Hub : Genes

PLAGL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Whole Blood 0.0750 0.0310 7.3e-03 0.023 NA 0.012 NA 0.017 3.3e-03 NA 2.6e-02 NA 9.7e-03
2 METSIM Adipose 0.0306 0.0140 7.1e-03 0.015 0.007 0.000 0.006 0.009 2.3e-03 3.0e-02 2.6e-01 3.2e-02 1.4e-02
3 NTR Blood 0.0416 0.0111 2.8e-07 0.005 0.025 0.019 0.025 0.016 5.3e-03 1.1e-08 5.9e-07 9.2e-09 4.7e-06
4 YFS Blood 0.1937 0.0293 0.0e+00 0.068 0.115 0.145 0.128 0.143 3.5e-21 1.1e-35 3.2e-45 8.3e-40 2.9e-44

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.0 1.7 3.1 -1.2 1.3 -1.8 -0.6
Bipolar Disorder or Schizophrenia 0.5 1.1 2.0 -0.8 1.0 -1.4 -1.0
Depressed Affect (Nagel 2018) 0.3 0.6 1.3 1.1 0.3 0.2 1.1
Depression (Nagel 2018) 1.0 1.4 2.5 -1.6 -1.5 -1.0 -0.1
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.5 -0.7 0.6 -0.1 -0.1
Neuroticism (Nagel 2018) 0.3 0.7 1.9 0.3 0.9 -1.4 0.2
Schizophrenia (2018) 0.1 0.2 0.6 -0.1 0.2 -0.4 -0.8
Schizophrenia vs Biploar Disorder 0.5 0.6 1.4 1.2 -0.1 1.0 -0.1
Worry (Nagel 2018) 0.3 0.7 1.9 0.9 -0.2 -1.4 -0.2
Alzheimer’s Disease (in mother) 2.2 2.6 5.7 2.4 0.4 1.9 0.9
Alzheimer’s Disease (in father) 2.4 2.6 7.8 0.0 -2.8 -0.8 1.4
Alzheimer’s Disease (including proxy) 0.7 1.1 1.6 1.2 -1.3 0.4 1.1
Crohns Disease (2017) 0.6 1.2 3.8 0.9 -0.3 0.4 -2.0
Irritable Bowel Disease (IBD) 0.7 1.7 3.0 1.7 0.8 1.6 -0.9
Ulcerative Colitis (UC) 1.5 2.8 5.3 2.1 1.1 2.3 0.2
Major Depression (MDD) 5.5 6.7 8.5 -2.5 2.9 -2.9 -2.0
Reaction Time 0.8 1.6 3.2 1.4 0.5 1.0 1.8
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.2 -0.3 0.5 -0.1 0.1
Breast Cancer 0.6 1.3 2.1 -1.3 -1.2 -0.2 -1.4
Ovarian Cancer 0.3 0.4 1.2 -0.5 -0.1 -0.2 -1.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.2 0.3 1.0 0.5 -0.2 1.0 0.0
Bipolar Disorder (2011) 1.0 1.0 2.7 -0.9 0.1 -1.6 -0.6
Body Mass Index (BMI) (2010) 0.1 0.1 0.2 -0.3 0.3 0.1 -0.4
Coronary Artery Disease (CAD) 0.4 0.5 1.2 0.7 -1.1 0.5 -0.3
Crohns Disease (2012) 0.2 0.3 1.1 -0.1 0.0 -0.1 -1.1
Mean Putamen Volume 0.5 0.5 1.3 0.9 -1.1 -0.2 -0.3
Fasting Glucose 0.2 0.2 0.4 -0.3 -0.3 -0.7 0.4
HbA1C 0.3 0.4 1.0 0.3 1.0 0.7 0.0
HDL Cholesterol 0.7 1.1 2.0 1.0 -0.1 -1.2 -1.4
LDL Cholesterol 0.0 0.1 0.1 -0.1 -0.4 -0.0 0.3
Lupus 1.7 2.6 4.5 1.6 -2.1 0.4 1.8
Neuroticism (2016) 0.2 0.2 1.0 -0.0 1.0 0.2 -0.0
Primary Biliary Cirrhosis 0.2 0.2 0.6 0.7 0.4 0.3 -0.4
Rheumatoid Arthritis 0.6 0.8 1.9 -0.7 -0.7 0.8 1.4
Schizophrenia (2014) 0.4 0.9 2.8 -0.4 0.3 -0.7 -1.7
Triglycerides 0.5 0.9 3.2 -1.8 0.5 -0.3 -0.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.1 -1.0 0.4 -1.0 -0.9
Ulcerative Colitis 2.3 3.4 6.6 2.6 1.1 2.4 0.2
