Hub : Genes

PLXNB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Thyroid 0.042 0.024 0.0064 0.027 NA -0.001 NA 0.036 0.0034 NA 0.4200 NA 0.00083
2 TCGA Cervical Squamous Cell Carcinoma 0.041 0.031 0.0071 0.024 0.031 0.033 NA 0.021 0.0230 0.012 0.0092 NA 0.03000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.5 3.9 5.2 -1.6 2.3
Bipolar Disorder or Schizophrenia 3.3 8.1 8.8 -3.0 2.7
Depressed Affect (Nagel 2018) 4.3 9.0 15.2 -1.7 3.9
Depression (Nagel 2018) 3.4 5.2 6.0 -2.1 2.5
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.2 -0.4 0.0
Neuroticism (Nagel 2018) 3.3 7.7 11.3 -2.0 3.4
Schizophrenia (2018) 2.1 4.5 6.1 -2.5 1.7
Schizophrenia vs Biploar Disorder 0.4 0.5 1.0 -1.0 -0.2
Worry (Nagel 2018) 1.7 3.6 4.7 -2.2 1.6
Alzheimer’s Disease (in mother) 0.5 0.5 1.1 -1.0 0.1
Alzheimer’s Disease (in father) 0.4 0.4 0.6 0.4 -0.8
Alzheimer’s Disease (including proxy) 0.3 0.4 0.5 -0.7 -0.6
Crohns Disease (2017) 0.1 0.2 0.3 0.6 -0.2
Irritable Bowel Disease (IBD) 1.0 2.3 3.7 1.0 -1.9
Ulcerative Colitis (UC) 2.8 5.2 9.1 1.1 -3.0
Major Depression (MDD) 3.7 4.5 5.0 -2.0 2.2
Reaction Time 1.0 1.9 2.6 -1.1 1.6
Verbal and Numeric Reasoning (VNR) 0.6 1.4 1.5 -1.2 1.1
Breast Cancer 0.4 0.9 1.3 1.1 -0.7
Ovarian Cancer 0.1 0.1 0.2 -0.5 0.3
Prostate Cancer 3.0 4.2 6.2 -2.5 1.5
Age at First Birth 0.0 0.1 0.1 -0.2 -0.3
Bipolar Disorder (2011) 0.7 0.7 1.3 -0.2 1.1
Body Mass Index (BMI) (2010) 0.3 0.4 0.8 -0.1 0.9
Coronary Artery Disease (CAD) 1.5 1.8 3.3 -1.8 -0.5
Crohns Disease (2012) 0.3 0.4 0.8 -0.2 0.9
Mean Putamen Volume 3.1 3.6 4.2 2.0 -1.7
Fasting Glucose 2.9 3.4 4.5 -2.1 1.5
HbA1C 0.2 0.2 0.3 0.4 -0.5
HDL Cholesterol 0.9 1.5 2.9 1.7 -0.2
LDL Cholesterol 0.2 0.3 0.6 -0.3 -0.8
Lupus 0.1 0.1 0.1 0.4 0.2
Neuroticism (2016) 1.9 2.7 4.4 -1.0 2.1
Primary Biliary Cirrhosis 1.3 1.8 3.1 1.8 -0.7
Rheumatoid Arthritis 0.2 0.3 0.5 0.7 0.3
Schizophrenia (2014) 1.7 3.7 4.6 -2.1 1.7
Triglycerides 1.9 3.0 3.7 1.5 -1.9
Type 2 Diabetes (T2D) (2012) 2.6 3.0 3.0 -1.7 1.7
Ulcerative Colitis 0.9 1.3 2.6 0.2 -1.6
Blood Eosinophil Count 0.5 4.0 5.8 1.5 -2.4
Blood Platelet Count 0.7 8.0 9.4 3.1 -2.5
Blood Red Count 0.6 5.6 11.2 -3.4 0.2
Blood White Count 1.0 7.3 9.0 -3.0 2.4
Heel T-Score 0.5 3.9 6.5 -1.2 -2.5
BMI 0.2 1.3 2.2 -0.7 1.5
Height 0.2 4.8 5.3 2.3 -2.1
Waist Hip Ratio (WHR) 4.1 18.6 26.7 3.2 -5.2
Systolic Blood Pressure 3.3 16.6 33.2 -5.8 0.1
Smoking Status 0.6 1.4 2.4 0.7 1.5
Allergy or Eczema 0.6 1.5 2.4 0.7 1.6
Cardiovascular Disease 2.7 9.0 17.8 -4.2 0.3
