Hub : Genes

PLN

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0893 0.0347 2.2e-03 0.047 NA 0.022 NA 0.029 1.3e-04 NA 7.5e-03 NA 0.00250
2 GTEx Brain Hippocampus 0.6047 0.1386 2.4e-05 0.009 NA 0.228 NA 0.059 1.9e-01 NA 4.6e-06 NA 0.01700
3 NTR Blood 0.0217 0.0096 5.5e-04 0.015 0.012 0.012 0.015 0.011 7.6e-06 5e-05 5.8e-05 7.5e-06 0.00011

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.0 0.0 0.1 -0.2 0.0 -0.3
Bipolar Disorder or Schizophrenia 0.1 0.3 0.9 -0.3 0.0 1.0
Depressed Affect (Nagel 2018) 0.5 1.1 3.2 -0.2 0.0 -1.8
Depression (Nagel 2018) 0.9 1.3 3.4 0.7 0.0 -1.8
Intelligence (Savage-Jansen 2018) 0.6 1.8 5.5 -0.2 0.0 2.3
Neuroticism (Nagel 2018) 0.5 1.2 3.5 -0.1 0.0 -1.9
Schizophrenia (2018) 0.4 0.8 2.2 -0.3 0.0 1.5
Schizophrenia vs Biploar Disorder 0.8 1.1 2.1 -1.4 0.0 1.1
Worry (Nagel 2018) 1.7 3.6 7.7 1.7 0.0 -2.8
Alzheimer’s Disease (in mother) 0.3 0.3 1.0 -0.2 0.0 -1.0
Alzheimer’s Disease (in father) 0.4 0.4 0.9 -1.0 0.0 0.5
Alzheimer’s Disease (including proxy) 0.6 0.9 2.6 -1.6 0.0 0.3
Crohns Disease (2017) 0.7 1.6 3.7 -1.9 0.0 1.0
Irritable Bowel Disease (IBD) 0.1 0.3 0.4 -0.6 0.0 0.7
Ulcerative Colitis (UC) 0.1 0.2 0.5 0.7 0.0 0.0
Major Depression (MDD) 0.9 1.2 3.3 -1.8 0.0 -0.4
Reaction Time 0.8 1.4 3.0 1.1 0.0 -1.7
Verbal and Numeric Reasoning (VNR) 1.2 2.9 7.0 -1.3 0.0 2.6
Breast Cancer 0.5 1.3 3.1 0.8 0.0 -1.8
Ovarian Cancer 0.4 0.5 1.6 -1.3 0.0 -0.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.1 0.1 0.2 -0.5 0.0 0.3
Bipolar Disorder (2011) 1.1 1.0 3.0 0.3 0.0 1.7
Body Mass Index (BMI) (2010) 1.5 2.0 3.7 -1.9 0.0 1.6
Coronary Artery Disease (CAD) 1.0 1.1 3.0 -1.7 0.0 -0.6
Crohns Disease (2012) 2.0 3.2 8.5 -2.9 0.0 1.1
Mean Putamen Volume 0.2 0.3 0.6 -0.4 0.0 -0.8
Fasting Glucose 0.5 0.7 1.8 -1.4 0.0 0.3
HbA1C 1.2 1.4 3.1 -1.0 0.0 1.8
HDL Cholesterol 0.4 0.7 1.6 -1.3 0.0 0.7
LDL Cholesterol 1.2 1.9 3.0 -1.7 0.0 1.6
Lupus 0.1 0.1 0.2 0.5 0.0 0.2
Neuroticism (2016) 0.5 0.8 1.4 1.2 0.0 -1.0
Primary Biliary Cirrhosis 0.1 0.2 0.3 -0.5 0.0 0.6
Rheumatoid Arthritis 0.1 0.1 0.4 0.2 0.0 0.6
Schizophrenia (2014) 0.4 0.9 1.9 -0.9 0.0 1.4
Triglycerides 0.2 0.3 0.7 -0.8 0.0 0.3
Type 2 Diabetes (T2D) (2012) 2.3 2.6 5.7 -1.4 0.0 2.4
Ulcerative Colitis 0.1 0.2 0.5 -0.2 0.0 0.7
Blood Eosinophil Count 0.6 4.9 9.7 -2.2 0.0 3.1
Blood Platelet Count 0.2 2.4 4.5 -2.1 0.0 1.6
Blood Red Count 0.0 0.1 0.3 -0.3 0.0 0.5
Blood White Count 1.1 7.8 15.6 -2.8 0.0 3.9
Heel T-Score 1.8 14.2 23.0 4.8 0.0 -4.4
BMI 0.2 0.9 2.0 -1.4 0.0 0.9
Height 0.0 0.8 1.9 -1.4 0.0 0.7
Waist Hip Ratio (WHR) 0.5 2.3 4.6 -1.5 0.0 2.1
Systolic Blood Pressure 2.7 13.5 33.7 5.8 0.0 -2.6
Smoking Status 0.2 0.5 1.2 -0.5 0.0 -1.1
Allergy or Eczema 0.1 0.2 0.4 -0.3 0.0 0.6
