Hub : Genes

PKHD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Head and Neck Squamous Cell Carcinoma 0.0658 0.0279 0.00130 0.000 0.030 0.025 NA 0.002 3.6e-01 0.00024 6.9e-04 NA 1.9e-01
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0640 0.0236 0.00015 0.045 0.026 0.023 NA 0.033 7.3e-06 0.00057 1.0e-03 NA 1.1e-04
3 TCGA Kidney Renal Papillary Cell Carcinoma 0.1490 0.0570 0.00069 -0.004 0.025 0.027 NA 0.017 6.0e-01 0.01300 1.1e-02 NA 3.6e-02
4 TCGA Lung Adenocarcinoma 0.0314 0.0151 0.00430 0.025 0.021 0.023 NA 0.023 5.2e-04 0.00150 9.7e-04 NA 9.5e-04
5 TCGA Lung Squamous Cell Carcinoma 0.0446 0.0176 0.00011 0.054 0.033 0.045 NA 0.051 8.9e-07 0.00011 6.7e-06 NA 1.6e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.9 1.5 5.5 -0.0 -0.4 1.2 2.4 -0.3
Bipolar Disorder or Schizophrenia 0.4 1.1 2.9 0.9 -1.7 -0.4 1.2 0.3
Depressed Affect (Nagel 2018) 2.6 5.4 8.4 -2.0 -0.3 2.7 2.9 -2.7
Depression (Nagel 2018) 2.8 4.2 11.1 -0.4 1.0 3.3 2.4 -1.8
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.7 -0.1 0.9 -0.3 0.3 -0.3
Neuroticism (Nagel 2018) 2.5 6.0 8.8 -2.0 0.9 2.9 2.8 -3.0
Schizophrenia (2018) 0.7 1.5 3.3 1.1 -1.8 -1.5 -0.3 0.6
Schizophrenia vs Biploar Disorder 0.2 0.3 0.7 0.2 0.4 -0.5 -0.8 0.5
Worry (Nagel 2018) 0.5 1.0 1.7 0.2 1.2 1.0 0.7 -1.3
Alzheimer’s Disease (in mother) 0.6 0.7 1.7 0.8 -0.1 -1.3 -1.0 0.2
Alzheimer’s Disease (in father) 0.9 0.9 1.9 0.4 1.2 -0.1 -1.0 1.4
Alzheimer’s Disease (including proxy) 0.4 0.6 1.0 1.0 1.0 -0.4 -0.6 0.7
Crohns Disease (2017) 0.1 0.1 0.4 0.3 -0.6 -0.1 0.5 0.2
Irritable Bowel Disease (IBD) 0.0 0.1 0.3 -0.3 -0.1 -0.5 0.0 0.1
Ulcerative Colitis (UC) 0.1 0.2 0.3 -0.2 0.5 -0.3 -0.4 0.5
Major Depression (MDD) 1.5 1.8 5.5 2.4 -0.7 -0.4 -0.6 1.6
Reaction Time 0.5 0.9 2.3 -0.2 -1.0 -1.0 0.1 1.5
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.1 -1.1 0.4 0.1 1.3 -1.4
Breast Cancer 0.2 0.5 1.3 1.1 0.8 0.4 0.5 0.5
Ovarian Cancer 0.2 0.3 0.8 -0.6 -0.1 -0.9 -0.4 -0.4
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.7 1.0 2.2 -0.1 1.5 -1.2 -1.0 0.7
Bipolar Disorder (2011) 1.4 1.4 4.7 -0.1 -0.7 1.2 2.2 -0.1
Body Mass Index (BMI) (2010) 0.6 0.8 2.6 0.2 0.1 1.2 -0.1 -1.6
Coronary Artery Disease (CAD) 0.4 0.5 1.6 0.6 -0.7 -1.3 -0.4 -0.4
Crohns Disease (2012) 0.2 0.3 1.1 0.3 1.1 -0.1 -0.2 0.7
Mean Putamen Volume 0.1 0.1 0.4 -0.6 0.1 -0.0 0.0 -0.4
Fasting Glucose 0.5 0.6 1.7 -0.5 1.3 0.3 -0.3 -0.9
HbA1C 0.4 0.4 1.6 -0.5 -0.1 -0.4 1.3 0.4
HDL Cholesterol 0.1 0.2 0.6 0.4 -0.8 0.3 0.1 -0.4
LDL Cholesterol 0.2 0.4 1.3 -0.0 -1.1 -0.8 0.2 0.1
Lupus 1.1 1.6 2.8 0.7 -1.6 -1.7 -0.6 1.3
Neuroticism (2016) 0.3 0.5 0.8 0.0 -0.8 0.8 0.6 -0.9
Primary Biliary Cirrhosis 0.8 1.2 2.4 -1.5 -0.4 0.6 1.4 -1.1
Rheumatoid Arthritis 1.6 2.2 4.9 1.6 1.0 2.2 0.4 -1.6
Schizophrenia (2014) 0.5 1.1 3.5 0.6 -1.9 -1.2 0.1 -0.2
