Hub : Genes

PPIP5K1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Pancreas 0.3040 0.1110 0.00060 0.013 NA 0.020 NA 0.044 0.08500 NA 0.046 NA 0.0060
2 TCGA Head and Neck Squamous Cell Carcinoma 0.0471 0.0286 0.00061 0.030 0.024 0.013 NA 0.018 0.00025 0.00086 0.011 NA 0.0033

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.1 0.2 0.3 -0.5
Bipolar Disorder or Schizophrenia 1.1 2.7 3.5 -1.9 -1.4
Depressed Affect (Nagel 2018) 1.5 3.1 5.9 -0.5 -2.4
Depression (Nagel 2018) 1.3 1.9 3.8 -0.2 -2.0
Intelligence (Savage-Jansen 2018) 1.5 4.7 9.3 3.0 0.3
Neuroticism (Nagel 2018) 3.1 7.3 14.6 0.1 -3.8
Schizophrenia (2018) 2.2 4.5 6.9 -2.6 -1.5
Schizophrenia vs Biploar Disorder 0.6 0.8 1.6 -1.2 -0.3
Worry (Nagel 2018) 4.7 9.8 19.6 -0.2 -4.4
Alzheimer’s Disease (in mother) 1.9 2.2 3.1 -1.8 -1.1
Alzheimer’s Disease (in father) 0.4 0.5 1.0 -0.1 1.0
Alzheimer’s Disease (including proxy) 1.5 2.1 4.1 -2.0 -0.4
Crohns Disease (2017) 0.3 0.7 1.3 1.1 -0.4
Irritable Bowel Disease (IBD) 0.5 1.1 2.2 0.1 -1.5
Ulcerative Colitis (UC) 1.1 2.0 3.4 -0.8 -1.8
Major Depression (MDD) 1.6 2.0 2.5 -1.6 -1.2
Reaction Time 1.7 3.3 4.4 1.5 2.1
Verbal and Numeric Reasoning (VNR) 1.3 3.2 5.8 2.4 -0.7
Breast Cancer 1.8 4.4 4.7 2.0 2.2
Ovarian Cancer 2.1 2.8 3.9 2.0 1.3
Prostate Cancer 0.8 1.1 2.2 -1.5 -0.2
Age at First Birth 6.8 9.9 19.8 4.4 0.1
Bipolar Disorder (2011) 0.6 0.5 0.9 0.9 -0.5
Body Mass Index (BMI) (2010) 3.9 5.4 7.2 -2.7 1.9
Coronary Artery Disease (CAD) 1.7 2.0 3.9 -0.2 -2.0
Crohns Disease (2012) 0.9 1.5 3.0 1.7 0.3
Mean Putamen Volume 0.5 0.5 1.0 1.0 -0.2
Fasting Glucose 0.9 1.1 1.4 -1.2 0.8
HbA1C 2.5 2.8 3.2 -1.5 -1.8
HDL Cholesterol 0.2 0.3 0.4 -0.4 0.6
LDL Cholesterol 0.3 0.5 0.6 -0.8 -0.5
Lupus 1.4 2.1 3.8 2.0 0.6
Neuroticism (2016) 2.0 2.9 5.9 -0.0 -2.4
Primary Biliary Cirrhosis 2.0 2.8 5.6 -0.2 2.4
Rheumatoid Arthritis 0.3 0.4 0.5 -0.5 -0.7
Schizophrenia (2014) 2.4 5.3 7.4 -2.7 -1.8
Triglycerides 3.1 5.0 6.4 1.9 -2.5
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.1 -0.3 0.2
Ulcerative Colitis 0.4 0.6 1.1 -0.3 -1.1
Blood Eosinophil Count 2.3 17.4 34.6 0.4 5.9
Blood Platelet Count 1.6 18.4 28.4 2.9 -5.3
Blood Red Count 0.6 5.7 10.8 -3.3 0.8
Blood White Count 0.5 3.7 4.7 -2.2 -1.7
Heel T-Score 0.4 3.0 5.9 2.4 -0.5
BMI 0.8 4.6 9.3 -3.0 0.1
Height 0.1 1.5 2.9 1.7 0.4
Waist Hip Ratio (WHR) 0.2 0.9 1.4 -0.7 -1.2
Systolic Blood Pressure 0.4 1.9 3.5 1.9 0.6
Smoking Status 0.5 1.2 2.2 -1.5 -0.4
Allergy or Eczema 0.1 0.1 0.3 -0.5 0.1
Cardiovascular Disease 0.2 0.5 0.6 0.7 -0.8
Hypothyroidism (self reported) 0.6 1.4 2.6 -0.3 -1.6
Respiratory disease 0.2 0.5 0.7 -0.9 -0.5
Type 2 Diabetes (T2D) (2018) 0.8 1.5 2.1 -0.9 1.4
Lung FEV1/FVC ratio 0.2 1.0 1.3 0.9 -1.1
Lung FVC 1.0 5.3 6.5 2.0 2.6
Neuroticism 2.6 6.4 12.7 -0.2 -3.6
Chronotype (morning person) 2.2 5.1 5.5 2.2 -2.3
Hair Pigment 0.2 4.5 9.0 -0.2 -3.0
Tanning 0.0 0.2 0.2 0.5 -0.5
Hand grip strength (left) 0.7 1.9 2.6 -1.6 1.1