Hypothyroidism (self reported) 7.0 16.1 20.2 -4.5 3.5
Respiratory disease 0.5 1.2 2.4 1.6 -0.2
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.2 -1.5 -0.7
Lung FEV1/FVC ratio 0.9 4.4 5.4 1.8 -2.3
Lung FVC 0.7 3.6 6.3 1.0 -2.5
Neuroticism 3.2 7.8 10.6 -2.2 3.3
Chronotype (morning person) 1.1 2.6 4.9 -2.2 -0.6
Hair Pigment 0.1 2.6 4.2 2.1 -1.0
Tanning 0.0 0.4 0.8 0.0 -0.9
Hand grip strength (left) 0.2 0.5 0.8 -0.9 0.5
Number of treatments/medications taken 1.3 2.4 4.4 -2.1 0.6
Average weekly spirits intake 2.0 2.5 5.0 2.2 -0.1
Sensitivity / hurt feelings 0.4 0.6 1.2 1.1 -0.3
Frequency of depressed mood in last 2 weeks 3.8 5.3 7.0 -1.9 2.6
Hearing difficulty/problems: Yes 0.5 0.8 1.5 1.2 -0.4
Relative age of first facial hair 0.1 0.2 0.3 -0.5 0.3
Other serious medical condition/disability diagnosed by doctor 1.7 2.3 3.6 -1.9 0.9
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.6 0.7 -0.8
Ever had hysterectomy (womb removed) 0.1 0.1 0.1 0.3 -0.2
Systolic blood pressure, automated reading 2.2 6.5 13.0 -3.6 0.3
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.4 -0.7 0.3
Angina 0.2 0.3 0.5 -0.3 -0.7
Medication for hormone replacement therapy 0.2 0.3 0.4 -0.7 0.3
Vitamin and mineral supplements 0.3 0.5 0.6 -0.8 -0.6
Supplements: Zinc 0.3 0.3 0.5 -0.7 0.2
Medication: Co-codamol 0.1 0.1 0.3 -0.5 0.1
Medication: Metformin 0.4 0.6 1.2 0.2 -1.1
Diabetes (father) 0.7 0.8 1.7 -0.1 -1.3
Diabetes (mother) 0.9 1.2 2.1 -1.5 0.5
Severe depression (siblings) 0.4 0.5 0.9 -1.0 0.1
Pack years adult smoking proportion 6.5 9.9 10.6 -3.3 3.0
Impedance of leg (right) 0.5 2.4 2.5 1.5 -1.6
Leg fat-free mass (left) 0.4 2.0 2.4 -1.3 1.5
Trunk fat percentage 0.1 0.3 0.4 0.4 0.6
Hand grip strength (right) 0.2 0.6 0.9 -0.9 0.6
Townsend deprivation index at recruitment 1.0 1.4 2.5 -1.6 0.6
Current tobacco smoking 0.6 0.9 1.7 0.4 1.3
Average weekly fortified wine intake 0.2 0.2 0.3 0.5 0.3
Maternal smoking around birth 0.4 0.5 0.5 0.7 -0.7
Fed-up feelings 2.6 4.7 7.5 -1.4 2.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.3 -1.2 0.5
Relative age voice broke 0.9 1.4 1.4 -1.2 1.2
Taking other prescription medications 2.1 3.2 4.5 -2.1 1.4
Age when periods started (menarche) 2.2 5.4 5.7 -2.4 2.3
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 3.6 0.6 -1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 2.9 -0.9 -1.7
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.0 -0.8 1.0
Qualifications: CSEs or equivalent 1.0 1.4 2.3 -1.5 0.6
Serious illness, injury or assault to yourself 2.5 3.0 5.1 -2.3 1.0
