TWAS hub - PIK3CG

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0282	0.0101	0.00089	0.007	0.010	0.009	0.01	0.009	0.00190	0.00027	0.00054	0.00016	0.00032
2	TCGA	Brain Lower Grade Glioma	0.0626	0.0342	0.00950	0.027	0.004	0.005	NA	0.016	0.00042	0.09300	0.07600	NA	0.00530

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Breast cancer (self-reported)	7.7	9.2	14.3	3.8	2.0
Blood Platelet Count	5.3	61.2	121.0	-11.0	-1.2
Unable to work because of sickness or disability	5.1	6.7	8.9	-2.1	-3.0
Past tobacco smoking	3.8	6.9	9.0	3.0	2.2
Triglycerides	3.5	5.7	10.4	1.0	3.2
Ever smoked	3.4	5.9	8.1	-2.9	-1.9
Exposure to tobacco smoke outside home	3.2	4.3	7.0	-1.3	-2.6
Medication: Bendroflumethiazide	3.0	4.6	5.1	-2.3	-2.0
Alzheimer’s Disease (in mother)	2.7	3.2	3.5	-1.7	-1.9
Lung cancer (father)	2.7	3.1	3.5	-1.7	-1.9
Birth weight of first child	2.7	4.9	7.8	2.8	1.4
Diabetes (mother)	2.6	3.4	5.1	-1.3	-2.3
Smoking status: Previous	2.4	3.6	4.8	-2.2	-1.5
Alcohol usually taken with meals	2.3	3.7	4.5	2.1	1.7
Fluid intelligence score	2.3	4.8	5.7	-2.0	-2.4
Number of children fathered	2.3	2.6	4.0	2.0	1.1
Verbal and Numeric Reasoning (VNR)	2.2	5.2	5.3	-2.3	-2.2
Number of self-reported non-cancer illnesses	2.2	3.8	7.6	-2.8	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	4.6	-2.1	-1.0
Illnesses of father: Heart disease	2.1	2.9	5.1	-2.3	0.9
Fractured/broken bones in last 5 years	2.1	2.6	3.4	-1.4	-1.9
Coronary Artery Disease (CAD)	2.0	2.4	4.5	-0.5	-2.1
Taking other prescription medications	2.0	3.1	6.2	-2.5	0.2
Medication for cholesterol	2.0	3.1	3.7	1.9	1.6
Alzheimer’s Disease (including proxy)	1.9	2.7	3.0	-1.6	-1.7
Depression (self-reported)	1.9	2.3	3.0	-1.3	-1.7
Wheeze or whistling in the chest in last year	1.9	3.4	5.8	-2.4	-1.0
Commuting to job workplace: Car/motor vehicle	1.9	2.2	3.5	-1.9	-0.9
Angina	1.8	2.4	4.4	0.6	2.1
Angina (self-reported)	1.8	2.4	4.5	0.6	2.1
High cholesterol (Self-reported)	1.8	3.2	6.5	-2.5	-0.2
HDL Cholesterol	1.7	2.8	5.0	-0.8	-2.2
Type 2 Diabetes (T2D) (2012)	1.7	1.9	3.8	2.0	0.2
Medication: Co-codamol	1.7	2.0	2.2	-1.3	-1.5
Noisy workplace	1.7	2.1	4.0	-2.0	-0.5
Tense / ‘highly strung’	1.7	2.8	2.8	-1.7	-1.7
Mean Putamen Volume	1.6	1.9	3.7	0.1	1.9
Heart disease (siblings)	1.6	2.0	3.8	-1.9	-0.3
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.9	-2.0	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	2.8	-1.7	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	3.8	-2.0	-0.8
Supplements: Vitamin C	1.5	1.7	3.0	-1.7	0.7
Osteoporosis (self-reported)	1.5	1.8	3.5	-1.9	-0.3
Ever had hysterectomy (womb removed)	1.4	1.6	3.0	1.7	-0.5
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.8	1.7	0.6
Illnesses of siblings: Diabetes	1.4	1.7	2.2	-1.1	-1.5
Pain all over the body in last month	1.3	1.4	1.6	-1.1	-1.3
Number of live births	1.3	1.9	3.2	-1.8	-0.7
Hearing aid user	1.3	1.5	1.7	-1.2	1.3
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.2	-1.5	-0.9
