial hair 1.2 2.4 5.7 1.6 1.0 2.4 -0.4
Other serious medical condition/disability diagnosed by doctor 1.5 2.0 5.4 -1.4 0.7 2.3 -0.5
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.1 -0.5 1.0 1.1 0.0
Ever had hysterectomy (womb removed) 1.3 1.5 5.1 2.3 0.7 -0.5 0.4
Systolic blood pressure, automated reading 0.1 0.3 0.6 0.3 -0.1 -0.8 -0.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.9 -1.4 -0.4 0.6 0.2
Angina 0.4 0.5 1.4 0.1 -0.5 -1.2 -0.5
Medication for hormone replacement therapy 0.8 0.8 1.6 -1.1 1.3 -0.7 0.5
Vitamin and mineral supplements 0.6 0.8 1.7 -0.1 0.8 -1.3 -0.8
Supplements: Zinc 1.0 1.1 2.0 1.4 -0.4 -1.0 1.1
Medication: Co-codamol 0.6 0.7 1.6 -1.3 -1.0 0.3 -0.0
Medication: Metformin 0.6 0.8 1.3 1.1 -1.2 0.9 0.3
Diabetes (father) 0.8 1.0 2.0 0.5 1.4 -0.0 -1.3
Diabetes (mother) 0.7 0.8 3.2 0.0 -0.1 0.4 1.8
Severe depression (siblings) 0.4 0.4 1.0 -1.0 0.8 -0.1 -0.1
Pack years adult smoking proportion 1.0 1.5 5.2 -0.2 -0.8 -0.2 -2.3
Impedance of leg (right) 0.4 1.7 4.8 2.2 1.3 0.6 -0.4
Leg fat-free mass (left) 0.4 1.9 6.0 0.3 -1.2 2.5 -0.4
Trunk fat percentage 0.7 2.8 4.8 1.6 1.0 2.2 -1.7
Hand grip strength (right) 0.8 2.2 7.2 -0.7 -1.0 2.7 0.0
Townsend deprivation index at recruitment 0.5 0.7 1.5 -1.2 -0.0 1.1 -0.2
Current tobacco smoking 3.0 4.9 15.3 -3.9 -0.8 1.8 -0.7
Average weekly fortified wine intake 0.5 0.6 1.6 -0.8 1.3 0.2 0.4
Maternal smoking around birth 3.9 5.6 18.9 -4.3 1.7 0.7 -0.5
Fed-up feelings 0.9 1.7 3.7 0.8 1.0 -1.9 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.3 -1.5 1.0 -0.9 -0.0
Relative age voice broke 1.0 1.6 3.4 1.3 1.1 -0.1 -1.9
Taking other prescription medications 0.9 1.4 2.6 -0.7 1.6 0.1 -1.6
Age when periods started (menarche) 0.7 1.6 3.9 0.4 -1.5 2.0 0.4
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 2.2 1.0 0.9 -1.5 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.8 1.7 -0.6 -0.0 -0.6
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.2 -1.1 -0.4 -0.7 0.7
Qualifications: CSEs or equivalent 0.6 0.8 1.8 0.9 -1.4 -0.4 -0.6
Serious illness, injury or assault to yourself 1.7 2.1 4.5 -1.3 2.1 0.6 -1.4
High blood pressure 0.0 0.0 0.1 0.2 -0.0 0.0 0.0
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.2 0.0 1.5 -1.1 -0.9
Multivitamins +/- minerals 1.6 2.0 5.3 -0.6 -2.3 1.1 1.1
Stomach or abdominal pain in last month 0.3 0.3 0.6 -0.6 0.5 0.8 -0.3
Supplements: Glucosamine 1.6 2.1 3.6 -0.6 -1.7 1.2 1.9
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.4 -0.1 0.5 -1.2 -0.1
Medication: Atenolol 1.5 1.9 4.3 1.6 -0.5 -2.1 -0.5
Medication: Levothyroxine sodium 0.9 1.5 3.1 0.3 0.5 1.7 -1.8
Sitting height 0.1 0.7 1.6 0.9 0.2 1.2 -0.5
Chronic bronchitis/emphysema (father) 0.7 0.8 2.1 -1.5 0.3 -0.7 0.7
High blood pressure (mother) 0.6 0.9 1.5 -0.6 1.2 0.8 -0.9