Cardiovascular Disease 1.1 3.6 6.6 2.6 0.0 -2.0
Hypothyroidism (self reported) 0.2 0.5 1.3 0.2 0.0 -1.1
Respiratory disease 1.2 2.7 4.8 -2.2 0.0 1.8
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.0 0.1 0.0 0.0
Lung FEV1/FVC ratio 0.1 0.3 0.6 -0.4 0.0 -0.8
Lung FVC 1.7 8.8 15.2 3.3 0.0 -3.9
Neuroticism 0.9 2.2 5.2 1.3 0.0 -2.3
Chronotype (morning person) 1.5 3.5 6.8 2.6 0.0 -1.9
Hair Pigment 0.0 0.6 1.4 -0.6 0.0 1.2
Tanning 0.0 0.0 0.1 -0.3 0.0 -0.3
Hand grip strength (left) 0.8 2.1 3.6 -1.9 0.0 1.7
Number of treatments/medications taken 0.6 1.1 3.2 1.8 0.0 0.0
Average weekly spirits intake 0.9 1.1 3.2 1.8 0.0 -0.2
Sensitivity / hurt feelings 0.3 0.6 1.7 -1.3 0.0 0.1
Frequency of depressed mood in last 2 weeks 1.7 2.4 5.6 1.3 0.0 -2.4
Hearing difficulty/problems: Yes 0.1 0.1 0.2 0.5 0.0 0.3
Relative age of first facial hair 0.5 1.0 2.1 -0.9 0.0 1.5
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 -0.4 0.0 0.3
Ever used hormone-replacement therapy (HRT) 1.7 2.1 6.4 2.5 0.0 -0.0
Ever had hysterectomy (womb removed) 0.7 0.7 1.8 0.6 0.0 1.4
Systolic blood pressure, automated reading 2.5 7.2 16.1 4.0 0.0 -2.3
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 5.3 -2.3 0.0 2.0
Angina 0.5 0.7 1.6 0.7 0.0 1.3
Medication for hormone replacement therapy 1.8 2.0 4.3 -1.3 0.0 2.1
Vitamin and mineral supplements 1.7 2.3 3.8 -1.7 0.0 2.0
Supplements: Zinc 0.6 0.7 2.0 0.0 0.0 -1.4
Medication: Co-codamol 0.4 0.4 1.0 1.0 0.0 -0.5
Medication: Metformin 0.6 0.9 1.7 -1.3 0.0 1.0
Diabetes (father) 0.5 0.6 1.1 -1.1 0.0 0.9
Diabetes (mother) 1.4 1.7 3.0 -1.5 0.0 1.7
Severe depression (siblings) 0.3 0.3 0.5 -0.7 0.0 -0.7
Pack years adult smoking proportion 0.1 0.2 0.4 0.4 0.0 -0.6
Impedance of leg (right) 0.9 4.6 8.1 2.4 0.0 -2.9
Leg fat-free mass (left) 0.8 4.3 6.9 -2.5 0.0 2.6
Trunk fat percentage 0.1 0.3 0.5 0.7 0.0 -0.6
Hand grip strength (right) 0.0 0.1 0.3 -0.5 0.0 -0.2
Townsend deprivation index at recruitment 0.0 0.0 0.1 -0.3 0.0 0.0
Current tobacco smoking 0.6 1.0 2.8 -1.7 0.0 -0.3
Average weekly fortified wine intake 4.0 4.6 8.7 2.3 0.0 -2.9
Maternal smoking around birth 0.2 0.4 0.7 0.6 0.0 -0.8
Fed-up feelings 1.1 2.1 5.1 1.1 0.0 -2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 3.5 1.1 0.0 -1.9
Relative age voice broke 0.2 0.2 0.7 -0.1 0.0 0.9
Taking other prescription medications 0.0 0.0 0.0 0.0 0.0 0.0
Age when periods started (menarche) 0.1 0.3 0.8 -0.9 0.0 -0.4
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 1.6 1.2 0.0 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 2.9 1.7 0.0 -0.5
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 -0.6 0.0 -0.5
Qualifications: CSEs or equivalent 0.2 0.2 0.6 0.8 0.0 -0.3