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.0	-1.4	-1.1
Nervous feelings	1.2	2.2	2.9	1.7	1.3
Medication: Simvastatin	1.2	1.7	2.9	-1.7	-0.7
Exposure to tobacco smoke at home	1.2	1.3	1.9	-0.9	-1.4
Medication: Aspirin	1.2	1.6	1.7	1.3	1.2
Ever taken oral contraceptive pill	1.2	1.3	2.5	-1.6	-0.3
Body Mass Index (BMI) (2010)	1.1	1.5	1.6	1.2	1.3
Chronotype (morning person)	1.1	2.6	4.6	2.1	0.7
Stomach or abdominal pain in last month	1.1	1.4	1.8	-1.3	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	3.0	-0.8	-1.7
Prospective memory result	1.1	1.3	2.0	-0.8	-1.4
Age at first live birth	1.1	1.9	2.5	1.2	1.6
Pulse wave peak to peak time	1.1	1.3	1.7	1.3	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.4	-1.6	-0.3
Medication: Aspirin	1.1	1.4	1.6	1.2	1.2
Alcohol drinker status: Never	1.1	1.3	2.5	1.6	0.3
Diastolic blood pressure, automated reading	1.1	3.4	4.1	-2.0	-1.6
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.2	0.6	-1.5
Loud music exposure frequency	1.0	1.0	1.5	0.8	1.2
Gout (self-reported)	1.0	1.4	2.7	0.2	1.6
Ever had bowel cancer screening	1.0	1.2	2.0	1.4	0.6
Irritability	1.0	1.7	2.1	-1.4	-1.1
Major Depression (MDD)	0.9	1.1	1.5	1.2	-0.8
Number of treatments/medications taken	0.9	1.7	3.2	-1.8	-0.5
Multivitamins +/- minerals	0.9	1.2	1.7	1.3	-0.8
Falls in the last year	0.9	1.2	2.0	-0.6	-1.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.3	0.2	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.1	-1.5	-0.1
Health satisfaction	0.9	1.2	1.8	-0.7	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.5	-1.2	-0.6
Supplements: Calcium	0.9	1.0	1.2	-1.1	-0.8
Intelligence (Savage-Jansen 2018)	0.8	2.5	2.9	-1.7	-1.5
Prostate Cancer	0.8	1.2	2.3	-1.5	0.0
Age at First Birth	0.8	1.1	2.2	-0.2	1.5
LDL Cholesterol	0.8	1.3	1.9	-1.4	-0.8
Smoking Status	0.8	2.0	3.0	-1.7	-1.0
Lung FVC	0.8	4.1	6.3	-2.5	-1.4
Average weekly spirits intake	0.8	1.0	1.9	1.4	0.3
Townsend deprivation index at recruitment	0.8	1.2	2.0	-1.4	-0.5
Fed-up feelings	0.8	1.5	3.0	1.7	0.0
Relative age voice broke	0.8	1.2	1.3	-1.1	-1.1
Age when periods started (menarche)	0.8	2.0	2.3	-1.5	-1.3
Serious illness, injury or assault to yourself	0.8	1.0	1.8	-0.5	-1.3
Medication: Levothyroxine sodium	0.8	1.3	1.5	-1.2	1.1
Chronic bronchitis/emphysema (father)	0.8	0.9	1.6	0.5	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.0	0.9	1.7
Pulse wave Arterial Stiffness index	0.8	1.0	1.1	-1.1	-0.9
Alcohol intake frequency.	0.8	2.0	3.5	1.9	0.6
Leg pain on walking	0.8	1.0	1.1	-1.0	-1.0
Mood swings	0.8	1.5	1.5	1.2	-1.2
Friendships satisfaction	0.8	1.0	1.2	-1.1	-1.0
Schizophrenia (2018)	0.7	1.4	2.4	1.5	0.6
Schizophrenia (2014)	0.7	1.5	2.9	1.7	-0.1
Respiratory disease	0.7	1.5	3.0	-1.7	-0.1
Length of working week for main job	0.7	0.8	1.4	1.2	0.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.8	-0.6	-1.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.8	-1.7	0.1
High blood pressure (siblings)	0.7	1.0	1.0	1.0	1.0
