Hub : Genes

PLXDC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1220	0.0320	5.9e-08	0.107	0.061	0.070	0.060	0.040	5.8e-13	6.8e-08	6.9e-09	8.3e-08	9.9e-06
2	GTEx	Skin Sun Exposed Lower leg	0.1710	0.0540	1.5e-04	0.095	NA	0.069	NA	0.075	2.7e-08	NA	2.1e-06	NA	7.9e-07
3	GTEx	Spleen	0.4340	0.1190	4.3e-03	0.046	NA	0.115	NA	0.084	2.6e-02	NA	7.0e-04	NA	3.6e-03
4	GTEx	Whole Blood	0.2120	0.0430	5.2e-12	0.159	NA	0.187	NA	0.183	1.6e-14	NA	5.5e-17	NA	1.1e-16
5	NTR	Blood	0.0291	0.0122	1.4e-03	0.000	0.009	0.016	0.012	0.005	3.3e-01	3.6e-04	4.4e-06	5.8e-05	6.3e-03
6	YFS	Blood	0.0271	0.0094	6.7e-05	0.025	0.016	0.018	0.016	0.020	1.2e-08	3.1e-06	1.4e-06	5.3e-06	2.9e-07
7	TCGA	Prostate Adenocarcinoma	0.0446	0.0246	7.8e-03	0.006	0.014	0.000	NA	0.003	6.9e-02	1.1e-02	3.0e-01	NA	1.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.5	2.4	6.6	-2.6	-2.0	0.8	2.0	-0.8	-0.9	-0.5
Bipolar Disorder or Schizophrenia	1.2	2.9	6.7	-2.6	-2.4	1.4	0.8	-1.2	-2.0	0.0
Depressed Affect (Nagel 2018)	1.1	2.3	6.8	2.6	2.1	0.4	-1.3	0.3	0.3	1.8
Depression (Nagel 2018)	1.2	1.7	4.7	2.2	1.8	-0.8	-1.9	0.1	0.2	-0.1
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.0	-1.7	-2.2	2.0	1.1	0.2	-1.3	-0.5
Neuroticism (Nagel 2018)	1.1	2.5	7.7	2.8	2.4	0.4	-1.3	0.3	0.6	1.4
Schizophrenia (2018)	0.6	1.3	3.3	-1.2	-1.5	1.0	-0.6	-0.8	-1.8	0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	-0.8	-1.0	0.1	0.9	0.6	-0.7	-0.5
Worry (Nagel 2018)	1.3	2.7	8.6	2.9	2.4	0.8	-1.9	0.4	0.6	0.5
Alzheimer’s Disease (in mother)	1.5	1.8	2.8	-1.3	-1.4	1.6	1.7	0.7	0.4	-1.6
Alzheimer’s Disease (in father)	1.0	1.1	2.4	-1.6	-1.3	-0.1	1.5	0.2	0.3	-0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	3.1	-0.7	-0.6	1.5	1.8	1.4	1.2	-1.4
Crohns Disease (2017)	0.3	0.6	1.2	0.3	-0.9	0.6	-0.6	-0.7	-0.9	1.1
Irritable Bowel Disease (IBD)	0.4	0.9	2.7	1.3	0.1	-0.2	-1.2	-0.7	-0.4	1.6
Ulcerative Colitis (UC)	0.6	1.1	2.0	1.3	0.7	-1.1	-1.3	-0.8	0.1	1.4
Major Depression (MDD)	0.6	0.7	1.4	-1.0	-1.1	-0.3	1.0	-0.3	-0.2	-1.2
Reaction Time	0.4	0.8	2.2	-0.8	-0.3	-0.5	0.9	-0.1	1.2	-1.5
Verbal and Numeric Reasoning (VNR)	1.1	2.7	6.5	-2.5	-2.4	-0.1	1.1	-1.1	-2.0	-0.4
Breast Cancer	0.1	0.1	0.4	0.2	-0.6	0.2	-0.2	-0.6	0.1	-0.0
Ovarian Cancer	2.7	3.5	8.4	-2.9	-1.8	-1.2	1.9	-1.5	-0.6	-2.3
Prostate Cancer	1.1	1.5	4.8	-1.9	-1.0	-0.3	0.6	-0.8	-0.7	-2.2
Age at First Birth	1.8	2.6	8.1	-0.2	-1.4	2.8	1.5	1.5	1.0	-1.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	2.0	0.5	1.1	-1.4	-0.1	-0.2	0.9	-1.4
Coronary Artery Disease (CAD)	0.5	0.5	2.3	0.9	0.4	-0.2	-1.5	-0.6	0.3	0.0
Crohns Disease (2012)	1.4	2.3	4.8	0.1	-0.7	-1.8	-1.6	-2.2	-1.6	1.6
Mean Putamen Volume	1.3	1.5	6.4	0.4	1.1	-2.5	-0.0	-0.3	0.8	-1.5
Fasting Glucose	1.4	1.6	4.0	-1.8	-1.9	0.7	2.0	-0.1	0.3	0.2
HbA1C	0.9	1.0	3.5	-1.1	-0.6	0.1	1.9	0.9	1.0	-0.5
HDL Cholesterol	1.3	2.1	6.4	-1.2	-2.5	1.5	1.8	-0.4	-1.2	0.0
LDL Cholesterol	1.0	1.6	3.9	-1.7	-2.0	0.1	0.2	-1.1	-1.6	-0.5
Lupus	2.6	4.0	10.2	-1.9	-3.2	2.4	1.3	-0.2	-2.4	-0.7
Neuroticism (2016)	1.0	1.4	3.8	1.6	1.9	-1.1	-0.6	-0.3	1.2	0.5
Primary Biliary Cirrhosis	0.5	0.7	2.9	1.7	1.1	0.1	-0.8	-0.0	-0.2	-0.6
Rheumatoid Arthritis	0.9	1.2	3.3	0.9	0.3	1.3	0.1	1.8	0.4	-1.6
Schizophrenia (2014)	1.0	2.2	4.2	-2.0	-2.1	1.4	0.2	-0.7	-2.0	-0.2