Number of treatments/medications taken 1.0 1.7 3.4 1.9 0.3
Average weekly spirits intake 0.2 0.3 0.4 0.4 0.6
Sensitivity / hurt feelings 0.5 0.9 1.6 -0.5 -1.3
Frequency of depressed mood in last 2 weeks 1.3 1.8 3.3 -0.6 -1.8
Hearing difficulty/problems: Yes 0.4 0.6 0.8 -0.9 -0.6
Relative age of first facial hair 1.4 2.9 5.2 0.7 -2.3
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.4 1.2 -0.7
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.5 -0.5 -0.7
Ever had hysterectomy (womb removed) 0.6 0.7 0.7 -0.8 -0.8
Systolic blood pressure, automated reading 0.2 0.6 0.6 0.7 -0.8
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.3 -0.2 1.1
Angina 0.3 0.4 0.4 0.6 -0.7
Medication for hormone replacement therapy 0.0 0.0 0.0 -0.2 0.2
Vitamin and mineral supplements 6.6 9.0 17.9 -4.2 -0.1
Supplements: Zinc 5.9 6.4 10.9 3.3 -1.4
Medication: Co-codamol 0.2 0.2 0.3 0.3 0.5
Medication: Metformin 1.9 2.7 5.3 -0.3 2.3
Diabetes (father) 2.2 2.7 4.9 -2.2 0.7
Diabetes (mother) 0.2 0.3 0.6 -0.8 0.1
Severe depression (siblings) 0.1 0.1 0.1 -0.4 -0.4
Pack years adult smoking proportion 1.1 1.7 2.4 -1.6 -0.9
Impedance of leg (right) 0.5 2.3 2.3 1.5 -1.5
Leg fat-free mass (left) 0.2 1.2 1.2 -1.1 1.0
Trunk fat percentage 0.3 1.1 2.1 -1.4 0.3
Hand grip strength (right) 0.5 1.2 1.4 -1.2 1.0
Townsend deprivation index at recruitment 0.9 1.3 2.2 -1.5 -0.7
Current tobacco smoking 1.5 2.5 4.9 -2.2 0.1
Average weekly fortified wine intake 0.8 0.9 1.9 1.4 -0.0
Maternal smoking around birth 4.7 6.8 8.5 -2.9 -2.3
Fed-up feelings 1.7 3.1 5.0 -1.1 -2.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.5 0.6 -0.8 -0.5
Relative age voice broke 1.1 1.7 3.3 -0.1 -1.8
Taking other prescription medications 0.5 0.8 1.5 1.2 0.0
Age when periods started (menarche) 1.1 2.5 4.5 2.1 0.8
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.6 -0.5 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.3 0.5 -0.5
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.0 -0.0 0.2
Qualifications: CSEs or equivalent 0.4 0.6 1.1 -1.1 -0.1
Serious illness, injury or assault to yourself 0.4 0.5 0.5 -0.7 -0.6
High blood pressure 0.6 1.8 2.2 1.2 -1.5
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.7 -0.8 0.3
Multivitamins +/- minerals 5.6 7.1 14.0 3.7 -0.4
Stomach or abdominal pain in last month 0.4 0.5 0.9 -0.9 0.3
Supplements: Glucosamine 0.9 1.1 1.8 1.3 0.7
Diverticular disease/diverticulitis (self-reported) 4.2 5.0 6.3 -1.9 -2.5
Medication: Atenolol 0.6 0.8 0.9 0.9 0.8
Medication: Levothyroxine sodium 0.2 0.3 0.4 0.4 -0.6
Sitting height 0.4 2.6 4.6 -0.8 2.1
Chronic bronchitis/emphysema (father) 0.8 1.0 1.8 -1.3 -0.4
High blood pressure (mother) 0.3 0.4 0.8 0.1 0.9
Body mass index (BMI) 0.8 3.3 6.2 -2.5 0.7
Impedance of leg (left) 0.4 2.1 2.4 1.6 -1.4
Leg predicted mass (left) 0.3 1.4 1.4 -1.2 1.2
Trunk fat mass 0.3 1.5 2.8 -1.7 0.5
Waist circumference 0.5 1.8 3.6 -1.9 -0.2
