Hub : Genes

PM20D2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1469 0.0435 1.3e-05 0.068 NA 0.085 NA 0.060 5.3e-06 NA 3.3e-07 NA 1.7e-05
2 GTEx Cells EBV-transformed lymphocytes 0.3900 0.0830 5.0e-08 0.268 NA 0.229 NA 0.278 2.6e-09 NA 5.1e-08 NA 1.2e-09
3 GTEx Esophagus Mucosa 0.1480 0.0540 1.5e-03 0.028 NA 0.020 NA 0.030 5.2e-03 NA 1.5e-02 NA 4.4e-03
4 GTEx Heart Atrial Appendage 0.1000 0.0450 9.4e-03 -0.002 NA -0.006 NA 0.037 4.0e-01 NA 7.5e-01 NA 8.9e-03
5 GTEx Lung 0.0888 0.0428 1.0e-02 -0.002 NA 0.005 NA -0.004 5.1e-01 NA 1.2e-01 NA 8.7e-01
6 GTEx Ovary 0.2280 0.1020 5.9e-03 0.019 NA 0.148 NA 0.077 1.1e-01 NA 1.8e-04 NA 6.1e-03
7 YFS Blood 0.0386 0.0133 3.0e-05 0.007 0.02 0.021 0.021 0.013 1.6e-03 3.4e-07 1.0e-07 1.8e-07 2.2e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.6 2.6 5.6 -0.4 -2.4 0.7 2.3 -0.0 2.0 1.6
Bipolar Disorder or Schizophrenia 1.1 2.8 7.0 -1.3 -2.6 0.9 2.6 -1.0 1.0 -1.1
Depressed Affect (Nagel 2018) 1.3 2.7 4.8 -0.2 2.0 0.7 -2.0 -2.2 -2.2 0.9
Depression (Nagel 2018) 1.1 1.7 4.6 1.1 1.2 1.4 -1.2 -1.1 -2.1 -0.4
Intelligence (Savage-Jansen 2018) 0.4 1.1 4.1 0.3 -0.6 1.1 0.6 2.0 1.2 -0.1
Neuroticism (Nagel 2018) 1.2 2.9 7.1 0.2 2.5 1.0 -2.5 -0.4 -2.7 -0.1
Schizophrenia (2018) 1.3 2.7 10.7 -1.4 -1.5 0.6 1.6 -1.1 -0.4 -3.3
Schizophrenia vs Biploar Disorder 2.6 3.4 5.9 -0.0 2.4 -1.4 -2.3 -1.7 -1.6 -2.3
Worry (Nagel 2018) 0.9 1.8 3.6 0.6 1.6 1.9 -1.6 1.1 -1.4 -0.6
Alzheimer’s Disease (in mother) 0.4 0.5 1.5 -0.1 -0.8 -1.2 0.8 0.4 -0.5 -0.0
Alzheimer’s Disease (in father) 0.8 0.8 3.6 -0.8 -0.7 -0.4 0.7 -0.5 0.3 1.9
Alzheimer’s Disease (including proxy) 0.5 0.8 2.2 -0.5 -0.9 -1.5 0.8 -0.7 -0.3 0.8
Crohns Disease (2017) 1.1 2.5 8.1 -0.9 0.9 -1.1 -1.0 -2.8 -1.1 2.1
Irritable Bowel Disease (IBD) 0.7 1.6 5.7 -0.6 -0.2 -0.8 0.2 -2.4 -0.8 2.0
Ulcerative Colitis (UC) 0.5 1.0 2.6 -0.4 -1.0 -0.5 1.0 -1.4 -0.3 1.6
Major Depression (MDD) 1.4 1.7 3.8 -1.4 1.4 -0.3 -1.3 -1.5 -2.0 0.2
Reaction Time 0.3 0.6 3.1 -0.0 0.3 -0.5 -0.4 0.2 -0.8 -1.8
Verbal and Numeric Reasoning (VNR) 0.7 1.6 3.8 1.6 0.2 2.0 -0.2 1.9 0.5 -0.9
Breast Cancer 0.9 2.2 4.4 2.1 0.5 2.1 -0.4 1.4 0.5 2.1
Ovarian Cancer 0.9 1.2 2.9 0.4 1.6 0.7 -1.4 -1.7 -0.8 0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.1 1.5 5.4 1.9 -0.1 1.2 -0.2 2.3 0.2 -0.0
Bipolar Disorder (2011) 0.8 0.7 1.7 -0.5 -1.3 0.4 1.3 0.7 0.5 0.8
Body Mass Index (BMI) (2010) 0.2 0.3 1.2 0.1 0.4 -0.3 -0.5 1.1 -0.5 0.2
Coronary Artery Disease (CAD) 0.4 0.5 3.1 0.0 0.2 -0.2 -0.4 0.1 0.1 -1.8
Crohns Disease (2012) 1.5 2.4 6.9 -1.0 0.8 0.8 -0.7 -2.2 -1.6 2.6
Mean Putamen Volume 0.4 0.4 0.9 -0.4 0.7 -0.6 -0.7 -0.8 -0.9 0.1
Fasting Glucose 0.3 0.3 1.6 -1.3 0.2 -0.1 -0.2 0.2 -0.6 -0.6
HbA1C 0.5 0.5 1.0 0.5 0.8 0.5 -0.9 -0.4 -1.0 0.8
HDL Cholesterol 0.6 1.0 2.2 0.8 1.4 0.9 -1.5 -0.0 -0.5 1.2
LDL Cholesterol 0.1 0.1 0.3 -0.0 0.2 0.3 -0.2 0.4 0.5 -0.3
Lupus 0.5 0.7 1.3 1.1 1.0 0.7 -0.9 1.1 0.2 0.5
Neuroticism (2016) 1.0 1.4 2.4 0.8 1.4 1.5 -1.5 1.5 -0.6 -0.2
Primary Biliary Cirrhosis 0.9 1.4 4.1 1.1 -0.8 2.0 0.8 1.4 0.7 -0.7
Rheumatoid Arthritis 1.1 1.5 4.0 1.2 0.3 0.1 -0.3 1.4 2.0 1.7
Schizophrenia (2014) 0.8 1.7 7.1 -0.7 -0.8 0.5 0.9 -1.6 0.2 -2.7
Triglycerides 0.6 1.0 2.3 -0.4 -1.5 0.0 1.5 1.1 1.1 -0.5
