TWAS hub - PKD2L1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2110	0.0460	4.6e-10	0.120	0.116	0.133	0.112	0.136	2.2e-14	6.0e-14	7.0e-16	1.5e-13	3.2e-16
2	ROSMAP	Brain Pre-frontal Cortex	0.1755	0.0355	4.2e-13	0.120	0.136	0.160	0.152	0.155	4.1e-15	4.3e-17	4.5e-20	4.8e-19	1.7e-19
3	TCGA	Breast Invasive Carcinoma	0.0743	0.0232	1.7e-13	0.071	0.071	0.060	NA	0.072	2.0e-14	2.8e-14	2.2e-12	NA	1.6e-14
4	TCGA	Glioblastoma Multiforme	0.2300	0.0840	7.6e-04	0.119	0.043	0.048	NA	0.107	1.9e-04	1.9e-02	1.4e-02	NA	3.9e-04
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0527	0.0224	1.8e-04	0.014	0.017	0.030	NA	0.021	9.3e-03	5.0e-03	2.1e-04	NA	1.7e-03
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0359	0.0168	1.6e-03	0.049	0.016	0.036	NA	0.046	3.4e-06	5.3e-03	5.7e-05	NA	5.8e-06
7	TCGA	Lung Adenocarcinoma	0.0796	0.0320	1.4e-05	0.011	0.029	0.041	NA	0.046	1.6e-02	2.0e-04	1.2e-05	NA	3.8e-06
8	TCGA	Lung Squamous Cell Carcinoma	0.0742	0.0263	2.9e-07	0.051	0.059	0.062	NA	0.059	1.6e-06	2.7e-07	1.5e-07	NA	2.8e-07
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0820	0.0340	2.7e-04	0.108	0.057	0.097	NA	0.102	9.1e-08	1.0e-04	4.4e-07	NA	2.1e-07
10	TCGA	Prostate Adenocarcinoma	0.0709	0.0333	1.1e-03	0.003	0.013	0.009	NA	0.013	1.6e-01	1.6e-02	3.7e-02	NA	1.4e-02
11	TCGA	Soft Tissue Sarcoma	0.0600	0.0270	2.3e-03	0.017	0.027	0.031	NA	0.029	3.4e-02	9.1e-03	5.6e-03	NA	7.9e-03
12	TCGA	Testicular Germ Cell Tumors	0.2590	0.0810	7.4e-07	0.215	0.176	0.183	NA	0.203	4.0e-08	7.9e-07	4.9e-07	NA	1.0e-07
13	TCGA	Thyroid Carcinoma	0.0690	0.0300	2.9e-04	0.050	0.034	0.045	NA	0.052	1.2e-05	2.6e-04	3.4e-05	NA	8.3e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Tinnitus: Yes, but not now, but have in the past	5.8	6.1	9.8	1.0	0.7	2.9	2.0	3.1	2.8	2.9	2.7	2.8	1.7	2.6	2.9	2.8
Type 2 Diabetes (T2D) (2012)	4.7	5.4	12.1	-1.4	0.6	-2.0	-3.0	-2.0	-2.5	-3.5	-3.2	-2.5	0.1	-2.6	-1.5	-2.5
Medication: Ventolin 100micrograms inhaler	3.5	4.6	7.5	1.7	2.2	-2.6	-2.2	-1.4	-2.6	-1.0	-1.5	-2.6	-1.4	-2.7	-2.3	-2.6
Diverticular disease/diverticulitis (self-reported)	3.3	3.9	6.1	-0.7	-0.4	-2.3	-2.1	-1.9	-2.5	-2.5	-1.8	-2.5	-1.5	-2.0	-1.8	-2.5
Mineral and other dietary supplements	3.2	4.3	8.0	-0.4	-1.2	2.4	1.5	2.5	2.0	1.6	2.4	2.0	1.8	2.8	2.8	2.0
Qualifications: CSEs or equivalent	3.1	4.2	7.1	0.5	0.3	2.2	2.3	2.2	2.0	2.2	1.8	2.0	2.7	2.2	2.6	2.0
Supplements: Glucosamine	3.1	4.0	7.0	1.5	2.1	-2.1	-1.8	-1.3	-2.2	-1.2	-2.4	-2.2	-1.9	-2.6	-1.9	-2.2
Prospective memory result	3.1	3.8	6.0	-1.1	0.1	2.5	1.7	2.0	2.4	1.2	1.9	2.4	1.5	2.3	2.3	2.4
Bipolar Disorder or Schizophrenia	3.0	7.3	12.7	0.0	1.7	3.6	2.6	2.8	3.3	2.1	2.4	3.3	1.5	2.8	3.6	3.3
Intelligence (Savage-Jansen 2018)	2.7	8.2	14.6	2.3	0.2	-3.8	-2.5	-1.9	-3.6	-1.4	-2.4	-3.6	-2.4	-3.3	-3.8	-3.6
Wears glasses or contact lenses	2.7	3.1	7.5	1.7	2.0	-1.7	-1.6	-1.3	-1.7	-0.4	-1.3	-1.7	-2.7	-2.3	-1.8	-1.7
Schizophrenia (2014)	2.6	5.8	10.2	-1.6	0.6	3.1	2.6	2.4	2.8	1.0	2.4	2.8	1.5	2.7	3.2	2.8
Number of incorrect matches in round	2.6	4.2	6.8	-0.8	1.2	2.6	2.0	1.9	2.5	1.6	1.7	2.5	2.1	1.7	2.5	2.5
Number of live births	2.6	3.7	6.0	-1.0	-0.4	2.4	1.7	2.1	2.3	0.9	1.2	2.3	2.1	2.3	2.2	2.3
Age when periods started (menarche)	2.5	6.0	11.1	-2.4	-2.6	2.6	2.6	1.6	2.8	0.9	1.9	2.8	3.3	2.7	1.9	2.8
Schizophrenia (2018)	2.4	5.0	9.9	-0.6	1.2	2.9	2.2	2.4	2.6	1.5	2.4	2.6	1.0	2.5	3.1	2.6
Major Depression (MDD)	2.3	2.7	5.0	-1.2	-0.5	2.1	1.9	0.4	2.2	1.1	1.2	2.2	0.6	1.9	1.9	2.2
Pack years adult smoking proportion	2.3	3.4	5.8	-1.3	-0.8	2.2	1.8	1.1	2.4	0.8	1.5	2.4	1.8	2.4	1.8	2.4
Prostate Cancer	2.1	3.0	6.2	-0.6	-0.4	-2.1	-1.7	-2.5	-1.8	-1.4	-1.5	-1.8	-0.7	-2.2	-2.4	-1.8
Relative age voice broke	2.1	3.3	5.5	-1.5	-1.4	-1.9	-1.7	-1.6	-1.9	-2.4	-2.1	-1.9	-1.8	-1.4	-1.8	-1.9
Gout (self-reported)	2.1	2.9	7.0	1.2	1.9	-1.6	-1.6	-2.1	-1.4	-0.5	-1.4	-1.4	-2.6	-2.0	-1.9	-1.4
Asthma (self-reported)	2.1	4.1	6.9	0.3	0.7	-2.6	-1.8	-1.2	-2.6	-1.9	-2.1	-2.6	-0.9	-2.3	-2.5	-2.6
Illnesses of father: Heart disease	2.0	2.8	7.6	1.7	2.8	-1.6	-1.0	-1.2	-1.2	0.3	-0.4	-1.2	-2.7	-2.4	-2.0	-1.2
Medication: Gliclazide	2.0	2.3	5.5	-1.7	0.7	-1.1	-0.9	-2.2	-1.1	-2.4	-2.1	-1.1	-1.0	-1.6	-1.3	-1.1
Cholesterol lowering medication	2.0	3.0	7.3	2.0	2.1	1.9	1.0	1.6	1.7	2.7	1.4	1.7	0.4	1.0	2.0	1.7
Lung FEV1/FVC ratio	1.9	9.4	24.9	-5.0	-3.6	3.3	2.7	1.5	3.1	-0.5	2.1	3.1	2.0	4.0	3.3	3.1
Exposure to tobacco smoke at home	1.8	2.0	3.1	-0.3	-0.8	1.7	1.4	1.4	1.6	0.8	1.1	1.6	1.7	1.8	1.7	1.6
