Hub : Genes

PLCG2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Pancreas 0.4860 0.0910 1.6e-04 0.242 NA 0.228 NA 0.229 1.3e-10 NA 5.3e-10 NA 4.5e-10
2 GTEx Skin Sun Exposed Lower leg 0.2670 0.0640 1.1e-04 0.006 NA 0.036 NA 0.030 1.0e-01 NA 5.9e-04 NA 1.4e-03
3 METSIM Adipose 0.1395 0.0385 1.6e-04 0.038 0.040 0.050 0.043 0.023 1.8e-06 1.2e-06 4.6e-08 4.9e-07 1.6e-04
4 YFS Blood 0.0706 0.0171 2.3e-07 0.027 0.028 0.060 0.055 0.067 2.5e-09 1.1e-09 8.0e-19 2.1e-17 4.5e-21
5 TCGA Brain Lower Grade Glioma 0.1098 0.0321 5.6e-05 -0.002 0.037 0.009 NA -0.001 7.3e-01 4.4e-05 3.1e-02 NA 5.4e-01
6 TCGA Lung Squamous Cell Carcinoma 0.1014 0.0323 1.9e-04 -0.001 0.031 0.001 NA 0.000 4.8e-01 1.7e-04 2.2e-01 NA 3.7e-01
7 TCGA Pancreatic Adenocarcinoma 0.2400 0.0830 3.0e-03 0.000 0.053 0.016 NA -0.002 3.2e-01 3.0e-03 6.9e-02 NA 4.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.4 0.6 3.3 -0.4 0.6 -0.4 0.6 -1.8 -0.2 0.4
Bipolar Disorder or Schizophrenia 0.3 0.8 1.9 -0.6 0.6 -1.2 1.2 -1.4 -0.1 -0.7
Depressed Affect (Nagel 2018) 0.4 0.9 2.4 -1.0 -1.5 0.7 -1.6 -0.6 0.0 -0.1
Depression (Nagel 2018) 0.1 0.1 0.6 -0.8 -0.1 0.6 -0.2 0.1 0.1 0.2
Intelligence (Savage-Jansen 2018) 0.7 2.0 4.4 1.7 -1.9 -1.5 -2.1 -0.6 -0.5 0.3
Neuroticism (Nagel 2018) 0.3 0.8 2.6 -1.0 -0.6 1.6 -0.9 0.2 0.2 0.7
Schizophrenia (2018) 0.3 0.7 1.7 -0.4 0.4 -1.3 1.1 -0.2 0.0 -1.3
Schizophrenia vs Biploar Disorder 0.3 0.4 1.2 0.0 -0.4 -1.1 0.4 0.8 -0.3 -0.7
Worry (Nagel 2018) 0.4 0.9 2.2 -1.3 0.4 1.5 0.2 0.7 0.2 1.4
Alzheimer’s Disease (in mother) 1.3 1.5 4.5 0.8 -0.8 0.3 1.4 -1.7 -2.1 -0.1
Alzheimer’s Disease (in father) 0.7 0.7 1.7 -0.7 0.0 -1.2 -0.2 -1.0 -1.3 0.6
Alzheimer’s Disease (including proxy) 2.7 4.0 10.8 1.4 -1.4 -1.4 0.5 -3.2 -3.3 -0.4
Crohns Disease (2017) 1.1 2.4 8.1 -0.1 1.1 2.9 1.3 -0.0 1.0 2.1
Irritable Bowel Disease (IBD) 2.7 6.4 15.0 -0.2 2.3 3.9 2.7 1.0 1.4 3.8
Ulcerative Colitis (UC) 2.6 4.9 10.7 -0.6 2.1 3.0 2.6 1.2 1.4 3.3
Major Depression (MDD) 0.2 0.3 0.7 0.6 -0.8 -0.1 -0.5 0.3 -0.3 -0.5
Reaction Time 0.6 1.1 3.0 -0.8 1.4 1.7 -0.4 1.2 0.0 0.4
Verbal and Numeric Reasoning (VNR) 0.4 0.9 3.6 0.9 -0.2 -1.2 -1.9 -0.0 0.4 -0.1
Breast Cancer 0.3 0.7 1.9 -0.3 0.6 -1.0 0.5 -0.9 0.6 -1.4
Ovarian Cancer 1.0 1.3 1.9 -1.4 -1.3 -1.0 -1.4 -1.1 0.0 -1.0
Prostate Cancer 1.2 1.7 8.2 0.1 1.3 1.1 0.3 2.9 -0.1 0.9
Age at First Birth 0.6 0.9 2.7 0.3 -1.1 -1.6 -0.1 -0.2 0.1 -1.4
Bipolar Disorder (2011) 0.5 0.5 3.3 -0.4 1.8 -0.2 -0.2 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 0.9 1.0 -0.7 0.1 0.6 0.8 0.8 0.8
Coronary Artery Disease (CAD) 1.9 2.2 7.1 -0.3 0.8 2.7 0.8 -0.2 1.2 2.4
Crohns Disease (2012) 0.6 1.0 2.5 -0.2 1.1 0.8 1.5 -0.4 0.2 1.6
Mean Putamen Volume 0.8 0.9 4.2 0.0 -0.5 0.5 -2.1 0.6 -0.4 -1.0
Fasting Glucose 0.7 0.8 1.9 0.1 0.6 1.4 0.9 0.6 0.5 1.4
HbA1C 1.0 1.1 4.0 -0.2 0.5 2.0 1.2 0.6 -1.0 0.9
HDL Cholesterol 0.8 1.4 4.8 -2.2 0.9 0.8 -0.4 -0.9 -1.5 -0.1
LDL Cholesterol 0.4 0.6 1.8 -0.9 0.1 -1.1 -1.3 -0.3 -0.2 -0.7
Lupus 2.2 3.4 11.6 -1.2 3.4 1.1 2.4 1.4 1.1 -0.9
Neuroticism (2016) 0.5 0.8 2.5 1.6 -1.4 -0.2 -0.1 0.6 0.7 0.2
Primary Biliary Cirrhosis 2.0 2.8 8.3 1.0 -1.6 -1.6 -2.9 -0.4 -1.9 -1.1
Rheumatoid Arthritis 0.3 0.4 2.3 -0.0 0.1 -0.1 1.5 0.5 0.1 0.2
