Hub : Genes

PLAGL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.0750	0.0310	7.3e-03	0.023	NA	0.012	NA	0.017	3.3e-03	NA	2.6e-02	NA	9.7e-03
2	METSIM	Adipose	0.0306	0.0140	7.1e-03	0.015	0.007	0.000	0.006	0.009	2.3e-03	3.0e-02	2.6e-01	3.2e-02	1.4e-02
3	NTR	Blood	0.0416	0.0111	2.8e-07	0.005	0.025	0.019	0.025	0.016	5.3e-03	1.1e-08	5.9e-07	9.2e-09	4.7e-06
4	YFS	Blood	0.1937	0.0293	0.0e+00	0.068	0.115	0.145	0.128	0.143	3.5e-21	1.1e-35	3.2e-45	8.3e-40	2.9e-44

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.7	3.1	-1.2	1.3	-1.8	-0.6
Bipolar Disorder or Schizophrenia	0.5	1.1	2.0	-0.8	1.0	-1.4	-1.0
Depressed Affect (Nagel 2018)	0.3	0.6	1.3	1.1	0.3	0.2	1.1
Depression (Nagel 2018)	1.0	1.4	2.5	-1.6	-1.5	-1.0	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	-0.7	0.6	-0.1	-0.1
Neuroticism (Nagel 2018)	0.3	0.7	1.9	0.3	0.9	-1.4	0.2
Schizophrenia (2018)	0.1	0.2	0.6	-0.1	0.2	-0.4	-0.8
Schizophrenia vs Biploar Disorder	0.5	0.6	1.4	1.2	-0.1	1.0	-0.1
Worry (Nagel 2018)	0.3	0.7	1.9	0.9	-0.2	-1.4	-0.2
Alzheimer’s Disease (in mother)	2.2	2.6	5.7	2.4	0.4	1.9	0.9
Alzheimer’s Disease (in father)	2.4	2.6	7.8	0.0	-2.8	-0.8	1.4
Alzheimer’s Disease (including proxy)	0.7	1.1	1.6	1.2	-1.3	0.4	1.1
Crohns Disease (2017)	0.6	1.2	3.8	0.9	-0.3	0.4	-2.0
Irritable Bowel Disease (IBD)	0.7	1.7	3.0	1.7	0.8	1.6	-0.9
Ulcerative Colitis (UC)	1.5	2.8	5.3	2.1	1.1	2.3	0.2
Major Depression (MDD)	5.5	6.7	8.5	-2.5	2.9	-2.9	-2.0
Reaction Time	0.8	1.6	3.2	1.4	0.5	1.0	1.8
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.3	0.5	-0.1	0.1
Breast Cancer	0.6	1.3	2.1	-1.3	-1.2	-0.2	-1.4
Ovarian Cancer	0.3	0.4	1.2	-0.5	-0.1	-0.2	-1.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.3	1.0	0.5	-0.2	1.0	0.0
Bipolar Disorder (2011)	1.0	1.0	2.7	-0.9	0.1	-1.6	-0.6
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.3	0.3	0.1	-0.4
Coronary Artery Disease (CAD)	0.4	0.5	1.2	0.7	-1.1	0.5	-0.3
Crohns Disease (2012)	0.2	0.3	1.1	-0.1	0.0	-0.1	-1.1
Mean Putamen Volume	0.5	0.5	1.3	0.9	-1.1	-0.2	-0.3
Fasting Glucose	0.2	0.2	0.4	-0.3	-0.3	-0.7	0.4
HbA1C	0.3	0.4	1.0	0.3	1.0	0.7	0.0
HDL Cholesterol	0.7	1.1	2.0	1.0	-0.1	-1.2	-1.4
LDL Cholesterol	0.0	0.1	0.1	-0.1	-0.4	-0.0	0.3
Lupus	1.7	2.6	4.5	1.6	-2.1	0.4	1.8
Neuroticism (2016)	0.2	0.2	1.0	-0.0	1.0	0.2	-0.0
Primary Biliary Cirrhosis	0.2	0.2	0.6	0.7	0.4	0.3	-0.4
Rheumatoid Arthritis	0.6	0.8	1.9	-0.7	-0.7	0.8	1.4
Schizophrenia (2014)	0.4	0.9	2.8	-0.4	0.3	-0.7	-1.7
Triglycerides	0.5	0.9	3.2	-1.8	0.5	-0.3	-0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.1	-1.0	0.4	-1.0	-0.9
Ulcerative Colitis	2.3	3.4	6.6	2.6	1.1	2.4	0.2