Triglycerides 0.4 0.6 1.2 -0.2 1.1 -0.9 -0.9 0.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.9 -1.4 0.6 0.3 -0.4 -1.0
Ulcerative Colitis 0.5 0.7 2.0 -1.4 0.8 -0.8 -0.6 0.2
Blood Eosinophil Count 0.2 1.5 4.6 2.1 1.1 -0.0 -1.3 0.0
Blood Platelet Count 0.7 7.6 20.1 0.2 2.8 4.5 2.7 -1.5
Blood Red Count 0.7 6.3 23.2 0.8 -4.8 -2.7 -0.6 -0.2
Blood White Count 0.3 2.5 5.1 -1.7 1.4 1.5 0.6 -2.3
Heel T-Score 0.1 0.6 1.4 0.4 -0.8 0.8 1.2 0.1
BMI 3.8 21.8 53.3 -3.3 0.0 5.3 4.0 -7.3
Height 0.0 0.6 2.5 0.4 -0.1 0.5 -0.3 -1.6
Waist Hip Ratio (WHR) 0.2 0.9 2.2 1.5 0.3 1.1 0.7 -0.4
Systolic Blood Pressure 0.7 3.5 9.0 0.1 -2.9 -0.2 0.1 -3.0
Smoking Status 0.4 0.9 3.3 1.0 -1.8 -0.3 -0.2 0.2
Allergy or Eczema 0.2 0.5 1.1 -0.6 0.4 0.7 1.0 -0.8
Cardiovascular Disease 2.4 7.9 25.1 -1.8 -5.0 -0.7 2.1 -2.6
Hypothyroidism (self reported) 0.2 0.5 1.1 -0.6 -0.1 1.1 0.8 -0.7
Respiratory disease 0.7 1.5 3.8 1.4 2.0 0.6 -1.3 -0.3
Type 2 Diabetes (T2D) (2018) 0.2 0.5 0.9 -0.9 0.3 -0.1 -0.8 -0.8
Lung FEV1/FVC ratio 0.5 2.6 5.5 -2.4 -0.8 -2.2 -1.2 -0.3
Lung FVC 0.4 2.1 4.8 0.4 2.1 2.2 1.0 0.2
Neuroticism 1.5 3.5 6.0 -1.1 1.2 2.3 2.0 -2.4
Chronotype (morning person) 1.1 2.5 5.7 -1.6 -0.5 1.5 1.3 -2.4
Hair Pigment 1.1 31.7 49.7 -6.5 -0.7 4.7 6.6 -7.0
Tanning 0.5 6.2 20.7 4.5 0.6 0.6 -1.8 2.5
Hand grip strength (left) 0.6 1.5 3.3 1.3 1.3 1.8 0.4 -0.8
Number of treatments/medications taken 0.3 0.6 0.8 0.8 -0.8 0.9 0.6 -0.7
Average weekly spirits intake 0.1 0.2 0.4 0.5 0.5 0.6 -0.2 -0.2
Sensitivity / hurt feelings 2.6 4.4 9.9 0.1 0.6 3.1 2.4 -2.4
Frequency of depressed mood in last 2 weeks 1.6 2.3 6.1 0.4 -0.6 2.5 2.0 -0.8
Hearing difficulty/problems: Yes 1.7 2.6 5.6 1.8 0.6 -1.3 -2.4 1.4
Relative age of first facial hair 0.6 1.1 3.5 -1.4 1.9 -0.6 0.1 -0.1
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 2.2 -1.0 1.2 1.1 0.6 -1.5
Ever used hormone-replacement therapy (HRT) 1.0 1.3 2.6 0.7 -0.9 0.7 1.6 1.4
Ever had hysterectomy (womb removed) 1.6 1.8 4.4 0.7 -2.1 1.0 1.7 -0.2
Systolic blood pressure, automated reading 0.7 2.0 5.7 -0.2 -1.8 0.8 0.7 -2.4
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 2.5 0.8 -1.6 -0.8 -0.3 0.5
Angina 1.1 1.5 2.8 -1.5 -1.7 -0.0 0.4 -1.4
Medication for hormone replacement therapy 1.7 1.9 3.5 1.4 -1.6 -1.2 -0.4 1.9
Vitamin and mineral supplements 0.4 0.5 1.7 0.6 -1.3 -0.1 -0.5 -0.5
Supplements: Zinc 0.6 0.7 1.3 0.2 -1.1 -0.3 0.9 1.1
Medication: Co-codamol 0.3 0.3 0.5 0.3 0.7 -0.0 -0.6 0.7
Medication: Metformin 0.1 0.2 0.8 0.4 0.1 -0.1 -0.9 0.2
Diabetes (father) 1.0 1.3 2.7 -0.0 1.4 -1.3 -1.6 -0.4
Diabetes (mother) 0.4 0.6 1.1 -0.8 0.1 -0.9 -0.6 1.0
Severe depression (siblings) 0.2 0.3 0.7 0.8 -0.1 -0.5 -0.5 0.4
Pack years adult smoking proportion 0.4 0.6 1.5 -0.6 0.1 -0.9 -1.2 0.6
Impedance of leg (right) 1.2 5.8 12.1 2.8 -2.1 -1.9 -0.9 3.5
Leg fat-free mass (left) 1.4 7.2 17.5 -2.0 1.1 3.3 1.7 -4.2
