Hub : Genes

PM20D2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1469	0.0435	1.3e-05	0.068	NA	0.085	NA	0.060	5.3e-06	NA	3.3e-07	NA	1.7e-05
2	GTEx	Cells EBV-transformed lymphocytes	0.3900	0.0830	5.0e-08	0.268	NA	0.229	NA	0.278	2.6e-09	NA	5.1e-08	NA	1.2e-09
3	GTEx	Esophagus Mucosa	0.1480	0.0540	1.5e-03	0.028	NA	0.020	NA	0.030	5.2e-03	NA	1.5e-02	NA	4.4e-03
4	GTEx	Heart Atrial Appendage	0.1000	0.0450	9.4e-03	-0.002	NA	-0.006	NA	0.037	4.0e-01	NA	7.5e-01	NA	8.9e-03
5	GTEx	Lung	0.0888	0.0428	1.0e-02	-0.002	NA	0.005	NA	-0.004	5.1e-01	NA	1.2e-01	NA	8.7e-01
6	GTEx	Ovary	0.2280	0.1020	5.9e-03	0.019	NA	0.148	NA	0.077	1.1e-01	NA	1.8e-04	NA	6.1e-03
7	YFS	Blood	0.0386	0.0133	3.0e-05	0.007	0.02	0.021	0.021	0.013	1.6e-03	3.4e-07	1.0e-07	1.8e-07	2.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.6	2.6	5.6	-0.4	-2.4	0.7	2.3	-0.0	2.0	1.6
Bipolar Disorder or Schizophrenia	1.1	2.8	7.0	-1.3	-2.6	0.9	2.6	-1.0	1.0	-1.1
Depressed Affect (Nagel 2018)	1.3	2.7	4.8	-0.2	2.0	0.7	-2.0	-2.2	-2.2	0.9
Depression (Nagel 2018)	1.1	1.7	4.6	1.1	1.2	1.4	-1.2	-1.1	-2.1	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.1	4.1	0.3	-0.6	1.1	0.6	2.0	1.2	-0.1
Neuroticism (Nagel 2018)	1.2	2.9	7.1	0.2	2.5	1.0	-2.5	-0.4	-2.7	-0.1
Schizophrenia (2018)	1.3	2.7	10.7	-1.4	-1.5	0.6	1.6	-1.1	-0.4	-3.3
Schizophrenia vs Biploar Disorder	2.6	3.4	5.9	-0.0	2.4	-1.4	-2.3	-1.7	-1.6	-2.3
Worry (Nagel 2018)	0.9	1.8	3.6	0.6	1.6	1.9	-1.6	1.1	-1.4	-0.6
Alzheimer’s Disease (in mother)	0.4	0.5	1.5	-0.1	-0.8	-1.2	0.8	0.4	-0.5	-0.0
Alzheimer’s Disease (in father)	0.8	0.8	3.6	-0.8	-0.7	-0.4	0.7	-0.5	0.3	1.9
Alzheimer’s Disease (including proxy)	0.5	0.8	2.2	-0.5	-0.9	-1.5	0.8	-0.7	-0.3	0.8
Crohns Disease (2017)	1.1	2.5	8.1	-0.9	0.9	-1.1	-1.0	-2.8	-1.1	2.1
Irritable Bowel Disease (IBD)	0.7	1.6	5.7	-0.6	-0.2	-0.8	0.2	-2.4	-0.8	2.0
Ulcerative Colitis (UC)	0.5	1.0	2.6	-0.4	-1.0	-0.5	1.0	-1.4	-0.3	1.6
Major Depression (MDD)	1.4	1.7	3.8	-1.4	1.4	-0.3	-1.3	-1.5	-2.0	0.2
Reaction Time	0.3	0.6	3.1	-0.0	0.3	-0.5	-0.4	0.2	-0.8	-1.8
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.8	1.6	0.2	2.0	-0.2	1.9	0.5	-0.9
Breast Cancer	0.9	2.2	4.4	2.1	0.5	2.1	-0.4	1.4	0.5	2.1
Ovarian Cancer	0.9	1.2	2.9	0.4	1.6	0.7	-1.4	-1.7	-0.8	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.1	1.5	5.4	1.9	-0.1	1.2	-0.2	2.3	0.2	-0.0
Bipolar Disorder (2011)	0.8	0.7	1.7	-0.5	-1.3	0.4	1.3	0.7	0.5	0.8
Body Mass Index (BMI) (2010)	0.2	0.3	1.2	0.1	0.4	-0.3	-0.5	1.1	-0.5	0.2
Coronary Artery Disease (CAD)	0.4	0.5	3.1	0.0	0.2	-0.2	-0.4	0.1	0.1	-1.8
Crohns Disease (2012)	1.5	2.4	6.9	-1.0	0.8	0.8	-0.7	-2.2	-1.6	2.6
Mean Putamen Volume	0.4	0.4	0.9	-0.4	0.7	-0.6	-0.7	-0.8	-0.9	0.1
Fasting Glucose	0.3	0.3	1.6	-1.3	0.2	-0.1	-0.2	0.2	-0.6	-0.6
HbA1C	0.5	0.5	1.0	0.5	0.8	0.5	-0.9	-0.4	-1.0	0.8
HDL Cholesterol	0.6	1.0	2.2	0.8	1.4	0.9	-1.5	-0.0	-0.5	1.2
LDL Cholesterol	0.1	0.1	0.3	-0.0	0.2	0.3	-0.2	0.4	0.5	-0.3
Lupus	0.5	0.7	1.3	1.1	1.0	0.7	-0.9	1.1	0.2	0.5
Neuroticism (2016)	1.0	1.4	2.4	0.8	1.4	1.5	-1.5	1.5	-0.6	-0.2
Primary Biliary Cirrhosis	0.9	1.4	4.1	1.1	-0.8	2.0	0.8	1.4	0.7	-0.7
Rheumatoid Arthritis	1.1	1.5	4.0	1.2	0.3	0.1	-0.3	1.4	2.0	1.7
Schizophrenia (2014)	0.8	1.7	7.1	-0.7	-0.8	0.5	0.9	-1.6	0.2	-2.7
