Hub : Genes

PLCG2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pancreas	0.4860	0.0910	1.6e-04	0.242	NA	0.228	NA	0.229	1.3e-10	NA	5.3e-10	NA	4.5e-10
2	GTEx	Skin Sun Exposed Lower leg	0.2670	0.0640	1.1e-04	0.006	NA	0.036	NA	0.030	1.0e-01	NA	5.9e-04	NA	1.4e-03
3	METSIM	Adipose	0.1395	0.0385	1.6e-04	0.038	0.040	0.050	0.043	0.023	1.8e-06	1.2e-06	4.6e-08	4.9e-07	1.6e-04
4	YFS	Blood	0.0706	0.0171	2.3e-07	0.027	0.028	0.060	0.055	0.067	2.5e-09	1.1e-09	8.0e-19	2.1e-17	4.5e-21
5	TCGA	Brain Lower Grade Glioma	0.1098	0.0321	5.6e-05	-0.002	0.037	0.009	NA	-0.001	7.3e-01	4.4e-05	3.1e-02	NA	5.4e-01
6	TCGA	Lung Squamous Cell Carcinoma	0.1014	0.0323	1.9e-04	-0.001	0.031	0.001	NA	0.000	4.8e-01	1.7e-04	2.2e-01	NA	3.7e-01
7	TCGA	Pancreatic Adenocarcinoma	0.2400	0.0830	3.0e-03	0.000	0.053	0.016	NA	-0.002	3.2e-01	3.0e-03	6.9e-02	NA	4.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	3.3	-0.4	0.6	-0.4	0.6	-1.8	-0.2	0.4
Bipolar Disorder or Schizophrenia	0.3	0.8	1.9	-0.6	0.6	-1.2	1.2	-1.4	-0.1	-0.7
Depressed Affect (Nagel 2018)	0.4	0.9	2.4	-1.0	-1.5	0.7	-1.6	-0.6	0.0	-0.1
Depression (Nagel 2018)	0.1	0.1	0.6	-0.8	-0.1	0.6	-0.2	0.1	0.1	0.2
Intelligence (Savage-Jansen 2018)	0.7	2.0	4.4	1.7	-1.9	-1.5	-2.1	-0.6	-0.5	0.3
Neuroticism (Nagel 2018)	0.3	0.8	2.6	-1.0	-0.6	1.6	-0.9	0.2	0.2	0.7
Schizophrenia (2018)	0.3	0.7	1.7	-0.4	0.4	-1.3	1.1	-0.2	0.0	-1.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	0.0	-0.4	-1.1	0.4	0.8	-0.3	-0.7
Worry (Nagel 2018)	0.4	0.9	2.2	-1.3	0.4	1.5	0.2	0.7	0.2	1.4
Alzheimer’s Disease (in mother)	1.3	1.5	4.5	0.8	-0.8	0.3	1.4	-1.7	-2.1	-0.1
Alzheimer’s Disease (in father)	0.7	0.7	1.7	-0.7	0.0	-1.2	-0.2	-1.0	-1.3	0.6
Alzheimer’s Disease (including proxy)	2.7	4.0	10.8	1.4	-1.4	-1.4	0.5	-3.2	-3.3	-0.4
Crohns Disease (2017)	1.1	2.4	8.1	-0.1	1.1	2.9	1.3	-0.0	1.0	2.1
Irritable Bowel Disease (IBD)	2.7	6.4	15.0	-0.2	2.3	3.9	2.7	1.0	1.4	3.8
Ulcerative Colitis (UC)	2.6	4.9	10.7	-0.6	2.1	3.0	2.6	1.2	1.4	3.3
Major Depression (MDD)	0.2	0.3	0.7	0.6	-0.8	-0.1	-0.5	0.3	-0.3	-0.5
Reaction Time	0.6	1.1	3.0	-0.8	1.4	1.7	-0.4	1.2	0.0	0.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.6	0.9	-0.2	-1.2	-1.9	-0.0	0.4	-0.1
Breast Cancer	0.3	0.7	1.9	-0.3	0.6	-1.0	0.5	-0.9	0.6	-1.4
Ovarian Cancer	1.0	1.3	1.9	-1.4	-1.3	-1.0	-1.4	-1.1	0.0	-1.0
Prostate Cancer	1.2	1.7	8.2	0.1	1.3	1.1	0.3	2.9	-0.1	0.9
Age at First Birth	0.6	0.9	2.7	0.3	-1.1	-1.6	-0.1	-0.2	0.1	-1.4
Bipolar Disorder (2011)	0.5	0.5	3.3	-0.4	1.8	-0.2	-0.2	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	0.9	1.0	-0.7	0.1	0.6	0.8	0.8	0.8
Coronary Artery Disease (CAD)	1.9	2.2	7.1	-0.3	0.8	2.7	0.8	-0.2	1.2	2.4
Crohns Disease (2012)	0.6	1.0	2.5	-0.2	1.1	0.8	1.5	-0.4	0.2	1.6
Mean Putamen Volume	0.8	0.9	4.2	0.0	-0.5	0.5	-2.1	0.6	-0.4	-1.0
Fasting Glucose	0.7	0.8	1.9	0.1	0.6	1.4	0.9	0.6	0.5	1.4
HbA1C	1.0	1.1	4.0	-0.2	0.5	2.0	1.2	0.6	-1.0	0.9
HDL Cholesterol	0.8	1.4	4.8	-2.2	0.9	0.8	-0.4	-0.9	-1.5	-0.1
LDL Cholesterol	0.4	0.6	1.8	-0.9	0.1	-1.1	-1.3	-0.3	-0.2	-0.7
Lupus	2.2	3.4	11.6	-1.2	3.4	1.1	2.4	1.4	1.1	-0.9
Neuroticism (2016)	0.5	0.8	2.5	1.6	-1.4	-0.2	-0.1	0.6	0.7	0.2
Primary Biliary Cirrhosis	2.0	2.8	8.3	1.0	-1.6	-1.6	-2.9	-0.4	-1.9	-1.1
Rheumatoid Arthritis	0.3	0.4	2.3	-0.0	0.1	-0.1	1.5	0.5	0.1	0.2