Triglycerides	0.1	0.2	0.5	0.2	0.6	0.0	-0.7	-0.0	-0.1	-0.4
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.6	0.5	1.5	-1.4	-1.5	-0.5	-0.4	1.9
Ulcerative Colitis	0.5	0.7	1.7	0.5	-0.3	-1.3	-0.2	-0.8	-0.6	1.3
Blood Eosinophil Count	0.5	4.2	9.9	-3.1	-2.5	3.1	1.0	-1.2	-0.9	-0.3
Blood Platelet Count	0.5	5.3	14.7	-2.3	-3.1	0.9	1.8	1.3	-1.3	-3.8
Blood Red Count	1.4	13.3	44.5	-4.8	-0.7	-6.7	-0.1	-4.3	-2.6	-0.2
Blood White Count	1.5	11.0	22.2	-4.7	-3.5	4.7	3.5	2.5	-1.0	0.3
Heel T-Score	0.3	2.4	8.1	-0.9	-0.8	-1.7	0.3	-1.7	1.1	-2.8
BMI	0.4	2.4	5.1	-0.4	0.6	-2.1	-1.0	-2.3	-1.4	1.9
Height	0.2	4.4	11.8	1.7	-1.2	3.4	1.7	2.9	1.8	0.5
Waist Hip Ratio (WHR)	0.2	0.8	3.1	0.1	-0.0	-0.5	-1.2	-0.5	-1.8	0.7
Systolic Blood Pressure	0.2	1.0	1.7	1.0	1.3	-0.9	-0.3	1.1	0.9	-1.1
Smoking Status	0.6	1.4	4.3	-2.1	-1.3	-0.4	1.0	-0.4	-0.5	-1.5
Allergy or Eczema	0.2	0.6	1.4	-1.2	-0.4	0.6	-0.4	-0.8	-0.9	0.8
Cardiovascular Disease	0.3	0.8	3.0	0.4	0.9	-1.7	-1.0	-0.0	-0.6	0.8
Hypothyroidism (self reported)	0.8	1.8	7.4	-1.1	-1.6	2.7	0.8	0.5	-0.6	-0.4
Respiratory disease	0.5	1.1	5.0	-2.2	-0.4	0.7	0.7	0.4	-0.7	0.8
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.2	-1.1	-0.4	-0.6	0.3	0.4	-0.7	1.0
Lung FEV1/FVC ratio	0.2	1.2	3.0	0.2	0.5	-1.6	-0.7	-1.4	0.2	-1.7
Lung FVC	0.3	1.6	5.7	1.8	-0.8	2.4	-0.8	0.3	-0.8	0.3
Neuroticism	1.0	2.3	6.1	2.5	2.5	0.1	-1.5	0.1	0.7	1.0
Chronotype (morning person)	1.2	2.9	7.4	2.7	1.6	2.0	-1.3	1.5	0.9	1.3
Hair Pigment	0.0	1.0	2.3	0.5	-0.5	1.5	-0.5	-0.8	-1.2	1.2
Tanning	0.0	0.3	1.5	0.2	-0.1	1.2	-0.0	0.3	-0.2	0.6
Hand grip strength (left)	0.1	0.3	1.1	-0.6	-0.7	0.2	1.0	0.1	-0.1	-0.1
Number of treatments/medications taken	0.8	1.4	5.1	1.3	1.1	-0.1	0.0	2.2	1.3	0.5
Average weekly spirits intake	0.2	0.2	0.3	-0.3	-0.5	-0.1	0.6	-0.5	-0.5	-0.5
Sensitivity / hurt feelings	1.0	1.6	4.6	1.6	2.1	0.1	-1.0	0.8	0.8	1.5
Frequency of depressed mood in last 2 weeks	2.7	3.8	12.8	1.7	1.4	-0.4	-3.6	-1.4	-1.8	1.8
Hearing difficulty/problems: Yes	0.7	1.1	3.1	1.0	1.0	1.0	-0.0	1.8	1.0	0.9
Relative age of first facial hair	0.2	0.5	1.0	-0.4	-1.0	0.6	0.9	-0.3	-0.9	0.5
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	5.3	2.3	1.7	1.6	-1.1	1.1	1.5	0.5
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.4	1.5	1.3	1.4	-0.4	1.5	0.9	-0.0
Ever had hysterectomy (womb removed)	0.4	0.5	1.7	0.7	1.3	0.5	-0.7	0.3	0.6	-0.2
Systolic blood pressure, automated reading	0.2	0.7	2.9	0.0	0.6	-0.2	0.5	0.7	0.9	-1.7
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.9	1.4	1.7	-1.5	-1.4	-0.7	0.7	-0.8
Angina	1.2	1.6	6.7	0.8	0.6	-0.9	0.8	2.6	1.4	0.1
Medication for hormone replacement therapy	1.0	1.1	4.1	-0.6	-0.1	0.8	1.7	2.0	0.2	0.2
Vitamin and mineral supplements	0.6	0.8	3.3	0.5	1.1	-1.8	-0.3	-0.3	0.2	-0.6
Supplements: Zinc	1.0	1.1	3.6	0.9	0.0	0.2	-1.9	-1.2	-1.3	0.3
Medication: Co-codamol	2.0	2.3	5.5	0.1	0.3	-1.5	-1.8	-1.9	-2.3	1.0
Medication: Metformin	0.6	0.8	1.8	-1.1	-0.4	-0.4	1.3	0.8	-0.4	1.2
Diabetes (father)	2.0	2.5	9.3	-0.9	-1.7	3.0	0.5	-0.1	-1.6	1.2
Diabetes (mother)	0.5	0.6	2.6	0.5	0.5	-1.6	-0.5	-0.9	-0.1	0.0
Severe depression (siblings)	0.6	0.7	2.2	-1.0	-0.2	0.0	1.5	1.0	0.1	-0.6
Pack years adult smoking proportion	1.2	1.9	10.8	-0.0	-0.1	-3.3	-0.3	-0.4	-0.9	1.2