Body mass index (BMI) 0.2 0.8 2.7 -0.3 -0.0 1.6 -0.8
Impedance of leg (left) 0.4 1.8 3.7 1.7 1.9 0.7 -0.4
Leg predicted mass (left) 0.4 2.1 6.3 0.4 -1.3 2.5 -0.4
Trunk fat mass 0.7 3.2 8.0 1.5 0.6 2.8 -1.4
Waist circumference 0.4 1.5 5.0 0.9 0.5 2.2 -0.1
Number of incorrect matches in round 1.6 2.7 4.7 0.4 1.5 -1.9 2.2
Past tobacco smoking 0.1 0.2 0.6 0.8 -0.3 0.4 -0.4
Alcohol usually taken with meals 0.5 0.7 1.7 0.9 -1.3 0.2 0.7
Nervous feelings 0.9 1.7 3.4 0.9 0.7 -1.9 -1.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.6 -0.1 -0.0 -1.3 0.1
Hearing difficulty/problems with background noise 1.0 1.6 3.8 1.6 -0.1 1.9 -0.0
Hair/balding pattern: Pattern 2 0.5 0.6 1.7 0.3 0.4 -1.3 0.6
Had menopause 0.6 0.7 2.7 -0.2 1.6 0.0 -0.2
Had other major operations 0.2 0.2 0.4 0.6 0.2 -0.5 0.2
Forced vital capacity (FVC) 0.2 0.7 1.1 0.4 -0.9 1.1 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 5.9 2.4 -1.0 0.5 -0.0
Ever unenthusiastic/disinterested for a whole week 3.0 3.7 9.4 -3.1 2.0 -0.3 -1.1
Qualifications: None of the above 0.3 0.7 1.9 -0.0 1.0 0.4 -1.4
Financial difficulties in last 2 years 1.3 1.7 3.9 -2.0 0.7 0.2 -1.6
Mouth/teeth dental problems 0.3 0.4 0.9 1.0 -0.1 -0.8 -0.1
Heart attack 1.3 1.6 6.4 -0.3 0.3 -2.5 -0.1
Allergy 0.8 1.9 4.1 0.0 -2.0 0.5 1.8
Pain all over the body in last month 0.7 0.8 1.5 -1.1 1.2 -0.4 0.6
Diabetes (self-reported) 0.7 1.0 2.1 1.4 0.1 -0.4 -1.4
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.8 -0.3 0.4 -0.5 0.9
Medication: Ramipril 0.4 0.5 1.5 0.4 -1.2 0.2 -0.5
Medication: Simvastatin 0.9 1.3 3.6 0.6 -1.9 0.1 -1.0
Fluid intelligence score 0.4 0.8 1.5 0.7 0.1 1.0 1.2
Illnesses of siblings 0.9 1.2 2.9 0.5 -1.2 -0.6 1.7
Neuroticism score 0.4 0.8 2.2 -0.1 0.9 -1.5 0.5
Weight 0.6 2.9 10.2 0.9 -0.4 3.2 -0.7
Impedance of arm (right) 0.1 0.5 1.0 0.7 1.0 0.1 -0.6
Arm fat percentage (right) 0.3 1.1 2.2 0.2 0.5 1.4 -1.5
Trunk fat-free mass 0.7 3.9 11.2 1.1 -1.7 3.4 0.4
Hip circumference 0.3 1.3 4.4 0.7 0.6 2.1 -0.4
Time employed in main current job 0.7 0.9 3.1 -1.8 -0.1 -0.5 -0.0
Alcohol intake versus 10 years previously 0.6 0.9 1.6 -0.2 -1.2 -1.3 -0.8
Father’s age at death 1.6 2.2 5.3 2.3 0.0 1.8 0.0
Worrier / anxious feelings 1.4 2.6 6.0 2.4 1.0 -1.6 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.1 -1.0 1.1 0.5 -0.7
Falls in the last year 0.6 0.8 2.2 -0.9 1.5 -0.5 -0.0
Hair/balding pattern: Pattern 3 0.4 0.5 1.6 -0.5 -1.3 0.4 0.3
Number of live births 0.9 1.3 2.4 -0.7 1.5 1.0 1.1
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 5.8 -0.1 -1.1 2.4 0.0
Pulse rate 0.2 0.3 0.7 0.8 0.4 -0.7 -0.2
Happiness 0.4 0.5 1.3 0.0 -1.1 0.5 -0.5
Noisy workplace 1.3 1.6 4.6 1.1 -0.7 -0.3 -2.1
Qualifications: A levels/AS levels or equivalent 0.8 1.7 3.9 -0.5 -1.4 0.9 2.0
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.2 0.2 0.5 0.5 -1.1