Serious illness, injury or assault to yourself 1.0 1.3 2.5 -1.6 0.0 1.2
High blood pressure 3.3 9.2 14.1 3.8 0.0 -3.7
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.2 -0.1 0.0 0.4
Multivitamins +/- minerals 1.1 1.4 3.6 0.7 0.0 -1.9
Stomach or abdominal pain in last month 1.1 1.3 2.5 -1.6 0.0 -1.2
Supplements: Glucosamine 3.2 4.1 7.0 2.7 0.0 -2.3
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.7 -0.8 0.0 -0.7
Medication: Atenolol 1.4 1.7 4.5 2.1 0.0 -0.9
Medication: Levothyroxine sodium 0.3 0.5 1.3 -0.3 0.0 -1.2
Sitting height 0.6 4.1 8.6 -2.9 0.0 1.9
Chronic bronchitis/emphysema (father) 0.2 0.2 0.7 0.2 0.0 -0.8
High blood pressure (mother) 1.9 2.7 6.3 2.5 0.0 -1.4
Body mass index (BMI) 0.1 0.5 1.0 -0.6 0.0 1.0
Impedance of leg (left) 1.2 5.8 10.7 2.6 0.0 -3.3
Leg predicted mass (left) 0.9 4.6 7.5 -2.5 0.0 2.7
Trunk fat mass 0.0 0.0 0.0 -0.0 0.0 -0.1
Waist circumference 0.1 0.5 1.0 -0.7 0.0 1.0
Number of incorrect matches in round 0.3 0.4 0.8 -0.7 0.0 0.9
Past tobacco smoking 0.0 0.1 0.2 0.2 0.0 0.4
Alcohol usually taken with meals 0.0 0.0 0.1 0.3 0.0 0.1
Nervous feelings 1.4 2.5 4.2 1.8 0.0 -2.0
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.9 0.4 0.0 -0.9
Hearing difficulty/problems with background noise 0.1 0.2 0.5 0.0 0.0 0.7
Hair/balding pattern: Pattern 2 0.1 0.2 0.4 0.4 0.0 0.6
Had menopause 0.9 1.2 2.6 1.6 0.0 -0.9
Had other major operations 0.2 0.2 0.6 0.1 0.0 -0.8
Forced vital capacity (FVC) 0.1 0.5 1.4 0.3 0.0 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.3 1.5 0.0 0.2
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 4.8 -2.2 0.0 1.1
Qualifications: None of the above 0.4 0.8 1.4 -1.2 0.0 -1.0
Financial difficulties in last 2 years 0.0 0.0 0.1 0.0 0.0 0.4
Mouth/teeth dental problems 0.0 0.0 0.0 -0.2 0.0 0.0
Heart attack 0.3 0.4 1.2 0.1 0.0 -1.1
Allergy 0.5 1.1 2.0 1.2 0.0 -1.4
Pain all over the body in last month 1.5 1.7 4.2 -0.9 0.0 2.0
Diabetes (self-reported) 0.5 0.7 2.1 -1.5 0.0 0.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.6 0.2 0.0 1.2
Medication: Ramipril 0.9 1.2 2.3 1.5 0.0 -1.1
Medication: Simvastatin 0.2 0.3 0.8 0.4 0.0 -0.9
Fluid intelligence score 2.5 5.1 9.9 -2.3 0.0 3.2
Illnesses of siblings 0.1 0.2 0.6 -0.2 0.0 0.8
Neuroticism score 0.9 1.8 5.0 0.7 0.0 -2.2
Weight 0.2 1.1 1.7 -1.3 0.0 1.2
Impedance of arm (right) 0.8 3.9 9.2 1.6 0.0 -3.0
Arm fat percentage (right) 0.1 0.2 0.5 0.7 0.0 -0.4
Trunk fat-free mass 0.7 4.3 7.1 -2.4 0.0 2.7
Hip circumference 0.0 0.2 0.6 -0.0 0.0 0.7
Time employed in main current job 0.3 0.3 0.9 -0.2 0.0 1.0
Alcohol intake versus 10 years previously 0.2 0.3 0.9 0.0 0.0 0.9
Father’s age at death 0.8 1.1 2.5 0.9 0.0 -1.6