Schizophrenia (2014) 0.3 0.8 3.5 -0.2 0.1 -1.9 0.8 -0.3 -0.2 -1.0
Triglycerides 0.3 0.5 1.8 0.6 -1.3 -0.6 0.1 -0.1 0.1 0.9
Type 2 Diabetes (T2D) (2012) 1.8 2.1 7.4 1.4 -1.4 -0.9 -0.3 -1.4 -2.7 0.3
Ulcerative Colitis 2.4 3.5 9.5 -1.6 1.7 3.1 1.8 0.1 0.7 2.5
Blood Eosinophil Count 0.1 0.9 4.0 0.5 0.9 -0.1 0.3 0.7 1.0 -2.0
Blood Platelet Count 0.7 7.7 45.8 0.3 -0.4 -1.4 -0.7 -2.2 -6.8 -0.7
Blood Red Count 0.1 1.1 4.6 0.9 0.5 0.8 0.8 0.4 2.1 0.9
Blood White Count 0.7 5.2 13.8 1.3 -3.7 -2.2 -3.6 0.6 -1.4 -1.1
Heel T-Score 0.6 4.6 12.0 0.3 -1.1 -3.5 -0.1 -2.4 -2.8 -2.3
BMI 0.2 1.1 4.0 -1.0 0.1 2.0 -0.7 0.0 -0.8 -1.2
Height 0.1 1.6 5.2 1.1 0.2 -2.0 -0.0 0.1 2.3 0.8
Waist Hip Ratio (WHR) 0.9 3.8 12.1 0.7 -2.4 -1.1 -1.9 -0.5 -1.9 3.5
Systolic Blood Pressure 1.1 5.4 12.7 -3.2 1.9 2.0 -1.4 2.3 3.6 -0.0
Smoking Status 0.1 0.3 0.8 0.6 0.0 0.9 -0.3 0.1 -0.8 -0.2
Allergy or Eczema 0.4 1.1 2.6 -1.1 -0.2 -0.7 -1.6 -0.9 -0.9 -1.3
Cardiovascular Disease 0.8 2.6 7.0 -1.2 1.6 2.6 0.8 1.7 1.8 0.8
Hypothyroidism (self reported) 0.9 2.0 5.3 -1.2 1.8 1.1 0.5 1.6 2.3 -0.1
Respiratory disease 1.0 2.3 6.2 -0.8 2.3 0.6 0.5 1.1 2.5 1.4
Type 2 Diabetes (T2D) (2018) 1.2 2.2 5.6 0.1 -0.9 -0.4 -0.7 -2.3 -2.4 -1.7
Lung FEV1/FVC ratio 0.2 0.9 3.0 -1.7 0.8 0.2 -1.4 -0.4 -0.7 -0.4
Lung FVC 0.2 1.0 3.8 0.5 -0.4 0.8 1.9 -1.0 -1.0 0.6
Neuroticism 0.5 1.1 4.3 -0.3 -0.7 2.1 -0.9 -0.3 -0.6 1.2
Chronotype (morning person) 0.6 1.4 1.8 1.3 -1.2 -1.2 -1.3 -0.3 -1.2 1.3
Hair Pigment 0.0 0.5 1.4 0.6 0.3 -0.4 -1.0 0.1 -0.7 -1.2
Tanning 0.0 0.4 1.1 -0.5 1.1 -0.1 0.8 0.3 -0.2 -0.9
Hand grip strength (left) 0.5 1.2 3.2 1.8 0.3 -0.7 -0.1 0.8 1.6 1.2
Number of treatments/medications taken 0.6 1.2 2.7 -1.6 1.1 1.5 0.9 0.5 -0.9 0.5
Average weekly spirits intake 0.1 0.2 0.6 -0.5 0.8 0.2 -0.0 0.1 -0.5 -0.0
Sensitivity / hurt feelings 0.5 0.9 1.9 0.3 -1.4 1.1 -1.0 -0.8 -0.9 -0.7
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.4 -0.3 -1.2 -0.4 -1.8 -1.6 -0.9 -1.0
Hearing difficulty/problems: Yes 0.7 1.0 3.8 -1.9 1.1 0.8 0.3 0.6 -0.9 -0.6
Relative age of first facial hair 0.7 1.4 6.0 2.4 -0.1 -1.4 1.1 -0.3 -0.3 0.4
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 2.1 -1.3 0.0 0.8 -0.0 0.4 1.4 -0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.7 2.3 -1.5 1.3 -0.3 0.6 -0.5 -0.1 0.1
Ever had hysterectomy (womb removed) 1.9 2.1 6.0 -2.4 1.9 0.7 -1.4 0.2 1.0 -1.4
Systolic blood pressure, automated reading 1.6 4.8 10.3 -3.2 2.4 2.6 -0.4 2.0 2.5 0.2
Eye problems/disorders: Diabetes related eye disease 0.9 0.9 4.3 0.4 -0.9 -0.5 -1.0 -0.0 -2.1 0.3
Angina 0.6 0.9 3.2 -1.8 1.3 0.0 0.1 0.6 0.7 -0.1
Medication for hormone replacement therapy 0.5 0.6 3.0 -0.2 -0.1 -1.7 -0.6 -0.3 0.4 -0.5
Vitamin and mineral supplements 2.1 2.8 6.4 -1.5 2.5 2.0 0.3 2.3 1.3 0.2
Supplements: Zinc 2.1 2.3 7.1 0.7 -0.7 -2.7 -1.7 -1.5 -1.1 -1.1
Medication: Co-codamol 1.2 1.4 6.6 -2.6 0.7 1.0 0.4 -0.5 -0.7 -1.1
Medication: Metformin 1.3 1.8 4.5 -0.2 -1.4 -0.7 -0.7 -1.7 -2.1 -1.4
Diabetes (father) 0.6 0.7 1.5 0.6 -0.8 -1.2 -0.6 0.4 -0.9 -1.0
Diabetes (mother) 0.5 0.6 1.3 1.0 0.4 0.5 0.5 1.1 -0.8 0.8
Severe depression (siblings) 0.3 0.3 1.2 0.5 -0.3 -0.4 -0.2 -0.3 -1.1 -0.7
Pack years adult smoking proportion 0.7 1.1 2.1 -0.8 1.3 1.0 -0.0 1.4 1.4 -0.4