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 0.3 0.0 -0.4 0.3
Asthma 0.6 1.1 4.0 0.6 0.4 0.0 -2.0
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 3.4 1.8 0.1 1.0 -0.1
Medication: Cholesterol lowering 1.1 1.7 3.2 0.9 -1.2 -1.8 -1.1
Depression (self-reported) 1.2 1.4 2.5 -1.2 1.2 -0.6 -1.6
Medication: Lansoprazole 0.2 0.3 0.5 -0.7 0.2 -0.7 0.1
Prospective memory result 1.2 1.5 2.4 1.6 -1.3 1.4 0.2
Lung cancer (father) 1.0 1.1 2.3 -1.5 0.9 0.6 1.1
Illnesses of mother 0.4 0.5 1.8 0.3 -1.4 0.2 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 5.4 -0.1 -1.2 2.3 0.2
Pulse wave Arterial Stiffness index 0.4 0.4 1.1 1.1 -0.3 0.6 -0.4
Impedance of arm (left) 0.2 0.7 1.3 1.1 1.1 0.3 -0.6
Arm fat mass (right) 0.4 1.5 4.0 0.7 0.4 2.0 -1.1
Trunk predicted mass 0.7 4.0 11.6 1.1 -1.7 3.4 0.5
Standing height 0.7 6.8 17.0 3.1 -0.7 4.1 0.2
Length of working week for main job 0.5 0.6 1.2 -1.1 0.5 -0.9 -0.4
Exposure to tobacco smoke at home 1.7 1.9 5.4 0.7 -1.3 0.1 -2.3
Breastfed as a baby 1.5 1.9 5.9 -0.8 0.9 -0.2 2.4
Tense / ‘highly strung’ 1.5 2.5 5.4 -0.7 1.5 -2.3 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 2.6 -1.0 1.4 -0.1 -1.6
Hair/balding pattern: Pattern 4 0.3 0.6 1.6 -0.6 1.3 -0.7 0.3
Birth weight of first child 0.8 1.5 2.9 1.4 1.7 -0.7 0.7
Peak expiratory flow (PEF) 0.5 1.1 3.4 0.3 -0.9 1.8 -0.4
Pulse wave reflection index 0.3 0.4 0.6 0.5 -0.8 0.6 -0.6
Ever highly irritable/argumentative for 2 days 1.6 2.0 7.2 -2.7 -0.7 -0.0 -0.3
Loud music exposure frequency 0.6 0.7 1.8 -0.6 0.7 0.1 -1.3
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 5.0 -0.7 -0.3 0.6 2.2
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 4.9 -2.2 -0.7 0.6 -1.2
Blood clot in the leg (DVT) 0.7 1.0 2.5 -1.1 1.6 -0.3 -0.4
Medication: Paracetamol 0.4 0.6 1.3 -1.2 -0.9 0.0 0.4
Headache pain in last month 0.9 1.5 2.3 0.3 -1.5 1.5 -1.2
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 1.8 -0.3 1.3 1.3 0.9
Glaucoma (self-reported) 1.7 2.0 3.3 1.7 1.1 -0.9 -1.8
Gout (self-reported) 0.6 0.9 2.4 0.3 -1.5 0.5 0.9
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 6.3 0.1 -0.4 1.5 -2.5
Medication: Amlodipine 0.5 0.7 2.2 1.5 -0.1 0.6 -0.4
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.6 0.2 0.2 0.1 -1.2
Birth weight 0.5 1.1 2.0 -0.3 -0.8 -1.4 1.3
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.7 -0.4 1.3 -0.3 0.9
High blood pressure (siblings) 0.7 1.0 1.9 -1.1 0.0 1.0 -1.4
Forced vital capacity (FVC), Best measure 0.3 1.0 2.2 0.7 -0.8 1.5 -0.9
Body fat percentage 0.5 2.1 3.1 1.3 1.1 1.8 -1.6
Leg fat percentage (right) 0.5 1.6 3.8 1.0 0.6 1.9 -1.2
Arm fat-free mass (right) 0.5 2.4 6.8 1.3 -1.0 2.6 0.4
Exposure to tobacco smoke outside home 3.1 4.1 10.5 -1.2 -1.4 -3.2 -1.6
Comparative body size at age 10 0.8 2.1 4.5 0.5 -2.1 0.0 -1.9