Blood Eosinophil Count 1.3 10.3 16.8 3.0 -2.1 3.3 4.1
Blood Platelet Count 0.3 3.0 10.7 0.3 -3.3 0.6 0.8
Blood Red Count 0.5 4.8 8.4 1.8 -1.7 2.9 2.1
Blood White Count 0.1 0.4 1.0 -0.1 0.1 -1.0 -0.7
Heel T-Score 0.1 0.6 1.8 -0.0 -0.1 0.8 1.4
BMI 0.2 1.2 2.0 -1.4 0.6 1.1 -1.1
Height 0.1 1.0 1.7 0.9 1.2 -0.1 1.3
Waist Hip Ratio (WHR) 0.5 2.4 4.7 0.7 -2.2 1.4 1.5
Systolic Blood Pressure 0.4 2.1 6.9 -1.0 -2.6 0.1 0.7
Smoking Status 0.4 0.9 1.9 0.2 -0.4 -1.4 -1.2
Allergy or Eczema 0.2 0.5 1.1 -0.4 1.1 -0.5 -0.5
Cardiovascular Disease 1.3 4.4 12.0 -3.5 -1.6 -1.6 -0.8
Hypothyroidism (self reported) 1.0 2.3 8.0 -2.8 0.4 -0.4 -1.0
Respiratory disease 0.1 0.1 0.3 0.5 -0.3 0.5 -0.1
Type 2 Diabetes (T2D) (2018) 1.1 2.1 6.8 -0.9 2.6 0.2 -0.8
Lung FEV1/FVC ratio 0.2 0.8 2.6 1.6 -0.7 0.3 0.1
Lung FVC 2.1 10.9 35.0 -1.3 5.9 -2.6 0.4
Neuroticism 0.2 0.5 1.8 1.4 0.5 -0.3 0.2
Chronotype (morning person) 0.8 1.9 4.6 1.2 2.2 1.2 -0.2
Hair Pigment 0.1 3.2 5.0 1.9 -0.1 2.0 2.2
Tanning 0.2 2.0 3.6 -1.1 1.8 -0.3 -1.9
Hand grip strength (left) 0.5 1.3 4.1 -0.6 -2.0 -0.4 -0.9
Number of treatments/medications taken 0.8 1.4 4.2 -0.3 1.0 2.0 0.6
Average weekly spirits intake 0.6 0.7 2.3 -0.4 0.1 1.5 0.6
Sensitivity / hurt feelings 2.3 3.9 9.7 -0.7 2.2 -3.1 -0.6
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.1 -0.6 0.0 -0.1 1.0
Hearing difficulty/problems: Yes 0.6 0.9 1.2 -1.0 1.1 -0.6 -1.0
Relative age of first facial hair 0.3 0.5 0.9 -0.5 -1.0 0.2 0.9
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.0 0.9 -0.5 1.0 0.5
Ever used hormone-replacement therapy (HRT) 1.1 1.4 3.1 -1.0 1.2 1.8 -0.3
Ever had hysterectomy (womb removed) 0.7 0.8 2.3 -1.5 -0.3 -0.9 0.1
Systolic blood pressure, automated reading 1.0 3.0 4.7 -1.9 -2.2 -1.4 -1.3
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 2.9 1.7 1.4 1.1 -0.5
Angina 1.5 2.0 5.1 -2.2 -0.4 -1.6 -0.0
Medication for hormone replacement therapy 0.5 0.6 1.5 -0.1 0.5 1.2 -0.8
Vitamin and mineral supplements 1.0 1.4 4.8 -0.0 -2.2 -0.9 0.1
Supplements: Zinc 0.3 0.4 0.7 -0.8 0.8 -0.4 -0.0
Medication: Co-codamol 0.2 0.3 0.7 -0.4 0.4 -0.3 -0.8
Medication: Metformin 2.1 2.9 11.0 0.3 3.3 0.7 -0.1
Diabetes (father) 1.0 1.3 2.6 0.9 1.0 1.6 0.9
Diabetes (mother) 0.4 0.4 1.1 -0.1 1.1 0.4 -0.7
Severe depression (siblings) 0.2 0.2 0.2 0.5 0.4 -0.5 -0.4
Pack years adult smoking proportion 0.4 0.5 1.2 0.9 -1.1 0.4 -0.1
Impedance of leg (right) 0.2 0.9 1.8 1.3 -1.0 0.2 0.8
Leg fat-free mass (left) 0.1 0.7 1.1 -1.1 1.1 0.7 -0.4
Trunk fat percentage 0.1 0.4 1.0 -0.4 0.4 1.0 -0.5
Hand grip strength (right) 0.3 0.8 1.4 -0.8 -1.2 -0.1 -1.0