Trunk fat percentage 2.8 11.3 23.5 -2.2 -1.6 3.4 3.8 -4.8
Hand grip strength (right) 0.3 0.9 1.5 1.1 1.2 1.2 0.2 -0.7
Townsend deprivation index at recruitment 0.2 0.2 0.6 -0.5 -0.8 -0.4 -0.3 0.0
Current tobacco smoking 0.3 0.4 1.6 0.5 -0.2 -0.5 -1.2 0.5
Average weekly fortified wine intake 0.2 0.2 0.6 -0.4 -0.1 0.1 0.8 -0.3
Maternal smoking around birth 1.1 1.6 6.5 0.1 -2.6 -0.5 0.9 0.4
Fed-up feelings 1.6 3.0 5.9 -0.8 0.3 2.4 1.9 -2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.5 3.3 7.2 -1.3 1.2 2.7 1.7 -1.8
Relative age voice broke 0.6 0.9 3.1 -0.8 -0.1 -1.8 -0.3 -0.7
Taking other prescription medications 1.3 2.0 5.1 0.8 0.6 2.3 1.8 -0.9
Age when periods started (menarche) 0.9 2.1 5.8 1.9 -0.9 -0.5 -0.2 2.4
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 5.0 0.6 -2.2 0.1 0.9 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.3 -0.1 0.2 -0.5 -1.1 0.5
Tinnitus: Yes, but not now, but have in the past 2.1 2.2 5.8 2.4 0.0 -0.6 -1.3 1.8
Qualifications: CSEs or equivalent 0.7 0.9 2.4 -0.6 0.6 1.5 1.0 -0.6
Serious illness, injury or assault to yourself 0.3 0.4 0.8 0.9 0.2 0.9 -0.5 -0.2
High blood pressure 1.6 4.6 17.6 0.7 -4.2 -1.1 1.1 -1.5
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.7 0.1 0.0 0.8 0.7 0.0
Multivitamins +/- minerals 1.3 1.6 4.9 -1.4 2.2 0.5 0.8 -0.5
Stomach or abdominal pain in last month 2.0 2.5 4.6 -1.3 0.3 2.2 1.6 -1.9
Supplements: Glucosamine 0.0 0.0 0.1 0.3 -0.0 -0.2 -0.1 -0.2
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 3.4 0.5 0.7 1.9 1.0 0.8
Medication: Atenolol 0.3 0.4 1.5 0.5 -1.2 -0.3 -0.1 -0.3
Medication: Levothyroxine sodium 1.1 1.9 3.8 -1.1 0.3 1.9 1.9 -1.1
Sitting height 0.1 0.6 1.3 0.4 -1.1 -0.9 -0.8 0.5
Chronic bronchitis/emphysema (father) 0.2 0.2 0.8 0.9 -0.2 0.3 0.1 0.2
High blood pressure (mother) 1.2 1.7 4.2 -0.1 -0.3 1.8 2.1 -0.9
Body mass index (BMI) 3.1 13.1 28.7 -3.0 0.1 4.1 3.4 -5.4
Impedance of leg (left) 1.3 6.3 12.4 2.6 -2.3 -2.5 -0.9 3.5
Leg predicted mass (left) 1.3 6.8 16.8 -1.9 1.0 3.2 1.6 -4.1
Trunk fat mass 3.2 13.5 29.6 -2.5 -1.1 4.0 3.8 -5.4
Waist circumference 3.6 13.2 34.0 -2.4 -0.4 3.9 3.2 -5.8
Number of incorrect matches in round 0.4 0.6 1.3 0.7 1.1 0.7 -0.9 -0.2
Past tobacco smoking 0.5 0.8 2.3 0.3 1.5 -0.6 -0.9 0.9
Alcohol usually taken with meals 0.4 0.6 1.5 -1.2 1.0 -0.3 0.6 -0.0
Nervous feelings 0.5 0.9 2.9 1.0 1.7 0.7 0.0 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.9 0.1 -0.3 0.9 1.0 0.3
Hearing difficulty/problems with background noise 1.9 3.0 6.5 1.1 -0.4 -2.5 -2.3 1.4
Hair/balding pattern: Pattern 2 0.9 1.1 3.0 0.5 0.0 -1.3 -1.7 0.8
Had menopause 0.2 0.3 0.5 -0.3 0.7 0.1 -0.5 -0.7
Had other major operations 1.6 1.9 4.9 1.0 1.0 2.2 1.2 -1.0
Forced vital capacity (FVC) 0.3 1.0 3.2 0.1 1.1 1.8 0.6 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.2 -0.4 -0.3 0.2 0.2 -0.2
