Hub : Genes

PLXDC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1220 0.0320 5.9e-08 0.107 0.061 0.070 0.060 0.040 5.8e-13 6.8e-08 6.9e-09 8.3e-08 9.9e-06
2 GTEx Skin Sun Exposed Lower leg 0.1710 0.0540 1.5e-04 0.095 NA 0.069 NA 0.075 2.7e-08 NA 2.1e-06 NA 7.9e-07
3 GTEx Spleen 0.4340 0.1190 4.3e-03 0.046 NA 0.115 NA 0.084 2.6e-02 NA 7.0e-04 NA 3.6e-03
4 GTEx Whole Blood 0.2120 0.0430 5.2e-12 0.159 NA 0.187 NA 0.183 1.6e-14 NA 5.5e-17 NA 1.1e-16
5 NTR Blood 0.0291 0.0122 1.4e-03 0.000 0.009 0.016 0.012 0.005 3.3e-01 3.6e-04 4.4e-06 5.8e-05 6.3e-03
6 YFS Blood 0.0271 0.0094 6.7e-05 0.025 0.016 0.018 0.016 0.020 1.2e-08 3.1e-06 1.4e-06 5.3e-06 2.9e-07
7 TCGA Prostate Adenocarcinoma 0.0446 0.0246 7.8e-03 0.006 0.014 0.000 NA 0.003 6.9e-02 1.1e-02 3.0e-01 NA 1.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.5 2.4 6.6 -2.6 -2.0 0.8 2.0 -0.8 -0.9 -0.5
Bipolar Disorder or Schizophrenia 1.2 2.9 6.7 -2.6 -2.4 1.4 0.8 -1.2 -2.0 0.0
Depressed Affect (Nagel 2018) 1.1 2.3 6.8 2.6 2.1 0.4 -1.3 0.3 0.3 1.8
Depression (Nagel 2018) 1.2 1.7 4.7 2.2 1.8 -0.8 -1.9 0.1 0.2 -0.1
Intelligence (Savage-Jansen 2018) 0.7 2.2 5.0 -1.7 -2.2 2.0 1.1 0.2 -1.3 -0.5
Neuroticism (Nagel 2018) 1.1 2.5 7.7 2.8 2.4 0.4 -1.3 0.3 0.6 1.4
Schizophrenia (2018) 0.6 1.3 3.3 -1.2 -1.5 1.0 -0.6 -0.8 -1.8 0.4
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 -0.8 -1.0 0.1 0.9 0.6 -0.7 -0.5
Worry (Nagel 2018) 1.3 2.7 8.6 2.9 2.4 0.8 -1.9 0.4 0.6 0.5
Alzheimer’s Disease (in mother) 1.5 1.8 2.8 -1.3 -1.4 1.6 1.7 0.7 0.4 -1.6
Alzheimer’s Disease (in father) 1.0 1.1 2.4 -1.6 -1.3 -0.1 1.5 0.2 0.3 -0.9
Alzheimer’s Disease (including proxy) 1.1 1.6 3.1 -0.7 -0.6 1.5 1.8 1.4 1.2 -1.4
Crohns Disease (2017) 0.3 0.6 1.2 0.3 -0.9 0.6 -0.6 -0.7 -0.9 1.1
Irritable Bowel Disease (IBD) 0.4 0.9 2.7 1.3 0.1 -0.2 -1.2 -0.7 -0.4 1.6
Ulcerative Colitis (UC) 0.6 1.1 2.0 1.3 0.7 -1.1 -1.3 -0.8 0.1 1.4
Major Depression (MDD) 0.6 0.7 1.4 -1.0 -1.1 -0.3 1.0 -0.3 -0.2 -1.2
Reaction Time 0.4 0.8 2.2 -0.8 -0.3 -0.5 0.9 -0.1 1.2 -1.5
Verbal and Numeric Reasoning (VNR) 1.1 2.7 6.5 -2.5 -2.4 -0.1 1.1 -1.1 -2.0 -0.4
Breast Cancer 0.1 0.1 0.4 0.2 -0.6 0.2 -0.2 -0.6 0.1 -0.0
Ovarian Cancer 2.7 3.5 8.4 -2.9 -1.8 -1.2 1.9 -1.5 -0.6 -2.3
Prostate Cancer 1.1 1.5 4.8 -1.9 -1.0 -0.3 0.6 -0.8 -0.7 -2.2
Age at First Birth 1.8 2.6 8.1 -0.2 -1.4 2.8 1.5 1.5 1.0 -1.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.9 2.0 0.5 1.1 -1.4 -0.1 -0.2 0.9 -1.4
Coronary Artery Disease (CAD) 0.5 0.5 2.3 0.9 0.4 -0.2 -1.5 -0.6 0.3 0.0
Crohns Disease (2012) 1.4 2.3 4.8 0.1 -0.7 -1.8 -1.6 -2.2 -1.6 1.6
Mean Putamen Volume 1.3 1.5 6.4 0.4 1.1 -2.5 -0.0 -0.3 0.8 -1.5
Fasting Glucose 1.4 1.6 4.0 -1.8 -1.9 0.7 2.0 -0.1 0.3 0.2
HbA1C 0.9 1.0 3.5 -1.1 -0.6 0.1 1.9 0.9 1.0 -0.5
HDL Cholesterol 1.3 2.1 6.4 -1.2 -2.5 1.5 1.8 -0.4 -1.2 0.0
LDL Cholesterol 1.0 1.6 3.9 -1.7 -2.0 0.1 0.2 -1.1 -1.6 -0.5
Lupus 2.6 4.0 10.2 -1.9 -3.2 2.4 1.3 -0.2 -2.4 -0.7
Neuroticism (2016) 1.0 1.4 3.8 1.6 1.9 -1.1 -0.6 -0.3 1.2 0.5
Primary Biliary Cirrhosis 0.5 0.7 2.9 1.7 1.1 0.1 -0.8 -0.0 -0.2 -0.6
Rheumatoid Arthritis 0.9 1.2 3.3 0.9 0.3 1.3 0.1 1.8 0.4 -1.6
Schizophrenia (2014) 1.0 2.2 4.2 -2.0 -2.1 1.4 0.2 -0.7 -2.0 -0.2