Type 2 Diabetes (T2D) (2012) 1.2 1.4 4.1 0.8 1.6 0.6 -2.0 0.2 -1.3 -0.4
Ulcerative Colitis 0.7 1.0 1.9 -0.7 -1.2 0.2 1.2 -1.1 -0.8 1.4
Blood Eosinophil Count 0.4 2.9 7.2 1.9 -2.0 -0.3 1.6 0.7 2.7 1.4
Blood Platelet Count 0.3 3.0 6.0 -2.5 -2.1 -1.1 2.1 -2.0 0.4 -1.0
Blood Red Count 0.1 0.6 2.2 -1.5 0.3 -0.0 -0.3 -0.5 -0.9 0.7
Blood White Count 0.4 2.8 7.7 -2.8 -1.9 -1.2 1.8 -1.5 1.0 0.8
Heel T-Score 0.2 1.5 2.6 0.7 1.1 -0.6 -1.1 1.6 -1.6 1.5
BMI 0.4 2.3 4.7 -0.5 -1.8 -1.8 1.7 1.4 2.2 0.5
Height 0.4 8.6 31.8 2.0 0.9 4.0 -0.7 5.6 0.6 2.6
Waist Hip Ratio (WHR) 0.5 2.3 4.3 -0.4 -1.9 1.7 2.1 -0.5 1.8 -1.4
Systolic Blood Pressure 0.1 0.6 4.2 -0.3 0.1 -2.0 0.1 -0.2 -0.4 0.0
Smoking Status 0.2 0.4 1.1 1.1 0.7 0.4 -0.6 -0.3 0.7 0.5
Allergy or Eczema 0.1 0.1 0.5 -0.5 -0.2 0.7 0.2 -0.0 -0.5 -0.0
Cardiovascular Disease 0.3 0.9 1.9 1.3 0.4 0.9 -0.4 1.2 0.1 1.4
Hypothyroidism (self reported) 2.1 4.8 8.6 2.6 2.5 2.1 -2.5 2.9 -0.3 -1.1
Respiratory disease 0.3 0.6 1.1 -0.9 0.1 -0.9 -0.4 -1.0 -0.7 0.9
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.2 0.1 -0.8 0.1 0.9 -1.0 1.1 0.2
Lung FEV1/FVC ratio 0.2 1.1 3.2 -1.4 -0.5 -0.7 0.6 -1.3 -0.2 1.8
Lung FVC 0.1 0.4 1.2 1.1 0.8 -0.0 -0.9 0.2 -0.2 0.4
Neuroticism 1.4 3.4 8.0 -0.1 2.4 1.9 -2.5 -0.8 -2.8 0.0
Chronotype (morning person) 1.5 3.6 9.1 1.0 2.3 1.1 -2.1 0.0 -3.0 2.0
Hair Pigment 0.0 1.2 2.6 0.8 1.3 -0.5 -1.2 -0.8 -1.0 1.6
Tanning 0.2 1.9 6.0 -0.5 -2.4 -0.8 2.5 -0.4 0.7 -0.4
Hand grip strength (left) 1.1 2.8 7.6 1.9 0.3 2.4 -0.3 2.8 -0.3 -1.6
Number of treatments/medications taken 0.4 0.7 3.3 0.1 0.4 0.2 -0.5 -0.4 -1.1 1.8
Average weekly spirits intake 0.4 0.5 1.8 -0.6 -0.5 0.3 0.5 0.2 0.9 -1.3
Sensitivity / hurt feelings 0.3 0.6 2.1 -0.2 0.1 1.4 -0.1 1.1 -0.7 0.1
Frequency of depressed mood in last 2 weeks 0.6 0.9 2.8 -0.2 0.2 1.4 -0.2 -1.1 -1.7 0.4
Hearing difficulty/problems: Yes 3.1 4.7 8.2 2.9 2.9 2.3 -2.8 1.4 -1.2 -0.4
Relative age of first facial hair 0.4 0.9 3.4 0.5 -0.2 1.9 0.3 -1.5 0.1 -0.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 3.2 1.0 1.0 1.8 -0.9 0.8 -0.5 0.9
Ever used hormone-replacement therapy (HRT) 1.3 1.7 3.2 0.8 1.6 1.8 -1.4 -0.6 -1.4 -1.2
Ever had hysterectomy (womb removed) 0.3 0.3 1.3 -0.6 -0.4 -0.6 0.4 -0.1 -0.0 -1.1
Systolic blood pressure, automated reading 0.6 1.8 9.7 -1.5 -0.3 -3.1 0.3 -0.3 -0.8 0.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 1.8 -1.3 -1.3 -0.4 1.4 -0.1 -0.3 0.4
Angina 0.7 0.9 3.3 -0.7 0.5 -1.2 -0.4 -1.8 -0.7 0.4
Medication for hormone replacement therapy 0.8 0.9 3.5 -0.4 -0.4 0.8 0.5 -0.9 0.8 -1.9
Vitamin and mineral supplements 0.8 1.1 3.9 0.7 -1.2 0.2 1.1 0.4 2.0 -0.6
Supplements: Zinc 1.1 1.2 4.7 -0.4 0.7 -0.7 -0.8 -0.7 -2.2 1.1
Medication: Co-codamol 0.5 0.6 2.2 1.5 -0.4 -0.6 0.2 1.1 0.1 0.1
Medication: Metformin 0.1 0.2 0.4 0.6 -0.1 0.4 0.1 0.5 0.5 -0.4
Diabetes (father) 1.1 1.3 3.1 -1.6 -1.8 -0.6 1.6 0.0 0.6 -0.3
Diabetes (mother) 1.1 1.4 5.4 -0.1 -0.8 -1.4 0.7 -1.2 2.3 -0.5
Severe depression (siblings) 0.8 0.9 3.6 0.8 0.1 0.4 -0.2 1.2 -1.9 0.8
Pack years adult smoking proportion 0.6 1.0 2.7 -0.2 -1.3 -0.6 1.1 -0.7 1.6 -0.6
Impedance of leg (right) 0.2 0.8 2.2 -0.2 0.7 1.5 -0.4 -1.3 -0.4 1.1