Schizophrenia (2014)	0.3	0.8	3.5	-0.2	0.1	-1.9	0.8	-0.3	-0.2	-1.0
Triglycerides	0.3	0.5	1.8	0.6	-1.3	-0.6	0.1	-0.1	0.1	0.9
Type 2 Diabetes (T2D) (2012)	1.8	2.1	7.4	1.4	-1.4	-0.9	-0.3	-1.4	-2.7	0.3
Ulcerative Colitis	2.4	3.5	9.5	-1.6	1.7	3.1	1.8	0.1	0.7	2.5
Blood Eosinophil Count	0.1	0.9	4.0	0.5	0.9	-0.1	0.3	0.7	1.0	-2.0
Blood Platelet Count	0.7	7.7	45.8	0.3	-0.4	-1.4	-0.7	-2.2	-6.8	-0.7
Blood Red Count	0.1	1.1	4.6	0.9	0.5	0.8	0.8	0.4	2.1	0.9
Blood White Count	0.7	5.2	13.8	1.3	-3.7	-2.2	-3.6	0.6	-1.4	-1.1
Heel T-Score	0.6	4.6	12.0	0.3	-1.1	-3.5	-0.1	-2.4	-2.8	-2.3
BMI	0.2	1.1	4.0	-1.0	0.1	2.0	-0.7	0.0	-0.8	-1.2
Height	0.1	1.6	5.2	1.1	0.2	-2.0	-0.0	0.1	2.3	0.8
Waist Hip Ratio (WHR)	0.9	3.8	12.1	0.7	-2.4	-1.1	-1.9	-0.5	-1.9	3.5
Systolic Blood Pressure	1.1	5.4	12.7	-3.2	1.9	2.0	-1.4	2.3	3.6	-0.0
Smoking Status	0.1	0.3	0.8	0.6	0.0	0.9	-0.3	0.1	-0.8	-0.2
Allergy or Eczema	0.4	1.1	2.6	-1.1	-0.2	-0.7	-1.6	-0.9	-0.9	-1.3
Cardiovascular Disease	0.8	2.6	7.0	-1.2	1.6	2.6	0.8	1.7	1.8	0.8
Hypothyroidism (self reported)	0.9	2.0	5.3	-1.2	1.8	1.1	0.5	1.6	2.3	-0.1
Respiratory disease	1.0	2.3	6.2	-0.8	2.3	0.6	0.5	1.1	2.5	1.4
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.6	0.1	-0.9	-0.4	-0.7	-2.3	-2.4	-1.7
Lung FEV1/FVC ratio	0.2	0.9	3.0	-1.7	0.8	0.2	-1.4	-0.4	-0.7	-0.4
Lung FVC	0.2	1.0	3.8	0.5	-0.4	0.8	1.9	-1.0	-1.0	0.6
Neuroticism	0.5	1.1	4.3	-0.3	-0.7	2.1	-0.9	-0.3	-0.6	1.2
Chronotype (morning person)	0.6	1.4	1.8	1.3	-1.2	-1.2	-1.3	-0.3	-1.2	1.3
Hair Pigment	0.0	0.5	1.4	0.6	0.3	-0.4	-1.0	0.1	-0.7	-1.2
Tanning	0.0	0.4	1.1	-0.5	1.1	-0.1	0.8	0.3	-0.2	-0.9
Hand grip strength (left)	0.5	1.2	3.2	1.8	0.3	-0.7	-0.1	0.8	1.6	1.2
Number of treatments/medications taken	0.6	1.2	2.7	-1.6	1.1	1.5	0.9	0.5	-0.9	0.5
Average weekly spirits intake	0.1	0.2	0.6	-0.5	0.8	0.2	-0.0	0.1	-0.5	-0.0
Sensitivity / hurt feelings	0.5	0.9	1.9	0.3	-1.4	1.1	-1.0	-0.8	-0.9	-0.7
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.4	-0.3	-1.2	-0.4	-1.8	-1.6	-0.9	-1.0
Hearing difficulty/problems: Yes	0.7	1.0	3.8	-1.9	1.1	0.8	0.3	0.6	-0.9	-0.6
Relative age of first facial hair	0.7	1.4	6.0	2.4	-0.1	-1.4	1.1	-0.3	-0.3	0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.1	-1.3	0.0	0.8	-0.0	0.4	1.4	-0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.3	-1.5	1.3	-0.3	0.6	-0.5	-0.1	0.1
Ever had hysterectomy (womb removed)	1.9	2.1	6.0	-2.4	1.9	0.7	-1.4	0.2	1.0	-1.4
Systolic blood pressure, automated reading	1.6	4.8	10.3	-3.2	2.4	2.6	-0.4	2.0	2.5	0.2
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	4.3	0.4	-0.9	-0.5	-1.0	-0.0	-2.1	0.3
Angina	0.6	0.9	3.2	-1.8	1.3	0.0	0.1	0.6	0.7	-0.1
Medication for hormone replacement therapy	0.5	0.6	3.0	-0.2	-0.1	-1.7	-0.6	-0.3	0.4	-0.5
Vitamin and mineral supplements	2.1	2.8	6.4	-1.5	2.5	2.0	0.3	2.3	1.3	0.2
Supplements: Zinc	2.1	2.3	7.1	0.7	-0.7	-2.7	-1.7	-1.5	-1.1	-1.1
Medication: Co-codamol	1.2	1.4	6.6	-2.6	0.7	1.0	0.4	-0.5	-0.7	-1.1
Medication: Metformin	1.3	1.8	4.5	-0.2	-1.4	-0.7	-0.7	-1.7	-2.1	-1.4
Diabetes (father)	0.6	0.7	1.5	0.6	-0.8	-1.2	-0.6	0.4	-0.9	-1.0
Diabetes (mother)	0.5	0.6	1.3	1.0	0.4	0.5	0.5	1.1	-0.8	0.8
Severe depression (siblings)	0.3	0.3	1.2	0.5	-0.3	-0.4	-0.2	-0.3	-1.1	-0.7
Pack years adult smoking proportion	0.7	1.1	2.1	-0.8	1.3	1.0	-0.0	1.4	1.4	-0.4