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 2.9 -0.6 0.5 1.7 1.1 0.1
Qualifications: None of the above 0.4 0.9 2.9 0.8 -0.0 0.5 -0.7 -1.7
Financial difficulties in last 2 years 2.0 2.7 7.5 -0.8 -2.7 0.0 2.3 -0.5
Mouth/teeth dental problems 0.8 1.2 2.6 0.2 1.3 1.6 0.5 -1.2
Heart attack 0.1 0.1 0.6 -0.8 -0.2 -0.1 -0.1 0.3
Allergy 0.3 0.6 1.3 -0.6 -0.9 -1.1 0.2 0.6
Pain all over the body in last month 3.1 3.3 6.4 2.1 2.3 -0.6 -2.5 0.5
Diabetes (self-reported) 0.2 0.3 0.7 -0.3 0.7 0.2 -0.8 -0.4
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.0 -1.4 0.7 0.6 0.9 0.5
Medication: Ramipril 0.6 0.7 1.7 1.2 -1.3 0.0 0.1 -0.7
Medication: Simvastatin 2.2 3.3 12.3 0.6 -3.5 -1.6 -0.8 -0.8
Fluid intelligence score 0.8 1.7 3.4 -1.2 0.5 0.7 1.7 -1.8
Illnesses of siblings 1.1 1.6 4.8 0.3 1.7 0.5 -0.2 2.2
Neuroticism score 1.0 2.0 4.4 0.4 0.4 2.1 1.2 -2.0
Weight 2.6 12.8 29.9 -2.7 0.1 4.2 3.1 -5.5
Impedance of arm (right) 0.5 2.1 4.5 1.2 -1.7 -2.1 -0.3 1.3
Arm fat percentage (right) 3.9 15.3 34.5 -2.9 -1.1 4.0 4.0 -5.9
Trunk fat-free mass 0.9 5.2 11.0 -1.5 1.2 3.2 1.1 -3.3
Hip circumference 3.4 14.6 34.1 -3.2 -0.1 4.0 3.4 -5.8
Time employed in main current job 0.5 0.5 1.2 0.8 0.8 -0.1 -1.1 -0.3
Alcohol intake versus 10 years previously 0.6 0.9 2.6 0.6 -1.6 -1.0 -0.8 -0.0
Father’s age at death 0.4 0.6 2.0 0.8 0.3 -0.5 0.1 1.4
Worrier / anxious feelings 0.2 0.4 1.6 -0.1 1.3 0.2 -0.3 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 2.8 1.1 0.2 1.7 1.4 -0.6
Falls in the last year 0.3 0.4 1.1 -0.6 -1.1 -0.1 0.0 -0.9
Hair/balding pattern: Pattern 3 1.1 1.6 4.1 1.2 -0.0 -1.4 -2.0 0.7
Number of live births 1.1 1.5 3.6 -0.1 -0.8 1.4 1.1 -1.9
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.7 -0.7 1.0 1.3 0.3 -0.9
Pulse rate 0.7 1.2 2.7 1.6 -1.6 -0.5 -0.0 0.9
Happiness 1.3 1.6 3.1 0.2 1.4 1.7 0.2 -1.7
Noisy workplace 0.9 1.1 2.2 -0.3 -1.4 -1.5 -1.1 0.0
Qualifications: A levels/AS levels or equivalent 0.8 1.7 3.6 -1.9 1.9 -0.6 -0.9 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 0.8 -0.9 0.4 0.4 0.8 -0.6
Mouth/teeth dental problems: Dentures 2.2 3.8 6.9 2.0 -1.5 -2.0 -1.3 2.6
Asthma 1.2 2.5 5.4 2.3 1.9 0.3 -1.8 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.2 0.4 -1.1 0.3 -0.3 0.9
Medication: Cholesterol lowering 0.5 0.7 1.6 -0.2 -1.2 -0.7 -1.2 0.2
Depression (self-reported) 1.6 1.9 4.9 0.6 0.5 2.2 2.0 0.3
Medication: Lansoprazole 1.5 1.7 5.9 0.3 1.3 2.4 0.7 -0.5
Prospective memory result 1.5 1.8 3.2 1.0 -0.6 -1.5 -1.8 1.6
Lung cancer (father) 0.4 0.5 0.8 -0.8 0.7 0.9 0.8 -0.1
Illnesses of mother 0.0 0.0 0.1 0.1 0.3 -0.3 -0.0 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 2.6 -1.3 1.0 1.1 0.5 -1.6
Pulse wave Arterial Stiffness index 1.7 2.0 4.6 1.1 1.1 2.1 1.7 -0.7
Impedance of arm (left) 0.6 2.7 5.7 1.3 -1.7 -2.4 -0.8 1.6