Number of full brothers 0.5 0.6 0.8 0.5 0.9 0.8 0.8
Worry too long after embarrassment 1.2 2.0 3.5 -1.2 1.4 -1.9 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 4.5 0.2 2.1 -0.7 -1.6
Wheeze or whistling in the chest in last year 1.2 2.2 3.3 -1.7 1.2 -1.1 -1.8
Number of children fathered 0.7 0.8 1.8 1.4 -0.6 -0.5 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 2.7 0.8 -0.5 -1.6 1.5
Age at first live birth 0.5 0.9 1.6 1.0 -1.3 0.1 1.0
Pulse wave peak to peak time 0.2 0.3 0.5 -0.7 0.5 -0.3 0.4
Health satisfaction 1.3 1.7 4.9 -0.6 -0.2 2.2 -1.2
Shortness of breath walking on level ground 3.0 3.5 9.4 -0.3 -0.0 3.1 -2.2
Qualifications: College or University degree 0.6 1.8 3.2 1.1 -1.8 1.5 0.9
Eye problems/disorders: None of the above 0.5 0.6 2.0 -0.3 -0.5 1.4 -0.0
Mouth/teeth dental problems: Loose teeth 1.1 1.3 3.5 -1.0 -1.9 0.8 -0.5
Emphysema/chronic bronchitis 1.8 2.0 6.2 -2.5 0.9 -0.2 -1.0
Medication for pain relief, constipation, heartburn 0.2 0.3 0.6 -0.6 -0.1 0.5 0.8
Neck or shoulder pain in last month 1.5 2.2 6.8 -0.8 1.0 -2.6 0.6
Medication: Blood pressure 0.7 1.1 2.3 -0.6 -1.3 -1.5 -0.6
Angina (self-reported) 0.2 0.3 1.0 0.1 -0.2 -1.0 -0.3
Migraine (self-reported) 0.2 0.2 0.8 0.1 0.1 0.0 -0.9
Medication: Ibuprofen 1.8 2.2 7.5 2.7 0.8 0.4 -0.6
Medication: Allopurinol 1.4 1.9 5.0 0.5 -2.2 0.7 1.3
Medication: Omeprazole 0.7 0.8 2.9 -0.1 -0.5 1.7 -0.2
Medication: Seretide 50 evohaler 0.3 0.4 1.0 -0.6 1.0 -0.3 0.0
Mean time to correctly identify matches 2.0 3.9 7.9 -0.6 2.4 -2.8 -1.3
Heart disease (mother) 0.6 0.8 2.6 -0.6 0.3 -0.1 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.1 0.1 0.3 -0.2 -0.2 0.1
Whole body fat mass 0.5 2.2 5.5 1.1 0.7 2.3 -1.2
Leg fat mass (right) 0.4 1.7 5.0 0.8 0.1 2.2 -1.0
Arm predicted mass (right) 0.4 2.3 7.0 1.3 -0.6 2.6 0.2
Pulse rate, automated reading 0.2 0.6 1.0 1.0 -0.6 -1.0 -0.5
Alcohol intake frequency. 0.0 0.1 0.3 -0.2 0.2 -0.6 0.2
Comparative height size at age 10 0.2 0.9 2.5 1.0 0.3 1.6 0.3
Number of full sisters 1.0 1.3 4.0 -0.5 -0.9 -0.3 -2.0
Suffer from ‘nerves’ 1.2 1.9 3.8 -1.4 1.9 -1.2 0.6
Overall health rating 0.1 0.3 1.1 0.1 0.3 1.0 0.0
Chest pain or discomfort 0.7 1.0 1.9 0.7 -0.2 1.4 -1.3
Had major operations 0.4 0.4 1.4 -1.2 -0.0 -0.1 -0.5
Age at last live birth 0.1 0.1 0.3 -0.2 -0.5 -0.2 0.5
Family relationship satisfaction 1.6 2.0 2.8 -1.3 -1.7 0.9 1.6
Leg pain on walking 1.3 1.6 2.3 1.0 -1.5 1.4 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 5.0 -2.2 -1.3 0.1 1.3
Commuting to job workplace: Car/motor vehicle 1.4 1.6 5.2 0.4 -0.3 1.0 -2.3
Illness, injury, bereavement, stress in last 2 years 3.8 4.7 8.6 1.5 -2.9 -0.0 2.8
Medication: Aspirin 0.7 1.0 2.2 1.0 -0.7 -1.5 -0.4
Supplements: Vitamin C 2.1 2.4 5.2 0.3 -1.2 2.3 1.8