Blood Eosinophil Count	1.3	10.3	16.8	3.0	-2.1	3.3	4.1
Blood Platelet Count	0.3	3.0	10.7	0.3	-3.3	0.6	0.8
Blood Red Count	0.5	4.8	8.4	1.8	-1.7	2.9	2.1
Blood White Count	0.1	0.4	1.0	-0.1	0.1	-1.0	-0.7
Heel T-Score	0.1	0.6	1.8	-0.0	-0.1	0.8	1.4
BMI	0.2	1.2	2.0	-1.4	0.6	1.1	-1.1
Height	0.1	1.0	1.7	0.9	1.2	-0.1	1.3
Waist Hip Ratio (WHR)	0.5	2.4	4.7	0.7	-2.2	1.4	1.5
Systolic Blood Pressure	0.4	2.1	6.9	-1.0	-2.6	0.1	0.7
Smoking Status	0.4	0.9	1.9	0.2	-0.4	-1.4	-1.2
Allergy or Eczema	0.2	0.5	1.1	-0.4	1.1	-0.5	-0.5
Cardiovascular Disease	1.3	4.4	12.0	-3.5	-1.6	-1.6	-0.8
Hypothyroidism (self reported)	1.0	2.3	8.0	-2.8	0.4	-0.4	-1.0
Respiratory disease	0.1	0.1	0.3	0.5	-0.3	0.5	-0.1
Type 2 Diabetes (T2D) (2018)	1.1	2.1	6.8	-0.9	2.6	0.2	-0.8
Lung FEV1/FVC ratio	0.2	0.8	2.6	1.6	-0.7	0.3	0.1
Lung FVC	2.1	10.9	35.0	-1.3	5.9	-2.6	0.4
Neuroticism	0.2	0.5	1.8	1.4	0.5	-0.3	0.2
Chronotype (morning person)	0.8	1.9	4.6	1.2	2.2	1.2	-0.2
Hair Pigment	0.1	3.2	5.0	1.9	-0.1	2.0	2.2
Tanning	0.2	2.0	3.6	-1.1	1.8	-0.3	-1.9
Hand grip strength (left)	0.5	1.3	4.1	-0.6	-2.0	-0.4	-0.9
Number of treatments/medications taken	0.8	1.4	4.2	-0.3	1.0	2.0	0.6
Average weekly spirits intake	0.6	0.7	2.3	-0.4	0.1	1.5	0.6
Sensitivity / hurt feelings	2.3	3.9	9.7	-0.7	2.2	-3.1	-0.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	-0.6	0.0	-0.1	1.0
Hearing difficulty/problems: Yes	0.6	0.9	1.2	-1.0	1.1	-0.6	-1.0
Relative age of first facial hair	0.3	0.5	0.9	-0.5	-1.0	0.2	0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.0	0.9	-0.5	1.0	0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.1	-1.0	1.2	1.8	-0.3
Ever had hysterectomy (womb removed)	0.7	0.8	2.3	-1.5	-0.3	-0.9	0.1
Systolic blood pressure, automated reading	1.0	3.0	4.7	-1.9	-2.2	-1.4	-1.3
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	2.9	1.7	1.4	1.1	-0.5
Angina	1.5	2.0	5.1	-2.2	-0.4	-1.6	-0.0
Medication for hormone replacement therapy	0.5	0.6	1.5	-0.1	0.5	1.2	-0.8
Vitamin and mineral supplements	1.0	1.4	4.8	-0.0	-2.2	-0.9	0.1
Supplements: Zinc	0.3	0.4	0.7	-0.8	0.8	-0.4	-0.0
Medication: Co-codamol	0.2	0.3	0.7	-0.4	0.4	-0.3	-0.8
Medication: Metformin	2.1	2.9	11.0	0.3	3.3	0.7	-0.1
Diabetes (father)	1.0	1.3	2.6	0.9	1.0	1.6	0.9
Diabetes (mother)	0.4	0.4	1.1	-0.1	1.1	0.4	-0.7
Severe depression (siblings)	0.2	0.2	0.2	0.5	0.4	-0.5	-0.4
Pack years adult smoking proportion	0.4	0.5	1.2	0.9	-1.1	0.4	-0.1
Impedance of leg (right)	0.2	0.9	1.8	1.3	-1.0	0.2	0.8
Leg fat-free mass (left)	0.1	0.7	1.1	-1.1	1.1	0.7	-0.4
Trunk fat percentage	0.1	0.4	1.0	-0.4	0.4	1.0	-0.5
Hand grip strength (right)	0.3	0.8	1.4	-0.8	-1.2	-0.1	-1.0