Impedance of leg (right)	0.6	3.0	11.0	1.3	1.7	0.7	1.0	1.9	3.3	-0.7
Leg fat-free mass (left)	0.2	1.2	2.8	-0.5	-1.2	-0.4	-0.3	-1.7	-1.7	1.0
Trunk fat percentage	0.8	3.2	8.2	1.4	2.5	-2.9	-0.5	0.4	1.7	1.5
Hand grip strength (right)	0.1	0.3	0.6	-0.7	-0.7	0.6	0.6	-0.0	-0.4	0.5
Townsend deprivation index at recruitment	0.3	0.5	1.6	-0.9	0.4	-1.3	0.2	-0.7	0.1	-0.4
Current tobacco smoking	1.2	2.0	5.0	-2.2	-1.9	-0.7	0.7	-1.1	-1.3	-1.4
Average weekly fortified wine intake	0.8	1.0	2.2	1.3	0.6	-0.2	-0.2	1.4	1.5	-0.8
Maternal smoking around birth	1.5	2.2	5.8	-1.1	-1.2	-2.4	0.4	-0.9	-1.9	1.6
Fed-up feelings	1.0	1.7	3.3	1.3	1.6	-0.0	-1.8	-0.8	-1.0	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.0	1.6	1.7	-1.4	-1.6	-0.5	-0.0	-0.4
Relative age voice broke	0.3	0.4	1.1	0.1	-0.5	1.1	0.9	-0.0	0.1	0.9
Taking other prescription medications	0.9	1.3	6.6	0.6	0.9	0.8	0.1	2.6	0.6	0.8
Age when periods started (menarche)	0.4	0.9	2.0	1.0	-0.1	-0.5	0.8	1.4	0.9	-1.2
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	4.0	1.7	2.0	0.5	-1.1	0.4	0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	9.4	-1.1	-1.6	0.3	2.0	0.5	1.5	-3.1
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	7.0	1.7	0.5	1.6	-2.6	-1.3	-1.7	1.8
Qualifications: CSEs or equivalent	3.7	4.9	9.8	1.3	1.6	-0.2	-3.1	-3.1	-2.1	2.4
Serious illness, injury or assault to yourself	0.9	1.1	2.7	1.6	0.7	0.5	-1.5	0.1	-0.2	1.3
High blood pressure	0.4	1.0	2.1	0.9	1.0	-0.9	-1.3	0.1	-1.0	1.4
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.2	-1.4	-0.8	-0.2	-0.9	-1.4	-1.8	1.4
Multivitamins +/- minerals	2.3	3.0	7.0	-1.7	-2.6	2.6	1.0	0.2	-1.4	0.9
Stomach or abdominal pain in last month	3.4	4.2	10.5	1.2	1.7	-3.2	-2.5	-2.5	-0.9	1.1
Supplements: Glucosamine	2.8	3.6	8.8	3.0	2.6	1.0	-2.8	-0.5	0.8	0.6
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	6.5	0.2	1.4	0.8	1.2	2.6	2.4	-1.7
Medication: Atenolol	0.5	0.6	1.9	-0.0	-0.4	-0.1	-1.1	-0.7	-1.4	0.5
Medication: Levothyroxine sodium	0.8	1.3	6.0	0.3	-0.9	2.5	-0.1	1.4	-0.1	0.3
Sitting height	0.1	0.9	2.6	-0.4	-1.4	1.0	1.6	0.4	0.3	-0.4
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	0.3	0.2	-0.8	0.0	0.5	0.4	0.0
High blood pressure (mother)	0.3	0.5	1.1	0.8	1.0	0.7	-0.6	-0.0	0.8	0.1
Body mass index (BMI)	0.6	2.5	7.3	-0.1	1.1	-2.7	-1.1	-1.4	-1.1	2.2
Impedance of leg (left)	0.6	2.8	9.9	1.3	2.1	0.1	0.5	1.6	3.1	-0.9
Leg predicted mass (left)	0.2	1.2	2.9	-0.5	-1.2	-0.4	-0.3	-1.6	-1.7	1.0
Trunk fat mass	0.5	2.3	8.1	1.1	1.9	-2.8	-0.6	-0.2	1.0	1.4
Waist circumference	0.3	1.1	3.2	0.1	0.8	-1.8	-0.9	-0.9	-0.7	1.3
Number of incorrect matches in round	0.5	0.8	2.5	-0.7	0.2	1.6	0.3	0.5	1.0	-1.0
Past tobacco smoking	0.4	0.7	2.3	1.5	0.6	0.7	-0.2	0.3	1.2	-0.0
Alcohol usually taken with meals	0.7	1.1	4.3	0.7	0.8	2.1	0.1	1.0	1.0	0.3
Nervous feelings	1.6	3.0	8.5	2.9	2.1	1.9	-1.7	0.7	0.9	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.2	0.8	0.4	-0.1	-1.4	-0.4	-1.5	0.6
Hearing difficulty/problems with background noise	1.3	2.0	6.0	0.1	0.1	2.1	1.6	2.5	1.0	0.4
Hair/balding pattern: Pattern 2	0.4	0.6	1.6	-0.6	-0.6	0.8	1.3	0.6	0.4	-0.6
Had menopause	0.2	0.3	0.8	0.5	0.6	0.4	-0.2	-0.2	0.4	0.9
Had other major operations	1.0	1.2	4.6	-1.4	-1.2	-0.2	0.3	0.1	-2.2	0.7