Impedance of leg (right) 0.2 1.0 4.6 0.3 1.2 -2.1 -0.0 0.1 -0.4 -0.7
Leg fat-free mass (left) 0.0 0.3 0.7 -0.1 -0.7 0.1 -0.8 -0.0 0.7 -0.3
Trunk fat percentage 0.3 1.4 4.4 -1.4 2.1 0.8 -0.8 1.1 0.6 -0.1
Hand grip strength (right) 0.8 2.1 6.8 2.6 0.5 -1.2 0.9 0.5 1.4 1.9
Townsend deprivation index at recruitment 1.7 2.4 4.6 -0.5 -1.9 -0.4 -1.9 -2.1 -2.1 0.3
Current tobacco smoking 0.4 0.6 2.0 0.2 0.7 0.7 -0.7 1.0 -1.4 0.4
Average weekly fortified wine intake 0.7 0.8 1.8 1.2 -0.2 1.0 1.4 -0.0 0.1 1.1
Maternal smoking around birth 1.1 1.5 4.6 -1.2 1.5 2.1 0.6 1.0 0.6 -0.9
Fed-up feelings 0.8 1.5 3.6 0.8 -1.8 1.9 -1.1 -0.0 -0.8 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 2.0 -0.3 -0.8 1.4 -0.2 -0.3 -0.7 -0.3
Relative age voice broke 0.2 0.4 1.3 0.6 -0.7 -0.5 0.2 -1.1 -0.5 -0.0
Taking other prescription medications 0.9 1.3 3.8 -1.4 1.6 1.9 0.8 0.3 0.1 0.7
Age when periods started (menarche) 1.3 3.2 12.3 -0.4 -0.5 -3.5 0.0 -2.2 -1.7 -1.2
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 1.5 -0.5 -0.0 -1.2 -1.1 -0.8 0.1 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.4 -1.5 1.0 0.4 1.1 0.3 0.3 -1.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.0 0.2 -0.2 1.0 -0.1 1.0 0.1 0.0
Qualifications: CSEs or equivalent 1.5 2.0 8.7 3.0 -1.1 -1.4 -0.1 -0.9 -1.0 0.0
Serious illness, injury or assault to yourself 1.9 2.3 8.6 -1.5 0.6 2.9 1.7 1.3 -0.3 0.2
High blood pressure 1.5 4.3 9.4 -3.1 2.2 3.0 1.1 1.5 1.3 1.2
Hayfever, allergic rhinitis or eczema 0.7 1.6 2.7 -0.6 -1.2 -1.6 -1.4 -1.2 -1.1 -1.4
Multivitamins +/- minerals 1.3 1.6 3.8 1.7 -1.9 -0.9 0.0 -1.6 -1.1 0.1
Stomach or abdominal pain in last month 1.4 1.7 6.1 -0.2 0.7 2.5 1.5 0.9 -0.1 1.5
Supplements: Glucosamine 1.8 2.3 7.6 0.1 -0.7 -1.4 -0.5 -2.3 -2.8 -0.8
Diverticular disease/diverticulitis (self-reported) 4.0 4.8 10.9 0.9 2.5 2.3 0.4 3.3 2.3 2.1
Medication: Atenolol 0.8 1.0 3.4 -1.4 -0.2 -0.1 -1.8 0.4 0.3 1.2
Medication: Levothyroxine sodium 2.2 3.7 10.7 -1.7 3.3 1.2 1.7 1.4 2.5 0.4
Sitting height 0.2 1.8 9.3 0.4 0.8 -1.4 -0.1 0.3 3.0 0.4
Chronic bronchitis/emphysema (father) 1.2 1.4 5.2 0.2 1.0 0.9 -0.6 0.2 2.3 1.5
High blood pressure (mother) 1.0 1.4 5.2 -0.9 -0.4 1.4 1.0 0.6 -0.5 2.3
Body mass index (BMI) 0.4 1.8 8.3 -1.1 1.0 2.9 -0.1 1.2 0.4 -0.4
Impedance of leg (left) 0.3 1.2 7.2 0.3 0.9 -2.7 -0.5 -0.3 -0.3 -0.4
Leg predicted mass (left) 0.0 0.3 0.8 -0.1 -0.6 0.1 -0.9 -0.1 0.7 -0.3
Trunk fat mass 0.3 1.2 3.0 -1.4 1.7 0.8 -0.9 1.0 0.9 -0.3
Waist circumference 0.2 0.8 2.4 -1.2 0.1 1.5 -1.0 0.3 -0.7 0.4
Number of incorrect matches in round 0.7 1.2 3.6 -1.9 1.1 0.2 -1.3 0.8 1.0 0.3
Past tobacco smoking 0.6 1.1 2.2 1.5 -1.3 -0.4 -0.9 -0.8 0.3 1.5
Alcohol usually taken with meals 0.3 0.5 1.4 0.1 -0.7 -0.2 -1.2 -0.8 -0.4 -0.7
Nervous feelings 0.8 1.5 3.7 -1.1 0.4 1.2 0.2 1.3 1.5 1.9
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.2 -0.1 -0.7 0.9 -1.1 -0.9 0.1 -0.0
Hearing difficulty/problems with background noise 1.1 1.7 4.2 -2.1 0.1 1.8 0.6 -0.5 -1.7 -1.1
Hair/balding pattern: Pattern 2 0.4 0.6 1.9 -0.6 1.4 -0.2 0.3 0.7 0.8 0.4
Had menopause 0.9 1.1 3.6 -1.7 1.9 0.2 -1.0 -0.3 -0.4 -0.4
Had other major operations 0.7 0.9 2.4 0.7 -0.8 -1.6 0.6 -1.0 -1.2 0.5