Medication: Allopurinol	1.8	2.5	5.7	1.2	1.8	-1.5	-1.3	-2.4	-1.1	-0.4	-1.6	-1.1	-1.9	-1.9	-2.0	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.9	0.1	0.9	1.8	1.5	0.8	2.0	1.3	0.8	2.0	1.8	1.3	1.3	2.0
Smoking status: Current	1.8	2.8	7.8	-2.8	-1.1	2.0	0.9	0.1	1.8	-0.2	1.0	1.8	2.1	1.8	2.0	1.8
Vitamin and mineral supplements	1.7	2.4	7.1	-0.0	-0.3	1.7	0.6	2.7	1.4	1.5	2.2	1.4	0.7	1.8	2.1	1.4
Fed-up feelings	1.7	3.1	4.8	0.9	0.5	1.9	2.1	2.0	2.1	2.2	1.9	2.1	1.2	1.7	1.6	2.1
Taking other prescription medications	1.7	2.7	11.6	3.3	3.4	-0.9	-1.1	-0.5	-0.6	1.2	-1.1	-0.6	-1.1	-1.9	-1.4	-0.6
Medication: Cholesterol lowering	1.7	2.6	5.5	2.1	1.9	-1.7	-0.9	-0.0	-1.7	-0.1	-1.1	-1.7	-2.1	-2.3	-1.6	-1.7
Eye problems/disorders: None of the above	1.7	1.9	10.2	-2.6	-3.2	0.9	-0.2	0.3	0.6	-1.1	-0.1	0.6	1.2	1.6	1.1	0.6
Family relationship satisfaction	1.7	2.1	4.6	0.4	0.1	-1.7	-1.4	-1.3	-1.7	-1.4	-1.0	-1.7	-2.1	-1.5	-1.5	-1.7
Supplements: Fish oil (including cod liver oil)	1.7	2.2	5.7	-1.5	-1.1	-1.5	-0.4	-2.4	-1.2	-1.8	-1.7	-1.2	-0.9	-1.5	-2.0	-1.2
LDL Cholesterol	1.6	2.6	5.2	1.1	1.4	1.8	1.5	1.5	1.8	2.3	2.1	1.8	0.1	1.3	1.4	1.8
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	4.6	1.5	0.1	-2.0	-1.9	-1.1	-2.2	-0.2	-0.7	-2.2	-1.5	-1.8	-1.6	-2.2
Osteoarthritis (self-reported)	1.6	2.1	4.4	1.9	2.0	-1.3	-0.6	-2.1	-0.8	0.1	-1.5	-0.8	-0.1	-2.0	-2.1	-0.8
Ever taken oral contraceptive pill	1.6	1.8	2.4	0.2	1.3	-1.4	-1.4	-1.4	-1.5	-1.4	-1.2	-1.5	-1.5	-1.5	-1.1	-1.5
Alcohol drinker status: Never	1.6	1.9	4.2	0.4	-1.4	1.0	2.0	1.8	1.1	1.5	1.4	1.1	1.8	1.3	1.0	1.1
Bipolar Disorder (2018)	1.5	2.4	4.2	0.8	1.2	2.0	1.4	1.0	2.0	1.6	0.8	2.0	1.1	1.4	1.8	2.0
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.9	0.3	-0.3	-1.8	-1.1	-2.0	-1.7	-0.8	-1.2	-1.7	-0.1	-1.8	-1.7	-1.7
Qualifications: None of the above	1.5	3.1	5.9	0.2	-0.1	1.9	2.4	0.7	2.3	1.7	1.5	2.3	2.0	2.0	1.4	2.3
Asthma	1.5	3.0	5.0	0.3	0.8	-2.2	-1.6	-0.9	-2.2	-1.7	-1.9	-2.2	-0.8	-2.0	-2.0	-2.2
Heart disease (siblings)	1.5	1.8	4.1	1.6	1.2	-1.5	-1.1	-1.6	-1.1	0.1	-0.9	-1.1	-1.5	-1.7	-2.0	-1.1
Allergy or Eczema	1.4	3.6	6.8	0.0	-0.3	-2.4	-1.7	-0.9	-2.3	-1.8	-1.9	-2.3	-1.9	-2.2	-2.6	-2.3
Hand grip strength (left)	1.4	3.6	7.0	-0.9	-0.6	2.0	2.4	2.1	2.0	1.4	1.6	2.0	2.6	2.0	2.0	2.0
Hearing difficulty/problems: Yes	1.4	2.1	10.9	-1.5	-1.1	1.0	2.0	0.8	1.2	0.2	0.7	1.2	3.3	1.2	0.7	1.2
Current tobacco smoking	1.4	2.2	6.6	-2.6	-0.9	1.7	0.9	-0.1	1.6	-0.1	1.1	1.6	1.8	1.5	1.9	1.6
Peak expiratory flow (PEF)	1.4	3.3	9.6	-2.3	0.6	1.9	2.3	1.0	1.8	0.3	1.2	1.8	3.1	1.7	1.9	1.8
Smoking status: Previous	1.4	2.1	4.2	2.0	0.1	-1.8	-1.1	-1.3	-1.7	-0.1	-1.6	-1.7	-0.1	-1.6	-1.8	-1.7
Eye problems/disorders: Cataract	1.4	1.6	3.8	0.9	1.4	-1.6	-0.8	-1.1	-1.2	-0.2	-0.4	-1.2	-1.4	-1.9	-1.9	-1.2
Guilty feelings	1.4	2.0	5.7	2.1	1.9	1.3	0.5	0.6	1.3	2.4	1.7	1.3	-0.4	0.8	1.2	1.3
Pack years of smoking	1.4	2.1	4.2	-0.8	-0.4	1.8	1.5	0.9	2.0	0.7	1.1	2.0	1.2	1.9	1.2	2.0
Verbal and Numeric Reasoning (VNR)	1.3	3.0	5.7	1.9	0.2	-2.3	-1.0	-1.6	-2.0	-0.5	-1.4	-2.0	-1.5	-2.0	-2.4	-2.0
Neuroticism	1.3	3.1	8.1	2.0	1.3	1.8	1.5	1.4	1.8	2.8	2.0	1.8	-0.5	1.2	1.8	1.8
Medication: Atenolol	1.3	1.7	8.8	2.8	3.0	-0.1	0.3	0.5	-0.1	1.7	0.3	-0.1	-1.0	-0.9	-0.1	-0.1
Supplements: Vitamin C	1.3	1.6	2.1	-0.2	0.8	-1.3	-1.4	-1.3	-1.5	-1.4	-1.4	-1.5	-1.1	-1.4	-1.1	-1.5
Medication for cholesterol	1.3	2.0	3.8	-1.0	-1.5	-1.7	-1.1	-1.5	-1.6	-2.0	-1.2	-1.6	0.1	-0.9	-1.6	-1.6
Ovarian Cancer	1.2	1.5	5.1	-1.2	-0.1	-1.0	-0.9	-0.6	-1.2	-2.2	-2.3	-1.2	-0.5	-1.1	-0.8	-1.2
Primary Biliary Cirrhosis	1.2	1.7	6.5	-2.2	-0.9	-0.8	-1.0	-1.4	-0.8	-2.5	-1.8	-0.8	0.5	-0.4	-0.9	-0.8
Allergy	1.2	2.7	4.4	-0.4	-0.5	2.1	1.6	0.9	2.1	1.4	1.7	2.1	0.9	2.0	2.1	2.1
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	6.6	-1.8	-2.0	1.1	1.1	-0.1	1.1	-0.1	0.8	1.1	2.6	1.9	1.1	1.1
Shortness of breath walking on level ground	1.2	1.5	2.9	1.2	0.5	-1.5	-1.2	-1.5	-1.3	-0.5	-1.1	-1.3	-0.6	-1.2	-1.7	-1.3
Commuting to job workplace: Walk	1.2	1.3	2.9	-1.3	-0.8	-1.1	-0.6	-1.1	-1.2	-1.7	-1.1	-1.2	1.1	-0.9	-0.9	-1.2
High cholesterol (Self-reported)	1.2	2.1	10.1	3.2	2.6	0.2	0.2	0.9	0.0	2.4	1.0	0.0	-1.5	-0.6	0.5	0.0
HbA1C	1.1	1.2	2.9	-0.3	-0.4	-1.4	-1.7	0.4	-1.4	-1.3	-1.1	-1.4	0.2	-1.0	-0.9	-1.4
Stomach or abdominal pain in last month	1.1	1.4	2.9	1.5	1.2	1.0	1.0	1.3	1.1	1.7	1.6	1.1	0.7	0.6	1.0	1.1
Pain all over the body in last month	1.1	1.2	2.2	-0.8	0.6	1.3	1.4	0.7	1.3	0.4	0.9	1.3	1.5	0.8	1.1	1.3
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.6	0.7	1.0	-1.4	-1.4	0.1	-1.5	-0.8	-1.1	-1.5	-1.1	-1.6	-1.2	-1.5