Townsend deprivation index at recruitment	0.8	1.1	3.4	-0.6	-0.3	-1.8	-0.8
Current tobacco smoking	0.3	0.4	1.4	-0.1	0.0	-1.2	-0.6
Average weekly fortified wine intake	0.8	0.9	2.0	-0.5	-1.4	0.1	-1.2
Maternal smoking around birth	0.4	0.6	1.3	-1.0	-0.2	-1.2	0.1
Fed-up feelings	0.2	0.4	0.6	0.5	0.6	-0.6	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.9	0.2	-1.2	-0.1	1.7
Relative age voice broke	0.6	0.8	2.6	0.5	-0.6	0.3	1.6
Taking other prescription medications	0.5	0.8	1.7	-0.6	0.9	0.7	-1.3
Age when periods started (menarche)	0.1	0.3	0.5	0.0	0.5	0.6	0.7
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.8	-1.3	0.5	-0.6	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.1	-0.7	1.0	-1.0	0.6
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	0.8	0.7	0.9	0.9	0.9
Qualifications: CSEs or equivalent	0.7	0.9	1.6	0.7	1.3	0.3	1.2
Serious illness, injury or assault to yourself	0.4	0.5	1.4	-0.2	-1.2	0.7	0.2
High blood pressure	0.7	1.8	4.6	-1.6	-2.1	0.1	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.7	-0.1	0.8	0.3	-0.7
Multivitamins +/- minerals	1.1	1.4	5.1	-0.2	2.3	0.1	-0.5
Stomach or abdominal pain in last month	0.7	0.8	1.5	1.2	1.2	0.5	0.4
Supplements: Glucosamine	1.8	2.4	8.3	-0.7	2.9	0.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.7	0.0	0.8	0.4	0.4
Medication: Atenolol	0.8	1.0	3.0	0.4	1.7	0.9	0.3
Medication: Levothyroxine sodium	1.0	1.8	3.9	-2.0	1.2	-0.8	-1.0
Sitting height	0.1	0.9	1.8	0.4	1.4	0.2	1.2
Chronic bronchitis/emphysema (father)	0.0	0.0	0.2	0.4	0.1	0.0	-0.1
High blood pressure (mother)	2.2	3.1	5.3	-2.3	0.5	-1.9	-1.8
Body mass index (BMI)	0.3	1.5	1.8	-1.2	1.3	0.9	-1.4
Impedance of leg (left)	0.3	1.4	2.6	1.6	-1.2	0.7	1.0
Leg predicted mass (left)	0.1	0.7	1.3	-1.1	1.0	0.7	-0.4
Trunk fat mass	0.2	0.7	1.7	-0.6	0.8	1.3	-0.6
Waist circumference	0.2	0.7	2.4	-0.2	0.4	1.6	-0.4
Number of incorrect matches in round	0.3	0.5	1.2	0.1	-0.5	-1.1	-0.8
Past tobacco smoking	0.0	0.1	0.3	-0.2	0.1	0.2	0.5
Alcohol usually taken with meals	1.2	2.0	3.6	-0.4	1.9	1.0	-1.8
Nervous feelings	0.4	0.8	1.4	1.1	1.2	-0.4	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	-0.1	0.3	-0.8	0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.2	0.2	-0.7	-0.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	0.4	0.5	-0.6	1.1
Had menopause	1.0	1.3	2.3	-1.2	1.2	-0.3	-1.5
Had other major operations	2.2	2.7	4.0	-2.0	0.8	-1.8	-1.7
Forced vital capacity (FVC)	1.0	4.0	12.2	0.4	3.5	-0.7	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.5	-1.1	0.3	-1.6	-0.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	-0.5	-0.8	-1.1	-0.6