Triglycerides	0.6	1.0	2.3	-0.4	-1.5	0.0	1.5	1.1	1.1	-0.5
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.1	0.8	1.6	0.6	-2.0	0.2	-1.3	-0.4
Ulcerative Colitis	0.7	1.0	1.9	-0.7	-1.2	0.2	1.2	-1.1	-0.8	1.4
Blood Eosinophil Count	0.4	2.9	7.2	1.9	-2.0	-0.3	1.6	0.7	2.7	1.4
Blood Platelet Count	0.3	3.0	6.0	-2.5	-2.1	-1.1	2.1	-2.0	0.4	-1.0
Blood Red Count	0.1	0.6	2.2	-1.5	0.3	-0.0	-0.3	-0.5	-0.9	0.7
Blood White Count	0.4	2.8	7.7	-2.8	-1.9	-1.2	1.8	-1.5	1.0	0.8
Heel T-Score	0.2	1.5	2.6	0.7	1.1	-0.6	-1.1	1.6	-1.6	1.5
BMI	0.4	2.3	4.7	-0.5	-1.8	-1.8	1.7	1.4	2.2	0.5
Height	0.4	8.6	31.8	2.0	0.9	4.0	-0.7	5.6	0.6	2.6
Waist Hip Ratio (WHR)	0.5	2.3	4.3	-0.4	-1.9	1.7	2.1	-0.5	1.8	-1.4
Systolic Blood Pressure	0.1	0.6	4.2	-0.3	0.1	-2.0	0.1	-0.2	-0.4	0.0
Smoking Status	0.2	0.4	1.1	1.1	0.7	0.4	-0.6	-0.3	0.7	0.5
Allergy or Eczema	0.1	0.1	0.5	-0.5	-0.2	0.7	0.2	-0.0	-0.5	-0.0
Cardiovascular Disease	0.3	0.9	1.9	1.3	0.4	0.9	-0.4	1.2	0.1	1.4
Hypothyroidism (self reported)	2.1	4.8	8.6	2.6	2.5	2.1	-2.5	2.9	-0.3	-1.1
Respiratory disease	0.3	0.6	1.1	-0.9	0.1	-0.9	-0.4	-1.0	-0.7	0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.2	0.1	-0.8	0.1	0.9	-1.0	1.1	0.2
Lung FEV1/FVC ratio	0.2	1.1	3.2	-1.4	-0.5	-0.7	0.6	-1.3	-0.2	1.8
Lung FVC	0.1	0.4	1.2	1.1	0.8	-0.0	-0.9	0.2	-0.2	0.4
Neuroticism	1.4	3.4	8.0	-0.1	2.4	1.9	-2.5	-0.8	-2.8	0.0
Chronotype (morning person)	1.5	3.6	9.1	1.0	2.3	1.1	-2.1	0.0	-3.0	2.0
Hair Pigment	0.0	1.2	2.6	0.8	1.3	-0.5	-1.2	-0.8	-1.0	1.6
Tanning	0.2	1.9	6.0	-0.5	-2.4	-0.8	2.5	-0.4	0.7	-0.4
Hand grip strength (left)	1.1	2.8	7.6	1.9	0.3	2.4	-0.3	2.8	-0.3	-1.6
Number of treatments/medications taken	0.4	0.7	3.3	0.1	0.4	0.2	-0.5	-0.4	-1.1	1.8
Average weekly spirits intake	0.4	0.5	1.8	-0.6	-0.5	0.3	0.5	0.2	0.9	-1.3
Sensitivity / hurt feelings	0.3	0.6	2.1	-0.2	0.1	1.4	-0.1	1.1	-0.7	0.1
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.8	-0.2	0.2	1.4	-0.2	-1.1	-1.7	0.4
Hearing difficulty/problems: Yes	3.1	4.7	8.2	2.9	2.9	2.3	-2.8	1.4	-1.2	-0.4
Relative age of first facial hair	0.4	0.9	3.4	0.5	-0.2	1.9	0.3	-1.5	0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.2	1.0	1.0	1.8	-0.9	0.8	-0.5	0.9
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.2	0.8	1.6	1.8	-1.4	-0.6	-1.4	-1.2
Ever had hysterectomy (womb removed)	0.3	0.3	1.3	-0.6	-0.4	-0.6	0.4	-0.1	-0.0	-1.1
Systolic blood pressure, automated reading	0.6	1.8	9.7	-1.5	-0.3	-3.1	0.3	-0.3	-0.8	0.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.8	-1.3	-1.3	-0.4	1.4	-0.1	-0.3	0.4
Angina	0.7	0.9	3.3	-0.7	0.5	-1.2	-0.4	-1.8	-0.7	0.4
Medication for hormone replacement therapy	0.8	0.9	3.5	-0.4	-0.4	0.8	0.5	-0.9	0.8	-1.9
Vitamin and mineral supplements	0.8	1.1	3.9	0.7	-1.2	0.2	1.1	0.4	2.0	-0.6
Supplements: Zinc	1.1	1.2	4.7	-0.4	0.7	-0.7	-0.8	-0.7	-2.2	1.1
Medication: Co-codamol	0.5	0.6	2.2	1.5	-0.4	-0.6	0.2	1.1	0.1	0.1
Medication: Metformin	0.1	0.2	0.4	0.6	-0.1	0.4	0.1	0.5	0.5	-0.4
Diabetes (father)	1.1	1.3	3.1	-1.6	-1.8	-0.6	1.6	0.0	0.6	-0.3
Diabetes (mother)	1.1	1.4	5.4	-0.1	-0.8	-1.4	0.7	-1.2	2.3	-0.5
Severe depression (siblings)	0.8	0.9	3.6	0.8	0.1	0.4	-0.2	1.2	-1.9	0.8
Pack years adult smoking proportion	0.6	1.0	2.7	-0.2	-1.3	-0.6	1.1	-0.7	1.6	-0.6
Impedance of leg (right)	0.2	0.8	2.2	-0.2	0.7	1.5	-0.4	-1.3	-0.4	1.1