Forced vital capacity (FVC) 0.3 1.2 6.0 1.2 -0.4 -2.4 0.3 -1.0 0.2 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.1 -1.0 -0.1 -0.1 1.1 0.0 0.3 -0.8
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 1.8 1.3 -0.3 1.0 -0.4 -1.1 -1.0 -0.5
Qualifications: None of the above 1.0 2.0 7.3 -2.2 1.0 2.7 0.5 0.7 -0.2 -0.3
Financial difficulties in last 2 years 0.8 1.1 2.2 1.1 -1.0 -0.7 -0.3 -0.7 -1.5 -1.5
Mouth/teeth dental problems 1.4 2.2 11.6 3.4 -1.2 -0.4 -0.8 0.4 1.1 0.6
Heart attack 3.2 4.1 8.8 -1.6 1.1 3.0 2.6 2.3 1.6 1.2
Allergy 0.3 0.7 2.4 1.6 -0.6 0.0 1.2 -0.7 -0.5 0.1
Pain all over the body in last month 0.9 1.0 1.9 -1.4 0.3 0.5 0.9 1.3 1.4 -0.2
Diabetes (self-reported) 1.1 1.6 4.5 -0.3 -1.4 -0.6 0.3 -1.7 -2.1 -1.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 2.2 -0.2 -0.6 -1.0 -1.5 0.4 0.2 -0.2
Medication: Ramipril 0.5 0.7 2.8 -1.7 0.2 0.5 -1.0 0.9 0.2 -0.2
Medication: Simvastatin 0.7 1.0 2.4 -0.7 1.5 1.5 1.4 0.2 -0.6 -0.1
Fluid intelligence score 0.2 0.4 0.9 0.7 -0.2 -0.7 -1.0 -0.9 -0.7 -0.1
Illnesses of siblings 1.6 2.2 5.6 2.4 -1.3 -1.7 -1.4 0.1 -1.1 -1.4
Neuroticism score 0.7 1.4 3.6 0.0 -1.4 1.9 -1.8 -0.5 -0.5 0.6
Weight 0.1 0.6 1.2 -0.5 0.6 1.1 -0.8 0.9 1.1 -0.4
Impedance of arm (right) 0.3 1.5 8.7 0.1 0.4 -3.0 -0.8 -0.4 -0.8 0.4
Arm fat percentage (right) 0.4 1.5 3.6 -1.3 1.8 1.9 -0.4 1.2 0.4 -0.5
Trunk fat-free mass 0.1 0.5 1.2 0.4 -1.0 -0.1 -0.7 -0.3 1.1 -0.5
Hip circumference 0.2 0.8 2.3 -0.6 0.9 1.5 -0.4 0.9 0.7 -0.7
Time employed in main current job 0.7 0.8 2.5 -1.6 0.3 0.5 -1.2 0.4 1.1 -0.1
Alcohol intake versus 10 years previously 0.6 0.9 3.8 -1.2 -0.1 2.0 -1.0 0.1 0.4 0.1
Father’s age at death 0.7 1.0 2.2 -0.8 -1.0 -1.2 -0.6 -1.5 -0.4 -1.0
Worrier / anxious feelings 0.9 1.8 4.6 -2.1 -0.5 1.2 -1.9 -0.0 -0.3 1.6
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 1.0 0.5 -0.3 -0.7 0.5 -0.2 0.8 -1.0
Falls in the last year 1.8 2.4 6.0 1.9 -1.5 -0.2 -0.3 -0.8 -2.4 -2.1
Hair/balding pattern: Pattern 3 1.3 1.9 6.2 2.5 -2.0 -0.2 -0.4 -1.5 -0.3 1.0
Number of live births 1.1 1.5 6.7 0.0 0.8 1.1 0.9 2.6 1.1 0.4
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 5.6 0.5 -0.3 -2.4 -0.2 -0.6 0.1 -0.0
Pulse rate 0.5 0.9 1.8 1.1 -0.5 -1.3 0.2 -1.1 -0.3 -1.3
Happiness 1.2 1.4 4.9 0.4 -1.0 0.4 -1.2 -2.2 -1.5 0.4
Noisy workplace 0.7 0.9 2.2 -1.5 0.6 -0.3 -1.2 0.8 -0.5 -0.9
Qualifications: A levels/AS levels or equivalent 0.2 0.5 2.1 0.3 -0.8 -1.4 -0.3 0.0 -0.5 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.8 1.7 -1.3 -0.5 0.4 0.3 -0.2 -1.0
Mouth/teeth dental problems: Dentures 1.0 1.7 6.3 -2.5 1.8 0.8 0.7 -0.9 -0.1 0.2
Asthma 1.5 2.9 7.2 -1.1 2.7 1.5 0.1 1.4 2.4 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.7 -0.9 -0.5 -1.7 -0.7 0.2 0.9 -1.2
Medication: Cholesterol lowering 0.7 1.0 2.5 -1.2 0.8 1.6 1.0 0.9 -0.5 0.7
Depression (self-reported) 0.5 0.7 2.9 0.5 0.9 -0.3 -0.0 0.7 1.7 -0.4
Medication: Lansoprazole 0.4 0.5 1.8 -0.4 0.4 0.4 1.4 0.3 -0.6 -0.7
Prospective memory result 0.6 0.7 2.0 -0.6 0.7 0.8 -0.0 -0.1 1.4 1.2
Lung cancer (father) 0.6 0.8 1.9 -1.4 0.3 0.8 -0.7 -0.7 -0.3 -1.3
Illnesses of mother 0.5 0.7 3.0 0.8 0.9 -0.1 -0.5 -0.0 0.0 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.1 0.2 -0.5 -1.8 -0.5 -1.5 -0.3 -0.3