Worrier / anxious feelings 0.3 0.5 1.2 -0.6 0.0 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 2.2 0.8 0.0 -1.5
Falls in the last year 0.5 0.6 1.8 -1.3 0.0 0.3
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 0.2 0.0 0.6
Number of live births 0.2 0.2 0.7 0.8 0.0 0.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.7 0.3 0.0 -1.3
Pulse rate 4.5 7.6 18.7 2.1 0.0 -4.3
Happiness 0.6 0.7 2.0 -0.4 0.0 -1.4
Noisy workplace 0.4 0.5 1.3 1.2 0.0 0.1
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.7 -1.3 0.0 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 1.7 -1.3 0.0 1.2
Mouth/teeth dental problems: Dentures 0.1 0.2 0.4 0.6 0.0 -0.6
Asthma 1.3 2.6 5.3 -2.3 0.0 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.5 -1.2 0.0 -0.2
Medication: Cholesterol lowering 0.0 0.0 0.1 0.3 0.0 0.0
Depression (self-reported) 1.3 1.5 2.5 1.5 0.0 -1.6
Medication: Lansoprazole 0.2 0.3 0.8 -0.9 0.0 -0.0
Prospective memory result 0.3 0.4 0.6 -0.7 0.0 0.8
Lung cancer (father) 1.1 1.3 2.8 -1.1 0.0 1.7
Illnesses of mother 1.1 1.4 4.1 -2.0 0.0 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 3.5 0.4 0.0 -1.9
Pulse wave Arterial Stiffness index 0.8 1.0 1.6 -1.3 0.0 -1.1
Impedance of arm (left) 1.0 4.8 11.4 1.8 0.0 -3.4
Arm fat mass (right) 0.0 0.1 0.3 -0.1 0.0 0.6
Trunk predicted mass 0.7 4.3 7.1 -2.4 0.0 2.7
Standing height 0.1 0.8 2.0 -1.4 0.0 0.6
Length of working week for main job 0.1 0.1 0.1 -0.4 0.0 0.4
Exposure to tobacco smoke at home 0.5 0.6 1.6 1.3 0.0 -0.3
Breastfed as a baby 0.2 0.2 0.5 0.7 0.0 0.5
Tense / ‘highly strung’ 3.8 6.2 12.8 2.4 0.0 -3.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.1 -0.3 0.0 -0.1
Hair/balding pattern: Pattern 4 0.5 1.1 2.5 -1.6 0.0 -0.9
Birth weight of first child 0.5 1.0 2.1 -0.9 0.0 1.5
Peak expiratory flow (PEF) 0.2 0.4 0.6 -0.7 0.0 -0.8
Pulse wave reflection index 0.2 0.2 0.7 0.2 0.0 -0.8
Ever highly irritable/argumentative for 2 days 0.7 0.9 2.1 0.7 0.0 -1.4
Loud music exposure frequency 0.2 0.2 0.5 -0.5 0.0 0.7
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.5 0.2 0.0 0.7
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.9 0.8 0.0 -1.4
Blood clot in the leg (DVT) 0.1 0.1 0.2 0.4 0.0 -0.3
Medication: Paracetamol 0.4 0.7 2.0 1.4 0.0 -0.0
Headache pain in last month 0.8 1.4 2.5 1.6 0.0 -1.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.6 -1.0 0.0 1.2
Glaucoma (self-reported) 0.9 1.1 3.1 -0.2 0.0 -1.8
Gout (self-reported) 1.8 2.5 6.2 1.2 0.0 -2.5
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.0 -0.1 0.0 -0.1
Medication: Amlodipine 0.3 0.4 1.1 0.5 0.0 -1.0
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 0.1 0.0 -0.5
Birth weight 0.3 0.6 1.1 0.9 0.0 1.1