Impedance of leg (right)	0.2	1.0	4.6	0.3	1.2	-2.1	-0.0	0.1	-0.4	-0.7
Leg fat-free mass (left)	0.0	0.3	0.7	-0.1	-0.7	0.1	-0.8	-0.0	0.7	-0.3
Trunk fat percentage	0.3	1.4	4.4	-1.4	2.1	0.8	-0.8	1.1	0.6	-0.1
Hand grip strength (right)	0.8	2.1	6.8	2.6	0.5	-1.2	0.9	0.5	1.4	1.9
Townsend deprivation index at recruitment	1.7	2.4	4.6	-0.5	-1.9	-0.4	-1.9	-2.1	-2.1	0.3
Current tobacco smoking	0.4	0.6	2.0	0.2	0.7	0.7	-0.7	1.0	-1.4	0.4
Average weekly fortified wine intake	0.7	0.8	1.8	1.2	-0.2	1.0	1.4	-0.0	0.1	1.1
Maternal smoking around birth	1.1	1.5	4.6	-1.2	1.5	2.1	0.6	1.0	0.6	-0.9
Fed-up feelings	0.8	1.5	3.6	0.8	-1.8	1.9	-1.1	-0.0	-0.8	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.0	-0.3	-0.8	1.4	-0.2	-0.3	-0.7	-0.3
Relative age voice broke	0.2	0.4	1.3	0.6	-0.7	-0.5	0.2	-1.1	-0.5	-0.0
Taking other prescription medications	0.9	1.3	3.8	-1.4	1.6	1.9	0.8	0.3	0.1	0.7
Age when periods started (menarche)	1.3	3.2	12.3	-0.4	-0.5	-3.5	0.0	-2.2	-1.7	-1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.5	-0.5	-0.0	-1.2	-1.1	-0.8	0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.4	-1.5	1.0	0.4	1.1	0.3	0.3	-1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	0.2	-0.2	1.0	-0.1	1.0	0.1	0.0
Qualifications: CSEs or equivalent	1.5	2.0	8.7	3.0	-1.1	-1.4	-0.1	-0.9	-1.0	0.0
Serious illness, injury or assault to yourself	1.9	2.3	8.6	-1.5	0.6	2.9	1.7	1.3	-0.3	0.2
High blood pressure	1.5	4.3	9.4	-3.1	2.2	3.0	1.1	1.5	1.3	1.2
Hayfever, allergic rhinitis or eczema	0.7	1.6	2.7	-0.6	-1.2	-1.6	-1.4	-1.2	-1.1	-1.4
Multivitamins +/- minerals	1.3	1.6	3.8	1.7	-1.9	-0.9	0.0	-1.6	-1.1	0.1
Stomach or abdominal pain in last month	1.4	1.7	6.1	-0.2	0.7	2.5	1.5	0.9	-0.1	1.5
Supplements: Glucosamine	1.8	2.3	7.6	0.1	-0.7	-1.4	-0.5	-2.3	-2.8	-0.8
Diverticular disease/diverticulitis (self-reported)	4.0	4.8	10.9	0.9	2.5	2.3	0.4	3.3	2.3	2.1
Medication: Atenolol	0.8	1.0	3.4	-1.4	-0.2	-0.1	-1.8	0.4	0.3	1.2
Medication: Levothyroxine sodium	2.2	3.7	10.7	-1.7	3.3	1.2	1.7	1.4	2.5	0.4
Sitting height	0.2	1.8	9.3	0.4	0.8	-1.4	-0.1	0.3	3.0	0.4
Chronic bronchitis/emphysema (father)	1.2	1.4	5.2	0.2	1.0	0.9	-0.6	0.2	2.3	1.5
High blood pressure (mother)	1.0	1.4	5.2	-0.9	-0.4	1.4	1.0	0.6	-0.5	2.3
Body mass index (BMI)	0.4	1.8	8.3	-1.1	1.0	2.9	-0.1	1.2	0.4	-0.4
Impedance of leg (left)	0.3	1.2	7.2	0.3	0.9	-2.7	-0.5	-0.3	-0.3	-0.4
Leg predicted mass (left)	0.0	0.3	0.8	-0.1	-0.6	0.1	-0.9	-0.1	0.7	-0.3
Trunk fat mass	0.3	1.2	3.0	-1.4	1.7	0.8	-0.9	1.0	0.9	-0.3
Waist circumference	0.2	0.8	2.4	-1.2	0.1	1.5	-1.0	0.3	-0.7	0.4
Number of incorrect matches in round	0.7	1.2	3.6	-1.9	1.1	0.2	-1.3	0.8	1.0	0.3
Past tobacco smoking	0.6	1.1	2.2	1.5	-1.3	-0.4	-0.9	-0.8	0.3	1.5
Alcohol usually taken with meals	0.3	0.5	1.4	0.1	-0.7	-0.2	-1.2	-0.8	-0.4	-0.7
Nervous feelings	0.8	1.5	3.7	-1.1	0.4	1.2	0.2	1.3	1.5	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.1	-0.7	0.9	-1.1	-0.9	0.1	-0.0
Hearing difficulty/problems with background noise	1.1	1.7	4.2	-2.1	0.1	1.8	0.6	-0.5	-1.7	-1.1
Hair/balding pattern: Pattern 2	0.4	0.6	1.9	-0.6	1.4	-0.2	0.3	0.7	0.8	0.4
Had menopause	0.9	1.1	3.6	-1.7	1.9	0.2	-1.0	-0.3	-0.4	-0.4
Had other major operations	0.7	0.9	2.4	0.7	-0.8	-1.6	0.6	-1.0	-1.2	0.5