Townsend deprivation index at recruitment 0.8 1.1 3.4 -0.6 -0.3 -1.8 -0.8
Current tobacco smoking 0.3 0.4 1.4 -0.1 0.0 -1.2 -0.6
Average weekly fortified wine intake 0.8 0.9 2.0 -0.5 -1.4 0.1 -1.2
Maternal smoking around birth 0.4 0.6 1.3 -1.0 -0.2 -1.2 0.1
Fed-up feelings 0.2 0.4 0.6 0.5 0.6 -0.6 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.9 0.2 -1.2 -0.1 1.7
Relative age voice broke 0.6 0.8 2.6 0.5 -0.6 0.3 1.6
Taking other prescription medications 0.5 0.8 1.7 -0.6 0.9 0.7 -1.3
Age when periods started (menarche) 0.1 0.3 0.5 0.0 0.5 0.6 0.7
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.8 -1.3 0.5 -0.6 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.1 -0.7 1.0 -1.0 0.6
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 0.8 0.7 0.9 0.9 0.9
Qualifications: CSEs or equivalent 0.7 0.9 1.6 0.7 1.3 0.3 1.2
Serious illness, injury or assault to yourself 0.4 0.5 1.4 -0.2 -1.2 0.7 0.2
High blood pressure 0.7 1.8 4.6 -1.6 -2.1 0.1 0.5
Hayfever, allergic rhinitis or eczema 0.2 0.3 0.7 -0.1 0.8 0.3 -0.7
Multivitamins +/- minerals 1.1 1.4 5.1 -0.2 2.3 0.1 -0.5
Stomach or abdominal pain in last month 0.7 0.8 1.5 1.2 1.2 0.5 0.4
Supplements: Glucosamine 1.8 2.4 8.3 -0.7 2.9 0.1 0.9
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.7 0.0 0.8 0.4 0.4
Medication: Atenolol 0.8 1.0 3.0 0.4 1.7 0.9 0.3
Medication: Levothyroxine sodium 1.0 1.8 3.9 -2.0 1.2 -0.8 -1.0
Sitting height 0.1 0.9 1.8 0.4 1.4 0.2 1.2
Chronic bronchitis/emphysema (father) 0.0 0.0 0.2 0.4 0.1 0.0 -0.1
High blood pressure (mother) 2.2 3.1 5.3 -2.3 0.5 -1.9 -1.8
Body mass index (BMI) 0.3 1.5 1.8 -1.2 1.3 0.9 -1.4
Impedance of leg (left) 0.3 1.4 2.6 1.6 -1.2 0.7 1.0
Leg predicted mass (left) 0.1 0.7 1.3 -1.1 1.0 0.7 -0.4
Trunk fat mass 0.2 0.7 1.7 -0.6 0.8 1.3 -0.6
Waist circumference 0.2 0.7 2.4 -0.2 0.4 1.6 -0.4
Number of incorrect matches in round 0.3 0.5 1.2 0.1 -0.5 -1.1 -0.8
Past tobacco smoking 0.0 0.1 0.3 -0.2 0.1 0.2 0.5
Alcohol usually taken with meals 1.2 2.0 3.6 -0.4 1.9 1.0 -1.8
Nervous feelings 0.4 0.8 1.4 1.1 1.2 -0.4 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.7 -0.1 0.3 -0.8 0.5
Hearing difficulty/problems with background noise 0.1 0.2 0.5 -0.2 0.2 -0.7 -0.2
Hair/balding pattern: Pattern 2 0.4 0.5 1.2 0.4 0.5 -0.6 1.1
Had menopause 1.0 1.3 2.3 -1.2 1.2 -0.3 -1.5
Had other major operations 2.2 2.7 4.0 -2.0 0.8 -1.8 -1.7
Forced vital capacity (FVC) 1.0 4.0 12.2 0.4 3.5 -0.7 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.5 -1.1 0.3 -1.6 -0.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.3 -0.5 -0.8 -1.1 -0.6