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.6	0.1	0.3	1.5	0.8	1.0	1.5	1.1	1.6	1.5	-0.6	1.4	1.5	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.9	0.7	1.3	1.2	1.2	1.1	1.1	1.7	1.7	1.1	0.1	0.8	1.6	1.1
Qualifications: College or University degree	1.1	3.4	5.0	-0.4	-0.3	-2.2	-2.0	-1.3	-2.2	-2.0	-1.4	-2.2	-2.0	-2.1	-2.1	-2.2
Mouth/teeth dental problems: Loose teeth	1.1	1.4	2.5	-0.7	-1.1	1.2	1.6	0.9	0.9	0.5	1.2	0.9	1.6	1.5	1.6	0.9
Knee pain experienced in last month	1.1	1.7	3.5	1.9	1.2	-1.5	-1.5	-0.5	-1.3	-0.3	-1.3	-1.3	-0.7	-1.5	-1.5	-1.3
Long-standing illness, disability or infirmity	1.1	1.6	3.2	1.8	1.4	-1.3	-1.0	-0.7	-1.4	-0.0	-1.6	-1.4	-0.1	-1.8	-1.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	4.9	-1.1	0.1	1.7	1.5	0.5	2.0	1.3	2.2	2.0	0.4	1.5	1.3	2.0
Number of self-reported non-cancer illnesses	1.1	1.8	9.8	3.1	2.5	-0.6	0.0	0.2	-0.5	1.5	-0.4	-0.5	-1.3	-1.4	-0.7	-0.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.3	-1.0	-1.5	1.1	1.0	1.2	1.0	0.7	1.5	1.0	0.2	1.5	1.3	1.0
Neuroticism (Nagel 2018)	1.0	2.3	6.9	1.8	0.7	1.4	1.5	1.1	1.6	2.6	1.6	1.6	-0.8	1.1	1.1	1.6
Coronary Artery Disease (CAD)	1.0	1.2	6.9	2.0	2.6	-0.3	0.2	-0.4	0.0	1.3	-0.0	0.0	-0.9	-0.9	-0.8	0.0
Number of treatments/medications taken	1.0	1.8	6.0	2.5	2.4	-0.8	-0.9	-1.1	-0.4	0.8	-1.1	-0.4	-1.5	-1.7	-1.3	-0.4
Hayfever, allergic rhinitis or eczema	1.0	2.2	3.8	0.5	-0.1	-1.9	-1.4	-0.2	-1.9	-1.3	-1.7	-1.9	-1.0	-1.8	-1.7	-1.9
Sitting height	1.0	6.9	21.3	-4.1	-2.8	2.3	2.3	1.7	2.1	-0.6	1.4	2.1	4.6	3.0	2.4	2.1
Neuroticism score	1.0	2.0	4.1	1.0	1.2	1.6	1.2	1.3	1.6	2.0	1.5	1.6	-0.5	1.1	1.7	1.6
Impedance of arm (left)	1.0	4.6	25.3	-2.9	-5.0	-0.9	-1.4	-2.7	-1.0	-2.7	-1.5	-1.0	-1.5	0.5	-0.7	-1.0
Number of full sisters	1.0	1.2	3.6	0.4	0.1	-1.3	-0.3	-1.1	-1.4	-1.2	-1.9	-1.4	-0.2	-1.1	-1.0	-1.4
Overall health rating	1.0	2.2	3.2	0.6	0.2	1.8	1.8	1.2	1.7	1.7	1.6	1.7	0.1	1.7	1.7	1.7
Mother’s age at death	1.0	1.3	3.5	0.4	-1.5	-1.4	-0.4	-1.4	-1.0	-0.6	-0.8	-1.0	-1.2	-1.0	-1.9	-1.0
Commuting to job workplace: Public transport	1.0	1.2	3.1	-0.3	-0.6	1.1	1.3	1.8	0.8	0.8	1.3	0.8	1.5	1.2	1.4	0.8
Medication: Blood pressure	1.0	2.0	3.6	0.4	1.1	1.7	1.7	0.9	1.8	1.9	1.5	1.8	0.2	0.8	1.3	1.8
Medication: Lisinopril	1.0	1.3	3.0	1.5	1.6	-0.9	-1.4	-0.5	-1.0	-0.0	-1.7	-1.0	-0.9	-1.3	-0.9	-1.0
Medication: Atorvastatin	1.0	1.2	4.9	1.1	2.2	-0.5	-0.6	-0.0	-0.7	0.0	-0.8	-0.7	-2.2	-1.4	-0.3	-0.7
Impedance of whole body	1.0	5.0	25.2	-3.4	-5.0	-0.9	-1.6	-2.7	-1.1	-2.9	-1.5	-1.1	-1.8	0.4	-0.6	-1.1
Depressed Affect (Nagel 2018)	0.9	1.8	5.4	1.7	0.3	1.3	0.9	1.2	1.3	2.3	1.7	1.3	-1.0	1.1	1.2	1.3
Worry (Nagel 2018)	0.9	2.0	4.7	1.0	0.5	1.5	1.9	0.1	1.8	2.2	1.4	1.8	-0.2	1.1	1.2	1.8
Lupus	0.9	1.3	6.8	-2.3	-1.0	0.6	0.5	0.6	0.6	-1.1	-0.1	0.6	2.6	0.8	0.5	0.6
Ever had hysterectomy (womb removed)	0.9	1.0	3.1	-0.6	0.2	1.3	0.5	1.8	1.0	0.3	0.6	1.0	0.7	1.3	1.4	1.0
Systolic blood pressure, automated reading	0.9	2.7	11.0	3.2	0.7	1.0	0.6	1.7	1.1	3.3	1.8	1.1	-1.0	0.3	0.8	1.1
Diabetes (father)	0.9	1.1	6.7	-0.6	-1.7	0.4	1.1	0.3	0.7	0.1	-0.2	0.7	2.6	0.9	0.0	0.7
Impedance of leg (left)	0.9	4.4	15.0	-3.2	-3.9	-1.2	-1.6	-2.9	-1.4	-2.7	-1.5	-1.4	-1.9	-0.2	-0.8	-1.4
Medication: Simvastatin	0.9	1.4	7.3	1.8	2.7	-0.8	-0.3	-0.5	-0.8	0.3	-1.0	-0.8	-0.1	-1.5	-1.0	-0.8
Impedance of arm (right)	0.9	4.1	26.9	-3.3	-5.2	-0.4	-0.9	-1.9	-0.5	-2.6	-1.1	-0.5	-0.6	1.0	-0.3	-0.5
Hair/balding pattern: Pattern 3	0.9	1.4	5.2	2.3	1.5	0.4	-0.5	1.6	0.5	2.0	1.7	0.5	-0.4	-0.1	0.4	0.5
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	6.1	-2.5	0.8	1.9	2.0	1.3	1.7	0.4	1.7	1.7	2.0	1.7	2.0	1.7
Medication: Amlodipine	0.9	1.3	2.8	-1.2	-0.3	1.4	1.1	0.8	1.7	0.4	0.8	1.7	0.4	1.1	0.8	1.7
Medication: Blood pressure	0.9	1.7	7.1	2.4	2.7	-0.3	-0.8	0.5	-0.3	0.9	-0.3	-0.3	-2.3	-1.1	-0.3	-0.3
Mean time to correctly identify matches	0.9	1.8	6.5	2.1	1.6	-1.1	-1.3	-0.7	-0.9	0.7	0.2	-0.9	-2.5	-1.5	-1.1	-0.9
Had major operations	0.9	1.1	2.2	-0.4	0.1	-1.2	-0.1	-0.4	-1.3	-1.5	-1.3	-1.3	0.0	-1.3	-1.1	-1.3
Leg pain on walking	0.9	1.1	2.9	-1.2	-1.7	0.7	1.5	-0.7	1.1	0.3	1.0	1.1	0.7	1.0	0.4	1.1
Illnesses of father: None of the above (group 1)	0.9	1.1	3.7	-1.4	-1.9	0.9	0.8	0.6	0.8	-0.3	0.9	0.8	0.2	1.6	1.2	0.8
Alzheimer’s Disease (including proxy)	0.8	1.2	2.2	-1.0	-1.5	1.2	1.3	0.8	1.2	0.3	0.9	1.2	0.3	1.4	1.1	1.2
Systolic Blood Pressure	0.8	3.8	16.5	3.9	1.8	1.0	1.4	1.5	1.2	4.1	2.0	1.2	-0.7	-0.2	0.6	1.2
Respiratory disease	0.8	1.8	3.5	0.7	0.1	-1.9	-0.9	-0.5	-1.8	-1.0	-1.4	-1.8	-0.4	-1.4	-1.9	-1.8