Knee pain experienced in last month 0.9 1.3 3.6 -1.9 0.4 -0.1 1.2
Hypertension (Self-reported) 0.0 0.1 0.3 -0.0 -0.3 0.2 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.0 -1.0 -0.5 -0.2 -0.7
Illnesses of father: Heart disease 0.9 1.2 2.7 1.6 -1.2 -0.6 -0.5
Illnesses of siblings: Diabetes 0.2 0.3 0.9 -0.3 0.9 0.0 -0.5
Smoking status: Previous 0.4 0.5 1.7 0.5 0.3 -0.3 1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 1.4 -1.0 -1.0 1.2 1.1
Whole body fat-free mass 0.5 3.0 8.9 0.8 -1.5 3.0 0.2
Leg fat-free mass (right) 0.3 1.8 6.1 0.0 -1.1 2.5 -0.3
Arm fat percentage (left) 0.3 1.3 2.6 0.3 0.6 1.6 -1.5
Average weekly red wine intake 0.9 1.3 4.1 0.3 -1.0 2.0 -0.3
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.5 -0.2 0.7 -0.3 0.7
Mood swings 0.6 1.0 2.2 -0.6 0.7 -1.5 1.1
Loneliness, isolation 0.7 1.0 2.8 -0.9 -0.0 -1.7 -0.4
Long-standing illness, disability or infirmity 1.1 1.7 3.2 -1.8 1.7 0.9 -0.1
Ever had bowel cancer screening 1.3 1.6 3.2 1.8 0.9 1.3 -0.7
Diabetes diagnosed by doctor 0.3 0.4 1.1 0.8 -0.1 -0.0 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 3.1 0.8 -0.5 0.8 -1.8
Friendships satisfaction 2.7 3.3 8.6 -0.8 -1.8 0.9 2.9
Qualifications: nursing, teaching 0.9 1.4 2.6 1.6 0.3 -1.5 0.8
Commuting to job workplace: Walk 1.4 1.6 3.8 1.4 -0.7 -0.3 2.0
Eye problems/disorders: Cataract 0.3 0.3 0.9 -0.5 0.1 -0.9 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.7 0.8 1.3 0.1 0.4
Medication for cholesterol 0.3 0.5 1.3 -0.1 -0.6 1.1 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.1 0.8 -0.7 1.0 -0.4
Back pain experienced in last month 0.4 0.6 1.1 -0.8 1.0 0.5 0.6
Mineral and other dietary supplements 0.9 1.2 4.0 0.2 0.5 -0.6 -2.0
Breast cancer (self-reported) 0.3 0.3 1.2 1.1 -0.1 0.3 0.1
Asthma (self-reported) 0.5 0.9 3.4 0.5 0.3 -0.1 -1.8
Osteoporosis (self-reported) 0.5 0.6 1.6 -0.3 -1.3 0.4 0.7
Osteoarthritis (self-reported) 1.2 1.6 3.8 -2.0 0.4 0.8 1.3
Medication: Aspirin 0.7 1.0 1.3 1.1 -1.0 -1.1 -0.5
Medication: Gliclazide 0.0 0.0 0.1 -0.1 0.2 0.0 -0.3
Illnesses of father: None of the above (group 1) 0.6 0.8 2.6 -0.4 -1.6 -0.6 0.0
Smoking status: Current 3.2 5.0 17.1 -4.1 -0.5 1.5 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.2 -0.5 0.2 -0.6 1.1
Whole body water mass 0.5 3.0 8.9 0.8 -1.5 3.0 0.2
Leg predicted mass (right) 0.4 1.9 6.2 -0.0 -1.1 2.5 -0.4
Arm fat mass (left) 0.4 1.6 5.2 0.6 0.4 2.3 -0.9
Number of self-reported non-cancer illnesses 1.0 1.7 5.6 0.5 0.8 0.6 -2.4
Average weekly champagne plus white wine intake 1.9 2.6 7.5 2.7 -0.5 1.6 -0.2
Miserableness 0.3 0.4 0.7 0.6 0.8 -0.8 0.1
Guilty feelings 0.1 0.1 0.2 0.4 -0.2 -0.3 0.2
Wears glasses or contact lenses 0.3 0.3 0.8 -0.6 0.4 -0.9 -0.4
Ever taken oral contraceptive pill 3.9 4.3 6.6 -2.2 -2.6 1.4 1.9
Hearing aid user 2.7 3.1 7.9 -1.2 2.8 -1.7 0.1