Comparative body size at age 10	0.7	1.9	2.7	-1.1	-1.6
Number of full brothers	0.7	0.9	1.6	-1.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.6	-1.2	-0.5
Overall health rating	0.7	1.6	2.0	-1.1	-1.4
Long-standing illness, disability or infirmity	0.7	1.0	1.4	-1.2	0.8
Osteoarthritis (self-reported)	0.7	0.9	1.0	-0.9	1.0
Wears glasses or contact lenses	0.7	0.8	1.4	-1.2	-0.3
Risk taking	0.7	1.0	1.9	0.2	1.4
Age started oral contraceptive pill	0.7	0.8	1.6	-1.2	-0.3
Commuting to job workplace: Cycle	0.7	0.8	1.7	1.3	0.1
Cholesterol lowering medication	0.7	1.0	1.5	-1.2	-0.6
Bipolar Disorder or Schizophrenia	0.6	1.5	3.0	1.7	-0.1
Schizophrenia vs Biploar Disorder	0.6	0.8	1.5	0.4	1.2
Primary Biliary Cirrhosis	0.6	0.9	1.7	1.3	-0.1
Hypothyroidism (self reported)	0.6	1.4	2.4	-1.6	0.6
Supplements: Zinc	0.6	0.7	0.9	1.0	0.7
Illnesses of siblings	0.6	0.8	1.3	-1.1	-0.6
Medication: Cholesterol lowering	0.6	0.9	1.0	-1.0	0.8
Age at last live birth	0.6	0.9	1.7	-1.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.0	-0.7	-1.4
Eye problems/disorders: Cataract	0.6	0.7	0.8	-0.8	-0.9
Medication: Gliclazide	0.6	0.7	1.4	-1.2	-0.3
Illnesses of father: None of the above (group 1)	0.6	0.8	1.4	-0.4	-1.2
Average weekly champagne plus white wine intake	0.6	0.8	1.0	1.0	0.7
Mother’s age at death	0.6	0.8	1.5	-1.2	-0.3
Medication: Blood pressure	0.6	1.1	1.7	-0.7	-1.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	0.8	0.9	0.7
Bipolar Disorder (2018)	0.5	0.8	1.0	0.8	-1.0
Depression (Nagel 2018)	0.5	0.8	1.5	0.4	-1.2
Breast Cancer	0.5	1.1	1.9	-0.6	1.4
Waist Hip Ratio (WHR)	0.5	2.4	3.0	1.3	1.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.3	-0.4	-1.1
Diabetes (father)	0.5	0.6	1.1	1.0	0.4
Severe depression (siblings)	0.5	0.5	0.8	0.9	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.4	0.9	1.2
High blood pressure	0.5	1.3	1.4	-1.1	-1.2
High blood pressure (mother)	0.5	0.8	1.5	-0.1	-1.2
Illnesses of mother	0.5	0.6	0.8	0.7	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.8	-0.1	-1.3
Glaucoma (self-reported)	0.5	0.6	1.2	1.1	0.1
Eye problems/disorders: None of the above	0.5	0.6	1.2	-0.0	1.1
Heart disease (mother)	0.5	0.6	0.7	-0.9	0.6
Number of full sisters	0.5	0.6	1.1	-1.1	0.1
Hypertension (Self-reported)	0.5	1.4	1.7	-1.3	-1.1
Alcohol drinker status: Previous	0.5	0.6	0.8	0.9	0.6
Reaction Time	0.4	0.7	0.7	-0.8	-0.9
Neuroticism (2016)	0.4	0.6	1.0	1.0	-0.4
Cardiovascular Disease	0.4	1.2	2.2	-1.5	-0.3
Lung FEV1/FVC ratio	0.4	2.2	4.4	2.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.0	1.0	-0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-1.0	-0.1
Supplements: Glucosamine	0.4	0.6	1.2	-1.1	0.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.8	0.1	-0.9
Sitting height	0.4	2.9	5.3	2.3	-0.7
Had menopause	0.4	0.6	1.0	-0.3	-1.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	0.3	0.9
Mouth/teeth dental problems	0.4	0.6	1.1	-0.2	1.1