Leg fat-free mass (left)	0.5	2.9	14.9	1.5	-0.8	0.2	0.7	3.9	1.3	-0.2
Trunk fat percentage	0.6	2.6	4.2	-1.6	-2.0	-1.7	1.9	0.4	2.0	1.0
Hand grip strength (right)	1.4	3.7	9.9	2.3	0.9	3.1	-0.9	2.3	-0.2	-1.9
Townsend deprivation index at recruitment	1.0	1.3	2.1	-1.4	-1.4	-0.9	1.3	-1.0	1.5	0.1
Current tobacco smoking	0.6	1.0	4.3	2.1	0.0	0.5	-0.1	-1.2	1.0	-0.0
Average weekly fortified wine intake	0.4	0.5	1.1	-0.0	-0.8	0.2	0.8	-0.0	1.0	-0.9
Maternal smoking around birth	1.2	1.8	3.0	0.1	-1.6	-1.0	1.5	-1.4	1.7	-1.2
Fed-up feelings	0.8	1.4	3.2	-1.0	1.2	-0.6	-1.1	-1.7	-1.8	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	4.6	-1.0	-0.5	-0.1	0.7	-2.1	-1.8	0.4
Relative age voice broke	0.7	1.1	3.4	0.9	0.5	1.8	-0.5	1.2	-1.0	-0.8
Taking other prescription medications	0.5	0.8	2.2	-0.5	0.6	0.7	-0.5	-0.4	-1.4	1.5
Age when periods started (menarche)	0.9	2.3	8.8	0.8	-0.5	3.0	0.6	2.3	0.7	0.3
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.5	-0.9	-1.5	-0.6	1.6	-0.6	-0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	11.0	0.6	-0.5	0.4	0.4	3.3	0.6	-1.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.4	-0.3	-0.6	0.3	-0.2	0.1	-0.2
Qualifications: CSEs or equivalent	0.3	0.4	1.9	0.1	0.2	-0.7	-0.1	-0.4	-0.0	1.4
Serious illness, injury or assault to yourself	0.6	0.8	1.6	0.6	0.4	1.3	-0.4	-1.1	1.0	1.0
High blood pressure	0.6	1.5	2.4	1.1	1.3	-0.2	-1.4	1.4	-1.6	1.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.2	-0.1	-0.9	1.1	0.8	-0.3	-0.2	-0.2
Multivitamins +/- minerals	0.6	0.8	1.8	-0.0	1.3	-0.2	-1.3	0.7	-1.3	0.3
Stomach or abdominal pain in last month	0.7	0.8	2.6	1.6	0.6	1.6	-0.5	0.0	0.3	0.1
Supplements: Glucosamine	0.4	0.6	1.4	-0.1	0.3	-1.1	-0.3	0.2	-1.1	1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.4	-1.2	0.2	-0.2	-0.0	-0.7	0.7	0.3
Medication: Atenolol	1.0	1.3	6.6	-0.3	0.4	-2.6	-0.3	-0.0	-0.7	1.2
Medication: Levothyroxine sodium	0.4	0.8	1.6	0.4	0.9	0.8	-0.9	-0.4	1.3	-1.0
Sitting height	0.6	4.0	17.1	1.8	-0.7	0.4	0.8	4.1	2.3	0.9
Chronic bronchitis/emphysema (father)	0.8	1.0	2.6	0.7	-0.8	1.6	0.7	-0.1	1.6	0.3
High blood pressure (mother)	0.3	0.4	1.1	0.5	-0.1	-0.9	0.2	0.6	1.0	0.0
Body mass index (BMI)	0.6	2.7	6.4	-1.4	-1.9	-2.5	1.8	0.5	1.9	0.4
Impedance of leg (left)	0.3	1.3	3.8	-0.7	0.8	1.4	-0.6	-2.0	-0.7	1.1
Leg predicted mass (left)	0.5	2.9	14.9	1.6	-0.8	0.2	0.7	3.9	1.3	-0.2
Trunk fat mass	0.6	2.8	4.9	-1.1	-2.1	-1.5	2.0	1.4	2.2	0.9
Waist circumference	1.1	3.9	9.2	-1.0	-2.7	-1.3	2.6	1.2	3.0	0.2
Number of incorrect matches in round	0.5	0.8	1.9	0.5	0.6	1.4	-0.7	-0.8	-1.0	-1.0
Past tobacco smoking	0.8	1.6	2.4	-0.6	-1.4	-1.5	1.3	-1.3	1.2	-1.1
Alcohol usually taken with meals	2.2	3.6	8.2	2.0	2.9	1.6	-2.7	1.4	-0.5	0.9
Nervous feelings	1.3	2.5	5.1	0.5	2.2	1.3	-2.2	0.9	-2.3	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	4.0	1.2	1.3	0.5	-1.4	-0.0	-2.0	-0.9
Hearing difficulty/problems with background noise	2.6	4.1	6.3	1.9	2.3	2.5	-2.3	2.1	-1.8	-0.6
Hair/balding pattern: Pattern 2	0.2	0.2	1.3	-0.3	0.1	1.2	-0.0	0.3	-0.3	-0.2
Had menopause	0.6	0.8	1.7	-0.2	1.1	0.3	-1.0	1.0	-0.6	1.3
Had other major operations	0.9	1.1	2.3	0.4	-1.3	0.5	1.4	0.7	1.5	-1.0