Triglycerides 0.1 0.2 0.5 0.2 0.6 0.0 -0.7 -0.0 -0.1 -0.4
Type 2 Diabetes (T2D) (2012) 1.3 1.5 3.6 0.5 1.5 -1.4 -1.5 -0.5 -0.4 1.9
Ulcerative Colitis 0.5 0.7 1.7 0.5 -0.3 -1.3 -0.2 -0.8 -0.6 1.3
Blood Eosinophil Count 0.5 4.2 9.9 -3.1 -2.5 3.1 1.0 -1.2 -0.9 -0.3
Blood Platelet Count 0.5 5.3 14.7 -2.3 -3.1 0.9 1.8 1.3 -1.3 -3.8
Blood Red Count 1.4 13.3 44.5 -4.8 -0.7 -6.7 -0.1 -4.3 -2.6 -0.2
Blood White Count 1.5 11.0 22.2 -4.7 -3.5 4.7 3.5 2.5 -1.0 0.3
Heel T-Score 0.3 2.4 8.1 -0.9 -0.8 -1.7 0.3 -1.7 1.1 -2.8
BMI 0.4 2.4 5.1 -0.4 0.6 -2.1 -1.0 -2.3 -1.4 1.9
Height 0.2 4.4 11.8 1.7 -1.2 3.4 1.7 2.9 1.8 0.5
Waist Hip Ratio (WHR) 0.2 0.8 3.1 0.1 -0.0 -0.5 -1.2 -0.5 -1.8 0.7
Systolic Blood Pressure 0.2 1.0 1.7 1.0 1.3 -0.9 -0.3 1.1 0.9 -1.1
Smoking Status 0.6 1.4 4.3 -2.1 -1.3 -0.4 1.0 -0.4 -0.5 -1.5
Allergy or Eczema 0.2 0.6 1.4 -1.2 -0.4 0.6 -0.4 -0.8 -0.9 0.8
Cardiovascular Disease 0.3 0.8 3.0 0.4 0.9 -1.7 -1.0 -0.0 -0.6 0.8
Hypothyroidism (self reported) 0.8 1.8 7.4 -1.1 -1.6 2.7 0.8 0.5 -0.6 -0.4
Respiratory disease 0.5 1.1 5.0 -2.2 -0.4 0.7 0.7 0.4 -0.7 0.8
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.2 -1.1 -0.4 -0.6 0.3 0.4 -0.7 1.0
Lung FEV1/FVC ratio 0.2 1.2 3.0 0.2 0.5 -1.6 -0.7 -1.4 0.2 -1.7
Lung FVC 0.3 1.6 5.7 1.8 -0.8 2.4 -0.8 0.3 -0.8 0.3
Neuroticism 1.0 2.3 6.1 2.5 2.5 0.1 -1.5 0.1 0.7 1.0
Chronotype (morning person) 1.2 2.9 7.4 2.7 1.6 2.0 -1.3 1.5 0.9 1.3
Hair Pigment 0.0 1.0 2.3 0.5 -0.5 1.5 -0.5 -0.8 -1.2 1.2
Tanning 0.0 0.3 1.5 0.2 -0.1 1.2 -0.0 0.3 -0.2 0.6
Hand grip strength (left) 0.1 0.3 1.1 -0.6 -0.7 0.2 1.0 0.1 -0.1 -0.1
Number of treatments/medications taken 0.8 1.4 5.1 1.3 1.1 -0.1 0.0 2.2 1.3 0.5
Average weekly spirits intake 0.2 0.2 0.3 -0.3 -0.5 -0.1 0.6 -0.5 -0.5 -0.5
Sensitivity / hurt feelings 1.0 1.6 4.6 1.6 2.1 0.1 -1.0 0.8 0.8 1.5
Frequency of depressed mood in last 2 weeks 2.7 3.8 12.8 1.7 1.4 -0.4 -3.6 -1.4 -1.8 1.8
Hearing difficulty/problems: Yes 0.7 1.1 3.1 1.0 1.0 1.0 -0.0 1.8 1.0 0.9
Relative age of first facial hair 0.2 0.5 1.0 -0.4 -1.0 0.6 0.9 -0.3 -0.9 0.5
Other serious medical condition/disability diagnosed by doctor 1.7 2.2 5.3 2.3 1.7 1.6 -1.1 1.1 1.5 0.5
Ever used hormone-replacement therapy (HRT) 1.0 1.3 2.4 1.5 1.3 1.4 -0.4 1.5 0.9 -0.0
Ever had hysterectomy (womb removed) 0.4 0.5 1.7 0.7 1.3 0.5 -0.7 0.3 0.6 -0.2
Systolic blood pressure, automated reading 0.2 0.7 2.9 0.0 0.6 -0.2 0.5 0.7 0.9 -1.7
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 2.9 1.4 1.7 -1.5 -1.4 -0.7 0.7 -0.8
Angina 1.2 1.6 6.7 0.8 0.6 -0.9 0.8 2.6 1.4 0.1
Medication for hormone replacement therapy 1.0 1.1 4.1 -0.6 -0.1 0.8 1.7 2.0 0.2 0.2
Vitamin and mineral supplements 0.6 0.8 3.3 0.5 1.1 -1.8 -0.3 -0.3 0.2 -0.6
Supplements: Zinc 1.0 1.1 3.6 0.9 0.0 0.2 -1.9 -1.2 -1.3 0.3
Medication: Co-codamol 2.0 2.3 5.5 0.1 0.3 -1.5 -1.8 -1.9 -2.3 1.0
Medication: Metformin 0.6 0.8 1.8 -1.1 -0.4 -0.4 1.3 0.8 -0.4 1.2
Diabetes (father) 2.0 2.5 9.3 -0.9 -1.7 3.0 0.5 -0.1 -1.6 1.2
Diabetes (mother) 0.5 0.6 2.6 0.5 0.5 -1.6 -0.5 -0.9 -0.1 0.0
Severe depression (siblings) 0.6 0.7 2.2 -1.0 -0.2 0.0 1.5 1.0 0.1 -0.6
Pack years adult smoking proportion 1.2 1.9 10.8 -0.0 -0.1 -3.3 -0.3 -0.4 -0.9 1.2
Impedance of leg (right) 0.6 3.0 11.0 1.3 1.7 0.7 1.0 1.9 3.3 -0.7
