Hub : Genes

PKHD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0658	0.0279	0.00130	0.000	0.030	0.025	NA	0.002	3.6e-01	0.00024	6.9e-04	NA	1.9e-01
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0640	0.0236	0.00015	0.045	0.026	0.023	NA	0.033	7.3e-06	0.00057	1.0e-03	NA	1.1e-04
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1490	0.0570	0.00069	-0.004	0.025	0.027	NA	0.017	6.0e-01	0.01300	1.1e-02	NA	3.6e-02
4	TCGA	Lung Adenocarcinoma	0.0314	0.0151	0.00430	0.025	0.021	0.023	NA	0.023	5.2e-04	0.00150	9.7e-04	NA	9.5e-04
5	TCGA	Lung Squamous Cell Carcinoma	0.0446	0.0176	0.00011	0.054	0.033	0.045	NA	0.051	8.9e-07	0.00011	6.7e-06	NA	1.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.9	1.5	5.5	-0.0	-0.4	1.2	2.4	-0.3
Bipolar Disorder or Schizophrenia	0.4	1.1	2.9	0.9	-1.7	-0.4	1.2	0.3
Depressed Affect (Nagel 2018)	2.6	5.4	8.4	-2.0	-0.3	2.7	2.9	-2.7
Depression (Nagel 2018)	2.8	4.2	11.1	-0.4	1.0	3.3	2.4	-1.8
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	-0.1	0.9	-0.3	0.3	-0.3
Neuroticism (Nagel 2018)	2.5	6.0	8.8	-2.0	0.9	2.9	2.8	-3.0
Schizophrenia (2018)	0.7	1.5	3.3	1.1	-1.8	-1.5	-0.3	0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	0.2	0.4	-0.5	-0.8	0.5
Worry (Nagel 2018)	0.5	1.0	1.7	0.2	1.2	1.0	0.7	-1.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.7	0.8	-0.1	-1.3	-1.0	0.2
Alzheimer’s Disease (in father)	0.9	0.9	1.9	0.4	1.2	-0.1	-1.0	1.4
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	1.0	1.0	-0.4	-0.6	0.7
Crohns Disease (2017)	0.1	0.1	0.4	0.3	-0.6	-0.1	0.5	0.2
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	-0.3	-0.1	-0.5	0.0	0.1
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.2	0.5	-0.3	-0.4	0.5
Major Depression (MDD)	1.5	1.8	5.5	2.4	-0.7	-0.4	-0.6	1.6
Reaction Time	0.5	0.9	2.3	-0.2	-1.0	-1.0	0.1	1.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.1	-1.1	0.4	0.1	1.3	-1.4
Breast Cancer	0.2	0.5	1.3	1.1	0.8	0.4	0.5	0.5
Ovarian Cancer	0.2	0.3	0.8	-0.6	-0.1	-0.9	-0.4	-0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.7	1.0	2.2	-0.1	1.5	-1.2	-1.0	0.7
Bipolar Disorder (2011)	1.4	1.4	4.7	-0.1	-0.7	1.2	2.2	-0.1
Body Mass Index (BMI) (2010)	0.6	0.8	2.6	0.2	0.1	1.2	-0.1	-1.6
Coronary Artery Disease (CAD)	0.4	0.5	1.6	0.6	-0.7	-1.3	-0.4	-0.4
Crohns Disease (2012)	0.2	0.3	1.1	0.3	1.1	-0.1	-0.2	0.7
Mean Putamen Volume	0.1	0.1	0.4	-0.6	0.1	-0.0	0.0	-0.4
Fasting Glucose	0.5	0.6	1.7	-0.5	1.3	0.3	-0.3	-0.9
HbA1C	0.4	0.4	1.6	-0.5	-0.1	-0.4	1.3	0.4
HDL Cholesterol	0.1	0.2	0.6	0.4	-0.8	0.3	0.1	-0.4
LDL Cholesterol	0.2	0.4	1.3	-0.0	-1.1	-0.8	0.2	0.1
Lupus	1.1	1.6	2.8	0.7	-1.6	-1.7	-0.6	1.3
Neuroticism (2016)	0.3	0.5	0.8	0.0	-0.8	0.8	0.6	-0.9
Primary Biliary Cirrhosis	0.8	1.2	2.4	-1.5	-0.4	0.6	1.4	-1.1
Rheumatoid Arthritis	1.6	2.2	4.9	1.6	1.0	2.2	0.4	-1.6
Schizophrenia (2014)	0.5	1.1	3.5	0.6	-1.9	-1.2	0.1	-0.2