Qualifications: None of the above 0.3 0.5 0.9 0.7 0.8 0.9 0.3
Financial difficulties in last 2 years 0.2 0.3 1.0 -0.0 1.0 -0.4 0.1
Mouth/teeth dental problems 0.9 1.3 3.0 -0.8 -1.1 1.7 0.6
Heart attack 1.8 2.4 5.5 -1.2 0.8 -1.4 -2.4
Allergy 0.1 0.3 0.7 0.6 -0.1 0.3 0.8
Pain all over the body in last month 0.1 0.1 0.2 -0.3 -0.4 0.1 0.1
Diabetes (self-reported) 1.1 1.7 5.7 -0.2 2.4 -0.4 -0.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.3 1.1 -0.1 1.1 -0.4
Medication: Ramipril 1.4 1.9 5.1 -1.0 1.1 -0.5 -2.3
Medication: Simvastatin 0.9 1.4 3.4 -1.0 1.9 -0.4 -1.0
Fluid intelligence score 0.1 0.3 0.5 -0.4 -0.7 0.3 0.5
Illnesses of siblings 0.4 0.5 0.8 0.9 0.4 0.9 -0.5
Neuroticism score 0.2 0.5 1.1 1.0 0.4 -0.5 0.6
Weight 0.2 1.2 2.2 -0.6 1.2 1.5 -1.0
Impedance of arm (right) 0.3 1.5 3.1 1.3 -1.1 -0.3 1.7
Arm fat percentage (right) 0.2 0.7 1.2 -0.8 1.1 0.8 -0.6
Trunk fat-free mass 0.2 1.1 1.4 -1.2 1.2 0.6 -1.1
Hip circumference 0.2 1.0 1.4 -0.7 1.2 0.8 -1.2
Time employed in main current job 0.5 0.6 0.8 0.9 0.9 0.8 0.5
Alcohol intake versus 10 years previously 0.5 0.7 1.9 1.4 0.2 0.8 -0.4
Father’s age at death 0.3 0.4 1.0 1.0 0.6 0.0 0.1
Worrier / anxious feelings 0.9 1.7 3.2 0.6 1.8 -1.8 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.8 0.9 0.4 -0.0 0.6
Falls in the last year 1.1 1.4 4.9 -2.2 0.9 0.2 0.2
Hair/balding pattern: Pattern 3 0.3 0.5 0.8 -0.3 0.9 -0.8 -0.6
Number of live births 0.9 1.2 3.0 0.9 0.7 0.7 1.7
Forced expiratory volume in 1-second (FEV1) 0.9 3.1 10.8 0.2 3.3 -0.6 1.1
Pulse rate 0.7 1.2 1.8 0.8 1.4 1.0 1.2
Happiness 1.0 1.2 1.6 1.2 -0.7 1.2 1.2
Noisy workplace 0.3 0.4 1.2 0.2 -0.3 0.4 1.1
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.3 1.1 1.1 0.5 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 3.0 0.4 1.7 0.5 -0.6
Mouth/teeth dental problems: Dentures 0.4 0.7 1.3 1.1 -1.2 -0.6 -0.2
Asthma 0.5 1.0 2.3 -1.5 -0.7 -0.1 -1.1
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.7 5.6 2.0 -0.7 0.8 2.4
Medication: Cholesterol lowering 1.3 2.0 5.8 -2.4 0.8 -0.7 -1.0
Depression (self-reported) 0.9 1.1 2.6 -0.2 -1.6 -1.0 -0.8
Medication: Lansoprazole 1.0 1.2 2.7 -1.4 0.2 -0.2 -1.6
Prospective memory result 0.5 0.6 1.9 0.1 1.4 0.5 -0.5
Lung cancer (father) 1.1 1.2 2.3 1.5 1.5 -0.2 0.7
Illnesses of mother 1.0 1.3 3.2 1.8 -0.2 0.8 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 6.2 0.4 2.5 0.1 2.0
Pulse wave Arterial Stiffness index 0.6 0.7 2.0 -1.4 0.3 -0.8 -0.1
Impedance of arm (left) 0.4 1.6 3.2 1.2 -1.3 -0.2 1.8
Arm fat mass (right) 0.3 1.1 1.4 -1.2 1.1 0.9 -1.1
Trunk predicted mass 0.2 1.1 1.8 -1.3 1.1 0.5 -1.1