Mother’s age at death 3.7 4.7 14.2 3.8 -0.6 2.0 -0.3
Financial situation satisfaction 2.6 3.2 6.8 -1.6 -2.6 1.7 0.8
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.7 0.1 -0.8 -0.7 0.3
Commuting to job workplace: Public transport 0.7 0.9 1.5 0.9 1.2 -0.4 0.9
Eye problems/disorders: Glaucoma 1.2 1.5 4.4 2.1 0.6 -1.0 -0.4
Medication: Blood pressure 0.3 0.6 1.5 1.2 0.8 0.1 -0.4
Pain type(s) experienced in last month: Hip pain 0.8 1.0 3.0 -1.0 -0.2 -0.0 -1.7
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.3 -0.9 0.1 0.7 1.5
High cholesterol (Self-reported) 1.1 2.0 5.3 2.3 -1.6 -0.5 -0.0
Medication: Bendroflumethiazide 0.2 0.3 0.6 0.8 -0.0 0.5 0.4
Medication: Paracetamol 0.1 0.2 0.4 -0.4 -0.4 0.3 0.6
Medication: Lisinopril 0.2 0.2 0.6 0.3 -0.5 -0.8 0.1
Medication: Atorvastatin 0.8 1.0 1.8 0.8 -1.2 -1.3 0.1
Illnesses of father: High blood pressure 0.6 0.8 2.4 0.2 -0.5 1.6 0.6
Alcohol drinker status: Never 0.9 1.1 2.3 -0.4 1.5 -1.4 -0.2
Ever smoked 0.1 0.2 0.6 -0.8 -0.3 0.4 -0.1
Basal metabolic rate 0.5 3.0 10.0 0.9 -1.2 3.2 -0.1
Leg fat percentage (left) 0.5 1.8 4.0 0.8 1.1 2.0 -1.3
Arm fat-free mass (left) 0.5 2.5 7.2 1.2 -0.9 2.7 0.6
Number of operations (self-reported) 0.3 0.5 0.9 0.3 0.9 -0.8 -0.4
Average weekly beer plus cider intake 0.8 1.2 2.2 -1.5 -0.0 0.8 -1.4
Irritability 0.3 0.6 1.4 0.4 0.3 -1.2 -0.8
Risk taking 0.2 0.3 0.8 -0.2 -0.5 0.9 -0.5
Ever had prostate specific antigen (PSA) test 1.0 1.1 1.6 1.2 -1.2 1.0 0.7
Fractured/broken bones in last 5 years 0.5 0.6 1.1 -1.1 -0.3 -0.8 0.7
Age started oral contraceptive pill 0.8 1.0 2.2 1.1 0.3 0.6 1.5
Diastolic blood pressure, automated reading 0.3 0.8 1.3 1.1 1.2 0.2 -0.8
Ever depressed for a whole week 1.5 1.9 3.0 -1.7 0.9 -1.1 -1.6
Unable to work because of sickness or disability 1.7 2.2 6.5 -2.6 0.0 1.2 -0.9
Commuting to job workplace: Cycle 2.2 2.7 4.6 -2.1 -1.3 -0.1 2.1
Myopia 0.8 1.1 3.5 0.2 -0.6 0.7 1.9
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.8 -0.3 0.4 0.9 0.0
Cholesterol lowering medication 1.1 1.6 4.2 0.7 -2.0 1.1 0.7
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 2.2 0.2 -0.6 1.5 0.0
Pain experienced in last month 0.2 0.3 0.7 0.1 -0.3 0.6 -0.8
Supplements: Calcium 1.1 1.2 3.7 -0.9 -0.6 0.4 1.9
Basal cell carcinoma (self-reported) 1.3 1.6 2.8 -1.2 1.7 -1.2 0.8
Heart attack/myocardial infarction (self-reported) 1.0 1.3 5.0 -0.2 0.0 -2.2 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.8 -0.8 1.7 -0.4 -0.5
Heart disease (siblings) 0.4 0.5 1.1 0.3 0.7 -0.5 -1.1
Alcohol drinker status: Previous 0.9 1.1 4.1 2.0 -0.1 0.1 -0.3
Pack years of smoking 0.8 1.2 3.5 0.1 -0.9 -0.6 -1.9
Impedance of whole body 0.3 1.5 3.2 1.8 1.6 0.3 -0.6
Leg fat mass (left) 0.5 1.9 5.6 0.8 0.4 2.4 -1.2
Arm predicted mass (left) 0.4 2.0 6.1 1.0 -1.0 2.5 0.2