Leg fat-free mass (left) 0.5 2.9 14.9 1.5 -0.8 0.2 0.7 3.9 1.3 -0.2
Trunk fat percentage 0.6 2.6 4.2 -1.6 -2.0 -1.7 1.9 0.4 2.0 1.0
Hand grip strength (right) 1.4 3.7 9.9 2.3 0.9 3.1 -0.9 2.3 -0.2 -1.9
Townsend deprivation index at recruitment 1.0 1.3 2.1 -1.4 -1.4 -0.9 1.3 -1.0 1.5 0.1
Current tobacco smoking 0.6 1.0 4.3 2.1 0.0 0.5 -0.1 -1.2 1.0 -0.0
Average weekly fortified wine intake 0.4 0.5 1.1 -0.0 -0.8 0.2 0.8 -0.0 1.0 -0.9
Maternal smoking around birth 1.2 1.8 3.0 0.1 -1.6 -1.0 1.5 -1.4 1.7 -1.2
Fed-up feelings 0.8 1.4 3.2 -1.0 1.2 -0.6 -1.1 -1.7 -1.8 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 4.6 -1.0 -0.5 -0.1 0.7 -2.1 -1.8 0.4
Relative age voice broke 0.7 1.1 3.4 0.9 0.5 1.8 -0.5 1.2 -1.0 -0.8
Taking other prescription medications 0.5 0.8 2.2 -0.5 0.6 0.7 -0.5 -0.4 -1.4 1.5
Age when periods started (menarche) 0.9 2.3 8.8 0.8 -0.5 3.0 0.6 2.3 0.7 0.3
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.5 -0.9 -1.5 -0.6 1.6 -0.6 -0.3 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 11.0 0.6 -0.5 0.4 0.4 3.3 0.6 -1.5
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 -0.4 -0.3 -0.6 0.3 -0.2 0.1 -0.2
Qualifications: CSEs or equivalent 0.3 0.4 1.9 0.1 0.2 -0.7 -0.1 -0.4 -0.0 1.4
Serious illness, injury or assault to yourself 0.6 0.8 1.6 0.6 0.4 1.3 -0.4 -1.1 1.0 1.0
High blood pressure 0.6 1.5 2.4 1.1 1.3 -0.2 -1.4 1.4 -1.6 1.2
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.2 -0.1 -0.9 1.1 0.8 -0.3 -0.2 -0.2
Multivitamins +/- minerals 0.6 0.8 1.8 -0.0 1.3 -0.2 -1.3 0.7 -1.3 0.3
Stomach or abdominal pain in last month 0.7 0.8 2.6 1.6 0.6 1.6 -0.5 0.0 0.3 0.1
Supplements: Glucosamine 0.4 0.6 1.4 -0.1 0.3 -1.1 -0.3 0.2 -1.1 1.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.4 -1.2 0.2 -0.2 -0.0 -0.7 0.7 0.3
Medication: Atenolol 1.0 1.3 6.6 -0.3 0.4 -2.6 -0.3 -0.0 -0.7 1.2
Medication: Levothyroxine sodium 0.4 0.8 1.6 0.4 0.9 0.8 -0.9 -0.4 1.3 -1.0
Sitting height 0.6 4.0 17.1 1.8 -0.7 0.4 0.8 4.1 2.3 0.9
Chronic bronchitis/emphysema (father) 0.8 1.0 2.6 0.7 -0.8 1.6 0.7 -0.1 1.6 0.3
High blood pressure (mother) 0.3 0.4 1.1 0.5 -0.1 -0.9 0.2 0.6 1.0 0.0
Body mass index (BMI) 0.6 2.7 6.4 -1.4 -1.9 -2.5 1.8 0.5 1.9 0.4
Impedance of leg (left) 0.3 1.3 3.8 -0.7 0.8 1.4 -0.6 -2.0 -0.7 1.1
Leg predicted mass (left) 0.5 2.9 14.9 1.6 -0.8 0.2 0.7 3.9 1.3 -0.2
Trunk fat mass 0.6 2.8 4.9 -1.1 -2.1 -1.5 2.0 1.4 2.2 0.9
Waist circumference 1.1 3.9 9.2 -1.0 -2.7 -1.3 2.6 1.2 3.0 0.2
Number of incorrect matches in round 0.5 0.8 1.9 0.5 0.6 1.4 -0.7 -0.8 -1.0 -1.0
Past tobacco smoking 0.8 1.6 2.4 -0.6 -1.4 -1.5 1.3 -1.3 1.2 -1.1
Alcohol usually taken with meals 2.2 3.6 8.2 2.0 2.9 1.6 -2.7 1.4 -0.5 0.9
Nervous feelings 1.3 2.5 5.1 0.5 2.2 1.3 -2.2 0.9 -2.3 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 4.0 1.2 1.3 0.5 -1.4 -0.0 -2.0 -0.9
Hearing difficulty/problems with background noise 2.6 4.1 6.3 1.9 2.3 2.5 -2.3 2.1 -1.8 -0.6
Hair/balding pattern: Pattern 2 0.2 0.2 1.3 -0.3 0.1 1.2 -0.0 0.3 -0.3 -0.2
Had menopause 0.6 0.8 1.7 -0.2 1.1 0.3 -1.0 1.0 -0.6 1.3
Had other major operations 0.9 1.1 2.3 0.4 -1.3 0.5 1.4 0.7 1.5 -1.0
Forced vital capacity (FVC) 0.9 3.4 11.3 2.1 0.3 2.4 -0.3 3.4 1.1 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 6.2 0.7 -0.0 0.1 -0.0 2.5 0.4 -1.4