Triglycerides	0.4	0.6	1.2	-0.2	1.1	-0.9	-0.9	0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.9	-1.4	0.6	0.3	-0.4	-1.0
Ulcerative Colitis	0.5	0.7	2.0	-1.4	0.8	-0.8	-0.6	0.2
Blood Eosinophil Count	0.2	1.5	4.6	2.1	1.1	-0.0	-1.3	0.0
Blood Platelet Count	0.7	7.6	20.1	0.2	2.8	4.5	2.7	-1.5
Blood Red Count	0.7	6.3	23.2	0.8	-4.8	-2.7	-0.6	-0.2
Blood White Count	0.3	2.5	5.1	-1.7	1.4	1.5	0.6	-2.3
Heel T-Score	0.1	0.6	1.4	0.4	-0.8	0.8	1.2	0.1
BMI	3.8	21.8	53.3	-3.3	0.0	5.3	4.0	-7.3
Height	0.0	0.6	2.5	0.4	-0.1	0.5	-0.3	-1.6
Waist Hip Ratio (WHR)	0.2	0.9	2.2	1.5	0.3	1.1	0.7	-0.4
Systolic Blood Pressure	0.7	3.5	9.0	0.1	-2.9	-0.2	0.1	-3.0
Smoking Status	0.4	0.9	3.3	1.0	-1.8	-0.3	-0.2	0.2
Allergy or Eczema	0.2	0.5	1.1	-0.6	0.4	0.7	1.0	-0.8
Cardiovascular Disease	2.4	7.9	25.1	-1.8	-5.0	-0.7	2.1	-2.6
Hypothyroidism (self reported)	0.2	0.5	1.1	-0.6	-0.1	1.1	0.8	-0.7
Respiratory disease	0.7	1.5	3.8	1.4	2.0	0.6	-1.3	-0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.5	0.9	-0.9	0.3	-0.1	-0.8	-0.8
Lung FEV1/FVC ratio	0.5	2.6	5.5	-2.4	-0.8	-2.2	-1.2	-0.3
Lung FVC	0.4	2.1	4.8	0.4	2.1	2.2	1.0	0.2
Neuroticism	1.5	3.5	6.0	-1.1	1.2	2.3	2.0	-2.4
Chronotype (morning person)	1.1	2.5	5.7	-1.6	-0.5	1.5	1.3	-2.4
Hair Pigment	1.1	31.7	49.7	-6.5	-0.7	4.7	6.6	-7.0
Tanning	0.5	6.2	20.7	4.5	0.6	0.6	-1.8	2.5
Hand grip strength (left)	0.6	1.5	3.3	1.3	1.3	1.8	0.4	-0.8
Number of treatments/medications taken	0.3	0.6	0.8	0.8	-0.8	0.9	0.6	-0.7
Average weekly spirits intake	0.1	0.2	0.4	0.5	0.5	0.6	-0.2	-0.2
Sensitivity / hurt feelings	2.6	4.4	9.9	0.1	0.6	3.1	2.4	-2.4
Frequency of depressed mood in last 2 weeks	1.6	2.3	6.1	0.4	-0.6	2.5	2.0	-0.8
Hearing difficulty/problems: Yes	1.7	2.6	5.6	1.8	0.6	-1.3	-2.4	1.4
Relative age of first facial hair	0.6	1.1	3.5	-1.4	1.9	-0.6	0.1	-0.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.2	-1.0	1.2	1.1	0.6	-1.5
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.6	0.7	-0.9	0.7	1.6	1.4
Ever had hysterectomy (womb removed)	1.6	1.8	4.4	0.7	-2.1	1.0	1.7	-0.2
Systolic blood pressure, automated reading	0.7	2.0	5.7	-0.2	-1.8	0.8	0.7	-2.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.5	0.8	-1.6	-0.8	-0.3	0.5
Angina	1.1	1.5	2.8	-1.5	-1.7	-0.0	0.4	-1.4
Medication for hormone replacement therapy	1.7	1.9	3.5	1.4	-1.6	-1.2	-0.4	1.9
Vitamin and mineral supplements	0.4	0.5	1.7	0.6	-1.3	-0.1	-0.5	-0.5
Supplements: Zinc	0.6	0.7	1.3	0.2	-1.1	-0.3	0.9	1.1
Medication: Co-codamol	0.3	0.3	0.5	0.3	0.7	-0.0	-0.6	0.7
Medication: Metformin	0.1	0.2	0.8	0.4	0.1	-0.1	-0.9	0.2
Diabetes (father)	1.0	1.3	2.7	-0.0	1.4	-1.3	-1.6	-0.4
Diabetes (mother)	0.4	0.6	1.1	-0.8	0.1	-0.9	-0.6	1.0
Severe depression (siblings)	0.2	0.3	0.7	0.8	-0.1	-0.5	-0.5	0.4
Pack years adult smoking proportion	0.4	0.6	1.5	-0.6	0.1	-0.9	-1.2	0.6
Impedance of leg (right)	1.2	5.8	12.1	2.8	-2.1	-1.9	-0.9	3.5