Chronic bronchitis/emphysema (mother) 0.0 0.0 0.0 0.1 0.0 0.2
High blood pressure (siblings) 0.0 0.0 0.0 0.1 0.0 0.0
Forced vital capacity (FVC), Best measure 0.3 1.0 2.9 0.4 0.0 -1.7
Body fat percentage 0.1 0.5 0.8 0.8 0.0 -0.9
Leg fat percentage (right) 0.2 0.8 1.6 0.9 0.0 -1.3
Arm fat-free mass (right) 0.6 3.2 6.1 -1.9 0.0 2.5
Exposure to tobacco smoke outside home 0.3 0.4 0.9 0.9 0.0 -0.5
Comparative body size at age 10 0.1 0.3 0.8 0.1 0.0 -0.9
Number of full brothers 0.3 0.3 1.0 0.2 0.0 -1.0
Worry too long after embarrassment 0.4 0.7 1.8 -0.6 0.0 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 2.2 1.5 0.0 1.0
Wheeze or whistling in the chest in last year 0.6 1.1 2.2 -1.0 0.0 1.5
Number of children fathered 0.4 0.4 0.7 0.7 0.0 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 4.2 -2.1 0.0 1.5
Age at first live birth 0.2 0.3 0.7 -0.4 0.0 0.8
Pulse wave peak to peak time 1.0 1.2 2.4 1.1 0.0 1.6
Health satisfaction 1.4 1.8 2.8 -1.6 0.0 -1.7
Shortness of breath walking on level ground 0.9 1.1 2.6 -1.6 0.0 -0.9
Qualifications: College or University degree 0.3 0.9 2.8 0.0 0.0 1.7
Eye problems/disorders: None of the above 0.8 0.9 1.9 1.4 0.0 -0.9
Mouth/teeth dental problems: Loose teeth 1.3 1.6 3.1 1.3 0.0 1.8
Emphysema/chronic bronchitis 0.8 0.9 2.3 -0.7 0.0 1.5
Medication for pain relief, constipation, heartburn 0.3 0.5 1.0 -0.6 0.0 1.0
Neck or shoulder pain in last month 0.2 0.2 0.7 0.9 0.0 0.1
Medication: Blood pressure 0.8 1.3 2.9 1.7 0.0 -1.0
Angina (self-reported) 0.6 0.8 1.9 0.6 0.0 1.4
Migraine (self-reported) 0.3 0.3 0.9 -0.3 0.0 0.9
Medication: Ibuprofen 0.2 0.2 0.5 -0.7 0.0 -0.4
Medication: Allopurinol 0.9 1.2 3.4 0.5 0.0 -1.8
Medication: Omeprazole 0.9 1.1 3.2 1.8 0.0 -0.2
Medication: Seretide 50 evohaler 1.0 1.1 2.1 -1.5 0.0 1.1
Mean time to correctly identify matches 0.8 1.6 3.6 1.1 0.0 -1.9
Heart disease (mother) 0.7 0.8 2.0 -0.7 0.0 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 0.0 0.0 0.4
Whole body fat mass 0.0 0.0 0.0 -0.0 0.0 -0.1
Leg fat mass (right) 0.0 0.0 0.0 0.2 0.0 -0.1
Arm predicted mass (right) 0.6 2.9 5.1 -1.9 0.0 2.3
Pulse rate, automated reading 9.2 29.8 78.0 3.4 0.0 -8.8
Alcohol intake frequency. 0.2 0.4 1.3 -0.1 0.0 1.2
Comparative height size at age 10 0.1 0.3 0.5 -0.7 0.0 0.7
Number of full sisters 0.2 0.2 0.3 0.6 0.0 -0.6
Suffer from ‘nerves’ 3.9 6.2 18.1 0.7 0.0 -4.2
Overall health rating 0.2 0.5 1.4 -0.2 0.0 -1.2
Chest pain or discomfort 0.1 0.2 0.3 -0.6 0.0 -0.4
Had major operations 0.1 0.1 0.2 -0.2 0.0 -0.5
Age at last live birth 0.5 0.7 1.3 -0.8 0.0 1.1
Family relationship satisfaction 0.6 0.8 2.0 0.6 0.0 -1.4
Leg pain on walking 0.3 0.4 0.9 -0.6 0.0 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.4 -0.6 0.0 -0.3