Forced vital capacity (FVC)	0.9	3.4	11.3	2.1	0.3	2.4	-0.3	3.4	1.1	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	6.2	0.7	-0.0	0.1	-0.0	2.5	0.4	-1.4
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	4.9	0.0	2.2	0.5	-2.2	0.1	-1.3	0.1
Qualifications: None of the above	2.2	4.8	11.9	-2.2	-2.2	-3.4	2.1	-2.3	1.5	0.2
Financial difficulties in last 2 years	0.1	0.2	0.3	0.2	0.1	0.5	-0.2	-0.3	0.6	0.6
Mouth/teeth dental problems	0.5	0.8	2.3	-1.3	0.4	-1.5	-0.4	-0.9	-0.4	0.3
Heart attack	0.5	0.6	1.7	-0.5	0.6	0.5	-0.6	-1.3	-0.4	1.1
Allergy	0.1	0.3	0.9	0.8	0.0	-0.2	0.0	0.8	0.9	0.2
Pain all over the body in last month	0.4	0.4	1.5	0.0	-0.2	1.1	0.3	0.1	0.1	1.2
Diabetes (self-reported)	0.6	0.9	2.4	0.4	0.7	0.5	-0.7	-1.6	-0.9	1.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.1	1.1	0.1	1.0	-0.2	0.2	0.0	-0.4
Medication: Ramipril	1.2	1.5	3.0	-0.1	-1.6	0.1	1.7	-1.5	0.6	-1.5
Medication: Simvastatin	0.7	1.0	4.2	-1.0	-0.3	-2.0	0.2	-0.8	0.4	1.0
Fluid intelligence score	1.1	2.3	4.4	1.9	0.3	2.1	-0.2	1.8	2.1	-0.3
Illnesses of siblings	0.7	1.0	2.8	-0.1	-0.9	0.3	0.9	-0.2	1.7	-1.6
Neuroticism score	0.8	1.7	5.9	-0.8	1.5	0.7	-1.5	-0.4	-2.4	0.6
Weight	0.5	2.6	7.6	0.2	-1.6	-0.9	1.5	2.8	2.2	0.5
Impedance of arm (right)	0.2	0.8	3.0	0.1	1.0	1.7	-0.9	-0.4	-0.3	0.7
Arm fat percentage (right)	0.7	2.9	6.7	-1.3	-2.1	-1.5	2.0	0.9	2.6	0.5
Trunk fat-free mass	0.5	3.1	15.6	1.9	-0.3	0.9	0.2	4.0	1.1	0.3
Hip circumference	0.6	2.4	6.1	0.2	-1.3	-2.1	1.1	2.5	1.8	0.4
Time employed in main current job	1.2	1.4	4.2	-1.2	-0.2	-1.2	0.0	-2.1	-0.8	1.3
Alcohol intake versus 10 years previously	6.6	9.8	22.0	-3.1	-4.6	-1.0	4.7	-2.0	3.3	0.2
Father’s age at death	0.4	0.6	2.1	-0.6	0.4	-0.1	-0.4	-1.2	1.5	0.1
Worrier / anxious feelings	0.5	0.9	2.3	-0.6	1.2	0.0	-1.2	0.5	-1.0	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.4	-0.6	0.2	0.7	-0.1	-1.8	-1.4	1.6
Falls in the last year	0.4	0.6	1.9	-0.4	-0.7	0.7	0.8	-0.5	1.4	0.0
Hair/balding pattern: Pattern 3	0.5	0.8	2.3	0.5	1.5	0.5	-1.5	-0.3	-0.5	0.5
Number of live births	0.5	0.7	2.2	1.5	0.6	-0.1	-0.7	0.6	-0.8	-1.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	6.5	1.5	0.3	2.3	-0.2	2.5	0.9	1.4
Pulse rate	1.0	1.7	6.1	-2.5	-0.6	-0.4	0.6	-1.9	-0.5	-0.9
Happiness	1.2	1.5	4.3	0.4	1.4	1.0	-1.3	-1.0	-2.1	0.5
Noisy workplace	1.2	1.5	3.5	-0.6	-1.4	-1.3	1.3	0.5	1.9	-1.1
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.6	1.5	1.4	1.6	-1.4	0.4	-0.9	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.0	0.3	-0.6	1.4	0.6	0.0	1.0	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	1.8	-0.5	0.1	-0.2	-0.1	-1.4	-1.0	0.4
Asthma	0.5	1.0	3.3	-1.5	-0.5	-1.8	0.4	-0.6	0.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	0.2	0.7	-0.9	-0.4	0.1	-1.0	0.8
Medication: Cholesterol lowering	1.0	1.5	8.6	-0.7	0.4	-0.4	-0.4	-0.7	-0.8	2.9
Depression (self-reported)	1.2	1.4	6.8	1.0	-0.4	2.6	0.6	1.2	0.3	-0.1
Medication: Lansoprazole	0.3	0.3	0.9	-0.9	-0.3	0.7	0.4	-0.7	-0.2	-0.1
Prospective memory result	1.4	1.7	4.2	1.9	1.0	2.0	-1.0	-0.2	-0.4	-1.2
Lung cancer (father)	0.5	0.6	1.4	0.5	-0.7	1.2	0.7	0.1	-1.0	-1.0
Illnesses of mother	0.3	0.3	1.1	-0.5	-0.3	1.0	0.2	-0.7	-0.0	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.2	1.0	-0.1	1.6	0.2	2.0	0.1	1.9
Pulse wave Arterial Stiffness index	2.3	2.7	7.8	-1.4	-1.5	-2.8	1.4	-0.8	0.8	1.8