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 4.9 0.0 2.2 0.5 -2.2 0.1 -1.3 0.1
Qualifications: None of the above 2.2 4.8 11.9 -2.2 -2.2 -3.4 2.1 -2.3 1.5 0.2
Financial difficulties in last 2 years 0.1 0.2 0.3 0.2 0.1 0.5 -0.2 -0.3 0.6 0.6
Mouth/teeth dental problems 0.5 0.8 2.3 -1.3 0.4 -1.5 -0.4 -0.9 -0.4 0.3
Heart attack 0.5 0.6 1.7 -0.5 0.6 0.5 -0.6 -1.3 -0.4 1.1
Allergy 0.1 0.3 0.9 0.8 0.0 -0.2 0.0 0.8 0.9 0.2
Pain all over the body in last month 0.4 0.4 1.5 0.0 -0.2 1.1 0.3 0.1 0.1 1.2
Diabetes (self-reported) 0.6 0.9 2.4 0.4 0.7 0.5 -0.7 -1.6 -0.9 1.3
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.1 1.1 0.1 1.0 -0.2 0.2 0.0 -0.4
Medication: Ramipril 1.2 1.5 3.0 -0.1 -1.6 0.1 1.7 -1.5 0.6 -1.5
Medication: Simvastatin 0.7 1.0 4.2 -1.0 -0.3 -2.0 0.2 -0.8 0.4 1.0
Fluid intelligence score 1.1 2.3 4.4 1.9 0.3 2.1 -0.2 1.8 2.1 -0.3
Illnesses of siblings 0.7 1.0 2.8 -0.1 -0.9 0.3 0.9 -0.2 1.7 -1.6
Neuroticism score 0.8 1.7 5.9 -0.8 1.5 0.7 -1.5 -0.4 -2.4 0.6
Weight 0.5 2.6 7.6 0.2 -1.6 -0.9 1.5 2.8 2.2 0.5
Impedance of arm (right) 0.2 0.8 3.0 0.1 1.0 1.7 -0.9 -0.4 -0.3 0.7
Arm fat percentage (right) 0.7 2.9 6.7 -1.3 -2.1 -1.5 2.0 0.9 2.6 0.5
Trunk fat-free mass 0.5 3.1 15.6 1.9 -0.3 0.9 0.2 4.0 1.1 0.3
Hip circumference 0.6 2.4 6.1 0.2 -1.3 -2.1 1.1 2.5 1.8 0.4
Time employed in main current job 1.2 1.4 4.2 -1.2 -0.2 -1.2 0.0 -2.1 -0.8 1.3
Alcohol intake versus 10 years previously 6.6 9.8 22.0 -3.1 -4.6 -1.0 4.7 -2.0 3.3 0.2
Father’s age at death 0.4 0.6 2.1 -0.6 0.4 -0.1 -0.4 -1.2 1.5 0.1
Worrier / anxious feelings 0.5 0.9 2.3 -0.6 1.2 0.0 -1.2 0.5 -1.0 1.5
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 3.4 -0.6 0.2 0.7 -0.1 -1.8 -1.4 1.6
Falls in the last year 0.4 0.6 1.9 -0.4 -0.7 0.7 0.8 -0.5 1.4 0.0
Hair/balding pattern: Pattern 3 0.5 0.8 2.3 0.5 1.5 0.5 -1.5 -0.3 -0.5 0.5
Number of live births 0.5 0.7 2.2 1.5 0.6 -0.1 -0.7 0.6 -0.8 -1.0
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 6.5 1.5 0.3 2.3 -0.2 2.5 0.9 1.4
Pulse rate 1.0 1.7 6.1 -2.5 -0.6 -0.4 0.6 -1.9 -0.5 -0.9
Happiness 1.2 1.5 4.3 0.4 1.4 1.0 -1.3 -1.0 -2.1 0.5
Noisy workplace 1.2 1.5 3.5 -0.6 -1.4 -1.3 1.3 0.5 1.9 -1.1
Qualifications: A levels/AS levels or equivalent 0.7 1.6 2.6 1.5 1.4 1.6 -1.4 0.4 -0.9 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.0 0.3 -0.6 1.4 0.6 0.0 1.0 -0.7
Mouth/teeth dental problems: Dentures 0.3 0.5 1.8 -0.5 0.1 -0.2 -0.1 -1.4 -1.0 0.4
Asthma 0.5 1.0 3.3 -1.5 -0.5 -1.8 0.4 -0.6 0.3 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.0 0.2 0.7 -0.9 -0.4 0.1 -1.0 0.8
Medication: Cholesterol lowering 1.0 1.5 8.6 -0.7 0.4 -0.4 -0.4 -0.7 -0.8 2.9
Depression (self-reported) 1.2 1.4 6.8 1.0 -0.4 2.6 0.6 1.2 0.3 -0.1
Medication: Lansoprazole 0.3 0.3 0.9 -0.9 -0.3 0.7 0.4 -0.7 -0.2 -0.1
Prospective memory result 1.4 1.7 4.2 1.9 1.0 2.0 -1.0 -0.2 -0.4 -1.2
Lung cancer (father) 0.5 0.6 1.4 0.5 -0.7 1.2 0.7 0.1 -1.0 -1.0
Illnesses of mother 0.3 0.3 1.1 -0.5 -0.3 1.0 0.2 -0.7 -0.0 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 4.2 1.0 -0.1 1.6 0.2 2.0 0.1 1.9
Pulse wave Arterial Stiffness index 2.3 2.7 7.8 -1.4 -1.5 -2.8 1.4 -0.8 0.8 1.8