Forced vital capacity (FVC)	0.3	1.2	5.9	0.8	-0.7	2.4	-0.7	-0.7	-0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.3	-1.2	-1.8	0.2	1.4	0.1	0.1	-2.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.7	0.4	-0.0	0.7	-1.0	-1.4	-1.3	1.6
Qualifications: None of the above	0.4	0.9	2.7	0.9	1.2	-1.6	-0.4	0.8	0.9	-0.2
Financial difficulties in last 2 years	0.3	0.4	0.9	0.6	1.0	-0.7	-0.6	-0.3	0.2	0.5
Mouth/teeth dental problems	0.4	0.6	2.3	-0.4	-0.4	1.5	0.2	-0.7	-0.2	1.0
Heart attack	0.4	0.5	2.1	0.2	0.1	-1.5	0.6	0.6	0.7	0.2
Allergy	1.0	2.2	5.3	2.2	1.0	0.4	0.7	1.4	2.3	-1.4
Pain all over the body in last month	1.0	1.1	2.7	1.5	1.7	-0.8	-1.0	0.2	1.0	0.4
Diabetes (self-reported)	0.3	0.5	2.7	0.3	0.3	-0.8	-0.3	-0.1	-0.3	1.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.1	-0.5	-0.5	0.8	-0.9	-1.4	-1.4	1.4
Medication: Ramipril	0.8	1.0	2.4	-1.0	-1.5	-0.9	0.1	-1.2	-1.1	0.4
Medication: Simvastatin	0.4	0.6	2.3	-0.6	-0.6	0.1	1.0	1.5	0.4	-0.5
Fluid intelligence score	0.3	0.5	1.3	-0.7	-0.6	-1.1	0.1	-0.7	-1.0	0.0
Illnesses of siblings	0.2	0.3	1.0	0.8	0.3	-0.4	0.0	0.5	1.0	-0.1
Neuroticism score	1.3	2.7	6.4	2.5	2.3	0.2	-2.0	-0.0	-0.2	1.8
Weight	0.2	1.1	2.9	0.3	0.6	-1.5	-0.7	-1.1	-0.5	1.7
Impedance of arm (right)	1.1	5.4	12.1	2.2	1.7	2.4	0.7	3.4	3.5	-0.1
Arm fat percentage (right)	0.6	2.3	5.6	1.1	2.1	-2.4	-0.9	0.1	0.7	2.0
Trunk fat-free mass	0.3	1.5	3.7	-0.6	-1.5	-0.1	-0.4	-1.9	-1.9	0.6
Hip circumference	0.4	1.8	4.7	-0.2	0.6	-2.2	-0.4	-1.8	-0.4	2.0
Time employed in main current job	0.4	0.4	1.6	0.4	1.3	-0.9	-0.1	-0.6	-0.1	0.4
Alcohol intake versus 10 years previously	1.6	2.4	4.8	0.8	1.3	-2.2	-1.5	-0.9	-1.4	2.1
Father’s age at death	1.8	2.5	8.8	1.2	1.7	1.1	0.3	0.6	3.0	-1.5
Worrier / anxious feelings	4.1	7.8	19.2	4.4	3.8	0.8	-3.4	1.8	1.4	1.9
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	6.0	1.8	1.7	-0.3	-2.5	-1.1	-1.0	2.2
Falls in the last year	0.2	0.3	0.7	0.8	0.8	0.0	-0.2	-0.7	0.5	-0.3
Hair/balding pattern: Pattern 3	0.5	0.7	1.8	-1.0	-1.1	1.3	0.5	-0.1	-0.3	0.7
Number of live births	1.0	1.4	6.2	-1.0	-0.1	-0.3	-0.3	-0.3	-1.5	2.5
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.3	0.6	-0.5	1.5	-0.8	-1.4	-1.0	-0.2
Pulse rate	0.5	0.8	2.2	0.0	0.9	-0.7	0.2	0.5	1.4	-1.5
Happiness	2.8	3.4	7.6	-0.2	-0.3	-0.6	-1.6	-2.6	-2.8	2.5
Noisy workplace	0.1	0.2	0.4	-0.1	-0.1	0.5	0.6	0.7	0.2	0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.6	-1.3	-1.1	1.1	0.9	-0.7	-0.4	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.0	0.5	1.1	-0.5	0.2	0.2	1.5	-1.7
Mouth/teeth dental problems: Dentures	1.1	1.8	5.9	-0.9	-0.7	-1.9	1.1	2.4	0.0	-0.7
Asthma	0.5	1.1	3.7	-1.9	-0.6	1.0	0.0	0.6	-1.1	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	-0.3	-0.6	-0.2	0.5	-1.1	-1.0	0.7
Medication: Cholesterol lowering	0.9	1.4	3.5	0.8	0.5	-1.7	0.4	1.9	0.8	1.2
Depression (self-reported)	1.0	1.2	2.5	1.0	0.8	0.7	-1.6	-1.0	-1.0	1.4
Medication: Lansoprazole	2.8	3.2	6.5	2.0	1.3	-1.1	-2.2	-1.7	-1.3	2.5
Prospective memory result	1.6	1.9	4.4	1.0	0.2	1.1	0.5	2.1	2.1	-1.5
Lung cancer (father)	0.4	0.5	1.6	-0.6	-0.0	-1.3	-0.2	-0.5	-1.1	0.1
Illnesses of mother	0.2	0.3	0.7	-0.2	0.0	-0.9	0.0	-0.8	-0.7	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	3.3	1.4	0.3	1.8	-0.7	-0.3	-0.2	0.1