Supplements: Zinc	0.8	0.9	3.5	0.3	0.3	-0.8	-0.9	-1.3	-0.7	-0.9	-1.9	-0.7	0.7	-0.8	-1.0	-0.7
Mouth/teeth dental problems	0.8	1.3	3.3	1.3	1.8	-1.1	-0.9	-0.4	-1.2	-0.0	-0.8	-1.2	-0.9	-1.6	-1.0	-1.2
Time employed in main current job	0.8	0.9	1.6	1.1	0.6	0.8	0.9	1.3	0.6	1.2	1.0	0.6	-1.1	0.9	1.2	0.6
Happiness	0.8	1.0	2.7	-1.3	-1.4	-0.9	-0.8	-0.9	-0.8	-1.6	-0.9	-0.8	-0.8	-0.6	-1.2	-0.8
Depression (self-reported)	0.8	0.9	2.8	1.7	1.6	0.5	0.5	0.8	0.4	1.5	1.2	0.4	-0.8	0.1	1.0	0.4
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.7	-0.6	-1.9	0.9	0.7	-0.3	1.0	0.7	1.0	1.0	0.1	1.3	0.9	1.0
Chronic bronchitis/emphysema (mother)	0.8	0.9	4.1	0.5	0.5	-0.9	-2.0	0.6	-1.0	-0.7	-1.0	-1.0	-0.4	-1.1	-0.7	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.0	1.1	1.4	0.9	0.3	1.2	0.7	1.4	0.7	0.7	0.9	0.5	0.9	0.7
Hypertension (Self-reported)	0.8	2.2	5.1	2.0	1.8	1.4	1.3	1.7	1.3	2.3	1.2	1.3	-0.7	0.5	1.4	1.3
Friendships satisfaction	0.8	1.0	2.4	-0.4	-0.6	-1.1	-1.2	-0.6	-1.1	-1.3	-0.7	-1.1	-1.5	-0.8	-1.2	-1.1
Osteoporosis (self-reported)	0.8	1.0	3.7	-1.0	0.3	-0.8	-0.5	-1.9	-0.5	-1.3	-1.5	-0.5	0.6	-0.8	-1.3	-0.5
Type 2 Diabetes (T2D) (2018)	0.7	1.4	6.1	-2.5	0.2	0.3	0.9	-0.3	0.0	-1.9	-1.8	0.0	1.9	-0.1	0.3	0.0
Average weekly spirits intake	0.7	0.8	1.5	-1.0	-1.1	0.9	1.2	-0.3	1.1	0.3	0.6	1.1	0.6	1.1	0.6	1.1
Serious illness, injury or assault to yourself	0.7	0.9	2.9	-1.2	0.2	0.9	1.0	1.7	0.7	-0.4	0.7	0.7	0.9	0.9	1.3	0.7
High blood pressure	0.7	2.0	5.2	2.3	2.3	1.2	1.0	1.8	0.9	2.0	0.9	0.9	-1.0	0.2	1.3	0.9
Multivitamins +/- minerals	0.7	0.9	3.4	0.9	0.4	-1.1	0.1	-1.9	-0.8	-0.3	-1.0	-0.8	-0.7	-1.1	-1.2	-0.8
Chronic bronchitis/emphysema (father)	0.7	0.8	2.9	0.1	0.9	-0.6	-1.3	-1.5	-0.5	-0.4	-0.6	-0.5	-1.7	-0.8	-0.7	-0.5
Worrier / anxious feelings	0.7	1.3	4.8	0.2	-0.5	1.2	2.2	0.8	1.2	1.2	0.9	1.2	0.4	1.1	1.2	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	4.7	-2.2	-1.3	0.5	0.2	-0.7	0.7	-1.3	-0.3	0.7	0.6	0.9	0.1	0.7
Glaucoma (self-reported)	0.7	0.9	3.6	1.2	0.6	0.7	1.1	0.3	0.6	1.1	0.8	0.6	-1.9	0.5	0.9	0.6
Number of full brothers	0.7	0.9	4.1	-2.0	-0.9	-0.2	-0.4	-0.5	-0.5	-1.9	-1.1	-0.5	0.4	0.0	-0.0	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.4	-1.8	-1.2	-0.2	-0.1	-0.9	-0.2	-1.5	-0.5	-0.2	-1.4	-0.1	-0.3	-0.2
Number of operations (self-reported)	0.7	1.1	3.1	0.0	0.3	-1.0	-1.3	-1.0	-1.1	-1.1	-1.7	-1.1	-0.2	-1.2	-0.9	-1.1
Diastolic blood pressure, automated reading	0.7	2.0	11.6	3.4	2.1	-0.2	-0.7	1.1	-0.3	2.3	0.5	-0.3	-1.4	-1.1	-0.2	-0.3
Unable to work because of sickness or disability	0.7	0.9	2.7	-0.7	-0.3	1.0	1.2	0.7	0.8	0.5	0.9	0.8	1.6	0.9	1.3	0.8
Basal cell carcinoma (self-reported)	0.7	0.9	3.6	-1.9	-1.5	0.7	0.9	-0.2	0.6	-0.6	0.3	0.6	0.9	1.0	0.9	0.6
Schizophrenia vs Biploar Disorder	0.6	0.8	4.0	-2.0	-1.6	-0.2	0.2	-0.0	-0.4	-1.6	-0.6	-0.4	0.5	0.2	0.1	-0.4
Breast Cancer	0.6	1.4	5.1	-2.3	-2.0	-0.9	0.3	-1.2	-0.7	-2.0	-0.7	-0.7	-0.4	-0.3	-1.0	-0.7
Body Mass Index (BMI) (2010)	0.6	0.8	1.4	-0.0	0.8	1.1	0.8	1.0	0.9	0.7	0.9	0.9	1.2	0.7	1.1	0.9
HDL Cholesterol	0.6	1.0	6.9	2.6	0.5	-0.0	-0.2	1.0	-0.1	1.8	0.7	-0.1	-1.2	0.1	0.4	-0.1
Ulcerative Colitis	0.6	0.9	8.5	1.3	2.9	0.1	-0.1	0.7	0.3	0.9	0.1	0.3	0.2	-0.6	-0.2	0.3
Heel T-Score	0.6	4.4	20.5	-0.6	-4.5	-1.7	-2.0	-1.4	-1.5	-2.4	-1.7	-1.5	-3.0	0.5	-1.6	-1.5
Tanning	0.6	6.7	18.5	-3.8	-2.2	-2.3	-2.0	-0.8	-2.6	-4.3	-3.2	-2.6	1.4	-1.9	-2.1	-2.6
Relative age of first facial hair	0.6	1.1	3.5	-0.5	0.1	-0.8	-1.4	-0.6	-1.1	-1.3	-1.4	-1.1	-1.9	-1.0	-0.6	-1.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.5	0.1	0.0	-0.9	-0.2	-0.4	-1.0	-0.9	-1.6	-1.0	0.3	-0.7	-0.8	-1.0
Impedance of leg (right)	0.6	3.0	9.1	-2.9	-3.0	-0.8	-1.0	-2.7	-1.0	-2.3	-0.9	-1.0	-1.9	-0.1	-0.6	-1.0
Leg fat-free mass (left)	0.6	3.2	10.4	-0.4	2.1	1.7	2.1	2.6	1.4	0.5	0.7	1.4	3.2	1.4	1.8	1.4
Leg predicted mass (left)	0.6	3.1	10.3	-0.4	2.2	1.6	2.1	2.6	1.4	0.5	0.6	1.4	3.2	1.3	1.8	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.0	1.1	0.5	0.9	1.4	1.0	0.9	1.4	1.0	0.9	0.7	0.8	0.9	0.9
Diabetes (self-reported)	0.6	0.9	3.6	-1.8	-0.1	0.4	0.9	0.7	0.2	-1.4	-1.1	0.2	1.9	0.4	0.4	0.2
Fluid intelligence score	0.6	1.2	3.3	1.0	-0.6	-1.6	-0.2	-1.2	-1.2	-0.4	-0.9	-1.2	-0.5	-1.3	-1.8	-1.2
Trunk fat-free mass	0.6	3.2	11.7	-0.6	3.0	1.4	1.9	2.4	1.3	0.8	1.1	1.3	3.4	0.8	1.4	1.3
Alcohol intake versus 10 years previously	0.6	0.8	1.3	1.0	1.1	1.1	0.7	0.4	1.0	1.1	0.6	1.0	0.4	0.9	1.0	1.0
Falls in the last year	0.6	0.8	1.7	0.8	0.4	-0.9	-1.3	0.6	-1.1	-0.6	-1.0	-1.1	0.1	-1.0	-0.5	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	5.5	2.3	0.9	-0.5	0.2	-0.3	-0.6	1.1	-0.2	-0.6	-0.3	-0.5	-0.1	-0.6