Qualifications: None of the above	0.3	0.5	0.9	0.7	0.8	0.9	0.3
Financial difficulties in last 2 years	0.2	0.3	1.0	-0.0	1.0	-0.4	0.1
Mouth/teeth dental problems	0.9	1.3	3.0	-0.8	-1.1	1.7	0.6
Heart attack	1.8	2.4	5.5	-1.2	0.8	-1.4	-2.4
Allergy	0.1	0.3	0.7	0.6	-0.1	0.3	0.8
Pain all over the body in last month	0.1	0.1	0.2	-0.3	-0.4	0.1	0.1
Diabetes (self-reported)	1.1	1.7	5.7	-0.2	2.4	-0.4	-0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.3	1.1	-0.1	1.1	-0.4
Medication: Ramipril	1.4	1.9	5.1	-1.0	1.1	-0.5	-2.3
Medication: Simvastatin	0.9	1.4	3.4	-1.0	1.9	-0.4	-1.0
Fluid intelligence score	0.1	0.3	0.5	-0.4	-0.7	0.3	0.5
Illnesses of siblings	0.4	0.5	0.8	0.9	0.4	0.9	-0.5
Neuroticism score	0.2	0.5	1.1	1.0	0.4	-0.5	0.6
Weight	0.2	1.2	2.2	-0.6	1.2	1.5	-1.0
Impedance of arm (right)	0.3	1.5	3.1	1.3	-1.1	-0.3	1.7
Arm fat percentage (right)	0.2	0.7	1.2	-0.8	1.1	0.8	-0.6
Trunk fat-free mass	0.2	1.1	1.4	-1.2	1.2	0.6	-1.1
Hip circumference	0.2	1.0	1.4	-0.7	1.2	0.8	-1.2
Time employed in main current job	0.5	0.6	0.8	0.9	0.9	0.8	0.5
Alcohol intake versus 10 years previously	0.5	0.7	1.9	1.4	0.2	0.8	-0.4
Father’s age at death	0.3	0.4	1.0	1.0	0.6	0.0	0.1
Worrier / anxious feelings	0.9	1.7	3.2	0.6	1.8	-1.8	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	0.9	0.4	-0.0	0.6
Falls in the last year	1.1	1.4	4.9	-2.2	0.9	0.2	0.2
Hair/balding pattern: Pattern 3	0.3	0.5	0.8	-0.3	0.9	-0.8	-0.6
Number of live births	0.9	1.2	3.0	0.9	0.7	0.7	1.7
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	10.8	0.2	3.3	-0.6	1.1
Pulse rate	0.7	1.2	1.8	0.8	1.4	1.0	1.2
Happiness	1.0	1.2	1.6	1.2	-0.7	1.2	1.2
Noisy workplace	0.3	0.4	1.2	0.2	-0.3	0.4	1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	1.1	1.1	0.5	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.0	0.4	1.7	0.5	-0.6
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	1.1	-1.2	-0.6	-0.2
Asthma	0.5	1.0	2.3	-1.5	-0.7	-0.1	-1.1
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	5.6	2.0	-0.7	0.8	2.4
Medication: Cholesterol lowering	1.3	2.0	5.8	-2.4	0.8	-0.7	-1.0
Depression (self-reported)	0.9	1.1	2.6	-0.2	-1.6	-1.0	-0.8
Medication: Lansoprazole	1.0	1.2	2.7	-1.4	0.2	-0.2	-1.6
Prospective memory result	0.5	0.6	1.9	0.1	1.4	0.5	-0.5
Lung cancer (father)	1.1	1.2	2.3	1.5	1.5	-0.2	0.7
Illnesses of mother	1.0	1.3	3.2	1.8	-0.2	0.8	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.2	0.4	2.5	0.1	2.0
Pulse wave Arterial Stiffness index	0.6	0.7	2.0	-1.4	0.3	-0.8	-0.1
Impedance of arm (left)	0.4	1.6	3.2	1.2	-1.3	-0.2	1.8
Arm fat mass (right)	0.3	1.1	1.4	-1.2	1.1	0.9	-1.1
Trunk predicted mass	0.2	1.1	1.8	-1.3	1.1	0.5	-1.1