Leg fat-free mass (left) 0.2 1.2 2.8 -0.5 -1.2 -0.4 -0.3 -1.7 -1.7 1.0
Trunk fat percentage 0.8 3.2 8.2 1.4 2.5 -2.9 -0.5 0.4 1.7 1.5
Hand grip strength (right) 0.1 0.3 0.6 -0.7 -0.7 0.6 0.6 -0.0 -0.4 0.5
Townsend deprivation index at recruitment 0.3 0.5 1.6 -0.9 0.4 -1.3 0.2 -0.7 0.1 -0.4
Current tobacco smoking 1.2 2.0 5.0 -2.2 -1.9 -0.7 0.7 -1.1 -1.3 -1.4
Average weekly fortified wine intake 0.8 1.0 2.2 1.3 0.6 -0.2 -0.2 1.4 1.5 -0.8
Maternal smoking around birth 1.5 2.2 5.8 -1.1 -1.2 -2.4 0.4 -0.9 -1.9 1.6
Fed-up feelings 1.0 1.7 3.3 1.3 1.6 -0.0 -1.8 -0.8 -1.0 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 3.0 1.6 1.7 -1.4 -1.6 -0.5 -0.0 -0.4
Relative age voice broke 0.3 0.4 1.1 0.1 -0.5 1.1 0.9 -0.0 0.1 0.9
Taking other prescription medications 0.9 1.3 6.6 0.6 0.9 0.8 0.1 2.6 0.6 0.8
Age when periods started (menarche) 0.4 0.9 2.0 1.0 -0.1 -0.5 0.8 1.4 0.9 -1.2
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 4.0 1.7 2.0 0.5 -1.1 0.4 0.6 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 9.4 -1.1 -1.6 0.3 2.0 0.5 1.5 -3.1
Tinnitus: Yes, but not now, but have in the past 2.7 2.9 7.0 1.7 0.5 1.6 -2.6 -1.3 -1.7 1.8
Qualifications: CSEs or equivalent 3.7 4.9 9.8 1.3 1.6 -0.2 -3.1 -3.1 -2.1 2.4
Serious illness, injury or assault to yourself 0.9 1.1 2.7 1.6 0.7 0.5 -1.5 0.1 -0.2 1.3
High blood pressure 0.4 1.0 2.1 0.9 1.0 -0.9 -1.3 0.1 -1.0 1.4
Hayfever, allergic rhinitis or eczema 0.7 1.5 3.2 -1.4 -0.8 -0.2 -0.9 -1.4 -1.8 1.4
Multivitamins +/- minerals 2.3 3.0 7.0 -1.7 -2.6 2.6 1.0 0.2 -1.4 0.9
Stomach or abdominal pain in last month 3.4 4.2 10.5 1.2 1.7 -3.2 -2.5 -2.5 -0.9 1.1
Supplements: Glucosamine 2.8 3.6 8.8 3.0 2.6 1.0 -2.8 -0.5 0.8 0.6
Diverticular disease/diverticulitis (self-reported) 2.3 2.7 6.5 0.2 1.4 0.8 1.2 2.6 2.4 -1.7
Medication: Atenolol 0.5 0.6 1.9 -0.0 -0.4 -0.1 -1.1 -0.7 -1.4 0.5
Medication: Levothyroxine sodium 0.8 1.3 6.0 0.3 -0.9 2.5 -0.1 1.4 -0.1 0.3
Sitting height 0.1 0.9 2.6 -0.4 -1.4 1.0 1.6 0.4 0.3 -0.4
Chronic bronchitis/emphysema (father) 0.2 0.2 0.7 0.3 0.2 -0.8 0.0 0.5 0.4 0.0
High blood pressure (mother) 0.3 0.5 1.1 0.8 1.0 0.7 -0.6 -0.0 0.8 0.1
Body mass index (BMI) 0.6 2.5 7.3 -0.1 1.1 -2.7 -1.1 -1.4 -1.1 2.2
Impedance of leg (left) 0.6 2.8 9.9 1.3 2.1 0.1 0.5 1.6 3.1 -0.9
Leg predicted mass (left) 0.2 1.2 2.9 -0.5 -1.2 -0.4 -0.3 -1.6 -1.7 1.0
Trunk fat mass 0.5 2.3 8.1 1.1 1.9 -2.8 -0.6 -0.2 1.0 1.4
Waist circumference 0.3 1.1 3.2 0.1 0.8 -1.8 -0.9 -0.9 -0.7 1.3
Number of incorrect matches in round 0.5 0.8 2.5 -0.7 0.2 1.6 0.3 0.5 1.0 -1.0
Past tobacco smoking 0.4 0.7 2.3 1.5 0.6 0.7 -0.2 0.3 1.2 -0.0
Alcohol usually taken with meals 0.7 1.1 4.3 0.7 0.8 2.1 0.1 1.0 1.0 0.3
Nervous feelings 1.6 3.0 8.5 2.9 2.1 1.9 -1.7 0.7 0.9 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.2 0.8 0.4 -0.1 -1.4 -0.4 -1.5 0.6
Hearing difficulty/problems with background noise 1.3 2.0 6.0 0.1 0.1 2.1 1.6 2.5 1.0 0.4
Hair/balding pattern: Pattern 2 0.4 0.6 1.6 -0.6 -0.6 0.8 1.3 0.6 0.4 -0.6
Had menopause 0.2 0.3 0.8 0.5 0.6 0.4 -0.2 -0.2 0.4 0.9
Had other major operations 1.0 1.2 4.6 -1.4 -1.2 -0.2 0.3 0.1 -2.2 0.7