Trunk predicted mass	0.6	3.2	11.2	-0.6	3.1	1.4	1.9	2.4	1.3	0.8	1.1	1.3	3.3	0.7	1.4	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.4	1.8	1.7	-0.8	-0.3	-0.5	-0.7	0.7	-0.1	-0.7	-1.1	-1.1	-0.7	-0.7
Arm fat-free mass (right)	0.6	3.1	8.5	-0.2	2.8	1.6	1.9	2.5	1.4	0.9	0.9	1.4	2.9	1.0	1.7	1.4
Medication: Ibuprofen	0.6	0.7	3.6	-1.9	-1.0	0.6	-0.2	-0.6	0.7	-1.0	-0.1	0.7	0.6	0.8	0.3	0.7
Chest pain or discomfort	0.6	0.9	1.6	1.3	0.3	-0.9	-1.1	0.1	-1.2	-0.1	-1.1	-1.2	-0.6	-1.2	-0.5	-1.2
Whole body fat-free mass	0.6	3.2	11.6	-0.6	2.7	1.5	2.0	2.5	1.3	0.6	0.9	1.3	3.4	1.0	1.6	1.3
Diabetes diagnosed by doctor	0.6	1.0	3.8	-1.9	-0.1	0.1	0.4	-0.0	-0.1	-1.8	-1.7	-0.1	1.6	-0.1	0.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.7	1.5	1.6	-0.6	-0.8	-0.4	-0.4	0.5	-0.5	-0.4	-0.7	-0.8	-0.7	-0.4
Whole body water mass	0.6	3.7	12.2	-0.5	2.7	1.7	2.2	2.7	1.5	0.8	1.1	1.5	3.5	1.2	1.7	1.5
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.9	0.2	-0.2	-0.8	-1.1	-1.0	-0.8	-0.7	-0.8	-0.8	-1.7	-0.6	-0.6	-0.8
Medication: Bendroflumethiazide	0.6	0.9	2.5	1.2	1.1	1.0	1.1	0.7	1.0	1.6	0.7	1.0	-0.0	0.2	0.9	1.0
Arm fat-free mass (left)	0.6	3.0	7.7	-0.5	2.6	1.5	2.0	2.7	1.3	0.7	1.1	1.3	2.8	1.0	1.6	1.3
Vascular/heart problems diagnosed by doctor	0.6	1.7	6.5	-2.2	-2.5	-0.9	-0.7	-1.7	-0.8	-1.8	-0.5	-0.8	0.9	0.1	-0.9	-0.8
Supplements: Calcium	0.6	0.6	5.2	-0.6	-0.2	-0.4	-0.1	-2.3	0.0	-0.2	-0.9	0.0	0.7	-0.5	-1.0	0.0
Alzheimer’s Disease (in mother)	0.5	0.6	2.5	-1.6	-1.5	0.3	0.7	0.6	0.4	-0.7	0.6	0.4	-0.4	0.8	0.3	0.4
Reaction Time	0.5	1.0	3.7	1.7	1.9	-0.5	-0.9	-0.6	-0.5	0.9	0.6	-0.5	-1.6	-0.9	-0.5	-0.5
Rheumatoid Arthritis	0.5	0.7	2.4	0.9	1.5	0.6	0.9	1.2	0.6	0.9	0.7	0.6	0.8	0.4	0.6	0.6
Waist Hip Ratio (WHR)	0.5	2.4	6.8	-2.4	-1.7	-0.9	-1.1	-2.5	-0.8	-2.6	-2.0	-0.8	-0.9	-0.1	-1.0	-0.8
Cardiovascular Disease	0.5	1.7	6.5	2.5	2.4	0.7	0.9	1.5	0.6	2.2	0.3	0.6	-0.1	-0.3	0.6	0.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.7	1.7	1.1	0.4	-0.3	0.8	0.3	1.4	0.9	0.3	-1.1	0.1	0.6	0.3
Average weekly fortified wine intake	0.5	0.5	2.0	1.4	1.2	-0.1	0.5	-0.0	0.1	1.0	0.4	0.1	1.3	-0.2	-0.3	0.1
Past tobacco smoking	0.5	0.9	2.3	-0.5	0.3	1.1	0.8	1.5	1.0	0.3	1.2	1.0	-0.6	1.1	1.2	1.0
Forced vital capacity (FVC)	0.5	1.9	4.0	-1.5	1.7	1.4	1.7	0.9	1.3	0.7	1.2	1.3	2.0	0.9	1.4	1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	2.6	0.4	0.4	0.6	0.6	0.2	0.9	1.5	1.6	0.9	0.2	0.5	0.3	0.9
Financial difficulties in last 2 years	0.5	0.7	1.7	-0.2	-0.3	0.8	1.3	-0.2	1.0	0.5	0.3	1.0	1.3	0.8	0.4	1.0
Heart attack	0.5	0.6	2.3	0.8	0.8	-0.6	-0.3	0.5	-0.6	-0.5	-0.9	-0.6	-1.5	-0.9	-0.8	-0.6
Medication: Lansoprazole	0.5	0.5	2.2	1.0	1.5	0.3	0.5	-0.1	0.5	0.6	-0.5	0.5	1.5	-0.2	0.1	0.5
Breastfed as a baby	0.5	0.6	2.4	1.1	0.8	0.4	-0.3	-0.6	0.3	1.2	0.7	0.3	-1.6	-0.1	0.5	0.3
Loud music exposure frequency	0.5	0.5	2.4	-0.2	0.3	0.7	1.1	0.2	0.7	0.5	0.3	0.7	1.6	0.8	0.6	0.7
Number of children fathered	0.5	0.6	3.3	-1.8	-1.6	-0.1	-0.0	-0.7	0.1	-0.9	0.2	0.1	-0.1	0.7	-0.3	0.1
Health satisfaction	0.5	0.7	3.2	-1.8	-1.2	-0.0	0.7	-1.1	0.2	-1.1	-0.6	0.2	1.1	0.0	-0.2	0.2
Emphysema/chronic bronchitis	0.5	0.6	2.3	-0.0	-0.1	0.7	0.5	1.2	0.6	0.6	0.9	0.6	1.5	0.5	0.9	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.5	0.1	-0.6	1.1	-0.3	0.3	0.9	0.7	0.5	0.9	0.4	1.2	1.1	0.9
Arm predicted mass (right)	0.5	2.3	8.4	-0.2	2.9	1.2	1.6	2.2	1.0	0.6	0.7	1.0	2.6	0.6	1.3	1.0
Pulse rate, automated reading	0.5	1.5	9.5	3.1	1.1	-0.9	0.7	0.3	-0.8	1.4	-0.6	-0.8	0.8	-1.3	-0.9	-0.8
Leg fat-free mass (right)	0.5	2.8	12.0	-0.5	1.6	1.5	1.8	2.5	1.2	0.4	0.5	1.2	3.5	1.4	1.7	1.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.0	0.1	0.3	0.7	0.6	0.4	0.9	1.3	1.4	0.9	-0.3	0.4	0.5	0.9
Mood swings	0.5	0.9	4.3	2.1	1.2	0.4	0.1	0.2	0.4	1.9	0.6	0.4	-0.9	0.0	0.6	0.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	3.2	-1.8	-0.7	0.7	1.1	0.4	0.7	-0.8	-0.2	0.7	0.8	1.0	0.7	0.7
Breast cancer (self-reported)	0.5	0.6	1.2	-0.6	-1.1	0.8	0.7	0.5	0.8	0.5	0.7	0.8	0.8	0.9	0.8	0.8
Leg predicted mass (right)	0.5	2.7	11.6	-0.4	1.7	1.5	1.8	2.5	1.2	0.4	0.5	1.2	3.4	1.3	1.7	1.2
Eye problems/disorders: Glaucoma	0.5	0.6	2.2	1.2	0.8	0.6	1.1	0.3	0.4	1.0	0.4	0.4	-1.5	0.4	0.8	0.4
Basal metabolic rate	0.5	3.0	9.5	-0.7	2.3	1.5	2.0	2.5	1.3	0.4	0.8	1.3	3.1	1.2	1.6	1.3
Average weekly beer plus cider intake	0.5	0.7	3.8	0.9	1.9	0.7	-1.0	0.1	0.4	0.5	-1.1	0.4	-0.7	-0.2	0.8	0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.3	1.0	0.7	-0.7	-0.4	0.4	-0.6	-0.4	-1.0	-0.6	-1.5	-1.0	-1.0	-0.6