Number of incorrect matches in round 1.3 2.1 3.0 -1.1 1.7
Past tobacco smoking 0.2 0.4 0.6 0.4 0.8
Alcohol usually taken with meals 1.3 2.1 3.8 0.7 1.9
Nervous feelings 2.9 5.4 10.8 -0.2 -3.3
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.1 -0.7 -1.0
Hearing difficulty/problems with background noise 1.5 2.4 4.2 -2.1 0.7
Hair/balding pattern: Pattern 2 0.3 0.4 0.4 -0.5 0.7
Had menopause 0.3 0.4 0.6 -0.3 -0.8
Had other major operations 0.4 0.5 0.9 1.0 -0.1
Forced vital capacity (FVC) 0.6 2.2 2.8 1.7 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.4 0.3 0.6
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.7 -0.9 -0.3
Qualifications: None of the above 2.6 5.7 11.2 -3.3 -0.3
Financial difficulties in last 2 years 1.7 2.2 3.1 -1.8 1.2
Mouth/teeth dental problems 1.2 1.9 2.5 1.6 1.1
Heart attack 0.1 0.1 0.1 -0.3 0.3
Allergy 0.2 0.5 1.0 1.0 0.3
Pain all over the body in last month 0.3 0.3 0.6 0.3 -0.8
Diabetes (self-reported) 0.7 1.1 2.0 -0.3 1.4
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.4 0.7 0.7
Medication: Ramipril 0.7 1.0 1.1 0.9 -1.0
Medication: Simvastatin 0.2 0.3 0.5 0.4 -0.7
Fluid intelligence score 0.8 1.7 3.1 0.5 1.8
Illnesses of siblings 1.9 2.7 5.1 2.3 0.6
Neuroticism score 3.4 7.2 13.7 -0.8 -3.7
Weight 0.4 1.9 3.0 -1.7 0.9
Impedance of arm (right) 0.8 3.9 6.9 2.6 -1.0
Arm fat percentage (right) 0.4 1.4 2.4 -1.6 0.6
Trunk fat-free mass 0.2 1.4 1.8 -1.0 1.4
Hip circumference 0.5 2.1 3.1 -1.8 1.0
Time employed in main current job 0.9 1.0 1.9 0.3 -1.4
Alcohol intake versus 10 years previously 1.7 2.5 2.8 -1.7 -1.5
Father’s age at death 2.0 2.6 5.3 2.3 -0.1
Worrier / anxious feelings 1.6 3.1 5.7 -0.7 -2.4
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 4.2 -2.1 -0.8
Falls in the last year 0.5 0.7 1.0 -0.6 -1.0
Hair/balding pattern: Pattern 3 1.3 2.0 2.0 -1.4 -1.4
Number of live births 0.1 0.2 0.4 -0.1 0.6
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 4.6 2.1 1.4
Pulse rate 0.3 0.5 0.8 0.9 0.4
Happiness 1.4 1.7 2.5 -1.0 -1.6
Noisy workplace 0.6 0.7 0.9 -0.9 -0.7
Qualifications: A levels/AS levels or equivalent 0.8 1.8 2.1 1.5 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.3 -0.1 0.5
Mouth/teeth dental problems: Dentures 0.4 0.7 1.3 -0.3 -1.2
Asthma 0.2 0.3 0.4 -0.5 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.4 -0.5 0.6
Medication: Cholesterol lowering 0.2 0.3 0.3 0.6 0.5
Depression (self-reported) 3.1 3.7 7.0 0.7 -2.6
Medication: Lansoprazole 0.0 0.0 0.0 -0.1 -0.1
Prospective memory result 1.2 1.5 3.0 1.7 -0.0
Lung cancer (father) 3.8 4.5 6.4 -2.5 -1.6
Illnesses of mother 0.1 0.1 0.1 0.1 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.2 4.7 2.2 1.9
Pulse wave Arterial Stiffness index 1.2 1.3 2.7 1.6 0.1
Impedance of arm (left) 0.6 3.0 5.7 2.4 -0.5
Arm fat mass (right) 0.5 2.0 3.0 -1.7 0.9
Trunk predicted mass 0.3 1.7 2.2 -1.1 1.5
Standing height 0.1 1.3 2.0 1.4 0.8