High blood pressure 2.7 7.5 14.7 -3.8 0.5
Hayfever, allergic rhinitis or eczema 1.0 2.2 4.3 0.1 2.1
Multivitamins +/- minerals 0.1 0.1 0.2 0.4 0.2
Stomach or abdominal pain in last month 0.4 0.5 0.6 -0.6 0.8
Supplements: Glucosamine 0.1 0.2 0.3 0.5 -0.3
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 4.3 -0.9 2.1
Medication: Atenolol 0.8 1.0 1.6 -1.3 -0.6
Medication: Levothyroxine sodium 3.0 5.0 6.8 -2.6 1.8
Sitting height 0.2 1.5 1.7 -1.1 1.3
Chronic bronchitis/emphysema (father) 0.3 0.4 0.7 0.4 0.8
High blood pressure (mother) 0.5 0.7 1.2 -1.1 -0.4
Body mass index (BMI) 0.1 0.6 0.8 -0.6 0.9
Impedance of leg (left) 0.6 2.8 3.3 1.5 -1.8
Leg predicted mass (left) 0.3 1.8 2.2 -1.2 1.5
Trunk fat mass 0.1 0.3 0.7 0.0 0.8
Waist circumference 0.2 0.8 1.2 0.6 -1.1
Number of incorrect matches in round 4.5 7.5 10.0 -2.2 3.2
Past tobacco smoking 0.8 1.5 2.9 -1.7 0.2
Alcohol usually taken with meals 0.0 0.0 0.1 -0.3 -0.0
Nervous feelings 0.5 0.9 1.7 -1.3 0.4
Frequency of tenseness / restlessness in last 2 weeks 4.7 7.3 7.9 -2.6 2.8
Hearing difficulty/problems with background noise 0.2 0.3 0.6 0.8 0.2
Hair/balding pattern: Pattern 2 1.1 1.4 1.6 1.1 -1.3
Had menopause 0.6 0.8 1.2 1.1 -0.5
Had other major operations 0.1 0.1 0.1 0.3 0.3
Forced vital capacity (FVC) 0.4 1.4 2.5 0.5 -1.6
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 4.8 -0.8 -2.2
Ever unenthusiastic/disinterested for a whole week 2.0 2.5 4.2 -0.9 2.0
Qualifications: None of the above 0.3 0.6 1.2 1.1 0.2
Financial difficulties in last 2 years 0.2 0.2 0.3 0.4 -0.5
Mouth/teeth dental problems 1.9 3.0 4.5 -2.1 1.2
Heart attack 1.9 2.4 4.7 -2.2 0.5
Allergy 1.0 2.4 3.1 -1.8 -1.3
Pain all over the body in last month 4.7 5.1 5.6 -2.4 2.1
Diabetes (self-reported) 1.4 2.1 4.2 0.1 -2.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.3 0.7 -0.1 0.8
Medication: Ramipril 0.3 0.3 0.6 -0.8 0.2
Medication: Simvastatin 0.9 1.3 2.1 -0.7 -1.4
Fluid intelligence score 2.4 5.0 5.9 -2.0 2.4
Illnesses of siblings 2.7 3.8 7.3 2.7 -0.5
Neuroticism score 1.5 3.2 4.8 -1.2 2.2
Weight 0.1 0.6 0.8 -0.7 0.9
Impedance of arm (right) 0.6 2.9 3.8 2.0 -1.4
Arm fat percentage (right) 0.2 0.7 1.4 -0.1 1.2
Trunk fat-free mass 0.3 2.0 2.5 -1.6 1.2
Hip circumference 0.4 1.6 2.9 -0.6 1.7
Time employed in main current job 0.1 0.2 0.2 -0.4 -0.4
Alcohol intake versus 10 years previously 0.2 0.2 0.4 -0.3 -0.6
Father’s age at death 2.3 3.0 3.6 1.9 -1.6
Worrier / anxious feelings 3.3 6.2 9.0 -3.0 1.9