Arm predicted mass (left)	0.5	2.8	7.9	-0.5	2.8	1.3	1.9	2.7	1.1	0.5	0.8	1.1	2.8	0.8	1.5	1.1
Crohns Disease (2012)	0.4	0.7	3.7	-1.1	-1.9	0.3	0.8	-0.1	0.5	-0.4	-0.6	0.5	0.6	1.1	0.1	0.5
Triglycerides	0.4	0.7	2.3	0.4	0.3	0.8	0.7	0.7	0.8	1.0	1.5	0.8	0.0	0.9	0.8	0.8
BMI	0.4	2.5	5.4	0.1	2.0	1.7	2.3	1.9	1.7	0.7	0.6	1.7	1.6	1.4	1.7	1.7
Lung FVC	0.4	1.9	8.4	1.5	2.9	-1.3	-0.6	-0.2	-1.3	0.5	-0.2	-1.3	-1.1	-2.1	-1.2	-1.3
Medication: Co-codamol	0.4	0.5	1.7	0.3	-0.3	-0.8	-0.9	-0.8	-0.4	-0.3	-1.1	-0.4	0.0	-1.0	-1.3	-0.4
Hand grip strength (right)	0.4	1.2	2.6	0.6	0.4	1.1	1.2	1.6	0.9	1.3	1.2	0.9	1.1	0.9	1.4	0.9
Townsend deprivation index at recruitment	0.4	0.5	2.3	0.6	1.1	0.3	0.7	-0.7	0.5	0.9	-0.2	0.5	1.5	-0.3	0.0	0.5
Alcohol usually taken with meals	0.4	0.7	3.3	1.8	1.4	-0.6	0.0	-0.0	-0.6	0.9	0.6	-0.6	-0.7	-0.7	-0.4	-0.6
Hearing difficulty/problems with background noise	0.4	0.6	1.4	-0.8	0.0	0.7	1.1	-0.2	1.2	0.5	1.0	1.2	0.4	0.4	-0.1	1.2
Father’s age at death	0.4	0.6	2.0	1.2	-1.4	-0.9	-0.8	0.3	-0.8	-0.1	-0.5	-0.8	-0.1	-0.1	-0.8	-0.8
Lung cancer (father)	0.4	0.5	1.9	-0.6	0.5	-0.3	-0.8	-0.6	-0.4	-1.3	-1.4	-0.4	-0.2	-0.2	-0.0	-0.4
Pulse wave Arterial Stiffness index	0.4	0.5	1.7	0.7	-0.2	0.8	0.1	0.6	0.7	1.3	0.6	0.7	-0.2	0.6	0.8	0.7
Standing height	0.4	3.5	16.6	-4.1	-1.5	1.2	1.2	0.6	0.9	-1.5	0.0	0.9	3.8	1.6	1.4	0.9
Tense / ‘highly strung’	0.4	0.7	4.5	1.3	2.1	0.2	0.2	-0.5	0.4	0.6	-1.0	0.4	-0.6	-0.5	-0.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.2	-0.5	1.1	-0.9	-0.8	-0.3	-1.1	-1.0	-1.0	-1.1	0.6	-1.0	-0.7	-1.1
Loneliness, isolation	0.4	0.5	0.9	0.9	0.6	0.8	-0.1	0.9	0.7	1.0	0.6	0.7	-0.8	0.7	0.9	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.3	0.0	-1.2	0.5	0.2	1.0	0.5	0.7	-0.0	0.5	1.1	0.8	0.5	0.5
Miserableness	0.4	0.7	3.3	1.8	1.5	0.2	0.3	0.7	0.2	1.2	0.7	0.2	-1.2	0.1	0.2	0.2
Illnesses of father: High blood pressure	0.4	0.5	1.8	1.1	1.4	-0.4	-0.6	0.3	-0.4	0.2	-0.6	-0.4	0.6	-0.8	-0.6	-0.4
Fractured/broken bones in last 5 years	0.4	0.5	2.3	-1.2	-0.4	-0.5	-0.3	0.1	-0.8	-1.5	-0.1	-0.8	0.2	-0.4	-0.2	-0.8
Commuting to job workplace: Cycle	0.4	0.4	1.6	-1.0	-1.3	-0.6	-0.3	-0.7	-0.6	-0.9	-0.1	-0.6	-0.0	-0.2	-0.4	-0.6
Ulcerative Colitis (UC)	0.3	0.6	4.7	0.7	2.2	0.3	0.3	0.9	0.4	0.7	0.6	0.4	0.3	-0.2	0.1	0.4
Blood White Count	0.3	2.5	15.5	2.6	3.9	-0.0	0.4	-0.3	0.4	2.3	0.5	0.4	-1.0	-1.3	-0.6	0.4
Height	0.3	5.3	23.2	-4.8	-1.9	1.1	1.0	1.8	0.5	-2.8	-0.8	0.5	4.7	1.8	1.6	0.5
Smoking Status	0.3	0.6	3.4	-1.0	-1.1	0.6	0.4	-0.4	0.6	-0.0	0.1	0.6	1.9	0.7	0.7	0.6
Medication for hormone replacement therapy	0.3	0.4	1.1	0.0	0.9	0.8	0.0	1.0	0.5	0.0	-0.1	0.5	-0.2	0.6	1.1	0.5
Maternal smoking around birth	0.3	0.5	2.0	-1.3	0.4	0.3	-0.9	-1.4	0.3	-0.7	-0.9	0.3	0.2	-0.0	0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	3.5	-0.1	-1.9	-0.4	-0.5	-0.8	-0.3	-0.7	-0.8	-0.3	-1.3	0.4	-0.4	-0.3
High blood pressure (mother)	0.3	0.4	0.7	-0.8	-0.6	0.7	0.8	-0.2	0.7	0.2	0.7	0.7	-0.7	0.7	0.7	0.7
Had menopause	0.3	0.4	1.2	-1.1	-0.4	0.7	-0.2	0.4	0.7	-0.5	-0.1	0.7	-0.2	0.6	0.5	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	4.6	-0.3	-2.1	-0.2	-0.0	-1.1	-0.2	-0.8	-0.6	-0.2	-1.4	0.5	-0.2	-0.2
Illnesses of siblings	0.3	0.4	1.0	-0.5	0.5	0.8	1.0	0.4	0.5	-0.2	0.3	0.5	0.1	0.8	1.0	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	3.2	0.5	1.1	-0.1	-0.7	-0.9	-0.2	-0.1	-0.1	-0.2	-1.8	-0.4	0.1	-0.2
Pulse rate	0.3	0.5	1.7	0.7	-0.2	-0.7	-0.5	-0.1	-0.6	-0.0	-0.6	-0.6	1.3	-0.8	-0.9	-0.6
Illnesses of mother	0.3	0.4	1.3	0.2	0.9	0.4	0.7	-0.2	0.6	0.8	0.7	0.6	1.1	0.2	0.2	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	3.7	-1.9	0.9	0.6	1.0	0.2	0.7	-0.1	0.7	0.7	1.5	0.6	0.5	0.7
Length of working week for main job	0.3	0.4	1.1	0.1	-0.6	0.7	0.8	0.7	0.5	0.0	-0.1	0.5	0.6	1.1	0.8	0.5
Medication: Paracetamol	0.3	0.4	2.9	0.2	0.2	-0.5	-0.2	-1.7	-0.1	-0.0	0.1	-0.1	-0.8	-0.6	-1.1	-0.1
Wheeze or whistling in the chest in last year	0.3	0.6	1.6	1.2	1.3	-0.6	-0.6	-0.4	-0.3	0.6	0.1	-0.3	0.6	-1.1	-1.1	-0.3
Pulse wave peak to peak time	0.3	0.4	1.8	-1.3	-0.2	-0.4	0.2	-0.4	-0.4	-1.3	-0.4	-0.4	0.6	-0.1	-0.4	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.6	1.5	0.7	0.5	-0.9	-0.6	0.3	-1.2	-0.1	-0.5	-1.2	0.2	-0.8	-0.2	-1.2
Neck or shoulder pain in last month	0.3	0.4	1.7	1.2	1.1	0.0	0.7	0.7	0.1	0.5	-0.2	0.1	1.3	0.0	-0.1	0.1
Migraine (self-reported)	0.3	0.4	1.2	0.6	0.3	0.3	0.9	-0.1	0.6	1.1	1.0	0.6	-0.2	0.0	-0.2	0.6
Age at last live birth	0.3	0.4	0.9	-0.8	-0.1	0.9	0.3	0.3	0.8	0.4	0.3	0.8	0.4	0.7	0.9	0.8