Time employed in main current job	0.4	0.4	0.5	-0.7	-0.6
Alcohol intake versus 10 years previously	0.4	0.7	1.3	0.0	-1.1
Worrier / anxious feelings	0.4	0.8	1.0	1.0	0.8
Breastfed as a baby	0.4	0.5	1.0	-1.0	0.2
Pulse wave reflection index	0.4	0.5	0.9	0.4	-0.9
Medication: Seretide 50 evohaler	0.4	0.5	0.9	-0.3	-1.0
Suffer from ‘nerves’	0.4	0.6	1.3	-1.1	0.1
Guilty feelings	0.4	0.6	1.1	-1.1	-0.3
Eye problems/disorders: Glaucoma	0.4	0.5	0.6	0.7	-0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.6	0.7	0.8	0.6
Medication: Lisinopril	0.4	0.5	0.8	-0.6	-0.9
Number of operations (self-reported)	0.4	0.6	1.0	-1.0	0.5
Myopia	0.4	0.5	0.6	0.7	0.8
Alzheimer’s Disease (in father)	0.3	0.4	0.7	-0.2	-0.8
Blood Red Count	0.3	2.4	2.6	1.6	1.5
Hearing difficulty/problems: Yes	0.3	0.4	0.5	-0.7	-0.5
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.8	-0.2
Medication: Metformin	0.3	0.4	0.7	-0.2	0.9
Hand grip strength (right)	0.3	0.8	1.5	1.2	0.4
Had other major operations	0.3	0.3	0.4	-0.6	0.5
Diabetes (self-reported)	0.3	0.4	0.4	-0.6	0.6
Arm fat percentage (right)	0.3	1.2	2.0	-1.4	-0.6
Trunk fat-free mass	0.3	1.7	3.3	1.8	0.3
Trunk predicted mass	0.3	1.5	2.9	1.7	0.2
Standing height	0.3	3.0	5.6	2.4	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	0.8	-0.4
Emphysema/chronic bronchitis	0.3	0.3	0.4	0.6	-0.5
Medication: Allopurinol	0.3	0.4	0.7	-0.9	0.3
Medication: Omeprazole	0.3	0.3	0.3	-0.5	-0.5
Mean time to correctly identify matches	0.3	0.6	0.9	-0.9	-0.5
Comparative height size at age 10	0.3	1.4	1.5	1.2	1.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.3	-0.6	0.6
Commuting to job workplace: Walk	0.3	0.3	0.6	0.8	-0.0
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.0	1.0	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.5	0.7	-0.4
Pack years of smoking	0.3	0.4	0.9	-0.9	0.0
Bipolar Disorder (2011)	0.2	0.2	0.2	0.5	-0.5
Fasting Glucose	0.2	0.2	0.3	-0.2	-0.6
Heel T-Score	0.2	1.2	2.1	1.4	-0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.5	0.7	-0.5	0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	-0.8	-0.0
Pack years adult smoking proportion	0.2	0.3	0.6	-0.8	0.1
Leg fat-free mass (left)	0.2	0.9	1.8	1.4	-0.1
Current tobacco smoking	0.2	0.3	0.3	-0.5	0.6
Average weekly fortified wine intake	0.2	0.3	0.5	0.2	0.7
Leg predicted mass (left)	0.2	0.9	1.8	1.4	-0.1
Qualifications: None of the above	0.2	0.5	1.0	-0.2	1.0
Financial difficulties in last 2 years	0.2	0.3	0.6	0.8	0.1
Father’s age at death	0.2	0.2	0.3	-0.4	0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.7	-0.3	-0.9
Blood clot in the leg (DVT)	0.2	0.3	0.5	0.7	-0.4
Medication: Paracetamol	0.2	0.3	0.6	-0.0	0.7
Headache pain in last month	0.2	0.3	0.5	0.3	0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.4	0.6	0.4
Birth weight	0.2	0.5	1.0	0.2	1.0
Arm fat-free mass (right)	0.2	1.2	2.5	1.6	0.0
Shortness of breath walking on level ground	0.2	0.3	0.3	0.6	-0.5
Migraine (self-reported)	0.2	0.3	0.5	-0.3	0.7