Pulse wave Arterial Stiffness index	1.7	2.0	7.2	-1.5	-0.7	-1.6	0.2	-1.2	-0.1	-2.7
Impedance of arm (left)	1.4	6.6	16.3	2.7	2.3	2.3	0.4	3.5	4.0	-0.3
Arm fat mass (right)	0.5	1.9	4.7	0.8	1.6	-2.0	-0.9	-0.6	0.1	2.2
Trunk predicted mass	0.2	1.4	3.6	-0.6	-1.4	-0.1	-0.5	-1.9	-1.9	0.6
Standing height	0.1	1.3	5.0	1.0	-0.7	2.2	0.6	0.6	1.2	-0.6
Length of working week for main job	0.3	0.3	1.2	-0.1	0.1	1.1	0.5	-0.6	0.6	0.2
Exposure to tobacco smoke at home	0.4	0.4	1.4	1.1	0.3	-0.4	0.1	1.2	0.1	0.2
Breastfed as a baby	0.7	0.8	2.1	-1.2	-0.1	-1.1	0.5	-1.5	-0.3	-0.9
Tense / ‘highly strung’	0.3	0.4	1.1	0.5	0.6	-0.6	-0.9	-0.3	-1.1	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.0	0.5	0.0	0.1	-1.1	-0.6	-1.4	1.1
Hair/balding pattern: Pattern 4	1.0	2.4	5.9	1.7	2.4	-1.8	-0.9	0.5	1.9	-0.6
Birth weight of first child	0.4	0.7	2.4	-0.2	0.3	0.6	-0.3	-1.5	-0.0	1.5
Peak expiratory flow (PEF)	0.1	0.3	1.0	-0.4	-0.1	0.3	0.7	-0.1	0.2	-1.0
Pulse wave reflection index	0.7	0.9	2.3	-0.8	-1.1	0.1	-0.5	-1.5	-1.0	-0.9
Ever highly irritable/argumentative for 2 days	2.0	2.4	6.4	-1.2	-1.1	-0.9	-1.0	-1.8	-2.5	1.6
Loud music exposure frequency	1.7	1.8	5.6	2.4	2.0	0.7	-1.6	0.4	0.0	0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.1	-1.0	-1.0	0.6	1.8	0.7	0.5	-1.4
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	5.2	1.9	2.3	-2.2	-1.7	-1.4	0.5	-0.3
Blood clot in the leg (DVT)	0.2	0.2	0.7	0.4	0.7	0.3	0.2	0.8	0.3	0.0
Medication: Paracetamol	1.1	1.9	4.1	1.9	1.6	-0.6	-2.0	-0.9	-0.1	1.4
Headache pain in last month	1.6	2.8	6.1	0.8	1.6	-2.5	-2.0	-2.2	-0.7	0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.5	-0.3	-0.2	1.1	-0.6	-1.6	-1.0	0.2
Glaucoma (self-reported)	3.2	3.8	9.3	0.9	0.9	1.6	1.2	3.0	2.8	-1.9
Gout (self-reported)	0.5	0.7	3.1	0.2	0.7	-1.8	-0.4	0.3	-0.8	-0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.9	-0.2	-1.1	2.0	0.4	0.7	0.2	-0.1
Medication: Amlodipine	0.4	0.5	2.0	-0.5	-0.3	-1.4	0.4	0.5	-0.0	-0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	-1.1	-0.7	0.3	-0.5	-0.7	-0.5	0.0
Birth weight	0.2	0.5	1.5	-0.5	0.0	-0.7	0.1	-0.7	0.8	-1.2
Chronic bronchitis/emphysema (mother)	1.6	1.9	8.2	-0.1	-0.4	0.6	-0.7	-0.8	-1.9	2.9
High blood pressure (siblings)	0.3	0.5	1.7	-0.6	-0.2	-0.1	-0.1	-0.9	-1.3	0.5
Forced vital capacity (FVC), Best measure	0.3	1.2	6.1	1.4	0.0	2.5	-0.4	-0.1	-0.1	0.3
Body fat percentage	0.7	2.9	9.5	1.1	2.3	-3.1	-0.5	0.0	1.4	1.5
Leg fat percentage (right)	0.9	3.1	12.2	0.8	2.2	-3.5	-0.8	-0.8	0.8	1.6
Arm fat-free mass (right)	0.3	1.8	5.3	-0.7	-1.0	-1.2	-0.6	-2.3	-1.9	0.6
Exposure to tobacco smoke outside home	1.0	1.3	3.4	1.5	0.4	1.8	-0.8	1.3	-0.1	1.1
Comparative body size at age 10	0.3	0.8	5.1	0.1	0.5	-0.3	-0.5	-0.2	-0.2	2.3
Number of full brothers	0.3	0.4	1.0	-0.5	0.3	-0.8	-0.6	-0.8	0.2	-1.0
Worry too long after embarrassment	1.7	2.8	7.2	2.1	1.9	1.1	-1.8	-0.0	0.2	2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.8	0.7	0.3	-0.4	-0.9	-0.9	-1.7	1.7
Wheeze or whistling in the chest in last year	1.0	1.8	6.2	0.2	1.0	-0.0	-2.5	-0.7	-1.6	1.5
Number of children fathered	1.9	2.1	6.1	1.2	1.3	-0.8	0.7	1.6	2.5	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.4	1.2	0.1	0.5	0.1	0.6	0.4	-0.5
Age at first live birth	1.3	2.3	6.7	1.2	1.2	1.1	0.6	0.7	2.6	-2.1