Arm fat mass (right) 3.5 14.4 33.2 -2.8 -0.7 4.1 3.6 -5.8
Trunk predicted mass 0.9 4.9 10.2 -1.4 1.1 3.2 1.1 -3.2
Standing height 0.0 0.4 0.9 0.2 0.4 1.0 -0.1 -0.9
Length of working week for main job 1.6 1.8 4.4 2.1 1.8 0.4 -0.3 1.2
Exposure to tobacco smoke at home 0.9 1.0 1.6 -1.0 0.1 1.3 1.0 -1.2
Breastfed as a baby 1.6 2.0 5.3 -1.5 2.3 1.2 0.5 -0.9
Tense / ‘highly strung’ 0.4 0.6 2.5 0.3 -0.1 0.7 0.3 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 3.7 0.9 -0.6 0.8 1.9 -0.3
Hair/balding pattern: Pattern 4 0.4 1.1 3.5 -0.3 -1.2 0.4 1.9 -0.1
Birth weight of first child 0.9 1.6 4.8 -1.6 -0.2 0.7 0.4 -2.2
Peak expiratory flow (PEF) 0.2 0.4 1.6 -0.3 0.3 0.1 -1.3 -0.2
Pulse wave reflection index 2.0 2.4 4.6 -0.8 2.1 1.7 0.5 -1.9
Ever highly irritable/argumentative for 2 days 1.3 1.6 3.4 1.9 1.4 1.6 -0.4 0.2
Loud music exposure frequency 1.1 1.2 2.2 1.2 -0.7 -1.0 -1.1 1.5
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 2.3 -1.5 1.0 -0.5 -0.1 -0.8
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 5.5 -2.3 1.1 -0.1 0.0 -0.4
Blood clot in the leg (DVT) 0.2 0.3 0.9 0.2 0.4 -0.5 -0.9 0.1
Medication: Paracetamol 0.4 0.7 1.1 0.6 1.0 1.1 -0.6 -0.6
Headache pain in last month 0.3 0.5 1.3 -1.0 1.2 -0.1 -0.5 -0.1
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 4.9 -0.6 2.2 1.5 1.6 -0.1
Glaucoma (self-reported) 3.7 4.4 17.0 0.6 -4.1 0.1 2.1 -0.6
Gout (self-reported) 1.7 2.3 5.9 0.2 0.8 2.4 1.2 -1.8
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 2.9 -1.7 0.6 1.7 1.5 -1.4
Medication: Amlodipine 0.6 0.9 2.9 0.7 -1.7 -0.0 0.6 -0.7
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.8 0.9 0.3 0.9 0.5 0.5
Birth weight 0.3 0.6 1.1 0.2 -1.0 -0.9 -0.7 -0.7
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.3 1.0 -1.5 -0.2 0.3 0.6
High blood pressure (siblings) 0.9 1.4 4.4 -0.7 -0.7 0.8 0.9 -2.1
Forced vital capacity (FVC), Best measure 0.3 1.1 2.8 -0.0 1.3 1.7 0.4 -0.9
Body fat percentage 3.1 12.1 24.7 -2.4 -1.6 3.6 3.9 -5.0
Leg fat percentage (right) 2.4 8.5 15.1 -1.3 -1.5 3.7 3.2 -3.9
Arm fat-free mass (right) 0.9 4.5 9.2 -1.4 0.8 3.0 1.4 -2.9
Exposure to tobacco smoke outside home 1.1 1.5 3.1 -1.8 -1.1 -0.2 0.5 -1.7
Comparative body size at age 10 2.8 7.8 17.4 -1.9 -0.5 3.0 3.0 -4.2
Number of full brothers 1.1 1.4 2.6 -0.9 0.8 -1.5 -1.6 -0.9
Worry too long after embarrassment 0.2 0.4 0.6 0.7 0.0 0.8 0.5 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.3 1.1 -1.1 0.2 0.9 0.2
Wheeze or whistling in the chest in last year 0.6 1.0 1.9 0.4 1.4 0.6 -1.0 -1.4
Number of children fathered 1.6 1.8 4.2 1.8 -1.0 -0.8 -0.3 2.0
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 2.5 -1.1 -0.0 0.4 0.7 -1.6
Age at first live birth 0.7 1.2 2.6 -0.4 0.3 -1.6 -1.6 0.9
Pulse wave peak to peak time 1.4 1.7 3.5 -1.0 -1.1 -1.9 -1.6 0.5
