TWAS hub - PLN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0893	0.0347	2.2e-03	0.047	NA	0.022	NA	0.029	1.3e-04	NA	7.5e-03	NA	0.00250
2	GTEx	Brain Hippocampus	0.6047	0.1386	2.4e-05	0.009	NA	0.228	NA	0.059	1.9e-01	NA	4.6e-06	NA	0.01700
3	NTR	Blood	0.0217	0.0096	5.5e-04	0.015	0.012	0.012	0.015	0.011	7.6e-06	5e-05	5.8e-05	7.5e-06	0.00011

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3
Pulse rate, automated reading	9.2	29.8	78.0	3.4	-8.8
Diastolic blood pressure, automated reading	4.8	14.9	30.1	3.8	-5.5
Pulse rate	4.5	7.6	18.7	2.1	-4.3
Average weekly fortified wine intake	4.0	4.6	8.7	2.3	-2.9
Suffer from ‘nerves’	3.9	6.2	18.1	0.7	-4.2
Tense / ‘highly strung’	3.8	6.2	12.8	2.4	-3.6
Ever taken oral contraceptive pill	3.7	4.1	8.0	-2.1	2.8
High blood pressure	3.3	9.2	14.1	3.8	-3.7
Supplements: Glucosamine	3.2	4.1	7.0	2.7	-2.3
Hypertension (Self-reported)	3.1	8.5	13.0	3.6	-3.5
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	5.3	-2.3	2.0
Vascular/heart problems diagnosed by doctor	2.9	8.0	12.8	-3.6	3.3
Systolic Blood Pressure	2.7	13.5	33.7	5.8	-2.6
Eye problems/disorders: Cataract	2.7	3.1	5.5	-1.9	2.3
Illnesses of father: None of the above (group 1)	2.7	3.4	6.1	-2.0	2.5
Systolic blood pressure, automated reading	2.5	7.2	16.1	4.0	-2.3
Fluid intelligence score	2.5	5.1	9.9	-2.3	3.2
Medication: Blood pressure	2.4	4.7	8.9	3.0	-2.3
Type 2 Diabetes (T2D) (2012)	2.3	2.6	5.7	-1.4	2.4
Pain type(s) experienced in last month: Hip pain	2.2	2.8	6.8	1.3	-2.6
Crohns Disease (2012)	2.0	3.2	8.5	-2.9	1.1
Illnesses of father: Heart disease	2.0	2.8	5.4	1.7	-2.3
High blood pressure (mother)	1.9	2.7	6.3	2.5	-1.4
Heel T-Score	1.8	14.2	23.0	4.8	-4.4
Medication for hormone replacement therapy	1.8	2.0	4.3	-1.3	2.1
Gout (self-reported)	1.8	2.5	6.2	1.2	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	4.2	-2.1	1.5
Worry (Nagel 2018)	1.7	3.6	7.7	1.7	-2.8
Lung FVC	1.7	8.8	15.2	3.3	-3.9
Frequency of depressed mood in last 2 weeks	1.7	2.4	5.6	1.3	-2.4
Ever used hormone-replacement therapy (HRT)	1.7	2.1	6.4	2.5	-0.0
Vitamin and mineral supplements	1.7	2.3	3.8	-1.7	2.0
Medication: Lisinopril	1.7	2.2	4.3	2.1	-1.5
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	4.8	-2.2	1.1
Miserableness	1.6	2.8	6.8	1.3	-2.6
Body Mass Index (BMI) (2010)	1.5	2.0	3.7	-1.9	1.6
Chronotype (morning person)	1.5	3.5	6.8	2.6	-1.9
Pain all over the body in last month	1.5	1.7	4.2	-0.9	2.0
Diabetes (mother)	1.4	1.7	3.0	-1.5	1.7
Medication: Atenolol	1.4	1.7	4.5	2.1	-0.9
Nervous feelings	1.4	2.5	4.2	1.8	-2.0
Health satisfaction	1.4	1.8	2.8	-1.6	-1.7
Asthma	1.3	2.6	5.3	-2.3	1.6
Depression (self-reported)	1.3	1.5	2.5	1.5	-1.6
Mouth/teeth dental problems: Loose teeth	1.3	1.6	3.1	1.3	1.8
Supplements: Vitamin C	1.3	1.6	3.7	1.9	-1.0
Verbal and Numeric Reasoning (VNR)	1.2	2.9	7.0	-1.3	2.6
HbA1C	1.2	1.4	3.1	-1.0	1.8
LDL Cholesterol	1.2	1.9	3.0	-1.7	1.6