Impedance of arm (left) 0.2 0.7 3.5 0.6 0.5 1.9 -0.4 -0.4 0.4 0.6
Arm fat mass (right) 0.6 2.4 5.5 -0.8 -1.8 -1.4 1.7 1.4 2.3 0.5
Trunk predicted mass 0.6 3.2 16.1 1.9 -0.3 0.9 0.3 4.0 1.2 0.3
Standing height 0.7 6.8 24.5 3.2 0.9 3.3 -0.7 5.0 0.5 0.6
Length of working week for main job 1.7 1.9 8.0 -0.8 0.3 -0.7 -0.2 -2.0 -0.1 2.8
Exposure to tobacco smoke at home 1.0 1.1 5.7 0.5 -0.4 -0.7 0.4 1.0 0.4 -2.4
Breastfed as a baby 0.4 0.5 1.2 -0.5 -1.0 0.5 0.8 -0.1 -0.1 1.1
Tense / ‘highly strung’ 0.9 1.4 5.5 1.2 0.9 2.3 -1.0 0.1 -1.1 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 4.3 0.3 0.3 2.1 -0.3 1.4 -0.1 0.6
Hair/balding pattern: Pattern 4 0.3 0.8 4.5 -0.7 -0.4 -2.1 0.5 0.5 -0.6 0.1
Birth weight of first child 1.3 2.4 4.8 1.0 2.0 2.2 -2.0 0.5 -1.5 0.8
Peak expiratory flow (PEF) 1.1 2.6 8.7 0.9 0.5 1.9 -0.4 2.9 1.1 1.9
Pulse wave reflection index 0.9 1.1 4.1 -0.7 -0.6 -2.0 0.6 -0.9 0.9 0.9
Ever highly irritable/argumentative for 2 days 0.6 0.7 3.1 0.6 0.2 0.2 -0.2 -0.6 -1.8 -0.8
Loud music exposure frequency 0.3 0.3 0.9 -0.7 -0.0 0.5 0.0 -0.5 -0.9 0.1
Qualifications: O levels/GCSEs or equivalent 2.2 3.5 10.8 1.3 -1.7 1.8 1.7 3.3 1.6 -0.3
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 4.7 0.7 -0.4 1.1 0.3 2.2 0.1 0.5
Blood clot in the leg (DVT) 0.8 1.0 2.5 0.9 1.6 1.1 -1.5 -0.1 -0.2 -0.6
Medication: Paracetamol 0.4 0.7 1.4 0.2 -1.0 1.2 1.1 -0.2 1.0 0.6
Headache pain in last month 0.4 0.6 1.2 -0.3 -0.8 1.1 0.8 0.6 0.8 0.8
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 6.9 0.9 -1.5 0.1 1.4 1.3 1.6 -2.6
Glaucoma (self-reported) 1.3 1.6 8.2 -0.9 -0.1 -2.9 0.1 -1.1 -0.8 0.0
Gout (self-reported) 0.3 0.5 1.6 1.3 0.7 0.5 -0.8 -0.1 -0.1 0.6
Hypothyroidism/myxoedema (self-reported) 1.3 2.5 4.9 2.1 1.5 1.5 -1.5 2.2 -0.1 -1.1
Medication: Amlodipine 1.3 1.8 4.1 -1.8 -1.2 -1.5 1.1 -0.6 0.1 2.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.7 -1.3 -0.0 -0.6 0.0 -0.3 -0.3 0.5
Birth weight 3.0 6.5 15.7 4.0 2.5 2.8 -2.5 2.7 -1.1 -0.5
Chronic bronchitis/emphysema (mother) 0.7 0.9 2.7 -0.6 -1.1 -0.4 1.1 -0.3 1.7 -0.3
High blood pressure (siblings) 0.3 0.4 1.2 0.2 0.6 0.2 -0.5 0.8 -0.7 1.1
Forced vital capacity (FVC), Best measure 0.6 2.0 7.0 1.6 0.2 1.5 -0.2 2.6 0.0 1.5
Body fat percentage 0.7 2.9 5.5 -1.5 -2.0 -1.9 1.9 0.2 2.4 0.9
Leg fat percentage (right) 1.0 3.7 6.1 -1.9 -2.2 -2.4 2.2 -0.2 2.5 0.6
Arm fat-free mass (right) 0.4 2.1 9.9 1.3 -0.8 -0.0 0.8 3.1 1.2 0.0
Exposure to tobacco smoke outside home 1.8 2.5 7.1 -0.7 -2.7 -0.9 2.4 0.0 1.5 -1.0
Comparative body size at age 10 1.4 3.8 5.3 2.2 2.3 1.9 -2.3 2.2 -0.4 1.6
Number of full brothers 1.6 2.1 3.8 -0.3 -1.9 -0.0 1.9 -1.9 1.8 -0.7
Worry too long after embarrassment 1.9 3.2 9.9 0.5 2.3 0.4 -2.4 0.5 -3.1 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.9 3.8 14.5 2.0 1.5 3.8 -1.4 1.8 0.8 0.0
Wheeze or whistling in the chest in last year 0.2 0.3 1.2 -0.4 0.3 -0.9 -0.3 -1.1 -0.1 -0.3
Number of children fathered 1.2 1.3 2.1 1.1 1.3 1.3 -1.4 0.2 -0.8 1.5
Reason for reducing amount of alcohol drunk: Health precaution 2.4 2.8 5.3 1.7 2.2 0.0 -2.2 2.3 -1.5 0.1
Age at first live birth 0.3 0.5 1.7 -0.1 0.7 -0.1 -0.7 1.3 -0.1 0.9
Pulse wave peak to peak time 2.6 3.1 9.6 1.7 1.6 3.1 -1.5 1.1 -0.8 -1.7