Forced vital capacity (FVC)	0.3	1.2	6.0	1.2	-0.4	-2.4	0.3	-1.0	0.2	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	-1.0	-0.1	-0.1	1.1	0.0	0.3	-0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.8	1.3	-0.3	1.0	-0.4	-1.1	-1.0	-0.5
Qualifications: None of the above	1.0	2.0	7.3	-2.2	1.0	2.7	0.5	0.7	-0.2	-0.3
Financial difficulties in last 2 years	0.8	1.1	2.2	1.1	-1.0	-0.7	-0.3	-0.7	-1.5	-1.5
Mouth/teeth dental problems	1.4	2.2	11.6	3.4	-1.2	-0.4	-0.8	0.4	1.1	0.6
Heart attack	3.2	4.1	8.8	-1.6	1.1	3.0	2.6	2.3	1.6	1.2
Allergy	0.3	0.7	2.4	1.6	-0.6	0.0	1.2	-0.7	-0.5	0.1
Pain all over the body in last month	0.9	1.0	1.9	-1.4	0.3	0.5	0.9	1.3	1.4	-0.2
Diabetes (self-reported)	1.1	1.6	4.5	-0.3	-1.4	-0.6	0.3	-1.7	-2.1	-1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.2	-0.2	-0.6	-1.0	-1.5	0.4	0.2	-0.2
Medication: Ramipril	0.5	0.7	2.8	-1.7	0.2	0.5	-1.0	0.9	0.2	-0.2
Medication: Simvastatin	0.7	1.0	2.4	-0.7	1.5	1.5	1.4	0.2	-0.6	-0.1
Fluid intelligence score	0.2	0.4	0.9	0.7	-0.2	-0.7	-1.0	-0.9	-0.7	-0.1
Illnesses of siblings	1.6	2.2	5.6	2.4	-1.3	-1.7	-1.4	0.1	-1.1	-1.4
Neuroticism score	0.7	1.4	3.6	0.0	-1.4	1.9	-1.8	-0.5	-0.5	0.6
Weight	0.1	0.6	1.2	-0.5	0.6	1.1	-0.8	0.9	1.1	-0.4
Impedance of arm (right)	0.3	1.5	8.7	0.1	0.4	-3.0	-0.8	-0.4	-0.8	0.4
Arm fat percentage (right)	0.4	1.5	3.6	-1.3	1.8	1.9	-0.4	1.2	0.4	-0.5
Trunk fat-free mass	0.1	0.5	1.2	0.4	-1.0	-0.1	-0.7	-0.3	1.1	-0.5
Hip circumference	0.2	0.8	2.3	-0.6	0.9	1.5	-0.4	0.9	0.7	-0.7
Time employed in main current job	0.7	0.8	2.5	-1.6	0.3	0.5	-1.2	0.4	1.1	-0.1
Alcohol intake versus 10 years previously	0.6	0.9	3.8	-1.2	-0.1	2.0	-1.0	0.1	0.4	0.1
Father’s age at death	0.7	1.0	2.2	-0.8	-1.0	-1.2	-0.6	-1.5	-0.4	-1.0
Worrier / anxious feelings	0.9	1.8	4.6	-2.1	-0.5	1.2	-1.9	-0.0	-0.3	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.0	0.5	-0.3	-0.7	0.5	-0.2	0.8	-1.0
Falls in the last year	1.8	2.4	6.0	1.9	-1.5	-0.2	-0.3	-0.8	-2.4	-2.1
Hair/balding pattern: Pattern 3	1.3	1.9	6.2	2.5	-2.0	-0.2	-0.4	-1.5	-0.3	1.0
Number of live births	1.1	1.5	6.7	0.0	0.8	1.1	0.9	2.6	1.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	5.6	0.5	-0.3	-2.4	-0.2	-0.6	0.1	-0.0
Pulse rate	0.5	0.9	1.8	1.1	-0.5	-1.3	0.2	-1.1	-0.3	-1.3
Happiness	1.2	1.4	4.9	0.4	-1.0	0.4	-1.2	-2.2	-1.5	0.4
Noisy workplace	0.7	0.9	2.2	-1.5	0.6	-0.3	-1.2	0.8	-0.5	-0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.1	0.3	-0.8	-1.4	-0.3	0.0	-0.5	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.8	1.7	-1.3	-0.5	0.4	0.3	-0.2	-1.0
Mouth/teeth dental problems: Dentures	1.0	1.7	6.3	-2.5	1.8	0.8	0.7	-0.9	-0.1	0.2
Asthma	1.5	2.9	7.2	-1.1	2.7	1.5	0.1	1.4	2.4	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.7	-0.9	-0.5	-1.7	-0.7	0.2	0.9	-1.2
Medication: Cholesterol lowering	0.7	1.0	2.5	-1.2	0.8	1.6	1.0	0.9	-0.5	0.7
Depression (self-reported)	0.5	0.7	2.9	0.5	0.9	-0.3	-0.0	0.7	1.7	-0.4
Medication: Lansoprazole	0.4	0.5	1.8	-0.4	0.4	0.4	1.4	0.3	-0.6	-0.7
Prospective memory result	0.6	0.7	2.0	-0.6	0.7	0.8	-0.0	-0.1	1.4	1.2
Lung cancer (father)	0.6	0.8	1.9	-1.4	0.3	0.8	-0.7	-0.7	-0.3	-1.3
Illnesses of mother	0.5	0.7	3.0	0.8	0.9	-0.1	-0.5	-0.0	0.0	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.1	0.2	-0.5	-1.8	-0.5	-1.5	-0.3	-0.3