Standing height	0.0	0.5	0.8	0.8	-0.1	0.9	0.6
Length of working week for main job	0.9	1.0	1.5	1.2	-0.1	1.0	1.2
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.6	-0.6	0.1	-0.1
Breastfed as a baby	0.2	0.2	0.5	0.1	-0.6	-0.7	0.4
Tense / ‘highly strung’	0.2	0.3	0.8	0.9	-0.1	-0.5	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	6.7	-1.2	1.3	-2.6	-1.3
Hair/balding pattern: Pattern 4	0.4	0.9	2.5	-0.9	1.6	0.1	-0.7
Birth weight of first child	0.4	0.8	1.3	-1.1	-0.4	-1.1	0.7
Peak expiratory flow (PEF)	0.2	0.4	1.5	-0.0	1.2	-0.3	0.1
Pulse wave reflection index	1.2	1.5	2.8	-1.7	-0.3	-1.4	-1.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.8	-0.2	-0.9	0.4	-0.4
Loud music exposure frequency	0.3	0.3	0.8	-0.9	0.0	-0.3	-0.7
Qualifications: O levels/GCSEs or equivalent	2.0	3.1	6.2	2.5	0.8	2.2	0.8
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.8	0.3	2.2	-1.4	-0.2
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.8	0.3	0.4	0.6
Medication: Paracetamol	0.6	1.0	3.4	-0.1	0.7	0.1	1.8
Headache pain in last month	0.1	0.2	0.6	-0.1	0.8	-0.3	0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.3	1.5	0.7	-1.0	0.0
Glaucoma (self-reported)	0.8	0.9	3.4	1.9	0.3	0.3	-0.3
Gout (self-reported)	2.3	3.2	7.0	-2.7	0.1	-1.9	-1.5
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	7.7	-2.8	1.2	-1.1	-1.4
Medication: Amlodipine	0.2	0.3	0.7	0.2	-0.8	0.7	-0.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.4	0.2	-0.6	-1.6	-0.8
Birth weight	0.6	1.3	3.4	0.3	1.2	0.5	1.8
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.9	-0.5	0.5	1.4	0.5
High blood pressure (siblings)	0.6	0.8	2.9	-0.6	0.0	-1.7	0.2
Forced vital capacity (FVC), Best measure	0.9	3.2	8.4	0.2	2.9	-0.4	2.1
Body fat percentage	0.2	0.7	1.6	-0.3	0.8	1.3	-0.7
Leg fat percentage (right)	0.4	1.6	2.3	-0.4	1.5	1.5	-1.3
Arm fat-free mass (right)	0.2	1.0	1.6	-1.1	0.7	0.8	-1.3
Exposure to tobacco smoke outside home	0.7	1.0	1.8	1.3	0.3	1.0	1.0
Comparative body size at age 10	0.4	1.1	3.4	0.3	-0.4	1.9	0.8
Number of full brothers	0.1	0.1	0.2	-0.3	-0.1	-0.4	0.4
Worry too long after embarrassment	1.0	1.6	3.6	0.1	1.4	-1.9	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	3.8	4.9	11.0	-2.0	-0.5	-3.3	-2.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.2	0.1	-0.7	0.6
Number of children fathered	0.3	0.3	1.0	0.6	1.0	-0.1	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	3.2	-1.5	0.9	-1.8	-0.0
Age at first live birth	1.1	1.9	2.9	-0.9	-1.6	1.2	1.7
Pulse wave peak to peak time	0.6	0.7	2.1	1.4	-0.6	0.7	0.0
Health satisfaction	0.5	0.6	1.3	-0.6	0.2	0.9	1.1