Leg fat-free mass (left)	1.4	7.2	17.5	-2.0	1.1	3.3	1.7	-4.2
Trunk fat percentage	2.8	11.3	23.5	-2.2	-1.6	3.4	3.8	-4.8
Hand grip strength (right)	0.3	0.9	1.5	1.1	1.2	1.2	0.2	-0.7
Townsend deprivation index at recruitment	0.2	0.2	0.6	-0.5	-0.8	-0.4	-0.3	0.0
Current tobacco smoking	0.3	0.4	1.6	0.5	-0.2	-0.5	-1.2	0.5
Average weekly fortified wine intake	0.2	0.2	0.6	-0.4	-0.1	0.1	0.8	-0.3
Maternal smoking around birth	1.1	1.6	6.5	0.1	-2.6	-0.5	0.9	0.4
Fed-up feelings	1.6	3.0	5.9	-0.8	0.3	2.4	1.9	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.3	7.2	-1.3	1.2	2.7	1.7	-1.8
Relative age voice broke	0.6	0.9	3.1	-0.8	-0.1	-1.8	-0.3	-0.7
Taking other prescription medications	1.3	2.0	5.1	0.8	0.6	2.3	1.8	-0.9
Age when periods started (menarche)	0.9	2.1	5.8	1.9	-0.9	-0.5	-0.2	2.4
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	5.0	0.6	-2.2	0.1	0.9	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.3	-0.1	0.2	-0.5	-1.1	0.5
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	5.8	2.4	0.0	-0.6	-1.3	1.8
Qualifications: CSEs or equivalent	0.7	0.9	2.4	-0.6	0.6	1.5	1.0	-0.6
Serious illness, injury or assault to yourself	0.3	0.4	0.8	0.9	0.2	0.9	-0.5	-0.2
High blood pressure	1.6	4.6	17.6	0.7	-4.2	-1.1	1.1	-1.5
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.7	0.1	0.0	0.8	0.7	0.0
Multivitamins +/- minerals	1.3	1.6	4.9	-1.4	2.2	0.5	0.8	-0.5
Stomach or abdominal pain in last month	2.0	2.5	4.6	-1.3	0.3	2.2	1.6	-1.9
Supplements: Glucosamine	0.0	0.0	0.1	0.3	-0.0	-0.2	-0.1	-0.2
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.4	0.5	0.7	1.9	1.0	0.8
Medication: Atenolol	0.3	0.4	1.5	0.5	-1.2	-0.3	-0.1	-0.3
Medication: Levothyroxine sodium	1.1	1.9	3.8	-1.1	0.3	1.9	1.9	-1.1
Sitting height	0.1	0.6	1.3	0.4	-1.1	-0.9	-0.8	0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.8	0.9	-0.2	0.3	0.1	0.2
High blood pressure (mother)	1.2	1.7	4.2	-0.1	-0.3	1.8	2.1	-0.9
Body mass index (BMI)	3.1	13.1	28.7	-3.0	0.1	4.1	3.4	-5.4
Impedance of leg (left)	1.3	6.3	12.4	2.6	-2.3	-2.5	-0.9	3.5
Leg predicted mass (left)	1.3	6.8	16.8	-1.9	1.0	3.2	1.6	-4.1
Trunk fat mass	3.2	13.5	29.6	-2.5	-1.1	4.0	3.8	-5.4
Waist circumference	3.6	13.2	34.0	-2.4	-0.4	3.9	3.2	-5.8
Number of incorrect matches in round	0.4	0.6	1.3	0.7	1.1	0.7	-0.9	-0.2
Past tobacco smoking	0.5	0.8	2.3	0.3	1.5	-0.6	-0.9	0.9
Alcohol usually taken with meals	0.4	0.6	1.5	-1.2	1.0	-0.3	0.6	-0.0
Nervous feelings	0.5	0.9	2.9	1.0	1.7	0.7	0.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.9	0.1	-0.3	0.9	1.0	0.3
Hearing difficulty/problems with background noise	1.9	3.0	6.5	1.1	-0.4	-2.5	-2.3	1.4
Hair/balding pattern: Pattern 2	0.9	1.1	3.0	0.5	0.0	-1.3	-1.7	0.8
Had menopause	0.2	0.3	0.5	-0.3	0.7	0.1	-0.5	-0.7
Had other major operations	1.6	1.9	4.9	1.0	1.0	2.2	1.2	-1.0