Length of working week for main job 0.2 0.2 0.5 0.7 0.2
Exposure to tobacco smoke at home 1.6 1.8 2.3 1.5 -1.1
Breastfed as a baby 3.1 3.8 7.2 2.7 0.6
Tense / ‘highly strung’ 7.1 11.8 22.8 -0.9 -4.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.9 -0.2 -0.9
Hair/balding pattern: Pattern 4 0.2 0.5 1.0 -0.1 1.0
Birth weight of first child 0.2 0.4 0.7 -0.8 -0.2
Peak expiratory flow (PEF) 3.0 7.0 14.0 0.1 3.7
Pulse wave reflection index 0.5 0.6 0.7 0.7 -0.8
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 -0.3 0.6
Loud music exposure frequency 3.2 3.5 5.3 -2.3 -1.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.0 1.4 0.5
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.3 -1.5 -0.5
Blood clot in the leg (DVT) 0.7 1.0 1.1 -1.0 -0.9
Medication: Paracetamol 0.4 0.7 1.0 0.6 1.0
Headache pain in last month 1.0 1.8 3.5 0.2 -1.9
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.0 -1.4 -0.8
Glaucoma (self-reported) 0.7 0.8 1.5 -0.4 1.2
Gout (self-reported) 0.4 0.5 0.8 0.9 -0.5
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.0 -1.0 -0.8
Medication: Amlodipine 1.1 1.5 2.5 -0.7 -1.6
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.5 0.7 -0.5
Birth weight 0.1 0.3 0.3 0.5 0.5
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 -0.0 0.6
High blood pressure (siblings) 0.3 0.4 0.6 -0.7 -0.5
Forced vital capacity (FVC), Best measure 0.8 3.0 3.4 1.9 1.6
Body fat percentage 0.3 1.1 2.2 -1.5 0.2
Leg fat percentage (right) 0.4 1.3 2.3 -1.5 -0.5
Arm fat-free mass (right) 0.4 2.1 2.2 -1.4 1.5
Exposure to tobacco smoke outside home 2.6 3.4 4.5 -2.1 -1.6
Comparative body size at age 10 1.5 4.3 8.5 -0.3 2.9
Number of full brothers 1.9 2.3 4.2 -2.1 -0.7
Worry too long after embarrassment 1.1 1.9 3.7 0.1 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.5 1.2 -0.4
Wheeze or whistling in the chest in last year 1.1 2.0 2.2 -1.3 -1.5
Number of children fathered 2.8 3.2 6.1 -2.5 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 3.9 0.5 2.0
Age at first live birth 1.8 3.2 5.8 2.4 -0.8
Pulse wave peak to peak time 0.9 1.0 2.1 -1.4 -0.0
Health satisfaction 0.8 1.1 1.5 -0.8 -1.2
Shortness of breath walking on level ground 1.6 1.9 2.8 -1.7 1.0
Qualifications: College or University degree 0.9 2.9 3.9 2.0 1.4
Eye problems/disorders: None of the above 1.6 1.8 3.4 0.5 -1.8
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.6 -0.8 -0.2
Emphysema/chronic bronchitis 2.0 2.2 4.4 -2.1 0.2
Medication for pain relief, constipation, heartburn 1.5 2.6 5.1 -0.0 -2.3
Neck or shoulder pain in last month 1.7 2.4 2.5 -1.5 -1.6
Medication: Blood pressure 0.1 0.2 0.3 -0.1 -0.6
Angina (self-reported) 0.1 0.2 0.2 0.5 -0.4
Migraine (self-reported) 2.3 2.8 3.0 1.6 -1.7
Medication: Ibuprofen 0.0 0.0 0.0 -0.2 0.1
Medication: Allopurinol 0.0 0.0 0.0 -0.1 0.0
Medication: Omeprazole 3.0 3.6 4.3 -2.1 1.7
Medication: Seretide 50 evohaler 2.9 3.3 6.5 0.5 2.5
Mean time to correctly identify matches 2.0 3.7 5.6 2.4 1.4