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.2 1.5 0.0 1.1
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.1 0.2 0.0 -0.3
Medication: Aspirin 0.3 0.4 0.8 0.9 0.0 -0.6
Supplements: Vitamin C 1.3 1.6 3.7 1.9 0.0 -1.0
Knee pain experienced in last month 0.6 0.9 2.3 -0.7 0.0 -1.5
Hypertension (Self-reported) 3.1 8.5 13.0 3.6 0.0 -3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.8 -0.9 0.0 -0.8
Illnesses of father: Heart disease 2.0 2.8 5.4 1.7 0.0 -2.3
Illnesses of siblings: Diabetes 0.5 0.6 1.3 -1.1 0.0 0.8
Smoking status: Previous 0.6 0.9 2.1 0.8 0.0 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 5.1 -1.4 0.0 2.3
Whole body fat-free mass 0.8 4.7 7.8 -2.5 0.0 2.8
Leg fat-free mass (right) 0.8 4.3 6.9 -2.5 0.0 2.6
Arm fat percentage (left) 0.1 0.3 0.5 0.7 0.0 -0.6
Average weekly red wine intake 0.3 0.5 1.5 -0.2 0.0 -1.2
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.4 0.0 -0.3
Mood swings 0.8 1.4 4.2 0.3 0.0 -2.0
Loneliness, isolation 0.2 0.3 0.7 0.5 0.0 -0.8
Long-standing illness, disability or infirmity 0.6 1.0 2.9 -0.1 0.0 -1.7
Ever had bowel cancer screening 0.6 0.7 2.1 -1.4 0.0 0.2
Diabetes diagnosed by doctor 0.4 0.6 1.9 -1.4 0.0 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.1 -0.1 0.0 -0.4
Friendships satisfaction 0.2 0.2 0.5 -0.3 0.0 0.7
Qualifications: nursing, teaching 0.1 0.2 0.4 -0.3 0.0 0.7
Commuting to job workplace: Walk 0.2 0.2 0.5 -0.7 0.0 0.5
Eye problems/disorders: Cataract 2.7 3.1 5.5 -1.9 0.0 2.3
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 0.7 0.0 0.3
Medication for cholesterol 0.6 0.9 2.4 -1.5 0.0 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.6 -1.3 0.0 0.8
Back pain experienced in last month 1.0 1.5 3.6 0.9 0.0 -1.9
Mineral and other dietary supplements 0.7 1.0 2.4 -1.5 0.0 0.8
Breast cancer (self-reported) 1.1 1.4 3.6 -0.7 0.0 1.9
Asthma (self-reported) 0.9 1.8 3.7 -1.9 0.0 1.3
Osteoporosis (self-reported) 0.1 0.1 0.3 0.0 0.0 0.5
Osteoarthritis (self-reported) 0.3 0.3 0.7 -0.6 0.0 -0.8
Medication: Aspirin 0.3 0.4 0.5 0.7 0.0 -0.7
Medication: Gliclazide 0.8 0.9 2.4 -1.6 0.0 -0.3
Illnesses of father: None of the above (group 1) 2.7 3.4 6.1 -2.0 0.0 2.5
Smoking status: Current 0.7 1.1 3.2 -1.8 0.0 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.6 1.3 0.0 -0.7
Whole body water mass 0.8 4.6 7.8 -2.5 0.0 2.8
Leg predicted mass (right) 0.9 4.6 7.4 -2.5 0.0 2.7
Arm fat mass (left) 0.0 0.1 0.2 -0.0 0.0 0.5
Number of self-reported non-cancer illnesses 0.0 0.0 0.0 -0.1 0.0 -0.1
Average weekly champagne plus white wine intake 0.4 0.6 1.8 -0.1 0.0 -1.3
Miserableness 1.6 2.8 6.8 1.3 0.0 -2.6
Guilty feelings 0.3 0.4 1.0 -0.4 0.0 -1.0