Forced vital capacity (FVC) 0.3 1.2 5.9 0.8 -0.7 2.4 -0.7 -0.7 -0.8 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 5.3 -1.2 -1.8 0.2 1.4 0.1 0.1 -2.3
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 2.7 0.4 -0.0 0.7 -1.0 -1.4 -1.3 1.6
Qualifications: None of the above 0.4 0.9 2.7 0.9 1.2 -1.6 -0.4 0.8 0.9 -0.2
Financial difficulties in last 2 years 0.3 0.4 0.9 0.6 1.0 -0.7 -0.6 -0.3 0.2 0.5
Mouth/teeth dental problems 0.4 0.6 2.3 -0.4 -0.4 1.5 0.2 -0.7 -0.2 1.0
Heart attack 0.4 0.5 2.1 0.2 0.1 -1.5 0.6 0.6 0.7 0.2
Allergy 1.0 2.2 5.3 2.2 1.0 0.4 0.7 1.4 2.3 -1.4
Pain all over the body in last month 1.0 1.1 2.7 1.5 1.7 -0.8 -1.0 0.2 1.0 0.4
Diabetes (self-reported) 0.3 0.5 2.7 0.3 0.3 -0.8 -0.3 -0.1 -0.3 1.7
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.1 -0.5 -0.5 0.8 -0.9 -1.4 -1.4 1.4
Medication: Ramipril 0.8 1.0 2.4 -1.0 -1.5 -0.9 0.1 -1.2 -1.1 0.4
Medication: Simvastatin 0.4 0.6 2.3 -0.6 -0.6 0.1 1.0 1.5 0.4 -0.5
Fluid intelligence score 0.3 0.5 1.3 -0.7 -0.6 -1.1 0.1 -0.7 -1.0 0.0
Illnesses of siblings 0.2 0.3 1.0 0.8 0.3 -0.4 0.0 0.5 1.0 -0.1
Neuroticism score 1.3 2.7 6.4 2.5 2.3 0.2 -2.0 -0.0 -0.2 1.8
Weight 0.2 1.1 2.9 0.3 0.6 -1.5 -0.7 -1.1 -0.5 1.7
Impedance of arm (right) 1.1 5.4 12.1 2.2 1.7 2.4 0.7 3.4 3.5 -0.1
Arm fat percentage (right) 0.6 2.3 5.6 1.1 2.1 -2.4 -0.9 0.1 0.7 2.0
Trunk fat-free mass 0.3 1.5 3.7 -0.6 -1.5 -0.1 -0.4 -1.9 -1.9 0.6
Hip circumference 0.4 1.8 4.7 -0.2 0.6 -2.2 -0.4 -1.8 -0.4 2.0
Time employed in main current job 0.4 0.4 1.6 0.4 1.3 -0.9 -0.1 -0.6 -0.1 0.4
Alcohol intake versus 10 years previously 1.6 2.4 4.8 0.8 1.3 -2.2 -1.5 -0.9 -1.4 2.1
Father’s age at death 1.8 2.5 8.8 1.2 1.7 1.1 0.3 0.6 3.0 -1.5
Worrier / anxious feelings 4.1 7.8 19.2 4.4 3.8 0.8 -3.4 1.8 1.4 1.9
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.8 6.0 1.8 1.7 -0.3 -2.5 -1.1 -1.0 2.2
Falls in the last year 0.2 0.3 0.7 0.8 0.8 0.0 -0.2 -0.7 0.5 -0.3
Hair/balding pattern: Pattern 3 0.5 0.7 1.8 -1.0 -1.1 1.3 0.5 -0.1 -0.3 0.7
Number of live births 1.0 1.4 6.2 -1.0 -0.1 -0.3 -0.3 -0.3 -1.5 2.5
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.3 0.6 -0.5 1.5 -0.8 -1.4 -1.0 -0.2
Pulse rate 0.5 0.8 2.2 0.0 0.9 -0.7 0.2 0.5 1.4 -1.5
Happiness 2.8 3.4 7.6 -0.2 -0.3 -0.6 -1.6 -2.6 -2.8 2.5
Noisy workplace 0.1 0.2 0.4 -0.1 -0.1 0.5 0.6 0.7 0.2 0.4
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.6 -1.3 -1.1 1.1 0.9 -0.7 -0.4 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 3.0 0.5 1.1 -0.5 0.2 0.2 1.5 -1.7
Mouth/teeth dental problems: Dentures 1.1 1.8 5.9 -0.9 -0.7 -1.9 1.1 2.4 0.0 -0.7
Asthma 0.5 1.1 3.7 -1.9 -0.6 1.0 0.0 0.6 -1.1 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.1 -0.3 -0.6 -0.2 0.5 -1.1 -1.0 0.7
Medication: Cholesterol lowering 0.9 1.4 3.5 0.8 0.5 -1.7 0.4 1.9 0.8 1.2
Depression (self-reported) 1.0 1.2 2.5 1.0 0.8 0.7 -1.6 -1.0 -1.0 1.4
Medication: Lansoprazole 2.8 3.2 6.5 2.0 1.3 -1.1 -2.2 -1.7 -1.3 2.5
Prospective memory result 1.6 1.9 4.4 1.0 0.2 1.1 0.5 2.1 2.1 -1.5
Lung cancer (father) 0.4 0.5 1.6 -0.6 -0.0 -1.3 -0.2 -0.5 -1.1 0.1
Illnesses of mother 0.2 0.3 0.7 -0.2 0.0 -0.9 0.0 -0.8 -0.7 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 3.3 1.4 0.3 1.8 -0.7 -0.3 -0.2 0.1
Pulse wave Arterial Stiffness index 1.7 2.0 7.2 -1.5 -0.7 -1.6 0.2 -1.2 -0.1 -2.7