Pulse wave peak to peak time	1.8	2.1	8.2	1.7	0.7	1.5	-0.4	1.0	0.1	2.9
Health satisfaction	0.8	1.0	4.4	1.1	0.7	0.3	-0.7	0.6	-0.4	2.1
Shortness of breath walking on level ground	0.5	0.6	2.2	0.6	0.3	0.8	-0.5	0.6	-0.3	1.5
Qualifications: College or University degree	0.9	2.8	8.2	-1.9	-2.2	2.9	1.3	-0.2	-0.9	-0.7
Eye problems/disorders: None of the above	1.3	1.5	4.2	-2.1	-1.4	-0.8	1.1	-0.5	-1.3	0.9
Mouth/teeth dental problems: Loose teeth	1.3	1.5	4.1	-0.8	-0.7	-0.1	-1.2	-1.6	-2.0	1.3
Emphysema/chronic bronchitis	0.4	0.4	1.4	0.1	1.2	-0.9	-0.5	0.7	-0.0	0.2
Medication for pain relief, constipation, heartburn	0.3	0.6	1.9	-0.7	-0.8	1.0	-0.0	0.4	-0.2	-1.4
Neck or shoulder pain in last month	1.0	1.5	4.2	-0.6	-0.7	1.4	-0.9	-1.4	-2.1	0.8
Medication: Blood pressure	0.3	0.6	1.0	1.0	0.6	-1.0	-1.0	0.4	0.0	0.8
Angina (self-reported)	1.1	1.5	6.2	1.0	0.7	-0.7	0.5	2.5	1.2	0.6
Migraine (self-reported)	0.2	0.3	0.5	-0.2	0.6	-0.2	-0.6	-0.7	-0.6	0.6
Medication: Ibuprofen	0.4	0.5	1.2	-0.7	-0.8	-0.1	0.7	-0.6	-1.1	0.6
Medication: Allopurinol	0.4	0.5	1.5	0.5	1.1	-1.2	-0.4	0.5	0.1	-0.4
Medication: Omeprazole	1.1	1.3	5.2	-0.0	0.3	0.5	1.4	2.3	1.1	-0.9
Medication: Seretide 50 evohaler	0.5	0.6	1.5	0.7	1.2	0.3	-0.9	0.4	0.0	1.0
Mean time to correctly identify matches	0.5	0.9	3.2	-0.3	0.4	-0.3	0.8	0.9	1.8	-1.1
Heart disease (mother)	0.3	0.4	0.7	-0.8	-0.4	-0.7	-0.1	-0.0	-0.9	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	-0.2	-0.0	-0.4	0.5	0.2	0.6	0.4
Whole body fat mass	0.5	2.1	7.6	0.9	1.6	-2.8	-0.5	-0.5	0.8	1.6
Leg fat mass (right)	0.6	2.2	9.2	0.5	1.4	-3.0	-0.6	-1.0	0.1	1.6
Arm predicted mass (right)	0.4	2.0	6.1	-0.8	-0.9	-1.5	-0.6	-2.5	-1.9	0.7
Pulse rate, automated reading	0.2	0.7	1.5	-0.1	1.2	-1.1	0.2	0.5	1.1	-0.5
Alcohol intake frequency.	0.3	0.6	1.4	0.6	1.2	-0.7	-0.2	0.2	0.6	1.2
Comparative height size at age 10	0.2	0.9	2.8	1.0	0.6	0.1	-1.0	-1.1	0.4	1.7
Number of full sisters	2.0	2.5	6.6	0.3	0.4	-2.6	-0.9	-1.9	-1.4	2.0
Suffer from ‘nerves’	0.5	0.9	2.5	1.6	1.0	0.9	-1.2	-0.2	-0.2	0.3
Overall health rating	1.9	4.0	9.1	2.3	2.0	-1.0	-3.0	-0.5	-1.5	2.5
Chest pain or discomfort	1.0	1.5	4.2	-0.8	-0.4	1.2	-0.5	-0.6	-2.0	1.8
Had major operations	0.7	0.8	3.5	0.2	0.1	0.5	-0.8	0.4	-1.1	1.9
Age at last live birth	0.4	0.6	2.4	-0.1	-0.5	1.1	0.4	-0.5	0.3	-1.6
Family relationship satisfaction	1.9	2.3	5.3	-0.8	-0.8	1.4	-0.6	-1.6	-2.1	2.3
Leg pain on walking	0.9	1.2	4.6	-0.6	-0.7	0.8	-0.9	-0.1	-2.2	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	7.0	1.5	1.9	-2.7	-0.8	0.5	1.1	-0.6
Commuting to job workplace: Car/motor vehicle	3.4	3.9	10.6	-2.3	-2.0	-1.4	-0.0	-2.3	-3.3	0.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.4	-1.2	-0.9	0.9	0.7	0.7	-0.8	0.8
Medication: Aspirin	0.2	0.3	1.1	-0.4	-0.1	-0.6	0.3	-0.5	-0.2	1.1
Supplements: Vitamin C	0.1	0.1	0.4	-0.2	0.2	-0.6	0.1	-0.2	0.1	0.1
Knee pain experienced in last month	0.2	0.4	0.9	-0.2	-0.7	0.9	-0.0	-0.5	-1.0	-0.4
Hypertension (Self-reported)	0.4	1.2	2.0	0.7	1.1	-1.4	-1.4	-0.1	-1.0	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.0	0.6	1.0	0.2	-0.7	0.4	0.1	1.4
Illnesses of father: Heart disease	1.1	1.5	4.2	-2.0	-1.7	0.5	1.5	0.4	-1.1	0.3
Illnesses of siblings: Diabetes	0.9	1.2	3.1	-1.8	-1.1	1.5	0.8	0.1	-0.2	-0.9