Forced vital capacity (FVC)	0.3	1.0	3.2	0.1	1.1	1.8	0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.4	-0.3	0.2	0.2	-0.2
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.9	-0.6	0.5	1.7	1.1	0.1
Qualifications: None of the above	0.4	0.9	2.9	0.8	-0.0	0.5	-0.7	-1.7
Financial difficulties in last 2 years	2.0	2.7	7.5	-0.8	-2.7	0.0	2.3	-0.5
Mouth/teeth dental problems	0.8	1.2	2.6	0.2	1.3	1.6	0.5	-1.2
Heart attack	0.1	0.1	0.6	-0.8	-0.2	-0.1	-0.1	0.3
Allergy	0.3	0.6	1.3	-0.6	-0.9	-1.1	0.2	0.6
Pain all over the body in last month	3.1	3.3	6.4	2.1	2.3	-0.6	-2.5	0.5
Diabetes (self-reported)	0.2	0.3	0.7	-0.3	0.7	0.2	-0.8	-0.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	-1.4	0.7	0.6	0.9	0.5
Medication: Ramipril	0.6	0.7	1.7	1.2	-1.3	0.0	0.1	-0.7
Medication: Simvastatin	2.2	3.3	12.3	0.6	-3.5	-1.6	-0.8	-0.8
Fluid intelligence score	0.8	1.7	3.4	-1.2	0.5	0.7	1.7	-1.8
Illnesses of siblings	1.1	1.6	4.8	0.3	1.7	0.5	-0.2	2.2
Neuroticism score	1.0	2.0	4.4	0.4	0.4	2.1	1.2	-2.0
Weight	2.6	12.8	29.9	-2.7	0.1	4.2	3.1	-5.5
Impedance of arm (right)	0.5	2.1	4.5	1.2	-1.7	-2.1	-0.3	1.3
Arm fat percentage (right)	3.9	15.3	34.5	-2.9	-1.1	4.0	4.0	-5.9
Trunk fat-free mass	0.9	5.2	11.0	-1.5	1.2	3.2	1.1	-3.3
Hip circumference	3.4	14.6	34.1	-3.2	-0.1	4.0	3.4	-5.8
Time employed in main current job	0.5	0.5	1.2	0.8	0.8	-0.1	-1.1	-0.3
Alcohol intake versus 10 years previously	0.6	0.9	2.6	0.6	-1.6	-1.0	-0.8	-0.0
Father’s age at death	0.4	0.6	2.0	0.8	0.3	-0.5	0.1	1.4
Worrier / anxious feelings	0.2	0.4	1.6	-0.1	1.3	0.2	-0.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.8	1.1	0.2	1.7	1.4	-0.6
Falls in the last year	0.3	0.4	1.1	-0.6	-1.1	-0.1	0.0	-0.9
Hair/balding pattern: Pattern 3	1.1	1.6	4.1	1.2	-0.0	-1.4	-2.0	0.7
Number of live births	1.1	1.5	3.6	-0.1	-0.8	1.4	1.1	-1.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.7	-0.7	1.0	1.3	0.3	-0.9
Pulse rate	0.7	1.2	2.7	1.6	-1.6	-0.5	-0.0	0.9
Happiness	1.3	1.6	3.1	0.2	1.4	1.7	0.2	-1.7
Noisy workplace	0.9	1.1	2.2	-0.3	-1.4	-1.5	-1.1	0.0
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.6	-1.9	1.9	-0.6	-0.9	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	-0.9	0.4	0.4	0.8	-0.6
Mouth/teeth dental problems: Dentures	2.2	3.8	6.9	2.0	-1.5	-2.0	-1.3	2.6
Asthma	1.2	2.5	5.4	2.3	1.9	0.3	-1.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.2	0.4	-1.1	0.3	-0.3	0.9
Medication: Cholesterol lowering	0.5	0.7	1.6	-0.2	-1.2	-0.7	-1.2	0.2
Depression (self-reported)	1.6	1.9	4.9	0.6	0.5	2.2	2.0	0.3
Medication: Lansoprazole	1.5	1.7	5.9	0.3	1.3	2.4	0.7	-0.5
Prospective memory result	1.5	1.8	3.2	1.0	-0.6	-1.5	-1.8	1.6
Lung cancer (father)	0.4	0.5	0.8	-0.8	0.7	0.9	0.8	-0.1
Illnesses of mother	0.0	0.0	0.1	0.1	0.3	-0.3	-0.0	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.6	-1.3	1.0	1.1	0.5	-1.6
Pulse wave Arterial Stiffness index	1.7	2.0	4.6	1.1	1.1	2.1	1.7	-0.7