Heart disease (mother) 0.8 1.0 1.2 -0.8 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.0 3.0 -1.7 1.0
Whole body fat mass 0.3 1.1 2.1 -1.4 0.3
Leg fat mass (right) 0.4 1.6 3.2 -1.8 -0.1
Arm predicted mass (right) 0.4 1.8 2.1 -1.5 1.2
Pulse rate, automated reading 0.5 1.7 3.0 1.7 0.7
Alcohol intake frequency. 1.6 3.6 3.7 -1.9 -1.9
Comparative height size at age 10 0.1 0.4 0.8 0.9 0.1
Number of full sisters 1.9 2.3 4.2 0.7 2.1
Suffer from ‘nerves’ 6.7 10.4 18.1 -1.7 -4.3
Overall health rating 2.0 4.3 6.9 -2.6 -1.3
Chest pain or discomfort 0.9 1.3 1.5 -1.2 -1.0
Had major operations 0.9 1.0 1.9 -1.4 0.3
Age at last live birth 1.8 2.6 5.0 2.2 -0.5
Family relationship satisfaction 2.1 2.5 3.1 -1.8 -1.4
Leg pain on walking 0.1 0.1 0.2 0.0 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.7 0.4 -0.8
Commuting to job workplace: Car/motor vehicle 2.9 3.3 5.9 -0.9 -2.4
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.4 -0.2
Medication: Aspirin 0.8 1.1 1.7 0.7 1.3
Supplements: Vitamin C 0.6 0.8 1.0 1.0 -0.8
Knee pain experienced in last month 0.1 0.2 0.2 -0.5 -0.3
Hypertension (Self-reported) 0.6 1.7 2.0 1.1 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.7 3.1 -0.5 1.8
Illnesses of father: Heart disease 0.3 0.4 0.7 -0.8 -0.4
Illnesses of siblings: Diabetes 4.8 5.9 9.8 -3.1 1.4
Smoking status: Previous 0.1 0.1 0.1 -0.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 1.3 1.1 0.8
Whole body fat-free mass 0.3 1.7 1.9 -1.2 1.4
Leg fat-free mass (right) 0.2 1.2 1.5 -1.0 1.2
Arm fat percentage (left) 0.5 1.8 2.9 -1.7 0.9
Average weekly red wine intake 1.7 2.5 4.5 0.7 2.1
Handedness (chirality/laterality): Left-handed 2.0 2.4 2.8 1.4 -1.7
Mood swings 0.7 1.3 2.7 -0.0 -1.6
Loneliness, isolation 6.0 8.3 16.5 0.3 -4.1
Long-standing illness, disability or infirmity 0.1 0.2 0.4 -0.3 -0.6
Ever had bowel cancer screening 0.3 0.4 0.7 0.8 -0.3
Diabetes diagnosed by doctor 1.4 2.3 4.6 -0.1 2.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.4 -0.3 0.7
Friendships satisfaction 1.4 1.7 2.8 -0.8 -1.7
Qualifications: nursing, teaching 0.4 0.6 0.6 0.7 0.8
Commuting to job workplace: Walk 0.5 0.5 0.7 0.6 0.8
Eye problems/disorders: Cataract 0.5 0.6 1.2 -0.2 1.1
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.5 -1.2 -0.7
Medication for cholesterol 0.5 0.8 1.6 0.1 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.4 0.6 -0.4
Back pain experienced in last month 1.3 1.9 3.8 -0.1 -2.0
Mineral and other dietary supplements 3.1 4.2 7.7 -2.8 0.8
Breast cancer (self-reported) 0.1 0.1 0.2 0.2 -0.5
Asthma (self-reported) 0.2 0.4 0.6 -0.8 -0.5
Osteoporosis (self-reported) 0.8 1.0 2.1 -1.4 -0.1
Osteoarthritis (self-reported) 1.2 1.5 3.1 -0.1 1.8
Medication: Aspirin 1.1 1.5 2.4 0.7 1.6
Medication: Gliclazide 3.5 3.9 7.0 -0.9 2.6
Illnesses of father: None of the above (group 1) 1.2 1.4 2.5 1.6 -0.6
Smoking status: Current 0.6 0.9 1.8 -1.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 2.1 1.4 0.9