Arm predicted mass (right)	0.2	0.9	1.8	1.3	0.1
Pulse rate, automated reading	0.2	0.8	1.5	-1.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	-0.7	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	-0.5	-0.4
Whole body fat-free mass	0.2	1.4	2.7	1.6	0.3
Leg fat-free mass (right)	0.2	1.3	2.5	1.6	0.1
Arm fat percentage (left)	0.2	0.8	1.2	-1.1	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	0.7	-0.3
Loneliness, isolation	0.2	0.2	0.4	-0.7	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	0.4	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.2	-0.5	-0.4
Back pain experienced in last month	0.2	0.2	0.4	-0.3	-0.7
Asthma (self-reported)	0.2	0.4	0.5	-0.7	0.5
Smoking status: Current	0.2	0.3	0.3	-0.5	0.6
Whole body water mass	0.2	1.3	2.6	1.6	0.2
Leg predicted mass (right)	0.2	1.1	2.2	1.5	0.1
Illnesses of father: High blood pressure	0.2	0.2	0.3	0.4	0.5
Basal metabolic rate	0.2	1.2	2.4	1.6	0.2
Arm fat-free mass (left)	0.2	1.1	2.2	1.5	0.1
Arm predicted mass (left)	0.2	0.9	1.8	1.4	-0.1
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	0.8	-0.0
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.1	-0.7
Worry (Nagel 2018)	0.1	0.3	0.3	0.5	0.5
Ulcerative Colitis (UC)	0.1	0.3	0.5	0.2	-0.7
Ovarian Cancer	0.1	0.1	0.2	-0.2	0.5
HbA1C	0.1	0.2	0.3	-0.2	0.5
Ulcerative Colitis	0.1	0.1	0.2	-0.1	-0.4
Blood White Count	0.1	0.5	0.7	-0.5	0.8
Systolic Blood Pressure	0.1	0.3	0.7	0.8	-0.1
Tanning	0.1	0.7	1.2	-1.1	-0.3
Sensitivity / hurt feelings	0.1	0.1	0.2	0.3	-0.4
Relative age of first facial hair	0.1	0.2	0.4	0.1	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.3	-0.4
Vitamin and mineral supplements	0.1	0.1	0.2	-0.4	0.0
Impedance of leg (right)	0.1	0.4	0.8	-0.9	0.2
Trunk fat percentage	0.1	0.3	0.5	-0.7	-0.3
Maternal smoking around birth	0.1	0.1	0.1	-0.1	0.4
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.1	0.6
Medication: Atenolol	0.1	0.1	0.2	0.4	-0.2
Impedance of leg (left)	0.1	0.5	0.8	-0.9	0.3
Waist circumference	0.1	0.4	0.5	0.7	0.5
Number of incorrect matches in round	0.1	0.1	0.2	0.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.1	-0.3	-0.3
Forced vital capacity (FVC)	0.1	0.6	0.6	-0.7	-0.8
Allergy	0.1	0.1	0.2	0.1	0.5
Medication: Ramipril	0.1	0.1	0.2	-0.1	0.4
Weight	0.1	0.4	0.7	0.8	-0.2
Hip circumference	0.1	0.2	0.3	0.6	-0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	0.5	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.4	-0.6	-0.5
Happiness	0.1	0.1	0.2	0.3	-0.4
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	-0.0	0.5
Asthma	0.1	0.2	0.3	-0.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	-0.0	0.6
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	-0.5	-0.3
Medication: Amlodipine	0.1	0.2	0.3	-0.1	0.6
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.0	0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.4	-0.7	-0.5
Body fat percentage	0.1	0.6	1.1	-1.0	-0.3
Leg fat percentage (right)	0.1	0.4	0.7	-0.9	-0.4