Health satisfaction 2.6 3.4 8.5 0.9 1.1 2.9 0.7 -2.4
Shortness of breath walking on level ground 1.0 1.2 3.0 1.7 -0.7 -0.6 -1.1 -1.0
Qualifications: College or University degree 0.8 2.5 4.0 -0.5 1.1 -2.0 -1.8 1.9
Eye problems/disorders: None of the above 2.4 2.8 9.1 -0.6 3.0 -0.4 -2.0 0.8
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.4 0.4 1.1 0.2 -0.4 1.2
Emphysema/chronic bronchitis 1.7 1.9 3.9 -1.9 -1.3 0.1 0.4 -2.0
Medication for pain relief, constipation, heartburn 0.2 0.3 0.6 -0.8 0.6 -0.1 0.8 -0.0
Neck or shoulder pain in last month 2.8 4.0 7.0 -0.7 -1.0 2.4 2.6 -2.4
Medication: Blood pressure 1.0 1.7 4.8 0.9 -2.2 -1.3 -1.2 -0.1
Angina (self-reported) 1.1 1.4 2.7 -1.6 -1.5 -0.1 0.5 -1.4
Migraine (self-reported) 0.4 0.5 1.7 -0.1 -1.3 0.3 0.9 -0.3
Medication: Ibuprofen 0.4 0.5 1.0 0.3 -1.0 0.3 -0.5 0.9
Medication: Allopurinol 1.1 1.4 3.0 0.5 -0.0 1.7 1.4 -1.4
Medication: Omeprazole 1.0 1.2 2.8 -0.1 1.1 1.7 1.4 -0.6
Medication: Seretide 50 evohaler 1.1 1.2 4.8 0.7 -2.2 -0.4 0.5 0.6
Mean time to correctly identify matches 0.6 1.2 2.7 0.2 -1.1 -1.4 -0.4 1.6
Heart disease (mother) 2.2 2.7 5.5 0.8 -1.4 -2.4 -2.2 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.7 -0.1 0.0 -1.3 -1.3 0.5
Whole body fat mass 3.1 12.9 27.1 -2.4 -0.9 4.1 3.7 -5.2
Leg fat mass (right) 2.6 10.1 20.5 -1.7 -0.8 4.0 3.2 -4.5
Arm predicted mass (right) 0.9 4.4 9.3 -1.3 0.6 3.0 1.4 -3.0
Pulse rate, automated reading 0.6 2.0 8.8 0.5 -3.0 -1.0 -0.2 0.3
Alcohol intake frequency. 1.0 2.4 6.1 0.1 -2.5 -1.7 -0.7 1.6
Comparative height size at age 10 0.1 0.8 2.6 -1.0 -0.1 0.5 0.5 -1.6
Number of full sisters 0.2 0.3 0.6 -0.4 -0.2 -0.8 -0.7 0.1
Suffer from ‘nerves’ 1.2 1.9 4.0 0.2 0.3 2.0 2.0 -1.2
Overall health rating 1.7 3.6 9.4 -0.6 -0.8 2.2 1.8 -3.1
Chest pain or discomfort 0.4 0.5 1.3 -0.7 -0.4 -0.2 -0.7 -1.1
Had major operations 0.5 0.5 1.3 -0.8 1.1 0.8 0.2 -0.0
Age at last live birth 1.1 1.6 2.8 0.4 0.2 -1.5 -1.7 1.6
Family relationship satisfaction 0.5 0.6 1.4 -0.2 -0.7 0.6 0.8 -1.2
Leg pain on walking 0.8 1.1 4.0 -0.2 2.0 0.6 -0.9 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.1 -0.0 0.3 0.9 1.1 0.5
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.8 0.4 -0.4 0.8 0.9 -0.4
Illness, injury, bereavement, stress in last 2 years 1.5 1.9 3.8 1.0 0.1 -1.7 -2.0 1.3
Medication: Aspirin 0.7 1.0 3.2 0.3 -1.8 -1.2 -0.3 0.2
Supplements: Vitamin C 1.0 1.1 2.9 0.9 -1.1 -0.6 0.7 1.7
Knee pain experienced in last month 0.8 1.3 3.3 -1.1 -0.6 1.0 0.9 -1.8
Hypertension (Self-reported) 1.7 4.8 17.3 -0.2 -4.2 -1.1 1.2 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 2.7 -1.6 1.2 1.3 0.6 -0.4
Illnesses of father: Heart disease 0.3 0.4 1.7 1.3 -0.3 0.1 0.3 0.5
Illnesses of siblings: Diabetes 0.4 0.5 1.9 -0.1 -0.2 0.2 0.8 -1.4