Standing height 0.0 0.5 0.8 0.8 -0.1 0.9 0.6
Length of working week for main job 0.9 1.0 1.5 1.2 -0.1 1.0 1.2
Exposure to tobacco smoke at home 0.2 0.2 0.4 0.6 -0.6 0.1 -0.1
Breastfed as a baby 0.2 0.2 0.5 0.1 -0.6 -0.7 0.4
Tense / ‘highly strung’ 0.2 0.3 0.8 0.9 -0.1 -0.5 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 6.7 -1.2 1.3 -2.6 -1.3
Hair/balding pattern: Pattern 4 0.4 0.9 2.5 -0.9 1.6 0.1 -0.7
Birth weight of first child 0.4 0.8 1.3 -1.1 -0.4 -1.1 0.7
Peak expiratory flow (PEF) 0.2 0.4 1.5 -0.0 1.2 -0.3 0.1
Pulse wave reflection index 1.2 1.5 2.8 -1.7 -0.3 -1.4 -1.1
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.8 -0.2 -0.9 0.4 -0.4
Loud music exposure frequency 0.3 0.3 0.8 -0.9 0.0 -0.3 -0.7
Qualifications: O levels/GCSEs or equivalent 2.0 3.1 6.2 2.5 0.8 2.2 0.8
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 4.8 0.3 2.2 -1.4 -0.2
Blood clot in the leg (DVT) 0.2 0.3 0.7 0.8 0.3 0.4 0.6
Medication: Paracetamol 0.6 1.0 3.4 -0.1 0.7 0.1 1.8
Headache pain in last month 0.1 0.2 0.6 -0.1 0.8 -0.3 0.2
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.3 1.5 0.7 -1.0 0.0
Glaucoma (self-reported) 0.8 0.9 3.4 1.9 0.3 0.3 -0.3
Gout (self-reported) 2.3 3.2 7.0 -2.7 0.1 -1.9 -1.5
Hypothyroidism/myxoedema (self-reported) 1.6 3.1 7.7 -2.8 1.2 -1.1 -1.4
Medication: Amlodipine 0.2 0.3 0.7 0.2 -0.8 0.7 -0.3
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.4 0.2 -0.6 -1.6 -0.8
Birth weight 0.6 1.3 3.4 0.3 1.2 0.5 1.8
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.9 -0.5 0.5 1.4 0.5
High blood pressure (siblings) 0.6 0.8 2.9 -0.6 0.0 -1.7 0.2
Forced vital capacity (FVC), Best measure 0.9 3.2 8.4 0.2 2.9 -0.4 2.1
Body fat percentage 0.2 0.7 1.6 -0.3 0.8 1.3 -0.7
Leg fat percentage (right) 0.4 1.6 2.3 -0.4 1.5 1.5 -1.3
Arm fat-free mass (right) 0.2 1.0 1.6 -1.1 0.7 0.8 -1.3
Exposure to tobacco smoke outside home 0.7 1.0 1.8 1.3 0.3 1.0 1.0
Comparative body size at age 10 0.4 1.1 3.4 0.3 -0.4 1.9 0.8
Number of full brothers 0.1 0.1 0.2 -0.3 -0.1 -0.4 0.4
Worry too long after embarrassment 1.0 1.6 3.6 0.1 1.4 -1.9 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 3.8 4.9 11.0 -2.0 -0.5 -3.3 -2.1
Wheeze or whistling in the chest in last year 0.1 0.2 0.5 0.2 0.1 -0.7 0.6
Number of children fathered 0.3 0.3 1.0 0.6 1.0 -0.1 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.6 3.2 -1.5 0.9 -1.8 -0.0
Age at first live birth 1.1 1.9 2.9 -0.9 -1.6 1.2 1.7
Pulse wave peak to peak time 0.6 0.7 2.1 1.4 -0.6 0.7 0.0
Health satisfaction 0.5 0.6 1.3 -0.6 0.2 0.9 1.1