Impedance of arm (left)	0.2	0.7	3.5	0.6	0.5	1.9	-0.4	-0.4	0.4	0.6
Arm fat mass (right)	0.6	2.4	5.5	-0.8	-1.8	-1.4	1.7	1.4	2.3	0.5
Trunk predicted mass	0.6	3.2	16.1	1.9	-0.3	0.9	0.3	4.0	1.2	0.3
Standing height	0.7	6.8	24.5	3.2	0.9	3.3	-0.7	5.0	0.5	0.6
Length of working week for main job	1.7	1.9	8.0	-0.8	0.3	-0.7	-0.2	-2.0	-0.1	2.8
Exposure to tobacco smoke at home	1.0	1.1	5.7	0.5	-0.4	-0.7	0.4	1.0	0.4	-2.4
Breastfed as a baby	0.4	0.5	1.2	-0.5	-1.0	0.5	0.8	-0.1	-0.1	1.1
Tense / ‘highly strung’	0.9	1.4	5.5	1.2	0.9	2.3	-1.0	0.1	-1.1	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	4.3	0.3	0.3	2.1	-0.3	1.4	-0.1	0.6
Hair/balding pattern: Pattern 4	0.3	0.8	4.5	-0.7	-0.4	-2.1	0.5	0.5	-0.6	0.1
Birth weight of first child	1.3	2.4	4.8	1.0	2.0	2.2	-2.0	0.5	-1.5	0.8
Peak expiratory flow (PEF)	1.1	2.6	8.7	0.9	0.5	1.9	-0.4	2.9	1.1	1.9
Pulse wave reflection index	0.9	1.1	4.1	-0.7	-0.6	-2.0	0.6	-0.9	0.9	0.9
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.1	0.6	0.2	0.2	-0.2	-0.6	-1.8	-0.8
Loud music exposure frequency	0.3	0.3	0.9	-0.7	-0.0	0.5	0.0	-0.5	-0.9	0.1
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	10.8	1.3	-1.7	1.8	1.7	3.3	1.6	-0.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	4.7	0.7	-0.4	1.1	0.3	2.2	0.1	0.5
Blood clot in the leg (DVT)	0.8	1.0	2.5	0.9	1.6	1.1	-1.5	-0.1	-0.2	-0.6
Medication: Paracetamol	0.4	0.7	1.4	0.2	-1.0	1.2	1.1	-0.2	1.0	0.6
Headache pain in last month	0.4	0.6	1.2	-0.3	-0.8	1.1	0.8	0.6	0.8	0.8
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	6.9	0.9	-1.5	0.1	1.4	1.3	1.6	-2.6
Glaucoma (self-reported)	1.3	1.6	8.2	-0.9	-0.1	-2.9	0.1	-1.1	-0.8	0.0
Gout (self-reported)	0.3	0.5	1.6	1.3	0.7	0.5	-0.8	-0.1	-0.1	0.6
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	4.9	2.1	1.5	1.5	-1.5	2.2	-0.1	-1.1
Medication: Amlodipine	1.3	1.8	4.1	-1.8	-1.2	-1.5	1.1	-0.6	0.1	2.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.7	-1.3	-0.0	-0.6	0.0	-0.3	-0.3	0.5
Birth weight	3.0	6.5	15.7	4.0	2.5	2.8	-2.5	2.7	-1.1	-0.5
Chronic bronchitis/emphysema (mother)	0.7	0.9	2.7	-0.6	-1.1	-0.4	1.1	-0.3	1.7	-0.3
High blood pressure (siblings)	0.3	0.4	1.2	0.2	0.6	0.2	-0.5	0.8	-0.7	1.1
Forced vital capacity (FVC), Best measure	0.6	2.0	7.0	1.6	0.2	1.5	-0.2	2.6	0.0	1.5
Body fat percentage	0.7	2.9	5.5	-1.5	-2.0	-1.9	1.9	0.2	2.4	0.9
Leg fat percentage (right)	1.0	3.7	6.1	-1.9	-2.2	-2.4	2.2	-0.2	2.5	0.6
Arm fat-free mass (right)	0.4	2.1	9.9	1.3	-0.8	-0.0	0.8	3.1	1.2	0.0
Exposure to tobacco smoke outside home	1.8	2.5	7.1	-0.7	-2.7	-0.9	2.4	0.0	1.5	-1.0
Comparative body size at age 10	1.4	3.8	5.3	2.2	2.3	1.9	-2.3	2.2	-0.4	1.6
Number of full brothers	1.6	2.1	3.8	-0.3	-1.9	-0.0	1.9	-1.9	1.8	-0.7
Worry too long after embarrassment	1.9	3.2	9.9	0.5	2.3	0.4	-2.4	0.5	-3.1	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.9	3.8	14.5	2.0	1.5	3.8	-1.4	1.8	0.8	0.0
Wheeze or whistling in the chest in last year	0.2	0.3	1.2	-0.4	0.3	-0.9	-0.3	-1.1	-0.1	-0.3
Number of children fathered	1.2	1.3	2.1	1.1	1.3	1.3	-1.4	0.2	-0.8	1.5
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	5.3	1.7	2.2	0.0	-2.2	2.3	-1.5	0.1
Age at first live birth	0.3	0.5	1.7	-0.1	0.7	-0.1	-0.7	1.3	-0.1	0.9