Shortness of breath walking on level ground	0.1	0.1	0.2	0.4	0.2	0.5	-0.3
Qualifications: College or University degree	0.4	1.2	3.5	-0.5	-1.9	-0.7	-0.6
Eye problems/disorders: None of the above	0.8	1.0	3.1	-1.8	0.6	-0.5	-0.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.5	0.2	2.1	-0.5	-0.0
Emphysema/chronic bronchitis	0.3	0.4	0.9	1.0	-0.2	-0.6	0.4
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	-0.3	-0.1	-0.7	-1.0
Neck or shoulder pain in last month	0.7	0.9	1.5	0.8	1.2	0.7	1.0
Medication: Blood pressure	0.9	1.5	2.5	-0.6	-1.3	1.3	1.6
Angina (self-reported)	1.4	1.9	5.1	-2.3	-0.4	-1.5	-0.2
Migraine (self-reported)	0.2	0.2	0.6	-0.3	-0.2	-0.8	0.3
Medication: Ibuprofen	2.3	2.7	5.1	2.1	-0.2	1.1	2.3
Medication: Allopurinol	1.1	1.4	3.9	-2.0	-0.3	-0.7	-1.1
Medication: Omeprazole	0.5	0.6	1.1	-0.8	0.2	-1.0	-0.9
Medication: Seretide 50 evohaler	1.8	2.0	4.8	1.6	-0.4	2.2	0.8
Mean time to correctly identify matches	1.4	2.7	3.7	1.9	0.9	1.8	1.7
Heart disease (mother)	0.8	0.9	1.5	-1.2	0.4	-1.1	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.6	-0.0	0.0	2.1	0.3
Whole body fat mass	0.2	0.8	1.4	-0.7	0.8	1.2	-0.8
Leg fat mass (right)	0.3	1.2	1.7	-0.7	1.3	1.3	-0.9
Arm predicted mass (right)	0.2	0.8	1.0	-0.7	0.9	1.0	-1.0
Pulse rate, automated reading	0.4	1.4	2.7	0.7	1.3	1.6	0.8
Alcohol intake frequency.	0.4	0.8	2.6	-0.5	1.6	0.5	-0.6
Comparative height size at age 10	0.1	0.8	1.0	1.0	-0.7	0.8	1.0
Number of full sisters	0.4	0.5	1.8	-0.1	1.3	-0.1	0.4
Suffer from ‘nerves’	0.3	0.5	1.1	1.1	-0.7	-0.3	0.4
Overall health rating	0.3	0.7	1.5	-1.0	0.4	-0.3	1.2
Chest pain or discomfort	0.4	0.6	2.1	-0.2	0.5	-1.4	-0.3
Had major operations	0.8	0.9	2.2	0.9	1.5	0.2	0.8
Age at last live birth	1.8	2.5	7.5	-0.5	-1.3	0.9	2.7
Family relationship satisfaction	0.8	1.0	1.0	1.0	-1.0	0.9	1.0
Leg pain on walking	0.7	0.8	2.1	0.8	1.4	0.8	0.0
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	3.7	1.0	-0.9	1.0	1.9
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	0.5	0.8	-0.2	-0.1
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	5.8	-1.8	0.0	-2.4	-1.4
Medication: Aspirin	1.5	2.0	3.9	-2.0	-0.7	-1.1	-1.5
Supplements: Vitamin C	0.8	1.0	3.6	0.4	-0.2	1.9	-0.0
Knee pain experienced in last month	1.1	1.6	3.4	0.7	-1.1	1.2	1.9
Hypertension (Self-reported)	0.6	1.7	4.4	-2.1	-1.5	-0.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.1	5.2	-1.7	0.9	-1.9	-2.3
Illnesses of father: Heart disease	0.7	1.0	2.1	-1.4	0.2	-1.0	-0.9
Illnesses of siblings: Diabetes	0.5	0.6	1.4	0.5	1.2	0.2	0.8
Smoking status: Previous	0.2	0.3	0.7	0.5	-0.2	0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.6	1.0	0.6	0.9	1.6