Pulse wave Arterial Stiffness index 0.7 0.9 3.0 1.7 0.4 -0.2 0.3 0.7 0.8 1.3
Impedance of arm (left) 0.4 2.1 12.7 0.5 0.3 -3.6 -0.8 -0.3 -0.6 0.5
Arm fat mass (right) 0.3 1.1 3.0 -0.8 1.2 1.7 -0.6 1.1 0.8 -0.3
Trunk predicted mass 0.1 0.5 1.2 0.4 -1.1 -0.0 -0.8 -0.4 1.1 -0.5
Standing height 0.3 3.1 14.0 1.4 -0.7 -3.7 -1.5 -0.6 1.6 0.3
Length of working week for main job 1.2 1.3 3.7 1.4 -1.9 0.6 0.1 -0.3 -1.6 -0.7
Exposure to tobacco smoke at home 1.3 1.5 4.4 0.7 -0.2 1.8 1.2 -0.9 -2.1 -0.2
Breastfed as a baby 0.1 0.1 0.3 0.1 0.1 0.3 0.5 0.6 -0.1 0.3
Tense / ‘highly strung’ 0.9 1.5 7.6 0.2 -0.3 2.8 1.0 -0.3 -0.1 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.1 0.6 -1.0 0.4 -0.6 0.3 -0.0 0.8
Hair/balding pattern: Pattern 4 1.1 2.6 10.1 -3.2 -0.1 -0.7 -0.7 -1.2 -1.0 -2.3
Birth weight of first child 0.7 1.3 3.7 0.4 -0.2 -1.9 1.0 -1.6 -1.2 -0.5
Peak expiratory flow (PEF) 0.6 1.4 4.0 -0.0 0.5 -2.0 -0.2 -0.6 -1.7 -1.5
Pulse wave reflection index 0.7 0.8 3.2 1.4 0.3 0.3 0.1 0.6 0.5 1.8
Ever highly irritable/argumentative for 2 days 0.8 0.9 2.4 1.1 -1.1 -0.1 -0.3 -0.7 -1.0 -1.6
Loud music exposure frequency 0.8 0.9 3.6 1.0 -0.5 -0.5 -0.3 0.8 1.9 0.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.3 1.1 -0.8 -1.0 0.7 -0.8 0.9 -0.0
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.8 -1.6 -0.2 0.8 -0.0 -0.5 -0.7 -1.7
Blood clot in the leg (DVT) 1.0 1.3 4.0 0.8 -0.3 0.6 -0.3 2.0 1.9 0.7
Medication: Paracetamol 0.4 0.7 2.2 -1.5 -1.0 0.2 -0.7 0.1 -0.2 -1.0
Headache pain in last month 0.5 0.8 2.5 0.0 -1.2 -0.2 -0.9 0.6 -0.8 -1.6
Medication for cholesterol, blood pressure or diabetes 0.6 1.1 4.3 2.1 -0.8 -1.1 -0.4 -0.9 -0.2 -0.5
Glaucoma (self-reported) 1.8 2.1 5.2 0.4 -2.3 -2.0 -1.6 -1.4 -0.6 -0.8
Gout (self-reported) 0.8 1.2 3.1 -0.5 0.2 1.8 -1.2 -0.8 -1.0 -1.3
Hypothyroidism/myxoedema (self-reported) 2.5 4.8 11.3 -1.5 3.1 1.8 1.3 2.2 3.4 0.8
Medication: Amlodipine 0.7 1.0 3.5 -1.9 0.4 0.7 -0.4 -0.1 -1.4 0.5
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.5 0.5 0.7 0.3 0.1 0.2 0.0 -0.3
Birth weight 1.7 3.7 7.3 1.6 -2.1 -2.7 -0.6 -2.4 -1.9 -1.3
Chronic bronchitis/emphysema (mother) 1.3 1.5 4.8 2.2 -1.8 -0.8 -0.1 0.8 0.7 0.8
High blood pressure (siblings) 1.4 2.0 4.3 -1.2 0.6 1.8 2.1 -0.5 -0.6 2.0
Forced vital capacity (FVC), Best measure 0.3 1.1 3.9 0.9 -0.6 -2.0 -0.2 -1.5 -0.0 -0.1
Body fat percentage 0.5 2.1 5.7 -1.8 2.4 1.6 -0.6 1.3 0.6 -0.6
Leg fat percentage (right) 1.0 3.7 8.9 -2.0 2.7 3.0 0.3 1.8 0.8 -1.3
Arm fat-free mass (right) 0.1 0.4 1.1 0.1 -0.7 0.5 -1.1 -0.2 0.9 -0.6
Exposure to tobacco smoke outside home 0.2 0.3 0.9 1.0 -0.2 -0.1 0.4 0.5 0.0 0.7
Comparative body size at age 10 0.3 0.9 2.7 -1.0 -0.1 0.7 0.1 -1.0 -0.9 -1.6
Number of full brothers 1.0 1.3 3.2 -0.8 -0.7 1.8 -0.4 -1.2 -1.1 -1.3
Worry too long after embarrassment 0.3 0.6 3.3 0.1 -0.1 1.8 -0.5 -0.1 0.3 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.6 0.8 -0.2 -0.2 -0.8 -0.1 0.1 0.3
Wheeze or whistling in the chest in last year 0.7 1.2 3.2 -0.9 1.8 -0.1 -1.7 -1.2 0.4 0.1
Number of children fathered 1.8 2.1 7.3 -2.7 0.5 2.2 0.9 0.6 0.9 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 3.4 -0.2 1.4 1.8 1.1 0.7 1.2 1.9
Age at first live birth 0.7 1.3 2.3 1.5 -0.9 -1.2 -0.4 -1.5 -1.1 -1.0