Respiratory disease	1.2	2.7	4.8	-2.2	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.5	1.1	-1.9
Impedance of leg (left)	1.2	5.8	10.7	2.6	-3.3
Bipolar Disorder (2011)	1.1	1.0	3.0	0.3	1.7
Blood White Count	1.1	7.8	15.6	-2.8	3.9
Cardiovascular Disease	1.1	3.6	6.6	2.6	-2.0
Fed-up feelings	1.1	2.1	5.1	1.1	-2.3
Multivitamins +/- minerals	1.1	1.4	3.6	0.7	-1.9
Stomach or abdominal pain in last month	1.1	1.3	2.5	-1.6	-1.2
Lung cancer (father)	1.1	1.3	2.8	-1.1	1.7
Illnesses of mother	1.1	1.4	4.1	-2.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	5.1	-1.4	2.3
Breast cancer (self-reported)	1.1	1.4	3.6	-0.7	1.9
Commuting to job workplace: Cycle	1.1	1.4	2.4	-1.5	1.3
Impedance of whole body	1.1	5.8	12.0	2.3	-3.5
Coronary Artery Disease (CAD)	1.0	1.1	3.0	-1.7	-0.6
Serious illness, injury or assault to yourself	1.0	1.3	2.5	-1.6	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.7	-1.3	1.2
Impedance of arm (left)	1.0	4.8	11.4	1.8	-3.4
Pulse wave peak to peak time	1.0	1.2	2.4	1.1	1.6
Medication: Seretide 50 evohaler	1.0	1.1	2.1	-1.5	1.1
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.2	1.5	1.1
Back pain experienced in last month	1.0	1.5	3.6	0.9	-1.9
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.3	1.8	0.4
Age started oral contraceptive pill	1.0	1.2	3.4	1.8	-0.4
Depression (Nagel 2018)	0.9	1.3	3.4	0.7	-1.8
Major Depression (MDD)	0.9	1.2	3.3	-1.8	-0.4
Neuroticism	0.9	2.2	5.2	1.3	-2.3
Average weekly spirits intake	0.9	1.1	3.2	1.8	-0.2
Impedance of leg (right)	0.9	4.6	8.1	2.4	-2.9
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.6	1.2	1.3
Leg predicted mass (left)	0.9	4.6	7.5	-2.5	2.7
Had menopause	0.9	1.2	2.6	1.6	-0.9
Medication: Ramipril	0.9	1.2	2.3	1.5	-1.1
Neuroticism score	0.9	1.8	5.0	0.7	-2.2
Glaucoma (self-reported)	0.9	1.1	3.1	-0.2	-1.8
Shortness of breath walking on level ground	0.9	1.1	2.6	-1.6	-0.9
Medication: Allopurinol	0.9	1.2	3.4	0.5	-1.8
Medication: Omeprazole	0.9	1.1	3.2	1.8	-0.2
Asthma (self-reported)	0.9	1.8	3.7	-1.9	1.3
Leg predicted mass (right)	0.9	4.6	7.4	-2.5	2.7
Illnesses of father: High blood pressure	0.9	1.1	2.0	1.2	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.4	1.5	-1.0
Schizophrenia vs Biploar Disorder	0.8	1.1	2.1	-1.4	1.1
Reaction Time	0.8	1.4	3.0	1.1	-1.7
Hand grip strength (left)	0.8	2.1	3.6	-1.9	1.7
Leg fat-free mass (left)	0.8	4.3	6.9	-2.5	2.6
Impedance of arm (right)	0.8	3.9	9.2	1.6	-3.0
Father’s age at death	0.8	1.1	2.5	0.9	-1.6
Pulse wave Arterial Stiffness index	0.8	1.0	1.6	-1.3	-1.1
Headache pain in last month	0.8	1.4	2.5	1.6	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.2	1.5	1.0
Eye problems/disorders: None of the above	0.8	0.9	1.9	1.4	-0.9
Emphysema/chronic bronchitis	0.8	0.9	2.3	-0.7	1.5
Medication: Blood pressure	0.8	1.3	2.9	1.7	-1.0
Mean time to correctly identify matches	0.8	1.6	3.6	1.1	-1.9
Whole body fat-free mass	0.8	4.7	7.8	-2.5	2.8
Leg fat-free mass (right)	0.8	4.3	6.9	-2.5	2.6