Pulse wave peak to peak time	2.6	3.1	9.6	1.7	1.6	3.1	-1.5	1.1	-0.8	-1.7
Health satisfaction	1.8	2.3	6.7	0.6	2.6	-0.1	-2.5	-0.6	-1.4	0.9
Shortness of breath walking on level ground	1.4	1.7	2.7	1.6	1.6	1.4	-1.6	-0.8	-0.1	-1.0
Qualifications: College or University degree	0.3	1.0	2.6	0.7	-0.4	0.8	0.3	1.6	1.2	-1.2
Eye problems/disorders: None of the above	1.6	1.8	4.8	0.7	-0.7	2.2	0.8	0.9	1.0	-2.1
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.5	1.5	1.4	0.1	-1.5	-0.6	-1.6	-0.8
Emphysema/chronic bronchitis	0.6	0.6	2.9	-0.6	-0.5	-0.1	0.4	-1.7	-0.6	0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	-1.0	-0.7	-0.2	0.7	0.6	0.6	-1.0
Neck or shoulder pain in last month	0.6	0.8	4.8	0.3	-0.3	0.2	0.3	0.5	-0.7	2.2
Medication: Blood pressure	0.7	1.2	4.4	-0.6	0.7	-0.6	-0.7	-1.0	-1.3	2.1
Angina (self-reported)	0.4	0.6	1.7	-0.8	0.3	-1.1	-0.2	-1.3	-0.4	0.2
Migraine (self-reported)	0.4	0.5	1.3	0.8	0.3	0.5	-0.5	0.8	0.1	1.2
Medication: Ibuprofen	0.6	0.7	1.5	0.2	0.7	-1.2	-0.5	0.5	-1.1	1.0
Medication: Allopurinol	0.4	0.6	1.2	0.8	0.7	-0.2	-0.7	-0.9	-0.3	1.1
Medication: Omeprazole	0.4	0.5	2.8	0.0	-0.2	-0.1	0.2	-1.7	0.2	0.5
Medication: Seretide 50 evohaler	0.8	0.9	1.5	-1.1	-1.2	0.4	1.2	-0.8	1.2	0.5
Mean time to correctly identify matches	0.6	1.2	2.8	-0.3	1.1	-0.4	-1.1	-1.1	-1.7	-1.3
Heart disease (mother)	1.5	1.9	8.6	0.3	0.8	-0.2	-0.8	1.5	-0.9	2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	6.5	-1.2	-0.5	0.1	0.6	0.0	-0.2	2.5
Whole body fat mass	0.6	2.5	5.1	-0.9	-1.9	-1.7	1.8	1.3	2.2	1.0
Leg fat mass (right)	0.5	1.9	3.8	-0.8	-1.6	-1.7	1.5	1.1	1.9	0.6
Arm predicted mass (right)	0.4	2.2	10.8	1.4	-0.8	-0.1	0.8	3.3	1.1	-0.1
Pulse rate, automated reading	0.2	0.7	1.3	-1.1	-0.8	0.3	0.8	-1.1	-0.7	-0.6
Alcohol intake frequency.	0.6	1.4	3.6	-0.9	-1.0	-0.6	0.9	-1.8	0.7	1.9
Comparative height size at age 10	0.4	2.3	5.2	1.4	1.7	1.3	-1.6	2.3	-1.1	0.9
Number of full sisters	0.3	0.4	1.7	0.9	0.2	-0.1	-0.1	-1.3	0.5	0.0
Suffer from ‘nerves’	0.6	0.9	2.2	-0.5	1.0	0.2	-1.0	1.5	-1.1	-0.9
Overall health rating	0.7	1.5	6.6	-1.2	-0.8	-0.4	0.7	-2.6	0.0	0.9
Chest pain or discomfort	0.5	0.7	1.6	-0.0	0.8	0.7	-0.8	-1.3	0.3	-1.1
Had major operations	0.5	0.6	3.0	-0.1	0.1	-0.5	-0.4	-1.0	-0.3	1.7
Age at last live birth	0.6	0.9	2.4	0.3	-0.2	0.2	0.1	1.5	1.1	1.5
Family relationship satisfaction	0.5	0.6	1.7	1.3	0.5	0.3	-0.5	-1.3	0.0	0.3
Leg pain on walking	0.4	0.5	1.3	-0.5	0.8	0.4	-0.8	-1.2	-0.5	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.5	-1.1	1.2	0.1	-1.1	-1.7	-1.9	0.7
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.8	0.8	-0.1	-0.5	0.1	-0.5	1.6	1.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.0	0.2	0.6	-1.4	-0.6	0.5	-0.8	0.4
Medication: Aspirin	0.6	0.8	4.1	0.5	0.2	-0.9	-0.4	0.3	-0.1	2.0
Supplements: Vitamin C	2.0	2.3	9.8	0.6	1.3	0.2	-1.3	-1.2	-3.1	1.1
Knee pain experienced in last month	0.5	0.7	1.3	-0.5	0.9	-1.0	-0.9	0.4	-1.0	1.1
Hypertension (Self-reported)	0.6	1.7	3.0	1.0	1.3	-0.1	-1.4	1.1	-1.6	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.4	-0.5	0.6	0.0	-0.6	-1.6	-0.2	0.4
Illnesses of father: Heart disease	1.3	1.7	7.6	-2.8	-0.8	-0.7	0.9	-0.6	-1.1	1.1
Illnesses of siblings: Diabetes	0.4	0.5	1.3	0.2	1.1	0.1	-1.1	-0.9	0.2	0.0