Pulse wave Arterial Stiffness index	0.7	0.9	3.0	1.7	0.4	-0.2	0.3	0.7	0.8	1.3
Impedance of arm (left)	0.4	2.1	12.7	0.5	0.3	-3.6	-0.8	-0.3	-0.6	0.5
Arm fat mass (right)	0.3	1.1	3.0	-0.8	1.2	1.7	-0.6	1.1	0.8	-0.3
Trunk predicted mass	0.1	0.5	1.2	0.4	-1.1	-0.0	-0.8	-0.4	1.1	-0.5
Standing height	0.3	3.1	14.0	1.4	-0.7	-3.7	-1.5	-0.6	1.6	0.3
Length of working week for main job	1.2	1.3	3.7	1.4	-1.9	0.6	0.1	-0.3	-1.6	-0.7
Exposure to tobacco smoke at home	1.3	1.5	4.4	0.7	-0.2	1.8	1.2	-0.9	-2.1	-0.2
Breastfed as a baby	0.1	0.1	0.3	0.1	0.1	0.3	0.5	0.6	-0.1	0.3
Tense / ‘highly strung’	0.9	1.5	7.6	0.2	-0.3	2.8	1.0	-0.3	-0.1	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.1	0.6	-1.0	0.4	-0.6	0.3	-0.0	0.8
Hair/balding pattern: Pattern 4	1.1	2.6	10.1	-3.2	-0.1	-0.7	-0.7	-1.2	-1.0	-2.3
Birth weight of first child	0.7	1.3	3.7	0.4	-0.2	-1.9	1.0	-1.6	-1.2	-0.5
Peak expiratory flow (PEF)	0.6	1.4	4.0	-0.0	0.5	-2.0	-0.2	-0.6	-1.7	-1.5
Pulse wave reflection index	0.7	0.8	3.2	1.4	0.3	0.3	0.1	0.6	0.5	1.8
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.4	1.1	-1.1	-0.1	-0.3	-0.7	-1.0	-1.6
Loud music exposure frequency	0.8	0.9	3.6	1.0	-0.5	-0.5	-0.3	0.8	1.9	0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	1.1	-0.8	-1.0	0.7	-0.8	0.9	-0.0
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.8	-1.6	-0.2	0.8	-0.0	-0.5	-0.7	-1.7
Blood clot in the leg (DVT)	1.0	1.3	4.0	0.8	-0.3	0.6	-0.3	2.0	1.9	0.7
Medication: Paracetamol	0.4	0.7	2.2	-1.5	-1.0	0.2	-0.7	0.1	-0.2	-1.0
Headache pain in last month	0.5	0.8	2.5	0.0	-1.2	-0.2	-0.9	0.6	-0.8	-1.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	4.3	2.1	-0.8	-1.1	-0.4	-0.9	-0.2	-0.5
Glaucoma (self-reported)	1.8	2.1	5.2	0.4	-2.3	-2.0	-1.6	-1.4	-0.6	-0.8
Gout (self-reported)	0.8	1.2	3.1	-0.5	0.2	1.8	-1.2	-0.8	-1.0	-1.3
Hypothyroidism/myxoedema (self-reported)	2.5	4.8	11.3	-1.5	3.1	1.8	1.3	2.2	3.4	0.8
Medication: Amlodipine	0.7	1.0	3.5	-1.9	0.4	0.7	-0.4	-0.1	-1.4	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.5	0.5	0.7	0.3	0.1	0.2	0.0	-0.3
Birth weight	1.7	3.7	7.3	1.6	-2.1	-2.7	-0.6	-2.4	-1.9	-1.3
Chronic bronchitis/emphysema (mother)	1.3	1.5	4.8	2.2	-1.8	-0.8	-0.1	0.8	0.7	0.8
High blood pressure (siblings)	1.4	2.0	4.3	-1.2	0.6	1.8	2.1	-0.5	-0.6	2.0
Forced vital capacity (FVC), Best measure	0.3	1.1	3.9	0.9	-0.6	-2.0	-0.2	-1.5	-0.0	-0.1
Body fat percentage	0.5	2.1	5.7	-1.8	2.4	1.6	-0.6	1.3	0.6	-0.6
Leg fat percentage (right)	1.0	3.7	8.9	-2.0	2.7	3.0	0.3	1.8	0.8	-1.3
Arm fat-free mass (right)	0.1	0.4	1.1	0.1	-0.7	0.5	-1.1	-0.2	0.9	-0.6
Exposure to tobacco smoke outside home	0.2	0.3	0.9	1.0	-0.2	-0.1	0.4	0.5	0.0	0.7
Comparative body size at age 10	0.3	0.9	2.7	-1.0	-0.1	0.7	0.1	-1.0	-0.9	-1.6
Number of full brothers	1.0	1.3	3.2	-0.8	-0.7	1.8	-0.4	-1.2	-1.1	-1.3
Worry too long after embarrassment	0.3	0.6	3.3	0.1	-0.1	1.8	-0.5	-0.1	0.3	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.8	-0.2	-0.2	-0.8	-0.1	0.1	0.3
Wheeze or whistling in the chest in last year	0.7	1.2	3.2	-0.9	1.8	-0.1	-1.7	-1.2	0.4	0.1
Number of children fathered	1.8	2.1	7.3	-2.7	0.5	2.2	0.9	0.6	0.9	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.4	-0.2	1.4	1.8	1.1	0.7	1.2	1.9
Age at first live birth	0.7	1.3	2.3	1.5	-0.9	-1.2	-0.4	-1.5	-1.1	-1.0