Wears glasses or contact lenses 0.0 0.1 0.2 -0.4 0.0 -0.0
Ever taken oral contraceptive pill 3.7 4.1 8.0 -2.1 0.0 2.8
Hearing aid user 0.7 0.8 2.1 0.4 0.0 1.5
Mother’s age at death 0.4 0.5 1.4 1.2 0.0 0.0
Financial situation satisfaction 0.1 0.1 0.3 -0.6 0.0 0.1
Tinnitus: Yes, now most or all of the time 1.0 1.2 3.3 1.8 0.0 0.4
Commuting to job workplace: Public transport 0.5 0.6 1.7 -0.4 0.0 -1.3
Eye problems/disorders: Glaucoma 0.6 0.7 2.2 -0.1 0.0 -1.5
Medication: Blood pressure 2.4 4.7 8.9 3.0 0.0 -2.3
Pain type(s) experienced in last month: Hip pain 2.2 2.8 6.8 1.3 0.0 -2.6
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.2 0.7 0.0 1.1
High cholesterol (Self-reported) 0.7 1.2 3.0 1.7 0.0 -0.8
Medication: Bendroflumethiazide 0.3 0.4 1.1 0.3 0.0 -1.1
Medication: Paracetamol 0.6 1.0 3.0 1.7 0.0 0.1
Medication: Lisinopril 1.7 2.2 4.3 2.1 0.0 -1.5
Medication: Atorvastatin 0.0 0.1 0.1 -0.4 0.0 -0.2
Illnesses of father: High blood pressure 0.9 1.1 2.0 1.2 0.0 -1.4
Alcohol drinker status: Never 0.1 0.1 0.4 0.1 0.0 0.6
Ever smoked 0.1 0.3 0.7 -0.8 0.0 -0.2
Basal metabolic rate 0.7 3.7 6.2 -2.2 0.0 2.5
Leg fat percentage (left) 0.3 1.1 2.2 1.0 0.0 -1.5
Arm fat-free mass (left) 0.6 2.9 5.9 -1.7 0.0 2.4
Number of operations (self-reported) 0.1 0.2 0.4 0.4 0.0 -0.6
Average weekly beer plus cider intake 0.1 0.1 0.3 -0.5 0.0 0.4
Irritability 0.2 0.3 0.9 0.1 0.0 0.9
Risk taking 0.0 0.0 0.0 -0.2 0.0 -0.1
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 -0.8 0.0 -0.1
Fractured/broken bones in last 5 years 0.3 0.4 1.1 0.2 0.0 1.1
Age started oral contraceptive pill 1.0 1.2 3.4 1.8 0.0 -0.4
Diastolic blood pressure, automated reading 4.8 14.9 30.1 3.8 0.0 -5.5
Ever depressed for a whole week 0.5 0.6 1.6 -1.3 0.0 0.4
Unable to work because of sickness or disability 0.2 0.3 0.7 -0.3 0.0 -0.8
Commuting to job workplace: Cycle 1.1 1.4 2.4 -1.5 0.0 1.3
Myopia 0.6 0.9 2.8 -1.7 0.0 -0.1
Vascular/heart problems diagnosed by doctor 2.9 8.0 12.8 -3.6 0.0 3.3
Cholesterol lowering medication 0.2 0.3 0.9 -0.2 0.0 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.4 1.5 0.0 -1.0
Pain experienced in last month 0.8 1.3 2.7 -1.6 0.0 1.1
Supplements: Calcium 0.2 0.2 0.6 0.8 0.0 -0.3
Basal cell carcinoma (self-reported) 0.4 0.5 1.5 1.2 0.0 -0.1
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.4 0.2 0.0 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.3 0.5 0.0 -0.4
Heart disease (siblings) 0.4 0.5 1.5 0.1 0.0 -1.2
Alcohol drinker status: Previous 0.7 0.8 1.9 -1.4 0.0 -0.8
Pack years of smoking 0.4 0.6 1.5 0.4 0.0 -1.2
Impedance of whole body 1.1 5.8 12.0 2.3 0.0 -3.5
Leg fat mass (left) 0.0 0.0 0.0 0.1 0.0 -0.2
Arm predicted mass (left) 0.7 3.4 7.0 -1.8 0.0 2.6