Smoking status: Previous	0.7	1.0	3.3	-0.1	1.2	0.4	-1.2	1.8	-0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.6	1.5	-0.4	1.8	0.4	2.1	0.9	0.9
Whole body fat-free mass	0.5	3.0	15.9	1.8	-0.5	0.6	0.5	4.0	1.1	0.2
Leg fat-free mass (right)	0.4	2.4	12.9	1.4	-0.7	0.2	0.5	3.6	1.0	-0.2
Arm fat percentage (left)	1.0	3.8	8.9	-1.2	-2.5	-1.8	2.4	0.8	3.0	0.6
Average weekly red wine intake	0.6	0.8	3.5	1.0	0.6	1.9	-0.5	0.6	-0.4	-0.0
Handedness (chirality/laterality): Left-handed	1.6	2.0	4.4	1.5	2.1	1.1	-2.1	-1.2	0.0	-0.2
Mood swings	0.5	0.8	2.7	-1.1	0.4	0.5	-0.3	-1.6	-1.2	-0.1
Loneliness, isolation	0.5	0.7	2.1	0.7	0.9	1.4	-0.8	0.2	-0.8	0.7
Long-standing illness, disability or infirmity	0.5	0.7	2.3	-0.8	-0.1	1.5	0.1	-0.2	-0.5	1.3
Ever had bowel cancer screening	0.7	0.8	1.6	1.0	1.2	1.2	-1.2	0.5	-0.5	0.4
Diabetes diagnosed by doctor	0.5	0.9	4.0	-0.3	-0.3	0.3	0.4	-2.0	-0.6	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	4.5	-1.2	-2.0	0.4	2.1	0.6	1.8	-0.1
Friendships satisfaction	1.4	1.7	5.2	-0.0	1.3	0.2	-1.3	-2.3	-1.6	0.8
Qualifications: nursing, teaching	0.8	1.2	3.6	0.1	1.1	0.8	-1.1	-0.2	-1.2	1.9
Commuting to job workplace: Walk	1.4	1.5	3.5	-0.5	-1.8	1.6	1.9	-0.5	0.6	0.0
Eye problems/disorders: Cataract	0.7	0.8	2.1	1.0	1.3	-0.7	-1.4	0.5	0.4	0.6
Mouth/teeth dental problems: Mouth ulcers	2.1	3.4	8.1	2.7	1.4	2.8	-1.4	1.9	0.3	-0.8
Medication for cholesterol	0.8	1.3	3.5	1.0	1.4	-0.3	-1.4	-0.2	-0.5	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.6	0.0	-1.3	0.4	1.2	0.6	0.3	0.3
Back pain experienced in last month	0.3	0.4	1.1	-0.7	0.7	-0.4	-0.7	-1.1	-0.1	-0.3
Mineral and other dietary supplements	0.7	0.9	2.2	-0.3	-1.0	1.0	1.1	-0.6	1.5	-0.8
Breast cancer (self-reported)	0.4	0.5	1.2	0.6	1.1	0.3	-1.1	0.5	-0.3	-0.3
Asthma (self-reported)	0.4	0.9	3.3	-1.4	-0.1	-1.8	0.1	-0.6	0.0	0.6
Osteoporosis (self-reported)	0.7	0.9	2.6	-1.1	-0.5	-1.1	0.5	-0.7	0.5	-1.6
Osteoarthritis (self-reported)	0.2	0.3	1.4	-1.2	-0.0	-0.3	0.1	-0.4	-0.4	0.4
Medication: Aspirin	0.7	0.9	3.4	0.6	0.4	-1.0	-0.6	0.8	-0.3	1.8
Medication: Gliclazide	0.5	0.6	2.3	1.2	0.2	1.5	-0.2	-0.3	0.3	0.0
Illnesses of father: None of the above (group 1)	0.1	0.2	0.8	0.9	0.3	-0.1	-0.3	0.3	-0.4	0.1
Smoking status: Current	0.7	1.1	3.9	2.0	-0.1	0.7	-0.0	-1.4	0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.2	1.2	-0.1	1.5	0.1	0.4	1.3	1.1
Whole body water mass	0.5	2.6	13.8	1.6	-0.6	0.5	0.5	3.7	1.1	0.0
Leg predicted mass (right)	0.5	2.5	13.4	1.5	-0.6	0.2	0.5	3.7	1.0	-0.3
Arm fat mass (left)	0.7	2.8	5.7	-0.8	-2.1	-1.6	2.0	1.4	2.4	0.7
Number of self-reported non-cancer illnesses	0.7	1.3	3.6	0.5	0.7	1.1	-0.7	1.2	-1.2	1.9
Average weekly champagne plus white wine intake	1.0	1.3	4.2	1.2	1.1	-0.9	-1.1	0.4	0.5	2.0
Miserableness	1.6	2.7	4.8	-0.8	1.9	0.7	-1.8	-1.9	-2.2	1.5
Guilty feelings	2.9	4.4	10.5	0.8	2.7	1.0	-2.7	0.4	-3.2	2.0
Wears glasses or contact lenses	1.6	1.8	3.5	-0.5	1.9	-1.1	-1.9	1.1	-1.1	1.2
Ever taken oral contraceptive pill	1.4	1.5	3.3	1.8	1.1	1.1	-1.1	1.6	-0.7	-0.9
Hearing aid user	1.1	1.3	2.3	1.5	1.4	1.1	-1.4	1.0	-0.4	0.3
Mother’s age at death	0.3	0.4	1.0	-0.8	0.3	-0.4	-0.1	-0.9	-1.0	-0.4
Financial situation satisfaction	0.9	1.1	3.1	-1.5	0.8	0.6	-0.8	-0.8	-1.8	0.3