Impedance of arm (left) 1.4 6.6 16.3 2.7 2.3 2.3 0.4 3.5 4.0 -0.3
Arm fat mass (right) 0.5 1.9 4.7 0.8 1.6 -2.0 -0.9 -0.6 0.1 2.2
Trunk predicted mass 0.2 1.4 3.6 -0.6 -1.4 -0.1 -0.5 -1.9 -1.9 0.6
Standing height 0.1 1.3 5.0 1.0 -0.7 2.2 0.6 0.6 1.2 -0.6
Length of working week for main job 0.3 0.3 1.2 -0.1 0.1 1.1 0.5 -0.6 0.6 0.2
Exposure to tobacco smoke at home 0.4 0.4 1.4 1.1 0.3 -0.4 0.1 1.2 0.1 0.2
Breastfed as a baby 0.7 0.8 2.1 -1.2 -0.1 -1.1 0.5 -1.5 -0.3 -0.9
Tense / ‘highly strung’ 0.3 0.4 1.1 0.5 0.6 -0.6 -0.9 -0.3 -1.1 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 2.0 0.5 0.0 0.1 -1.1 -0.6 -1.4 1.1
Hair/balding pattern: Pattern 4 1.0 2.4 5.9 1.7 2.4 -1.8 -0.9 0.5 1.9 -0.6
Birth weight of first child 0.4 0.7 2.4 -0.2 0.3 0.6 -0.3 -1.5 -0.0 1.5
Peak expiratory flow (PEF) 0.1 0.3 1.0 -0.4 -0.1 0.3 0.7 -0.1 0.2 -1.0
Pulse wave reflection index 0.7 0.9 2.3 -0.8 -1.1 0.1 -0.5 -1.5 -1.0 -0.9
Ever highly irritable/argumentative for 2 days 2.0 2.4 6.4 -1.2 -1.1 -0.9 -1.0 -1.8 -2.5 1.6
Loud music exposure frequency 1.7 1.8 5.6 2.4 2.0 0.7 -1.6 0.4 0.0 0.1
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 3.1 -1.0 -1.0 0.6 1.8 0.7 0.5 -1.4
Mouth/teeth dental problems: Bleeding gums 2.1 2.7 5.2 1.9 2.3 -2.2 -1.7 -1.4 0.5 -0.3
Blood clot in the leg (DVT) 0.2 0.2 0.7 0.4 0.7 0.3 0.2 0.8 0.3 0.0
Medication: Paracetamol 1.1 1.9 4.1 1.9 1.6 -0.6 -2.0 -0.9 -0.1 1.4
Headache pain in last month 1.6 2.8 6.1 0.8 1.6 -2.5 -2.0 -2.2 -0.7 0.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.5 -0.3 -0.2 1.1 -0.6 -1.6 -1.0 0.2
Glaucoma (self-reported) 3.2 3.8 9.3 0.9 0.9 1.6 1.2 3.0 2.8 -1.9
Gout (self-reported) 0.5 0.7 3.1 0.2 0.7 -1.8 -0.4 0.3 -0.8 -0.1
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 3.9 -0.2 -1.1 2.0 0.4 0.7 0.2 -0.1
Medication: Amlodipine 0.4 0.5 2.0 -0.5 -0.3 -1.4 0.4 0.5 -0.0 -0.9
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.2 -1.1 -0.7 0.3 -0.5 -0.7 -0.5 0.0
Birth weight 0.2 0.5 1.5 -0.5 0.0 -0.7 0.1 -0.7 0.8 -1.2
Chronic bronchitis/emphysema (mother) 1.6 1.9 8.2 -0.1 -0.4 0.6 -0.7 -0.8 -1.9 2.9
High blood pressure (siblings) 0.3 0.5 1.7 -0.6 -0.2 -0.1 -0.1 -0.9 -1.3 0.5
Forced vital capacity (FVC), Best measure 0.3 1.2 6.1 1.4 0.0 2.5 -0.4 -0.1 -0.1 0.3
Body fat percentage 0.7 2.9 9.5 1.1 2.3 -3.1 -0.5 0.0 1.4 1.5
Leg fat percentage (right) 0.9 3.1 12.2 0.8 2.2 -3.5 -0.8 -0.8 0.8 1.6
Arm fat-free mass (right) 0.3 1.8 5.3 -0.7 -1.0 -1.2 -0.6 -2.3 -1.9 0.6
Exposure to tobacco smoke outside home 1.0 1.3 3.4 1.5 0.4 1.8 -0.8 1.3 -0.1 1.1
Comparative body size at age 10 0.3 0.8 5.1 0.1 0.5 -0.3 -0.5 -0.2 -0.2 2.3
Number of full brothers 0.3 0.4 1.0 -0.5 0.3 -0.8 -0.6 -0.8 0.2 -1.0
Worry too long after embarrassment 1.7 2.8 7.2 2.1 1.9 1.1 -1.8 -0.0 0.2 2.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 2.8 0.7 0.3 -0.4 -0.9 -0.9 -1.7 1.7
Wheeze or whistling in the chest in last year 1.0 1.8 6.2 0.2 1.0 -0.0 -2.5 -0.7 -1.6 1.5
Number of children fathered 1.9 2.1 6.1 1.2 1.3 -0.8 0.7 1.6 2.5 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.4 1.2 0.1 0.5 0.1 0.6 0.4 -0.5
Age at first live birth 1.3 2.3 6.7 1.2 1.2 1.1 0.6 0.7 2.6 -2.1