Mood swings	0.8	1.4	4.2	0.3	-2.0
Medication: Gliclazide	0.8	0.9	2.4	-1.6	-0.3
Whole body water mass	0.8	4.6	7.8	-2.5	2.8
Pain experienced in last month	0.8	1.3	2.7	-1.6	1.1
Crohns Disease (2017)	0.7	1.6	3.7	-1.9	1.0
Ever had hysterectomy (womb removed)	0.7	0.7	1.8	0.6	1.4
Trunk fat-free mass	0.7	4.3	7.1	-2.4	2.7
Trunk predicted mass	0.7	4.3	7.1	-2.4	2.7
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.1	0.7	-1.4
Heart disease (mother)	0.7	0.8	2.0	-0.7	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.6	-1.3	0.8
Mineral and other dietary supplements	0.7	1.0	2.4	-1.5	0.8
Smoking status: Current	0.7	1.1	3.2	-1.8	-0.3
Hearing aid user	0.7	0.8	2.1	0.4	1.5
High cholesterol (Self-reported)	0.7	1.2	3.0	1.7	-0.8
Basal metabolic rate	0.7	3.7	6.2	-2.2	2.5
Alcohol drinker status: Previous	0.7	0.8	1.9	-1.4	-0.8
Arm predicted mass (left)	0.7	3.4	7.0	-1.8	2.6
Intelligence (Savage-Jansen 2018)	0.6	1.8	5.5	-0.2	2.3
Alzheimer’s Disease (including proxy)	0.6	0.9	2.6	-1.6	0.3
Blood Eosinophil Count	0.6	4.9	9.7	-2.2	3.1
Number of treatments/medications taken	0.6	1.1	3.2	1.8	0.0
Supplements: Zinc	0.6	0.7	2.0	0.0	-1.4
Medication: Metformin	0.6	0.9	1.7	-1.3	1.0
Current tobacco smoking	0.6	1.0	2.8	-1.7	-0.3
Sitting height	0.6	4.1	8.6	-2.9	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.2	0.8	-1.5
Happiness	0.6	0.7	2.0	-0.4	-1.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.9	0.8	-1.4
Arm fat-free mass (right)	0.6	3.2	6.1	-1.9	2.5
Wheeze or whistling in the chest in last year	0.6	1.1	2.2	-1.0	1.5
Angina (self-reported)	0.6	0.8	1.9	0.6	1.4
Arm predicted mass (right)	0.6	2.9	5.1	-1.9	2.3
Family relationship satisfaction	0.6	0.8	2.0	0.6	-1.4
Knee pain experienced in last month	0.6	0.9	2.3	-0.7	-1.5
Smoking status: Previous	0.6	0.9	2.1	0.8	-1.4
Long-standing illness, disability or infirmity	0.6	1.0	2.9	-0.1	-1.7
Ever had bowel cancer screening	0.6	0.7	2.1	-1.4	0.2
Medication for cholesterol	0.6	0.9	2.4	-1.5	0.4
Eye problems/disorders: Glaucoma	0.6	0.7	2.2	-0.1	-1.5
Medication: Paracetamol	0.6	1.0	3.0	1.7	0.1
Arm fat-free mass (left)	0.6	2.9	5.9	-1.7	2.4
Myopia	0.6	0.9	2.8	-1.7	-0.1
Depressed Affect (Nagel 2018)	0.5	1.1	3.2	-0.2	-1.8
Neuroticism (Nagel 2018)	0.5	1.2	3.5	-0.1	-1.9
Breast Cancer	0.5	1.3	3.1	0.8	-1.8
Fasting Glucose	0.5	0.7	1.8	-1.4	0.3
Neuroticism (2016)	0.5	0.8	1.4	1.2	-1.0
Waist Hip Ratio (WHR)	0.5	2.3	4.6	-1.5	2.1
Relative age of first facial hair	0.5	1.0	2.1	-0.9	1.5
Angina	0.5	0.7	1.6	0.7	1.3
Diabetes (father)	0.5	0.6	1.1	-1.1	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	2.9	1.7	-0.5
Allergy	0.5	1.1	2.0	1.2	-1.4
Diabetes (self-reported)	0.5	0.7	2.1	-1.5	0.2
Falls in the last year	0.5	0.6	1.8	-1.3	0.3
Exposure to tobacco smoke at home	0.5	0.6	1.6	1.3	-0.3
Hair/balding pattern: Pattern 4	0.5	1.1	2.5	-1.6	-0.9
Birth weight of first child	0.5	1.0	2.1	-0.9	1.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.6	-1.0	1.2