Pulse wave peak to peak time	0.6	0.7	2.1	-1.4	-0.3	-0.1	-0.2	-0.7	-0.8	-1.2
Health satisfaction	0.3	0.4	1.8	0.2	0.9	-0.1	1.3	-0.0	-0.5	0.4
Shortness of breath walking on level ground	0.5	0.6	1.3	0.9	0.2	1.1	0.6	0.7	0.3	1.1
Qualifications: College or University degree	0.9	2.9	13.1	1.8	-1.1	-3.6	-0.5	-1.4	-0.7	-0.2
Eye problems/disorders: None of the above	0.3	0.4	1.6	0.6	1.3	-0.4	0.1	0.1	-0.7	-0.1
Mouth/teeth dental problems: Loose teeth	1.0	1.1	5.7	-0.6	2.4	-0.6	0.8	0.7	0.6	-0.2
Emphysema/chronic bronchitis	0.8	1.0	2.5	-1.0	-0.3	-1.1	-1.6	-0.1	0.3	-1.3
Medication for pain relief, constipation, heartburn	0.3	0.4	1.0	1.0	0.4	-0.8	0.3	-0.2	0.5	0.9
Neck or shoulder pain in last month	2.0	2.9	13.6	-0.1	-1.1	-0.3	-1.3	-1.4	-1.2	-3.7
Medication: Blood pressure	0.6	1.0	3.1	-1.8	0.1	0.7	0.4	1.2	0.6	1.1
Angina (self-reported)	0.7	1.0	3.4	-1.9	1.3	0.0	-0.0	0.9	0.8	0.0
Migraine (self-reported)	0.8	1.0	3.6	-0.4	0.3	1.9	0.7	1.3	0.1	-1.1
Medication: Ibuprofen	0.7	0.8	3.8	-0.3	-0.5	-1.9	-0.5	0.3	0.1	-1.1
Medication: Allopurinol	0.8	1.0	3.7	0.1	-0.2	1.0	-0.6	-0.9	-1.9	-1.2
Medication: Omeprazole	0.7	0.9	2.2	1.5	-0.9	-0.6	-0.7	-0.9	-0.9	-0.7
Medication: Seretide 50 evohaler	1.6	1.8	6.9	0.5	1.5	2.6	-0.8	0.8	1.1	0.8
Mean time to correctly identify matches	1.0	1.9	4.9	-1.7	2.2	1.9	-0.8	1.0	-0.1	-0.0
Heart disease (mother)	4.1	4.9	11.6	-2.3	2.2	2.8	1.1	0.8	3.4	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.0	-2.0	1.0	-0.3	1.8	-0.3	-0.6	-0.9
Whole body fat mass	0.3	1.4	2.5	-1.4	1.6	1.5	-0.8	1.1	0.9	-0.6
Leg fat mass (right)	0.5	2.0	4.2	-1.6	1.8	2.0	-0.2	1.2	0.9	-1.2
Arm predicted mass (right)	0.1	0.6	1.6	-0.1	-0.6	0.5	-1.3	-0.3	0.9	-0.9
Pulse rate, automated reading	0.3	1.1	2.9	-0.7	1.7	0.9	1.0	1.1	0.9	-0.8
Alcohol intake frequency.	0.9	2.1	9.2	0.8	-3.0	1.8	-1.1	-0.5	-0.3	-0.4
Comparative height size at age 10	0.4	2.1	7.9	0.0	-0.2	-2.3	-2.8	-0.8	0.8	-0.7
Number of full sisters	0.3	0.3	0.8	0.2	0.8	0.6	0.9	0.5	0.2	-0.4
Suffer from ‘nerves’	0.4	0.6	1.2	0.6	-1.0	0.7	-0.9	-0.6	-1.1	-0.4
Overall health rating	0.8	1.7	4.9	-2.1	1.1	2.2	0.9	0.7	0.5	-0.0
Chest pain or discomfort	1.5	2.1	5.8	-1.4	1.8	2.4	0.0	1.6	0.6	1.2
Had major operations	1.0	1.1	3.9	-0.6	0.3	0.8	1.6	2.0	0.2	-0.4
Age at last live birth	0.7	1.1	3.8	1.9	-0.3	1.0	1.0	0.7	-0.8	0.6
Family relationship satisfaction	1.7	2.1	5.4	1.8	-1.2	-1.1	-0.0	-1.6	-0.9	2.3
Leg pain on walking	0.8	1.0	3.3	-0.9	1.8	-0.4	-0.1	-1.1	0.9	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.6	-1.3	2.1	1.7	0.9	0.9	0.9	0.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.3	-0.1	-0.4	0.8	1.2	-1.3	0.1	-1.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.6	0.7	0.5	-0.6	-0.8	-0.7	0.7	0.6
Medication: Aspirin	0.9	1.2	4.7	-2.2	1.0	0.7	0.7	0.5	-1.1	-0.4
Supplements: Vitamin C	0.7	0.8	4.1	0.5	-0.4	-2.0	0.5	-0.6	0.0	0.5
Knee pain experienced in last month	1.2	1.9	10.2	-0.6	1.0	3.2	-0.3	0.2	-1.3	-0.3
Hypertension (Self-reported)	1.6	4.6	10.6	-3.3	2.0	3.1	1.1	1.8	1.2	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	3.1	1.8	0.2	0.4	0.4	0.8	-1.1	0.9
Illnesses of father: Heart disease	0.6	0.8	1.8	0.1	0.7	0.7	1.3	-1.0	-1.0	0.8
Illnesses of siblings: Diabetes	2.4	3.0	5.7	-2.1	1.6	2.0	1.7	0.9	2.4	0.1