Pulse wave peak to peak time 1.8 2.1 8.2 1.7 0.7 1.5 -0.4 1.0 0.1 2.9
Health satisfaction 0.8 1.0 4.4 1.1 0.7 0.3 -0.7 0.6 -0.4 2.1
Shortness of breath walking on level ground 0.5 0.6 2.2 0.6 0.3 0.8 -0.5 0.6 -0.3 1.5
Qualifications: College or University degree 0.9 2.8 8.2 -1.9 -2.2 2.9 1.3 -0.2 -0.9 -0.7
Eye problems/disorders: None of the above 1.3 1.5 4.2 -2.1 -1.4 -0.8 1.1 -0.5 -1.3 0.9
Mouth/teeth dental problems: Loose teeth 1.3 1.5 4.1 -0.8 -0.7 -0.1 -1.2 -1.6 -2.0 1.3
Emphysema/chronic bronchitis 0.4 0.4 1.4 0.1 1.2 -0.9 -0.5 0.7 -0.0 0.2
Medication for pain relief, constipation, heartburn 0.3 0.6 1.9 -0.7 -0.8 1.0 -0.0 0.4 -0.2 -1.4
Neck or shoulder pain in last month 1.0 1.5 4.2 -0.6 -0.7 1.4 -0.9 -1.4 -2.1 0.8
Medication: Blood pressure 0.3 0.6 1.0 1.0 0.6 -1.0 -1.0 0.4 0.0 0.8
Angina (self-reported) 1.1 1.5 6.2 1.0 0.7 -0.7 0.5 2.5 1.2 0.6
Migraine (self-reported) 0.2 0.3 0.5 -0.2 0.6 -0.2 -0.6 -0.7 -0.6 0.6
Medication: Ibuprofen 0.4 0.5 1.2 -0.7 -0.8 -0.1 0.7 -0.6 -1.1 0.6
Medication: Allopurinol 0.4 0.5 1.5 0.5 1.1 -1.2 -0.4 0.5 0.1 -0.4
Medication: Omeprazole 1.1 1.3 5.2 -0.0 0.3 0.5 1.4 2.3 1.1 -0.9
Medication: Seretide 50 evohaler 0.5 0.6 1.5 0.7 1.2 0.3 -0.9 0.4 0.0 1.0
Mean time to correctly identify matches 0.5 0.9 3.2 -0.3 0.4 -0.3 0.8 0.9 1.8 -1.1
Heart disease (mother) 0.3 0.4 0.7 -0.8 -0.4 -0.7 -0.1 -0.0 -0.9 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.3 -0.2 -0.0 -0.4 0.5 0.2 0.6 0.4
Whole body fat mass 0.5 2.1 7.6 0.9 1.6 -2.8 -0.5 -0.5 0.8 1.6
Leg fat mass (right) 0.6 2.2 9.2 0.5 1.4 -3.0 -0.6 -1.0 0.1 1.6
Arm predicted mass (right) 0.4 2.0 6.1 -0.8 -0.9 -1.5 -0.6 -2.5 -1.9 0.7
Pulse rate, automated reading 0.2 0.7 1.5 -0.1 1.2 -1.1 0.2 0.5 1.1 -0.5
Alcohol intake frequency. 0.3 0.6 1.4 0.6 1.2 -0.7 -0.2 0.2 0.6 1.2
Comparative height size at age 10 0.2 0.9 2.8 1.0 0.6 0.1 -1.0 -1.1 0.4 1.7
Number of full sisters 2.0 2.5 6.6 0.3 0.4 -2.6 -0.9 -1.9 -1.4 2.0
Suffer from ‘nerves’ 0.5 0.9 2.5 1.6 1.0 0.9 -1.2 -0.2 -0.2 0.3
Overall health rating 1.9 4.0 9.1 2.3 2.0 -1.0 -3.0 -0.5 -1.5 2.5
Chest pain or discomfort 1.0 1.5 4.2 -0.8 -0.4 1.2 -0.5 -0.6 -2.0 1.8
Had major operations 0.7 0.8 3.5 0.2 0.1 0.5 -0.8 0.4 -1.1 1.9
Age at last live birth 0.4 0.6 2.4 -0.1 -0.5 1.1 0.4 -0.5 0.3 -1.6
Family relationship satisfaction 1.9 2.3 5.3 -0.8 -0.8 1.4 -0.6 -1.6 -2.1 2.3
Leg pain on walking 0.9 1.2 4.6 -0.6 -0.7 0.8 -0.9 -0.1 -2.2 1.1
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 7.0 1.5 1.9 -2.7 -0.8 0.5 1.1 -0.6
Commuting to job workplace: Car/motor vehicle 3.4 3.9 10.6 -2.3 -2.0 -1.4 -0.0 -2.3 -3.3 0.2
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 1.4 -1.2 -0.9 0.9 0.7 0.7 -0.8 0.8
Medication: Aspirin 0.2 0.3 1.1 -0.4 -0.1 -0.6 0.3 -0.5 -0.2 1.1
Supplements: Vitamin C 0.1 0.1 0.4 -0.2 0.2 -0.6 0.1 -0.2 0.1 0.1
Knee pain experienced in last month 0.2 0.4 0.9 -0.2 -0.7 0.9 -0.0 -0.5 -1.0 -0.4
Hypertension (Self-reported) 0.4 1.2 2.0 0.7 1.1 -1.4 -1.4 -0.1 -1.0 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 2.0 0.6 1.0 0.2 -0.7 0.4 0.1 1.4
Illnesses of father: Heart disease 1.1 1.5 4.2 -2.0 -1.7 0.5 1.5 0.4 -1.1 0.3
Illnesses of siblings: Diabetes 0.9 1.2 3.1 -1.8 -1.1 1.5 0.8 0.1 -0.2 -0.9