Impedance of arm (left)	0.6	2.7	5.7	1.3	-1.7	-2.4	-0.8	1.6
Arm fat mass (right)	3.5	14.4	33.2	-2.8	-0.7	4.1	3.6	-5.8
Trunk predicted mass	0.9	4.9	10.2	-1.4	1.1	3.2	1.1	-3.2
Standing height	0.0	0.4	0.9	0.2	0.4	1.0	-0.1	-0.9
Length of working week for main job	1.6	1.8	4.4	2.1	1.8	0.4	-0.3	1.2
Exposure to tobacco smoke at home	0.9	1.0	1.6	-1.0	0.1	1.3	1.0	-1.2
Breastfed as a baby	1.6	2.0	5.3	-1.5	2.3	1.2	0.5	-0.9
Tense / ‘highly strung’	0.4	0.6	2.5	0.3	-0.1	0.7	0.3	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.7	0.9	-0.6	0.8	1.9	-0.3
Hair/balding pattern: Pattern 4	0.4	1.1	3.5	-0.3	-1.2	0.4	1.9	-0.1
Birth weight of first child	0.9	1.6	4.8	-1.6	-0.2	0.7	0.4	-2.2
Peak expiratory flow (PEF)	0.2	0.4	1.6	-0.3	0.3	0.1	-1.3	-0.2
Pulse wave reflection index	2.0	2.4	4.6	-0.8	2.1	1.7	0.5	-1.9
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.4	1.9	1.4	1.6	-0.4	0.2
Loud music exposure frequency	1.1	1.2	2.2	1.2	-0.7	-1.0	-1.1	1.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.3	-1.5	1.0	-0.5	-0.1	-0.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	5.5	-2.3	1.1	-0.1	0.0	-0.4
Blood clot in the leg (DVT)	0.2	0.3	0.9	0.2	0.4	-0.5	-0.9	0.1
Medication: Paracetamol	0.4	0.7	1.1	0.6	1.0	1.1	-0.6	-0.6
Headache pain in last month	0.3	0.5	1.3	-1.0	1.2	-0.1	-0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.9	-0.6	2.2	1.5	1.6	-0.1
Glaucoma (self-reported)	3.7	4.4	17.0	0.6	-4.1	0.1	2.1	-0.6
Gout (self-reported)	1.7	2.3	5.9	0.2	0.8	2.4	1.2	-1.8
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	2.9	-1.7	0.6	1.7	1.5	-1.4
Medication: Amlodipine	0.6	0.9	2.9	0.7	-1.7	-0.0	0.6	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.9	0.3	0.9	0.5	0.5
Birth weight	0.3	0.6	1.1	0.2	-1.0	-0.9	-0.7	-0.7
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.3	1.0	-1.5	-0.2	0.3	0.6
High blood pressure (siblings)	0.9	1.4	4.4	-0.7	-0.7	0.8	0.9	-2.1
Forced vital capacity (FVC), Best measure	0.3	1.1	2.8	-0.0	1.3	1.7	0.4	-0.9
Body fat percentage	3.1	12.1	24.7	-2.4	-1.6	3.6	3.9	-5.0
Leg fat percentage (right)	2.4	8.5	15.1	-1.3	-1.5	3.7	3.2	-3.9
Arm fat-free mass (right)	0.9	4.5	9.2	-1.4	0.8	3.0	1.4	-2.9
Exposure to tobacco smoke outside home	1.1	1.5	3.1	-1.8	-1.1	-0.2	0.5	-1.7
Comparative body size at age 10	2.8	7.8	17.4	-1.9	-0.5	3.0	3.0	-4.2
Number of full brothers	1.1	1.4	2.6	-0.9	0.8	-1.5	-1.6	-0.9
Worry too long after embarrassment	0.2	0.4	0.6	0.7	0.0	0.8	0.5	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	1.1	-1.1	0.2	0.9	0.2
Wheeze or whistling in the chest in last year	0.6	1.0	1.9	0.4	1.4	0.6	-1.0	-1.4
Number of children fathered	1.6	1.8	4.2	1.8	-1.0	-0.8	-0.3	2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.5	-1.1	-0.0	0.4	0.7	-1.6
Age at first live birth	0.7	1.2	2.6	-0.4	0.3	-1.6	-1.6	0.9
Pulse wave peak to peak time	1.4	1.7	3.5	-1.0	-1.1	-1.9	-1.6	0.5