Whole body fat-free mass	0.2	0.9	1.3	-1.1	1.0	0.8	-0.8
Leg fat-free mass (right)	0.1	0.6	0.9	-0.8	0.9	0.8	-0.3
Arm fat percentage (left)	0.2	0.7	0.8	-0.9	0.9	0.7	-0.7
Average weekly red wine intake	0.4	0.6	2.0	-0.4	0.4	-0.2	-1.4
Handedness (chirality/laterality): Left-handed	1.2	1.5	3.7	1.9	-0.8	1.3	0.0
Mood swings	0.4	0.7	1.7	0.9	1.3	0.4	0.2
Loneliness, isolation	0.6	0.8	2.0	0.8	-0.3	0.7	1.4
Long-standing illness, disability or infirmity	0.6	1.0	1.9	1.2	-0.3	1.4	0.7
Ever had bowel cancer screening	0.5	0.6	1.7	1.3	0.2	0.7	0.2
Diabetes diagnosed by doctor	1.6	2.7	8.0	-0.5	2.8	-0.8	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.7	-0.8	1.3	-1.1	-0.5
Friendships satisfaction	0.3	0.3	0.9	0.9	-0.0	0.6	0.1
Qualifications: nursing, teaching	1.7	2.7	4.9	1.4	-2.2	1.8	1.0
Commuting to job workplace: Walk	0.7	0.8	1.4	-1.1	-0.6	0.4	-1.2
Eye problems/disorders: Cataract	0.5	0.6	1.0	0.9	-1.0	0.2	0.9
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	4.3	0.8	2.1	-1.9	-1.2
Medication for cholesterol	0.2	0.3	0.6	0.1	0.7	-0.8	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.1	-1.0	2.0	0.2	0.3
Back pain experienced in last month	4.3	6.3	8.2	2.8	2.5	1.8	2.9
Mineral and other dietary supplements	0.2	0.3	0.4	0.6	-0.6	0.3	0.6
Breast cancer (self-reported)	0.6	0.7	1.4	-0.6	-0.9	-0.4	-1.2
Asthma (self-reported)	0.5	1.1	2.4	-1.5	-0.9	-0.2	-1.0
Osteoporosis (self-reported)	1.5	1.9	4.2	2.1	-1.2	0.7	1.1
Osteoarthritis (self-reported)	1.0	1.3	4.1	0.8	0.1	0.6	2.0
Medication: Aspirin	2.3	2.9	4.8	-2.2	-0.6	-1.3	-2.2
Medication: Gliclazide	1.9	2.1	6.7	-1.1	2.6	-0.3	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	1.2	-0.1	0.7	-0.4
Smoking status: Current	0.7	1.1	2.8	-0.5	0.1	-1.7	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.0	-0.2	2.0	-0.5	0.1
Whole body water mass	0.2	0.9	1.2	-1.1	1.0	0.8	-0.8
Leg predicted mass (right)	0.1	0.5	0.8	-0.8	0.9	0.7	-0.4
Arm fat mass (left)	0.2	1.0	1.3	-1.1	1.0	0.8	-1.0
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	-0.5	0.8	0.2	-0.4
Average weekly champagne plus white wine intake	1.0	1.4	2.3	-1.5	-1.5	-0.3	-1.1
Miserableness	0.4	0.7	1.5	1.2	1.0	-0.4	0.1
Guilty feelings	1.7	2.6	4.9	0.5	-2.2	0.6	2.2
Wears glasses or contact lenses	3.2	3.7	5.7	0.4	-1.8	2.4	2.4
Ever taken oral contraceptive pill	0.3	0.3	0.8	-0.9	0.3	0.3	-0.5
Hearing aid user	0.7	0.8	3.0	-0.3	-1.7	0.2	-0.2
Mother’s age at death	0.3	0.4	1.0	1.0	0.7	-0.0	-0.5
Financial situation satisfaction	0.5	0.7	0.9	-1.0	-0.9	0.6	0.7
Tinnitus: Yes, now most or all of the time	1.4	1.7	5.9	0.3	-0.5	0.6	2.4