Smoking status: Previous 0.2 0.3 1.2 -0.7 0.5 -1.1 0.2 0.4 -0.3 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.5 -0.7 0.1 0.5 0.4 0.1 0.0 0.3
Whole body fat-free mass 0.3 1.5 3.6 -0.6 -1.3 -0.5 -0.5 -1.9 -1.9 0.8
Leg fat-free mass (right) 0.2 1.3 3.4 -0.4 -1.1 -0.5 -0.6 -1.7 -1.9 0.9
Arm fat percentage (left) 0.6 2.5 6.5 1.2 2.1 -2.5 -0.9 -0.1 0.8 1.9
Average weekly red wine intake 0.7 1.0 2.5 -0.9 -1.0 1.6 1.3 0.7 0.5 0.2
Handedness (chirality/laterality): Left-handed 0.8 1.0 2.8 0.6 -0.1 -0.9 -0.9 -1.7 0.6 -1.4
Mood swings 2.1 3.9 8.5 2.9 2.5 -1.8 -2.7 -0.8 -0.1 1.2
Loneliness, isolation 1.3 1.8 4.3 0.7 0.2 -1.0 -1.4 -1.6 -1.6 2.1
Long-standing illness, disability or infirmity 0.7 1.1 3.7 0.4 0.0 1.9 -1.0 0.0 -1.1 1.3
Ever had bowel cancer screening 0.9 1.0 2.2 0.6 1.4 0.4 0.8 1.5 1.4 -0.3
Diabetes diagnosed by doctor 0.5 0.8 2.8 0.4 0.8 -1.3 -0.5 -0.1 -0.2 1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.1 -0.4 0.3 -1.0 0.9 1.1 0.9 -0.4
Friendships satisfaction 1.4 1.7 5.1 -0.1 0.2 -0.3 -1.0 -1.9 -1.4 2.2
Qualifications: nursing, teaching 0.3 0.4 1.6 0.0 -0.0 -0.5 -0.2 -1.0 0.3 -1.3
Commuting to job workplace: Walk 0.5 0.5 1.5 0.4 0.4 1.2 -0.3 0.4 0.1 1.1
Eye problems/disorders: Cataract 0.9 1.0 2.1 1.2 0.7 1.4 -0.5 1.4 0.8 0.4
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.8 1.1 0.5 0.9 -1.3 -0.3 -0.5 0.9
Medication for cholesterol 0.5 0.7 1.1 1.0 0.8 -0.7 -1.1 -0.8 0.9 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.8 0.5 0.1 0.6 -0.1 0.4 0.0 0.9
Back pain experienced in last month 0.3 0.4 1.3 0.5 0.5 -0.7 -0.7 -1.1 -0.4 -0.1
Mineral and other dietary supplements 1.7 2.3 5.1 -2.3 -1.5 -1.8 2.2 0.5 -0.4 -0.7
Breast cancer (self-reported) 0.7 0.9 2.2 -0.3 -0.2 1.5 -1.0 -0.2 -1.1 1.2
Asthma (self-reported) 0.7 1.3 4.0 -2.0 -0.6 1.0 -0.2 0.5 -1.4 1.3
Osteoporosis (self-reported) 2.9 3.6 10.2 3.2 2.7 -0.1 -1.8 0.9 1.8 -0.2
Osteoarthritis (self-reported) 1.0 1.3 3.6 1.8 1.9 0.5 -1.4 0.2 0.5 0.1
Medication: Aspirin 0.2 0.2 1.0 -0.3 -0.1 -1.0 0.2 -0.3 -0.0 0.5
Medication: Gliclazide 0.4 0.4 1.8 -0.3 0.3 -1.4 0.4 0.3 0.8 0.1
Illnesses of father: None of the above (group 1) 1.7 2.1 4.6 1.9 2.1 -0.8 -1.5 0.0 1.6 -1.1
Smoking status: Current 1.1 1.7 3.9 -2.0 -1.8 -0.5 0.5 -1.1 -1.3 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 4.8 2.2 0.8 1.3 -1.1 -0.5 0.6 -0.2
Whole body water mass 0.3 1.4 3.6 -0.5 -1.3 -0.4 -0.6 -1.9 -1.9 0.8
Leg predicted mass (right) 0.2 1.2 3.2 -0.4 -1.0 -0.5 -0.6 -1.7 -1.8 0.9
Arm fat mass (left) 0.5 2.0 4.8 0.8 1.5 -2.2 -1.0 -0.8 0.0 2.1
Number of self-reported non-cancer illnesses 0.4 0.6 1.4 0.4 1.2 -0.2 -0.2 1.1 -0.7 1.2
Average weekly champagne plus white wine intake 0.6 0.8 1.6 1.3 1.2 -0.9 -0.8 0.7 0.5 -0.0
Miserableness 1.4 2.4 5.2 1.8 1.4 0.9 -2.0 -0.5 -1.2 2.3
Guilty feelings 1.2 1.8 5.5 2.4 1.9 -0.7 -1.0 0.8 1.1 0.2
Wears glasses or contact lenses 1.5 1.7 7.7 1.1 0.2 2.8 -0.3 1.0 1.0 -1.0
Ever taken oral contraceptive pill 0.2 0.2 0.9 -0.2 -0.1 1.0 0.5 0.4 -0.3 0.2
Hearing aid user 0.5 0.6 1.8 -0.0 -0.2 0.8 -0.6 -0.9 -1.3 0.6
Mother’s age at death 0.5 0.7 2.5 0.7 0.4 1.6 -0.9 -0.3 0.3 -0.7
Financial situation satisfaction 3.6 4.5 12.4 1.6 0.6 0.1 -3.0 -1.8 -2.1 3.5