Smoking status: Previous	0.2	0.3	1.2	-0.7	0.5	-1.1	0.2	0.4	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.5	-0.7	0.1	0.5	0.4	0.1	0.0	0.3
Whole body fat-free mass	0.3	1.5	3.6	-0.6	-1.3	-0.5	-0.5	-1.9	-1.9	0.8
Leg fat-free mass (right)	0.2	1.3	3.4	-0.4	-1.1	-0.5	-0.6	-1.7	-1.9	0.9
Arm fat percentage (left)	0.6	2.5	6.5	1.2	2.1	-2.5	-0.9	-0.1	0.8	1.9
Average weekly red wine intake	0.7	1.0	2.5	-0.9	-1.0	1.6	1.3	0.7	0.5	0.2
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.8	0.6	-0.1	-0.9	-0.9	-1.7	0.6	-1.4
Mood swings	2.1	3.9	8.5	2.9	2.5	-1.8	-2.7	-0.8	-0.1	1.2
Loneliness, isolation	1.3	1.8	4.3	0.7	0.2	-1.0	-1.4	-1.6	-1.6	2.1
Long-standing illness, disability or infirmity	0.7	1.1	3.7	0.4	0.0	1.9	-1.0	0.0	-1.1	1.3
Ever had bowel cancer screening	0.9	1.0	2.2	0.6	1.4	0.4	0.8	1.5	1.4	-0.3
Diabetes diagnosed by doctor	0.5	0.8	2.8	0.4	0.8	-1.3	-0.5	-0.1	-0.2	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.1	-0.4	0.3	-1.0	0.9	1.1	0.9	-0.4
Friendships satisfaction	1.4	1.7	5.1	-0.1	0.2	-0.3	-1.0	-1.9	-1.4	2.2
Qualifications: nursing, teaching	0.3	0.4	1.6	0.0	-0.0	-0.5	-0.2	-1.0	0.3	-1.3
Commuting to job workplace: Walk	0.5	0.5	1.5	0.4	0.4	1.2	-0.3	0.4	0.1	1.1
Eye problems/disorders: Cataract	0.9	1.0	2.1	1.2	0.7	1.4	-0.5	1.4	0.8	0.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.8	1.1	0.5	0.9	-1.3	-0.3	-0.5	0.9
Medication for cholesterol	0.5	0.7	1.1	1.0	0.8	-0.7	-1.1	-0.8	0.9	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.8	0.5	0.1	0.6	-0.1	0.4	0.0	0.9
Back pain experienced in last month	0.3	0.4	1.3	0.5	0.5	-0.7	-0.7	-1.1	-0.4	-0.1
Mineral and other dietary supplements	1.7	2.3	5.1	-2.3	-1.5	-1.8	2.2	0.5	-0.4	-0.7
Breast cancer (self-reported)	0.7	0.9	2.2	-0.3	-0.2	1.5	-1.0	-0.2	-1.1	1.2
Asthma (self-reported)	0.7	1.3	4.0	-2.0	-0.6	1.0	-0.2	0.5	-1.4	1.3
Osteoporosis (self-reported)	2.9	3.6	10.2	3.2	2.7	-0.1	-1.8	0.9	1.8	-0.2
Osteoarthritis (self-reported)	1.0	1.3	3.6	1.8	1.9	0.5	-1.4	0.2	0.5	0.1
Medication: Aspirin	0.2	0.2	1.0	-0.3	-0.1	-1.0	0.2	-0.3	-0.0	0.5
Medication: Gliclazide	0.4	0.4	1.8	-0.3	0.3	-1.4	0.4	0.3	0.8	0.1
Illnesses of father: None of the above (group 1)	1.7	2.1	4.6	1.9	2.1	-0.8	-1.5	0.0	1.6	-1.1
Smoking status: Current	1.1	1.7	3.9	-2.0	-1.8	-0.5	0.5	-1.1	-1.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.8	2.2	0.8	1.3	-1.1	-0.5	0.6	-0.2
Whole body water mass	0.3	1.4	3.6	-0.5	-1.3	-0.4	-0.6	-1.9	-1.9	0.8
Leg predicted mass (right)	0.2	1.2	3.2	-0.4	-1.0	-0.5	-0.6	-1.7	-1.8	0.9
Arm fat mass (left)	0.5	2.0	4.8	0.8	1.5	-2.2	-1.0	-0.8	0.0	2.1
Number of self-reported non-cancer illnesses	0.4	0.6	1.4	0.4	1.2	-0.2	-0.2	1.1	-0.7	1.2
Average weekly champagne plus white wine intake	0.6	0.8	1.6	1.3	1.2	-0.9	-0.8	0.7	0.5	-0.0
Miserableness	1.4	2.4	5.2	1.8	1.4	0.9	-2.0	-0.5	-1.2	2.3
Guilty feelings	1.2	1.8	5.5	2.4	1.9	-0.7	-1.0	0.8	1.1	0.2
Wears glasses or contact lenses	1.5	1.7	7.7	1.1	0.2	2.8	-0.3	1.0	1.0	-1.0
Ever taken oral contraceptive pill	0.2	0.2	0.9	-0.2	-0.1	1.0	0.5	0.4	-0.3	0.2
Hearing aid user	0.5	0.6	1.8	-0.0	-0.2	0.8	-0.6	-0.9	-1.3	0.6
Mother’s age at death	0.5	0.7	2.5	0.7	0.4	1.6	-0.9	-0.3	0.3	-0.7
Financial situation satisfaction	3.6	4.5	12.4	1.6	0.6	0.1	-3.0	-1.8	-2.1	3.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.2	1.1	0.9	-1.5	-0.3	0.2	1.1	0.2