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 3.1 -1.3 1.8
Falls in the last year 3.1 4.2 5.4 1.7 -2.3
Hair/balding pattern: Pattern 3 0.1 0.2 0.3 0.3 -0.5
Number of live births 0.3 0.4 0.7 0.8 -0.4
Forced expiratory volume in 1-second (FEV1) 1.1 3.7 6.2 1.1 -2.5
Pulse rate 2.3 3.8 6.7 1.0 -2.6
Happiness 1.8 2.1 2.6 -1.6 1.3
Noisy workplace 0.0 0.0 0.1 -0.2 0.2
Qualifications: A levels/AS levels or equivalent 0.6 1.4 1.7 -1.0 1.3
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.1 -0.5 1.4
Mouth/teeth dental problems: Dentures 0.4 0.7 1.0 1.0 -0.6
Asthma 0.8 1.5 3.1 1.8 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.9 0.4 0.9
Medication: Cholesterol lowering 0.8 1.3 1.9 -1.4 -0.8
Depression (self-reported) 0.4 0.4 0.9 0.9 0.0
Medication: Lansoprazole 1.8 2.1 4.0 -2.0 0.4
Prospective memory result 0.2 0.3 0.4 0.6 -0.4
Lung cancer (father) 2.0 2.3 4.3 -0.5 2.1
Illnesses of mother 0.4 0.4 0.8 0.2 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.2 6.7 1.3 -2.6
Pulse wave Arterial Stiffness index 0.0 0.1 0.1 0.1 -0.3
Impedance of arm (left) 0.8 3.8 5.2 2.3 -1.5
Arm fat mass (right) 0.2 0.6 1.1 -0.3 1.1
Trunk predicted mass 0.4 2.2 2.7 -1.6 1.3
Standing height 0.0 0.0 0.0 -0.1 -0.1
Length of working week for main job 0.1 0.2 0.3 0.5 -0.2
Exposure to tobacco smoke at home 3.5 4.0 6.2 -2.5 1.3
Breastfed as a baby 0.2 0.3 0.5 0.7 -0.1
Tense / ‘highly strung’ 4.3 7.1 7.8 -2.8 2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.2 0.5 -0.1 0.7
Hair/balding pattern: Pattern 4 0.2 0.5 0.9 0.1 0.9
Birth weight of first child 4.0 7.2 9.5 3.1 -2.2
Peak expiratory flow (PEF) 0.2 0.5 0.6 -0.7 -0.8
Pulse wave reflection index 0.1 0.1 0.2 -0.1 0.4
Ever highly irritable/argumentative for 2 days 1.4 1.6 2.4 -0.9 1.6
Loud music exposure frequency 0.3 0.3 0.4 -0.6 -0.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.2 -1.1 0.5
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.3 1.1 -0.1
Blood clot in the leg (DVT) 0.2 0.3 0.4 0.6 -0.4
Medication: Paracetamol 1.5 2.5 4.7 0.5 2.2
Headache pain in last month 0.8 1.4 2.5 1.6 -0.4
Medication for cholesterol, blood pressure or diabetes 1.7 2.8 4.6 2.2 1.0
Glaucoma (self-reported) 0.9 1.1 2.2 -1.5 0.0
Gout (self-reported) 0.2 0.3 0.6 -0.3 -0.7
Hypothyroidism/myxoedema (self-reported) 3.8 7.4 10.3 -3.2 2.1
Medication: Amlodipine 0.9 1.3 1.9 -0.9 -1.4
Medication: Ventolin 100micrograms inhaler 0.0 0.0 0.1 -0.2 -0.1
Birth weight 0.4 0.9 1.5 1.2 0.5
Chronic bronchitis/emphysema (mother) 1.3 1.5 2.0 1.0 -1.4