Smoking status: Previous	0.8	1.1	2.3	-1.5	1.2	0.5	1.1	0.7	0.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	11.2	1.6	-1.3	-3.4	-0.6	-1.7	-0.8	-1.2
Whole body fat-free mass	0.1	0.5	1.0	0.2	-1.0	-0.1	-1.0	-0.4	0.9	-0.5
Leg fat-free mass (right)	0.1	0.6	1.6	0.3	-1.1	-0.4	-1.3	-0.5	0.7	-0.3
Arm fat percentage (left)	0.3	1.2	3.0	-1.2	1.6	1.7	-0.6	1.1	0.4	-0.5
Average weekly red wine intake	1.4	2.0	6.6	-1.8	1.7	-0.2	0.0	1.1	2.6	-0.5
Handedness (chirality/laterality): Left-handed	2.2	2.7	6.1	-2.5	1.8	1.9	0.4	0.5	1.3	1.8
Mood swings	0.8	1.5	2.6	-1.2	-1.2	1.4	-1.6	-1.5	0.8	0.3
Loneliness, isolation	1.2	1.7	3.8	-0.1	-1.6	-1.0	-1.9	-1.3	-1.7	-0.3
Long-standing illness, disability or infirmity	0.7	1.1	3.0	-1.6	0.9	0.9	-0.1	1.7	0.5	-0.6
Ever had bowel cancer screening	0.9	1.0	3.9	-2.0	0.1	1.2	0.7	-1.1	-0.4	-0.2
Diabetes diagnosed by doctor	0.8	1.2	3.5	-0.6	-0.7	-0.4	0.8	-1.5	-1.9	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.7	1.3	-1.0	0.4	-1.1	0.2	0.8	0.4
Friendships satisfaction	2.7	3.3	5.7	1.4	-2.1	-1.9	-1.6	-2.4	-2.2	0.3
Qualifications: nursing, teaching	1.0	1.5	4.0	1.5	-1.2	-2.0	-0.5	-0.4	-1.3	0.8
Commuting to job workplace: Walk	0.8	0.8	3.7	0.1	1.0	0.5	-0.3	1.9	0.4	0.7
Eye problems/disorders: Cataract	1.0	1.1	3.8	-0.7	-0.3	0.5	-1.0	-1.5	-0.1	-1.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	4.8	-2.2	-0.2	1.0	0.6	0.1	-1.6	-0.0
Medication for cholesterol	1.5	2.3	6.6	0.5	-2.6	-2.0	-1.6	-1.2	-1.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.3	-0.2	1.4	1.5	0.6	1.5	-0.2	0.2
Back pain experienced in last month	1.2	1.7	6.2	-1.7	0.3	-0.4	-0.4	-1.0	-1.3	-2.5
Mineral and other dietary supplements	3.8	5.1	10.3	0.9	1.8	3.2	1.0	3.0	2.6	2.0
Breast cancer (self-reported)	0.8	1.0	2.8	-0.6	1.5	0.4	1.0	-0.2	0.3	-1.7
Asthma (self-reported)	1.2	2.4	5.3	-0.7	2.3	1.3	0.2	1.4	2.2	1.6
Osteoporosis (self-reported)	0.7	0.9	2.0	1.1	0.7	0.7	0.9	0.8	0.8	1.4
Osteoarthritis (self-reported)	1.1	1.4	3.5	-0.5	1.2	1.9	0.4	-0.9	-1.4	-1.3
Medication: Aspirin	0.8	1.1	4.6	-2.2	1.0	0.8	0.3	0.9	-0.5	-0.4
Medication: Gliclazide	0.6	0.6	3.6	-0.4	-0.8	0.0	0.2	-0.1	-1.9	0.2
Illnesses of father: None of the above (group 1)	0.3	0.4	1.5	-0.2	-1.2	-0.5	0.3	-0.1	-0.8	-0.3
Smoking status: Current	0.5	0.7	2.9	0.3	0.4	0.7	-0.8	0.9	-1.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.6	-0.8	1.2	0.4	1.9	0.7	1.8	1.2
Whole body water mass	0.1	0.4	1.0	0.2	-1.0	0.0	-1.0	-0.3	0.8	-0.3
Leg predicted mass (right)	0.1	0.5	1.4	0.2	-1.0	-0.4	-1.2	-0.5	0.7	-0.3
Arm fat mass (left)	0.2	0.9	2.9	-0.7	1.2	1.7	-0.7	0.9	0.6	-0.2
Number of self-reported non-cancer illnesses	2.7	4.7	8.9	-2.0	3.0	2.7	1.6	2.4	1.3	1.6
Average weekly champagne plus white wine intake	2.2	3.0	6.3	-0.6	-1.6	-1.1	-1.8	-2.4	-2.5	-1.2
Miserableness	0.8	1.3	5.0	0.6	-2.2	0.2	-1.5	-0.6	-1.1	0.1
Guilty feelings	0.8	1.2	3.5	-0.6	-1.2	0.5	-1.9	-1.1	1.3	0.0
Wears glasses or contact lenses	3.5	4.1	8.0	-2.2	2.5	1.6	-0.6	2.8	2.0	1.6
Ever taken oral contraceptive pill	0.4	0.4	1.3	-0.1	-0.5	-0.9	-0.0	-0.5	1.1	0.4
Hearing aid user	0.4	0.5	2.3	-0.0	0.1	-0.3	-0.8	-0.3	-0.4	-1.5
Mother’s age at death	0.7	0.9	4.6	-0.2	0.5	0.5	2.1	-0.9	-0.4	-0.4
Financial situation satisfaction	0.5	0.6	1.5	0.2	0.5	0.3	0.3	-1.2	-1.0	-1.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.1	-0.9	1.0	0.7	0.6	0.6	0.6	-0.3