Shortness of breath walking on level ground 0.1 0.1 0.2 0.4 0.2 0.5 -0.3
Qualifications: College or University degree 0.4 1.2 3.5 -0.5 -1.9 -0.7 -0.6
Eye problems/disorders: None of the above 0.8 1.0 3.1 -1.8 0.6 -0.5 -0.4
Mouth/teeth dental problems: Loose teeth 1.0 1.2 4.5 0.2 2.1 -0.5 -0.0
Emphysema/chronic bronchitis 0.3 0.4 0.9 1.0 -0.2 -0.6 0.4
Medication for pain relief, constipation, heartburn 0.2 0.4 1.1 -0.3 -0.1 -0.7 -1.0
Neck or shoulder pain in last month 0.7 0.9 1.5 0.8 1.2 0.7 1.0
Medication: Blood pressure 0.9 1.5 2.5 -0.6 -1.3 1.3 1.6
Angina (self-reported) 1.4 1.9 5.1 -2.3 -0.4 -1.5 -0.2
Migraine (self-reported) 0.2 0.2 0.6 -0.3 -0.2 -0.8 0.3
Medication: Ibuprofen 2.3 2.7 5.1 2.1 -0.2 1.1 2.3
Medication: Allopurinol 1.1 1.4 3.9 -2.0 -0.3 -0.7 -1.1
Medication: Omeprazole 0.5 0.6 1.1 -0.8 0.2 -1.0 -0.9
Medication: Seretide 50 evohaler 1.8 2.0 4.8 1.6 -0.4 2.2 0.8
Mean time to correctly identify matches 1.4 2.7 3.7 1.9 0.9 1.8 1.7
Heart disease (mother) 0.8 0.9 1.5 -1.2 0.4 -1.1 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 4.6 -0.0 0.0 2.1 0.3
Whole body fat mass 0.2 0.8 1.4 -0.7 0.8 1.2 -0.8
Leg fat mass (right) 0.3 1.2 1.7 -0.7 1.3 1.3 -0.9
Arm predicted mass (right) 0.2 0.8 1.0 -0.7 0.9 1.0 -1.0
Pulse rate, automated reading 0.4 1.4 2.7 0.7 1.3 1.6 0.8
Alcohol intake frequency. 0.4 0.8 2.6 -0.5 1.6 0.5 -0.6
Comparative height size at age 10 0.1 0.8 1.0 1.0 -0.7 0.8 1.0
Number of full sisters 0.4 0.5 1.8 -0.1 1.3 -0.1 0.4
Suffer from ‘nerves’ 0.3 0.5 1.1 1.1 -0.7 -0.3 0.4
Overall health rating 0.3 0.7 1.5 -1.0 0.4 -0.3 1.2
Chest pain or discomfort 0.4 0.6 2.1 -0.2 0.5 -1.4 -0.3
Had major operations 0.8 0.9 2.2 0.9 1.5 0.2 0.8
Age at last live birth 1.8 2.5 7.5 -0.5 -1.3 0.9 2.7
Family relationship satisfaction 0.8 1.0 1.0 1.0 -1.0 0.9 1.0
Leg pain on walking 0.7 0.8 2.1 0.8 1.4 0.8 0.0
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.6 3.7 1.0 -0.9 1.0 1.9
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.6 0.5 0.8 -0.2 -0.1
Illness, injury, bereavement, stress in last 2 years 2.2 2.7 5.8 -1.8 0.0 -2.4 -1.4
Medication: Aspirin 1.5 2.0 3.9 -2.0 -0.7 -1.1 -1.5
Supplements: Vitamin C 0.8 1.0 3.6 0.4 -0.2 1.9 -0.0
Knee pain experienced in last month 1.1 1.6 3.4 0.7 -1.1 1.2 1.9
Hypertension (Self-reported) 0.6 1.7 4.4 -2.1 -1.5 -0.3 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.7 3.1 5.2 -1.7 0.9 -1.9 -2.3
Illnesses of father: Heart disease 0.7 1.0 2.1 -1.4 0.2 -1.0 -0.9
Illnesses of siblings: Diabetes 0.5 0.6 1.4 0.5 1.2 0.2 0.8
Smoking status: Previous 0.2 0.3 0.7 0.5 -0.2 0.6 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 2.6 1.0 0.6 0.9 1.6