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.2 1.1 0.9 -1.5 -0.3 0.2 1.1 0.2
Commuting to job workplace: Public transport 2.0 2.3 6.1 1.9 1.4 1.5 0.1 1.3 2.5 -0.6
Eye problems/disorders: Glaucoma 1.6 1.9 5.5 1.5 1.8 0.1 0.0 1.3 2.3 -0.9
Medication: Blood pressure 0.3 0.7 1.6 -1.2 -0.8 -0.8 0.2 -0.1 -1.3 0.4
Pain type(s) experienced in last month: Hip pain 0.4 0.4 1.6 0.1 0.4 0.4 -0.3 -0.7 -0.7 1.3
Supplements: Fish oil (including cod liver oil) 2.1 2.8 7.0 2.6 1.9 1.5 -1.6 0.7 1.8 0.2
High cholesterol (Self-reported) 0.4 0.7 1.8 -0.6 -0.4 -1.4 1.0 1.0 0.2 -0.6
Medication: Bendroflumethiazide 0.3 0.5 1.9 -1.4 -0.4 -0.6 0.9 -0.1 -0.3 0.1
Medication: Paracetamol 0.6 0.9 1.8 0.7 0.7 -1.1 -1.3 -1.1 -0.6 0.7
Medication: Lisinopril 1.0 1.3 3.3 1.6 1.8 -0.5 -1.2 -0.0 0.4 1.2
Medication: Atorvastatin 0.6 0.7 1.8 0.1 -0.4 -1.3 0.6 0.5 -0.8 1.3
Illnesses of father: High blood pressure 0.2 0.2 0.6 0.6 0.8 -0.1 0.1 -0.3 0.1 0.7
Alcohol drinker status: Never 0.3 0.4 1.6 0.1 -0.1 0.4 0.8 -0.2 1.3 -0.5
Ever smoked 0.6 1.0 3.2 -1.1 -0.4 -0.8 -0.8 -1.0 -1.8 0.6
Basal metabolic rate 0.2 1.3 3.3 -0.4 -0.9 -0.7 -0.5 -1.8 -1.7 1.1
Leg fat percentage (left) 1.0 3.7 14.4 0.9 2.5 -3.8 -1.1 -1.0 0.7 1.4
Arm fat-free mass (left) 0.3 1.5 4.4 -0.5 -0.8 -1.1 -0.6 -2.1 -1.6 1.1
Number of operations (self-reported) 0.7 1.0 3.7 -0.8 0.1 -0.2 -0.3 0.3 -1.9 1.6
Average weekly beer plus cider intake 1.2 1.8 7.1 -0.4 -0.7 0.2 -1.0 -1.8 -2.7 0.8
Irritability 1.8 3.1 9.5 -0.4 -0.9 -1.2 -1.5 -2.2 -3.1 1.8
Risk taking 0.3 0.4 0.9 0.8 0.9 -0.3 0.3 0.5 1.0 -0.1
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.8 -0.9 -0.6 0.3 0.4 0.2 -0.8 0.6
Fractured/broken bones in last 5 years 0.9 1.2 2.6 0.4 -0.7 1.3 -0.8 -0.9 -1.4 1.6
Age started oral contraceptive pill 1.9 2.4 5.4 2.3 1.8 0.6 -0.6 1.9 1.9 0.1
Diastolic blood pressure, automated reading 0.6 1.8 6.2 1.5 2.5 -1.6 -0.8 -0.1 0.9 -0.1
Ever depressed for a whole week 0.5 0.6 3.3 -0.2 -0.0 0.2 -0.5 -0.0 -0.6 1.8
Unable to work because of sickness or disability 0.2 0.3 1.5 0.2 0.2 -0.2 -0.3 -1.2 -0.2 -0.2
Commuting to job workplace: Cycle 0.9 1.1 3.3 0.1 0.3 1.8 -1.1 -1.2 -0.5 1.1
Myopia 1.3 1.9 5.5 -1.3 -1.6 2.4 1.3 0.7 -0.4 1.2
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.4 -0.7 -0.8 1.1 1.0 -0.3 0.8 -1.5
Cholesterol lowering medication 0.6 0.8 2.0 -1.4 -1.4 0.4 0.7 -0.0 -1.1 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.3 0.2 0.9 0.5 1.0 1.5 1.3 -0.2
Pain experienced in last month 0.5 0.8 1.7 0.2 -0.0 1.3 0.9 1.1 1.2 0.6
Supplements: Calcium 0.6 0.7 2.1 0.3 -1.2 0.6 -0.6 -0.0 -1.4 -0.7
Basal cell carcinoma (self-reported) 0.7 0.9 2.9 0.3 0.1 1.7 0.9 1.0 1.1 -0.3
Heart attack/myocardial infarction (self-reported) 0.4 0.5 2.7 0.0 0.1 -1.6 0.6 0.3 0.6 0.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.7 0.2 0.6 0.6 0.8 1.3 0.5 -0.1
Heart disease (siblings) 0.5 0.7 1.9 1.4 0.3 0.5 -0.6 0.8 0.0 1.2
Alcohol drinker status: Previous 1.0 1.1 2.9 -1.2 -1.1 -0.5 -0.0 -1.2 -1.7 0.6
Pack years of smoking 1.1 1.7 9.6 0.5 0.3 -3.1 -0.3 0.2 -0.4 1.2
Impedance of whole body 1.0 4.9 14.8 2.1 2.3 1.3 0.5 2.6 3.8 -0.7
Leg fat mass (left) 0.6 2.3 9.2 0.3 1.3 -3.0 -0.8 -1.3 -0.1 1.5
Arm predicted mass (left) 0.3 1.4 4.7 -0.6 -0.9 -1.0 -0.5 -2.2 -1.6 0.7