High blood pressure (siblings) 1.1 1.6 3.2 -1.8 -0.3
Forced vital capacity (FVC), Best measure 0.7 2.6 3.9 1.1 -2.0
Body fat percentage 0.1 0.3 0.5 0.1 0.7
Leg fat percentage (right) 0.0 0.2 0.3 -0.2 0.5
Arm fat-free mass (right) 0.4 2.0 2.1 -1.5 1.4
Exposure to tobacco smoke outside home 0.7 0.9 1.7 -1.3 0.3
Comparative body size at age 10 1.5 4.2 8.1 2.9 -0.4
Number of full brothers 1.0 1.2 2.4 0.3 1.6
Worry too long after embarrassment 0.3 0.5 0.8 0.9 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.8 -0.0 1.3
Wheeze or whistling in the chest in last year 0.7 1.3 2.6 1.6 -0.0
Number of children fathered 0.0 0.1 0.1 -0.3 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.5 -1.2 0.7
Age at first live birth 0.1 0.1 0.2 0.4 -0.0
Pulse wave peak to peak time 0.2 0.2 0.3 -0.4 0.6
Health satisfaction 1.1 1.4 1.9 -1.4 1.0
Shortness of breath walking on level ground 0.6 0.8 0.8 0.9 -0.9
Qualifications: College or University degree 1.5 4.8 8.3 -2.9 1.1
Eye problems/disorders: None of the above 0.4 0.4 0.6 0.7 0.5
Mouth/teeth dental problems: Loose teeth 4.6 5.5 6.0 2.2 -2.5
Emphysema/chronic bronchitis 3.5 3.9 6.8 2.6 -1.0
Medication for pain relief, constipation, heartburn 0.3 0.6 1.1 -0.2 -1.0
Neck or shoulder pain in last month 0.0 0.0 0.1 0.3 0.1
Medication: Blood pressure 2.8 4.9 9.5 -3.1 -0.5
Angina (self-reported) 0.2 0.3 0.5 -0.4 -0.7
Migraine (self-reported) 3.3 4.1 5.5 2.4 -1.6
Medication: Ibuprofen 0.5 0.6 1.2 0.1 1.1
Medication: Allopurinol 0.5 0.6 0.8 -0.9 -0.7
Medication: Omeprazole 0.5 0.6 0.7 0.7 -0.8
Medication: Seretide 50 evohaler 0.3 0.3 0.5 -0.4 0.7
Mean time to correctly identify matches 0.8 1.5 2.1 -1.0 1.4
Heart disease (mother) 0.2 0.2 0.5 0.0 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.6 3.0 3.8 1.5 -1.9
Whole body fat mass 0.1 0.5 0.9 -0.3 0.9
Leg fat mass (right) 0.1 0.4 0.6 -0.3 0.8
Arm predicted mass (right) 0.4 2.2 2.6 -1.6 1.4
Pulse rate, automated reading 1.4 4.6 9.2 0.2 -3.0
Alcohol intake frequency. 0.3 0.6 0.8 -0.7 -0.9
Comparative height size at age 10 0.1 0.4 0.8 0.9 0.0
Number of full sisters 0.1 0.1 0.2 0.2 -0.5
Suffer from ‘nerves’ 0.4 0.7 1.1 -0.5 1.0
Overall health rating 0.2 0.4 0.4 -0.7 0.5
Chest pain or discomfort 0.1 0.2 0.4 0.1 0.6
Had major operations 5.5 6.5 8.2 -2.9 2.2
Age at last live birth 0.3 0.4 0.8 0.2 0.9
Family relationship satisfaction 4.6 5.7 7.0 -2.1 2.6
Leg pain on walking 0.9 1.1 1.3 0.9 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.1 0.1 -0.3