Back pain experienced in last month	0.3	0.4	1.8	0.8	1.3	0.3	-0.6	0.5	0.1	0.4	0.2	0.1	-1.1	-0.2	0.5	0.1
Irritability	0.3	0.4	1.0	0.1	1.0	0.8	0.6	1.0	0.7	0.5	0.6	0.7	0.2	0.4	0.7	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.5	-1.1	-1.2	-0.1	0.1	-0.4	-0.1	-1.2	-1.0	-0.1	-0.1	-0.0	-0.4	-0.1
Pain experienced in last month	0.3	0.4	1.1	-0.1	-0.6	0.6	0.5	0.2	0.7	1.1	0.7	0.7	0.9	0.7	0.4	0.7
Alcohol drinker status: Previous	0.3	0.4	0.9	-0.7	-1.0	-0.6	0.2	-0.9	-0.4	-0.6	-0.5	-0.4	0.9	-0.3	-0.7	-0.4
Crohns Disease (2017)	0.2	0.4	0.8	-0.5	-0.9	-0.8	-0.5	-0.9	-0.7	-0.7	-0.6	-0.7	-0.1	-0.4	-0.7	-0.7
Age at First Birth	0.2	0.3	1.9	0.6	0.5	-0.3	-0.1	-0.3	-0.4	0.1	-0.3	-0.4	-1.4	-0.6	-0.2	-0.4
Neuroticism (2016)	0.2	0.3	0.7	-0.3	-0.8	0.4	0.8	0.8	0.2	0.0	0.4	0.2	0.1	0.8	0.8	0.2
Blood Platelet Count	0.2	2.0	6.1	-0.6	2.5	-1.3	-0.7	0.0	-1.3	-0.9	-1.3	-1.3	-1.0	-2.5	-1.5	-1.3
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.4	0.3	0.5	-0.2	0.7	0.4	-0.3	-0.7	0.4	0.6	0.3	0.6	0.4
Angina	0.2	0.2	0.7	0.4	0.4	-0.5	-0.1	-0.2	-0.2	0.0	-0.6	-0.2	0.7	-0.6	-0.8	-0.2
Medication: Metformin	0.2	0.3	1.0	-0.4	1.0	0.1	0.5	0.6	-0.1	-0.7	-0.7	-0.1	0.9	-0.3	0.2	-0.1
Diabetes (mother)	0.2	0.2	1.1	0.2	-0.4	0.3	0.7	0.7	0.2	0.2	0.1	0.2	1.0	0.5	0.4	0.2
Severe depression (siblings)	0.2	0.2	0.9	0.2	0.2	-0.3	-0.9	0.0	-0.4	-0.2	0.0	-0.4	-0.7	-0.4	-0.3	-0.4
Trunk fat percentage	0.2	0.9	3.3	-1.5	-1.7	0.2	0.4	0.0	0.0	-1.8	-1.2	0.0	-0.6	1.0	0.4	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	0.5	0.4	0.4	0.4	0.8	0.4	0.7	0.9	0.4	-0.3	0.2	0.5	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	-0.6	0.6	0.5	0.3	0.9	0.2	-0.2	-0.1	0.2	0.5	0.4	0.7	0.2
Medication: Levothyroxine sodium	0.2	0.3	1.2	1.1	0.5	0.0	-0.6	0.3	0.1	0.8	0.3	0.1	-0.8	-0.2	-0.2	0.1
Trunk fat mass	0.2	0.8	2.6	-1.6	-0.8	0.7	0.9	0.7	0.5	-1.4	-0.8	0.5	0.5	1.3	0.8	0.5
Nervous feelings	0.2	0.4	1.5	-0.4	1.0	0.4	0.6	-1.2	0.7	0.3	0.3	0.7	-0.4	-0.2	-0.2	0.7
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.2	-0.3	-0.5	0.6	0.3	-0.8	-0.7	-0.6	-0.8	0.3	0.1	-0.0	-0.8
Had other major operations	0.2	0.2	0.7	-0.7	-0.8	-0.0	-0.6	-0.3	-0.0	-0.8	-0.8	-0.0	-0.3	0.2	-0.0	-0.0
Medication: Ramipril	0.2	0.3	1.2	0.3	1.1	0.4	0.6	0.8	0.3	0.5	0.1	0.3	0.1	-0.0	0.6	0.3
Weight	0.2	1.2	2.9	-0.8	1.3	0.9	1.5	1.7	0.8	-0.5	-0.0	0.8	1.7	0.9	0.9	0.8
Arm fat percentage (right)	0.2	0.6	2.0	-0.4	-0.3	0.7	1.4	1.2	0.7	-0.6	-0.2	0.7	-0.1	1.2	0.6	0.7
Hip circumference	0.2	0.7	2.0	-1.2	0.1	0.6	1.4	1.1	0.6	-0.9	-0.0	0.6	1.1	1.1	0.6	0.6
Noisy workplace	0.2	0.2	0.7	0.3	-0.8	0.2	0.6	0.4	0.2	0.8	0.6	0.2	0.4	0.7	0.4	0.2
Arm fat mass (right)	0.2	1.0	2.9	-0.2	0.8	1.0	1.6	1.7	1.0	-0.2	0.1	1.0	0.8	1.3	1.0	1.0
Hair/balding pattern: Pattern 4	0.2	0.4	2.6	1.0	0.1	-0.4	-0.2	-1.6	-0.1	0.5	-0.1	-0.1	-0.4	-0.4	-0.6	-0.1
Blood clot in the leg (DVT)	0.2	0.2	0.8	0.8	0.9	0.0	-0.2	0.6	-0.1	0.0	-0.7	-0.1	0.6	-0.2	0.1	-0.1
Headache pain in last month	0.2	0.4	1.8	1.3	1.2	-0.0	0.3	0.4	-0.1	0.6	0.9	-0.1	-0.5	-0.6	0.2	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.6	3.4	-0.5	1.9	0.2	0.5	0.0	0.3	0.5	0.4	0.3	1.6	-0.3	-0.1	0.3
Exposure to tobacco smoke outside home	0.2	0.2	1.2	-0.1	0.2	-0.1	-0.7	-1.1	-0.1	-0.2	0.4	-0.1	-1.0	0.1	0.1	-0.1
Age at first live birth	0.2	0.3	1.5	0.2	0.5	0.6	0.4	1.2	0.5	0.5	0.3	0.5	-0.3	0.3	0.7	0.5
Medication: Omeprazole	0.2	0.3	1.1	-0.6	-1.1	-0.2	0.0	-0.1	-0.2	-1.0	-0.9	-0.2	-0.2	-0.1	-0.4	-0.2
Medication: Seretide 50 evohaler	0.2	0.2	0.8	-0.3	-0.3	-0.2	-0.0	-0.4	-0.2	-0.7	-0.9	-0.2	0.8	0.1	-0.2	-0.2
Whole body fat mass	0.2	0.7	1.6	-1.2	0.0	0.7	1.3	1.0	0.6	-1.1	-0.6	0.6	0.4	1.2	0.8	0.6
Leg fat mass (right)	0.2	0.8	2.6	-0.6	0.8	1.0	1.6	1.2	0.9	-0.4	-0.0	0.9	0.3	1.1	0.9	0.9
Comparative height size at age 10	0.2	1.1	7.6	-1.9	-0.3	0.5	0.9	-0.4	0.3	-0.7	-0.2	0.3	2.8	0.5	0.7	0.3
Suffer from ‘nerves’	0.2	0.4	1.3	0.0	0.3	0.7	0.3	-1.1	0.8	0.5	0.0	0.8	-0.6	0.5	0.5	0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.0	1.0	-0.3	-0.5	-0.1	-0.4	-0.1	0.3	-0.9	-0.1	0.3	-0.2	-1.0	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.2	-0.5	-0.8	-0.4	-1.1	0.0	-0.5	-0.3	0.4	-0.5	-0.7	-0.3	-0.1	-0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.7	-0.8	-0.4	0.1	0.4	0.1	-0.2	-0.6	-0.6	-0.2	0.8	-0.1	0.4	-0.2
Average weekly red wine intake	0.2	0.3	1.3	1.1	1.1	-0.2	-0.1	0.3	-0.1	0.7	0.0	-0.1	-0.5	-0.5	-0.3	-0.1
Ever had bowel cancer screening	0.2	0.3	1.3	-0.7	-1.1	-0.0	-0.7	0.4	0.0	-0.3	0.2	0.0	-0.9	0.3	-0.3	0.0