Commuting to job workplace: Public transport	0.9	1.0	1.6	1.2	-1.3	0.6	0.8
Eye problems/disorders: Glaucoma	0.3	0.4	1.1	1.1	-0.1	0.5	0.0
Medication: Blood pressure	0.5	0.9	1.2	-0.6	-1.1	-1.0	-0.9
Pain type(s) experienced in last month: Hip pain	2.9	3.7	5.0	2.2	1.4	1.8	2.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	0.0	0.6	0.9	0.2
High cholesterol (Self-reported)	0.1	0.3	0.6	-0.6	0.8	0.1	-0.4
Medication: Bendroflumethiazide	1.3	2.0	6.1	-0.6	-0.9	-2.5	-0.8
Medication: Paracetamol	1.1	1.7	3.2	0.4	1.8	0.9	1.6
Medication: Lisinopril	0.4	0.5	0.6	0.7	-0.7	0.7	0.7
Medication: Atorvastatin	2.0	2.4	7.6	-2.7	-0.3	-1.3	-0.6
Illnesses of father: High blood pressure	1.6	2.0	6.2	-1.0	-0.3	-2.5	-0.7
Alcohol drinker status: Never	0.3	0.4	0.8	0.7	0.9	-0.6	-0.1
Ever smoked	0.4	0.8	1.2	-0.1	-0.9	-1.1	-1.1
Basal metabolic rate	0.2	0.9	1.1	-1.0	1.0	0.9	-0.8
Leg fat percentage (left)	0.5	1.7	3.5	-0.2	1.3	1.9	-1.2
Arm fat-free mass (left)	0.2	0.8	1.6	-0.6	0.8	1.3	-0.8
Number of operations (self-reported)	0.3	0.4	0.9	-0.1	0.6	0.5	0.9
Average weekly beer plus cider intake	0.3	0.5	1.7	-0.2	1.3	0.3	0.1
Irritability	0.1	0.2	0.6	0.3	0.1	0.2	-0.8
Risk taking	1.0	1.5	3.0	-1.2	1.2	-0.3	-1.7
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.1	0.2	-0.7	0.2	-1.0
Fractured/broken bones in last 5 years	0.6	0.7	2.7	-0.1	-1.6	0.3	0.2
Age started oral contraceptive pill	0.3	0.4	0.9	-0.9	-0.6	0.3	0.5
Diastolic blood pressure, automated reading	1.6	5.1	14.6	-1.9	-3.8	-1.5	-0.4
Ever depressed for a whole week	0.4	0.4	1.2	-0.4	0.5	-1.1	-0.5
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.6	-0.3	0.3	0.4
Commuting to job workplace: Cycle	4.5	5.5	10.6	-1.7	2.0	-2.1	-3.3
Myopia	0.2	0.3	0.4	-0.5	0.6	-0.6	-0.6
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.7	1.8	1.9	0.4	-0.2
Cholesterol lowering medication	0.7	1.1	2.4	-1.5	1.0	-0.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	-0.4	0.4	-0.9	-1.0
Pain experienced in last month	0.9	1.5	2.5	-1.3	-1.3	-0.5	-1.6
Supplements: Calcium	0.5	0.5	1.1	-1.0	-0.8	-0.4	-0.5
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	-0.2	-0.5	0.1	-1.0
Heart attack/myocardial infarction (self-reported)	2.2	2.9	5.9	-1.2	1.0	-1.7	-2.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.8	0.2	0.2	0.7
Heart disease (siblings)	0.1	0.1	0.4	0.1	0.3	-0.0	0.6
Alcohol drinker status: Previous	1.2	1.3	2.7	-1.6	-0.4	-1.1	-1.1
Pack years of smoking	0.3	0.5	1.2	0.6	-1.1	0.5	-0.1
Impedance of whole body	0.5	2.3	3.7	1.9	-1.4	0.1	1.9
Leg fat mass (left)	0.3	1.3	2.6	-0.8	1.1	1.6	-0.8
Arm predicted mass (left)	0.2	1.0	1.4	-0.9	0.9	1.2	-1.1