Health satisfaction	2.6	3.4	8.5	0.9	1.1	2.9	0.7	-2.4
Shortness of breath walking on level ground	1.0	1.2	3.0	1.7	-0.7	-0.6	-1.1	-1.0
Qualifications: College or University degree	0.8	2.5	4.0	-0.5	1.1	-2.0	-1.8	1.9
Eye problems/disorders: None of the above	2.4	2.8	9.1	-0.6	3.0	-0.4	-2.0	0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	0.4	1.1	0.2	-0.4	1.2
Emphysema/chronic bronchitis	1.7	1.9	3.9	-1.9	-1.3	0.1	0.4	-2.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	-0.8	0.6	-0.1	0.8	-0.0
Neck or shoulder pain in last month	2.8	4.0	7.0	-0.7	-1.0	2.4	2.6	-2.4
Medication: Blood pressure	1.0	1.7	4.8	0.9	-2.2	-1.3	-1.2	-0.1
Angina (self-reported)	1.1	1.4	2.7	-1.6	-1.5	-0.1	0.5	-1.4
Migraine (self-reported)	0.4	0.5	1.7	-0.1	-1.3	0.3	0.9	-0.3
Medication: Ibuprofen	0.4	0.5	1.0	0.3	-1.0	0.3	-0.5	0.9
Medication: Allopurinol	1.1	1.4	3.0	0.5	-0.0	1.7	1.4	-1.4
Medication: Omeprazole	1.0	1.2	2.8	-0.1	1.1	1.7	1.4	-0.6
Medication: Seretide 50 evohaler	1.1	1.2	4.8	0.7	-2.2	-0.4	0.5	0.6
Mean time to correctly identify matches	0.6	1.2	2.7	0.2	-1.1	-1.4	-0.4	1.6
Heart disease (mother)	2.2	2.7	5.5	0.8	-1.4	-2.4	-2.2	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.7	-0.1	0.0	-1.3	-1.3	0.5
Whole body fat mass	3.1	12.9	27.1	-2.4	-0.9	4.1	3.7	-5.2
Leg fat mass (right)	2.6	10.1	20.5	-1.7	-0.8	4.0	3.2	-4.5
Arm predicted mass (right)	0.9	4.4	9.3	-1.3	0.6	3.0	1.4	-3.0
Pulse rate, automated reading	0.6	2.0	8.8	0.5	-3.0	-1.0	-0.2	0.3
Alcohol intake frequency.	1.0	2.4	6.1	0.1	-2.5	-1.7	-0.7	1.6
Comparative height size at age 10	0.1	0.8	2.6	-1.0	-0.1	0.5	0.5	-1.6
Number of full sisters	0.2	0.3	0.6	-0.4	-0.2	-0.8	-0.7	0.1
Suffer from ‘nerves’	1.2	1.9	4.0	0.2	0.3	2.0	2.0	-1.2
Overall health rating	1.7	3.6	9.4	-0.6	-0.8	2.2	1.8	-3.1
Chest pain or discomfort	0.4	0.5	1.3	-0.7	-0.4	-0.2	-0.7	-1.1
Had major operations	0.5	0.5	1.3	-0.8	1.1	0.8	0.2	-0.0
Age at last live birth	1.1	1.6	2.8	0.4	0.2	-1.5	-1.7	1.6
Family relationship satisfaction	0.5	0.6	1.4	-0.2	-0.7	0.6	0.8	-1.2
Leg pain on walking	0.8	1.1	4.0	-0.2	2.0	0.6	-0.9	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	-0.0	0.3	0.9	1.1	0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	0.4	-0.4	0.8	0.9	-0.4
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	3.8	1.0	0.1	-1.7	-2.0	1.3
Medication: Aspirin	0.7	1.0	3.2	0.3	-1.8	-1.2	-0.3	0.2
Supplements: Vitamin C	1.0	1.1	2.9	0.9	-1.1	-0.6	0.7	1.7
Knee pain experienced in last month	0.8	1.3	3.3	-1.1	-0.6	1.0	0.9	-1.8
Hypertension (Self-reported)	1.7	4.8	17.3	-0.2	-4.2	-1.1	1.2	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.7	-1.6	1.2	1.3	0.6	-0.4
Illnesses of father: Heart disease	0.3	0.4	1.7	1.3	-0.3	0.1	0.3	0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.9	-0.1	-0.2	0.2	0.8	-1.4