Pulse wave peak to peak time 0.6 0.7 2.1 -1.4 -0.3 -0.1 -0.2 -0.7 -0.8 -1.2
Health satisfaction 0.3 0.4 1.8 0.2 0.9 -0.1 1.3 -0.0 -0.5 0.4
Shortness of breath walking on level ground 0.5 0.6 1.3 0.9 0.2 1.1 0.6 0.7 0.3 1.1
Qualifications: College or University degree 0.9 2.9 13.1 1.8 -1.1 -3.6 -0.5 -1.4 -0.7 -0.2
Eye problems/disorders: None of the above 0.3 0.4 1.6 0.6 1.3 -0.4 0.1 0.1 -0.7 -0.1
Mouth/teeth dental problems: Loose teeth 1.0 1.1 5.7 -0.6 2.4 -0.6 0.8 0.7 0.6 -0.2
Emphysema/chronic bronchitis 0.8 1.0 2.5 -1.0 -0.3 -1.1 -1.6 -0.1 0.3 -1.3
Medication for pain relief, constipation, heartburn 0.3 0.4 1.0 1.0 0.4 -0.8 0.3 -0.2 0.5 0.9
Neck or shoulder pain in last month 2.0 2.9 13.6 -0.1 -1.1 -0.3 -1.3 -1.4 -1.2 -3.7
Medication: Blood pressure 0.6 1.0 3.1 -1.8 0.1 0.7 0.4 1.2 0.6 1.1
Angina (self-reported) 0.7 1.0 3.4 -1.9 1.3 0.0 -0.0 0.9 0.8 0.0
Migraine (self-reported) 0.8 1.0 3.6 -0.4 0.3 1.9 0.7 1.3 0.1 -1.1
Medication: Ibuprofen 0.7 0.8 3.8 -0.3 -0.5 -1.9 -0.5 0.3 0.1 -1.1
Medication: Allopurinol 0.8 1.0 3.7 0.1 -0.2 1.0 -0.6 -0.9 -1.9 -1.2
Medication: Omeprazole 0.7 0.9 2.2 1.5 -0.9 -0.6 -0.7 -0.9 -0.9 -0.7
Medication: Seretide 50 evohaler 1.6 1.8 6.9 0.5 1.5 2.6 -0.8 0.8 1.1 0.8
Mean time to correctly identify matches 1.0 1.9 4.9 -1.7 2.2 1.9 -0.8 1.0 -0.1 -0.0
Heart disease (mother) 4.1 4.9 11.6 -2.3 2.2 2.8 1.1 0.8 3.4 1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 4.0 -2.0 1.0 -0.3 1.8 -0.3 -0.6 -0.9
Whole body fat mass 0.3 1.4 2.5 -1.4 1.6 1.5 -0.8 1.1 0.9 -0.6
Leg fat mass (right) 0.5 2.0 4.2 -1.6 1.8 2.0 -0.2 1.2 0.9 -1.2
Arm predicted mass (right) 0.1 0.6 1.6 -0.1 -0.6 0.5 -1.3 -0.3 0.9 -0.9
Pulse rate, automated reading 0.3 1.1 2.9 -0.7 1.7 0.9 1.0 1.1 0.9 -0.8
Alcohol intake frequency. 0.9 2.1 9.2 0.8 -3.0 1.8 -1.1 -0.5 -0.3 -0.4
Comparative height size at age 10 0.4 2.1 7.9 0.0 -0.2 -2.3 -2.8 -0.8 0.8 -0.7
Number of full sisters 0.3 0.3 0.8 0.2 0.8 0.6 0.9 0.5 0.2 -0.4
Suffer from ‘nerves’ 0.4 0.6 1.2 0.6 -1.0 0.7 -0.9 -0.6 -1.1 -0.4
Overall health rating 0.8 1.7 4.9 -2.1 1.1 2.2 0.9 0.7 0.5 -0.0
Chest pain or discomfort 1.5 2.1 5.8 -1.4 1.8 2.4 0.0 1.6 0.6 1.2
Had major operations 1.0 1.1 3.9 -0.6 0.3 0.8 1.6 2.0 0.2 -0.4
Age at last live birth 0.7 1.1 3.8 1.9 -0.3 1.0 1.0 0.7 -0.8 0.6
Family relationship satisfaction 1.7 2.1 5.4 1.8 -1.2 -1.1 -0.0 -1.6 -0.9 2.3
Leg pain on walking 0.8 1.0 3.3 -0.9 1.8 -0.4 -0.1 -1.1 0.9 -0.8
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 4.6 -1.3 2.1 1.7 0.9 0.9 0.9 0.4
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.3 -0.1 -0.4 0.8 1.2 -1.3 0.1 -1.5
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.6 0.7 0.5 -0.6 -0.8 -0.7 0.7 0.6
Medication: Aspirin 0.9 1.2 4.7 -2.2 1.0 0.7 0.7 0.5 -1.1 -0.4
Supplements: Vitamin C 0.7 0.8 4.1 0.5 -0.4 -2.0 0.5 -0.6 0.0 0.5
Knee pain experienced in last month 1.2 1.9 10.2 -0.6 1.0 3.2 -0.3 0.2 -1.3 -0.3
Hypertension (Self-reported) 1.6 4.6 10.6 -3.3 2.0 3.1 1.1 1.8 1.2 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 3.1 1.8 0.2 0.4 0.4 0.8 -1.1 0.9
Illnesses of father: Heart disease 0.6 0.8 1.8 0.1 0.7 0.7 1.3 -1.0 -1.0 0.8
Illnesses of siblings: Diabetes 2.4 3.0 5.7 -2.1 1.6 2.0 1.7 0.9 2.4 0.1
Smoking status: Previous 0.8 1.1 2.3 -1.5 1.2 0.5 1.1 0.7 0.6 -1.3