Qualifications: nursing, teaching	0.2	0.3	0.7	0.8	0.4	-0.6	-0.1	0.4	-0.8	-0.0	-0.2	-0.8	-0.3	-0.5	-0.2	-0.8
Average weekly champagne plus white wine intake	0.2	0.3	0.8	-0.6	0.0	0.7	0.8	0.4	0.5	-0.0	-0.1	0.5	0.9	0.8	0.7	0.5
Hearing aid user	0.2	0.2	0.6	-0.8	-0.7	-0.0	0.3	-0.8	0.2	-0.6	0.2	0.2	-0.0	0.1	-0.2	0.2
Medication: Paracetamol	0.2	0.3	1.5	0.5	0.6	-0.2	-0.4	-1.2	0.1	0.3	0.3	0.1	-1.2	-0.4	-0.6	0.1
Risk taking	0.2	0.3	1.4	-0.9	-0.3	0.3	-0.7	-1.2	0.2	-0.4	-0.3	0.2	0.8	0.4	0.3	0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.0	0.1	0.1	0.2	0.7	0.1	0.4	0.3	0.4	0.4	-1.0	0.1	-0.2	0.4
Age started oral contraceptive pill	0.2	0.3	0.8	0.8	0.3	-0.5	0.3	0.9	-0.4	0.1	0.2	-0.4	0.7	-0.5	-0.6	-0.4
Ever depressed for a whole week	0.2	0.2	0.5	0.2	0.3	0.5	0.3	0.5	0.5	0.7	0.5	0.5	0.6	0.5	0.2	0.5
Leg fat mass (left)	0.2	0.6	1.8	-0.7	0.6	0.7	1.3	1.0	0.7	-0.6	-0.3	0.7	0.4	1.0	0.8	0.7
Depression (Nagel 2018)	0.1	0.2	1.4	0.9	0.1	-0.1	-0.4	0.0	-0.1	0.5	0.3	-0.1	-1.2	-0.1	-0.0	-0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.3	-0.2	0.4	-0.1	-0.3	0.3	-0.0	-0.0	0.3	0.1	0.2	0.6	0.3
Irritable Bowel Disease (IBD)	0.1	0.2	1.2	0.3	1.1	-0.3	-0.2	0.1	-0.2	0.1	0.0	-0.2	-0.2	-0.5	-0.5	-0.2
Bipolar Disorder (2011)	0.1	0.1	0.4	-0.6	-0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.1	0.2	1.1	-0.6	-0.1	0.0	0.0	-0.0	-0.1	-0.5	-0.7	-0.1	1.1	0.0	0.2	-0.1
Fasting Glucose	0.1	0.1	0.6	-0.5	0.4	-0.1	-0.4	-0.8	-0.1	-0.3	0.4	-0.1	-0.6	-0.2	-0.1	-0.1
Blood Eosinophil Count	0.1	0.7	7.1	0.5	2.7	0.0	0.0	1.1	-0.1	0.4	-0.1	-0.1	0.3	-0.8	0.1	-0.1
Blood Red Count	0.1	1.2	6.4	0.5	1.0	0.5	0.1	0.4	0.8	1.5	2.5	0.8	-1.9	0.4	0.4	0.8
Hypothyroidism (self reported)	0.1	0.1	0.4	0.7	-0.4	0.0	-0.3	0.6	-0.1	0.0	-0.5	-0.1	-0.7	0.3	-0.0	-0.1
Chronotype (morning person)	0.1	0.3	2.3	1.5	0.5	-0.5	-0.5	-0.0	-0.4	0.5	0.3	-0.4	0.2	-0.1	-0.4	-0.4
Sensitivity / hurt feelings	0.1	0.2	1.1	-0.1	0.4	0.2	-0.1	-1.0	0.2	-0.2	-0.5	0.2	-1.0	0.1	0.3	0.2
Body mass index (BMI)	0.1	0.6	3.6	0.9	1.9	0.3	1.0	1.4	0.4	0.1	-0.1	0.4	-0.1	0.2	0.3	0.4
Waist circumference	0.1	0.4	1.5	-1.2	-0.1	0.3	0.8	0.2	0.4	-1.2	-0.5	0.4	0.3	0.7	-0.0	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.8	-0.2	-1.3	-0.0	0.3	0.3	-0.1	0.1	0.6	-0.1	0.7	0.3	0.2	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	1.0	0.2	-1.0	-0.1	0.4	-0.2	0.1	0.5	0.6	0.1	0.8	0.3	-0.1	0.1
Birth weight of first child	0.1	0.3	0.7	-0.3	0.6	0.5	0.5	0.8	0.3	-0.2	0.0	0.3	0.8	0.4	0.8	0.3
Pulse wave reflection index	0.1	0.2	0.7	-0.8	-0.5	0.1	0.1	-0.7	0.1	-0.3	-0.1	0.1	-0.8	0.2	0.3	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	1.1	1.0	-0.2	0.1	-0.1	0.2	0.2	0.6	-0.3	0.2	-0.3	0.2	-0.1	0.2
Birth weight	0.1	0.1	1.2	0.4	0.3	-0.0	0.4	0.2	-0.0	0.2	0.1	-0.0	1.1	-0.3	-0.1	-0.0
High blood pressure (siblings)	0.1	0.2	0.8	0.4	-0.9	-0.2	0.0	-0.2	0.3	0.7	0.2	0.3	0.1	-0.3	-0.8	0.3
Body fat percentage	0.1	0.5	2.2	-1.0	-0.8	0.2	0.6	0.2	0.1	-1.5	-1.0	0.1	-0.8	0.8	0.2	0.1
Leg fat percentage (right)	0.1	0.4	2.6	-0.5	0.7	-0.0	0.6	0.1	-0.0	-1.0	-0.6	-0.0	-1.6	0.2	-0.0	-0.0
Comparative body size at age 10	0.1	0.3	1.8	0.1	-0.7	-0.4	-0.9	-0.3	-0.2	-0.5	0.3	-0.2	-1.4	0.2	-0.4	-0.2
Worry too long after embarrassment	0.1	0.1	0.7	0.2	0.3	0.2	0.2	-0.1	0.3	0.3	0.4	0.3	-0.8	-0.0	0.1	0.3
Angina (self-reported)	0.1	0.2	0.5	0.7	0.7	-0.3	-0.1	0.1	-0.1	0.3	-0.3	-0.1	0.7	-0.5	-0.6	-0.1
Heart disease (mother)	0.1	0.2	0.8	0.9	-0.3	0.2	0.5	0.2	0.2	0.7	0.0	0.2	0.3	0.1	0.2	0.2
Alcohol intake frequency.	0.1	0.2	1.4	0.8	-0.0	-0.5	1.2	-0.3	-0.3	0.3	0.1	-0.3	-0.1	-0.3	-0.4	-0.3
Medication: Aspirin	0.1	0.1	0.6	0.2	0.0	-0.1	0.1	0.4	-0.2	-0.1	-0.8	-0.2	-0.5	-0.4	-0.1	-0.2
Arm fat percentage (left)	0.1	0.3	1.1	-0.3	-0.2	0.4	1.0	0.7	0.4	-0.9	-0.5	0.4	-0.5	0.8	0.3	0.4
Medication: Aspirin	0.1	0.1	0.5	0.4	0.2	0.0	0.1	0.4	-0.1	0.0	-0.7	-0.1	-0.4	-0.4	0.1	-0.1
Arm fat mass (left)	0.1	0.6	1.8	-0.5	0.8	0.7	1.3	1.3	0.6	-0.7	-0.3	0.6	0.4	0.9	0.7	0.6
Financial situation satisfaction	0.1	0.1	0.7	0.0	-0.9	-0.5	-0.1	-0.2	-0.4	-0.0	-0.0	-0.4	0.3	0.1	-0.3	-0.4
Leg fat percentage (left)	0.1	0.4	2.3	-0.6	0.2	-0.2	0.3	-0.0	-0.3	-1.2	-0.8	-0.3	-1.5	0.2	-0.1	-0.3
Myopia	0.1	0.2	0.9	0.0	-0.2	-0.1	-0.0	1.0	-0.3	-0.1	0.5	-0.3	-0.6	0.2	0.2	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.9	1.0	0.7	-0.0	-0.3	0.6	-0.1	0.2	-0.6	-0.1	0.5	-0.1	0.0	-0.1
Hair Pigment	0.0	1.2	5.9	2.1	0.7	-0.3	-1.7	-0.9	-0.3	0.5	0.1	-0.3	-2.4	0.3	-0.2	-0.3
Ever smoked	0.0	0.1	0.3	-0.2	-0.6	-0.2	-0.2	-0.6	-0.1	0.2	0.3	-0.1	0.1	-0.2	-0.1	-0.1

Hub : Genes

PKD2L1

Models

Trait associations