Whole body fat-free mass 0.2 0.9 1.3 -1.1 1.0 0.8 -0.8
Leg fat-free mass (right) 0.1 0.6 0.9 -0.8 0.9 0.8 -0.3
Arm fat percentage (left) 0.2 0.7 0.8 -0.9 0.9 0.7 -0.7
Average weekly red wine intake 0.4 0.6 2.0 -0.4 0.4 -0.2 -1.4
Handedness (chirality/laterality): Left-handed 1.2 1.5 3.7 1.9 -0.8 1.3 0.0
Mood swings 0.4 0.7 1.7 0.9 1.3 0.4 0.2
Loneliness, isolation 0.6 0.8 2.0 0.8 -0.3 0.7 1.4
Long-standing illness, disability or infirmity 0.6 1.0 1.9 1.2 -0.3 1.4 0.7
Ever had bowel cancer screening 0.5 0.6 1.7 1.3 0.2 0.7 0.2
Diabetes diagnosed by doctor 1.6 2.7 8.0 -0.5 2.8 -0.8 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.7 -0.8 1.3 -1.1 -0.5
Friendships satisfaction 0.3 0.3 0.9 0.9 -0.0 0.6 0.1
Qualifications: nursing, teaching 1.7 2.7 4.9 1.4 -2.2 1.8 1.0
Commuting to job workplace: Walk 0.7 0.8 1.4 -1.1 -0.6 0.4 -1.2
Eye problems/disorders: Cataract 0.5 0.6 1.0 0.9 -1.0 0.2 0.9
Mouth/teeth dental problems: Mouth ulcers 1.6 2.5 4.3 0.8 2.1 -1.9 -1.2
Medication for cholesterol 0.2 0.3 0.6 0.1 0.7 -0.8 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 4.1 -1.0 2.0 0.2 0.3
Back pain experienced in last month 4.3 6.3 8.2 2.8 2.5 1.8 2.9
Mineral and other dietary supplements 0.2 0.3 0.4 0.6 -0.6 0.3 0.6
Breast cancer (self-reported) 0.6 0.7 1.4 -0.6 -0.9 -0.4 -1.2
Asthma (self-reported) 0.5 1.1 2.4 -1.5 -0.9 -0.2 -1.0
Osteoporosis (self-reported) 1.5 1.9 4.2 2.1 -1.2 0.7 1.1
Osteoarthritis (self-reported) 1.0 1.3 4.1 0.8 0.1 0.6 2.0
Medication: Aspirin 2.3 2.9 4.8 -2.2 -0.6 -1.3 -2.2
Medication: Gliclazide 1.9 2.1 6.7 -1.1 2.6 -0.3 -0.8
Illnesses of father: None of the above (group 1) 0.4 0.5 1.4 1.2 -0.1 0.7 -0.4
Smoking status: Current 0.7 1.1 2.8 -0.5 0.1 -1.7 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 4.0 -0.2 2.0 -0.5 0.1
Whole body water mass 0.2 0.9 1.2 -1.1 1.0 0.8 -0.8
Leg predicted mass (right) 0.1 0.5 0.8 -0.8 0.9 0.7 -0.4
Arm fat mass (left) 0.2 1.0 1.3 -1.1 1.0 0.8 -1.0
Number of self-reported non-cancer illnesses 0.2 0.3 0.7 -0.5 0.8 0.2 -0.4
Average weekly champagne plus white wine intake 1.0 1.4 2.3 -1.5 -1.5 -0.3 -1.1
Miserableness 0.4 0.7 1.5 1.2 1.0 -0.4 0.1
Guilty feelings 1.7 2.6 4.9 0.5 -2.2 0.6 2.2
Wears glasses or contact lenses 3.2 3.7 5.7 0.4 -1.8 2.4 2.4
Ever taken oral contraceptive pill 0.3 0.3 0.8 -0.9 0.3 0.3 -0.5
Hearing aid user 0.7 0.8 3.0 -0.3 -1.7 0.2 -0.2
Mother’s age at death 0.3 0.4 1.0 1.0 0.7 -0.0 -0.5
Financial situation satisfaction 0.5 0.7 0.9 -1.0 -0.9 0.6 0.7
Tinnitus: Yes, now most or all of the time 1.4 1.7 5.9 0.3 -0.5 0.6 2.4