Commuting to job workplace: Public transport	2.0	2.3	6.1	1.9	1.4	1.5	0.1	1.3	2.5	-0.6
Eye problems/disorders: Glaucoma	1.6	1.9	5.5	1.5	1.8	0.1	0.0	1.3	2.3	-0.9
Medication: Blood pressure	0.3	0.7	1.6	-1.2	-0.8	-0.8	0.2	-0.1	-1.3	0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.4	1.6	0.1	0.4	0.4	-0.3	-0.7	-0.7	1.3
Supplements: Fish oil (including cod liver oil)	2.1	2.8	7.0	2.6	1.9	1.5	-1.6	0.7	1.8	0.2
High cholesterol (Self-reported)	0.4	0.7	1.8	-0.6	-0.4	-1.4	1.0	1.0	0.2	-0.6
Medication: Bendroflumethiazide	0.3	0.5	1.9	-1.4	-0.4	-0.6	0.9	-0.1	-0.3	0.1
Medication: Paracetamol	0.6	0.9	1.8	0.7	0.7	-1.1	-1.3	-1.1	-0.6	0.7
Medication: Lisinopril	1.0	1.3	3.3	1.6	1.8	-0.5	-1.2	-0.0	0.4	1.2
Medication: Atorvastatin	0.6	0.7	1.8	0.1	-0.4	-1.3	0.6	0.5	-0.8	1.3
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.6	0.8	-0.1	0.1	-0.3	0.1	0.7
Alcohol drinker status: Never	0.3	0.4	1.6	0.1	-0.1	0.4	0.8	-0.2	1.3	-0.5
Ever smoked	0.6	1.0	3.2	-1.1	-0.4	-0.8	-0.8	-1.0	-1.8	0.6
Basal metabolic rate	0.2	1.3	3.3	-0.4	-0.9	-0.7	-0.5	-1.8	-1.7	1.1
Leg fat percentage (left)	1.0	3.7	14.4	0.9	2.5	-3.8	-1.1	-1.0	0.7	1.4
Arm fat-free mass (left)	0.3	1.5	4.4	-0.5	-0.8	-1.1	-0.6	-2.1	-1.6	1.1
Number of operations (self-reported)	0.7	1.0	3.7	-0.8	0.1	-0.2	-0.3	0.3	-1.9	1.6
Average weekly beer plus cider intake	1.2	1.8	7.1	-0.4	-0.7	0.2	-1.0	-1.8	-2.7	0.8
Irritability	1.8	3.1	9.5	-0.4	-0.9	-1.2	-1.5	-2.2	-3.1	1.8
Risk taking	0.3	0.4	0.9	0.8	0.9	-0.3	0.3	0.5	1.0	-0.1
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.8	-0.9	-0.6	0.3	0.4	0.2	-0.8	0.6
Fractured/broken bones in last 5 years	0.9	1.2	2.6	0.4	-0.7	1.3	-0.8	-0.9	-1.4	1.6
Age started oral contraceptive pill	1.9	2.4	5.4	2.3	1.8	0.6	-0.6	1.9	1.9	0.1
Diastolic blood pressure, automated reading	0.6	1.8	6.2	1.5	2.5	-1.6	-0.8	-0.1	0.9	-0.1
Ever depressed for a whole week	0.5	0.6	3.3	-0.2	-0.0	0.2	-0.5	-0.0	-0.6	1.8
Unable to work because of sickness or disability	0.2	0.3	1.5	0.2	0.2	-0.2	-0.3	-1.2	-0.2	-0.2
Commuting to job workplace: Cycle	0.9	1.1	3.3	0.1	0.3	1.8	-1.1	-1.2	-0.5	1.1
Myopia	1.3	1.9	5.5	-1.3	-1.6	2.4	1.3	0.7	-0.4	1.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.4	-0.7	-0.8	1.1	1.0	-0.3	0.8	-1.5
Cholesterol lowering medication	0.6	0.8	2.0	-1.4	-1.4	0.4	0.7	-0.0	-1.1	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.3	0.2	0.9	0.5	1.0	1.5	1.3	-0.2
Pain experienced in last month	0.5	0.8	1.7	0.2	-0.0	1.3	0.9	1.1	1.2	0.6
Supplements: Calcium	0.6	0.7	2.1	0.3	-1.2	0.6	-0.6	-0.0	-1.4	-0.7
Basal cell carcinoma (self-reported)	0.7	0.9	2.9	0.3	0.1	1.7	0.9	1.0	1.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.7	0.0	0.1	-1.6	0.6	0.3	0.6	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.7	0.2	0.6	0.6	0.8	1.3	0.5	-0.1
Heart disease (siblings)	0.5	0.7	1.9	1.4	0.3	0.5	-0.6	0.8	0.0	1.2
Alcohol drinker status: Previous	1.0	1.1	2.9	-1.2	-1.1	-0.5	-0.0	-1.2	-1.7	0.6
Pack years of smoking	1.1	1.7	9.6	0.5	0.3	-3.1	-0.3	0.2	-0.4	1.2
Impedance of whole body	1.0	4.9	14.8	2.1	2.3	1.3	0.5	2.6	3.8	-0.7
Leg fat mass (left)	0.6	2.3	9.2	0.3	1.3	-3.0	-0.8	-1.3	-0.1	1.5
Arm predicted mass (left)	0.3	1.4	4.7	-0.6	-0.9	-1.0	-0.5	-2.2	-1.6	0.7