Health satisfaction 1.8 2.3 6.7 0.6 2.6 -0.1 -2.5 -0.6 -1.4 0.9
Shortness of breath walking on level ground 1.4 1.7 2.7 1.6 1.6 1.4 -1.6 -0.8 -0.1 -1.0
Qualifications: College or University degree 0.3 1.0 2.6 0.7 -0.4 0.8 0.3 1.6 1.2 -1.2
Eye problems/disorders: None of the above 1.6 1.8 4.8 0.7 -0.7 2.2 0.8 0.9 1.0 -2.1
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.5 1.5 1.4 0.1 -1.5 -0.6 -1.6 -0.8
Emphysema/chronic bronchitis 0.6 0.6 2.9 -0.6 -0.5 -0.1 0.4 -1.7 -0.6 0.6
Medication for pain relief, constipation, heartburn 0.3 0.5 1.0 -1.0 -0.7 -0.2 0.7 0.6 0.6 -1.0
Neck or shoulder pain in last month 0.6 0.8 4.8 0.3 -0.3 0.2 0.3 0.5 -0.7 2.2
Medication: Blood pressure 0.7 1.2 4.4 -0.6 0.7 -0.6 -0.7 -1.0 -1.3 2.1
Angina (self-reported) 0.4 0.6 1.7 -0.8 0.3 -1.1 -0.2 -1.3 -0.4 0.2
Migraine (self-reported) 0.4 0.5 1.3 0.8 0.3 0.5 -0.5 0.8 0.1 1.2
Medication: Ibuprofen 0.6 0.7 1.5 0.2 0.7 -1.2 -0.5 0.5 -1.1 1.0
Medication: Allopurinol 0.4 0.6 1.2 0.8 0.7 -0.2 -0.7 -0.9 -0.3 1.1
Medication: Omeprazole 0.4 0.5 2.8 0.0 -0.2 -0.1 0.2 -1.7 0.2 0.5
Medication: Seretide 50 evohaler 0.8 0.9 1.5 -1.1 -1.2 0.4 1.2 -0.8 1.2 0.5
Mean time to correctly identify matches 0.6 1.2 2.8 -0.3 1.1 -0.4 -1.1 -1.1 -1.7 -1.3
Heart disease (mother) 1.5 1.9 8.6 0.3 0.8 -0.2 -0.8 1.5 -0.9 2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 6.5 -1.2 -0.5 0.1 0.6 0.0 -0.2 2.5
Whole body fat mass 0.6 2.5 5.1 -0.9 -1.9 -1.7 1.8 1.3 2.2 1.0
Leg fat mass (right) 0.5 1.9 3.8 -0.8 -1.6 -1.7 1.5 1.1 1.9 0.6
Arm predicted mass (right) 0.4 2.2 10.8 1.4 -0.8 -0.1 0.8 3.3 1.1 -0.1
Pulse rate, automated reading 0.2 0.7 1.3 -1.1 -0.8 0.3 0.8 -1.1 -0.7 -0.6
Alcohol intake frequency. 0.6 1.4 3.6 -0.9 -1.0 -0.6 0.9 -1.8 0.7 1.9
Comparative height size at age 10 0.4 2.3 5.2 1.4 1.7 1.3 -1.6 2.3 -1.1 0.9
Number of full sisters 0.3 0.4 1.7 0.9 0.2 -0.1 -0.1 -1.3 0.5 0.0
Suffer from ‘nerves’ 0.6 0.9 2.2 -0.5 1.0 0.2 -1.0 1.5 -1.1 -0.9
Overall health rating 0.7 1.5 6.6 -1.2 -0.8 -0.4 0.7 -2.6 0.0 0.9
Chest pain or discomfort 0.5 0.7 1.6 -0.0 0.8 0.7 -0.8 -1.3 0.3 -1.1
Had major operations 0.5 0.6 3.0 -0.1 0.1 -0.5 -0.4 -1.0 -0.3 1.7
Age at last live birth 0.6 0.9 2.4 0.3 -0.2 0.2 0.1 1.5 1.1 1.5
Family relationship satisfaction 0.5 0.6 1.7 1.3 0.5 0.3 -0.5 -1.3 0.0 0.3
Leg pain on walking 0.4 0.5 1.3 -0.5 0.8 0.4 -0.8 -1.2 -0.5 -0.7
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 3.5 -1.1 1.2 0.1 -1.1 -1.7 -1.9 0.7
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.8 0.8 -0.1 -0.5 0.1 -0.5 1.6 1.7
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 2.0 0.2 0.6 -1.4 -0.6 0.5 -0.8 0.4
Medication: Aspirin 0.6 0.8 4.1 0.5 0.2 -0.9 -0.4 0.3 -0.1 2.0
Supplements: Vitamin C 2.0 2.3 9.8 0.6 1.3 0.2 -1.3 -1.2 -3.1 1.1
Knee pain experienced in last month 0.5 0.7 1.3 -0.5 0.9 -1.0 -0.9 0.4 -1.0 1.1
Hypertension (Self-reported) 0.6 1.7 3.0 1.0 1.3 -0.1 -1.4 1.1 -1.6 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 2.4 -0.5 0.6 0.0 -0.6 -1.6 -0.2 0.4
Illnesses of father: Heart disease 1.3 1.7 7.6 -2.8 -0.8 -0.7 0.9 -0.6 -1.1 1.1
Illnesses of siblings: Diabetes 0.4 0.5 1.3 0.2 1.1 0.1 -1.1 -0.9 0.2 0.0