Age at last live birth	0.5	0.7	1.3	-0.8	1.1
Illnesses of siblings: Diabetes	0.5	0.6	1.3	-1.1	0.8
Commuting to job workplace: Public transport	0.5	0.6	1.7	-0.4	-1.3
Ever depressed for a whole week	0.5	0.6	1.6	-1.3	0.4
Schizophrenia (2018)	0.4	0.8	2.2	-0.3	1.5
Alzheimer’s Disease (in father)	0.4	0.4	0.9	-1.0	0.5
Ovarian Cancer	0.4	0.5	1.6	-1.3	-0.2
HDL Cholesterol	0.4	0.7	1.6	-1.3	0.7
Schizophrenia (2014)	0.4	0.9	1.9	-0.9	1.4
Medication: Co-codamol	0.4	0.4	1.0	1.0	-0.5
Qualifications: None of the above	0.4	0.8	1.4	-1.2	-1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.6	0.2	1.2
Noisy workplace	0.4	0.5	1.3	1.2	0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.7	-1.3	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.5	-1.2	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.5	0.4	-1.9
Medication: Paracetamol	0.4	0.7	2.0	1.4	-0.0
Worry too long after embarrassment	0.4	0.7	1.8	-0.6	-1.4
Number of children fathered	0.4	0.4	0.7	0.7	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.8	-0.9	-0.8
Diabetes diagnosed by doctor	0.4	0.6	1.9	-1.4	0.1
Average weekly champagne plus white wine intake	0.4	0.6	1.8	-0.1	-1.3
Mother’s age at death	0.4	0.5	1.4	1.2	0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.2	0.7	1.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.5	1.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	0.2	-1.2
Heart disease (siblings)	0.4	0.5	1.5	0.1	-1.2
Pack years of smoking	0.4	0.6	1.5	0.4	-1.2
Alzheimer’s Disease (in mother)	0.3	0.3	1.0	-0.2	-1.0
Sensitivity / hurt feelings	0.3	0.6	1.7	-1.3	0.1
Severe depression (siblings)	0.3	0.3	0.5	-0.7	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	-0.8	-0.7
Medication: Levothyroxine sodium	0.3	0.5	1.3	-0.3	-1.2
Number of incorrect matches in round	0.3	0.4	0.8	-0.7	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.3	1.5	0.2
Heart attack	0.3	0.4	1.2	0.1	-1.1
Time employed in main current job	0.3	0.3	0.9	-0.2	1.0
Worrier / anxious feelings	0.3	0.5	1.2	-0.6	1.1
Prospective memory result	0.3	0.4	0.6	-0.7	0.8
Medication: Amlodipine	0.3	0.4	1.1	0.5	-1.0
Birth weight	0.3	0.6	1.1	0.9	1.1
Forced vital capacity (FVC), Best measure	0.3	1.0	2.9	0.4	-1.7
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.9	-0.5
Number of full brothers	0.3	0.3	1.0	0.2	-1.0
Qualifications: College or University degree	0.3	0.9	2.8	0.0	1.7
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	-0.6	1.0
Migraine (self-reported)	0.3	0.3	0.9	-0.3	0.9
Leg pain on walking	0.3	0.4	0.9	-0.6	-0.9
Medication: Aspirin	0.3	0.4	0.8	0.9	-0.6
Average weekly red wine intake	0.3	0.5	1.5	-0.2	-1.2
Osteoarthritis (self-reported)	0.3	0.3	0.7	-0.6	-0.8
Medication: Aspirin	0.3	0.4	0.5	0.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.6	1.3	-0.7
Guilty feelings	0.3	0.4	1.0	-0.4	-1.0
Medication: Bendroflumethiazide	0.3	0.4	1.1	0.3	-1.1
Leg fat percentage (left)	0.3	1.1	2.2	1.0	-1.5