Worry too long after embarrassment	0.1	0.1	0.1	-0.4	0.2
Qualifications: College or University degree	0.1	0.4	0.7	0.2	0.8
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	-0.0	-0.6
Neck or shoulder pain in last month	0.1	0.2	0.2	0.4	0.4
Medication: Blood pressure	0.1	0.2	0.3	-0.5	-0.4
Medication: Ibuprofen	0.1	0.2	0.2	0.4	0.4
Chest pain or discomfort	0.1	0.2	0.4	0.1	-0.6
Had major operations	0.1	0.2	0.3	0.3	0.5
Family relationship satisfaction	0.1	0.1	0.1	-0.4	-0.1
Knee pain experienced in last month	0.1	0.1	0.3	-0.1	0.5
Average weekly red wine intake	0.1	0.2	0.3	0.3	0.5
Diabetes diagnosed by doctor	0.1	0.1	0.1	-0.4	0.4
Qualifications: nursing, teaching	0.1	0.1	0.1	-0.4	-0.3
Mineral and other dietary supplements	0.1	0.1	0.2	0.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.2	-0.4	-0.4
Miserableness	0.1	0.2	0.3	-0.3	0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.2	-0.5	0.3
Medication: Paracetamol	0.1	0.1	0.2	-0.4	-0.1
Leg fat percentage (left)	0.1	0.5	0.7	-0.9	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.4	0.1
Ever depressed for a whole week	0.1	0.2	0.2	0.4	-0.4
Pain experienced in last month	0.1	0.2	0.4	-0.6	-0.1
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.4	0.2
Impedance of whole body	0.1	0.3	0.5	-0.7	-0.1
Crohns Disease (2017)	0.0	0.1	0.2	-0.4	-0.2
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.1	-0.3
Crohns Disease (2012)	0.0	0.0	0.0	0.1	-0.2
Lupus	0.0	0.0	0.1	-0.3	-0.0
Rheumatoid Arthritis	0.0	0.0	0.1	-0.2	0.0
Blood Eosinophil Count	0.0	0.2	0.3	-0.6	-0.2
BMI	0.0	0.2	0.4	-0.0	-0.6
Height	0.0	0.0	0.0	0.0	-0.1
Allergy or Eczema	0.0	0.0	0.0	-0.1	0.0
Neuroticism	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.1	0.2	0.1	0.5
Hand grip strength (left)	0.0	0.1	0.2	0.4	-0.1
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.3	-0.5
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	-0.0	-0.3
Body mass index (BMI)	0.0	0.2	0.2	-0.4	-0.4
Trunk fat mass	0.0	0.1	0.1	-0.2	-0.4
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.3	0.0
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	0.3	0.1
Heart attack	0.0	0.1	0.1	0.3	0.1
Neuroticism score	0.0	0.1	0.1	-0.0	0.3
Impedance of arm (right)	0.0	0.1	0.2	-0.5	0.0
Pulse rate	0.0	0.0	0.0	-0.1	0.1
Medication: Lansoprazole	0.0	0.0	0.0	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	-0.5	-0.2
Impedance of arm (left)	0.0	0.0	0.1	-0.0	0.2
Arm fat mass (right)	0.0	0.1	0.1	-0.3	-0.3
Peak expiratory flow (PEF)	0.0	0.1	0.2	0.4	0.1
Whole body fat mass	0.0	0.1	0.2	-0.5	-0.2
Leg fat mass (right)	0.0	0.2	0.2	-0.5	-0.3
Arm fat mass (left)	0.0	0.1	0.2	-0.2	-0.4
Financial situation satisfaction	0.0	0.0	0.0	-0.0	0.1
Commuting to job workplace: Public transport	0.0	0.0	0.0	-0.1	-0.0
Medication: Atorvastatin	0.0	0.0	0.0	-0.1	-0.1
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	0.1	0.1
Leg fat mass (left)	0.0	0.2	0.2	-0.5	-0.4

Hub : Genes

PIK3CG

Models

Trait associations