Smoking status: Previous 0.7 1.0 3.3 -0.1 1.2 0.4 -1.2 1.8 -0.7 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.6 1.5 -0.4 1.8 0.4 2.1 0.9 0.9
Whole body fat-free mass 0.5 3.0 15.9 1.8 -0.5 0.6 0.5 4.0 1.1 0.2
Leg fat-free mass (right) 0.4 2.4 12.9 1.4 -0.7 0.2 0.5 3.6 1.0 -0.2
Arm fat percentage (left) 1.0 3.8 8.9 -1.2 -2.5 -1.8 2.4 0.8 3.0 0.6
Average weekly red wine intake 0.6 0.8 3.5 1.0 0.6 1.9 -0.5 0.6 -0.4 -0.0
Handedness (chirality/laterality): Left-handed 1.6 2.0 4.4 1.5 2.1 1.1 -2.1 -1.2 0.0 -0.2
Mood swings 0.5 0.8 2.7 -1.1 0.4 0.5 -0.3 -1.6 -1.2 -0.1
Loneliness, isolation 0.5 0.7 2.1 0.7 0.9 1.4 -0.8 0.2 -0.8 0.7
Long-standing illness, disability or infirmity 0.5 0.7 2.3 -0.8 -0.1 1.5 0.1 -0.2 -0.5 1.3
Ever had bowel cancer screening 0.7 0.8 1.6 1.0 1.2 1.2 -1.2 0.5 -0.5 0.4
Diabetes diagnosed by doctor 0.5 0.9 4.0 -0.3 -0.3 0.3 0.4 -2.0 -0.6 1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.0 4.5 -1.2 -2.0 0.4 2.1 0.6 1.8 -0.1
Friendships satisfaction 1.4 1.7 5.2 -0.0 1.3 0.2 -1.3 -2.3 -1.6 0.8
Qualifications: nursing, teaching 0.8 1.2 3.6 0.1 1.1 0.8 -1.1 -0.2 -1.2 1.9
Commuting to job workplace: Walk 1.4 1.5 3.5 -0.5 -1.8 1.6 1.9 -0.5 0.6 0.0
Eye problems/disorders: Cataract 0.7 0.8 2.1 1.0 1.3 -0.7 -1.4 0.5 0.4 0.6
Mouth/teeth dental problems: Mouth ulcers 2.1 3.4 8.1 2.7 1.4 2.8 -1.4 1.9 0.3 -0.8
Medication for cholesterol 0.8 1.3 3.5 1.0 1.4 -0.3 -1.4 -0.2 -0.5 1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.6 0.0 -1.3 0.4 1.2 0.6 0.3 0.3
Back pain experienced in last month 0.3 0.4 1.1 -0.7 0.7 -0.4 -0.7 -1.1 -0.1 -0.3
Mineral and other dietary supplements 0.7 0.9 2.2 -0.3 -1.0 1.0 1.1 -0.6 1.5 -0.8
Breast cancer (self-reported) 0.4 0.5 1.2 0.6 1.1 0.3 -1.1 0.5 -0.3 -0.3
Asthma (self-reported) 0.4 0.9 3.3 -1.4 -0.1 -1.8 0.1 -0.6 0.0 0.6
Osteoporosis (self-reported) 0.7 0.9 2.6 -1.1 -0.5 -1.1 0.5 -0.7 0.5 -1.6
Osteoarthritis (self-reported) 0.2 0.3 1.4 -1.2 -0.0 -0.3 0.1 -0.4 -0.4 0.4
Medication: Aspirin 0.7 0.9 3.4 0.6 0.4 -1.0 -0.6 0.8 -0.3 1.8
Medication: Gliclazide 0.5 0.6 2.3 1.2 0.2 1.5 -0.2 -0.3 0.3 0.0
Illnesses of father: None of the above (group 1) 0.1 0.2 0.8 0.9 0.3 -0.1 -0.3 0.3 -0.4 0.1
Smoking status: Current 0.7 1.1 3.9 2.0 -0.1 0.7 -0.0 -1.4 0.9 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.2 1.2 -0.1 1.5 0.1 0.4 1.3 1.1
Whole body water mass 0.5 2.6 13.8 1.6 -0.6 0.5 0.5 3.7 1.1 0.0
Leg predicted mass (right) 0.5 2.5 13.4 1.5 -0.6 0.2 0.5 3.7 1.0 -0.3
Arm fat mass (left) 0.7 2.8 5.7 -0.8 -2.1 -1.6 2.0 1.4 2.4 0.7
Number of self-reported non-cancer illnesses 0.7 1.3 3.6 0.5 0.7 1.1 -0.7 1.2 -1.2 1.9
Average weekly champagne plus white wine intake 1.0 1.3 4.2 1.2 1.1 -0.9 -1.1 0.4 0.5 2.0
Miserableness 1.6 2.7 4.8 -0.8 1.9 0.7 -1.8 -1.9 -2.2 1.5
Guilty feelings 2.9 4.4 10.5 0.8 2.7 1.0 -2.7 0.4 -3.2 2.0
Wears glasses or contact lenses 1.6 1.8 3.5 -0.5 1.9 -1.1 -1.9 1.1 -1.1 1.2
Ever taken oral contraceptive pill 1.4 1.5 3.3 1.8 1.1 1.1 -1.1 1.6 -0.7 -0.9
Hearing aid user 1.1 1.3 2.3 1.5 1.4 1.1 -1.4 1.0 -0.4 0.3
Mother’s age at death 0.3 0.4 1.0 -0.8 0.3 -0.4 -0.1 -0.9 -1.0 -0.4
Financial situation satisfaction 0.9 1.1 3.1 -1.5 0.8 0.6 -0.8 -0.8 -1.8 0.3
Tinnitus: Yes, now most or all of the time 1.4 1.6 4.5 -0.6 2.1 -0.2 -2.0 -1.4 -0.8 0.2