Commuting to job workplace: Public transport	0.6	0.7	2.8	0.1	0.5	-0.5	-0.1	1.7	0.8	1.1
Eye problems/disorders: Glaucoma	1.5	1.7	6.7	0.4	-2.6	-1.2	-1.5	-0.7	-0.7	-0.7
Medication: Blood pressure	1.2	2.2	5.7	-2.1	2.4	2.1	0.3	0.5	0.0	0.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	5.3	-1.5	0.9	2.3	-0.2	-0.4	0.5	-1.2
Supplements: Fish oil (including cod liver oil)	2.8	3.7	7.3	-1.2	-1.8	-2.3	-0.7	-2.7	-1.6	-2.4
High cholesterol (Self-reported)	0.4	0.8	1.8	-0.7	1.0	1.1	1.3	0.2	-0.8	-0.3
Medication: Bendroflumethiazide	3.2	4.8	14.2	-1.8	3.3	3.8	0.9	2.0	0.6	0.4
Medication: Paracetamol	0.5	0.8	1.6	-1.3	-1.1	-0.1	-1.3	0.4	-0.2	-0.9
Medication: Lisinopril	1.2	1.5	5.3	0.1	-0.2	0.1	-1.6	-1.0	-1.4	-2.3
Medication: Atorvastatin	0.6	0.8	1.6	-1.3	0.7	0.8	1.0	0.4	-0.3	1.2
Illnesses of father: High blood pressure	0.2	0.2	0.9	-0.2	0.9	0.5	-0.3	0.3	-0.2	0.1
Alcohol drinker status: Never	1.7	2.0	7.7	0.1	-2.8	-1.2	-0.8	-1.7	-0.9	-0.9
Ever smoked	0.8	1.5	3.4	-1.4	1.9	0.8	0.5	1.2	0.1	-1.6
Basal metabolic rate	0.1	0.4	1.1	0.2	-0.6	0.3	-1.0	-0.0	1.0	-0.4
Leg fat percentage (left)	0.8	3.0	7.1	-1.8	2.5	2.7	-0.1	1.7	0.8	-1.0
Arm fat-free mass (left)	0.1	0.4	1.1	-0.0	-0.2	1.0	-0.7	0.1	0.8	-0.5
Number of operations (self-reported)	0.3	0.4	0.9	0.8	-0.3	-0.9	0.4	0.8	-0.7	0.0
Average weekly beer plus cider intake	0.8	1.1	4.3	-0.2	1.1	0.7	0.3	2.1	-0.1	1.2
Irritability	0.5	0.8	2.4	-1.1	-0.5	0.7	-1.5	-0.6	-1.1	-0.3
Risk taking	0.8	1.1	3.6	1.2	-1.0	0.1	-0.2	-1.4	-1.9	0.0
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.5	-1.9	0.9	-0.1	-0.9	0.1	-0.0	-1.1
Fractured/broken bones in last 5 years	0.4	0.5	1.8	0.8	0.5	1.3	0.2	1.0	-0.2	0.1
Age started oral contraceptive pill	0.6	0.7	1.4	-0.2	-0.5	0.7	-0.6	-1.2	-1.0	-1.1
Diastolic blood pressure, automated reading	1.9	5.9	11.4	-2.7	3.4	3.3	-1.0	1.9	2.6	0.2
Ever depressed for a whole week	0.9	1.1	2.1	0.8	-1.0	1.4	1.2	-0.3	-1.5	0.7
Unable to work because of sickness or disability	0.8	1.0	2.4	-0.8	-0.1	0.2	-1.5	1.1	-1.4	-0.8
Commuting to job workplace: Cycle	1.3	1.6	4.9	1.6	-1.0	-2.2	-0.4	0.6	-0.7	1.4
Myopia	0.9	1.3	5.2	-0.6	-0.1	-2.3	-0.2	-0.7	-1.5	1.0
Vascular/heart problems diagnosed by doctor	2.0	5.4	13.4	3.7	-2.6	-3.2	-1.1	-1.7	-1.3	-1.2
Cholesterol lowering medication	1.8	2.6	6.6	-0.5	2.1	2.6	2.5	0.5	-0.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.8	1.7	-0.9	-0.4	-0.9	-1.3	-1.3	-0.4
Pain experienced in last month	0.8	1.4	5.2	1.2	0.4	-2.3	-0.2	-0.2	0.2	1.7
Supplements: Calcium	1.6	1.7	6.8	0.4	-1.1	-1.0	-0.1	-2.6	-1.6	-0.0
Basal cell carcinoma (self-reported)	1.0	1.2	6.7	-0.1	2.6	0.9	0.6	0.5	-0.4	-0.2
Heart attack/myocardial infarction (self-reported)	3.0	3.9	8.9	-1.5	0.9	3.0	2.6	2.3	1.3	1.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	4.1	0.6	-0.2	0.6	-0.3	2.0	1.6	0.5
Heart disease (siblings)	0.6	0.7	3.5	-1.9	-1.0	0.5	-0.1	-0.2	-0.2	-0.1
Alcohol drinker status: Previous	0.5	0.6	2.5	0.7	-0.3	1.6	0.1	1.0	0.1	0.1
Pack years of smoking	1.0	1.5	3.0	-1.2	1.7	1.3	-0.2	1.4	1.4	-0.6
Impedance of whole body	0.3	1.6	9.6	0.3	1.0	-3.1	-0.7	-0.0	-0.3	0.2
Leg fat mass (left)	0.5	1.8	3.6	-1.7	1.7	1.9	-0.4	1.2	0.9	-1.1
Arm predicted mass (left)	0.1	0.4	1.1	-0.0	-0.5	0.6	-1.0	-0.1	0.7	-0.8