Fractured/broken bones in last 5 years	0.3	0.4	1.1	0.2	1.1
Mean Putamen Volume	0.2	0.3	0.6	-0.4	-0.8
Triglycerides	0.2	0.3	0.7	-0.8	0.3
Blood Platelet Count	0.2	2.4	4.5	-2.1	1.6
BMI	0.2	0.9	2.0	-1.4	0.9
Smoking Status	0.2	0.5	1.2	-0.5	-1.1
Hypothyroidism (self reported)	0.2	0.5	1.3	0.2	-1.1
Maternal smoking around birth	0.2	0.4	0.7	0.6	-0.8
Relative age voice broke	0.2	0.2	0.7	-0.1	0.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.6	-0.5
Qualifications: CSEs or equivalent	0.2	0.2	0.6	0.8	-0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	0.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	0.4	-0.9
Had other major operations	0.2	0.2	0.6	0.1	-0.8
Medication: Simvastatin	0.2	0.3	0.8	0.4	-0.9
Weight	0.2	1.1	1.7	-1.3	1.2
Alcohol intake versus 10 years previously	0.2	0.3	0.9	0.0	0.9
Number of live births	0.2	0.2	0.7	0.8	0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.7	0.3	-1.3
Medication: Lansoprazole	0.2	0.3	0.8	-0.9	-0.0
Breastfed as a baby	0.2	0.2	0.5	0.7	0.5
Peak expiratory flow (PEF)	0.2	0.4	0.6	-0.7	-0.8
Pulse wave reflection index	0.2	0.2	0.7	0.2	-0.8
Loud music exposure frequency	0.2	0.2	0.5	-0.5	0.7
Leg fat percentage (right)	0.2	0.8	1.6	0.9	-1.3
Age at first live birth	0.2	0.3	0.7	-0.4	0.8
Neck or shoulder pain in last month	0.2	0.2	0.7	0.9	0.1
Medication: Ibuprofen	0.2	0.2	0.5	-0.7	-0.4
Alcohol intake frequency.	0.2	0.4	1.3	-0.1	1.2
Number of full sisters	0.2	0.2	0.3	0.6	-0.6
Overall health rating	0.2	0.5	1.4	-0.2	-1.2
Loneliness, isolation	0.2	0.3	0.7	0.5	-0.8
Friendships satisfaction	0.2	0.2	0.5	-0.3	0.7
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.7	0.5
Irritability	0.2	0.3	0.9	0.1	0.9
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.8	-0.1
Unable to work because of sickness or disability	0.2	0.3	0.7	-0.3	-0.8
Cholesterol lowering medication	0.2	0.3	0.9	-0.2	-0.9
Supplements: Calcium	0.2	0.2	0.6	0.8	-0.3
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	-0.3	1.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	-0.6	0.7
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.7	0.0
Age at First Birth	0.1	0.1	0.2	-0.5	0.3
Lupus	0.1	0.1	0.2	0.5	0.2
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.5	0.6
Rheumatoid Arthritis	0.1	0.1	0.4	0.2	0.6
Ulcerative Colitis	0.1	0.2	0.5	-0.2	0.7
Allergy or Eczema	0.1	0.2	0.4	-0.3	0.6
Lung FEV1/FVC ratio	0.1	0.3	0.6	-0.4	-0.8
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.5	0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.4	0.3
Pack years adult smoking proportion	0.1	0.2	0.4	0.4	-0.6
Trunk fat percentage	0.1	0.3	0.5	0.7	-0.6
Age when periods started (menarche)	0.1	0.3	0.8	-0.9	-0.4
Body mass index (BMI)	0.1	0.5	1.0	-0.6	1.0
Waist circumference	0.1	0.5	1.0	-0.7	1.0
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.0	0.7
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	0.4	0.6
Forced vital capacity (FVC)	0.1	0.5	1.4	0.3	-1.2
Illnesses of siblings	0.1	0.2	0.6	-0.2	0.8