Commuting to job workplace: Public transport 2.6 3.1 10.1 1.9 -0.2 1.2 0.1 3.2 1.2 -2.2
Eye problems/disorders: Glaucoma 1.2 1.5 6.4 -1.5 -0.8 -2.5 0.7 -0.4 -0.5 -0.1
Medication: Blood pressure 0.6 1.1 2.3 0.8 -1.2 -0.1 1.0 1.3 0.8 -1.5
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.0 -0.8 0.4 -0.7 -0.5 -1.4 0.4 -0.1
Supplements: Fish oil (including cod liver oil) 1.1 1.4 4.6 0.1 1.1 -0.9 -1.2 0.9 -2.1 1.2
High cholesterol (Self-reported) 0.6 1.0 2.2 0.8 1.5 0.1 -1.5 1.0 -0.8 0.9
Medication: Bendroflumethiazide 0.3 0.5 2.2 -0.3 0.3 -0.4 -0.3 -0.0 -0.8 1.5
Medication: Paracetamol 0.4 0.7 1.3 0.5 -0.8 1.1 0.9 0.6 1.1 0.1
Medication: Lisinopril 0.9 1.2 3.0 -1.4 -0.4 -0.3 0.4 -1.5 -1.1 1.7
Medication: Atorvastatin 0.2 0.2 1.1 0.1 0.2 0.1 -0.2 -1.1 0.3 0.1
Illnesses of father: High blood pressure 2.0 2.4 5.7 -0.7 -2.2 -0.3 2.4 -1.0 1.9 -1.2
Alcohol drinker status: Never 0.9 1.1 2.5 -0.0 1.4 1.6 -1.4 0.2 -0.8 0.7
Ever smoked 1.3 2.3 6.9 1.0 1.3 2.6 -1.3 0.6 -2.1 0.0
Basal metabolic rate 0.5 2.6 13.1 1.3 -0.9 0.2 0.8 3.6 1.4 0.0
Leg fat percentage (left) 1.1 3.9 6.4 -2.2 -2.2 -2.5 2.2 -0.5 2.5 0.6
Arm fat-free mass (left) 0.3 1.5 8.1 0.9 -0.5 -0.0 0.5 2.9 0.8 0.1
Number of operations (self-reported) 0.4 0.5 1.1 1.0 0.0 1.1 -0.2 1.0 -0.4 0.8
Average weekly beer plus cider intake 4.0 5.7 13.1 -2.4 -2.3 -3.6 2.3 -1.8 1.8 -2.1
Irritability 0.5 0.8 2.6 -0.6 0.5 -0.2 -0.5 -0.8 -1.3 -1.6
Risk taking 1.4 2.1 5.1 1.8 -0.5 1.7 0.4 1.8 -0.1 -2.2
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.2 0.5 0.6 1.5 -0.5 1.4 -0.2 0.1
Fractured/broken bones in last 5 years 0.3 0.4 0.8 -0.9 -0.9 0.2 0.9 -0.1 0.4 -0.5
Age started oral contraceptive pill 0.7 0.9 4.0 0.3 -0.6 0.9 0.5 2.0 0.6 0.6
Diastolic blood pressure, automated reading 1.0 3.1 15.7 -1.8 -1.1 -4.0 1.1 -0.4 0.1 0.3
Ever depressed for a whole week 2.4 3.0 6.5 1.4 2.5 0.2 -2.5 0.1 -2.4 0.6
Unable to work because of sickness or disability 0.4 0.5 1.8 -0.1 -0.7 0.5 0.7 -1.3 0.0 0.4
Commuting to job workplace: Cycle 0.9 1.1 4.0 0.9 0.9 0.1 -0.8 1.0 -0.6 -2.0
Myopia 0.3 0.4 1.1 0.1 0.0 -0.9 0.1 0.3 -0.8 1.0
Vascular/heart problems diagnosed by doctor 0.5 1.3 3.1 -0.4 -1.3 0.3 1.3 -0.7 1.4 -1.8
Cholesterol lowering medication 0.2 0.4 1.1 0.6 -0.3 0.1 0.2 -0.1 0.9 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 2.0 -0.7 -0.2 -0.3 0.1 -1.4 -0.3 -0.1
Pain experienced in last month 0.3 0.5 1.3 -0.2 -1.2 0.1 1.1 -0.3 0.6 -0.5
Supplements: Calcium 1.4 1.6 5.2 0.4 1.5 0.4 -1.5 -0.9 -2.3 -0.6
Basal cell carcinoma (self-reported) 1.2 1.5 3.1 1.8 0.4 1.4 -0.3 1.4 0.5 -1.7
Heart attack/myocardial infarction (self-reported) 0.6 0.7 2.9 -0.6 0.6 0.5 -0.5 -1.7 -0.4 1.0
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 3.1 1.0 1.8 1.1 -1.7 -0.2 -0.3 -0.3
Heart disease (siblings) 0.8 1.0 4.4 -0.9 0.0 -0.9 -0.0 -0.3 -2.1 0.8
Alcohol drinker status: Previous 0.5 0.6 1.8 -1.2 -0.3 -0.3 0.3 -1.3 0.0 0.7
Pack years of smoking 0.8 1.1 2.2 -0.4 -1.2 -1.0 1.0 -1.2 1.5 -0.8
Impedance of whole body 0.2 0.8 3.2 0.1 0.8 1.8 -0.6 -1.0 -0.2 0.7
Leg fat mass (left) 0.6 2.2 3.9 -1.1 -1.7 -2.0 1.6 0.8 1.9 0.5
Arm predicted mass (left) 0.3 1.7 8.9 1.0 -0.7 0.1 0.6 3.0 1.0 0.1