Commuting to job workplace: Car/motor vehicle 5.8 6.7 11.3 3.4 -1.4
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.0 1.4 -0.7
Medication: Aspirin 1.4 1.9 2.6 -1.1 -1.6
Supplements: Vitamin C 1.0 1.2 1.7 1.3 -0.8
Knee pain experienced in last month 4.0 6.3 7.6 2.2 -2.8
Hypertension (Self-reported) 2.7 7.6 15.1 -3.9 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.4 3.0 1.4 -1.7
Illnesses of father: Heart disease 0.6 0.9 1.6 -0.3 -1.3
Illnesses of siblings: Diabetes 2.3 2.8 3.3 -1.5 1.8
Smoking status: Previous 1.3 1.9 2.7 1.7 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 1.0 -0.3 1.0
Whole body fat-free mass 0.4 2.2 2.4 -1.6 1.4
Leg fat-free mass (right) 0.3 1.7 1.9 -1.3 1.4
Arm fat percentage (left) 0.1 0.4 0.9 0.1 0.9
Average weekly red wine intake 0.0 0.0 0.0 -0.1 -0.2
Handedness (chirality/laterality): Left-handed 0.9 1.1 2.2 -1.5 0.0
Mood swings 3.1 5.6 6.7 -2.1 2.6
Loneliness, isolation 2.8 3.9 4.1 -1.9 2.0
Long-standing illness, disability or infirmity 0.4 0.6 1.1 -0.2 -1.1
Ever had bowel cancer screening 0.1 0.1 0.1 0.4 0.2
Diabetes diagnosed by doctor 0.6 1.0 1.7 -0.6 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 2.5 2.6 2.7 1.6 -1.6
Friendships satisfaction 5.0 6.2 7.1 -2.3 2.7
Qualifications: nursing, teaching 3.1 4.8 6.0 -1.9 2.5
Commuting to job workplace: Walk 4.6 5.0 6.7 -2.6 1.8
Eye problems/disorders: Cataract 0.3 0.3 0.6 -0.8 -0.1
Mouth/teeth dental problems: Mouth ulcers 2.9 4.7 5.6 2.4 -1.9
Medication for cholesterol 1.0 1.5 1.6 1.2 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 2.4 -0.6 1.6
Back pain experienced in last month 2.1 3.0 5.3 2.3 -0.9
Mineral and other dietary supplements 0.1 0.2 0.3 0.1 0.6
Breast cancer (self-reported) 0.1 0.1 0.2 0.2 -0.5
Asthma (self-reported) 1.0 2.0 4.0 2.0 -0.2
Osteoporosis (self-reported) 6.0 7.5 9.7 -2.3 3.1
Osteoarthritis (self-reported) 0.1 0.2 0.3 -0.3 -0.5
Medication: Aspirin 1.0 1.3 1.7 -1.0 -1.3
Medication: Gliclazide 0.0 0.0 0.1 -0.3 0.0
Illnesses of father: None of the above (group 1) 1.0 1.2 2.1 1.4 0.5
Smoking status: Current 0.7 1.1 2.2 0.1 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 2.6 0.7 -1.6
Whole body water mass 0.4 2.3 2.5 -1.6 1.4
Leg predicted mass (right) 0.3 1.7 1.9 -1.2 1.4
Arm fat mass (left) 0.1 0.5 1.0 -0.2 1.0
Number of self-reported non-cancer illnesses 1.1 1.9 3.2 -1.8 0.7
Average weekly champagne plus white wine intake 0.3 0.5 0.8 -0.3 0.9
Miserableness 4.4 7.7 11.4 -2.0 3.4
Guilty feelings 0.7 1.0 2.0 1.4 0.0
Wears glasses or contact lenses 1.6 1.9 2.2 -1.2 1.5