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 11.2 1.6 -1.3 -3.4 -0.6 -1.7 -0.8 -1.2
Whole body fat-free mass 0.1 0.5 1.0 0.2 -1.0 -0.1 -1.0 -0.4 0.9 -0.5
Leg fat-free mass (right) 0.1 0.6 1.6 0.3 -1.1 -0.4 -1.3 -0.5 0.7 -0.3
Arm fat percentage (left) 0.3 1.2 3.0 -1.2 1.6 1.7 -0.6 1.1 0.4 -0.5
Average weekly red wine intake 1.4 2.0 6.6 -1.8 1.7 -0.2 0.0 1.1 2.6 -0.5
Handedness (chirality/laterality): Left-handed 2.2 2.7 6.1 -2.5 1.8 1.9 0.4 0.5 1.3 1.8
Mood swings 0.8 1.5 2.6 -1.2 -1.2 1.4 -1.6 -1.5 0.8 0.3
Loneliness, isolation 1.2 1.7 3.8 -0.1 -1.6 -1.0 -1.9 -1.3 -1.7 -0.3
Long-standing illness, disability or infirmity 0.7 1.1 3.0 -1.6 0.9 0.9 -0.1 1.7 0.5 -0.6
Ever had bowel cancer screening 0.9 1.0 3.9 -2.0 0.1 1.2 0.7 -1.1 -0.4 -0.2
Diabetes diagnosed by doctor 0.8 1.2 3.5 -0.6 -0.7 -0.4 0.8 -1.5 -1.9 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.7 1.3 -1.0 0.4 -1.1 0.2 0.8 0.4
Friendships satisfaction 2.7 3.3 5.7 1.4 -2.1 -1.9 -1.6 -2.4 -2.2 0.3
Qualifications: nursing, teaching 1.0 1.5 4.0 1.5 -1.2 -2.0 -0.5 -0.4 -1.3 0.8
Commuting to job workplace: Walk 0.8 0.8 3.7 0.1 1.0 0.5 -0.3 1.9 0.4 0.7
Eye problems/disorders: Cataract 1.0 1.1 3.8 -0.7 -0.3 0.5 -1.0 -1.5 -0.1 -1.9
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 4.8 -2.2 -0.2 1.0 0.6 0.1 -1.6 -0.0
Medication for cholesterol 1.5 2.3 6.6 0.5 -2.6 -2.0 -1.6 -1.2 -1.1 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.3 -0.2 1.4 1.5 0.6 1.5 -0.2 0.2
Back pain experienced in last month 1.2 1.7 6.2 -1.7 0.3 -0.4 -0.4 -1.0 -1.3 -2.5
Mineral and other dietary supplements 3.8 5.1 10.3 0.9 1.8 3.2 1.0 3.0 2.6 2.0
Breast cancer (self-reported) 0.8 1.0 2.8 -0.6 1.5 0.4 1.0 -0.2 0.3 -1.7
Asthma (self-reported) 1.2 2.4 5.3 -0.7 2.3 1.3 0.2 1.4 2.2 1.6
Osteoporosis (self-reported) 0.7 0.9 2.0 1.1 0.7 0.7 0.9 0.8 0.8 1.4
Osteoarthritis (self-reported) 1.1 1.4 3.5 -0.5 1.2 1.9 0.4 -0.9 -1.4 -1.3
Medication: Aspirin 0.8 1.1 4.6 -2.2 1.0 0.8 0.3 0.9 -0.5 -0.4
Medication: Gliclazide 0.6 0.6 3.6 -0.4 -0.8 0.0 0.2 -0.1 -1.9 0.2
Illnesses of father: None of the above (group 1) 0.3 0.4 1.5 -0.2 -1.2 -0.5 0.3 -0.1 -0.8 -0.3
Smoking status: Current 0.5 0.7 2.9 0.3 0.4 0.7 -0.8 0.9 -1.7 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 3.6 -0.8 1.2 0.4 1.9 0.7 1.8 1.2
Whole body water mass 0.1 0.4 1.0 0.2 -1.0 0.0 -1.0 -0.3 0.8 -0.3
Leg predicted mass (right) 0.1 0.5 1.4 0.2 -1.0 -0.4 -1.2 -0.5 0.7 -0.3
Arm fat mass (left) 0.2 0.9 2.9 -0.7 1.2 1.7 -0.7 0.9 0.6 -0.2
Number of self-reported non-cancer illnesses 2.7 4.7 8.9 -2.0 3.0 2.7 1.6 2.4 1.3 1.6
Average weekly champagne plus white wine intake 2.2 3.0 6.3 -0.6 -1.6 -1.1 -1.8 -2.4 -2.5 -1.2
Miserableness 0.8 1.3 5.0 0.6 -2.2 0.2 -1.5 -0.6 -1.1 0.1
Guilty feelings 0.8 1.2 3.5 -0.6 -1.2 0.5 -1.9 -1.1 1.3 0.0
Wears glasses or contact lenses 3.5 4.1 8.0 -2.2 2.5 1.6 -0.6 2.8 2.0 1.6
Ever taken oral contraceptive pill 0.4 0.4 1.3 -0.1 -0.5 -0.9 -0.0 -0.5 1.1 0.4
Hearing aid user 0.4 0.5 2.3 -0.0 0.1 -0.3 -0.8 -0.3 -0.4 -1.5
Mother’s age at death 0.7 0.9 4.6 -0.2 0.5 0.5 2.1 -0.9 -0.4 -0.4
Financial situation satisfaction 0.5 0.6 1.5 0.2 0.5 0.3 0.3 -1.2 -1.0 -1.1
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.1 -0.9 1.0 0.7 0.6 0.6 0.6 -0.3