Smoking status: Previous	0.6	0.9	1.4	0.0	-1.2	0.9	1.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	4.3	-1.0	1.3	2.1	1.5	-1.1
Whole body fat-free mass	1.1	6.1	13.7	-1.6	1.2	3.3	1.4	-3.7
Leg fat-free mass (right)	1.2	6.5	15.8	-2.1	1.3	2.9	1.5	-4.0
Arm fat percentage (left)	3.8	15.2	33.9	-3.0	-1.1	4.0	4.0	-5.8
Average weekly red wine intake	1.0	1.5	2.4	-1.2	1.1	1.1	1.2	-1.6
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.1	-0.3	1.0	0.9	0.4	-0.8
Mood swings	0.6	1.1	2.9	-1.0	-0.2	1.1	0.5	-1.7
Loneliness, isolation	2.3	3.2	6.0	-1.1	-0.1	2.3	2.5	-1.9
Long-standing illness, disability or infirmity	0.5	0.8	1.5	0.5	1.0	1.2	0.3	-1.0
Ever had bowel cancer screening	0.5	0.6	1.0	0.6	0.7	1.0	1.0	0.7
Diabetes diagnosed by doctor	0.0	0.1	0.2	-0.4	0.1	-0.1	-0.4	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	-0.7	0.4	-0.3	-0.8	-0.2
Friendships satisfaction	2.2	2.7	5.9	-0.5	1.2	2.2	1.0	-2.4
Qualifications: nursing, teaching	2.7	4.2	18.4	-1.2	4.3	0.7	-0.9	-0.1
Commuting to job workplace: Walk	0.6	0.6	1.2	0.4	-0.4	-1.1	-1.0	0.8
Eye problems/disorders: Cataract	3.0	3.5	7.4	-1.3	-2.0	1.0	2.7	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.7	-1.3	-0.5	-1.1	-0.7	-0.9
Medication for cholesterol	1.6	2.4	9.5	-0.5	3.1	0.6	-1.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.0	0.9	-1.7	-0.3	-0.2	-0.4
Back pain experienced in last month	0.4	0.6	1.4	-1.1	-0.1	0.4	0.3	-1.2
Mineral and other dietary supplements	0.9	1.2	3.9	1.3	-2.0	0.6	0.4	-0.3
Breast cancer (self-reported)	1.0	1.2	3.5	-1.9	-0.3	-0.4	-0.1	-1.6
Asthma (self-reported)	1.2	2.5	5.9	2.4	1.7	0.1	-1.9	0.2
Osteoporosis (self-reported)	0.6	0.7	1.4	-0.9	-0.3	-1.2	-0.3	-1.1
Osteoarthritis (self-reported)	0.7	1.0	1.7	-1.3	1.3	-0.9	-0.7	-0.5
Medication: Aspirin	0.7	1.0	2.8	0.3	-1.7	-1.3	-0.4	-0.1
Medication: Gliclazide	0.8	0.9	2.8	0.1	-0.1	-1.2	-1.7	-0.5
Illnesses of father: None of the above (group 1)	1.4	1.8	4.7	-2.2	0.5	1.2	0.9	-1.3
Smoking status: Current	0.3	0.4	1.5	0.1	-0.2	-0.6	-1.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.0	-1.0	-0.1	0.4	0.3	-0.5
Whole body water mass	1.1	6.4	14.3	-1.8	1.1	3.3	1.5	-3.8
Leg predicted mass (right)	1.2	6.2	15.5	-2.0	1.2	2.8	1.5	-3.9
Arm fat mass (left)	3.5	14.3	32.4	-2.7	-0.7	4.2	3.7	-5.7
Number of self-reported non-cancer illnesses	0.5	0.8	1.5	0.7	-0.9	0.8	1.2	-0.7
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.2	-0.7	-0.6	0.1	-0.2
Miserableness	0.9	1.6	4.5	-1.1	-0.7	0.9	1.1	-2.1
Guilty feelings	0.8	1.3	2.3	-0.2	1.1	1.5	1.3	-1.0
Wears glasses or contact lenses	1.2	1.4	2.7	1.2	0.2	-0.4	-1.6	1.6
Ever taken oral contraceptive pill	0.7	0.8	1.9	1.1	0.4	0.5	-0.6	1.4
Hearing aid user	0.6	0.7	1.4	-0.3	-0.6	0.7	1.2	-0.9
Mother’s age at death	0.2	0.3	1.0	-1.0	-0.1	0.2	0.4	0.2
Financial situation satisfaction	1.4	1.7	4.8	-0.1	-0.7	1.5	0.9	-2.2
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	-0.6	-0.4	0.2	0.8	-0.4