Smoking status: Previous 0.6 0.9 1.4 0.0 -1.2 0.9 1.1 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 4.3 -1.0 1.3 2.1 1.5 -1.1
Whole body fat-free mass 1.1 6.1 13.7 -1.6 1.2 3.3 1.4 -3.7
Leg fat-free mass (right) 1.2 6.5 15.8 -2.1 1.3 2.9 1.5 -4.0
Arm fat percentage (left) 3.8 15.2 33.9 -3.0 -1.1 4.0 4.0 -5.8
Average weekly red wine intake 1.0 1.5 2.4 -1.2 1.1 1.1 1.2 -1.6
Handedness (chirality/laterality): Left-handed 0.5 0.5 1.1 -0.3 1.0 0.9 0.4 -0.8
Mood swings 0.6 1.1 2.9 -1.0 -0.2 1.1 0.5 -1.7
Loneliness, isolation 2.3 3.2 6.0 -1.1 -0.1 2.3 2.5 -1.9
Long-standing illness, disability or infirmity 0.5 0.8 1.5 0.5 1.0 1.2 0.3 -1.0
Ever had bowel cancer screening 0.5 0.6 1.0 0.6 0.7 1.0 1.0 0.7
Diabetes diagnosed by doctor 0.0 0.1 0.2 -0.4 0.1 -0.1 -0.4 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.7 -0.7 0.4 -0.3 -0.8 -0.2
Friendships satisfaction 2.2 2.7 5.9 -0.5 1.2 2.2 1.0 -2.4
Qualifications: nursing, teaching 2.7 4.2 18.4 -1.2 4.3 0.7 -0.9 -0.1
Commuting to job workplace: Walk 0.6 0.6 1.2 0.4 -0.4 -1.1 -1.0 0.8
Eye problems/disorders: Cataract 3.0 3.5 7.4 -1.3 -2.0 1.0 2.7 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 1.7 -1.3 -0.5 -1.1 -0.7 -0.9
Medication for cholesterol 1.6 2.4 9.5 -0.5 3.1 0.6 -1.3 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 3.0 0.9 -1.7 -0.3 -0.2 -0.4
Back pain experienced in last month 0.4 0.6 1.4 -1.1 -0.1 0.4 0.3 -1.2
Mineral and other dietary supplements 0.9 1.2 3.9 1.3 -2.0 0.6 0.4 -0.3
Breast cancer (self-reported) 1.0 1.2 3.5 -1.9 -0.3 -0.4 -0.1 -1.6
Asthma (self-reported) 1.2 2.5 5.9 2.4 1.7 0.1 -1.9 0.2
Osteoporosis (self-reported) 0.6 0.7 1.4 -0.9 -0.3 -1.2 -0.3 -1.1
Osteoarthritis (self-reported) 0.7 1.0 1.7 -1.3 1.3 -0.9 -0.7 -0.5
Medication: Aspirin 0.7 1.0 2.8 0.3 -1.7 -1.3 -0.4 -0.1
Medication: Gliclazide 0.8 0.9 2.8 0.1 -0.1 -1.2 -1.7 -0.5
Illnesses of father: None of the above (group 1) 1.4 1.8 4.7 -2.2 0.5 1.2 0.9 -1.3
Smoking status: Current 0.3 0.4 1.5 0.1 -0.2 -0.6 -1.2 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 1.0 -1.0 -0.1 0.4 0.3 -0.5
Whole body water mass 1.1 6.4 14.3 -1.8 1.1 3.3 1.5 -3.8
Leg predicted mass (right) 1.2 6.2 15.5 -2.0 1.2 2.8 1.5 -3.9
Arm fat mass (left) 3.5 14.3 32.4 -2.7 -0.7 4.2 3.7 -5.7
Number of self-reported non-cancer illnesses 0.5 0.8 1.5 0.7 -0.9 0.8 1.2 -0.7
Average weekly champagne plus white wine intake 0.1 0.2 0.5 -0.2 -0.7 -0.6 0.1 -0.2
Miserableness 0.9 1.6 4.5 -1.1 -0.7 0.9 1.1 -2.1
Guilty feelings 0.8 1.3 2.3 -0.2 1.1 1.5 1.3 -1.0
Wears glasses or contact lenses 1.2 1.4 2.7 1.2 0.2 -0.4 -1.6 1.6
Ever taken oral contraceptive pill 0.7 0.8 1.9 1.1 0.4 0.5 -0.6 1.4
Hearing aid user 0.6 0.7 1.4 -0.3 -0.6 0.7 1.2 -0.9
Mother’s age at death 0.2 0.3 1.0 -1.0 -0.1 0.2 0.4 0.2
Financial situation satisfaction 1.4 1.7 4.8 -0.1 -0.7 1.5 0.9 -2.2
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.7 -0.6 -0.4 0.2 0.8 -0.4