Tinnitus: Yes, now most or all of the time	1.4	1.6	4.5	-0.6	2.1	-0.2	-2.0	-1.4	-0.8	0.2
Commuting to job workplace: Public transport	2.6	3.1	10.1	1.9	-0.2	1.2	0.1	3.2	1.2	-2.2
Eye problems/disorders: Glaucoma	1.2	1.5	6.4	-1.5	-0.8	-2.5	0.7	-0.4	-0.5	-0.1
Medication: Blood pressure	0.6	1.1	2.3	0.8	-1.2	-0.1	1.0	1.3	0.8	-1.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.0	-0.8	0.4	-0.7	-0.5	-1.4	0.4	-0.1
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.6	0.1	1.1	-0.9	-1.2	0.9	-2.1	1.2
High cholesterol (Self-reported)	0.6	1.0	2.2	0.8	1.5	0.1	-1.5	1.0	-0.8	0.9
Medication: Bendroflumethiazide	0.3	0.5	2.2	-0.3	0.3	-0.4	-0.3	-0.0	-0.8	1.5
Medication: Paracetamol	0.4	0.7	1.3	0.5	-0.8	1.1	0.9	0.6	1.1	0.1
Medication: Lisinopril	0.9	1.2	3.0	-1.4	-0.4	-0.3	0.4	-1.5	-1.1	1.7
Medication: Atorvastatin	0.2	0.2	1.1	0.1	0.2	0.1	-0.2	-1.1	0.3	0.1
Illnesses of father: High blood pressure	2.0	2.4	5.7	-0.7	-2.2	-0.3	2.4	-1.0	1.9	-1.2
Alcohol drinker status: Never	0.9	1.1	2.5	-0.0	1.4	1.6	-1.4	0.2	-0.8	0.7
Ever smoked	1.3	2.3	6.9	1.0	1.3	2.6	-1.3	0.6	-2.1	0.0
Basal metabolic rate	0.5	2.6	13.1	1.3	-0.9	0.2	0.8	3.6	1.4	0.0
Leg fat percentage (left)	1.1	3.9	6.4	-2.2	-2.2	-2.5	2.2	-0.5	2.5	0.6
Arm fat-free mass (left)	0.3	1.5	8.1	0.9	-0.5	-0.0	0.5	2.9	0.8	0.1
Number of operations (self-reported)	0.4	0.5	1.1	1.0	0.0	1.1	-0.2	1.0	-0.4	0.8
Average weekly beer plus cider intake	4.0	5.7	13.1	-2.4	-2.3	-3.6	2.3	-1.8	1.8	-2.1
Irritability	0.5	0.8	2.6	-0.6	0.5	-0.2	-0.5	-0.8	-1.3	-1.6
Risk taking	1.4	2.1	5.1	1.8	-0.5	1.7	0.4	1.8	-0.1	-2.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.2	0.5	0.6	1.5	-0.5	1.4	-0.2	0.1
Fractured/broken bones in last 5 years	0.3	0.4	0.8	-0.9	-0.9	0.2	0.9	-0.1	0.4	-0.5
Age started oral contraceptive pill	0.7	0.9	4.0	0.3	-0.6	0.9	0.5	2.0	0.6	0.6
Diastolic blood pressure, automated reading	1.0	3.1	15.7	-1.8	-1.1	-4.0	1.1	-0.4	0.1	0.3
Ever depressed for a whole week	2.4	3.0	6.5	1.4	2.5	0.2	-2.5	0.1	-2.4	0.6
Unable to work because of sickness or disability	0.4	0.5	1.8	-0.1	-0.7	0.5	0.7	-1.3	0.0	0.4
Commuting to job workplace: Cycle	0.9	1.1	4.0	0.9	0.9	0.1	-0.8	1.0	-0.6	-2.0
Myopia	0.3	0.4	1.1	0.1	0.0	-0.9	0.1	0.3	-0.8	1.0
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.1	-0.4	-1.3	0.3	1.3	-0.7	1.4	-1.8
Cholesterol lowering medication	0.2	0.4	1.1	0.6	-0.3	0.1	0.2	-0.1	0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	2.0	-0.7	-0.2	-0.3	0.1	-1.4	-0.3	-0.1
Pain experienced in last month	0.3	0.5	1.3	-0.2	-1.2	0.1	1.1	-0.3	0.6	-0.5
Supplements: Calcium	1.4	1.6	5.2	0.4	1.5	0.4	-1.5	-0.9	-2.3	-0.6
Basal cell carcinoma (self-reported)	1.2	1.5	3.1	1.8	0.4	1.4	-0.3	1.4	0.5	-1.7
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.9	-0.6	0.6	0.5	-0.5	-1.7	-0.4	1.0
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.1	1.0	1.8	1.1	-1.7	-0.2	-0.3	-0.3
Heart disease (siblings)	0.8	1.0	4.4	-0.9	0.0	-0.9	-0.0	-0.3	-2.1	0.8
Alcohol drinker status: Previous	0.5	0.6	1.8	-1.2	-0.3	-0.3	0.3	-1.3	0.0	0.7
Pack years of smoking	0.8	1.1	2.2	-0.4	-1.2	-1.0	1.0	-1.2	1.5	-0.8
Impedance of whole body	0.2	0.8	3.2	0.1	0.8	1.8	-0.6	-1.0	-0.2	0.7
Leg fat mass (left)	0.6	2.2	3.9	-1.1	-1.7	-2.0	1.6	0.8	1.9	0.5
Arm predicted mass (left)	0.3	1.7	8.9	1.0	-0.7	0.1	0.6	3.0	1.0	0.1