Commuting to job workplace: Public transport	2.2	2.7	6.4	-0.4	-1.4	-2.5	-1.2	1.8
Eye problems/disorders: Glaucoma	2.6	3.0	12.3	1.3	-3.5	-0.1	1.1	0.1
Medication: Blood pressure	1.2	2.3	9.4	0.7	-3.1	-0.8	0.5	-0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	-0.2	-0.2	0.7	0.7	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.0	4.6	-0.3	2.1	0.0	-0.5	0.5
High cholesterol (Self-reported)	0.7	1.3	5.2	-0.4	-2.3	-0.9	0.6	-0.3
Medication: Bendroflumethiazide	1.7	2.6	9.1	0.9	-3.0	-0.1	1.7	0.5
Medication: Paracetamol	0.2	0.3	0.9	0.5	0.5	1.0	-0.3	-0.1
Medication: Lisinopril	1.2	1.6	3.5	-0.0	-1.9	-0.7	-1.4	-1.4
Medication: Atorvastatin	1.2	1.4	3.6	-1.9	1.0	0.9	1.2	-0.6
Illnesses of father: High blood pressure	0.8	0.9	2.5	0.6	-1.6	-0.9	-0.3	-1.0
Alcohol drinker status: Never	1.3	1.6	3.2	-1.7	-1.2	-0.0	0.5	-1.8
Ever smoked	0.3	0.6	1.8	-0.5	-1.3	-0.6	-0.6	-0.4
Basal metabolic rate	1.4	7.8	18.0	-2.0	0.8	3.6	1.9	-4.2
Leg fat percentage (left)	2.3	8.3	15.5	-1.6	-1.4	3.4	3.2	-3.9
Arm fat-free mass (left)	1.0	5.0	11.2	-1.4	0.9	3.1	1.3	-3.4
Number of operations (self-reported)	1.7	2.5	7.4	0.2	0.9	2.7	2.0	-0.3
Average weekly beer plus cider intake	1.3	1.9	4.0	-1.6	-2.0	-1.2	0.3	-1.2
Irritability	1.5	2.5	4.4	-0.9	1.7	2.1	0.5	-2.1
Risk taking	0.9	1.4	3.6	1.9	-0.4	0.4	-0.2	1.8
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.8	-1.2	1.9	1.2	0.1	-0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.9	0.5	-0.9	-0.1	0.6	-0.2
Age started oral contraceptive pill	0.9	1.2	3.5	-1.9	0.9	0.9	0.5	-0.6
Diastolic blood pressure, automated reading	2.9	9.1	33.1	1.2	-5.7	0.8	2.3	-2.2
Ever depressed for a whole week	0.6	0.8	1.8	1.2	0.4	0.4	-0.5	1.4
Unable to work because of sickness or disability	1.8	2.3	5.8	-0.6	-0.5	2.0	2.4	-1.0
Commuting to job workplace: Cycle	0.6	0.7	1.6	-0.1	-0.2	-1.2	-0.7	1.2
Myopia	0.7	1.0	2.1	0.4	-1.0	-1.2	-0.5	1.5
Vascular/heart problems diagnosed by doctor	1.5	4.1	16.3	-0.8	4.0	0.9	-1.1	1.3
Cholesterol lowering medication	1.2	1.8	6.7	0.1	-2.6	-0.3	1.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.8	0.0	0.7	1.9	1.5	-1.0
Pain experienced in last month	1.1	1.8	4.8	1.3	-0.8	-1.3	-0.0	2.2
Supplements: Calcium	0.5	0.5	1.3	-1.2	0.1	-1.0	-0.6	0.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.6	-1.2	-0.7	-0.6	-0.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.5	-0.2	-0.3	-0.3	0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	0.1	0.4	-0.3	-0.8	-0.1
Heart disease (siblings)	0.7	0.9	1.5	-1.1	0.1	-0.9	-1.2	-1.0
Alcohol drinker status: Previous	0.5	0.6	1.7	-0.4	0.4	0.8	1.3	0.4
Pack years of smoking	0.3	0.5	1.3	-0.4	0.3	-0.7	-1.2	0.6
Impedance of whole body	1.1	5.5	8.9	2.1	-2.0	-2.9	-1.1	3.0
Leg fat mass (left)	2.6	10.1	21.6	-2.0	-0.9	3.7	3.2	-4.7
Arm predicted mass (left)	1.0	5.1	11.2	-1.5	0.7	3.0	1.5	-3.3