Commuting to job workplace: Public transport 0.9 1.0 1.6 1.2 -1.3 0.6 0.8
Eye problems/disorders: Glaucoma 0.3 0.4 1.1 1.1 -0.1 0.5 0.0
Medication: Blood pressure 0.5 0.9 1.2 -0.6 -1.1 -1.0 -0.9
Pain type(s) experienced in last month: Hip pain 2.9 3.7 5.0 2.2 1.4 1.8 2.1
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.7 0.0 0.6 0.9 0.2
High cholesterol (Self-reported) 0.1 0.3 0.6 -0.6 0.8 0.1 -0.4
Medication: Bendroflumethiazide 1.3 2.0 6.1 -0.6 -0.9 -2.5 -0.8
Medication: Paracetamol 1.1 1.7 3.2 0.4 1.8 0.9 1.6
Medication: Lisinopril 0.4 0.5 0.6 0.7 -0.7 0.7 0.7
Medication: Atorvastatin 2.0 2.4 7.6 -2.7 -0.3 -1.3 -0.6
Illnesses of father: High blood pressure 1.6 2.0 6.2 -1.0 -0.3 -2.5 -0.7
Alcohol drinker status: Never 0.3 0.4 0.8 0.7 0.9 -0.6 -0.1
Ever smoked 0.4 0.8 1.2 -0.1 -0.9 -1.1 -1.1
Basal metabolic rate 0.2 0.9 1.1 -1.0 1.0 0.9 -0.8
Leg fat percentage (left) 0.5 1.7 3.5 -0.2 1.3 1.9 -1.2
Arm fat-free mass (left) 0.2 0.8 1.6 -0.6 0.8 1.3 -0.8
Number of operations (self-reported) 0.3 0.4 0.9 -0.1 0.6 0.5 0.9
Average weekly beer plus cider intake 0.3 0.5 1.7 -0.2 1.3 0.3 0.1
Irritability 0.1 0.2 0.6 0.3 0.1 0.2 -0.8
Risk taking 1.0 1.5 3.0 -1.2 1.2 -0.3 -1.7
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.1 0.2 -0.7 0.2 -1.0
Fractured/broken bones in last 5 years 0.6 0.7 2.7 -0.1 -1.6 0.3 0.2
Age started oral contraceptive pill 0.3 0.4 0.9 -0.9 -0.6 0.3 0.5
Diastolic blood pressure, automated reading 1.6 5.1 14.6 -1.9 -3.8 -1.5 -0.4
Ever depressed for a whole week 0.4 0.4 1.2 -0.4 0.5 -1.1 -0.5
Unable to work because of sickness or disability 0.1 0.2 0.4 -0.6 -0.3 0.3 0.4
Commuting to job workplace: Cycle 4.5 5.5 10.6 -1.7 2.0 -2.1 -3.3
Myopia 0.2 0.3 0.4 -0.5 0.6 -0.6 -0.6
Vascular/heart problems diagnosed by doctor 0.7 1.8 3.7 1.8 1.9 0.4 -0.2
Cholesterol lowering medication 0.7 1.1 2.4 -1.5 1.0 -0.2 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.1 -0.4 0.4 -0.9 -1.0
Pain experienced in last month 0.9 1.5 2.5 -1.3 -1.3 -0.5 -1.6
Supplements: Calcium 0.5 0.5 1.1 -1.0 -0.8 -0.4 -0.5
Basal cell carcinoma (self-reported) 0.3 0.3 1.0 -0.2 -0.5 0.1 -1.0
Heart attack/myocardial infarction (self-reported) 2.2 2.9 5.9 -1.2 1.0 -1.7 -2.4
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.6 0.8 0.2 0.2 0.7
Heart disease (siblings) 0.1 0.1 0.4 0.1 0.3 -0.0 0.6
Alcohol drinker status: Previous 1.2 1.3 2.7 -1.6 -0.4 -1.1 -1.1
Pack years of smoking 0.3 0.5 1.2 0.6 -1.1 0.5 -0.1
Impedance of whole body 0.5 2.3 3.7 1.9 -1.4 0.1 1.9
Leg fat mass (left) 0.3 1.3 2.6 -0.8 1.1 1.6 -0.8
Arm predicted mass (left) 0.2 1.0 1.4 -0.9 0.9 1.2 -1.1