Commuting to job workplace: Public transport 0.6 0.7 2.8 0.1 0.5 -0.5 -0.1 1.7 0.8 1.1
Eye problems/disorders: Glaucoma 1.5 1.7 6.7 0.4 -2.6 -1.2 -1.5 -0.7 -0.7 -0.7
Medication: Blood pressure 1.2 2.2 5.7 -2.1 2.4 2.1 0.3 0.5 0.0 0.5
Pain type(s) experienced in last month: Hip pain 1.2 1.5 5.3 -1.5 0.9 2.3 -0.2 -0.4 0.5 -1.2
Supplements: Fish oil (including cod liver oil) 2.8 3.7 7.3 -1.2 -1.8 -2.3 -0.7 -2.7 -1.6 -2.4
High cholesterol (Self-reported) 0.4 0.8 1.8 -0.7 1.0 1.1 1.3 0.2 -0.8 -0.3
Medication: Bendroflumethiazide 3.2 4.8 14.2 -1.8 3.3 3.8 0.9 2.0 0.6 0.4
Medication: Paracetamol 0.5 0.8 1.6 -1.3 -1.1 -0.1 -1.3 0.4 -0.2 -0.9
Medication: Lisinopril 1.2 1.5 5.3 0.1 -0.2 0.1 -1.6 -1.0 -1.4 -2.3
Medication: Atorvastatin 0.6 0.8 1.6 -1.3 0.7 0.8 1.0 0.4 -0.3 1.2
Illnesses of father: High blood pressure 0.2 0.2 0.9 -0.2 0.9 0.5 -0.3 0.3 -0.2 0.1
Alcohol drinker status: Never 1.7 2.0 7.7 0.1 -2.8 -1.2 -0.8 -1.7 -0.9 -0.9
Ever smoked 0.8 1.5 3.4 -1.4 1.9 0.8 0.5 1.2 0.1 -1.6
Basal metabolic rate 0.1 0.4 1.1 0.2 -0.6 0.3 -1.0 -0.0 1.0 -0.4
Leg fat percentage (left) 0.8 3.0 7.1 -1.8 2.5 2.7 -0.1 1.7 0.8 -1.0
Arm fat-free mass (left) 0.1 0.4 1.1 -0.0 -0.2 1.0 -0.7 0.1 0.8 -0.5
Number of operations (self-reported) 0.3 0.4 0.9 0.8 -0.3 -0.9 0.4 0.8 -0.7 0.0
Average weekly beer plus cider intake 0.8 1.1 4.3 -0.2 1.1 0.7 0.3 2.1 -0.1 1.2
Irritability 0.5 0.8 2.4 -1.1 -0.5 0.7 -1.5 -0.6 -1.1 -0.3
Risk taking 0.8 1.1 3.6 1.2 -1.0 0.1 -0.2 -1.4 -1.9 0.0
Ever had prostate specific antigen (PSA) test 0.8 0.9 3.5 -1.9 0.9 -0.1 -0.9 0.1 -0.0 -1.1
Fractured/broken bones in last 5 years 0.4 0.5 1.8 0.8 0.5 1.3 0.2 1.0 -0.2 0.1
Age started oral contraceptive pill 0.6 0.7 1.4 -0.2 -0.5 0.7 -0.6 -1.2 -1.0 -1.1
Diastolic blood pressure, automated reading 1.9 5.9 11.4 -2.7 3.4 3.3 -1.0 1.9 2.6 0.2
Ever depressed for a whole week 0.9 1.1 2.1 0.8 -1.0 1.4 1.2 -0.3 -1.5 0.7
Unable to work because of sickness or disability 0.8 1.0 2.4 -0.8 -0.1 0.2 -1.5 1.1 -1.4 -0.8
Commuting to job workplace: Cycle 1.3 1.6 4.9 1.6 -1.0 -2.2 -0.4 0.6 -0.7 1.4
Myopia 0.9 1.3 5.2 -0.6 -0.1 -2.3 -0.2 -0.7 -1.5 1.0
Vascular/heart problems diagnosed by doctor 2.0 5.4 13.4 3.7 -2.6 -3.2 -1.1 -1.7 -1.3 -1.2
Cholesterol lowering medication 1.8 2.6 6.6 -0.5 2.1 2.6 2.5 0.5 -0.2 -0.8
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 2.8 1.7 -0.9 -0.4 -0.9 -1.3 -1.3 -0.4
Pain experienced in last month 0.8 1.4 5.2 1.2 0.4 -2.3 -0.2 -0.2 0.2 1.7
Supplements: Calcium 1.6 1.7 6.8 0.4 -1.1 -1.0 -0.1 -2.6 -1.6 -0.0
Basal cell carcinoma (self-reported) 1.0 1.2 6.7 -0.1 2.6 0.9 0.6 0.5 -0.4 -0.2
Heart attack/myocardial infarction (self-reported) 3.0 3.9 8.9 -1.5 0.9 3.0 2.6 2.3 1.3 1.2
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 4.1 0.6 -0.2 0.6 -0.3 2.0 1.6 0.5
Heart disease (siblings) 0.6 0.7 3.5 -1.9 -1.0 0.5 -0.1 -0.2 -0.2 -0.1
Alcohol drinker status: Previous 0.5 0.6 2.5 0.7 -0.3 1.6 0.1 1.0 0.1 0.1
Pack years of smoking 1.0 1.5 3.0 -1.2 1.7 1.3 -0.2 1.4 1.4 -0.6
Impedance of whole body 0.3 1.6 9.6 0.3 1.0 -3.1 -0.7 -0.0 -0.3 0.2
Leg fat mass (left) 0.5 1.8 3.6 -1.7 1.7 1.9 -0.4 1.2 0.9 -1.1
Arm predicted mass (left) 0.1 0.4 1.1 -0.0 -0.5 0.6 -1.0 -0.1 0.7 -0.8