Ever taken oral contraceptive pill 1.3 1.4 1.5 -1.2 1.2
Hearing aid user 0.1 0.1 0.2 0.3 -0.4
Mother’s age at death 0.3 0.4 0.6 0.8 -0.5
Financial situation satisfaction 1.0 1.3 1.6 -1.0 1.3
Tinnitus: Yes, now most or all of the time 1.0 1.1 2.3 -0.2 -1.5
Commuting to job workplace: Public transport 2.8 3.3 6.0 -2.5 0.7
Eye problems/disorders: Glaucoma 0.8 0.9 1.7 -1.3 -0.2
Medication: Blood pressure 1.6 3.1 5.0 -2.2 -1.1
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 0.5 -0.0
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.6 -0.4 -0.8
High cholesterol (Self-reported) 1.0 1.8 3.5 0.1 -1.9
Medication: Bendroflumethiazide 1.2 1.8 3.5 -1.9 -0.1
Medication: Paracetamol 2.6 4.0 7.8 -0.4 2.8
Medication: Lisinopril 2.7 3.5 6.8 -2.6 -0.5
Medication: Atorvastatin 0.1 0.1 0.2 -0.0 -0.4
Illnesses of father: High blood pressure 1.5 1.8 2.0 -1.4 -1.3
Alcohol drinker status: Never 1.4 1.7 1.9 1.2 -1.4
Ever smoked 0.9 1.5 2.1 1.4 1.0
Basal metabolic rate 0.3 1.9 1.9 -1.4 1.4
Leg fat percentage (left) 0.0 0.1 0.2 -0.1 0.4
Arm fat-free mass (left) 0.8 4.1 4.8 -2.2 1.8
Number of operations (self-reported) 0.7 1.1 1.2 -1.0 1.1
Average weekly beer plus cider intake 0.4 0.6 1.2 -0.1 1.1
Irritability 4.2 7.2 9.0 -2.3 3.0
Risk taking 1.0 1.4 1.5 1.1 -1.2
Ever had prostate specific antigen (PSA) test 1.4 1.6 1.9 1.1 -1.4
Fractured/broken bones in last 5 years 0.5 0.6 1.0 -1.0 0.5
Age started oral contraceptive pill 0.0 0.0 0.0 0.2 0.1
Diastolic blood pressure, automated reading 3.2 9.9 19.5 -4.4 0.5
Ever depressed for a whole week 0.6 0.8 1.1 -0.7 1.1
Unable to work because of sickness or disability 0.5 0.6 1.0 0.5 -1.0
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.0 0.4
Myopia 2.5 3.7 3.9 -2.0 1.9
Vascular/heart problems diagnosed by doctor 3.9 10.6 20.2 4.5 -1.0
Cholesterol lowering medication 0.6 0.8 1.6 0.2 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.3 0.5 -0.3
Pain experienced in last month 0.2 0.3 0.4 -0.7 0.4
Supplements: Calcium 0.3 0.3 0.6 0.7 0.2
Basal cell carcinoma (self-reported) 0.5 0.6 1.2 -0.2 1.1
Heart attack/myocardial infarction (self-reported) 1.8 2.3 4.5 -2.1 0.5
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.0 0.1 -0.0
Heart disease (siblings) 2.1 2.6 4.1 -2.0 1.0
Alcohol drinker status: Previous 0.3 0.4 0.8 0.1 -0.9
Pack years of smoking 5.1 7.5 8.8 -3.0 2.5
Impedance of whole body 0.9 4.4 5.2 2.3 -1.9
Leg fat mass (left) 0.1 0.4 0.7 -0.4 0.8
Arm predicted mass (left) 0.3 1.8 2.1 -1.5 1.2