Arm fat percentage (right)	0.1	0.2	0.5	0.7	-0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.2	0.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	0.6	-0.6
Standing height	0.1	0.8	2.0	-1.4	0.6
Length of working week for main job	0.1	0.1	0.1	-0.4	0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.2	0.7
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.4	-0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.1	-0.5
Body fat percentage	0.1	0.5	0.8	0.8	-0.9
Comparative body size at age 10	0.1	0.3	0.8	0.1	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.0	0.4
Comparative height size at age 10	0.1	0.3	0.5	-0.7	0.7
Chest pain or discomfort	0.1	0.2	0.3	-0.6	-0.4
Had major operations	0.1	0.1	0.2	-0.2	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.6	-0.3
Arm fat percentage (left)	0.1	0.3	0.5	0.7	-0.6
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.1	-0.4
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.3	0.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.7	0.3
Osteoporosis (self-reported)	0.1	0.1	0.3	0.0	0.5
Financial situation satisfaction	0.1	0.1	0.3	-0.6	0.1
Alcohol drinker status: Never	0.1	0.1	0.4	0.1	0.6
Ever smoked	0.1	0.3	0.7	-0.8	-0.2
Number of operations (self-reported)	0.1	0.2	0.4	0.4	-0.6
Average weekly beer plus cider intake	0.1	0.1	0.3	-0.5	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.5	-0.4
Bipolar Disorder (2018)	0.0	0.0	0.1	-0.2	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.1	0.3	-0.3	0.5
Height	0.0	0.8	1.9	-1.4	0.7
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	0.1	0.0
Hair Pigment	0.0	0.6	1.4	-0.6	1.2
Tanning	0.0	0.0	0.1	-0.3	-0.3
Hand grip strength (right)	0.0	0.1	0.3	-0.5	-0.2
Townsend deprivation index at recruitment	0.0	0.0	0.1	-0.3	0.0
Taking other prescription medications	0.0	0.0	0.0	0.0	0.0
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.1	0.4
Trunk fat mass	0.0	0.0	0.0	-0.0	-0.1
Past tobacco smoking	0.0	0.1	0.2	0.2	0.4
Alcohol usually taken with meals	0.0	0.0	0.1	0.3	0.1
Financial difficulties in last 2 years	0.0	0.0	0.1	0.0	0.4
Mouth/teeth dental problems	0.0	0.0	0.0	-0.2	0.0
Hip circumference	0.0	0.2	0.6	-0.0	0.7
Medication: Cholesterol lowering	0.0	0.0	0.1	0.3	0.0
Arm fat mass (right)	0.0	0.1	0.3	-0.1	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.3	-0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.1	0.2
High blood pressure (siblings)	0.0	0.0	0.0	0.1	0.0
Whole body fat mass	0.0	0.0	0.0	-0.0	-0.1
Leg fat mass (right)	0.0	0.0	0.0	0.2	-0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.2	-0.3
Arm fat mass (left)	0.0	0.1	0.2	-0.0	0.5
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	-0.1	-0.1
Wears glasses or contact lenses	0.0	0.1	0.2	-0.4	-0.0
Medication: Atorvastatin	0.0	0.1	0.1	-0.4	-0.2
Risk taking	0.0	0.0	0.0	-0.2	-0.1
Leg fat mass (left)	0.0	0.0	0.0	0.1	-0.2

Hub : Genes

PLN

Models

Trait associations