Whole body water mass 0.3 1.7 2.1 -1.2 1.4
Leg predicted mass (right) 0.2 1.2 1.4 -1.0 1.2
Arm fat mass (left) 0.7 2.8 4.1 -2.0 1.2
Number of self-reported non-cancer illnesses 0.6 1.0 1.3 0.8 -1.1
Average weekly champagne plus white wine intake 0.9 1.2 2.4 -0.3 1.5
Miserableness 0.4 0.7 0.8 -0.9 -0.8
Guilty feelings 0.6 1.0 1.9 -0.0 -1.4
Wears glasses or contact lenses 0.8 0.9 1.7 0.3 1.3
Ever taken oral contraceptive pill 1.0 1.2 1.6 -0.8 1.3
Hearing aid user 0.8 0.9 1.8 -1.4 -0.2
Mother’s age at death 0.3 0.4 0.5 0.5 0.7
Financial situation satisfaction 1.1 1.4 1.9 -1.0 -1.4
Tinnitus: Yes, now most or all of the time 2.3 2.7 5.2 -2.3 0.5
Commuting to job workplace: Public transport 0.7 0.8 1.4 0.6 1.2
Eye problems/disorders: Glaucoma 0.8 1.0 1.5 -0.7 1.2
Medication: Blood pressure 0.1 0.2 0.4 0.7 -0.2
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.1 -0.8 1.1
Supplements: Fish oil (including cod liver oil) 2.0 2.6 5.2 2.3 -0.1
High cholesterol (Self-reported) 0.2 0.4 0.9 -0.1 -0.9
Medication: Bendroflumethiazide 0.4 0.6 0.7 0.7 0.8
Medication: Paracetamol 0.2 0.3 0.6 0.2 0.8
Medication: Lisinopril 3.2 4.2 7.2 1.1 2.7
Medication: Atorvastatin 0.3 0.4 0.7 0.2 -0.8
Illnesses of father: High blood pressure 0.5 0.6 0.9 -0.9 0.6
Alcohol drinker status: Never 2.3 2.8 5.0 -2.2 0.7
Ever smoked 0.6 1.0 1.9 -0.5 -1.4
Basal metabolic rate 0.3 1.7 1.7 -1.3 1.3
Leg fat percentage (left) 0.4 1.5 3.0 -1.7 -0.2
Arm fat-free mass (left) 0.4 2.2 2.9 -1.3 1.7
Number of operations (self-reported) 0.7 1.1 1.5 -1.2 0.8
Average weekly beer plus cider intake 0.1 0.2 0.2 0.4 0.4
Irritability 2.0 3.4 6.7 -0.1 -2.6
Risk taking 0.0 0.0 0.0 0.2 0.2
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.5 0.6 0.7
Fractured/broken bones in last 5 years 0.3 0.4 0.5 -0.6 -0.7
Age started oral contraceptive pill 0.7 0.9 1.6 0.5 -1.3
Diastolic blood pressure, automated reading 1.0 3.0 5.2 2.3 0.8
Ever depressed for a whole week 0.2 0.3 0.4 -0.7 -0.3
Unable to work because of sickness or disability 1.1 1.4 1.5 -1.2 -1.2
Commuting to job workplace: Cycle 0.3 0.4 0.7 0.8 -0.4
Myopia 0.4 0.5 1.1 1.0 0.2
Vascular/heart problems diagnosed by doctor 0.6 1.5 1.8 -1.3 1.1
Cholesterol lowering medication 1.1 1.6 3.1 -0.1 -1.8
Medication: Omeprazole (e.g. Zanprol) 2.2 2.6 3.3 -1.4 1.8
Pain experienced in last month 0.9 1.5 3.0 -0.2 1.7
Supplements: Calcium 2.2 2.4 4.6 0.3 -2.1
Basal cell carcinoma (self-reported) 0.4 0.5 1.0 1.0 0.0
Heart attack/myocardial infarction (self-reported) 0.0 0.1 0.1 -0.3 0.1
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 1.4 -1.2 -0.7
Heart disease (siblings) 1.0 1.3 2.5 -1.6 0.3
Alcohol drinker status: Previous 2.8 3.2 6.4 0.1 -2.5
Pack years of smoking 1.3 1.9 2.9 -1.7 -1.0
Impedance of whole body 0.6 3.2 4.9 2.2 -1.2
Leg fat mass (left) 0.5 1.8 3.5 -1.9 0.3
Arm predicted mass (left) 0.4 2.0 2.4 -1.2 1.6