Commuting to job workplace: Public transport 2.2 2.7 6.4 -0.4 -1.4 -2.5 -1.2 1.8
Eye problems/disorders: Glaucoma 2.6 3.0 12.3 1.3 -3.5 -0.1 1.1 0.1
Medication: Blood pressure 1.2 2.3 9.4 0.7 -3.1 -0.8 0.5 -0.9
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.5 -0.2 -0.2 0.7 0.7 0.6
Supplements: Fish oil (including cod liver oil) 0.8 1.0 4.6 -0.3 2.1 0.0 -0.5 0.5
High cholesterol (Self-reported) 0.7 1.3 5.2 -0.4 -2.3 -0.9 0.6 -0.3
Medication: Bendroflumethiazide 1.7 2.6 9.1 0.9 -3.0 -0.1 1.7 0.5
Medication: Paracetamol 0.2 0.3 0.9 0.5 0.5 1.0 -0.3 -0.1
Medication: Lisinopril 1.2 1.6 3.5 -0.0 -1.9 -0.7 -1.4 -1.4
Medication: Atorvastatin 1.2 1.4 3.6 -1.9 1.0 0.9 1.2 -0.6
Illnesses of father: High blood pressure 0.8 0.9 2.5 0.6 -1.6 -0.9 -0.3 -1.0
Alcohol drinker status: Never 1.3 1.6 3.2 -1.7 -1.2 -0.0 0.5 -1.8
Ever smoked 0.3 0.6 1.8 -0.5 -1.3 -0.6 -0.6 -0.4
Basal metabolic rate 1.4 7.8 18.0 -2.0 0.8 3.6 1.9 -4.2
Leg fat percentage (left) 2.3 8.3 15.5 -1.6 -1.4 3.4 3.2 -3.9
Arm fat-free mass (left) 1.0 5.0 11.2 -1.4 0.9 3.1 1.3 -3.4
Number of operations (self-reported) 1.7 2.5 7.4 0.2 0.9 2.7 2.0 -0.3
Average weekly beer plus cider intake 1.3 1.9 4.0 -1.6 -2.0 -1.2 0.3 -1.2
Irritability 1.5 2.5 4.4 -0.9 1.7 2.1 0.5 -2.1
Risk taking 0.9 1.4 3.6 1.9 -0.4 0.4 -0.2 1.8
Ever had prostate specific antigen (PSA) test 1.2 1.4 3.8 -1.2 1.9 1.2 0.1 -0.5
Fractured/broken bones in last 5 years 0.2 0.3 0.9 0.5 -0.9 -0.1 0.6 -0.2
Age started oral contraceptive pill 0.9 1.2 3.5 -1.9 0.9 0.9 0.5 -0.6
Diastolic blood pressure, automated reading 2.9 9.1 33.1 1.2 -5.7 0.8 2.3 -2.2
Ever depressed for a whole week 0.6 0.8 1.8 1.2 0.4 0.4 -0.5 1.4
Unable to work because of sickness or disability 1.8 2.3 5.8 -0.6 -0.5 2.0 2.4 -1.0
Commuting to job workplace: Cycle 0.6 0.7 1.6 -0.1 -0.2 -1.2 -0.7 1.2
Myopia 0.7 1.0 2.1 0.4 -1.0 -1.2 -0.5 1.5
Vascular/heart problems diagnosed by doctor 1.5 4.1 16.3 -0.8 4.0 0.9 -1.1 1.3
Cholesterol lowering medication 1.2 1.8 6.7 0.1 -2.6 -0.3 1.3 -0.5
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 3.8 0.0 0.7 1.9 1.5 -1.0
Pain experienced in last month 1.1 1.8 4.8 1.3 -0.8 -1.3 -0.0 2.2
Supplements: Calcium 0.5 0.5 1.3 -1.2 0.1 -1.0 -0.6 0.0
Basal cell carcinoma (self-reported) 0.4 0.5 1.6 -1.2 -0.7 -0.6 -0.1 -0.3
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.3 -0.5 -0.2 -0.3 -0.3 0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.6 0.1 0.4 -0.3 -0.8 -0.1
Heart disease (siblings) 0.7 0.9 1.5 -1.1 0.1 -0.9 -1.2 -1.0
Alcohol drinker status: Previous 0.5 0.6 1.7 -0.4 0.4 0.8 1.3 0.4
Pack years of smoking 0.3 0.5 1.3 -0.4 0.3 -0.7 -1.2 0.6
Impedance of whole body 1.1 5.5 8.9 2.1 -2.0 -2.9 -1.1 3.0
Leg fat mass (left) 2.6 10.1 21.6 -2.0 -0.9 3.7 3.2 -4.7
Arm predicted mass (left) 1.0 5.1 11.2 -1.5 0.7 3.0 1.5 -3.3